SARMsPharm Therapy Shows Large Muscle Gains How you can big, strong muscles is long and requires hard work in a gym. But researchers may have found a shortcut where the muscles grow by themselves. Scientists have actually succeeded, in the form of gene therapy, to boost the lean body mass and the strength of macaque monkeys. The experiment was simple enough, the researchers just injected the gene follistatin (FS344) straight into the monkeys right thigh muscles. It's been shown that follistatin can block myostatin, a molecule that down-regulates musclegrowth, but strengthens tendons. Eight weeks after the injection the circumference of the monkeys right thigh muscles, had normally gone up 15 percent weighed against the left thigh. A study done on two of the monkeys revealed that musclestrength in the proper leg was increased by respectively 12 and 36 per cent set alongside the untreated leg! The Follistatin is injected through a viral vector, that's a Adeno Associated Virus used as a transport for the drug that's injected. It is a common method called Gene Therapy, and has been utilized SARMs for sale in humans with other drugs. The research on the monkeys showed no negative side effects. This therapy will be developed for use in patients with severe muscle dystrophy and other muscle wasting disorders. Clinical trials on humans are due to begin in 2011 and Nationwide Childrens Hospital in Ohio has recently gained funding for the study. There are several studies and clinical trials either underway or planned for treatment of muscle wasting disorders, among some of the more interesting substances are Follistatin being an antagonist to Myostatin, Ostarine which really is a SARM(Selective Androgen Receptor Modulator) and is currently in Human clinical trials by GTx Inc. and also another SARM beneath the codename BMS-564,929 which will be being developed by Bristol-Myers Squibb. The potential for these substances to be abused by athletes has prompted the World Anti-Doping Agency to really have a ban on SARMs since 2008. Sofar only the substance referred to as "SARMs S4" (Andarine) has caused it to be to industry, and has been used by a small quantity of pro and amateur bodybuilders, it's anabolic effects are said to be moderate and it's been reported to have some temporary side effects, among which decreased night vision may be the more prominent. The future of drugs developed for muscle wasting diseases are sure to be of interest for athletes and others wanting to achieve the extra advantage. Another 5-10 years might find a plethora of substances come out and some might be good replacements for Anabolic steroids. These drugs will soon be available through the black market for pro and amateur athletes alike, with
unprecedented anabolic effects and near no negative side effects.