Multicomponent Reactions, Pyrroles and Imidazoles
â€˘ By Dr Anthony Melvin Crasto, Ph.D
This is a vast topic and a short overview is given and in no way complete justice can be done for this
Pyrrole is one of the most important simple heterocycles, which is found in a broad range of natural products and drug molecules, and is also of growing relevance in materials science. It was first isolated in 1857 from the products of bone pyrolysis, and identified as biologically relevant when it was recognized as a structural fragment of heme and chlorophyll. The current importance of pyrrole can be summarized in the points that are detailed below.
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