Citalopram: Drug absorption and Oral Bioavailability

9 Module 4 - Case Study Questions 1 The dose and frequency of administration you would use?

One of the factors that affect the dosage of Glyceryl trinitrate is the type of infusion made use of. Dose recommendation symbolized as glyceryl trinitrate mcg/min can only be given as a starting rate of infusion. Some of the major factors to consider before administering the drug to Leonard include assessing him for presence of circulatory disorders such as acute circulatory failure, hypotension and cardiogenic shock among others. Assessing the medical history of the patient will help determine whether Leonard has myocardial infarction, a condition under which glyceryl trinitrate should only be made use of strictly by the treating doctors. Consumption of other drugs should also be considered in determining the dosage and frequency of administering glyceryl trinitrate. Leonard is concerned which implies that the current dosage needs to be either down-regulated or increased in accordance with his therapeutic response. The frequency of administration also needs to be regulated under the guidance of current dosage of Glycerine trinitrate to minimize possible cases of overdose or underdose.

The patient’s vital signs and history you consider important?

Presence of medical history of cardiovascular disorders is important in the determination of dosage and frequency of administration of Glycerine trinitrate. The vital signs of the patient will help determine whether current medications are generating any positive results or not. Mr. Leonard is taking other drugs most of which have been shown to develop adverse side effects.

Monitoring of vital signs will therefore assist in determining the dosage of Glycerine trinitrate to start with.