BIOPTRON HYPERLIGHT THERAPY IN THE MANAGEMENT OF DERMATOLOGICAL DISORDERS
2022
Bioptron Medical Team
Properties of Bioptron light
Polarized: 95% of polarization, ensures optimal penetration of tissues to stimulate.
Polychromatic: Contains the visible light and a part of the infrared spectrum (350 to 3400nm). Does not include UV.
Incoherent: Dynamic penetration without the risk of damaging the tissue as coherent light.
Low energy: Consistent intensity of 2.4J /cm2 per minute safe and precise dose.
Hyperpolarized: Fullerene (C60) coated filter.
Mechanism
1079.
5. Iordanou P. Effect of visible and infrared polarized light on the healing process of full thickness skin wounds: an experimental study. Photomed Laser Surg. 2009 Apr;27(2):261 7.
8. Zhevago NA, Pro and anti inflammatory cytokine content in human peripheral blood after its transcutaneous (in vivo) and direct (in vitro) irradiation with polychromatic visible and infrared light. Photomed Laser Surg. 2006;24(2):129 139.
9. Zhevago, N.A., (2004). The regulatory effect of polychromatic (visible and infrared) light on human humoral immunity. Photochem Photobiol Sci. 3, 102 108.
10. Chumak AG,. Role of nitric oxide in modulation of afferent impulses in cutaneous branches of somatic nerves by polarized light. Bull Exp Biol Med. 2000 Aug;130(8):734 6.
11. Bolton P, (1992) The effect of polarised light on the release of growth factors from the U 937 macrophage like cell line. Laser Ther 2: 33 42.
of action
section of skin Polarized light penetration Cellular metabolism↑ Changes in the lipid bilayer, membrane surface charges, lipid-protein interaction1 Mitochondria stimulation, augmented cell energy and nucleic acid production2 Microcirculation↑ VEGF production↑3, neoangiogenesis↑5 Production of specific cells and proteins↑ Fibroblast stimulation, expression of type1 procollagen mRNA↑4 Kerotinocyte proliferation↑6 Growth factors↑11, collagen synthesis↑6 Regulation of inflammation↑ Th lymphocyte proliferation↑7 IgM and IgA↑9 Anti-inflammatory cytokine↑ Pro-inflammatory cytokine↓8 Nociceptive signals↓ Pain receptor activation↓ NO synthesis↑10 1. Kertesz I, Fenyö M, Mester E, Bathory G. Hypothetical physical model for laser biostimulation Opt Laser Technol.
32. 2. Tunèr J, Hode L. Laser therapy: clinical practice and scientific background. In Chapt 1 Some basic laser physics Prima Books AB, 2002; 1 44. 3 Akilbekova D, Boddupalli A, Bratlie KM. The effect of polarized light on the organization of collagen secreted by fibroblasts. Lasers Med Sci.
547. 4. Tada K.,
K., and Tomita, K. Effect of polarized light emitting diode irradiation on wound healing.
Cross
1982;14(1):31
2018;33(3):539
Ikeda
J. Trauma. 2009;67(5):1073
Hyperlight Therapy in Pain Bioptron Hyperlight Therapy is clinically tested and medically certified in the treatment of pain. Atopic dermatitis Psoriasis Herpes simplex Herpes zoster Superficial bacterial infections Acne Mucosal lesions EN ISO 13485:2016 by TÜV 93/42/EEC-Annex II by TÜV
Bioptron
Atopic dermatitis
Final assessment Treatment of Atopic Dermatitis Tabia, A., Mohamed,
& Selim, M. N. (2022). Ultrasonographic Response to Polarized Light Therapy in the Treatment of Atopic Dermatitis. Egyptian Journal of Physical Therapy, 9(1), 21-28. Inclusion Criteria • Age: 20-30 • Itching, inflammation, and skin thickness in the arm, wrist, hand or leg, chronic • Diagnosed by a dermatologist Outcomes • Skin thickness: Ultrasonography • SCORAD score Severity: affected body area Intensity: erythema, oedema/ papulation, excoriations, lichenification, oozing/crusts and dryness Subjectiveness: pruritus and sleeplessness Aim • To examine the effectiveness of polarized light therapy on SCORAD index and size of lesion areas with special infancies on the ultrasonographic skin thickness. Exclusion Criteria • Patients with skin cancer, history of diabetes, vascular or sensory disorders, and patients with an active infection of treated area. Day 0 Week 4 Initial assessment (n=20) Group A: Bioptron (n=20) Group B: Steroid creams 10cm distance, 10 minutes, 3 times per week Study • Active controlled, randomized, single blind, superiority, parallel clinical study Topical hydrocortisone 2.5%, once or twice a day
M. H.,
Treatment of Atopic Dermatitis
Ultrasonographic Response to Polarized Light Therapy in the Treatment of Atopic Dermatitis. Egyptian Journal of Physical Therapy, 9(1), 21-28. 16 16 8,7 9 0 2 4 6 8 10 12 14 16 18 20 Skin Thickness Before Bioptron group After Before Steroid group After Changes in Skin Thickness 32,6 32,9 5,2 9,1 0 5 10 15 20 25 30 35 40 SCORAD Score Before Bioptron group After Before Steroid group After Changes in SCORAD * Bioptron is a simple and effective procedure for treating of atopic dermatitis with no noticeable side effects specially those associated with long-term use of topical corticosteroid.
Tabia, A., Mohamed, M. H., & Selim, M. N.
(2022).
of Non-atopic Dermatitis: A Case Report Leguina-Ruzzi, A., Raichura, K. R., Tonks, S. K., Kwabi, S., & Leitner, C. (2019). Treatment of non-atopic dermatitis with polarized UV-free polychromatic light: A case report. Clinics and practice, 9(3), 1161. Outcomes • Photo-documentation • Erythema (ImageJ) • Pruritus (5-D itch scale) • Dryness (0-16 EEMCO method) Case • 67 year old female • Moderate non-atopic dermatitis for the past 20 years Application • 10cm distance, 10 minutes, every day • 6 weeks of treatment, 1 week follow-up
Treatment
Treatment of Non-atopic Dermatitis: A Case Report
Improvement of the lesions in the popliteal fossa
Leguina-Ruzzi, A., Raichura, K. R., Tonks, S. K., Kwabi, S., & Leitner, C. (2019). Treatment of non-atopic dermatitis with polarized UV-free polychromatic light: A case report. Clinics and practice, 9(3), 1161.
Treatment of Non-atopic Dermatitis: A Case Report
Improvement of the lesions in the popliteal fossa
Leguina-Ruzzi,
A., Raichura, K. R., Tonks, S. K., Kwabi, S., & Leitner, C. (2019). Treatment of non-atopic dermatitis with polarized UV-free polychromatic light: A case report. Clinics and practice, 9(3), 1161.
Treatment of Non-atopic Dermatitis: A Case Report
Improvement of the lesions in the hands
Leguina-Ruzzi,
A., Raichura, K. R., Tonks, S. K., Kwabi, S., & Leitner, C. (2019). Treatment of non-atopic dermatitis with polarized UV-free polychromatic light: A case report. Clinics and practice, 9(3), 1161.
Treatment of Non-atopic Dermatitis: A Case Report
Improvement of the overall dryness and itching
Biptron may offer an effective treatment option for chronic NAD that is well tolerated and free of side effects.
Leguina-Ruzzi, A., Raichura, K. R., Tonks, S. K., Kwabi, S., & Leitner, C. (2019). Treatment of non-atopic dermatitis with polarized UV-free polychromatic light: A case report. Clinics and practice, 9(3), 1161.Psoriasis
Waked, I. S.,
N.
assessment
Final
Treatment of Psoriasis
Inclusion Criteria • Patients with moderate-severe psoriasis • Skin types III and IV Outcomes • PASI Score • Ultrasonography (skin thickness) Aim • To evaluate the efficacy of linear polychromatic non-coherent light (Bioptron) in the treatment of plaque psoriasis. Exclusion Criteria • Other types of psoriasis • Photosensitivity Day 0 Week 4 Initial assessment (n=20) Experiment: Steroid cream + Bioptron (n=20) Control: Steroid cream 10cm distance, 6 minutes, 5 times per week Study • Randomized controlled study Topical steroid 0.1%, twice per week
& Abdelhamid,
D. (2015). The efficacy of linear polychromatic noncoherent light (bioptron light) in the treatment of plaque psoriasis. World Journal of Pharmaceutical Research SJIF, 4(5), 366-376.
Treatment of Psoriasis
Bioptron group, before Bioptron group, after Control group, before Control group, after
Bioptron has a potential benefit in the management psoriasis, the PASI & thickness of skin were decreased significantly after 4 weeks of combined treatment of BLT & topical steroid more than topical steroid only.
Waked, I. S., & Abdelhamid, N. D. (2015). The efficacy of linear polychromatic noncoherent light (bioptron light) in the treatment of plaque psoriasis. World Journal of Pharmaceutical Research SJIF, 4(5), 366-376. * p=0.001, ** p=0.000
14,53 8,33 15,53 14 0 5 10 15 20 25 PASI Score (072) Before After Before After 2,31 1,22 2,11 2,05 0 1 2 3 4 5 Thickness of skin (mm)
Before
9%↓ 43%↓ 3%↓ 47%↓ * **
After Before After
Changes in PASI Score Changes in skin thickness (USG)
assessment Treatment of Psoriasis Nosseir, A. A., Hamed, H. A., Ali, Z. A., & Elwasefy, S. A. (2020). Polarized Light Therapy versus Betamethasone Phonophoresis in Treatment of Psoriasis. Inclusion Criteria • People with chronic psoriasis in the arm and leg Outcomes • Ultrasonography (skin thickness) Aim • To evaluate the efficacy of linear polychromatic non-coherent light (Bioptron) in the treatment of plaque psoriasis. Exclusion Criteria • Other types of psoriasis • Photosensitivity Day 0 Week 4 Initial assessment (n=15) Group 1: Steroid cream + Bioptron (n=15) Group 3: Steroid cream 10cm distance, 10 minutes, 3 times per week Study • Randomized controlled study Topical steroid 0.1%, twice per week Group 2: Betamethasone phonophoresis (n=15)
Final
2,4 1,4 2,4 1,7 2,3 2,1 0 0,5 1 1,5 2 2,5 3 3,5 4 Thickness of skin (mm) Group 1, before Group 1, after Group 2, before Group 2, after Group 3, before Group 3, after
Psoriasis Nosseir, A. A., Hamed, H. A., Ali, Z. A., & Elwasefy, S. A. (2020). Polarized Light Therapy versus Betamethasone Phonophoresis in Treatment of Psoriasis. * p=0.03, ** p=0.001 8.6%↓ 41.6%↓ * Changes in skin thickness (USG) 29.1%↓ Before After Before After Before After ** Bioptron + Steroid cream Betamethasone phonophoresis Steroid cream Bioptron Hyperpolarized therapy is more effective in reducing thickness of skin of psoriatic areas in patients with psoriasis, compared to using Betamethasone phonophoresis or only steroid cream.
Treatment of
Reviews
Bioptron in reviews & expert opinions
Overall, BIOPTRON Light Therapy is an efficacious and low-cost form of dermato-cosmetic treatment.
It covers a wide range of possible applications (acne, seborrhea, skin irritations, allergies, scar management, etc.) and is easy to apply.
In summary, evidence suggests polarized light, as supplied by Bioptron devices, is clinically effective as a therapy in wound healing and in various dermatological diseases.
BLT is simple, clean, quick and non-invasive; furthermore, it is safe and well tolerated and has no known contraindications to date.
BIOPTRON Light Therapy fits well into the daily routine of therapeutic measures physicians and beauticians regularly implement in the best interest of their patients.
1. Hass HL (1998) Therapeutic effects of the BIOPTRON light in cosmetic medicine. Acne vulgaris. Krankenpfl J 1998 Oct; 36(10): pp 394-395Monstrey S (2000) Wound Care. Hospital Healthcare Europe 2000; pp 55-57
2. Begic Rahic, J., & Vranic, S. (2010). The Application of Bioptron Light Therapy in Dermatology and Wound Healing. European Dermatology, 5.
Bibliography
Herpes Simplex, Herpes Zoster
Marx A (2007) Amendment to the Clinical Evaluation of the BIOPTRON Light Therapy System, Version 01. BIOPTRON database 2007 (Case series, internal)
Aronis E, Braziotis A, Kafouros K, Pagratis N, Papakostas TH, Venetsanos P (1992) The Action of Visible Polarized Light on Skin Diseases. Poster Presentation 1992; 25: (Case series, internal)
Non-Atopic Dermatitis
Leguina-Ruzzi, A., Raichura, K. R., Tonks, S. K., Kwabi, S., & Leitner, C. (2019). Treatment of non-atopic dermatitis with polarized UV-free polychromatic light: A case report. Clinics and practice, 9(3), 1161. (case report)
Atopic dermatitis
Tabia, A., Mohamed, M. H., & Selim, M. N. (2022). Ultrasonographic Response to Polarized Light Therapy in the Treatment of Atopic Dermatitis. Egyptian Journal of Physical Therapy, 9(1), 21 28.
Psoriasis
Nosseir, A. A., Hamed, H. A., Ali, Z. A., & Elwasefy, S. A. (2020). Polarized Light Therapy versus Betamethasone Phonophoresis in Treatment of Psoriasis. Waked, I. S., & Abdelhamid, N. D. (2015). The efficacy of linear polychromatic noncoherent light (bioptron light) in the treatment of plaque psoriasis. World Journal of Pharmaceutical Research SJIF, 4(5), 366376.
Superficial bacterial infections
Taha, M. M., El-Nagar, M. M., Elrefaey, B. H., Elkholy, R. M., Ali, O. I., Alkhamees, N., & Felaya, E. S. E. E. S. (2022). Effect of Polarized Light Therapy (Bioptron) on Wound Healing and Microbiota in Diabetic Foot Ulcer A Randomized Controlled Trial. Photobiomodulation, Photomedicine, and Laser Surgery.
Rutteman B, Borremans K, Beckers J, Devleeschouwer E, Lampmann S, Corthouts I, Verlinde P. Aeromonas wound infection in a healthy boy, and wound healing with polarized light. JMM Case Rep. 2017 Oct 16;4(10):e005118. doi: 10.1099/jmmcr.0.005118. PMID: 29188066; PMCID: PMC5692235.
Acne Vulgaris
Internal Report_AMA Laboratories 1991 Investigation into the effects of a new treatment product on acne.
Internal Report, Begic-Rahic 2005, Appliance of Bioptron Light Therapy (BLT) in the Dermatology, Our Experience. Dermatovenereology Clinic. Clinical Centte of the university of Sarajevo, Bosnia and Herzegovina.
Reviews
Hass HL (1998) Therapeutic effects of the BIOPTRON light in cosmetic medicine. Acne vulgaris. Krankenpfl J 1998 Oct; 36(10): pp 394-395Monstrey S (2000) Wound Care. Hospital Healthcare Europe 2000; pp 55 57
Begic Rahic, J., & Vranic, S. (2010). The Application of Bioptron Light Therapy in Dermatology and Wound Healing. European Dermatology, 5.