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Table 5.10 tells about the relationship between the chewing habits and expression of p53 protein. Fifty (85%) respondents had some what chewing habits. Out of that, 49 (98%) positively expressed p53. Among the non chewers (total 9), only 3 (33%) expressed p53 protein. Table 5.10: Association between chewing habits and expression of p53 (N=52) Chewing habit

Expression of p53 Positive

Negative

n % within chewing habit

n

n

% within chewing habit

% within chewing habit

% of total

% of total

1 2 1.70 6 66.67 10.17 7 11.86 11.86

50 100.00 84.75 9 100.00 15.25 59 100.00 100.00

% of total Chewer

49 98 83.05 Non-chewer 3 33.33 5.08 Total 52 88.14 88.14 Pearson Chi-square tests: p = 0.04 6.

None

DISCUSSION The development of oral squamous cell carcinoma is generally accepted to be a multi-step process in which alternation in oncogene and tumor suppressor gene, play an important role (Abbas et al. 2003, p. 197). The aim of this study was to elucidate the outcome of tumor suppressor gene p53 mutation in the pathogenesis of OSCC by immunohistochemistry. Though extensive studies of p53 alteration in oral cancer have been done in western countries and some Asian countries, no study has yet been emerged from Bangladesh. This study would therefore be helpful in providing a Bangladeshi perspective.

Thesis on oral cancer and bangladesh  

The term oral cancer encompasses all malignancies that originate in the oral tissues. Squamous cell carcinoma of the oral cavity comprises 9...

Thesis on oral cancer and bangladesh  

The term oral cancer encompasses all malignancies that originate in the oral tissues. Squamous cell carcinoma of the oral cavity comprises 9...