New miracle drug to treat obesity

Obesity develops when these cells accumulate more lipids than they can handle, which causes them to malfunction. e overloaded fat cells release molecules that can cause a cascade of metabolic and in ammatory problems that increase a person’s risk of other seri- ous conditions and diseases such as diabetes, hypertension, cardiovascular disease, cancer and asthma.

To ease the stress of the e Universe is not the same today as it was yesterday. With each moment that goes by, a number of subtle but important changes occur, even if many of them are imperceptible on measurable, human timescales. e Universe is expanding, which means that the distances between the largest cosmic structures are increasing with time.

A second ago, the Universe was slightly smaller; a second lipid-ladened cells (and thus repair metabolic and in ammatory dysfunction), people with obesity often need to reduce their body weight by at least 5% to 10%. e traditional intervention to achieve this reduction is lifestyle changes (for instance, better diet and more exercise). However, these changes don’t work for everyone. Even if they do work, they rarely work quickly, and when it comes to metabolic and in ammatory dysfunction, the sooner it is repaired, the better.

A handful of drugs can reduce body weight by 5% to 10% but, similar to lifestyle changes, they don’t work for everyone. However, the new drug, tirzepatide, has left other drugs in its shadow: 91% of patients saw a reduction of at least 5%, with an average weight loss of 21% for the highest dose (compared to 3.1% for placebo).

Clinical trials revealed that the dual-targeting drug helped about 50% of the patients achieve long-term glucose control. However, those trials also revealed a big surprise: Tirzepatide provides weight loss that surpasses the leading weight loss drugs. In other words, it seemed that tirzepatide e ectively treats two of the most common diseases in the world: obesity and diabetes. It’s a powerful tool for weight loss because it reduces appetite and food intake; it’s a powerful tool in diabetes management because it stimulates insulin production.

Prior to the hot Big Bang, the Universe wasn’t lled with matter, antimatter, dark matter or radiation. It wasn’t lled with particles of any type. Instead, it was lled with a form of energy inherent to space itself: a form of energy that caused the Universe to expand both extremely rapidly and relentlessly, in an exponential fashion.

And then, abruptly, some 13.8 billion years ago, in ation ended. All of that energy, once inherent to space itself, got converted into particles, antiparticles, and radiation. With this transition, the in ationary era ended, and the hot Big Bang began. e rest if history’s they say...

Unsurprisingly, scientists don’t completely understand tirzepatide’s remarkable weight-losing results. One theory is that tirzepatide acts like a new synthetic hormone that triggers slightly di erent cellular processes than the natural hormones it was designed to mimic.

However, Eli Lilly, tirzepatide’s manufacturer, doesn’t need to understand why exactly the drug works in order to bring it to market. e company plans to apply for drug approval in April 2023.