World Sleep 2022 Scientific Program

World Sleep Society & the Italian Association of Sleep Medicine Present the Best of Sleep Medicine & Research

GATHER TO TRANSFORM GLOBAL SLEEP & CIRCADIAN HEALTH

WORLD SLEEP

WORLDSLEEPCONGRESS.COM

Scientific Program 1 | Scientific Program | WORLD SLEEP 2022

GATHER TO TRANSFORM GLOBAL SLEEP & CIRCADIAN HEALTH PROGRAM COMMITTEE Charles M. Morin, PhD (Canada) Université Laval

Dear Colleagues and Friends, WELCOME TO ROME FOR THE 16TH WORLD SLEEP CONGRESS. The scientific program for World Sleep 2022 is a robust schedule of clinical and basic research from the sleep community, featuring well over 300 hours of scientific content during courses, keynotes, symposia, and abstract presentations, along with numerous affiliated meetings, workshops, and industry symposia.

The World Sleep congress is unique in its ability to bring the world’s best in sleep medicine and research to a single location. Today’s world has introduced new challenges for such an endeavor, but we have remained committed to safety and have in place precautions and guidelines based on best practices to promote a safe and comfortable environment for the conference. We hope these in-person presentations, meetings, and discussions will stimulate your work, and we hope that you will have time for reunions with colleagues after such time apart.

Thank you for joining us in Rome for World Sleep 2022. Like for our previous congresses, we want you to leave World Sleep energized to continue your work, collaborate with colleagues, and advance sleep health worldwide. We will see you again soon for World Sleep 2023 in Rio de Janeiro during September 8 – 13, 2023.

Sincerely, World Sleep 2022 Program Committee

CHAIR

Oliviero Bruni, MD (Italy) Sapienza University Luigi Ferini-Strambi, MD, PhD (Italy) IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University Raffaele Ferri, MD (Italy) Oasi Research Institute IRCCS, Troina Birgit Högl, MD (Austria) Medical University of Innsbruck Yuichi Inoue, MD, PhD (Japan) Japan Somnology Center Clete Kushida, MD, PhD (United States) Stanford University Medical Center Allan O’Bryan (United States) World Sleep Society Thomas Penzel, PhD (Germany) Charité Universitätsmedizin Berlin Giuseppe Plazzi, MD, PhD (Italy) University of Bologna Dalva Poyares, MD, PhD (Brazil) Federal University of São Paulo Federica Provini, MD, PhD (Italy) University of Bologna Shelly Weiss, MD (Canada) University of Toronto Phyllis Zee, MD, PhD (United States) Northwestern University, Feinberg School of Medicine

3 | Scientific Program | WORLD SLEEP 2022

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TABLE OF CONTENTS 03 06 10 11 16 20 22 24 25 26 31 40 46 50 51 60 66 84 102 124 126 128 130

Welcome Program Overview Contact Information 2022 Committees General Information Transportation Hotels Visiting Rome Networking & Social Events Awards Keynote Speakers AIMS Annual Meeting Program Scientific Content FRIDAY SATURDAY SUNDAY MONDAY TUESDAY WEDNESDAY Sponsors & Exhibitors Industry Symposia Exhibit Hall Floor Plans

5 | Scientific Program | WORLD SLEEP 2022

2022 PROGRAM OVERVIEW CONGRESS PROGRAM DATES March 11-16, 2022

VENUE & LOCATION Roma Convention Center La Nuvola Viale Asia, 40, 00144 Roma RM, Italy romaconventiongroup.it La Nuvola, which translates to “the cloud,” is one of the most iconic buildings in the City of Rome. The EUR neighborhood was built in the 1930s to host the Universal Exhibition in Rome, and today it has become a business district that welcomes professionals and international guests from all over the world.

The area stands for architectural greatness—from buildings and gardens to streets and infrastructures. All roads lead to Rome.

INTERNATIONAL SCIENTIFIC CONTENT World Sleep 2022 will provide a unique opportunity to interact with sleep medicine professionals from around the world. Over 3500 attendees came to World Sleep 2019, representing 77 countries, and over 1500 international presenters brought 320 hours of scientific content to a worldwide audience. World Sleep 2022 is bringing that same international spirit and the best of sleep medicine and research to Rome.

SCIENTIFIC PROGRAM TOPICS • • • • • • • • • • • • • • • • • • • • •

Aging and Developmental Issues Basic Research Sleep and Cognition Chronobiology/Circadian Disorders Dental Dreaming Excessive Daytime Sleepiness/Hypersomnia Insomnia Movement Disorders Narcolepsy Neurological Sleep Disorders Affecting Sleep Parasomnia Pediatrics Pharmacology Psychiatric Disorders Affecting Sleep/Wake REM Behavior Disorders Restless Legs Syndrome (RLS) Sleep Breathing Disorders Sleep Health Technology/Technical Women

NETWORKING & SOCIAL EVENTS • • • • • • • •

Opening Ceremony Coffee Breaks Affiliate Meetings Poster Sessions Exhibit Hall World Sleep Day Networking Gala Dinner Closing Ceremony

6 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

TRANSFORMING LIVES. REDEFINING POSSIBILITIES.

For more than 15 years, Jazz Pharmaceuticals has been at the forefront of sleep medicine, redefining possibilities for people living with sleep disorders.

Learn more at jazzpharmaceuticals.com

January 2022 | INT-JPC-2200001 © 2022 Jazz Pharmaceuticals plc.

All rights reserved.

We have long understood that sleep disorders can impact every facet of someone’s life. For many people with these conditions, there are limited or no therapeutic options, which is why we have focused our resources on identifying and developing innovative sleep therapies to help redefine standards of care.

Our novel medicines often allow people to experience healthier, fuller lives, and to enjoy “small victories” over everyday tasks.

Join us in Room 11 at 10:45am on Tuesday

for symposium with leading faculty on orexin receptor antagonists and insomnia.

CME credit will be available for this session.

S37: OREXIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF INSOMNIA 10:45pm – 12:15pm | Room 11 | Chair: Clete Kushida (United States) 10:45am Introduction Clete Kushida (United States) 10:55am Current landscape of pharmacology treatments for insomnia Phyllis Zee (United States) 11:15am Interplay of pharmacologic approaches and cognitive behavioral therapy for insomnia (CBTI) in the management of insomnia Charles Morin (Canada)

11:35am Effects of orexin receptor antagonists on sleep and sleep architecture Claudio Liguori (Italy) 11:55am Role of orexin receptor antagonists in insomnia and other comorbidities Russell Rosenberg (United States)

Symposium supported by an unrestricted educational grant from Eisai Co., Ltd.

8 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

OPENING CEREMONY SUNDAY, MARCH 13 6:30PM–8:00PM

Sponsored by

OPENING REMARKS WELCOME TO ROME PROGRAM OVERVIEW AWARDS

ROMA CONVENTION CENTER

LA NUVOLA AUDITORIUM

RECEPTION

FOR MOST CURRENT UPDATES VISIT WORLDSLEEPCONGRESS.COM 9 | Scientific Program | WORLD SLEEP 2022

ADVANCING SLEEP HEALTH WORLDWIDE ABOUT THE ORGANIZERS World Sleep Society has collaborated with the Italian Association of Sleep Medicine to host World Sleep 2022.

The venue selected for the congress in Rome, Italy is Roma Convention Center La Nuvola.

HAVE QUESTIONS? EXHIBITOR & SPONSORSHIP QUESTIONS Allan O’Bryan, Executive Director obryan@worldsleepsociety.org

ABOUT ITALIAN ASSOCIATION OF SLEEP MEDICINE (AIMS) The Italian Association of Sleep Medicine (AIMS) is a multidisciplinary professional scientific society dedicated to promoting scientific research and clinical training in sleep medicine. In addition, AIMS promotes a more general awareness of sleep health and disorders among the Italian public. Founded in 1990, AIMS currently has over 400 members and organizes an annual meeting. Learn more at sonnomed.it

REGISTRATION QUESTIONS Administrative Assistant info@worldsleepsociety.org

GROUP BLOCK HOUSING REQUESTS Administrative Assistant info@worldsleepsociety.org

SCIENTIFIC PROGRAM QUESTIONS Meeting Manager granum@worldsleepsociety.org

PRESS & PUBLIC RELATIONS ABOUT WORLD SLEEP SOCIETY The mission of World Sleep Society is to advance sleep health worldwide. A professional membership organization for sleep physicians, researchers, and other sleep professionals, World Sleep Society manages a variety of programs for its members, the interdisciplinary field of sleep medicine, and the public. The biennial World Sleep congress is organized to build global connections among upcoming and experienced professionals in sleep medicine and research. Learn more at worldsleepsociety.org

Communications Coordinator ringstad@worldsleepsociety.org

EXHIBIT HALL QUESTIONS Administrative Assistant info@worldsleepsociety.org

MEMBERSHIP QUESTIONS Administrative Assistant info@worldsleepsociety.org

CONTACT INFORMATION World Sleep Society 3270 19th Street NW, Suite 109 Rochester, MN 55901 USA +001-507-316-0084 info@worldsleepsociety.org worldsleepsociety.org

10 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

2022 COMMITTEES SCIENTIFIC SELECTION FOR THE CONGRESS The Program Committee of each World Sleep congress is created following the World Sleep Society bylaws of committee formation, including six members of World Sleep Society and three members of the local host society. Topics are determined and proposal reviews organized by the Program Committee using established policies and procedures to mitigate bias and ensure scientific excellence. Read more at worldsleepsociety.org/scientific-selection-for-worldsleep-congress

EXECUTIVE COMMITTEE OF WORLD SLEEP SOCIETY

PROGRAM COMMITTEE Charles M. Morin, PhD (Canada) Université Laval

CHAIR

Oliviero Bruni, MD (Italy) Sapienza University Luigi Ferini-Strambi, MD, PhD (Italy) IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University Raffaele Ferri, MD (Italy) Oasi Research Institute IRCCS, Troina

Birgit Högl, President (Austria) Phyllis Zee, President-Elect (United States)

Birgit Högl, MD (Austria) Medical University of Innsbruck

Fang Han, Secretary (China) Maree Barnes, Treasurer (Australia)

Yuichi Inoue, MD, PhD (Japan) Japan Somnology Center

Charles Morin, Past-President (Canada)

GOVERNING COUNCIL OF WORLD SLEEP SOCIETY

Clete Kushida, MD, PhD (United States) Stanford University Medical Center

Lamia Afifi (Egypt)

Allan O’Bryan (United States) World Sleep Society

Isabelle Arnulf (France) Andrea Bacelar (Brazil)

Thomas Penzel, PhD (Germany) Charité Universitätsmedizin Berlin

Maree Barnes (Australia) Célyne Bastien (Canada) | Canadian Sleep Society Kelly Carden (United States) | American Academy of Sleep Medicine Peter Eastwood (Australia) Phil Gehrman (United States) | Sleep Research Society (SRS) Fang Han (China) Pierre-Herve Luppi (France) | European Sleep and Research Society Birgit Högl (Austria)

Giuseppe Plazzi, MD, PhD (Italy) University of Bologna Dalva Poyares, MD, PhD (Brazil) Federal University of São Paulo Federica Provini, MD, PhD (Italy) University of Bologna Shelly Weiss, MD (Canada) University of Toronto

Charles Morin (Canada) Shelly Weiss (Canada) Alan Young (Australia) | Australasian Sleep Association

Phyllis Zee, MD, PhD (United States) Northwestern University, Feinberg School of Medicine

Phyllis Zee (United States)

11 | Scientific Program | WORLD SLEEP 2022

2022 COMMITTEES SCIENTIFIC ADVISORY COMMITTEE The Scientific Advisory Committee is made of up experts that represent a broad range of sleep medicine and research specialties.

This committee plays a key role in the development of the scientific sessions by assisting the Program Committee to review and evaluate symposium proposals.

Fernanda Almeida (Canada)

Sharon Keenan (United States)

Dalva Poyares (Brazil)

Sonia Ancoli-Israel (United Sates)

Kristen Knutson (United States)

Federica Provini (Italy)

Monica Andersen (Brazil)

Andrew Krystal (United States)

Monica Puligheddu (United States)

Alon Avidan (United States)

Clete Kushida (United States)

Susan Redline (United States)

Maree Barnes (Australia)

Gilles Lavigne (Canada)

Rebecca Robillard (Canada)

Ruth Benca (United States)

Claudio Liguori (Italy)

Thomas Roth (United States)

Giulio Alessandri Bonetti (Italy)

Stanley Liu (United States)

Carlos Schenck (United States)

Oliviero Bruni (Italy)

Judette Louis (United States)

Alessandro Silvani (Italy)

Anna Castelnovo (Italy)

Atul Malhotra (United States)

Eileen Sloan (Canada)

Matteo Cesari (Austria)

Hrudananda Mallick (India)

Kai Spiegelhalder (Germany)

Yves Dauvilliers (France)

Rachel Manber (United States)

Ambra Stefani (Austria)

Lourdes DelRosso (United States)

Mauro Manconi (Switzerland)

Mehdi Tafti (Switzerland)

Helen Driver (Canada)

Bryce Mander (United States)

Daniel Taylor (United States)

Danny Eckert (Australia)

Marie Marklund (Sweden)

Robert Thomas (United States)

Colin Espie (United Kingdom)

Emmanual Mignot (United States)

Michael Thorpy (United States)

Luigi Ferini-Strambi (Italy)

Gustavo A. Moreira (Brazil)

Claudia Trenkwalder (Germany)

Raffaele Ferri (Italy)

Timothy Morgenthaler (United States)

Lynn Marie Trotti (United States)

Stuart Fogel (Canada)

Charles Morin (Canada)

Aleksandar Videnovic (United States)

Diego Garcia-Borreguero (Spain)

Philippe Mourrain (United States)

Shelly Weiss (Canada)

Roger Godbout (Canada)

Maria-Lucia Muntean (Germany)

John Winkelman (United States)

Cathy Goldstein (United States)

Brian Murray (Canada)

Antonio Zadra (Canada)

Marta Gonçalves (Portugal)

Tore Nielsen (Canada)

Laura Zamarian (Austria)

Dan Gottlieb (United States)

Lino Nobili (Italy)

Phyllis Zee (United States)

Michael Grandner (United States)

Laura Palagini (Italy)

Marco Zucconi (Italy)

Anna Heidbreder (Austria)

Ken Paller (United States)

Birgit Högl (Austria)

John Peever (Canada)

COURSE COMMITTEE

Rosemary Horne (Australia)

Thomas Penzel (Germany)

Sonia Ancoli-Israel (United States)

Yuichi Inoue (Japan)

Paola Pirelli (Italy)

Raffaele Ferri (Italy)

Ofer Jacobowitz (United States)

Giuseppe Plazzi (Italy)

Dalva Poyares (Brazil)

Ulf Kallweit (Germany)

Thomas Pollmächer (Germany)

12 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

2022 COMMITTEES INTERNATIONAL SCIENTIFIC COMMITTEE The International Scientific Committee is essential to the development of a scientifically and internationally balanced program, ensuring that the mission of advancing sleep health worldwide is being accomplished. The primary responsibility of the International Scientific Committee is to review and score oral and poster abstract submissions.

Lamia Afifi (Egypt) Aditya Ambati (United States) Sonia Ancoli-Israel (United States) Monica L. Andersen (Brazil) Clare Anderson (Australia) Erna Sif Arnardóttir (Iceland) Isabelle Arnulf (France) Jean-Jacques Askenasy (Israel) Najib Ayas (Canada) Maree Barnes (Australia) Célyne Bastien (Canada) Oliviero Bruni (Italy) Romola Bucks (Australia) Antje Büttner-Teleagă (Germany) Matteo Cesari (Austria) Yong Won Cho (South Korea) Valerie Cochen De Cock (France) Penny Corkum (Canada) Kimberly Cote (Canada) Naima Covassin (United States) Antonio Culebras (United States) Tom de Boer (Netherlands) Philip de Chazal (Australia) Joseph De Koninck (Canada) Sean Drummond (Australia) Jeanne F. Duffy (United States) Peter Eastwood (Australia) Danny Eckert (Austalia) Luigi Ferini-Strambi (Italy) Raffaele Ferri (Italy) John Fleetham (Canada) Arturo Garay (Argentina) Diego Garcia-Borreguero (Spain) Roger Godbout (Canada) Nadia Gosselin (Canada) Michael Grandner (United States)

Ludger Grote (Sweden) Reut Gruber (Canada) Wendy Hall (Canada) Fang Han (China) Ana C. Hanlon-Dearman (Canada) Jan Hedner (Sweden) Anna Heidbreder (Austria) Raphael Heinzer (Switzerland) Birgit Högl (Austria) Ying Huang (China) Yuichi Inoue (Japan) Osman Ipsiroglu (Canada) Poul Jørgen Jennum (Denmark) Amy Jordan (Australia) Ruby Joseph (India) Hakan Kaynak (Turkey) Sharon Keenan (United States) Elizabeth Keys (Canada) Jun Kohyama (Japan) Clete Kushia (United States) Gilles Lavigne (Canada) Claudio Liguori (Italy) Cheng-Hui Lin (Taiwan) Hrudananda Mallick (India) Marie Marklund (Sweden) Charles Morin (Canada) Soňa Nevšímalová (Czech Republic) Wolfgang Oertel (Germany) Judith Owens (United States) Murat Özgören (Turkey) Allan Pack (United States) Christopher Pantin (Australia) Vijaya Krishnan Paramasivan (India) Liborio Parrino (Italy) John Peever (Canada) Thomas Penzel (Germany) 13 | Scientific Program | WORLD SLEEP 2022

Giuseppe Plazzi (Italy) Dalva Poyares (Brazil) Federica Provini (Italy) F. Javier Puertas (Spain) Winfried Randerath (Germany) Graham J. Reid (Canada) Gabrielle Rigney (Australia) Renata L. Riha (United Kingdom) Leon Rosenthal (United States) Josée Savard (Canada) Carlos H. Schenck (United States) Priyattam Shiromani (United States) Garima Shukla (Canada) Rosalia Silvestri (Italy) Robert Skomro (Canada) Virend Somers (United States) Karel Šonka (Czech Republic) Kai Spiegelhalder (Germany) Ambra Stefani (Austria) Robyn Stremler (Canada) Patrick J Strollo, (United States) Eva Svanborg (Sweden) Mehdi Tafti (Switzerland) Robert Thomas (United States) Eus van Someren (Netherlands) Johan Verbraecken (Belgium) Malcolm von Schantz (United Kingdom) Youmeng Wang (China) Terri Weaver (United States) Shelly Weiss (Canada) Yun-Kwok Wing (Hong Kong) Juliane Winkelmann (Germany) Merrill S. Wise (United States) Phyllis Zee (United States) Marco Zucconi (Italy)

GUATEMALA

THAILAND

INDIA

ABOUT

GLOBAL EVENT

World Sleep Day is an annual event intended to be a celebration of sleep and a call to action on important issues related to sleep. Hosted by World Sleep Society, it is an opportunity for sleep experts to inform the public about the importance of sleep in all aspects of health.

Delegates in countries around the world participate in World Sleep Day each year by holding in-person, online, and media events that promote healthy sleep.

worldsleepday.org

twitter.com/_WorldSleep

ROMANIA

CHINA

SAVE THE DATE The next World Sleep Day is Friday, March 17, 2023. Sign up for updates at worldsleepday.org to follow the latest developments regarding the annual theme and activities.

facebook.com/wasmf

worldsleepday.org

Join Us Monday, March 14 for the World Sleep Day Meeting 1:00pm - 2:00pm | Room 31

14 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

Please join us for a live medical symposium sponsored

by Takeda Neuroscience Medical Affairs

Navigating Narcolepsy: The Science of Orexin and Diagnostic Challenges 12:30-2:00 p.m., Monday, 14 March, Room 15 Featuring Dr. Kiran Maski*, Prof. Emmanuel Mignot*, Prof. Giuseppe Plazzi* *Presenters are paid consultants for Takeda.

Additionally, please visit the Takeda Neuroscience Medical Affairs booth #228 or our virtual Medical Affairs booth experience at Sleep.Medical.TakedaNeuroscience.com

This program is not for CME credit and is consistent with the PhRMA Code on Interactions with Healthcare Professionals. The program is intended for healthcare professionals outside UK and US. Takeda does not have any approved treatments for narcolepsy.

Copyright © 2021 Takeda Pharmaceutical Company Limited. All Rights Reserved.

VV-MEDMAT-58994. 12/2021.

DOWNLOAD THE WORLD SLEEP 2022 APP View schedules, science, speakers and a lot more!

We are pleased to offer an interactive mobile app for World Sleep 2022. The app will allow you to view and search speaker names, sessions, rooms, and topics. It will also include details about social events such as the Opening Ceremony. The WORLD SLEEP 2022 app is available in the App Store and on Google Play.

Sponsored by

15 | Scientific Program | WORLD SLEEP 2022

GENERAL INFORMATION CONGRESS PROGRAM DATES

BADGE IDENTIFICATION

March 11-16, 2022

All congress participants and guests must wear a World Sleep 2022 congress badge. Badges allow entrance to the scientific sessions and access to the convention center. Your cooperation with this policy is appreciated. Recycle your badge holder after the congress by dropping it off at the registration desk.

Replacement badges can be obtained at the registration desk for a fee.

VENUE & LOCATION Roma Convention Center La Nuvola Viale Asia, 40, 00144 Roma RM, Italy romaconventiongroup.it La Nuvola—or “the cloud”—stands in beautiful contrast with the surrounding EUR business district designed in the 1930s.

Counterpointing the dominant architectural rationalism of that time, La Nuvola projects a feeling of fluidity and collaboration with its glass façade and curving lines within. The EUR district itself will be a worthwhile visit, with its fine museums and open spaces, and is a handful of Rome Metro stops from classic tourist destinations and the center of the city.

CONTINUING MEDICAL EDUCATION (CME) World Sleep Society will apply to offer CME credits at World Sleep 2022. Attendees will be responsible for purchasing the $25 CME fee, recording their activities and submitting them to World Sleep Society for processing. The final number of CME credits available at World Sleep 2022 is to be determined. Thirty-nine credits were available at World Sleep 2019 Vancouver.

COVID-19 We are committed to ensuring the safety and comfort of our attendees at World Sleep 2022. The congress will be following all requirements set by the Italian authorities during our congress dates of March 11–16, 2022. In addition, testing is available on site at the congress. A protocol is in place for attendees who test positive, including reserved hotel rooms at subsidized rates, transportation to the hotel, and connection with a healthcare provider for a letter of recovery. For the latest information, please visit the World Sleep Society information booth or worldsleepcongress.com

MEMBERSHIP World Sleep Society membership records can be reviewed and memberships purchased at the registration desk. Learn more about membership benefits at worldsleepsociety.org

REGISTRATION DESK Registration materials (bags, final programs, tickets, etc.) will be provided at the registration desk located at the entrance to Roma Convention Center La Nuvola. Tickets are required for entry to the gala dinner and to pre-congress courses on Friday, Saturday, and Sunday. Tickets can be purchased online or at the registration desk.

REGISTRATION DESK HOURS Friday: 4:00pm to 8:00pm Saturday: 7:00am to 6:00pm Sunday: 7:00am to 6:00pm Monday: 7:00am to 6:00pm Tuesday: 7:00am to 6:00pm Wednesday: 7:00am to 6:00pm

EXHIBIT HALL HOURS Monday: 9:30am–4:00pm Tuesday: 9:30am–4:00pm Wednesday: 9:30am–2:00pm Exhibition will be closed and monitored by security before 8:30am and after 5:00pm.

PRESS ROOM Members of the press are able to use the speaker ready room to work and access the internet.

16 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

GENERAL INFORMATION SPEAKER READY ROOM

ELECTRONIC DEVICES

A speaker ready room will be available to presenters to upload their presentations, test software, and make changes to their presentations. Speakers are required to upload their presentations in the speaker ready room at least 12 hours prior to their session. A technician will be available in room 34 to assist as needed.

Please turn all electronic devices (phones, pagers, etc.) to silent mode during presentations. As a courtesy to the presenters and audience, phone calls should be taken outside of the scientific sessions.

SEATING Scientific sessions are filled on a first-come, first-served basis.

World Sleep Society and the Program Committee reviewed the scientific sessions to anticipate demand and match the room size with expected seating. Occasionally, a presentation will have higher demand than expected. We encourage delegates to arrive early for the best possible seating.

SPEAKER READY ROOM HOURS ROOM 34 Saturday: 7:00am to 5:00pm Sunday: 7:00am to 5:00pm Monday: 7:00am to 5:00pm Tuesday: 7:00am to 5:00pm Wednesday: 7:00am to 5:00pm

RECORDING DEVICE POLICY No recording devices, audio or visual, may be used during CME activities. Duplication, distribution, or excerpting of this program without the express written permission of World Sleep Society is strictly prohibited. All of the proceedings of this program, including the presentation of scientific papers, are intended for limited publication only, and all property rights in the material presented, including common-law copyright, are expressly reserved by the Faculty, World Sleep Society, and/or CME provider. No statement of presentation made is to be regarded as dedicated to the public domain. Any sound reproduction, transcript, or other use of the material presented at this CME activity without the permission of World Sleep Society and CME provider is prohibited to the full extent of common-law copyright in such material.

Cameras and recording devices are not allowed to be used in the scientific meeting rooms at any time. Violation of this rule could result in removal from the congress along with the confiscation of the film and/or recording device.

WORLD SLEEP 2022 PROGRAM TYPES DS Discussion Symposium

S

Symposium

K

Keynote

P

C

Course

O

I

Industry Symposium

SE Social Event

Poster Abstract

E

Exhibition

AM Affiliated Meeting

Oral Abstract

T

Technologist Program

17 | Scientific Program | WORLD SLEEP 2022

A

Administration

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Discover what’s new about ResMed AirSense 11 at booth #540

AirSense 11 is exhibited for presentation purpose only - The product cannot be made available until compliance to applicable regulation and CE mark are obtained.

AirSense is a trademark of ResMed. Specifications may change without notice. © 2022 ResMed.

202203 AirSense 11 pre-launch advert for WSD congress EMEA ENG.indd 1

ResMed.com/AirSense11

14/02/2022 12:09:56

The purpose of Idorsia is to discover, develop and commercialize innovative medicines to help more patients. www.idorsia.com

Reaching out for more Headquartered in Switzerland – a biotech-hub of Europe – Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.

TRANSPORTATION LEONARDO DA VINCI–FIUMICINO INTERNATIONAL AIRPORT Fiumicino Airport (FCO) is the largest airport in Rome. In addition to hotel shuttles, taxis, and car rentals, the airport also offers the Leonardo Express, a direct train service from the airport to Roma Termini station in the city center. The train takes about 30 minutes to reach the city center. Visitors can then enter the Rome Metro system at Roma Termini station to travel to the EUR District.

CIAMPINO–G. B. PASTINE INTERNATIONAL AIRPORT Ciampino Airport (CIA) is the smaller of the two international airports in Rome. In addition to hotel shuttles, taxis, and car rentals, the airport also offers the Ciampino Airlink, which is a combined bus-metro route to the city center. The Ciampino Airlink takes about 45 minutes to reach the city center. A bus route from the airport to the EUR District is also available.

ROMA CONVENTION CENTER LA NUVOLA Roma Convention Center La Nuvola is located in the EUR District in the south of Rome. The closest metro station to the venue is the EUR Fermi station, which is a few minutes’ walk from the venue. The city center is located about 20 minutes away via Rome Metro.

Roma Convention Center La Nuvola Viale Asia, 40, 00144 Roma RM, Italy romaconventiongroup.it

ROME METRO Located in the city center, Roma Termini is the main railway station for Rome and the city’s mass transit hub. The Rome Metro is split into three lines: A, B, and C. The congress venue is located a few minutes’ walk from Line B’s EUR Fermi station.

EUR Fermi is just over 20 minutes from the city center via Line B.

ADDITIONAL INFORMATION Find more information and links to official websites and maps at worldsleepcongress.com/transportation

20 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

metro, ferrovie metropolitane GETTING TO THE VENUE e tram Bracciano Vigna di Valle

Centro Rai

RE NULA O A ORD ACC E R D N GRA

Cesano Olgiata

fiume Tevere

Mancini

Ottavia

ROMA Giardinetti

ferrovie regionali/regional railways FL1

Nuovo Salario

GRA ND E

FL5 FL6

AN UL AR E

FL7 FL8

19

Jonio

Campi Sportivi

2

Conca Conca d’Oro

Acqua Acetosa 2

Balduina Appiano Proba Petronia

19

3.

TIBURTINA

Piazza del Popolo

2

Spagna

19

BOLOGNA Castro Pretorio Repubblica Repubblica

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SAN GIOVANNI Lodi Re di Roma

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Quattro Venti

Furio Camillo Colli Albani

LARE ANU DO COR RAC DE AN GR

Garbatella Garbatella

Villa Bonelli

BASILICA SAN PAOLO

Magliana Muratella

EUR MAGLIANA

Ponte Galeria

BASILICA SAN PAOLO Marconi

EUR MAGLIANA

Parco Appia Antica

Tor di Valle

Parco Leonardo

EUR FERMI Laurentina Eur STATION Palasport

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ROMA Giardinetti

Caserta Cassino Frosinone

Tor Vergata

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tratta sospesa

Arco di Travertino Porta Furba-Quadraro Numidio Quadrato Lucio Sestio Guilio Agricola Giulio Subaugusta Cinecittà Anagnina

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Fiera di Roma

Vle P.Togliatti

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OSTIENSE

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PORTA SAN PAOLO

3

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Tivoli Avezzano

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5.14

Manzoni

3

Lunghezza Ponte di Nona

Porta Maggiore

3

Museo della Liberazione

8

19

Te

Colosseo

Salone

La Rustica UIR

S.Bibiana

Vittorio Emanuele

8

Tor TorSapienza Sapienza Sapienza

3.

e

m 8

La Rustica Città Tor

Serenissima

5 14

Venezia

Palmiro Togliatti

Prenestina

TERMINI TERMINI STATION Laziali Cavour

fiu

Civitavecchia Grosseto

Casal Bernocchi Centro Giano

fiu

Pietralata

Fontana Trevi

SAN PIETRO

FL5

Quintiliani

Santa Maria del Soccorso

Policlinico

Teatro Opera Teatro Opera

Barberini

Ponte Mammolo

Monti Tiburtini

3.

Risorgimento

Aurelia

parcheggi di scambio/parking Aurelia limite di validità della tariffa urbana metrebus Roma/limit of Rome metrebus tickets

Rebibbia

FLAMINIO

Lepanto

Cipro

collegamento bus con aeroporto Ciampino/bus connection with Ciampino airport

S.Agnese Annibaliano

Valle Giulia 19

Musei Vaticani

linee tram/ tram lines

interscambio ferrovie nazionali/interchange with national railways

Nomentana

3

orte/fara sabina - fiumicino aeroporto tivoli - roma tiburtina viterbo/cesano - roma tiburtina albano/frascati/velletri - roma termini civitavecchia - roma termini frosinone - roma termini latina - roma termini nettuno - roma termini fiumicino aeroporto - roma termini

capolinea bus extraurbani/interchange with suburban buses

d’Oro

Libia

Euclide 19

Ottaviano S.Pietro

VALLE AURELIA

Baldo degli Ubaldi

GRANDE RACCORDO ANULARE

Acilia

Pomezia - S. Palomba

Ostia Antica Lido Nord

f-XXI

RA CCO RD O

FL4

Monte Antenne

2

Gemelli

logistica di rete

FL2 FL3

Tor di Quinto

Monte Mario

Leonardo Express

ROMA Lido

Leonardo Express

San Filippo Neri

FIUMICINO AEROPORTO

monte compatri/pantano - san giovanni

ferrovie urbane/urban railways

Saxa Rubra

Ipogeo degli Ottavi

FL1

metro linea C

Due Ponti Ponti Due

La Giustiniana

Casaletto

laurentina - rebibbia laurentina - jonio

Fidene

Grottarossa

La Storta - Formello

Cornelia

metro linea B e B1

Fara Sabina - Montelibretti Piana Bella di Montelibretti Monterotondo - Mentana Settebagni

ROMA Viterbo

Anguillara

Battistini

anagnina - battistini

FL1 Orte

fiume Tevere

Viterbo

legenda/key to symbols metro linea A

Viterbo Sacrofano Montebello La Giustiniana Prima Porta La Celsa Labaro

ROMA Viterbo

FL3

Lido Centro Stella Polare Castel Fusano Cristoforo Colombo

LEONARDO DA VINCI–FIUMICINO INTERNATIONAL AIRPORT

CAMPOLEONE Aprilia Campo di Carne FL8

ROMA Lido

Nettuno

FL7

Latina Formia

CIAMPINO Casabianca S.Maria delle Mole Pavona Cancelliera Cecchina Lanuvio S.Gennaro

FL4

Marino Laziale Castel Gandolfo Villetta Albano Laziale

S.Eurosia Velletri

Frascati

Acqua Acetosa Sassone Pantanella

FL4 FL4

LEONARDO EXPRESS TRAIN

21 | Scientific Program | WORLD SLEEP 2022

CIAMPINO–G. B. PASTINE INTERNATIONAL AIRPORT

HOTELS HOTELS Ega Worldwide Congress & Events is the contracted partner for hotel bookings. Ega have provided a booking platform with information about rates, locations, and travel times to the venue for 31 hotels in the city center and near the venue. These rates are fixed and the reservations will come with additional customer support from Ega, who will have staff at the congress to assist with hotel bookings. Access the hotel booking platform at worldsleepcongress.com/hotel

HOTELS NEAR CITY CENTER 11 12 13 14

Attendees can also book their own hotels independently, but these bookings cannot be guaranteed or supported by Ega.

15

HOTELS NEAR EUR DISTRICT

16

1

Pulitzer Roma hotelpulitzer.it/en

17

2

Hotel dei Congressi hoteldeicongressiroma.com/en/home-eng

18

3

Ibis Styles Roma Eur all.accor.com/hotel/9301/index.en.shtml

19

4

American Palace Eur americanpalace.it/en

20

5

Villa Eur Parco dei Pini villaeur.com/en

21

6

Warmhotel warmthotel.it/en/index

22

7

Novotel Roma Eur all.accor.com/hotel/9299/index.en.shtml

23

8

Shangri-la shangrilaroma.it/en

24

9

Cristoforo Colombo hotelcolomboroma.it/en

25

10 Sheraton Parco de’ Medici

marriott.com/hotels/travel/romps-sheratonparco-de-medici-rome-hotel

26 27 28 29 30

Mercure all.accor.com/hotel/2909/index.en.shtml St. Martin stmartinroma.com/en The Tribune tribunehotel.it Mascagni mascagnicollection.com/mascagni-hotel/en Quirinale hotelquirinale.it/en Nord Nuova Roma hotelnordnuovaroma.it/en Mediterraneo romehotelmediterraneo.it/en Torino hoteltorinoroma.it/en Morgana hotelmorgana.com/en Ariston hotelariston.it/en DoubleTree by Hilton Rione Monti hnh.it/en/hotel/doubletree-by-hilton-rome-monti Mercure Roma Centro Colosseo all.accor.com/hotel/2909/index.en.shtml Kolbe kolbehotelrome.com Palatino fhhotelgroup.it/en/grand-hotel-palatino-roma/index The Glam aghotels.it/en/the-glam/index Forum hotelforum.com/en Pace Helvezia hotelpacehelveziaroma.it/en Imperiale hotelimperialeroma.it/en Stendhal & Stendhal Luxury Suites hotelstendhalrome.com Genio hotelgenioroma.it/en

22 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

ROME MAP OVERVIEW See list of hotels on previous page. Book your hotel through Ega at worldsleepcongress.com/hotel

HOTELS NEAR CITY CENTER 13 30

28-29

12

11

14-21 24-27

23

22

HOTELS NEAR EUR DISTRICT 1 3 10

LEONARDO DA VINCI–FIUMICINO INTERNATIONAL AIRPORT

2

7-9 5 6

4

WORLD SLEEP 2022 ROMA CONVENTION CENTER LA NUVOLA

23 | Scientific Program | WORLD SLEEP 2022

CIAMPINO–G. B. PASTINE INTERNATIONAL AIRPORT

ROME, ITALY WHEN IN ROME Rome is known for its unparalleled history. It attracts visitors wishing to discover the city’s striking monuments and archaeological sites while enjoying its renowned cuisine and sparkling atmosphere. With attractions such as the Colosseum, the Roman Form and Circus Maximus, visitors can get a taste of a rich history full of gladiators in an arena, chariots crashing during a wild race and Roman public life once upon a time.

TRIPADVISOR’S TOP 10 THINGS TO DO IN ROME ITALY

ART HISTORY AND HUMANITIES IN SLEEP

5. Piazza Navona

World Sleep 2022 will provide a unique course that explores the intersection of sleep and the arts. The course will conclude with a walking tour of an art museum in Rome to see firsthand the brilliant creations of artists over the centuries. Chaired by Sonia Ancoli-Israel and Meir Kryger, the course will take place on March 11, 2022.

6. Basilica di Santa Maria Maggiore

VISIT THE VATICAN No matter your faith tradition, Vatican City presents an outstanding opportunity to see and experience firsthand some of the most recognizable foundations of European art and architecture. From the open St. Peter’s Square to the art housed in the Vatican Museums, consider making time for this special destination during your time in Rome.

1. Pantheon 2. Colosseum 3. Roman Forum 4. Palatine Hill

7. Trevi Fountain 8. Galleria Borghese 9. Trastevere 10. Museo Nazionale di Castel Sant’Angelo To learn more about Rome tourism visit turismoroma.it/en.

TOURS Ega Worldwide Congress & Events will be organizing and offering tour packages to experience Rome. Visit the registration desk for more information.

24 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

NETWORKING & SOCIAL EVENTS One of the unique strengths of World Sleep 2022 will be the diversity and breadth of attendance. Previous congresses have attracted attendees and exhibitors from dozens of countries and many hundreds of institutions. Connect with colleagues, learn about the latest developments and build your network worldwide with the opportunities found in Rome during March 11–16, 2022.

Sponsored by

Sponsored by

OPENING CEREMONY & RECEPTION

POSTER SESSIONS

SUNDAY | 6:30–8:00PM The Opening Ceremony of World Sleep 2022 will feature a program overview, award presentations, and a reception.

MONDAY | 5:30–7:00PM • TUESDAY | 5:30–7:00PM Browse poster abstracts and discuss upcoming research methods and findings with investigators in a more open, personal format.

Sponsored by

GALA DINNER MONDAY | 7:00–11:00PM Purchase a ticket to join us at the Gala Dinner on Monday evening. Plan for a night of fine food, entertainment and conversation with friends.

WORLD SLEEP SOCIETY MEMBERSHIP MEETING TUESDAY | 7:05–7:55AM | ROOM 21 All attendees of World Sleep are welcome to attend this meeting.

WORLD SLEEP DAY DELEGATE MEETING

Sponsored by

CLOSING CEREMONY & RECEPTION WEDNESDAY | 6:15–8:00PM All attendees and exhibitors are invited to join the Closing Ceremony. Catch up with your colleagues about what caught your interest during the congress and stay for a special presentation from the hosts of World Sleep 2023 in Rio de Janeiro, Brazil.

MONDAY | 1:00–2:00PM | ROOM 31 Join the networking meeting for World Sleep Day. As World Sleep Day continues to grow, our Delegates continue to organize creative and impactful activities to raise awareness of healthy sleep. You don’t have to be a delegate to join the meeting. Join us to learn strategies for organizing and connect with others who can help.

ITALIAN ASSOCIATION OF SLEEP MEDICINE (AIMS) ANNUAL MEETING

EXHIBIT HALL World Sleep 2022 will feature exhibitors from companies and organizations around the globe. Browse the exhibit hall to meet new people and see the latest developments of interest to professionals in sleep medicine and research.

FRIDAY | 1:00PM - 7:00PM | ROOM 11 SATURDAY | 8:30AM - 5:30PM | ROOM 11 The annual Italian Association of Sleep Medicine (AIMS) meeting will be Saturday and Sunday. Seperate ticket is required. For additional information visit sonnomed.it

Sponsored by

INTERNET CAFE Located near registration on level 1.

25 | Scientific Program | WORLD SLEEP 2022

2022 AWARDS YOUNG INVESTIGATOR AWARD FOR ORAL AND POSTER ABSTRACT PRESENTATIONS Young Investigator Awards will be offered to qualifying individuals at World Sleep 2022 Rome. Oral abstract awards will provide the opportunity for up to 18 individuals to present their abstract during a special young investigator oral abstract session. Poster awards will be presented to authors of the top-ranked young investigator poster abstracts.

2022 YOUNG INVESTIGATOR AWARD RECIPIENTS Michal Kahn (Australia) Sleepless on the road: Are mothers of infants with pediatric insomnia at risk for impaired driving?

Hilde T. Juvodden (Norway) Larger hypothalamic volume in histamine neuron area in narcolepsy type 1 Mariana Fernandes (Italy) Cerebrospinal-fluid biomarkers and blood-brain barrier alteration may be useful to predict the phenoconversion of patients with idiopathic/isolated REM sleep behaviour disorder

Miranda G. Chappel-Farley (United States) Obstructive sleep apnea-related blood oxygen desaturation is associated with preferential consolidation of negative memories in older adults Oliver Piltch (United States) Changes in Sleep Architecture During Long-Duration Spaceflight Marie Gombert (Spain) The circadian expressions of metabolism genes in human adipocytes: the impact of melatonin Hyeon Jin Kim (Korea, Republic of) Chronotype advance as a predictor of subsequent cognitive function and brain volume regression: a 4-year longitudinal cohort study Laetitia S. Gaspar (Portugal) Obstructive sleep apnea impact on physiology: insights from a mouse model and a case-control study Luca Baldelli (Italy) Epigenetic clocks suggest accelerated ageing in isolated REM Sleep Behavior Disorder patients

Mathieu Berger (Switzerland) Association of sleep microstructure with incident hypertension in a population-based sample: The HypnoLaus study

Carlos Carrera-Cañas (Spain) Hypocretin Release and Plasticity of Hypocretinergic Receptors in a Pharmacological Model with Narcolepsylike Features Induced by Suvorexant in Rats

Beatrice Orso (Italy) Identification and validation of a brain glucose metabolism conversion pattern in idiopathic REM Behaviour Disorder

Sarah Schoch (Netherlands) Interactions between sleep and gut bacteria in healthy developing infants

Andrea Donniaquio (Italy) Anti-hypothalamic autoantibodies in patients with Narcolepsy

Salla Hietakoste (Finland) Desaturation severity affects OSA-related changes in short-term heart rate variability

Yumeng Huang (China) Map2k5 deficient mice manifest phenotypes and pathological changes of dopamine deficiency in the central nervous system

Shady Rahayel (Canada) Brain atrophy in REM sleep behavior disorder is shaped by gene expression and structural connectivity Mingming Wang (Germany) Longitudinal associations of insufficient sleep duration and insomnia with obesity from adolescence to young adulthood in the GINIplus and LISA studies

26 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

2022 AWARDS

CHRISTIAN GUILLEMINAULT YOUNG INVESTIGATOR AWARD The Christian Guilleminault Young Investigator Awards are presented to encourage young investigators in the field of sleep, especially in developing portions of the world, to advance sleep medicine and research worldwide. Up to 2 awards of $1,000 will be offered to qualifying individuals.

2022 CHRISTIAN GUILLEMINAULT YOUNG INVESTIGATOR AWARD RECIPIENTS

Mariana Fernandes (Italy) Cerebrospinal-fluid biomarkers and blood-brain barrier alteration may be useful to predict the phenoconversion of patients with idiopathic/isolated REM sleep behaviour disorder Sarah Schoch (Netherlands) Interactions between sleep and gut bacteria in healthy developing infants

ELSEVIER AWARDS Elsevier has established two scientific awards for new basic and clinical sleep specialists in honor of Christian Guilleminault and Elio Lugaresi. Two awards of $1,000 will be presented at World Sleep 2022.

WAYNE HENING YOUNG INVESTIGATOR AWARDS Wayne Hening Young Investigator Awards are presented to young investigators in the RLS/PLMS field. Up to five awards of $1,000 will be offered to qualifying individuals.

2022 WAYNE HENING YOUNG INVESTIGATOR AWARD RECIPIENTS Philip Harrer (Germany) Methylglyoxal – a central metabolic factor in restless legs syndrome?

Tae-Joon Kim (Korea, Republic of) Quantitative susceptibility mapping as an indicator for the efficacy of intravenous iron therapy in restless legs syndrome Yumeng Huang (China) Association of BST1 polymorphism with idiopathic restless legs syndrome in Chinese population Chia-Luen Leu (Germany) A mouse model of RLS with aberrant cortical rhythms Maria P. Mogavero (Italy) Structural Changes of the Subcortical Gray Structures in Restless Legs Syndrome

2022 YOUNG INVESTIGATOR AWARD RECIPIENTS ELIO LUGARESI AWARD FOR SLEEP MEDICINE Alexander Sweetman (Australia) Do symptoms of depression, anxiety or stress impair the effectiveness of cognitive behavioural therapy for insomnia?

A chart-review of 455 patients with chronic insomnia CHRISTIAN GUILLEMINAULT AWARD FOR SLEEP RESEARCH Nicholas Kuzik (Canada) Machine learning sleep duration classification in Preschoolers using waist-worn ActiGraphs 27 | Scientific Program | WORLD SLEEP 2022

Visit booth 710

for narcolepsy insights, information, and resources for your patients

Learn more at NarcolepsyDisrupts.com

Not an actual patient.

References: 1. Mohsenin V. Narcolepsy—master of disguise: evidence-based recommendations for management. Postgrad Med. 2009;121(3):99-104. 2. Bassetti CLA, Kallweit U, Vignatelli L, et al. European guideline and expert statements on the management of narcolepsy in adults and children. Eur J Neurol. 2021;28(9):2815-2830.

CNS Pharmaceuticals, LLC © 2021 Avadel. All rights reserved. PM-US-SXB-0365 28 | ForAvadel the latest updates, visit WORLDSLEEPCONGRESS.COM

YOUR TRUSTED SOURCE FOR IMPROVING SLEEP A MAGAZINE PUBLISHED BY WORLD SLEEP SOCIETY Join the 18,000 individuals, sleep clinics, hospitals, and other professional sleep businesses receiving Healthier Sleep Magazine to their inboxes.

• Instant online access available

ISSUE TOPICS

• DAYTIME SLEEPINESS • RESTLESS LEGS SYNDROME • SNORING & OSA • BETTER SLEEP • FUTURE OF SLEEP • BABY & SLEEP

• Up to six issues per year, each issue highlighting a different subtopic in sleep We are a trusted source within the sleep community, now bringing our worldwide expertise to the patient level.

Welcome to Healthier Sleep.

IN EVERY ISSUE For more information or to subscribe for free, visit Healthiersleepmag.com

rld Sleep Day

Hosted by World Sleep Society

SAVE THE DATE

MARCH 17, 2023

ABOUT

GLOBAL EVENT

World Sleep Day is an annual event intended to be a celebration of sleep and a call to action on important issues related to sleep. Hosted by World Sleep Society, it is an opportunity for sleep experts to inform the public about the importance of sleep in all aspects of health.

Delegates in countries around the world participate in World Sleep Day each year by holding in-person, online, and media events that promote healthy sleep.

worldsleepday.org

twitter.com/_WorldSleep

SAVE THE DATE The next World Sleep Day is Friday, March 17, 2023. Sign up for updates at worldsleepday.org to follow the latest developments regarding the annual theme and activities.

facebook.com/wasmf

29 | Scientific Program | WORLD SLEEP 2022

KEYNOTE SPEAKERS 30 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

2022 KEYNOTE SPEAKERS

MONDAY | 8:00–8:45AM

MONDAY | 2:00–2:45PM

Room 11

Room 11

Phyllis C. Zee, MD, PhD (United States)

Monica Levy Andersen, PhD (Brazil)

K01: Circadian clocks: Medicine in the fourth dimension

K03: Do females sleep better? Insights from basic and clinical studies

Benjamin and Virginia T. Boshes Professor in Neurology Director, Center for Circadian and Sleep Medicine Chief, Division of Sleep Medicine – Neurology Northwestern University Feinberg School of Medicine, United States This keynote presentation will discuss the latest research in circadian rhythms and chronomedicine.

Room 24 Giuseppe Plazzi, MD, PhD (Italy)

Chair, Child Neurology, University of Modena and Reggio Emilia | Director of the Sleep Disorders, Narcolepsy and CNS Hypersomnias Center, IRCCS - Institute of Neurological Sciences of Bologna, Italy K02: Pediatric narcolepsy: Clinical features and burden of illness Compared to adults, narcolepsy symptoms often initially manifest differently in children and adolescents, which may pose diagnostic dilemmas. Insufficient sleep and circadian rhythm disorders presenting with excessive daytime sleepiness are also common in adolescents, potentially further confounding narcolepsy diagnosis. Pediatric narcolepsy presents distinct challenges in diagnosis and management, and it is associated with a considerable burden of illness, which is exacerbated by delays in symptom recognition, diagnosis, and intervention.

Associate Professor, Director of Sleep Institute, Vice-chair of Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Brazil

Women’s relationship with sleep can be complex, and is very different from that of men. During a woman’s life, the risk of developing sleep disorders, such as insomnia and sleep fragmentation, and experiencing disruption of their circadian rhythms, markedly increases for a number of reasons, including hormonal changes, societal pressures, and family responsibilities. The aim of this presentation is to review some differential aspects of sleep in females, to look at the basic science and current clinical practice, and to understand how sleep can change across the life of females, and how sleep deprivation impacts different aspects of female physiology.

Room 14 Nico de Vries, MD, PhD (Netherlands)

ENT surgeon at OLVG Hospital Amsterdam, Netherlands Professor of Dental Sleep Medicine at ACTA, Amsterdam, Netherlands Guest professor at University of Antwerp, Belgium K04: Sleep surgery: A viable alternative to CPAP and MAD treatment in OSA? Upper airway surgery is gradually developing into a viable alternative for CPAP and oral device therapy in well selected OSA patients. In particular, young self-responsible patients want to be well informed about potential alternatives to life-long CPAP or oral device therapy. In such cases, diagnostic work-up involves a comprehensive sleep study (as sleep surgeons look at it), OSA specific examination of the upper airway (in particular the collapsible segment of it) and Drug Induced Sleep endoscopy (DISE). Current surgical concepts focus on modern reconstructive techniques (as opposed to old resection techniques) and upper airway stimulation, and combined therapies.

Room 24 Yun-Kwok Wing, MBChB, MRCP, FRCP, FHKCP, FHKAM (Hong Kong)

Professor, Department of Psychiatry & Director of Li Chiu Kong Family Sleep Assessment Unit, Faculty of Medicine, The Chinese University of Hong Kong K05: Sleep and psychiatric disorders: From epidemiology to treatment Sleep and circadian problems have long been recognized as closely related to psychiatric disorders. The contribution of epidemiological studies in both clinical and general population, for example, in finding a reciprocal and bidirectional relationship between insomnia and depression has contributed to our conceptual shift to re-consider sleep disturbances as an independent comorbidity rather than a secondary symptom.

Along with this paradigm shift, the resultant proper recognition and treatment of comorbid sleep and circadian disturbances has improved the depression outcome. The comorbid concept has also provided a new direction of prevention medicine from sleep perspective: Can we prevent depression by targeting sleep problems? Can we prevent insomnia? Can we prevent neurodegeneration by targeting sleep and psychiatric disorders?

31 | Scientific Program | WORLD SLEEP 2022

2022 KEYNOTE SPEAKERS

TUESDAY | 8:00–8:45AM

TUESDAY | 2:00–2:45PM

Room 11

Room 11

Michael Gradisar, PhD (Australia)

Colin Espie, PhD (United Kingdom)

Professor of Clinical Child Psychology Flinders University, Australia

K06: Treating insomnia in school kids: How does it work?

The International Classification of Sleep Disorders, 3rd edition, recognises that Chronic Insomnia Disorder is not only applicable to adults, but also to children. Yet, it could be said that the majority of work investigating insomnia and its treatment lies at both ends of the lifespan: babies and adults.

There is little recognition that insomnia can occur in between these developmental stages—especially in middle childhood (7-12 yrs). This talk will show the similarities and differences of the insomnia experience in children, how CBT for insomnia has been adapted for them, and what underlying mechanisms may be at play.

Professor of Sleep Medicine, Clinical Director Experimental & Clinical Sleep Medicine Programme, Sleep & Circadian Neurosciences Institute, University of Oxford, United Kingdom K08: Delivering clinical guideline care for insomnia: The potential of digital therapeutics to close the treatment gap Cognitive behavioural therapy (CBT) is the guideline treatment of first choice for chronic insomnia, yet it is available to only a very small fraction of those who might benefit from it. As a result, pharmacotherapy, regarded as a less effective, second line intervention, continues to fill the insomnia treatment void. However, the emergence of fully automated digital CBT provides the opportunity to completely close this gap.

As part of a stepped care model of service provision, digital therapeutics may result in clinical guideline care becoming the norm in routine practice.

Room 14

Room 24 Luigi Ferini-Strambi, MD, PhD (Italy)

Full Professor of Neurology, Università Vita-Salute San Raffaele, Italy K07: Restless legs syndrome: A complex night-day disorder Restless legs syndrome (RLS)/Willis-Ekbom disease is one of the most common neurological disorders, with severe sleep disturbance and daily functioning impairment. RLS may be primary (idiopathic) or secondary to a variety of systemic disorders. The pathogenesis of RLS remains not fully clear, even if our understanding of the disease has improved by genetic and neuroimaging studies and by the development of animal models. A clinical approach to RLS management includes the identification of reversible contributing factors and the use of nonpharmacological and pharmacological treatment. The longterm effects of specific drugs for RLS suggest some changes in the optimal care management. The great socioeconomic impact of RLS related to the inadequate diagnosis and treatment has been recently reported.

Alex Iranzo, MD, PhD (Spain)

Senior Consultant, Neurology Service Multidisciplinary Sleep Unit of the Hospital Clinic of Barcelona, Associate Professor, University of Barcelona School of Medicine, Spain K09: The isolated form of REM sleep behavior disorder as an opportunity for a neuroprotective intervention There is solid evidence that isolated REM sleep behavior disorder (IRBD) represents in most if not all patients an early manifestation of the synucleinopathies Parkinson’s disease and dementia with Lewy bodies. Most patients with IRBD show the presence of synuclein in the cerebrospinal fluid and with lesser frequency in the peripheral organs. In IRBD, abnormal DATSPECT and hyposmia are associated with an increased short term to develop dementia and parkinsonism. There is a need to implement a neuroprotective clinical trial in IRBD to prevent the onset of parkinsonism and dementia, perhaps using DAT-SPECT and smell as biomarkers of progressive neurodegeneration and targeting synuclein with immunotherapy against the propagation of this protein in the brain.

Room 24 Amita Sehgal, PhD (United States)

John Herr Musser Professor of Neuroscience, Investigator of the Howard Hughes Medical Institute & Director of the Chronobiology and Sleep Institute (CSI) University of Pennsylvania, United States K10: Why we need to sleep: Insights from a small animal model The function of sleep remains a mystery. There is universal agreement that lack of sleep impairs performance, especially cognitive ability, during waking hours and considerable evidence supports adverse effects of sleep loss on other physiological parameters as well. Thus, sleep may be regarded as important for waking function. However, what happens during sleep to facilitate wake performance and promote health? Some studies posit that replay of wake experiences in specific brain regions during sleep helps in memory consolidation, but it is likely that sleep affects fundamental physiology on a brain-wide and perhaps even bodywide level. Ongoing research seeks to address this question by investigating cellular and molecular processes impacted by sleep.

32 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

2022 KEYNOTE SPEAKERS

WEDNESDAY | 8:00–8:45AM

WEDNESDAY | 2:00–2:45PM

Room 11

Room 11

Thomas Scammell, MD (United States)

Danny Eckert, PhD (Australia)

Professor of Neurology, Beth Israel Deaconess Medical Center, Boston Children’s Hospital | Harvard Medical School, United States K11: Narcolepsy: From basic sciences to therapeutic approaches Narcolepsy is one of the more common causes of chronic sleepiness, yet until about 20 years ago, the cause of narcolepsy was essentially unknown. The discovery that narcolepsy is caused by a selective and severe loss of the orexin/hypocretin neurons has transformed our understanding of this disorder and is now leading to more effective therapies. Dr. Scammell will provide an overview of the neurobiology of narcolepsy; how loss of orexin signaling causes chronic sleepiness and cataplexy; and how this improved understanding is helping drive the development of novel therapies that target this fundamental orexin deficiency.

Room 24 Tracey Sletten, PhD (Australia)

Senior Research Fellow, Turner Institute for Brain and Mental Health | School of Psychological Sciences Monash University, Australia K12: Sleep, shift work, and occupational health: Implications and interventions This presentation will feature current research on the adverse health and safety implications of circadian misalignment and sleep loss in numerous real-world and occupational settings, and practical countermeasures. This will highlight interindividual differences in circadian physiology and advances in our understanding of individual responses to altered sleep and work schedules, along with novel interventions for alertness management and circadian misalignment, particularly among shift workers.

Mathew Flinders Professor and Director, Adelaide, Institute for Sleep Health Flinders University, South Australia K13: Sleep apnea endotypes and implications for precision sleep medicine This presentation will cover the latest knowledge of the different OSA endotypes and their role in advancing OSA pathogenesis and treatment. This will include development of new targeted therapies including combination therapy and pharmacotherapy, optimisation of existing therapies and clinically practical techniques to estimate OSA endotypes to deliver precision medicine for OSA at scale.

Room 24 Daniel J. Buysse, MD (United States)

UPMC Professor of Sleep Medicine, Professor of Psychiatry and Clinical and Translational Science, University of Pittsburgh School of Medicine, United States K14: Multidimensional sleep health: Measurement, consequences and interventions Sleep can be quantified along multiple dimensions such as regularity, subjective quality, daytime alertness/sleepiness, timing, efficiency and duration. These dimensions occur simultaneously in all individuals and are orthogonal to categorical sleep disorders. Numerous studies have documented adverse consequences associated with individual sleep characteristics such as sleep duration. However, the multidimensional sleep health (MDSH) perspective may offer more nuanced, more complex and more physiologically valid insights. This presentation will review the current status of reliability and validity of MDSH measurement; statistical approaches to examining MDSH; health outcomes related to MDSH; and interventions targeting MDSH.

33 | Scientific Program | WORLD SLEEP 2022

PROSOMNUS EVO

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Device advancement for further protrusion could not be easier for patients. It is definitely my go-to appliance for improved patient comfort and decreased chair time.”

Preference(2)

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Efficacy(1)

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Approximately equal mix of Mild, Moderate and Severe OSA patients

First time fit without adjustments

Average delivery appointments were consequently reduced by 15+ minutes

76%

– Katherine S. Phillips, DDS, MS, D-ABDSM, D-ABOP

“EVO has been a game changer for our practice. My patients love the comfort.

My team loves the ease of insertion and virtual elimination of follow up visits and/or remakes. This is the go-to device for our practice.”

– Brandon Hedgecock, DDS, D-ABDSM, D-ASBA

96%

100%

min

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The new front line of sleep apnea diagnostics.

35 | Scientific Program | WORLD SLEEP 2022

Save The Date Keynotes | Symposia | Courses | Oral Abstracts | Poster Abstracts | Breakout Discussions 7th Congress of the International Pediatric Sleep Association

IPSA ONLINE 2022 will provide an opportunity for physicians, clinicians, basic scientists, clinical investigators, educators and sleep health advocates from around the globe to present the latest cutting-edge research and explore innovative solutions to current challenges in pediatric sleep.

Program Schedule at a Glance

Pre-congress courses will be available on demand beginning October 27th.

Content will be launched in multiple time zones throughout the two-day virtual event.

Keynotes Lourdes DelRosso, MD, PhD (United States)

University of Washington Restless sleep disorder: Future directions for a novel diagnosis

Peter Franzen, PhD (United States)

Important Dates Symposium submission: January 15, 2022 to April 15, 2022

Abstract submission:

January 15, 2022 to May 15, 2022

University of Pittsburgh Sleep as a risk factor for depression and suicide in youth: A promising target for improving mental health?

Fan Jiang, MD, PhD (China)

Shanghai Jiao Tong University Sleep, developing brain and early childhood development

Register at pedsleep.org

Pediatric prolonged release melatonin The first and only proven and approved treatment for insomnia in the paediatric ASD population 1 Slenyto® significantly improves sleep: 2,3 Increases Total Sleep Time Shortens Sleep Latency Improves Longest Sleep Episode Improves Parents’ Quality of Life

Slenyto® is indicated for the treatment of insomnia in children and adolescents aged 2-18 with Autism Spectrum Disorder (ASD) and/or Smith-Magenis syndrome, where sleep hygiene measures have been insufficient.4 Reference: 1.https://www.ema.europa.eu/en/medicines/human/EPAR/slenyto 2. Gringras, P., et al., JAACAP 2017 56 (11) : 948-957 3. Maras A. et al., The Journal of Child and Adolescent Psychopharmacology. doi: 10.1089/cap2018.0020 4. Slenyto SmPC: https://www.ema.europa.eu/en/documents/product-information/ slenyto-epar-product-information_en.pdf

Good nights. Better days.

NLS Pharmaceutics symposium Wednesday, March 16th - 12:30pm to 2:00pm CET - room 22 Preliminary results on ongoing Phase IIa and Open Label Extension study with Mazindol ER for the treatment of narcolepsy.

37 | Scientific Program | WORLD SLEEP 2022

JOIN OUR SYMPOSIUM: CAN THE SLEEPING ENVIRONMENT BE OPTIMIZED TO IMPROVE SLEEP QUALITY? Speakers: Dr. Eve Van Cauter, Dr. Eus Van Someren and Dr. Virend Somers

During this event convened by sleep health leader Sleep Number, we will evaluate temperature modulation, light and noise exposure, and sleeping position within the sleeping environment to determine if they can be manipulated to improve sleep quality.

Monday, March 14, 12:30 – 2 pm (room 13) Visit us at booth #440 sleepnumber.com/science

Sleep Duration

Restful Sleep

Heart Rate

8.3 6.5 63 Average

h

Average

h

bpm

Average

Breathe Rate

16

bpm

Average

©2022 Sleep Number Corporation

Satellite Symposium World Sleep 2022 Tuesday, March 15, 2022 12:30 - 14:00 Join us at the satellite symposium titled Beyond the AHI, for an exciting discussion on some of the main challenges in sleep medicine today.

Chair

Speakers

Prof. Carolina Lombardi, Ph.D., MD

Prof.Dr. Christoph Schöbel, MD

Erna Sif Arnardóttir, Ph.D.

Eysteinn Finnsson

Associate Professor at the Dept of Cardiology

Center for Sleep Medicine at Ruhrlandklinik

Head of Sleep Disorder Center

University of Medicine Essen, Germany

Assistant Professor, Dept of Engineering and Dept of Computer Science

Research Engineer, Analysis, Data and Research

Director of The Reykjavik University Sleep Institute

Nox Medical

University of Milano -Bicocca, Italy

Reykjavik University, Iceland

LBL-0310 REV01

39 | Scientific Program | WORLD SLEEP 2022

31

st

National Congress

Italian Association of Sleep Medicine – AIMS –

FRIDAY, MARCH 11 • 13:00 – 19:00 SATURDAY, MARCH 12 • 08:30 – 17:30 ROMA CONVENTION CENTER LA NUVOLA • ROOM 11

AIMS ANNUAL MEETING ABOUT AIMS The Italian Association of Sleep Medicine (AIMS) is a multidisciplinary professional scientific society dedicated to promoting scientific research and clinical training in sleep medicine. In addition, AIMS promotes a more general awareness of sleep health and disorders among the Italian public.

Founded in 1990, AIMS currently has over 400 members and organizes an annual meeting.

ORGANIZING & SCIENTIFIC COMMITTEE Conference President Giuseppe Plazzi (Bologna – Modena) Dario Arnaldi (Genova) Giulio Alessandri Bonetti (Bologna) Enrica Bonanni (Pisa) Maria Rosaria Bonsignore (Palermo) Cinzia Castronovo (Milano) Luigi De Gennaro (Roma) Francesco Fanfulla (Pavia) Luigi Ferini Strambi (Milano) Raffaele Ferri (Troina – En) Sergio Garbarino (Genova) Biancamaria Guarnieri (Pescara) Michelangelo Maestri Tassoni (Pisa) Raffaele Manni (Pavia) Lino Nobili (Genova) Laura Palagini (Pisa) Monica Puligheddu (Cagliari) Alessandro Silvani (Bologna) Claudio Vicini (Forlì)

CME Italian CME credits will be provided.

PRIMARY CONGRESS TOPICS • PLMS

• BASIC SCIENCE OF SLEEP • NEW MARKERS IN OSA • NARCOLEPSY: FROM BASIC SCIENCES TO CLINICAL SLEEP MEDICINE • NON-VENTILATORY THERAPIES FOR OSA: WHEN, HOW, WHY 2021 • INSOMNIA

ORGANIZING SECRETARIAT AND CME PROVIDER

Viale Aldini 222/ 4 – 40137 Bologna – Italy congressi@avenuemedia.eu tel. + 39 051 6564300 avenuemedia.eu

40 | FOR MORE INFORMATION VISIT WORLDSLEEPCONGRESS.COM/AIMS

31

st

National Congress

Italian Association of Sleep Medicine – AIMS –

ANNUAL MEETING • FRIDAY, MARCH 11, 2022 13:00 – 19:00 • ROOM 11

12:00 – 13:00

REGISTRATION OF PARTICIPANTS

14:45 – 16:00

BASIC SCIENCE OF SLEEP

Chairs: Michele Ferrara (L’Aquila); Giovanna Zoccoli (Bologna)

13:00 – 13:30

OPENING LECTURES

Chair: Alfredo Berardelli (Roma)

The contribution of Sleep Medicine in Italy

Giuseppe Plazzi (Bologna); Luigi Ferini Strambi (Milano) 13:30 – 14:45

PLMS: TREATMENT IMPLICATIONS IN SLEEP AND NEUROLOGIC DISORDERS

Chair: Marco Zucconi (Milano); Enrica Bonanni (Pisa)

14:45 – 15:00

NEUROBIOLOGICAL MECHANISMS OF DREAM RECALL

Serena Scarpelli (Roma) 15:00 – 15:15

LOCAL SLEEP-LIKE SLOW WAVE INTRUSION DURING WAKEFULNESS: INSIGHTS FROM BRAIN-INJURED PATIENTS

Simone Sarasso (Milano) 15:15 – 15:30

PLMS TREATMENT: PRO AND CON

THE ROLE OF SLEEP IN RECOVERING FROM NATURAL AND SYNTHETIC TORPOR: A FOCUS ON TAU PROTEIN

13:45– 14:00

15:30 – 15:45

13:30 – 13:45

Marco Zucconi (Milano)

PLMS RESPONSIVENESS TO DRUG THERAPY

Mauro Manconi (Lugano - Switzerland) 14:00– 14:15

EFFECTS OF ANTIDEPRESSANTS ON PLMS

Raffaele Ferri (Troina – En) 14:15– 14:30

Marco Luppi (Bologna)

EEG ALTERATIONS DURING WAKE AND SLEEP IN MILD COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE

Aurora D’atri (L’Aquila) 15:45 – 16:00

DISCUSSION

PLMS AND OSA – ARE THEY INDEPENDENT?

Carolina Lombardi (Milan) 14:30 – 14:45

DISCUSSION

41 | AIMS ANNUAL MEETING 2022 | ROME, ITALY

31

st

National Congress

ANNUAL MEETING • FRIDAY, MARCH 11, 2022 13:00 – 19:00 • ROOM 11

Italian Association of Sleep Medicine – AIMS –

16:00 – 17:00

INDUSTRY LECTURES

16:00 – 16:30

RESIDUAL EDS IN OSA PATIENTS: THE SOLRIAMFETOL PROPOSAL

Claudio Liguori (Roma) With the contribution of Jazz Pharmecuticals 16:30 – 17:00

THE EMOTIONS OF PATIENTS WITH INSOMNIA DISORDER: FROM NEURAL CIRCUITS TO COVID-SOMNIA

Moderator: Michela Vuga (Milano) Speakers: Luigi De Gennaro (Roma), Lino Nobili (Genova), Laura Palagini (Pisa) With the contribution of Idorsia Pharmecuticals 17:00 – 19:00

GENERAL AIMS ASSEMBLY AND ELECTION OF NEW AIMS BOARD

42 | FOR MORE INFORMATION VISIT WORLDSLEEPCONGRESS.COM/AIMS

31

st

National Congress

ANNUAL MEETING • SATURDAY, MARCH 12, 2022 08:30 – 17:30 • ROOM 11

Italian Association of Sleep Medicine – AIMS –

10:15– 10:30

08:30 – 09:45

NEW MARKERS IN OSA

Chairs: Maria Pia Villa (Roma); Francesco Fanfulla (Pavia)

TELEMEDICINE FOR NARCOLEPSY

Francesca Ingravallo (Bologna) 10:30– 10:45

08:30 – 08:45

PHARMACOLOGICAL TREATMENT OF NARCOLEPSY

Maria Paola Mogavero (Pavia)

10:45– 11:00

IS THERE A PLACE FOR EPIGENETICS

08:45 – 09:00

NEW FUNCTIONAL MARKERS OF CARDIO-VASCULAR IMPAIRMENT

Martino Pengo (Milano) 09:00 – 09:15

VENTILATORY TREATMENT: IN SEARCH OF ALTERNATIVE OUTCOMES

Stefania Redolfi (Cagliari) 09:15 – 09:30

OBSTRUCTIVE SLEEP APNOEA (OSA) IN CHILDREN: AN UPDATE

Maria Pia Villa (Roma) 09:30 – 09:45

Claudio Liguori (Roma) DISCUSSION

11:00 – 11:15

COFFEE BREAK

11:15 – 12:30

NON-VENTILATORY THERAPIES FOR OSA: WHEN, HOW, WHY 2021

Chairs: Giulio Alessandri Bonetti (Bologna); Claudio Vicini (Forlì) 11:15 – 11:30

UPDATE ON MAD THERAPY

Chiara Stipa (Bologna)

DISCUSSION

11:30 – 11:45

09:45 – 11:00

NARCOLEPSY: FROM BASIC SCIENCES TO CLINICAL SLEEP MEDICINE

Chairs: Giuseppe Plazzi (Bologna); Maria Rosaria Bonsignore (Palermo) 09:45– 10:00

UPDATE ON EXPERIMENTAL DATA IN NARCOLEPSY

Alessandro Silvani (Bologna) 10:00 – 10:15

POLYSOMNOGRAPHIC DIAGNOSIS OF NARCOLEPSY AND CENTRAL DISORDERS OF HYPERSOMNOLENCE

SHORT AND LONG TERM SIDE EFFECTS OF MAD THERAPY

Luca Mezzofranco (Padova) 11:45 – 12:00

SURGERY, AN OVERVIEW OF THE AVAILABLE OPTIONS

Giovanni Cammaroto (Forli’) 12:00 – 12:15

OUTCOMES OF SURGERY IN AN EBM PERSPECTIVE

Alessandro Bianchi (Milano) 12:15 – 12:30

DISCUSSION

Fabio Pizza (Bologna)

43 | FOR MORE INFORMATION VISIT WORLDSLEEPCONGRESS.COM/AIMS

31

st

National Congress

Italian Association of Sleep Medicine – AIMS –

ANNUAL MEETING • SATURDAY, MARCH 12, 2022 08:30 – 17:30 • ROOM 11

12:30 – 13:00

15:15 – 16:15

INDUSTRY LECTURE

LECTURES

12:30 – 13:00

THE HISTAMINERGIC PATHWAY IN THE TREATMENT OF EXCESSIVE DAYTIME SLEEPINESS IN PATIENTS WITH OSA

Luigi Ferini Strambi (Milano) With the contribution of Bioprojet

15:15 – 15:45

FARPRESTO: THE ITALIAN REGISTRY OF REM BEHAVIOR DISORDER

Monica Puligheddu (Cagliari) 15:45 – 16:15

TRAVELLING IN THE SLEEP UNIVERSE: WHEN SCIENCE AND ART MEET (IN HONOR OF NANNI TERZANO)

13:00 – 14:00 LUNCH

Liborio Parrino (Parma)

14:00 – 15:15

16:15 – 17:30

INSOMNIA

Chairs: Lino Nobili (Genova); Luigi Ferini Strambi (Milano)

ORAL PRESENTATIONS

16:15 – 16:20 F. Salfi

16:50 – 16:55 C.A.M. Lo Iacono

16:20 – 16:25 M. Elbaz

16:55 – 17:00 M. Varma

16:25 – 16:30 A. Pascazio

17:00 – 17:05 C. Oliver

16:30 – 16:35 Veronica Della Godenza

17:05 – 17:10 M. Fernandes

16:35 – 16:40 F. Salfi

17:10 – 17:15 C. Lupo

INSOMNIA, CIRCADIAN RHYTHMS AND MENTAL HEALTH

16:40 – 16:45 D. Tesini

17:15 – 17:20 G. Didato

14:45 – 15:00

16:45 – 16:50 N. Hafid

17:20 – 17:30

14:00 – 14:15

PRE-SLEEP AROUSAL AND SLEEP QUALITY DURING THE COVID-19 LOCKDOWN IN ITALY: CROSS-SECTIONAL AND LONGITUDINAL AIMS STUDIES

Maurizio Gorgoni (Roma) 14:15 – 14:30

INSOMNIA IN PRIMARY CARE: A SURVEY CONDUCTED ON ITALIAN PATIENTS OLDER THAN 50 YEARS

Paola Proserpio (Milano) 14:30 – 14:45

Laura Palagini (Ferrara)

INSOMNIA IN CHILDHOOD: IMPACT ON DEVELOPMENT AND MENTAL HEALTH

Oliviero Bruni (Roma) 15:00 – 15:15

DISCUSSION 44 | AIMS ANNUAL MEETING 2022 | ROME, ITALY

DISCUSSION

31

st

National Congress

Italian Association of Sleep Medicine – AIMS –

FRIDAY, MARCH 11 • 13:00 – 19:00 SATURDAY, MARCH 12 • 08:30 – 17:30 ROMA CONVENTION CENTER LA NUVOLA • ROOM 11

AIMS ANNUAL MEETING SPONSORS GOLD LEVEL

SILVER LEVEL

BRONZE LEVEL

45 | FOR MORE INFORMATION VISIT WORLDSLEEPCONGRESS.COM/AIMS

46 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRIDAY

Course | Affiliate Meeting

SATURDAY

Courses | Affiliate Meetings

SUNDAY

Courses | Affiliate Meetings

MONDAY

Keynote Presentations | Symposia | Technologist Session Oral Abstracts | Industry Symposia | Affiliate Meeting Poster Presentations

TUESDAY

Keynote Presentations | Symposia | Oral Abstracts Industry Symposia | Poster Presentations

WEDNESDAY

Keynote Presentations | Symposia | Industry Symposia Technologist Sessions | Oral Abstracts

SCIENTIFIC CONTENT 47 | Scientific Program | WORLD SLEEP 2022

COURSE FACULTY COURSE COMMITTEE Sonia Ancoli-Israel, PhD (United States) University of California San Diego School of Medicine

Raffaele Ferri, MD (Italy)

Oasi Research Institute IRCCS, Troina

Dalva Poyares, MD, PhD (Brazil) Federal University of São Paulo

Course faculty listed in alphabetical order.

Sabra Abbott (United States)

Naima Covassin (United States)

Claudio Liguori (Italy)

Till Roenneberg (Germany)

Candice A. Alfano (United States)

Yves Dauvilliers (France)

Frank Lobbezoo (Netherlands)

Darlynn Rojo-Wissar (United States)

Fernanda Almeida (Canada)

Massimiliano de Zambotti (United States)

Matthew Maas (United States)

Thomas Roth (United States)

Anna L. Mackinnon (Canada)

Warren Ruehland (Australia)

Atul Malhotra (United States)

Scott Sands (United States)

Mauro Manconi (Switzerland)

Josee Savard (Canada)

Bryce Mander (United States)

Richa Saxena (United States)

Tami Martino (Canada)

Carlos Schenck (United States)

Kiran Maski (United States)

Richard Schwab (United States)

Diego Mazzotti (United States)

William Schwartz (United States)

Reena Mehra (United States)

Neomi Shah (United States)

Luca Menghini (Italy)

Katherine Sharkey (United States)

Milton Mermikides (United Kingdom)

Michael Silber (United States)

Francesca Milano (Italy)

Debra J. Skene (United Kingdom)

Maria Paola Mogavero (Italy)

Virend Somers (United States)

Gustavo Moreira (Brazil)

Kai Spiegelhalder (Germany)

David Neubauer (United States)

Ambra Stefani (Austria)

Christoph Nissen (Switzerland)

Katie Stone (United States)

Sara Nowakowski (United States)

Patrick Strollo (United States)

Judith Owens (United States)

Riva Tauman (Israel)

Laura Palagini (Italy)

Michael Thorpy (United States)

Sanjay Patel (United States)

Liat Tikotzky (Israel)

Martino Pengo (Italy)

Claudia Trenkwalder (Germany)

Thomas Penzel (Germany)

Lynn Marie Trotti (United States)

Jean Louis Pépin (France)

Olivier Vanderveken (Belgium)

Pierre Philip (France)

Aleksandar Videnovic (United States)

Daniel Picchietti (United States)

Meredith Wallace (United States)

Fabio Pizza (Italy)

John Winkelman (United States)

Giuseppe Plazzi (Italy)

Lisa Wu (Denmark)

Vsevolod Polotsky (United States)

Katharina Wulff (Sweden)

Federica Provini (Italy)

Gary Zammit (United States)

Winfried Randerath (Germany)

..................................................

Oliver Rawashdeh (Australia)

* Course and speaker information subject to change. Revised on February 15, 2022

Isaac Almendros (Spain) Ellemarije Altena (France) Ali Amidi (Denmark) Raouf Amin (United States) Sonia Ancoli-Israel (United States) Isabelle Arnulf (France) Ali Azarbazin (United States) Chiara Baglioni (Italy and Germany) Fiona Baker (United States) Lucie Barateau (France) Ferran Barbe (Spain) Maree Barnes (Australia) Kelly Baron (United States) Ruth Benca (United States) Lynn Bilston (Australia) Donald Bilwise (United States) Bjørn Bjorvatn (Norway) Doug Bradley (Canada) Marc Braem (Belgium) Oliviero Bruni (Italy) Maja Bucan (United States) Daniel J. Buysse (United States) Sean Cain (Australia) Francesco Cappuccio (United Kingdom)

Lourdes DelRosso (United States) Luciano Drager (Brazil) Danny Eckert (Australia) Jason Ellis (United Kingdom) Colin Espie (United Kingdom) Mario Fabiani (Italy) Carlos Flores-Mir (Canada) Julie Flygare (United States) Birgit Frauscher (Canada) Stephany Fulda (Switzerland) Diego Garcia-Borreguero (Spain) David Gozal (United States) Michael Gradisar (Australia) Michael Grandner (United States) Helena Hachul (Brazil) Elisabeth Hertenstein (Switzerland) Cathy Hill (United Kingdom) Max Hirshkowitz (United States) Nelly Huynh (Canada) Yuichi Inoue (Japan) Chandra Jackson (United States) Shahrokh Javaheri (United States) Girardin Jean-Louis (United States) Ama Johal (United Kingdom)

Mercedes Carnethon (United States)

Dayna Johnson (United States)

Colleen Carney (Canada)

Elizabeth Klerman (United States)

Mary Carskadon (United States)

Meir Kryger (United States)

Matteo Cesari (Austria)

Leon Lack (Australia)

Maria Clotilde Carra (France)

Yue Leng (United States)

Christopher Colwell (United States)

Albert Martin Li (Hong Kong)

Dieter Riemann (Germany)

48 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

COURSE CATALOG Find complete course programs on the following pages.

FRIDAY

SUNDAY

COURSE | 10:00AM–2:00PM C01

Art history and humanities in sleep: Morning course and walking tour of museum

SATURDAY COURSES | 8:00AM–5:00PM | FULL DAY C02

Pediatric sleep

C03

Obstructive sleep apnea: Diagnosis and management

C04

The myths and science of dental sleep medicine

C05

Circadian (dys)function in health and disease

COURSES | 8:00AM–5:00PM | FULL DAY C12

Sleep health in women

C13

Year in review

C14

Aging, neurodegeneration and sleep

C15

Cardiovascular consequences of sleep apnea: What is new?

COURSES | 8:00AM–12:00PM | AM HALF DAY

COURSES | 8:00AM–12:00PM | AM HALF DAY C06

How to conduct epidemiological studies of sleep

C07

Recent advances in RLS treatment

C08

Present and future of sleep staging and scoring

C16

Sleep, fatigue and circadian rhythms in cancer patients

C17

Insomnia treatment, Part 1: Pharmacological treatments

C18

Multidimensional sleep health: From concept to clinic

COURSES | 1:00–5:00PM | PM HALF DAY C19

COURSES | 1:00–5:00PM | PM HALF DAY C09

Introduction to sleep and circadian health disparities

C10

Portable devices for clinical practice and sleep research

C11

Parasomnias

Sleep apnea and cancer

C20 Insomnia treatment, Part 2: Behavioral treatments C21

Narcolepsy and other hypersomnias: Diagnostics approach and management

C22 Sleep, psychiatric disorders & mental health

49 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

SAT

MARCH 12

SUN

MON

MARCH 13

TUES

MARCH 14

MARCH 15

WED

MARCH 16

Ticketed Events Ticket required to attend

Separately purchased ticket is required for entry to congress courses. Available at worldsleepcongress.com/register

C01: ART HISTORY AND HUMANITIES IN SLEEP: MORNING COURSE AND WALKING TOUR OF MUSEUM Coffee break 12:00pm – 12:45pm Narcolepsy in cinema Julie Flygare (United States)

10:00am – 2:00pm | Room 31 Chairs: Sonia Ancoli-Israel (United States); Meir Kryger (United States) 10:00am – 10:10am Introduction Sonia Ancoli-Israel (United States); Meir Kryger (United States)

12:45pm – 1:30pm Sleep in sound Milton Mermikides (United Kingdom); Debra J. Skene (United Kingdom)

10:10am – 10:55am Sleep in art and literature Meir Kryger (United States)

1:30pm – 2:00pm Question and answer Sonia Ancoli-Israel (United States); Meir Kryger (United States); Mario Fabiani (Italy)

10:55am – 11:40am Sleep in the bible Sonia Ancoli-Israel (United States) 11:40am – 12:00pm

REGISTER FOR COURSES

Ticketed Events Ticket required to attend

All courses require additional registration fees. Tickets for available sessions can be purchased at worldsleepcongress.com or onsite at the registration desk in Rome March 11-13, 2022.

COURSE FEES (HALF & FULL DAY) Type

EARLY

STANDARD

LATE /ON-SITE

February 1, 2021 – October 31, 2021

November 1, 2021 – January 31, 2022

February 1, 2022 – March 16, 2022

(US dollars)

(US dollars)

(US dollars)

Course (Full Day Delegate)

$165

$175

$195

Course (Half Day Delegate)

$110

$125

$140

Course (Full Day Technologist / Student)

$110

$125

$140

Course (Half Day Technologist / Student)

$80

$90

$115

50 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

Ticketed Events Ticket required to attend

C03: OBSTRUCTIVE SLEEP APNEA: DIAGNOSIS AND MANAGEMENT 8:00am – 5:00pm | Room 24 Chairs: Atul Malhotra (United States); Patrick Strollo (United States)

12:00pm – 1:00pm Lunch break

8:00am – 8:10am Introduction Patrick Strollo (United States), Atul Malhotra (United States) 8:10am – 8:30am Beyond the AHI: Revisiting metrics of SDB Atul Malhotra (United States)

9:15am – 9:40am Targeting endotypes/Phenotypes clinically Atul Malhotra (United States)

10:20am – 10:45am PAP outcomes Neomi Shah (United States) 10:45am – 11:05am Oral appliance update Olivier Vanderveken (Belgium) 11:05am – 11:30am Big data Jean-Louis Pepin (France)

1:20pm – 1:45pm UA surgical Olivier Vanderveken (Belgium)

2:05pm – 2:30pm OSA pharmacology Vsevolod Polotsky (United States)

8:50am – 9:15am OSA endotypes/Pathogenesis of OSA Andrey Zinchuk (United States)

10:00am – 10:20am PAP therapy Richard Schwab (United States)

1:00pm – 1:20pm UA surgery update medical Patrick Strollo (United States)

1:45pm – 2:05pm Alternatives / Complimentary Rx – UA Muscle Johan Verbraecken (Belgium)

8:30am – 8:50am Newer OSA metrics Scott Sands (United States)

9:40am – 10:00am Coffee break

11:30am – 12:00pm Question and answer Atul Malhotra (United States); Patrick Strollo (United States)

2:30pm – 2:50pm Coffee break 2:50pm – 3:05pm Successfully managing co-morbid disease: Insomnia and COPD Patrick Strollo (United States) 3:05pm – 3:20pm OSA and heart disease Reena Mehra (United States) 3:20pm – 3:35pm OSA and elderly Allan Pack (United States) 3:35pm – 3:55pm OSA care transformed by COVID Jennifer Newitt (United States) 3:55pm – 4:15pm OSA outcome measures Sanjay Patel (United States) 4:15pm – 5:00pm Question and answer Atul Malhotra (United States); Patrick Strollo (United States)

51 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

Ticketed Events Ticket required to attend C05: CIRCADIAN (DYS)FUNCTION IN HEALTH AND DISEASE 8:00am – 5:00pm | Room 13 Chairs: Sabra Abbott (United States); Till Roenneberg (Germany) 8:00am – 8:10am Introduction Sabra Abbott (United States); Till Roenneberg (Germany) 8:10am – 8:55am Neurobiology of circadian rhythms William Schwartz (United States) 8:55am – 9:40am The role of a healthy circadian clock in disease: The circadian clinic model Till Roenneberg (Germany); Sabra Abbott (United States) 9:40am – 10:00am Coffee break 10:00am – 10:45am Genetics, rest activity patterns and autism Maja Bucan (United States) 10:45am – 11:30am Circadian dysfunction in neurodegenerative disorders Christopher Colwell (United States) 11:30am – 12:00pm Open discussion / Q&A Sabra Abbott (United States) Till Roenneberg (Germany)

3:35pm – 4:20pm The impacts of Daylight Savings Time on health and disease Elizabeth Klerman (United States) 4:20 – 5:00 Question and answer Sabra Abbott (United States); Till Roenneberg (Germany)

C04: THE MYTHS AND SCIENCE OF DENTAL SLEEP MEDICINE 8:00am – 5:00pm | Room 14 Chairs: Fernanda Almeida (Canada); Maria Clotilde Carra (France) Morning session: Should Dental Sleep Medicine be an airway centered specialty?

8:00am – 8:15am Introduction Maria Clotilde Carra (France) 8:15am – 9:15am Decision criteria for the selection of OSA treatment Marc Braem (Belgium) 9:15am – 10:15am Improving oral appliance outcomes Francesca Milano (Italy)

12:00pm – 1:00pm Lunch break 1:00pm – 1:45pm Circadian rhythms in depression Sean Cain (Australia) 1:45pm – 2:30pm Impact of circadian rhythms on cardiovascular disease and recovery Tami Martino (Canada) 2:30pm – 2:50pm Coffee break

2:50pm – 3:35pm Circadian rhythms in the hospital setting Matthew Maas (United States)

10:15am – 10:35am Coffee break 10:35am – 11:35am Long-term benefits and consequences of oral appliances Ama Johal (United Kingdom) 11:35am – 12:35pm Interactions and treatment implications of OSA on periodontal diseases and tooth loss Maria Clotilde Carra (France)

52 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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12:35pm – 12:45pm Discussion panel

C07: RECENT ADVANCES IN RLS

12:45pm – 2:00pm Lunch break

8:00am – 12:00pm | Room 15 Chairs: Mauro Manconi (Switzerland); John Winkelman (United States)

TREATMENT

Afternoon session: Dealing with comorbidities: The role of dental professionals 2:00pm – 3:00pm Bruxism as a comorbidity: impact from diagnosis to treatment Frank Lobbezoo (Netherlands) 3:00pm – 4:00pm Clinical and imaging evaluation of the pediatric patient at high risk for OSA: The role of the dentist Carlos Flores-Mir (Canada) 4:00pm – 4:45pm Is the pediatric patient this complex?

Nelly Huynh (Canada) 4:45pm – 5:00pm Discussion about complex cases

8:00am – 8:10am Introduction Mauro Manconi (Switzerland) 8:10am – 8:50am Revision of standard guideline Michael Silber (United States) 8:50am – 9:20am Augmentation Claudia Trenkwalder (Germany) 9:20am – 9:50am Opioids John Winkelman (United States) 9:50am – 10:00am Coffee break 10:00am – 10:20am New drugs Diego Garcia-Borreguero (Spain) 10:20am – 10:40am Neuromodulation Mauro Manconi (Switzerland) 10:40am – 11:10am RLS in special conditions Lynn Marie Trotti (United States) 11:10am – 12:00pm Interactive cases discussion Mauro Manconi (Switzerland); Diego Garcia-Borreguero (Spain)

Ticketed Events Ticket required to attend 53 | Scientific Program | WORLD SLEEP 2022

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Ticketed Events Ticket required to attend C06: HOW TO CONDUCT EPIDEMIOLOGIC STUDIES OF SLEEP 8:00am – 12:00pm | Room 21 Chairs: Yue Leng (United States); Katie Stone (United States) 8:00am – 8:05am Introduction Yue Leng (United States); Katie Stone (United States) 8:05am – 8:45am Assessment of sleep in cohort studies Katie Stone (United States) 8:45am – 9:25am Introduction for epidemiology: Study design, confounding, bias Yue Leng (United States) 9:25am – 9:45am Coffee break 9:45am – 10:30am Search for causality in epidemiology: The case of sleep Francesco Cappuccio (United Kingdom) 10:30am – 11:15am “Sleep health” and machine learning approaches Meredith Wallace (United States) 11:15am – 12:00pm Genetics of sleep Richa Saxena (United States)

8:55am – 9:40am Circadian rhythm disorders Michael Gradisar (Australia) 9:40am – 10:00am Coffee break 10:00am – 10:45am Sleep disorder breathing: Prevalence and populations at risk Gustavo Moreira (Brazil) 10:45am – 11:30am Sleep disorder breathing: Consequences in children Albert Martin Li (Hong Kong) 11:30am – 12:05pm Question and answer 12:05pm – 1:05pm Lunch break 1:05pm – 1:50pm Update on sleep related movement disorders in children Daniel Picchietti (United States) 1:50pm – 2:35pm Evaluation of parasomnias in children Oliviero Bruni (Italy) 2:35pm – 2:55pm Coffee break 2:55pm – 3:40pm Sleep disorders in special pediatric populations Cathy Hill (United Kingdom)

C02: PEDIATRIC SLEEP 8:00am – 5:00pm | Room 22 Chairs: Lourdes DelRosso (United States); Gustavo Moreira (Brazil)

3:40pm – 4:25pm Practice of pediatric sleep around the world Judith Owens (United States) 4:25pm – 5:00pm Question and answer

8:00am – 8:10am Introduction 8:10am – 8:55am Insomnia Liat Tikotzky (Israel) 54 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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C08: PRESENT AND FUTURE OF SLEEP STAGING AND SCORING 8:00am – 12:00pm | Room 23 Chairs: Stephany Fulda (Switzerland); Ambra Stefani (Austria); Matteo Cesari (Austria) 8:00am – 8:10am Introduction Stephany Fulda (Switzerland); Ambra Stefani (Austria) 8:10am – 8:55am Sleep scoring: What can we do better?

Warren Ruehland (Australia) 8:55am – 9:25am Leg movement scoring: What do you need to know?

Stephany Fulda (Switzerland) 9:25am – 9:55am How to deal with REM sleep without atonia and video analysis for RBD diagnosis Ambra Stefani (Austria)

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ISRTP: WELCOME 8:00am – 9:00am | Room 33 Chair: Mike Mutschelknaus (United States)

ISRTP: WORLD SLEEP SOCIETY MISSION AND VISION 9:00am – 10:00am | Room 33 Chairs: Mike Mutschelknaus (United States); Birgit Högl (Austria); Phyllis Zee (United States)

ISRTP: RESEARCH DESIGN AND CASE STUDIES WORKSHOP 10:00am – 12:00pm | Room 33 Chairs: Mike Mutschelknaus (United States); Thomas Penzel (Germany); Danny Eckert (Australia); Joerg Steier (United Kingdom)

9:55am – 10:10am Coffee break 10:10am – 10:55am Digital sleep: Novel PSG metrics Diego Mazzotti (United States) 10:55am – 11:40am AI to advance sleep scoring: How to understand it?

Matteo Cesari (Austria) 11:40am – 12:00pm Question and answer Stephany Fulda (Switzerland); Ambra Stefani (Austria)

Ticketed Events Ticket required to attend 55 | Scientific Program | WORLD SLEEP 2022

COMMITTED TO ADVANCING BASIC & CLINICAL RESEARCH ON RLS

2 02

YEARS

0 -2 0 2 2

Celebrating JOIN US TO CELEBRATE OUR

20TH ANNIVERSARY SAVE THE DATE IRLSSG ANNUAL MEETING SUMMER 2022 Find more details and the latest updates at irlssg.org

MENTORING & TRAINING SLEEP RESEARCH LEADERS INTERNATIONAL SLEEP RESEARCH TRAINING PROGRAM

JOIN US FOR THE FOLLOWING DISCUSSION ON TUESDAY DS2: ISRTP MENTEES’ PERSPECTIVES ON OBSTRUCTIVE SLEEP APNEA THROUGHOUT THE WORLD 3:00pm – 4:30pm | Room 15 Chair: Arezu Najafi (Iran) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm Prevalence of obstructive sleep apnea in Iran: A population-based study Arezu Najafi (Iran)

STOCK PHOTO OF PENN

3:22pm – 3:42pm Relationships of atherosclerosis and OSA Soriul Kim (Korea, Republic of) 3:42pm – 4:02pm Leveraging genetic correlation between OSA traits and other trait to enhance genetic discovery and understanding of OSA Yuan Zhang (China) 4:02pm – 4:22pm The effect of armodafinil on sleep spindles in obstructive sleep apnea Leila Emami (Iran)

This educational initiative is supported by Philips.

4:22pm – 4:30pm Question and answer

WORLDSLEEPSOCIETY.ORG/ISRTP 57 | Scientific Program | WORLD SLEEP 2022

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Ticketed Events Ticket required to attend C10: PORTABLE DEVICES FOR CLINICAL PRACTICE AND SLEEP RESEARCH

C09: INTRODUCTION TO SLEEP AND

1:00pm – 5:00pm | Room 15 Chairs: Massimiliano de Zambotti (United States); Max Hirshkowitz (United States)

1:00pm – 5:00pm | Room 21 Chairs: Chandra Jackson (United States); Girardin Jean-Louis (United States)

1:00pm – 1:10pm Introduction Massimiliano de Zambotti (United States); Max Hirshkowitz (United States)

1:00pm – 1:05pm Introduction Chandra Jackson (United States)

1:10pm – 1:55pm How do we measure sleep? When a standard is the gold standard?

Max Hirshkowitz (United States) 1:55pm – 2:40pm Beyond motion: The nature and rational behind multisensor CST, and CST performance evaluation process Luca Menghini (Italy)

CIRCADIAN HEALTH DISPARITIES

1:05pm – 1:50pm Introduction to the multi-level determinants of sleep health disparities across the globe Chandra Jackson (United States) 1:50pm – 2:30pm Physical environments and sleep health disparities across the globe Dayna Johnson (United States) 2:30pm – 2:50pm Coffee break

2:40pm – 3:00pm Coffee break 3:00pm – 3:45pm CST landscape and performance in measuring sleep, Evaluation of Pros and Cons of CST and practical points Massimiliano de Zambotti (United States)

2:50pm – 3:30pm Social environment and sleep health disparities across the globe Michael Grandner (United States)

3:45pm – 4:30pm Not only sleep tracking: Application of CSTs for measuring sleep-related physiology Thomas Penzel (Germany)

3:30pm – 4:05pm Sleep and cardiovascular disease disparities among global populations burdened by disparities Mercedes Carnethon (United States)

4:30pm – 5:00pm Question and answer

4:05pm – 4:50pm Transformational stakeholder engagement: A model to improve sleep/circadian health in vulnerable communities Girardin Jean-Louis (United States) 4:50pm – 5:00pm Question and answer

Ticketed Events Ticket required to attend 58 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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C11: PARASOMNIAS 1:00pm – 5:00pm | Room 23 Chairs: Federica Provini (Italy); Isabelle Arnulf (France) 1:00pm – 1:10pm Introduction Federica Provini (Italy); Isabelle Arnulf (France) 1:10pm – 1:55pm DOA across the lifespan and how to distinguish from nocturnal seizures Federica Provini (Italy) 1:55pm – 2:40pm Sleep related eating disorder and its differential diagnosis Yuichi Inoue (Japan) 2:40pm – 3:00pm Coffee break 3:00pm – 3:45pm Dreaming and dream disorders across NREM and REM sleep Isabelle Arnulf (France) 3:45pm – 4:30pm Causes of sleep violence and update on RBD and parasomnia overlap disorder Carlos Schenck (United States) 4:30pm – 5:00pm Question and answer Federica Provini (Italy); Isabelle Arnulf (France)

Ticketed Events Ticket required to attend 59 | Scientific Program | WORLD SLEEP 2022

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Ticketed Events Ticket required to attend C13: YEAR IN REVIEW 8:00am – 5:00pm | Room 11 Chairs: Winfried Randerath (Germany); Dieter Riemann (Germany) 8:00am – 8:05am Introduction Dieter Riemann (Germany) 8:05am – 8:50am Sleep and emotion regulation Chiara Baglioni (Italy and Germany) 8:50am – 9:35am Narcolepsy Yves Dauvilliers (France)

3:00pm – 3:45pm Sleep and epilepsy Birgit Frauscher (Canada) 3:45pm – 4:30pm Women’s sleep Laura Palagini (Italy) 4:30pm – 5:00pm Question and answer Dieter Riemann (Germany)

C12: SLEEP HEALTH IN WOMEN 8:00am – 5:00pm | Room 13 Chair: Maree Barnes (Australia); Sara Nowakowski (United States)

9:35am – 9:55am Coffee break

8:00am – 8:10am Welcome Sara Nowakowski (United States)

9:55am – 10:40am Insomnia mechanisms Kai Spiegelhalder (Germany) 10:40am – 11:25am Cognitive behavioral therapeutics for insomnia Colin Espie (United Kingdom) 11:25am – 12:10pm Novel psychotherapeutic approaches for insomnia Elisabeth Hertenstein (Switzerland) 12:10pm – 1:10pm Lunch break 1:10pm – 1:55pm Sleep and psychiatry Christoph Nissen (Switzerland)

8:10am – 8:55am Sex differences in adolescent sleep Mary Carskadon (United States); Darlynn Rojo-Wisser (United States) 8:55am – 9:40am The relationship between the menstrual cycle and sleep Fiona Baker (United States) 9:40am – 10:25am Sex differences in upper airway physiology: Implications for OSA pathophysiology and treatment Danny Eckert (Australia) 10:25am – 10:45am Coffee break

1:55pm – 2:40pm Sleep-related breathing disorders Winfried Randerath (Germany)

10:45am – 11:30am Normal sleep and CBT-i in pregnancy Anna L. Mackinnon (Canada)

2:40pm – 3:00pm Coffee break

11:30am – 12:15pm SDB in Pregnancy Riva Tauman (Israel) 60 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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12:15pm – 12:30pm Open discussion Maree Barnes (Australia); Sara Nowakowski (United States)

9:03 – 9:56 Sleep disordered breathing and neurodegeneration Claudio Liguori (Italy)

12:30pm – 1:15pm Lunch break

9:56am – 10:16am Coffee break

1:15pm – 2:00pm Women, circadian rhythms and shift work Katherine Sharkey (United States)

10:16am – 11:09am Sleep dysfunction in movement disorders Federica Provini (Italy)

2:00pm – 2:45pm Sleep and mental health in women Laura Palagini (Italy)

11:09am – 12:02pm Circadian biology of movement disorders Aleksandar Videnovic (United States)

2:45pm – 3:00pm Coffee break

12:02pm – 1:02pm Lunch break

3:00pm – 3:45pm Sleep disturbance in natural menopause vs. surgical menopause Sara Nowakowski (United States)

1:02pm – 1:55pm Sleep, clocks, and alzheimer’s disease Bryce Mander (United States)

3:45pm – 4:30pm Sleep in the post-menopausal woman Helena Hachul (Brazil) 4:30pm – 5:00pm Question and answer Sara Nowakowski (United States); Maree Barnes (Australia)

C14: AGING, NEURODEGENERATION AND SLEEP 8:00am – 5:00pm | Room 14 Chairs: Claudio Liguori (Italy); Aleksandar Videnovic (United States) 8:00am – 8:10am Introduction Claudio Liguori (Italy); Aleksandar Videnovic (United States)

1:55pm – 2:48pm What animal models teach us about sleep and neurodegeneration Oliver Rawashdeh (Australia) 2:48pm – 3:08pm Coffee break 3:08pm – 4:01pm REM sleep behavior disorder: A disorder on the intersection of neurology, neuroscience and sleep medicine Ambra Stefani (Austria) 4:01pm – 5:00pm Case studies of sleep and circadian disorders associated with neurodegeneration Claudio Liguori (Italy); Aleksandar Videnovic (United States); Bryce Mander (United States); Oliver Rawashdeh (Australia); Ambra Stefani (Austria); Federica Provini (Italy)

8:10am – 9:03am Sleep and circadian rhythms in healthy aging Biancamaria Guarnieri (Italy) 61 | Scientific Program | WORLD SLEEP 2022

Ticketed Events Ticket required to attend

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Ticketed Events Ticket required to attend C15: CARDIOVASCULAR CONSEQUENCES OF SLEEP APNEA: WHAT IS NEW? 8:00am – 5:00pm | Room 15 Chairs: Manuel Sánchez de la Torre (Spain) Virend Somers (United States) 8:00am – 8:10am Welcome and introduction Manuel Sánchez de la Torre (Spain); Virend Somers (United States) 8:10am – 8:55am OSA and CV disease: Significant findings and emerging questions from the last 3 years Ferran Barbe (Spain) 8:55am – 9:40am OSA beyond adults! What we have learned from the cardiovascular impact of OSA in Children?

Raouf Amin (United States) 9:40am – 10:00am Coffee break 10:00am – 10:45am OSA and hypertension: Is the game over or are there new paths to follow?

Martino Pengo (Italy) 10:45am – 11:30am The impact of OSA on metabolic syndrome and diabetes: Myth or reality?

Luciano Drager (Brazil) 11:30am – 12:00pm Question and answer

2:30pm – 2:50pm Coffee break 2:50pm – 3:35pm Why haven’t treatment trials in OSA shown cardiovascular benefits?

Shahrokh Javaheri (United States) 3:35pm – 4:20pm Cardiovascular RCTs in OSA: What is new?

Doug Bradley (Canada) 4:20pm – 5:00pm Question and answer

C16: SLEEP, FATIGUE AND CIRCADIAN RHYTHMS IN CANCER PATIENTS 8:00am–12:00pm | Room 21 Chairs: Josee Savard (Canada); Lisa Wu (Denmark) 8:00am – 8:10am Introduction Lisa Wu (Denmark) 8:10am – 8:50am Introduction to sleep, fatigue and circadian rhythms in cancer Sonia Ancoli-Israel (United States) 8:50am – 9:30am Systematic light exposure for the treatment of sleep disturbance and fatigue in cancer Lisa Wu (Denmark) 9:30am – 9:50am Coffee break

12:00pm – 1:00pm Lunch break 1:00pm – 1:45pm It’s not just the AHI: Sleepiness as a risk factor in OSA Naima Covassin (United States) 1:45pm – 2:30pm It’s not just the AHI: The impact of hypoxemic burden on CV events Ali Azarbazin (United States)

9:50am – 10:30am Internet-delivered cognitive-behavioral therapy for insomnia in breast cancer survivors Ali Amidi (Denmark) 10:30am – 11:10am The implementation of cognitive behavioral therapy for insomnia in routine cancer care Josee Savard (Canada)

62 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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11:10am – 11:45am Implementation and adaptation to cancer populations: Case study activity Josee Savard (Canada); Lisa Wu (Denmark); Ali Amidi (Denmark); Sonia Ancoli-Israel (United States) 11:45am – 12:00pm Question and answer Lisa Wu (Denmark)

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C18: MULTIDIMENSIONAL SLEEP HEALTH FROM CONCEPT TO CLINIC 8:00am – 12:00pm | Room 23 Chairs: Bjørn Bjorvatn (Norway); Daniel J. Buysse (United States) 8:00am – 8:05am Introduction

PHARMACOLOGICAL TREATMENTS

8:05am – 8:50am Sleep health: From concept to clinic Daniel J. Buysse (United States)

8:00am – 12:00pm | Room 22 Chairs: David Neubauer (United States); Gary Zammit (United States)

8:50am – 9:35am Measurement tools for multidimensional sleep health Pierre Philip (France)

8:00am – 8:10am Introduction David Neubauer (United States)

9:35am – 9:55am Coffee break

8:10am – 8:55am Overview of insomnia medications David Neubauer (United States)

9:55am – 10:40am Analytic approaches for multidimensional sleep health: From the simple to the sublime Meredith Wallace (United States)

8:55am – 9:40am Study designs for clinical trials of sleep promoting drugs Gary Zammit (United States)

10:40am – 11:25am In the clinic: Novel interventions based on sleep health Kelly Baron (United States); Wendy Troxel (United States)

9:40am – 10:00am Coffee break

11:25am – 12:00pm Question and answer

C17: INSOMNIA TREATMENT, PART 1:

10:00am – 10:45am Therapeutic and safety outcomes in insomnia trials Thomas Roth (United States) 10:45am – 11:30am Abuse liability of medications used for insomnia Sandra Comer (United States) 11:30am – 12:00pm Question and answer

Ticketed Events Ticket required to attend 63 | Scientific Program | WORLD SLEEP 2022

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Ticketed Events Ticket required to attend ISRTP: GRANT BUDGETS 8:00am - 9:00am | Room 33 Chairs: Mike Mutschelknaus (United States); Diane Lim (United States)

ISSTA: SLEEP SCIENCE, TECHNOLOGY AND ECONOMY SYMPOSIUM

2:25pm – 3:15pm Intermittent hypoxia and cancer: Lessons from cellular and animal models Isaac Almendros (Spain) 3:15pm – 4:05pm Sleep apnea and cancer: Scandalous bedtime stories David Gozal (United States) 4:05pm – 5:00pm Question and answer

9:00am - 4:00pm | Room 31 Chair: Rayleigh Chiang (Taiwan)

ISRTP: INDUSTRY GRANTS WORKSHOP 9:00am - 10:30am | Room 33 Chair: Mike Mutschelknaus (United States)

ISRTP: EXPLORING COLLABORATIVE INTERNATIONAL GRANT OPPORTUNITIES 10:30am - 12:00pm | Room 33 Chairs: Mike Mutschelknaus (United States); Bingqian Zhu (China); Simon Kyle (United Kingdom)

C19: SLEEP APNEA AND CANCER 1:00pm – 5:00pm | Room 21 Chairs: Isaac Almendros (Spain); David Gozal (United States) 1:00pm – 1:15pm Introduction David Gozal (United States); Isaac Almendros (Spain) 1:15pm – 2:05pm Circadian and sleep aspects of cancer Maria Paola Mogavero (Italy) 2:05pm – 2:25pm Coffee break

C20: INSOMNIA TREATMENT, PART 2: BEHAVIORAL TREATMENTS 1:00pm – 5:00pm | Room 22 Chairs: Colleen Carney (Canada); Jason Ellis (United Kingdom) 1:00pm – 1:10pm Introduction Colleen Carney (Canada); Jason Ellis (United Kingdom) 1:10pm – 1:55pm Overview of CBT-I Ellemarije Altena (France) 1:55pm – 2:40pm Innovations in CBT-I Research Jason Ellis (United Kingdom) 2:40pm – 3:00pm Coffee break 3:00pm – 3:45pm Case Formulation Approach to CBT-I Colleen Carney (Canada) 3:45pm – 4:30pm Innovations in CBT-I practice Leon Lack (Australia) 4:30pm – 5:00pm Panel discussion Colleen Carney (Canada); Jason Ellis (United Kingdom)

64 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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C21: NARCOLEPSY AND OTHER

C22: SLEEP, PSYCHIATRIC DISORDERS &

HYPERSOMNIAS: DIAGNOSTIC APPROACH AND MANAGEMENT

MENTAL HEALTH

1:00pm – 5:00pm | Room 23 Chairs: Yves Dauvilliers (France); Fabio Pizza (Italy) 1:00pm – 1:10pm Introduction Yves Dauvilliers (France) 1:10pm – 1:45pm Excessive Daytime Sleepiness: Current diagnostic nosography of central disorders of hypersomnolence Michael Thorpy (United States) 1:45pm – 2:15pm Neurophysiological assessment of central disorders of hypersomnolence: Pitfalls and future perspectives Fabio Pizza (Italy) 2:15pm – 2:30pm Coffee break 2:30pm – 3:05pm Narcolepsy and other hypersomnolence disorders in children: State of the art Kiran Maski (United States) 3:05pm – 3:40pm Pharmacological management of narcolepsy: Current guidelines Lucie Barateau (France) 3:40pm – 4:15pm Metabolic and psychiatric comorbidities in narcolepsy at different ages Giuseppe Plazzi (Italy) 4:15pm – 4:45pm Perspectives in the management of central hypersomnolence disorders Yves Dauvilliers (France)

1:00pm – 5:00pm | Room 24 Chair: Chiara Baglioni (Italy and Germany) 1:00pm – 1:10pm Introduction Chiara Baglioni (Italy and Germany) 1:10pm – 1:55pm Sleep continuity as a predictor of mental disorders in adults Chiara Baglioni (Italy and Germany) 1:55pm – 2:40pm Circadian rhythm disruption in mental disorders Katharina Wulff (Sweden) 2:40pm – 3:00pm Coffee break 3:00pm – 3:45pm Sleep disruption in childhood and adolescence and its relationship with affective disturbances Candice A. Alfano (United States) 3:45pm – 4:30pm Sleep EEG in insomnia and mental disorders and the effects of sleep treatment on outcomes Ruth Benca (United States) 4:30pm – 5:00pm Question and answer Chiara Baglioni (Italy and Germany)

SOCIAL EVENT: OPENING CEREMONY 6:30pm – 8:00pm | Roma Convention Center La Nuvola Auditorium

4:45pm – 5:00pm Question and answer

Ticketed Events Ticket required to attend 65 | Scientific Program | WORLD SLEEP 2022

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K01 | PHYLLIS ZEE: CIRCADIAN CLOCKS: MEDICINE IN THE FOURTH DIMENSION 8:00am – 8:45am | Room 11

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10:02am – 10:22am A longitudinal global perspective on next steps Kyla Wahlstrom (United States) 10:22am – 10:30am Question and answer

8:00am – 8:02am Introduction Till Roenneberg (Germany)

S02: PRECISION MEDICINE FOR RESTLESS LEGS

8:02am – 8:45am Keynote Presentation Phyllis Zee (United States)

SYNDROME: FROM TRIAL-AND-ERROR TO ACCURATE PREDICTION

K02 | GIUSEPPE PLAZZI: PEDIATRIC NARCOLEPSY: CLINICAL FEATURES AND BURDEN OF ILLNESS 8:00am – 8:45am | Room 24

9:00am – 10:30am | Room 13 Chair: Juliane Winkelmann (Germany) 9:00am – 9:02am Introduction 9:02am – 9:22am Epidemiological predictors of RLS susceptibility Klaus Berger (Germany)

8:00am – 8:02am Introduction Raffaele Ferri (Italy)

9:22am – 9:42am Genetic risk scores as predictors of RLS susceptibility and phenotype Barbara Schormair (Germany)

8:02am – 8:45am Keynote Presentation Giuseppe Plazzi (Italy)

S01: A GLOBAL PERSPECTIVE ON SCHOOL START TIMES: HOW FAR WE’VE COME AND WHERE WE GO FROM HERE 9:00am – 10:30am | Room 11 Chair: Judith Owens (United States) 9:00am – 9:02am Introduction 9:02am – 9:22am Beyond adolescent sleep: A systemic perspective on the ripple effect of changing secondary school start times Lisa Meltzer (United States) 9:22am – 9:42am Challenges in the Middle East Saadoun Bin-Hasan (Kuwait) 9:42am – 10:02am Sleep educational intervention in UK high schools: The ‘Teensleep’ programme Colin Espie (United Kingdom)

9:42am – 10:02am Predictors of dopaminergic augmentation Evi Holzknecht (Austria) 10:02am – 10:22am Predictors of treatment response, dose stability and tolerability of opioids: data from the National RLS opioid registry John Winkelman (United States) 10:22am – 10:30am Question and answer

S03: SLEEP, EMOTIONS AND MENTAL HEALTH DURING THE COVID 19 PANDEMIC ACROSS COUNTRIES AND POPULATIONS: FOCUS ON WOMEN’S HEALTH 9:00am – 10:30am | Room 14 Chair: Rodolfo Rossi (Italy) 9:00am – 9:02am Introduction

66 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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9:02am – 9:18am Sleep, Emotions and Mental Health during the COVID 19 Pandemic Veronica Guadagni (Canada)

9:50am – 10:06am International COVID Sleep Study (ICOSS): Large differences in sleep problems between countries Bjørn Bjorvatn (Norway)

9:18am – 9:34am Sleeping for two: Preliminary RCT findings of CBT for insomnia during pregnancy Anna L. Mackinnon (Canada)

10:06am – 10:22am Sleep disturbances as mediators in the association between COVID-19 related stressors and psychological distress among adolescents in Israel Dorit Hadar Souval (Israel)

9:34am – 9:50am Links between prenatal distress, infant brain structure and function, and infant sleep patterns Claire Donnici (Canada) 9:50am – 10:06am Sleep disturbances and stress-related disorders in healthcare workers during the COVID-19 pandemic in Italy Rodolfo Rossi (Italy) 10:06am – 10:22am The global impact of COVID19 and social distancing on sleep, stress, and mood Tony Cunningham (United States) 10:22am – 10:30am Question and answer

S04: INTERNATIONAL AND CULTURAL PERSPECTIVES ON COVID-19 STRESS, SLEEP, AND EMOTIONAL WELL BEING (AMONG ADOLESCENTS AND ADULTS) 9:00am – 10:30am | Room 15 Chair: Orna Tzischinsky (Israel) 9:00am – 9:02am Introduction 9:02am – 9:18am Sleep quality and mental health during COVID-19: Comparison between Israel and United States Orna Tzischinsky (Israel) 9:18am – 9:34am The effect of remote work on psychosomatic symptoms, sleep, and rhythms Akiyoshi Shimura (Japan) 9:34am – 9:50am Sleeping during COVID-19 restrictions: The Italian case Nicola Cellini (Italy)

10:22am – 10:30am Question and answer

S05: SLEEP SURGERY: FROM PAST, PRESENT, TO PRECISION 9:00am – 10:30am | Room 21 Chair: Stanley Liu (United States) 9:00am – 9:02am Introduction 9:02am – 9:18am Application of drug-induced sleep endoscopy in surgical patient selection Marina Carrasco (Spain) 9:18am – 9:34am Precision in transoral robotic surgery Claudio Vicini (Italy) 9:34am – 9:50am Hypoglossal nerve stimulation - Where do we go from here Clemens Heiser (Germany) 9:50am – 10:06am How does maxillary expansion and MMA impact other interventions for OSA Stanley Liu (United States) 10:06am – 10:22am Adapting the SAMS clinical trial to other sleep surgical procedures Stuart Mackay (Australia) 10:22am – 10:30am Question and answer

67 | Scientific Program | WORLD SLEEP 2022

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S06: THE IMMUNE PATHOGENESIS OF NARCOLEPSY TYPE 1 – RECENT INSIGHTS AND FUTURE DIRECTIONS 9:00am – 10:30am | Room 22 Chair: Rolf Fronczek (Netherlands)

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9:22am – 9:42am High density EEG analysis and cyclic alternating pattern analysis in children with ADHD Silvia Miano (Switzerland)

9:00am – 9:02am Introduction

9:42am – 10:02am A longitudinal assessment of NREM sleep EEG in typically developing and medication-free ADHD adolescents Nato Darchia (Georgia)

9:02am – 9:18am Autoimmunity in narcolepsy - an overview of the literature Daniela Latorre (Italy)

10:02am – 10:22am Cognitive dysfunction in self-limited focal epilepsies of childhood Alexander N Datta (Switzerland)

9:18am – 9:34am Hypothalamic changes following H1N1 infection or vaccination Birgitte Kornum (Denmark)

10:22am – 10:30am Question and answer

9:34am – 9:50am Immunological and clinical findings in post-H1N1 narcolepsy Stine Knudsen-Heier (Norway) 9:50am – 10:06am Post-mortem data and future directions Mink Schinkelshoek (Netherlands) 10:06am – 10:14am Question and answer

S07: THE DEVELOPING BRAIN AND SLEEP: WHAT DO WE KNOW? THE MODEL OF ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) 9:00am – 10:30am | Room 23 Chair: Silvia Miano (Switzerland) 9:00am – 9:02am Introduction 9:02am – 9:22am An update on sleep problems and management challenges in ADHD Reut Gruber (Canada)

S08: SLEEP REVOLUTION – NOVEL DIAGNOSTIC METHODS FOR OSA 9:00am – 10:30am | Room 24 Chairs: Erna Sif Arnardóttir (Iceland); Walter McNicholas (Ireland) 9:00am – 9:02am Introduction 9:02am – 9:22am Beyond the AHI - a multi-component of OSA classification (Baveno) Winfried Randerath (Germany) 9:22am – 9:42am Patient-reported outcomes: The new mainstay for assessing severity and therapeutic results in OSA? Dirk Pevernagie (Belgium) 9:42am – 10:02am Beyond the AHI: Alternative diagnostic parameters and machine learning solutions for estimation of the severity of OSA Timo Leppänen (Finland) 10:02am – 10:22am Upper airways obstruction and snoring Erna Sif Arnardóttir (Iceland) 10:22am – 10:30am Question and answer

68 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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O01: SLEEP DISORDERED BREATHING: CARDIOVASCULAR ASSOCIATIONS AND CONSEQUENCES 9:00am – 10:30am | Room 31 9:00am – 9:13am Heart rate response to apneas and hypopneas predicts incident atrial fibrillation in sleep apnea Gonzalo Labarca (United States) 9:13am – 9:26am Arterial bicarbonate is associated with hypoxic burden and hypertension in obstructive sleep apnea - the ESADA cohort Ding Zou (Sweden) 9:26am – 9:39am Independent predictors of long-term mortality of patients with moderate to severe sleep with reduced left ventricular ejection fraction after myocardial infarction Ondrej Ludka (Czech Republic)

O02: SLEEP HEALTH AND SOCIAL DISPARITIES 9:00am – 10:30am | Room 32 9:00am – 9:15am Effects of air pollution exposure predicting sleep efficiency in children modified by exposure to violence, 4-7 years, in the PROGRESS birth cohort.

Terry Thompson (United States) 9:15am – 9:30am Who Sleeps Well in Canada? Social Determinants of Sleep Health Disparities Among Middle-Aged and Older Adults in the Canadian Longitudinal Study on Aging Saverio Stranges (Canada) 9:30am – 9:45am Impact of Neighborhood and Environmental Factors on Sleep Health Among Middle-Aged and Older Adults in the Canadian Longitudinal Study on Aging Saverio Stranges (Canada)

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9:45am – 10:00am Sleep and the Menstrual Cycle: A Review of 48,720 Cycles Nina Thigpen (United States) 10:00am – 10:15am Examination of prospective sleep across the menstrual cycle Sara Nowakowski (United States)

O03: CIRCADIAN DISORDERS GENETICS AND HEALTH RISKS 9:00am – 10:30am | Room 33 9:00am – 9:13am Enrichment of the VNTR PER3 variant in DSWPD patients: A large whole genome sequencing analysis Jennifer Brzezynski (United States) 9:13am – 9:26am An observational study to investigate CRY1 variants associated with familial delayed sleep-wake patterns Sandra Smieszek (United States) 9:26am – 9:39am The impact of obstructive sleep apnea treatment with continuous positive airway pressure on the biological clock Ana Rita Alvaro (Portugal) 9:39am – 9:52am Clock genes expression and other sleep-wake rhythm biomarkers profiles among acute ischemic stroke patients Evelina Pajediene (Lithuania) 9:52am – 10:05am Multi-tissue Disruption of Molecular Circadian Rhythms After Intensive Care Ron C. Anafi (United States) 10:05am – 10:18am Seasonal variations in objective sleep duration and quality: A longitudinal big-data analysis Luke Gahan (Ireland)

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EXHIBIT HALL 9:30am – 4:00pm | Exhibit Hall

S09: HYPERSOMNOLENCE AND HYPERSOMNIA: WHERE DO WE STAND? 10:45am – 12:15pm | Room 13 Chair: Maurice M. Ohayon (United States) 10:45am – 10:47am Introduction 10:47am – 11:07am Epidemiology of hypersomnolence disorders Maurice M. Ohayon (United States) 11:07am – 11:27am Excessive daytime sleepiness: Beyond the Epworth Sleepiness Scale – results from a population-based study Dalva Poyares (Brazil) 11:27am – 11:47am The burden of hypersomnolence disorders: Results from a German cohort Ulf Kallweit (Germany)

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11:07am – 11:27am Insomnia and emotion regulation - a study with ecologocal momentary assessment Chiara Baglioni (Italy and Germany) 11:27am – 11:47am Insomnia affects brain network connectivity when watching humorous films Ernesto Sanz-Arigita (France) 11:47am – 12:07pm Altered perception of sleep in insomnia - the role of REM sleep instability Bernd Feige (Germany) 12:07pm – 12:15pm Question and answer

S11: GENETICS OF OBSTRUCTIVE SLEEP APNEA 10:45am – 12:15pm | Room 15 Chair: Allan I Pack (United States) 10:45am – 10:47am Introduction

11:47am – 12:07pm Usefulness and limits of existing treatments for hypersomnolence disorders Yves Dauvilliers (France)

10:47am – 11:07am What do we know about the genetics of OSA? Where are we going?

Brian Cade (United States)

12:07pm – 12:15pm Question and answer

11:07am – 11:27am Genetic analysis of obstructive sleep apnea discovers a strong association with cardiometabolic health Martin Broberg (Finland)

S10: CHRONIC INSOMNIA: THE ROLE OF EMOTION REGULATION AND REM SLEEP 10:45am – 12:15pm | Room 14 Chairs: Chiara Baglioni (Italy and Germany); Ellemarije Altena (France) 10:45am – 10:47am Introduction 10:47am – 11:07am Psychoneurobiology of insomnia - an overview Eus van Someren (Netherlands)

11:27am – 11:47 Using large biobanks to investigate the genetics of OSA Anne Justice (United States) 11:47am – 12:07pm Genetics of craniofacial structure: Ethnic differences Soriul Kim (Korea, Republic of) 12:07pm – 12:15pm Question and answer

70 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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S12: TARGETED USE OF DRUG INDUCED SLEEP ENDOSCOPY (DISE) COMBINED WITH MACHINE LEARNING ADVANCES IN ULTRASOUND, SNORING SOUND, AND COMPUTATIONAL FLUID DYNAMICS 10:45am – 12:15pm | Room 21 Chair: Stanley Liu (United States); Nico de Vries (Netherlands) 10:45am – 10:47am Introduction 10:47am – 11:03am Airway collapse patterns visualized with DISE: Latest updates from surgery Marina Carrasco (Spain) 11:03am – 11:19am Maneuvers and oral appliance testing during DISE Pien Bosschieter (Netherlands) 11:19am – 11:35am Using DISE and snoring sound with machine learning algorithms to predict airway collapse patterns in OSA Sophia Ying-Chieh Hsu (United States) 11:35am – 11:51am Computational fluid dynamics modeling correlated with DISE for prediction of airway collapse Guilherme Garcia (Brazil) 11:51am – 12:07pm Correlating airway ultrasound with machine learning algorithms and DISE to predict airway collapse patterns in OSA Stanley Liu (United States)

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10:47am – 11:03am Assessing sleep in pediatric sleep intervention trials: What are the pros and cons of prioritizing subjective or objective measures?

Stephen Becker (United States) 11:03am – 11:19am Concordance across sleep measures and variables in typically developing children and children with neurodevelopmental disorders Penny Corkum (Canada) 11:19am – 11:35am Integrating sleep into care for children with cerebral palsy through a 24-hour activity approach Raquel Hulst (Netherlands) 11:35am – 11:51am Sleep in neurodevelopmental disorders: Causes and contributors and relevance to sleep measurement Beth Malow (United States) 11:51am – 12:07pm Measuring sleep behaviour in school-based sleep education programs: Is sleep duration the best outcome variable?

Gabrielle Rigney (Australia) 12:07pm – 12:15pm Question and answer

S14: OBSTRUCTIVE SLEEP APNEA AND ORODENTAL COMORBIDITIES: HOW TO NAVIGATE IN DIAGNOSIS AND MANAGEMENT 10:45am – 12:15pm | Room 23 Chair: Frank Lobbezoo (Netherlands)

12:07pm – 12:15pm Question and answer

10:45am – 10:47am Introduction

S13: ARE OBJECTIVE MEASURES ALWAYS

10:47am – 11:03am Obstructive sleep apnea and sleep bruxism Ghizlane Aarab (Netherlands)

NEEDED? MEASURING OUTCOMES IN CLINICAL TRIALS EVALUATING PEDIATRIC SLEEP INTERVENTIONS 10:45am – 12:15pm | Room 22 Chair: Shelly Weiss (Canada)

11:03am – 11:19am Obstructive sleep apnea and orofacial pain Gilles Lavigne (Canada)

10:45am – 10:47am Introduction 71 | Scientific Program | WORLD SLEEP 2022

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11:19am – 11:35am Obstructive sleep apnea and oral moistening disorders Frank Lobbezoo (Netherlands)

O04: INSOMNIA AND TREATMENT

11:35am – 11:51am Obstructive sleep apnea and gastro-esophageal reflux Daniele Manfredini (Italy)

10:45am – 11:00am The effects of Cognitive Behaviour Therapy for insomnia and Continuous Positive Airway Pressure on neurocognitive functioning in individuals with comorbid insomnia and sleep apnea (COMISA) Matthew Salanitro (Germany)

11:51am – 12:07pm Bridging medical and dental expertise in sleep medicine Peter Cistulli (Australia) 12:07pm – 12:15pm Question and answer

S15: SLEEP REVOLUTION - TELEMEDICINE IN SLEEP RESEARCH 10:45am – 12:15pm | Room 24 Chairs: Timo Leppänen (Finland); Thomas Penzel (Germany) 10:45am – 10:47am Introduction 10:47am – 11:03am Platformization in healthcare: Co-designing a digital platform for improved sleep analysis Anna Sigríður Islind (Iceland) 11:03am – 11:19am Objective measures of cognitive performance in sleep disorder research: A brief overview and future perspectives Kamilla Rún Jóhannsdóttir (Iceland) 11:19am – 11:35am Self-applied polysomnography - a real possibility?

Erna Sif Arnardóttir (Iceland)

10:45am – 12:15pm | Room 31

11:00am – 11:15am A virtual reality mind-body approach targeting hyperarousal in adolescents with insomnia: new directions for treatment Massimiliano de Zambotti (United States) 11:15am – 11:30am Digital Cognitive Behavioral Therapy for Insomnia Promotes Resilience During the Coronavirus Disease 19 (COVID-19) Pandemic Philip Cheng (United States) 11:30am – 11:45am Long-term safety and efficacy of daridorexant in patients with insomnia disorder Dieter Kunz (Germany)

O05: DEVELOPMENTAL ISSUES IN PEDIATRIC SLEEP 10:45am – 12:15pm | Room 32 10:45am – 11:00am Prevalence, patterns and socio-demographic correlates of sleep duration in adolescents: Results from the labmed study Eduarda Sousa-Sá (Portugal)

11:35am – 11:51am Understanding sleep through wearable devices María Óskarsdóttir (Iceland) 11:51am – 12:07pm Minimal-contact methods in respiratory medicine Christoph Schöbel (Germany) 12:07pm – 12:15pm Question and answer 72 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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11:00am – 11:15am Sleep versus school timings of preschool and school-age children Maria Inês Clara (Portugal) 11:15am – 11:30am Cortical hemodynamic changes associated with sleep slow waves in school-age children Damiana Bergamo (Italy) 11:30am – 11:45am Lessons from the COVID-19 Shutdown: the Waitlist Challenge & Insights in Overmedication Pathways Osman Ipsiroglu (Canada) 11:45am – 12:00pm Infant Sleep as a Marker of Neurodevelopment Soraia Ventura (Ireland)

O06: TECHNOLOGIES, METHODS, PHARMACOLOGY 10:45am – 12:15pm | Room 33 10:45am – 11:00am Evaluating the Impact of Social Media Usage and Blue Light on Pre-Sleep Arousal and Sleep among Young Women Maren-Jo Kater (Germany) 11:00am – 11:15am Somnologics - Medicines for the Treatment of Sleep Disorders Sebastian Herberger (Germany)

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JAZZ PHARMACEUTICALS: EXCESSIVE DAYTIME SLEEPINESS (EDS) IN OSA – A COMPLEX AND CHALLENGING REALITY 12:30pm – 2:00pm | Room 11 Chair: Luigi Ferini-Strambi (Italy) 12:30pm – 12:35pm Welcome Luigi Ferini-Strambi (Italy) 12:33pm – 12:53pm A spotlight on EDS in OSA – patient insights Luigi Ferini-Strambi (Italy); Birgit Högl (Austria) 12:53pm – 1:13pm Navigating the complexities of EDS The EDS journey – it’s personal!

Alanna Hare (United Kingdom); Elizabeth Hill (United Kingdom) 1:13pm – 1:23pm Panel discussion 1:23pm – 1:38pm Therapeutic advances – reawakening our patients Eline Gantzhorn (Denmark); Simon Herkenrath (Germany) 1:38pm – 1:58pm Panel discussion 1:58pm – 2:00pm Close Luigi Ferini-Strambi (Italy)

11:15am – 11:30am Night-to-Night Variability of Sleep Quality using Odds Ratio Product: An Assessment of 14-31 Nights of In-Home Polysomnography Amy Bender (Canada) 11:30am – 11:45am Selective slow-wave sleep suppression through auditory closed-loop stimulation Kristoffer Daniel Fehér (Switzerland) 11:45am – 12:00pm Manual versus computer-aided scoring of sleep studies: preliminary results on inter-rater agreement and analysis of scoring time differences in one sleep center Diego Alvarez-Estevez (Netherlands) 73 | Scientific Program | WORLD SLEEP 2022

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SLEEP NUMBER: CAN THE SLEEPING ENVIRONMENT BE OPTIMIZED TO IMPROVE SLEEP QUALITY? 12:30pm – 2:00pm | Room 13 Chair: Eve Van Cauter (United States) 12:30pm – 12:35pm Introduction Eve Van Cauter (United States) 12:35pm – 1:00pm Can the thermal environment be optimized to improve sleep quality?

Eus van Someren (Netherlands) 1:00pm – 1:25pm Roles of light and noise exposure on sleep duration, quality and timing Christian Cajochen (Switzerland) 1:25pm – 1:50pm Potential benefits of optimizing sleep position on sleep quality and sleep health Virend Somers (United States) 1:50pm – 2:00pm General discussion

PHILIPS: MANAGEMENT OF SLEEP PATIENTS WITH CARDIOVASCULAR DISEASE 12:30pm – 2:00pm | Room 14 Chair: Winfried Randerath (Germany)

TAKEDA PHARMACEUTICALS: NAVIGATING NARCOLEPSY: THE SCIENCE OF OREXIN AND DIAGNOSTIC CHALLENGES 12:30pm – 2:00pm | Room 15 Chair: Giuseppe Plazzi (Italy)

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1:05pm – 2:00pm Recognizing the patient journey and comorbidity diagnostic challenges Emmanuel Mignot (United States); Giuseppe Plazzi (Italy); Kiran Maski (United States)

PROSOMNUS SLEEP TECHNOLOGIES: PERSONALIZED CARE AND PRECISION MEDICINE IN SLEEP APNEA: EMERGING TECHNOLOGIES AND LATEST TRENDS IN TREATING SLEEP APNEA WITH NON-CPAP THERAPIES 12:30pm – 2:00pm | Room 21 Chair: Edward Sall (United States) 12:30pm – 12:35pm Introduction Len Liptak (United States) 12:35pm – 1:00pm Understanding how to increase non-CPAP therapy efficacy: Emphasis on patient selection including pathophysiological and respiratory endotyping/ phenotyping. FLOSAT: study protocol for a crossover clinical trial comparing the efficacy of MAD therapy with CPAP therapy as First Line OSA Treatments Olivier Vanderveken (Belgium) 1:00pm – 1:25pm Efficacy and efficacious mandibular position of a monolithic oral appliance; Advances in OAT Shouresh Charkhandeh (Canada) 1:25pm – 1:50pm Clinical utility of a novel intra-oral oximeter John Remmers (Canada) 1:50pm – 2:00pm Question and answer

12:30pm – 12:35pm Welcome Giuseppe Plazzi (Italy) 12:35pm – 1:05pm The orexin system and its relationship to narcolepsy Emmanuel Mignot (United States); Giuseppe Plazzi (Italy)

74 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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NEURIM PHARMACEUTICALS: ADVANCES IN INSOMNIA IN ASD – FROM RESEARCH TO CLINICAL PRACTICE 12:30pm – 2:00pm | Room 22 Chair: Oliviero Bruni (Italy)

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1:25pm – 1:50pm How are OSAHS guidelines evolving? Can real world evidence and virtual pathways influence policy in future?

Anita Simonds (United Kingdom) 1:50pm – 2:00pm Question and answer

12:30pm – 12:40pm Welcome and introduction Oliviero Bruni (Italy)

WORLD SLEEP DAY MEETING 1:00pm – 2:00pm | Room 31

12:40pm – 1:10pm Sleep problems in ASD: Genetic, biochemical, and other contributors Beth Malow (United States)

K03 | MONICA LEVY ANDERSEN: DO FEMALES SLEEP BETTER? INSIGHTS FROM BASIC AND CLINICAL STUDIES

1:10pm – 1:45pm Advances in insomnia treatment of children with ASD: Long-term efficacy and safety results of Slenyto (PedPRM) Paul Gringras (United Kingdom)

2:00pm – 2:45pm | Room 11

1:45pm – 2:00pm Question and answer

2:02pm – 2:45pm Keynote Presentation Monica Levy Andersen (Brazil)

RESMED: A NEW WAY TO RUN CLINICAL

2:00pm – 2:02pm Introduction Luigi Ferini-Strambi (Italy)

RESEARCH IN SLEEP MEDICINE: WHY DOES IT MATTER?

K04 | NICO DE VRIES: A VIABLE ALTERNATIVE

12:30pm – 2:00pm | Room 23 Chairs: Christoph Schöbel (Germany); Adam Benjafield (Australia)

2:00pm – 2:45pm | Room 14

12:30pm – 12:35pm Introduction Christoph Schöbel (Germany); Kimberly Sterling (United States) 12:35pm – 1:00pm What do experience and real-world evidence tell us about long-term outcomes for CPAP therapy?

Kimberly Sterling (United States) 1:00pm – 1:25pm Clinical outcomes of the French healthcare CPAP database analysis Jean Louis Pépin (France)

TO CPAP AND MAD TREATMENT IN OSA?

2:00pm – 2:02pm Introduction Thomas Penzel (Germany) 2:02pm – 2:45pm Keynote Presentation Nico de Vries (Netherlands)

K05 | YUN-KWOK WING: SLEEP AND PSYCHIATRIC DISORDERS: FROM EPIDEMIOLOGY TO TREATMENT 2:00pm – 2:45pm | Room 24 2:00pm – 2:02pm Introduction 2:02pm – 2:45pm Keynote Presentation Yun-Kwok Wing (Hong Kong)

75 | Scientific Program | WORLD SLEEP 2022

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S16: SLEEP AND THE TARGETS OF THE UNITED NATIONS’ SUSTAINABLE DEVELOPMENT GOAL 3 (GOOD HEALTH AND WELL-BEING) 3:00pm – 4:30pm | Room 11 Chair: Malcolm von Schantz (United Kingdom)

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3:22pm – 3:42pm The mysterious sleeping reptiles: what do they tell us about the evolution of sleep?

Paul-Antoine Libourel (France)

3:00pm – 3:02pm Introduction

3:42pm – 4:02pm Sleep duration and sleep homeostasis in birds is strongly dependent on season and moon phase Sjoerd van Hasselt (Netherlands)

3:02pm – 3:22pm The UN sustainable development goals and their relevance to sleep research and sleep medicine Malcolm von Schantz (United Kingdom)

4:02pm – 4:22pm Convergent and divergent aspects of REM sleep in birds and mammals Gianina Ungurean (Germany)

3:22pm – 3:42pm The role of sleep in cardiometabolic health in people living with HIV Karine Scheuermaier (South Africa)

4:22pm – 4:30pm Question and answer

3:42pm – 4:02pm Reducing mortality from NCDs (Target 3.4): Is there a role for sleep?

Kristen L Knutson (United States) 4:02pm – 4:22pm Can good sleep help to reduce deaths and injuries from road traffic accidents?

Claudia Moreno (Brazil) 4:22pm – 4:30pm Question and answer

S17: RECENT ADVANCES IN THE COMPARATIVE BIOLOGY OF SLEEP: FROM A REM-SLEEPING OCTOPUS TO SLEEPLESS BIRDS 3:00pm – 4:30pm | Room 13 Chair: Peter Meerlo (Netherlands) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm The octopus displays cyclic alternation of two sleep states analogous to SWS and REM sleep Sylvia Medeiros (Brazil)

S18: SUBSTANTIA NIGRA ECHOGENICITY AS A MARKER OF BRAIN IRON IN SLEEP-RELATED MOVEMENT DISORDERS 3:00pm – 4:30pm | Room 14 Chair: Diego Garcia-Borreguero (Spain) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm The role of TCS in the evaluation of parkinson syndromes Claudia Trenkwalder (Germany) 3:22pm – 3:42pm TCS in REM sleep behavior disorder Birgit Högl (Austria) 3:42pm – 4:02pm TCS as a marker of response to IV iron in RLS Celia Garcia Malo (Spain) 4:02pm – 4:22pm Exploring the possibilities of TCS in the pediatric population Laura Botta (Venezuela) 4:22pm – 4:30pm Question and answer

76 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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T01: EUROPEAN SOCIETY OF SLEEP TECHNOLOGISTS (ESST) SYMPOSIUM: SHOWCASING INNOVATIVE PRACTICE IN SLEEP TECHNOLOGY ACROSS EUROPE 3:00pm – 4:30pm | Room 15 Chair: Elizabeth (Lizzie) Hill (United Kingdom) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm Implementation of sleep studies during the COVID-19 pandemic in the Netherlands Caroline Blankvoort (Netherlands)

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3:18pm – 3:34pm Proper treatment can reverse the vicious cycle of pediatric SDB Clement Cheng-Hui Lin (Taiwan) 3:34pm – 3:50pm Rapid maxillary expansion (RME) for the treatment of pediatric SDB Paola Pirelli (Italy) 3:50pm – 4:06pm Nasomaxillary expansion for the treatment of obstructive sleep apnea Kasey K Li (United States)

3:22pm – 3:42pm Development of novel video-polysomnography scoring criteria for rhythmic movement disorder in children

4:06pm – 4:22pm Neutral supporting mandibular advancement device with tongue bead for passive myofunctional therapy: a long term follow-up study Michèle Hervy-Auboiron (France)

3:42pm – 4:02pm Evaluation of ambulatory self-applied polysomnography Erna Sif Arnardóttir (Iceland)

4:22pm – 4:30pm Question and answer

4:02pm – 4:22pm Future directions in sleep technology: Emerging sensors and how to make sense of them Sebastian Herberger (Germany)

S20: CARE OF OBSTRUCTIVE SLEEP APNEA IN HOSPITALIZED PATIENTS WITH CARDIOVASCULAR DISEASE: FROM RESEARCH TO CLINICAL PRACTICE

4:22pm – 4:30pm Question and answer

3:00pm – 4:30pm | Room 22 Chair: Cinthya Pena Orbea (United States)

S19: ORTHODONTIC AND ORTHOPEDIC

3:00pm – 3:02pm Introduction

TREATMENT FOR PEDIATRIC SLEEP DISORDERED BREATHING (SBD) 3:00pm – 4:30pm | Room 21 Chair: Kasey K Li (United States) 3:00pm– 3:02pm Introduction 3:02pm – 3:18pm Underdevelopment of craniofacial structures result in a vicious cycle with pediatric sleep disordered breathing Yu-Shu Huang (Taiwan)

3:02pm – 3:22pm Prevalence of Undiagnosed Obstructive Sleep Apnea in Hospitalized Patients with Cardiovascular Diseases and Screening Strategies in the Acute Setting Frances Chung (Canada) 3:22pm – 3:42pm Impact of Obstructive Sleep Apnea and Treatment Outcomes in Acute Decompensated Heart Failure: Where Do We Stand and Further Directions Rami Khayat (United States) 3:42pm – 4:02pm Obstructive Sleep Apnea in Acute Coronary Syndrome: Treat or Not Treat?

Manuel Sánchez de la Torre (Spain)

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4:02pm – 4:22pm Treatment Optimization Strategies in Obstructive Sleep Apnea: New Opportunities Cinthya Pena Orbea (United States)

O08: AGING AND DEVELOPMENTAL ISSUES

4:22pm – 4:30pm Question and answer

3:00pm – 3:15pm Sleep Fragmentation, Astrocyte Activation, and Cognitive Impairment in Older Adults Rebecca Wu (Canada)

S21: INSOMNIA AND COVID-19

3:15pm – 3:30pm Self-reported sleep disturbances attributed to light, temperature, and noise decline linearly with age: a big-data analysis of 92,702 users Elie Gottlieb (United States)

3:00pm – 4:30pm | Room 24 Chair: Charles Morin (Canada) 3:00pm – 3:02pm Introduction 3:02pm – 3:18pm Insomnia and psychological symptoms in the first wave of the pandemic Charles Morin (Canada) 3:18pm – 3:34pm Sleep and mental health during the COVID pandemic Rebecca Robillard (Canada) 3:34pm – 3:50pm Insomnia in patients with covid-19 Yun-Kwok Wing (Hong Kong) 3:50pm – 4:06pm Drug treatment in covid-19 insomnia Ingo Fietze (Germany) 4:06pm – 4:22pm Insomnia in health care workers Babak Amra (Iran) 4:22pm – 4:30pm Question and answer

3:00pm – 4:30pm | Room 31

3:30pm – 3:45pm Obstructive sleep apnea and cognitive decline in the elderly: the HypnoLaus study Nicola Andrea Marchi (Switzerland) 3:45pm – 4:00pm Non-parametric actigraphy-derived measures differ in dementia with Lewy bodies compared to Alzheimer’s dementia: a feasibility study Greg J. Elder (United Kingdom) 4:00pm – 4:15pm Sleep moderates the association between stress at work and incident dementia: study from the Survey of Health, Ageing and Retirement in Europe Xiao Tan (Sweden) 4:15pm – 4:30pm Sleep Measurement Heterogeneity in Mild Cognitive Impairment and Early Dementia - Towards a Core Outcome Set: A Scoping Review Hamish Duncan Morrison (United Kingdom)

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O09: YOUNG INVESTIGATOR AWARD

O10: NEUROLOGIC SLEEP DISORDERS

3:00pm – 4:30pm | Room 32

3:00pm – 4:30pm | Room 33

3:00pm – 3:15pm Sleepless on the road: Are mothers of infants with pediatric insomnia at risk for impaired driving?

Michal Kahn (Australia)

3:00pm – 3:15pm Sleep-wake misperception. A comprehensive analysis of a large sleep lab cohort Schirin Hunziker (Switzerland)

3:15pm – 3:30pm Larger hypothalamic volume in histamine neuron area in narcolepsy type 1 Hilde T. Juvodden (Norway)

3:15pm – 3:30pm APOE ε4 genotype and sleep disturbance in individuals with and without dementia Jonathan Blackman (United Kingdom)

3:30pm – 3:45pm Cerebrospinal-fluid biomarkers and blood-brain barrier alteration may be useful to predict the phenoconversion of patients with idiopathic/isolated REM sleep behaviour disorder Mariana Fernandes (Italy)

3:30pm – 3:45pm Sleep modulation in Parkinson’s Disease patients with Deep Brain Stimulation: the role of frequency variations Eleonora Del Prete (Italy)

3:45pm – 4:00pm Association of sleep microstructure with incident hypertension in a population-based sample: The HypnoLaus study Mathieu Berger (Switzerland) 4:00pm – 4:15pm Identification and validation of a brain glucose metabolism conversion pattern in idiopathic REM Behaviour Disorder Beatrice Orso (Italy) 4:15pm – 4:30pm Anti-hypothalamic autoantibodies in patients with Narcolepsy Andrea Donniaquio (Italy)

3:45pm – 4:00pm Association of circadian distribution of seizures with sleep architecture and abnormal sleep phenomena in epilepsy Mariam Isayan (Armenia) 4:00pm – 4:15pm Effects of epilepsy surgery on sleep macrostructure and microstructure in patients with drug-resistant temporal lobe epilepsy due to hippocampal sclerosis: a prospective controlled polysomnographic study Andrea Romigi (Italy)

S22: SURPRISE POTENTIALS ACROSS SLEEP AND WAKEFULNESS – TWO SIDES OF THE SAME COIN? 4:45pm – 6:15pm | Room 11 Chair: Francesca Siclari (Switzerland) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm The large brain potentials elicited by surprising stimuli in wakefulness Giandomenico Iannetti (Italy) 5:07pm – 5:27pm The EEG signature of the Locus Coeruleus phasic response Oxana Eschenko (Germany)

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5:27pm – 5:47pm The quantum nature of K-complexes and CAP during sleep Liborio Parrino (Italy) 5:47pm – 6:07pm K-complexes and delta waves in human sleep and their relation to dreams Francesca Siclari (Switzerland) 6:07pm – 6:15pm Question and answer

S23: NEW INSIGHTS SLEEP NEUROPHYSIOLOGY PROVIDES ABOUT BIDIRECTIONAL EFFECTS OF SLEEP ON FOCAL-ONSET EPILEPSIES IN ADULTS 4:45pm – 6:15pm | Room 13 Chair: Madeleine Grigg-Damberger (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Contribution of sleep to better define the epileptic focus and post-surgical outcome Birgit Frauscher (Canada) 5:07pm – 5:27pm Roles of sleep and apnea in sudden unexpected death In epilepsy (SUDEP) Risk Nancy Foldvary-Schaefer (United States) 5:27pm – 5:47pm Objective pathological sleepiness and difficulty staying awake and alert highly prevalent in unselected adults with focal-onset epilepsies Madeleine Grigg-Damberger (United States) 5:47pm – 6:07pm Dissecting sleep-related hypermotor epilepsy (SHE) from NREM parasomnias (DoA): The role of videopolysomnographic (v-PSG) analysis Federica Provini (Italy) 6:07pm – 6:15pm Question and answer

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S24: SLEEP AND OUR SOCIAL LIVES: NOVEL ASSOCIATIONS, MECHANISMS AND DIRECTIONS FROM EXPERIMENTAL RESEARCH 4:45pm – 6:15pm | Room 14 Chair: Candice A. Alfano (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Children’s emotional expressivity after sleep restriction forecasts social problems years later Candice A. Alfano (United States) 5:07pm – 5:27pm Sleepy and secluded: Sleep disturbances are associated with connectedness in early adolescent social networks Cara Palmer (United States) 5:27pm – 5:47pm Can memory reactivation in deep sleep enhance psychotherapeutic change in emotional socially aversive memories?

Dominique Recher (Switzerland) 5:47pm – 6:07pm Sleep restriction reduces positive social emotions and desire to connect with others Cara Palmer (United States) 6:07pm – 6:15pm Question and answer

DS1: GLOBAL SLEEP HEALTH INITIATIVE 4:45pm - 6:15pm | Room 15 Chair: Diane Lim (United States) 4:45pm – 4:50pm Introduction: Challenges to promoting Global Sleep Health Initiative Diane Lim (United States) 4:50pm – 5:10pm Challenges to promoting Sleep Health in Iran Arezu Najafi (Iran)

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5:10pm – 5:30pm Challenges to promoting Sleep Health in Australia Peter Eastwood (Australia) 5:30pm – 5:50pm Challenges to promoting Sleep Health in the United States Marishka Brown (United States) 5:50pm – 6:05pm Challenges to promoting health issues from the perspective of the WHO Fiona Bull (Switzerland) 6:05pm – 6:15pm Panel Discussion about how to increase Sleep Health in your country Phyllis Zee (United States); Han Fang (China); Allan I Pack (United States)

S25: OPTIMIZING THE AIRWAY ON A CONTINUUM OF MEDICAL AND DENTOFACIAL CARE FOR SLEEP-DISORDERED BREATHING 4:45pm – 6:15pm | Room 21 Chair: Leopoldo P. Correa (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm Functional approach of orofacial structure evaluation and restoration: Growth modification for all ages Audrey Yoon (United States) 5:03pm – 5:19pm Cone Beam CT evaluation of skeletal and nasomaxillary complex volume changes after rapid maxillary expansion in OSA children Paola Pirelli (Italy) 5:19pm – 5:35pm The role of sleep disturbance and OSA in systemic inflammation and its impact on orofacial disorders Ji Woon Park (Korea, Republic of)

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5:51pm – 6:07pm A multidisciplinary approach for treatment of pediatric OSA: Putting it all together Daniel Ng (Hong Kong) 6:07pm – 6:15pm Question and answer

S26: NOVEL STRATEGIES TO PROMOTE THE MULTIPLE DIMENSIONS OF SLEEP HEALTH IN EARLY CHILDHOOD 4:45pm – 6:15pm | Room 22 Chair: Monica Ordway (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Promoting sleep health in early childhood at the community, interpersonal, and individual level Monica Ordway (United States) 5:07pm – 5:27pm Sleep health promotion using computer decision support systems in pediatric primary care clinics Sarah Honaker (United States) 5:27pm – 5:47pm Dyadic behavioral treatments impact on sleep and socio-emotional development in early childhood Guanghai Wang (China) 5:47pm – 6:07pm Big data generated from auto-videosomnography used to examine the impact of parental use of behavioral sleep interventions Michal Kahn (Australia) 6:07pm – 6:15pm Question and answer

5:35pm – 5:51pm Restoring missed milestones in sleep-disordered breathing with precision surgery Stanley Liu (United States)

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S27: CORTICAL REGULATION OF SLEEP 4:45pm – 6:15pm | Room 23 Chair: Vladyslav Vyazovskiy (United Kingdom) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm Neo- and archicortical control of vigilance states and sleep homeostasis Lukas B. Krone (United Kingdom) 5:03pm – 5:19pm Thalamic matrix cells orchestrate cortical activity in both wakefulness and NREM sleep Sakiko Honjoh (Japan) 5:19pm – 5:35pm Contribution of cortical sleep-active interneurons to sleep homeostasis Thomas S. Kilduff (United States) 5:35pm – 5:51pm Prefrontal cortex regulation of sleep William Wisden (United Kingdom) 5:51pm – 6:07pm Cortical astrocytes regulate specific sleep features Kira Poskanzer (United States) 6:07pm – 6:15pm Question and answer

S28: BRAIN CHANGES IN ISOLATED REM SLEEP BEHAVIOR DISORDER: AN UPDATE OF RECENT ADVANCES

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5:07pm – 5:27pm EEG abnormalities in iRBD: From classical analyses to new artificial intelligence-based findings Matteo Cesari (Austria) 5:27pm – 5:47pm Abnormal FDG PET patterns in neurodegenerative diseases: Application in iRBD Sanne Meles (Netherlands) 5:47pm – 6:07pm Substantia nigra iron and neuromelanin changes in patients with iRBD using multimodal MRI Rahul Gaurav (France) 6:07pm – 6:15pm Question and answer

O11: SLEEP DISORDERED BREATHING: BASIC MECHANISMS 4:45pm – 6:15pm | Room 31 4:45pm – 4:58pm Combination of atomoxetine with the novel antimuscarinic aroxybutynin improves mild to moderate OSA Russell Rosenberg (United States) 4:58pm – 5:11pm MRI measurement of brain iron content in obstructive sleep apnea: the HypnoLaus study Nicola Andrea Marchi (Switzerland) 5:11pm – 5:24pm Study of the Effect of Obstructive Sleep Apnea on Telomere Length and its Associated Mechanisms Priscila Tempaku (Brazil) 5:24pm – 5:37pm A study in Physiological Activation Responses to Posture Shifts in Sleep and The Impact of Supine Avoidance Alarms Matthew Rahimi (Australia)

4:45pm – 6:15pm | Room 24 Chair: Shady Rahayel (Canada) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Structural gray matter changes inform on the mechanisms underlying propagation in iRBD Shady Rahayel (Canada)

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5:37pm – 5:50pm Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based mendelian randomization study Heming Wang (United States) 5:50pm – 6:03pm A randomized controlled trial exploring safety and tolerability of sulthiame in sleep apnea Jan Hedner (Sweden)

O12: SLEEP HEALTH, CIRCADIAN RHYTHMS, AND DEVELOPMENTAL ISSUES 4:45pm – 6:15pm | Room 32 4:45pm – 4:58pm Wearable and mobile technology to characterize daily dynamics and interaction of sleep and daily stress, pre-sleep worry and mood in adolescent insomnia Luca Menghini (Italy) 4:58pm – 5:11pm A model-based investigation of physiological factors that promote irregular sleep/wake patterns Dorothee Fischer (Germany) 5:11pm – 5:24pm Better Sleep Health at Baseline is Associated with Greater Weight Loss at 6 Months in a TechnologySupported Behavioral Weight Loss Intervention Trial Christopher C. Imes (United States) 5:24pm – 5:37pm Cardiorespiratory Fitness Is Associated with Phase Advanced Circadian Rhythms in Healthy Adolescents Ariel B Neikrug (United States) 5:37pm – 5:50pm Evening screen time, sleep and diurnal type in preschool and primary school children Luis Pires (Portugal)

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O13: PARASOMNIAS 4:45pm – 6:15pm | Room 33 4:45pm – 5:00pm The Arousal Disorders Questionnaire: a new and effective screening tool Giuseppe Loddo (Italy) 5:00pm – 5:15pm Paroxysmal arousals in Sleep-related Hypermotor Epilepsy (SHE) and Simple arousal movements in Disorders of Arousal (DoA): semiological and clinical features make a difference Giuseppe Loddo (Italy) 5:15pm – 5:30pm EEG activation in simple and complex episodes of Disorders of Arousal: a spectral analysis study Greta Mainieri (Italy) 5:30pm – 5:45pm Low specificity of screening questionnaires for REM sleep behavior disorder Ambra Stefani (Austria) 5:45pm – 6:00pm Effects of sleep deprivation on sleepwalking: Role of sleepwalkers’ clinical characteristics Cloé Blanchette-Carrière (Canada)

POSTER ABSTRACT: GROUP A 5:30pm – 6:15pm | Poster Hall

POSTER ABSTRACT: GROUP B 6:15pm - 7:00pm | Poster Hall

SOCIAL EVENT: DINNER 7:00pm – 11:00pm | Palazzo Brancaccio

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WORLD SLEEP SOCIETY: MEMBERSHIP MEETING 7:05am – 7:55am | Room 21 Chair: Phyllis Zee (United States)

K06 | MICHAEL GRADISAR: TREATING INSOMNIA IN SCHOOL KIDS: HOW DOES IT WORK? 8:00am – 8:45am | Room 11 8:00am – 8:02am Introduction Oliviero Bruni (Italy)

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9:18am – 9:34am Blood pressure as a marker of cardiovascular risk in OSA patients Martino Pengo (Italy) 9:34am – 9:50am A bespoke approach towards patients with OSA and hypertension: What do we know about specific cohorts of patients?

9:50am – 10:06am The cardiorespiratory system in the context of sleepdisordered breathing: Do we need to develop different markers for disease severity?

Allan I Pack (United States) 10:06am – 10:22am Understanding phenotypes predicting response-totreatment: the ANDANTE collaboration Esther I Schwarz (Switzerland)

8:02am – 8:45am Keynote Presentation Michael Gradisar (Australia)

K07 | LUIGI FERINI-STRAMBI: RESTLESS LEGS SYNDROME: A COMPLEX NIGHT-DAY DISORDER 8:00am – 8:55am | Room 24

10:22am – 10:30am Question and answer

S30: REGULATION OF MUSCLE TONE IN NARCOLEPSY

8:00am – 8:02am Introduction Birgit Högl (Austria)

9:00am – 10:30am | Room 13 Chair: Carrie Mahoney (United States)

8:02am – 8:45am Keynote Presentation Luigi Ferini-Strambi (Italy)

9:00am – 9:02am Introduction

8:45am to 8:55am Welcome from the Italian Ministry of Health Pierpaolo Sileri, Undersecretary of State at the Ministry of Health (Italy)

S29: TWO-FOR-ONE: TREATING OBSTRUCTIVE SLEEP APNOEA TO REDUCE CARDIOVASCULAR RISKS, WHERE ARE WE NOW? 9:00am – 10:30am | Room 11 Chair: Joerg Steier (United Kingdom) 9:00am – 9:02am Introduction 9:02am – 9:18am Obstructive sleep apnoea as a cardiovascular risk factor: An update Thomas Penzel (Germany)

9:02am – 9:22am Pathophysiology of narcolepsy Claudio Bassetti (Switzerland) 9:22am – 9:42am REM sleep behavior disorder and REM sleep without atonia in Narcolepsy Elena Antelmi (Italy) 9:42am – 10:02am Role of the amygdala in emotion-triggered cataplexy Carrie Mahoney (United States) 10:02am – 10:22am The biology of REM sleep and the role of the SLD in regulating cataplexy John Peever (Canada) 10:22am – 10:30am Question and answer

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S31: DIGITAL DELIVERY OF CBT FOR INSOMNIA: AN INTERNATIONAL PERSPECTIVE 9:00am – 10:30am | Room 14 Chair: Charles Morin (Canada) 9:00am – 9:02am Introduction 9:02am – 9:18am Early data from a prescription digital therapeutic delivering CBT for insomnia Charles Morin (Canada) 9:18am – 9:34am Digital CBT-I in the general population and secondary care in Norway Håvard Kallestad (Norway) 9:34am – 9:50am The clinical and cost-effectiveness of guided online CBT for insomnia (i-Sleep) in primary care Annemieke van Straten (Netherlands) 9:50am – 10:06am Effects of the Sleep Ninja smartphone application on adolescent insomnia: Results from a randomized controlled trial Aliza Werner-Seidler (Australia) 10:06am – 10:22am Autonomous virtual agents: A new digital solution to diagnose and treat sleep disorders related to psychosocial stress Pierre Philip (France) 10:22am – 10:30am Question and answer

S32: SLEEP DISORDERS AND CARDIOVASCULAR DYSFUNCTION: BEYOND SLEEP-DISORDERED BREATHING 9:00am – 10:30am | Room 15 Chair: Alessandro Silvani (Italy) 9:00am – 9:02am Introduction 9:02am – 9:18am Cardiovascular function and dysfunction during sleep: a translational perspective Alessandro Silvani (Italy)

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9:18am – 9:34am Effect of circadian misalignment on cardiovascular function Debra J. Skene (United Kingdom) 9:34am – 9:50am Cardiovascular and autonomic alterations in narcolepsy type 1 and in restless legs syndrome Lucie Barateau (France) 9:50am – 10:06am Cardiovascular disease risk and insomnia: Do phenotypes matter?

Suzanne Bertisch (United States) 10:06am – 10:22am New generation of multi-sensor wearable devices: Beyond sleep tracking Massimiliano de Zambotti (United States) 10:22am – 10:30am Question and answer

S33: FROM SOCIETIES ACROSS THE GLOBE TO CELLS: LEVERAGING TECHNOLOGY FROM THE EXPOSOME INITIATIVE TO INTEGRATE SLEEP, CHRONOBIOLOGY, SOCIAL SCIENCE, AND ENVIRONMENTAL HEALTH RESEARCH 9:00am – 10:30am | Room 21 Chair: Chandra Jackson (United States) 9:00am – 9:02am Introduction 9:02am – 9:22am Overview of the exposome and relevance to research on sleep health and sleep disparities Chandra Jackson (United States) 9:22am – 9:42am Measuring the external sleep exposome (or physical and social determinants) Lauren Hale (United States) 9:42am – 10:02am Measuring the internal sleep exposome (or biological determinants) and integration with the external exposome Gary Miller (United States)

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10:02am – 10:22am Implications and next steps for sleep health and disparities research across the globe Azizi Seixas (United States)

9:02am – 9:22am Individualized treatment from phenotyping to practical implication Winfried Randerath (Germany)

10:22am – 10:30am Question and answer

9:22am – 9:42am Lifestyle intervention: What is enough dose of exercise?

Jose Miguel Saavedra Garcia (Iceland)

S34: SLEEP IS FOR COGNITION: THE IMPACT OF SLEEP DEPRIVATION AND INSOMNIA ON COGNITIVE FUNCTIONING OF CHILDREN AND ADOLESCENTS 9:00am – 10:30am | Room 22 Chairs: Reut Gruber (Canada); Oliviero Bruni (Italy) 9:00am – 9:02am Introduction 9:02am – 9:22am Executive functions in children with chronic insomnia Oliviero Bruni (Italy) 9:22am – 9:42am Mind-wandering, attentional performance, and sleep in pediatric populations Karen Spruyt (France) 9:42am – 10:02am Sleep consolidation: Sleep-dependent memory consolidation across development Kerstin Hödlmoser (Austria) 10:02am – 10:22am Executive functions in adolescents with insomnia Reut Gruber (Canada) 10:22am – 10:30am Question and answer

S35: A “SLEEP REVOLUTION” BEYOND THE PAP -PASSIVE TREATMENT AND ACTIVE TRAINING IN SLEEP BREATHING DISORDERS 9:00am – 10:30am | Room 23 Chair: Harald Hrubos-Strøm (Norway) 9:00am – 9:02am Introduction

9:42am – 10:02am Orofacial myofunctional training with autofeedback (OMTa) Harald Hrubos-Strøm (Norway) 10:02am – 10:22am Pharmacological therapies in sleep breathing disorders Jan Hedner (Sweden) 10:22am – 10:30am Question and answer

S36: ISOLATED REM SLEEP BEHAVIOR DISORDER: UPDATE AND FUTURE DIRECTIONS 9:00am – 10:30am | Room 24 Chair: Aleksandar Videnovic (United States) 9:00am – 9:02am Introduction 9:02am – 9:22am Update on screening and diagnosis of REM sleep behavior disorder and future directions Ambra Stefani (Austria) 9:22am – 9:42am New insights on isolated RBD from genetic studies Ziv Gan-Or (Canada) 9:42am – 10:02am Update on biomarkers in isolated RBD and future directions Mitchell Miglis (United States) 10:02am – 10:22am Current and upcoming clinical trials in isolated REM sleep behavior disorder Aleksandar Videnovic (United States) 10:22am – 10:30am Question and answer

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O14: DENTAL SLEEP MEDICINE 9:00am – 10:30am | Room 31 9:00am – 9:15am Long-term dentoskeletal side effects of mandibular advancement therapy in patients with obstructive sleep apnea: data from the Pays de la Loire Sleep Cohort Nicolas Badlini (France) 9:15am – 9:30am Biomimetic Oral Appliance Therapy (BOAT): Novel Oral Appliance Treatment for Obstructive Sleep Apnea Administered by Dentists Seth Heckman (Canada) 9:30am – 9:45am The prevalence of treatment-emergent central sleep apnea in mandibular advancement device therapy Simon Hellemans (Belgium) 9:45am – 10:00am Impact of Rapid Maxillary Expansion on Adenotonsillar Hypertrophy in Children Christine Hong (United States)

O15: SLEEP HEALTH 9:00am – 10:30am | Room 32 9:00am – 9:15am Effects of impaired sleep on autonomic stress during a simulated 4-month space mission Naima Laharnar (Germany) 9:15am – 9:30am Sleep as a major determinant for mental health outcomes in elite Australian Football League (AFL) athletes Elise R. Facer-Childs (Australia)

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9:30am – 9:45am Poor sleep quality may contribute to dysfunctional illness perception, physical and emotional distress in hospitalized patients: results of a national survey of the Italian society of consultation-liaison psychiatry Laura Palagini (Italy) 9:45am – 10:00am Estimated Sleep-Wake Patterns Obtained from a Large U.S. Sample by Home-Based Under-Mattress Monitoring Devices Jennifer Zitser Koren (United States)

O16: ENVIRONMENTAL AND GENTIC ASPECTS OF SLEEP IN CHILDREN AND ADOLESCENTS 9:00am – 10:30am | Room 33 9:00am – 9:15am Sleep disorders and neuropsychiatric disorders in a pediatric sample of tuberous sclerosis complex: a questionnaire-based study Romina Moavero (Italy) 9:15am – 9:30am The effect of screen exposure on sleep in adolescents: both timing and duration are important Sarah Hartley (France) 9:30am – 9:45am Are some children genetically predisposed to poor sleep?

A polygenic risk study Desana Kocevska (Netherlands) 9:45am – 10:00am Morning perception of sleep, stress and mood, and its relationship with overnight physiological sleep processes in adolescents Benedetta Albinni (Italy)

EXHIBIT HALL 9:30am – 4:00pm | Exhibit Hall

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S37: OREXIN RECEPTOR ANTAGONISTS IN THE TREATMENT OF INSOMNIA 10:45pm – 12:15pm | Room 11 Chair: Clete Kushida (United States) 10:45am – 10:55am Introduction Clete Kushida (United States) 10:55am – 11:15am Current landscape of pharmacology treatments for insomnia Phyllis Zee (United States) 11:15am – 11:35am Interplay of pharmacologic approaches and cognitive behavioral therapy for insomnia (CBTI) in the management of insomnia Charles Morin (Canada) 11:35am – 11:55am Effects of orexin receptor antagonists on sleep and sleep architecture Claudio Liguori (Italy) 11:55am – 12:15pm Role of orexin receptor antagonists in insomnia and other comorbidities Russell Rosenberg (United States)

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11:19am – 11:35am Disrupted neural correlates of anesthesia and sleep underlie early circuit dysfunctions in Alzheimer models Inna Slutsky (Israel) 11:35am – 11:51am Enhancement of human memory by prefrontal deep brain stimulation synchronized to medial temporal lobe during sleep Yuval Nir (Israel) 11:51am – 12:07pm Effects of Alzheimer’s disease pathophysiology on sleep dependent memory Bryce Mander (United States) 12:07pm – 12:15pm Question and answer

S39: COVID-19 AND SLEEP APNEA: IS TREATMENT OF OBSTRUCTIVE SLEEP APNEA A KEY STRATEGY TO IMPROVE OUTCOMES OF PATIENTS WITH COVID-19 PNEUMONIA? 10:45pm – 12:15pm | Room 14 Chair: Luciano Drager (Brazil); Jacek Wolf (Poland) 10:45am – 10:47am Introduction

S38: SLEEP AND MEMORY: EFFECTS OF AGING, DEMENTIA, AND INTERVENTIONS ON NEUROBIOLOGICAL MECHANISMS

10:47am – 11:03am Obesity and COVID-19 – lessons from Milan Nicola Montano (Italy)

10:45pm – 12:15pm | Room 13 Chair: Yuval Nir (Israel)

11:03am – 11:19am Obstructive sleep apnea and obesity Krzysztof Narkiewicz (Poland)

10:45am – 10:47am Introduction 10:47am – 11:03am Neuronal mechanisms of sleep dependent regulation of emotional memory and anxiety Gabrielle Girardeau (France) 11:03am – 11:19am How do slow waves affect multi-area coordinated reactivation and memory consolidation? Insights from intracranial electrophysiology Karunesh Ganguly (United States)

11:19am – 11:35am Progressive hypoxia: A pivotal pathophysiologic mechanism determining progression of COVID-19 pneumonia Virend Somers (United States) 11:35am – 11:51am Hypoxemia and mortality in COVID-19 – lessons from Wuhan Jiang Xie (China)

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11:51am – 12:07pm Clinical experiences related to early oxygen supplementation and sleep apnea treatment in patients with COVID-19 pneumonia – lessons from the Czechia Tomas Kara (Czech Republic) 12:07pm – 12:15pm Question and answer

S40: SLEEP AND THE AUTONOMIC NERVOUS SYSTEM: A BIDIRECTIONAL RELATIONSHIP 10:45pm – 12:15pm | Room 15 Chair: Mitchell Miglis (United States)

10:47am – 11:07am Autonomic dysfunction in the CNS hypersomnias Mitchell Miglis (United States) 11:07am – 11:27am Fatal Familial Insomnia: A model of sleep and autonomic dysfunction Luca Baldelli (Italy) 11:27am – 11:47am Sleep apnea and cardiovascular autonomic dysfunction Carolina Lombardi (Italy) 11:47am – 12:07pm Restless legs syndrome/Willis Ekbom disease and autonomic dysfunction Anupama Gupta (India) 12:07pm – 12:15pm Question and answer

S41: FROM PEDIATRICS TO ADULTS: OUTCOME OF MAXILLARY EXPANSION FOR THE TREATMENT OF PEDIATRIC TO ADULT SLEEP-DISORDERED BREATHING

10:45am – 10:47am Introduction

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10:47am – 11:03am Pediatric and adult maxillary expansion outcome: systematic reviews Christian Calvo (Spain) 11:03am – 11:19am Pediatric to Adult Protocol for Maxillary Expansion Audrey Yoon (United States) 11:19am – 11:35am Understanding the “4-Dimentional” approach in maxillary expansion: Highlighting Symmetry and Posture Silvia Martins (Spain) 11:35am – 11:51am Biohacking Maxillary Expansion for Airway Health Christine Hong (United States)

10:45am – 10:47am Introduction

10:45pm – 12:15pm | Room 21 Chair: Stanley Liu (United States)

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11:51am – 12:07pm Maxillary Expansion is the Missing Link in Contemporary Sleep Surgery Stanley Liu (United States) 12:07pm – 12:15pm Question and answer

ON DEMAND ONLY

S42: COVID-19 LIFESTYLE CHANGES ACROSS CONTINENTS, ITS IMPACT ON CHILDHOOD SLEEP Chair: Karen Spruyt (France) Introduction Sleep of Chinese preschoolers in a rapidly evolving COVID-19 pandemic Hui Tang (China); Zhijun Liu (China) Sleep and mood-state of children and adolescents with attention deficit hyperactivity disorder (ADHD) during Italian COVID-19 lockdown Maria Grazia Melegari (Italy) Adolescent sleep during the pandemic: Bad news or good news Judith Owens (United States) COVID-19 lockdown, altered family sleep in South America Magda Lahorgue Nunes (Brazil)

89 | Scientific Program | WORLD SLEEP 2022

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MARCH 11

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MARCH 12

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MARCH 13

O17: PSYCHIATRIC DISORDERS AFFECTING

MON

MARCH 14

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MARCH 15

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MARCH 16

O18: YOUNG INVESTIGATOR AWARD

SLEEP/WAKE 10:45am – 12:15pm | Room 23

10:45am – 12:15pm | Room 24

10:45am – 11:00am The effect of sleep deprivation on behavioral response inhibition to emotional stimuli of young adult men with Attention Deficit Hyperactivity Disorder Ami Cohen (Israel)

10:45am – 11:00am Map2k5 deficient mice manifest phenotypes and pathological changes of dopamine deficiency in the central nervous system Yumeng Huang (China)

11:00am – 11:15am Insomnia and eveningness are independent transdiagnostic markers of poor mental health across the lifespan Dina Sarsembayeva (Netherlands)

11:00am – 11:13am Obstructive sleep apnea-related blood oxygen desaturation is associated with preferential consolidation of negative memories in older adults Miranda G. Chappel-Farley (United States)

11:15am – 11:30am Sleep Disturbances and Mental Health: A Transdiagnostic View of Sleep Disorders Symptoms in a Representative Canadian Sample Rebecca Robillard (Canada)

11:13am – 11:26am Changes in Sleep Architecture During Long-Duration Spaceflight Oliver Piltch (United States)

11:30am – 11:45am Effectiveness of Targeting Insomnia and Nightmares in Post-Traumatic Stress Disorder: A Transdiagnostic Intervention Ashley Nixon (Canada) 11:45am – 12:00pm Variability in Sleep Duration and Sleep Timing are Associated with Suicidal Ideation in Adolescents and College Students Enrolled in an Intensive Outpatient Program Peter L. Franzen (United States)

11:26am – 11:39am The circadian expressions of metabolism genes in human adipocytes: the impact of melatonin Marie Gombert (Spain) 11:39am – 11:52am Chronotype advance as a predictor of subsequent cognitive function and brain volume regression: a 4-year longitudinal cohort study Hyeon Jin Kim (Korea, Republic of) 11:52am – 12:05pm Obstructive sleep apnea impact on physiology: insights from a mouse model and a case-control study Laetitia S. Gaspar (Portugal) 12:05pm – 12:18pm Brain atrophy in REM sleep behavior disorder is shaped by gene expression and structural connectivity Shady Rahayel (Canada)

90 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

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MARCH 12

MARCH 13

O19: SLEEP DISORDERED BREATHING:

MON

MARCH 14

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MARCH 15

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MARCH 16

O21: BASIC RESEARCH

CONTROVERSIES AND NEW DIRECTIONS 10:45am – 12:15pm | Room 31

10:45am – 12:30pm | Room 33

10:45am – 11:00am Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea: The INTERAPNEA Randomised Controlled Trial Almudena Carneiro-Barrera (Spain)

10:45am – 10:58am Designer Receptors Exclusively Activated by Designer Drugs Treatment of Sleep-disordered Breathing Thomaz Fleury Curado (United States)

11:00am – 11:15am A novel physiological-based model to predict treatment outcomes in children with obstructive sleep apnoea Danny Eckert (Australia) 11:15am – 11:30am The severity and morphology of intermittent hypoxemias are related to impaired daytime alertness Purbanka Pahari (Finland) 11:30am – 11:45am Pathophysiological mechanisms of exacerbated OSA with lighter sleep Laura K. Gell (United States)

10:58am – 11:11am Selective Thermal Stimulation to Manipulate the Circadian Component of Sleep Regulation Shahab Haghayegh (United States) 11:11am – 11:24am Brain respiratory pulsatility of fast fMRI stabilizes during NREM Stage 2 sleep Heta Helakari (Finland) 11:24am – 11:37am Neurons in prefrontal cortex respond to sleep deprivation by initiating sleep preparatory behaviour and NREM sleep Kyoko Tossell (United Kingdom)

10:45am – 12:15pm | Room 32

11:37am – 11:50am ResTNet-Arousals: A end-to-end deep learning approach to arousal detection Sigurdur AE Jonsson (Iceland)

10:45am – 11:00am Multiple therapeutical Bleeding in Patients with Polyglobulia and Periodic Limb Movements Celio Martinez (Spain)

11:50am – 12:03pm Neuronal activity of hippocampus and temporal cortex during central sleep apnea in cats Alexandra Limanskaya (Russian Federation)

O20: RLS AND SLEEP-RELATED MOVEMENT DISORDERS: CLINICAL CORRELATES

11:00am – 11:15am A review of iron deficiency guidelines in the context of iron deficiency-associated sleep/wake behaviours Scout McWilliams (Canada) 11:15am – 11:30am Periodic limb movements among persons with epilepsy – a retrospective polysomnography study Laurel Charlesworth (Canada) 11:30am – 11:45am Effects of acute exposure to altitude on Restless Legs Syndrome Ambra Stefani (Austria)

91 | Scientific Program | WORLD SLEEP 2022

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MARCH 11

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MARCH 12

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MARCH 13

12:03pm – 12:16pm Genotype Modulates Slow Wave Sleep and EEG Spectral Power Following Total Sleep Deprivation Hans van Dongen (United States) 12:16pm – 12:29pm Sleep EEG spectral exponents and maximal peak frequencies in consecutive NREM periods: possible markers for sleep regulation Csenge G.Horváth (Hungary) 12:29pm – 12:42pm Effects of clozapine-N-oxide and Compound 21 on sleep in laboratory mice Lukas B. Krone (United Kingdom)

IDORSIA: INSOMNIA – A WAKE-UP CALL 12:30pm – 2:00pm | Room 11 Chair: Charles Morin (Canada) 12:30pm – 12:40pm Welcome and introduction Charles Morin (Canada) 12:40pm – 1:00pm Insomnia: a 24-hour condition with long-term implications Luigi Ferini-Strambi (Italy) 1:00pm – 1:20pm Outcomes that matter to patients with insomnia David Neubauer (United States) 1:20pm – 1:40pm Current treatment options for insomnia Goran Hajak (Germany)

MON

MARCH 14

TUES

MARCH 15

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MARCH 16

AVADEL PHARMACEUTICALS: ADDRESSING PATIENT NEEDS IN THE ADVANCEMENT OF NARCOLEPSY TREATMENT 12:30pm – 2:00pm | Room 13 Chairs: Yves Dauvilliers (France); Michael Thorpy (United States) 12:30pm – 12:35pm Welcome and introduction Yves Dauvilliers (France) 12:35pm – 12:55pm American Academy of Sleep Medicine 2021 Clinical Practice Guidelines of Adult Narcolepsy Michael Thorpy (United States) 12:55pm – 1:10pm European Guideline and Expert Statements on the Management of Adult Narcolepsy Yves Dauvilliers (France) 1:10pm – 1:30pm Understanding the Impact and Addressing Nocturnal Symptoms Clete Kushida (United States) 1:30pm – 1:50pm Helping Patients Weigh the Options: Shared Decision Making in Narcolepsy Treatment Anne Morse (United States), with Katie, a person living with narcolepsy 1:50pm – 2:00pm Panel Discussion with Q&A

1:40pm – 2:00pm Panel discussion

92 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

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MARCH 12

MARCH 13

BIOPROJET: EDS MANAGEMENT IN OSA, THE NEW APPROACHES 12:30pm – 2:00pm | Room 15 Chair: Maria Rosaria Bonsignore (Italy)

TUES

MARCH 15

WED

MARCH 16

1:20pm – 1:40pm Endo-phenotyping, at scale, from a clinical PSG Eysteinn Finnsson (Iceland) 1:40pm – 2:00pm Panel Discussions

12:30pm – 12:32pm Introduction

RESMED: HOW TO IMPROVE SLEEP APNOEA

12:32pm – 12:52pm EDS and fatigue in OSA patients: Update Winfried Randerath (Germany) 12:52pm – 1:12pm rEDS in CPAP treated patients Jean Louis Pépin (France) 1:12pm – 1:32pm OSA patients without primary therapy: What to do Maria Rosaria Bonsignore (Italy) 1:32pm – 1:52pm Pharmacological treatments: A network meta-analysis Christian Caussé (France) 1:52pm – 2:00pm Question and answer

NOX MEDICAL: BEYOND THE AHI

MANAGEMENT USING PATIENT-REPORTED OUTCOME MEASUREMENTS 12:30pm – 2:00pm | Room 23 Chairs: Kimberly Sterling (United States); Anita Simonds (United Kingdom) 12:30pm – 12:35pm Introduction Kimberly Sterling (United States); Anita Simonds (United Kingdom) 12:35pm – 1:00pm Validated PROM tools in sleep apnoea and their readiness for implementation at scale Inger Abma (Netherlands) 1:00pm – 1:25pm Influence of PROM on positive airway pressure treatment adherence in obstructive sleep apnoea Peter Cistulli (Australia) 1:25pm – 1:50pm Impact of an out-of-hospital virtual sleep unit on clinical outcomes Ulla Anttalainen (Finland)

12:30pm – 2:00pm | Room 22 Chair: Carolina Lombardi (Italy) 12:30pm – 12:40pm Welcome and introduction Carolina Lombardi (Italy)

1:50pm – 2:00pm Question and answer

12:40pm – 1:00pm Self-Applied Somnography - next generation of sleep studies?

Christoph Schöbel (Germany); Martina Sundrup Große (Germany) 1:00pm – 1:20 The Sleep Revolution Erna Sif Arnardóttir (Iceland)

MON

MARCH 14

ACTIVINSIGHTS: BEYOND ACTIGRAPHY: ACCELEROMETRY AND SLEEP BIOMARKERS FROM WEARABLES 1:00pm - 1:45pm | Room 32 Chair: Joss Langford (United Kingdom)

93 | Scientific Program | WORLD SLEEP 2022

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MARCH 11

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MARCH 12

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MARCH 13

K08 | COLIN ESPIE: DELIVERING CLINICAL GUIDELINE CARE FOR INSOMNIA: THE POTENTIAL OF DIGITAL THERAPEUTICS TO CLOSE THE TREATMENT GAP

2:00pm – 2:02pm Introduction Sharon Keenan (United States) 2:02pm – 2:45pm Keynote Presentation Colin Espie (United Kingdom)

K09 | ALEX IRANZO: THE ISOLATED FORM OF REM SLEEP BEHAVIOR DISORDER AS AN OPPORTUNITY FOR A NEUROPROTECTIVE INTERVENTION 2:00pm – 2:45pm | Room 14

2:02pm – 2:45pm Keynote Presentation Alex Iranzo (Spain)

K10 | AMITA SEHGAL: WHY WE NEED TO SLEEP: INSIGHTS FROM A SMALL ANIMAL MODEL

2:02pm – 2:45pm Keynote Presentation Amita Sehgal (United States)

MARCH 15

WED

MARCH 16

S43: SLEEPING IN SPACE: FUTURE FRONTIERS 3:00pm – 4:30pm | Room 11 Chair: Laura Flynn-Evans (United States)

3:02pm – 3:18pm Factors influencing sleep disruption in space: From environmental disruption to circadian misalignment Erin Flynn-Evans (United States) 3:18pm – 3:34pm Sleeping in space and neuroplasticity Ivana Rosenzweig (United Kingdom) 3:34pm – 3:50pm What can we learn about sleep in space from space analogs?

Cassie Hilditch (United States) 3:50pm – 4:06pm A roadmap towards machine learning approach for sleep quality assessment in space?

Christos Frantzidis (Greece)

2:00pm – 2:02pm Introduction Birgit Högl (Austria)

2:00pm – 2:02pm Introduction Phyllis Zee (United States)

TUES

3:00pm – 3:02pm Introduction

2:00pm – 2:45pm | Room 11

2:00pm – 2:45pm | Room 24

MON

MARCH 14

4:06pm – 4:22pm Changes in sleep architecture during long-term spaceflight Oliver Piltch (United States) 4:22pm – 4:30pm Question and answer

S44: IMPROVING SLEEP USING CONSUMER SLEEP TECHNOLOGY 3:00pm – 4:30pm | Room 13 Chairs: Kelly Baron (United States); Thomas Penzel (Germany) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm The future of sleep health technology for populationlevel sleep health Michael Grandner (United States)

94 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

SAT

SUN

MARCH 12

MARCH 13

3:22pm – 3:42pm Population trends and intervention phenotyping with consumer sleep trackers Thomas Penzel (Germany) 3:42pm – 4:02pm Technology assisted behavioural sleep interventions: possibilities and pitfalls Kelly Baron (United States) 4:02pm – 4:22pm American Life in Realtime (ALiR): Person-generated health data from Fitbits to assess the multi-level influence of social determinants on sleep and other health outcomes in vulnerable and underserved populations Ritika Chaturvedi (United States)

TUES

MARCH 15

WED

MARCH 16

S45: THE USE OF META-ANALYSES IN SLEEP RESEARCH 3:00pm – 4:30pm | Room 21 Chair: Gabriel Pires (Brazil) 3:00pm – 3:02pm Introduction 3:02pm – 3:18pm An overview on the use of meta-analysis in sleep research Gabriel Pires (Brazil) 3:18pm – 3:34pm Meta-analyses about sleep and mental health Amparo Díaz-Román (Spain) 3:34pm – 3:50pm Meta-analyses about insomnia Dieter Riemann (Germany)

4:22pm – 4:30pm Question and answer

DS2: ISRTP MENTEES’ PERSPECTIVES ON OBSTRUCTIVE SLEEP APNEA THROUGHOUT THE WORLD 3:00pm – 4:30pm | Room 15 Chair: Arezu Najafi (Iran)

3:50pm – 4:06pm Sleep apnea, CPAP and cardiovascular outcomes: Using meta-analyses to bring new evidence Luciano Drager (Brazil) 4:06pm – 4:22pm Meta-analyses in dental sleep medicine Giulio Alessandri-Bonetti (Italy)

3:00pm – 3:02pm Introduction 3:02pm – 3:22pm Prevalence of obstructive sleep apnea in Iran: A population-based study Arezu Najafi (Iran) 3:22pm – 3:42pm Relationships of atherosclerosis and OSA Soriul Kim (Korea, Republic of) 3:42pm – 4:02pm Association between obstructive sleep apnea with inflammation related variants and protein levels Yuan Zhang (China) 4:02pm – 4:22pm The effect of armodafinil on sleep spindles in obstructive sleep apnea Leila Emami (Iran) 4:22pm – 4:30pm Question and answer

MON

MARCH 14

4:22pm – 4:30pm Question and answer

S46: RESTLESS SLEEP DISORDER (RSD), DISENTANGLING A NEWLY DEFINED MOVEMENT DISORDER FROM OTHER PEDIATRIC SLEEP DISORDERS 3:00pm – 4:30pm | Room 22 Chair: Raffaele Ferri (Italy) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm Intro on restless sleep disorder (state of the art) Lourdes DelRosso (United States) 3:22pm – 3:42pm Detecting and scoring restless sleep disorder Raffaele Ferri (Italy)

95 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

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MARCH 12

SUN

MARCH 13

MON

MARCH 14

TUES

MARCH 15

3:42pm – 4:02pm Restless sleep disorder vs. restless legs syndrome Daniel Picchietti (United States)

S48: DREAMING AND MEMORY

4:02pm – 4:22pm Restless Sleep Disorder vs. NREM sleep parasonnia Derya Karadeniz (Turkey)

3:00pm – 4:30pm | Room 24 Chair: Martin Dresler (Netherlands)

WED

MARCH 16

CONSOLIDATION: METHODOLOGICAL ISSUES AND NOVEL EVIDENCE

3:00pm – 3:02pm Introduction

4:22pm – 4:30pm Question and answer

S47: ASSEMBLY OF THE NATIONAL SLEEP SOCIETIES: TELEMEDICINE IN SOMNOLOGY 3:00pm – 4:30pm | Room 23 Chair: Johan Verbraecken (Belgium) 3:00pm – 3:02pm Introduction 3:02pm – 3:18pm Telemedicine in somnology: an overview Johan Verbraecken (Belgium) 3:18pm – 3:34pm The current situation with sleep-related telemedicine in Europe: ANSS survey results Oana-Claudia Deleanu (Romania) 3:34pm – 3:50pm Sleep telemedicine in germany: A developed model Peter Young (Germany)

3:02pm – 3:22pm How dreams of the past may prepare us for the future Erin Wamsley (United States) 3:22pm – 3:42pm Investigating the relationship between dreams and memories: Old problems and new solutions Giulio Bernardi (Italy) 3:42pm – 4:02pm Differential roles of NREM and REM dreams for memory consolidation during sleep Sarah Schoch (Netherlands) 4:02pm – 4:22pm Memory sources in dreams across time and sleep stages: Relationship with procedural learning and implication for dream research Claudia Picard-Deland (Canada) 4:22pm – 4:30pm Question and answer

3:50 – 4:06pm Telemedicine in pediatrics somnology Barbara Stražišar (Slovenia)

O22: AGING AND DEVELOPMENTAL ISSUES

4:06pm – 4:22pm Teleservices in translational sleep research: Current state and prospects Ysbrand D. van der Werf (Netherlands)

3:00pm – 3:15pm Trajectories of sleep duration and timing prior to dementia: a 14-year follow-up study Clémence Cavaillès (France)

4:22pm – 4:30pm Question and answer

3:15pm – 3:30pm The interplay between sleep, cognition and copy number variations Rackeb Tesfaye (Canada)

3:00pm – 4:30pm | Room 32

3:30pm – 3:45pm Insomnia disorder predicts self-reported cognitive decline in middle-aged and older adults Nathan Cross (Canada) 96 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

SAT

SUN

MARCH 12

MARCH 13

3:45pm – 4:00pm Behavioral and Lifestyle Correlates of Sleep in an Older Adult Population: Results from the Canadian Longitudinal Study on Aging Saverio Stranges (Canada)

O23: INSOMNIA AND TREATMENT 3:00pm – 4:30pm | Room 33 3:00pm – 3:15pm Comparing Face-to-Face Cognitive Behavioral Therapy with Digitalized Cognitive Behavioral Therapy for Insomnia: A Network Meta-Analysis Laura Simon (Germany) 3:15pm – 3:30pm Cognitive-behavioral therapy for insomnia reduces sleep duration misperception in chronic insomnia Aurore A. Perrault (Canada) 3:30pm – 3:45pm Effects of digital cognitive behavioral therapy for insomnia in a diverse sample: Results from a randomized controlled trial Leonie Maurer (Germany) 3:45pm – 4:00pm An RCT of an Internet Intervention for Insomnia Tailored for Older Adults (SHUTi-OASIS) Lee Ritterband (United States) 4:00pm – 4:15pm Real world efficacy of a multicomponent CBTi program with chatbot and AI Laura S Castro (Brazil)

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

S49: THE IMPACT OF SLEEP ON THE IMMUNE SYSTEM: IMPLICATIONS FOR UNRESOLVING POST INFECTION SYMPTOMS 4:45pm – 6:15pm | Room 11 Chair: Monika Haack (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Sleep and respiratory infections John Axelsson (Sweden) 5:07pm – 5:27pm Sleep effects on recognition, response, recruitment, regulation and resolution in (auto)immunity Tanja Lange (Germany) 5:27pm – 5:47pm The impact of prolonged sleep disturbances and recovery on inflammatory balance, pain and fatigue Monika Haack (United States) 5:47pm – 6:07pm Cognitive behavioral therapy for insomnia: Implications for immune function and long COVID Norah Simpson (United States) 6:07pm – 6:15pm Question and answer

S50: SLEEP AND CARDIOVASCULAR DISEASE – AN EMERGING INVESTIGATOR SYMPOSIUM 4:45pm – 6:15pm | Room 13 Chairs: Virend Somers (United States); Nicola Montano (Italy)

ISRTP: RESEARCH PROJECTS AND COLLABORATION OPPORTUNITIES

4:45pm – 4:47pm Introduction

4:30pm - 6:00pm | Room 33 Chair: Mike Mutschelknaus (United States); Clete Kushida (United States)

4:47pm – 5:07pm The interplay between sleep, the autonomic nervous system and inflammation: Emerging evidence and clinical implications Eleonora Tobaldini (Italy) 5:07pm – 5:27pm Insufficient sleep and obesity risk: insights from experimental sleep restriction models Naima Covassin (United States)

97 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

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MARCH 12

SUN

MARCH 13

5:27pm – 5:47pm Insomnia and incident cardiovascular disease Sogol Javaheri (United States) 5:47pm – 6:07pm Sleep apnea and aortic dissection Jiang Xie (China) 6:07pm – 6:15pm Question and answer

S51: ADVANCES IN SLEEP IN WOMEN OF REPRODUCTIVE AGE

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

S52: MECHANISMS OF THE INSOMNIASUICIDALITY ASSOCIATION 4:45pm – 6:15pm | Room 15 Chair: Daniel Kay (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm Understanding the role of sleep disturbance in suicidal pathways Donna Littlewood (United Kingdom) 5:03pm – 5:19pm Insomnia, hyperarousal, executive function, and suicide risk factors Vaughn McCall (United States)

4:45pm – 6:15pm | Room 14 Chair: Helena Hachul (Brazil) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm Sleep across the menstrual cycle in healthy women Fiona Baker (United States) 5:03pm – 5:19pm Hormonal contraception and sleep Andréia Bezerra (Brazil) 5:19pm – 5:35pm Sleep during pregnancy and in postpartum Päivi Polo-Kantola (Finland)

5:19pm – 5:35pm Nocturnal wakefulness as a suicide risk factor Michael Grandner (United States) 5:35pm – 5:51pm Sleep disturbance and suicidal risk in adolescents Laura Palagini (Italy) 5:51pm – 6:07pm The effect of CBT for insomnia on suicidal thoughts and behaviors Wilfred Pigeon (United States)

5:35pm – 5:51pm Sleep disorders in women Luigi Ferini-Strambi (Italy)

6:07pm – 6:15pm Question and answer

5:51pm – 6:07pm Social aspects of sleep among women Helena Hachul (Brazil)

AND THE BODY IN SLEEPWALKING, SLEEP TERRORS AND CONFUSIONAL AROUSALS IN ADULTHOOD

6:07pm – 6:15pm Question and answer

S53: AWAKE OR ASLEEP? THE MIND, THE BRAIN

4:45pm – 6:15pm | Room 21 Chairs: Claudio Bassetti (Switzerland); Lino Nobili (Italy) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm New insights into motor patterns in disorders of arousal Giuseppe Loddo (Italy)

98 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

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MARCH 12

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MARCH 13

5:03pm – 5:19pm Contribution of brain circuits in disorders of arousal episodes Anna Castelnovo (Switzerland) 5:19pm – 5:35pm Disorders of arousal as a disorder of sleep state dissociation Lino Nobili (Italy) 5:35pm – 5:51pm Dreamlike mentation during sleepwalking and sleep terrors in adult Isabelle Arnulf (France) 5:51pm – 6:07pm Regional spectral signatures of dreaming in DoA Jacinthe Cataldi (Switzerland)

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

5:51pm – 6:07pm Orthodontic evaluation and treatment in pediatric OSA Francesca Milano (Italy) 6:07pm – 6:15pm Question and answer

S55: UNRAVELLING THE HIDDEN MYSTERY OF SLEEP QUALITY: HOW CAN ODDS RATIO PRODUCT (ORP) HELP? 4:45pm – 6:15pm | Room 23 Chair: Amy Bender (Canada) 4:45pm – 4:50pm Introduction of speakers Amy Bender (Canada) 4:50pm – 5:00pm ORP: What is it and how can it be used in clinical practice?

Diane Lim (United States)

6:07pm – 6:15pm Question and answer

S54: ENDOTYPING BASED APPROACH TO PEDIATRIC OSA 4:45pm – 6:15pm | Room 22 Chair: Karen Spruyt (France) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm A Physiological insight into endotypes and pharyngeal airway dynamics in pediatric OSA Venkat Koka (France) 5:03pm – 5:19pm Present and Future treatments in Pediatric OSA Umakanth Katwa (United States)

5:00pm – 5:11pm CPAP adherence: Can we identify at-risk patients up front, so the machine doesn’t collect dust?

Magdy Younes (Canada) 5:11pm – 5:31pm Does differences in ORP explain symptom subtypes of Obstructive Sleep Apnea?

Allan I Pack (United States) 5:31pm – 5:51pm Sleep quality and sleepiness with ORP: The long, lost, missing link Danny Eckert (Australia) 5:51pm – 6:15pm Panel discussion

5:19pm – 5:35pm Role of Drug Induced Sleep Endoscopy in Pediatric OSA Andrea DeVito (Italy) 5:35pm – 5:51pm Orofacial myofunctional therapy and breathing retraining in pediatric OSA Rosalba Courtney (Australia)

99 | Scientific Program | WORLD SLEEP 2022

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MARCH 11

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MARCH 12

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MARCH 13

S56: THE EFFECTS OF LIGHT ON SLEEP AND SLEEPINESS IN ECOLOGICAL SETTINGS 4:45pm – 6:15pm | Room 24 Chair: Nayantara Santhi (United Kingdom) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm The Effect of Outdoor and Indoor Light Exposure on Sleep and Sleepiness Tamar Shochat (Israel) 5:03pm – 5:19pm Individual exposure and sensitivity to light as sources of irregular sleep/wake patterns Dorothee Fischer (Germany) 5:19pm – 5:35pm Light to make you sleep better or feel better? Experiences from a randomized controlled trial in nursing home patients with severe dementia Elisabeth Flo-Groeneboom (Norway) 5:35pm – 5:51pm Ambulatory circadian monitoring: A tool for personalised sleep and circadian recommendations María-Ángeles Bonmatí-Carrión (Spain) 5:51pm – 6:07pm Towards FAIR (findable, accessible, interoperable and reusable) data in chronobiology and sleep research Manuel Spitschan (United Kingdom) 6:07pm – 6:15pm Question and answer

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

5:00pm – 5:15pm Ertugliflozin and Incident Obstructive Sleep Apnea: An Analysis from the VERTIS CV Trial Brian S. Wojeck (United States) 5:15pm – 5:30pm Trajectories of residual apnea-hypopnea index associated with mask changes in continuous positive airway pressure-treated obstructive sleep apnea patients Alphanie Midelet (Grenoble, France)

O25: NEUROPHYSIOLOGICAL ASPECTS IN RBD 4:45pm – 6:15pm | Room 32 4:45pm – 5:00pm Brain-clinical perfusion patterns may predict conversion subtype in REM sleep behavior disorder Shady Rahayel (Canada) 5:00pm – 5:15pm Percentage tonic REM sleep is most predictive of phenoconversion to neurodegenerative disease in iRBD Ankur Singh (United Kingdom) 5:15pm – 5:30pm Computerized analysis of muscular activity in the flexor digitorum superficialis muscles as screening tool for REM sleep without atonia Matteo Cesari (Austria) 5:30pm – 5:45pm Alterations of the human k-complexes during nrem sleep in isolated rem sleep behavior disorder Maurizio Gorgoni (Italy)

O24: SLEEP DISORDERED BREATHING: MODELING AND OTHER INTERVENTIONS

5:45pm – 6:00pm Electrocortical overlap between isolated RBD and Parkinson’s disease with RBD: a pilot TMS study Giuseppe Lanza (Italy)

4:45pm – 6:15pm | Room 31

POSTER ABSTRACT:

4:45pm – 5:00pm Insulin resistance, obstructive sleep apnea phenotypes, and response to CPAP treatment in adults with coronary artery disease Yeliz Celik (Turkey)

GROUP A 5:30pm – 6:15pm | Poster Hall

POSTER ABSTRACT: GROUP B 6:15pm - 7:00pm | Poster Hall

100 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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FRI

MARCH 11

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MARCH 12

SUN

MARCH 13

WORLD SLEEP ACADEMY: A NEW TRAINING PROGRAM FROM THE WORLD SLEEP SOCIETY 7:30am – 7:55am | Room 31 Chairs: Mike Mutschelknaus (United States); Lindsay Jesteadt (United States)

K11 | THOMAS SCAMMELL: NARCOLEPSY: FROM BASIC SCIENCES TO THERAPEUTIC APPROACHES 8:00am – 8:45am | Room 11 8:00am – 8:02am Introduction Clete Kushida (United States)

MON

MARCH 14

TUES

MARCH 15

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MARCH 16

9:22am – 9:42am Artificial intelligence in sleep medicine: Where are we standing?

Emmanuel Mignot (United States) 9:42am – 10:02am Wearable sleep technologies: How artificial intelligence is changing at-home sleep tracking Thomas Penzel (Germany) 10:02am – 10:22am Towards integration of artificial intelligence in clinical sleep practice: A road map for the future Cathy Goldstein (United States) 10:22am – 10:30am Question and answer

8:02am – 8:45am Keynote Presentation Thomas Scammell (United States)

S58: THE CHICKEN AND THE EGG OF TREATING

K12 | TRACEY SLETTEN: SLEEP, SHIFT WORK,

9:00am – 10:30am | Room 13 Chair: Daniel Taylor (United States)

AND OCCUPATIONAL HEALTH: IMPLICATIONS AND INTERVENTIONS 8:00am – 8:45am | Room 24 8:00am – 8:02am Introduction Elizabeth Klerman (United States) 8:02am – 8:45am Keynote Presentation Tracy Sletten (Australia)

S57: ARTIFICIAL INTELLIGENCE IN SLEEP MEDICINE: METHODS, STATE-OF-THE-ART AND FUTURE DIRECTIONS FOR ITS INTEGRATION IN CLINICAL PRACTICE 9:00am – 10:30am | Room 11 Chair: Matteo Cesari (Austria) 9:00am – 9:02am Introduction 9:02am – 9:22am Artificial intelligence: A methodological overview Matteo Cesari (Austria)

SLEEP DISORDERS AND POSTTRAUMATIC STRESS DISORDER (PTSD)

9:00am – 9:02am Introduction 9:02am – 9:18am Cognitive behavioral therapy for insomnia in the context of COVID Jason Ellis (United Kingdom) 9:18am – 9:34am The impact of prolonged exposure on sleep and enhancing treatment outcomes with evidence-based sleep interventions: A pilot study Sean Drummond (Australia) 9:34am – 9:50am Sleep outcomes following written exposure therapy versus cognitive processing therapy for posttraumatic stress disorder in U.S. service members Hannah Tyler (United States) 9:50am – 10:06am Modular treatment of comorbid sleep disorders and complex PTSD Sofie Folke (United States)

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10:06am – 10:22am Treatment of comorbid insomnia, nightmares and posttraumatic stress disorder in active duty military: A pilot study Daniel Taylor (United States) 10:22am – 10:30am Question and answer

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ON DEMAND ONLY

S60: NEW INSIGHTS IN THE GATING OF SLEEP HOMEOSTASIS BY AROUSAL Chair: Michael Lazarus (Japan) Introduction

COGNITION, AND MOOD - NEW INSIGHTS IN ANIMAL MODELS AND HUMANS

Regulation of non-REM and REM sleep by the hypothalamic neurons Akihiro Yamanaka (Japan)

9:00am – 10:30am | Room 14 Chair: Jennifer Goldschmied (United States)

Wake-active neurons flip the sleep switch Henrik Bringmann (Germany)

9:00am – 9:02am Introduction

Long-range and local networks that regulate sleeppromoting ventrolateral preoptic neurons Elda Arrigoni (Italy)

S59: SLEEP, HOMEOSTATIC PLASTICITY,

9:02am – 9:18am Modulation of homeostatic plasticity as rapid antidepressant mechanism of acute sleep deprivation in mice Tsvetan Serchov (France) 9:18am – 9:34am Sleep- and time-dependent learning- and memory consolidation-related neurostructural changes Philippe Peigneux (Belgium) 9:34am – 9:50 am The neurochemistry of human sleep - insights form multimodal brain imaging and polysomnography Hans-Peter Landolt (Switzerland) 9:50am – 10:06am Modulation of Slow-wave Activity on Neuroplasticity and Mood in MDD Jennifer Goldschmied (United States) 10:06am – 10:22am Auditory closed-loop modulation of sleep slow waves to treat major depression Christoph Nissen (Switzerland) 10:22am – 10:30am Question and answer

Data-driven human sleep research draws the landscape of human sleep phenotypes Shoi Shi (Japan)

ON DEMAND ONLY

S61: SLEEP HEALTH: WHAT IT IS AND WHY IT IS IMPORTANT? Chairs: Bingqian Zhu (China); Bilgay Iczi-Balserak (United States) Introduction Validation of the sleep health index in a Chinese sample Bingqian Zhu (China) Associations between sleep health and other healthrelated variables in the UK Biobank Kai Spiegelhalder (Germany) Sleep health, cardiometabolic disease risk, and neurobehavioral function: Real-world implications Michael Grandner (United States) Cross-sectional and longitudinal associations of sleep health, depression and inflammation in the UK Biobank cohort Sandra Tamm (Sweden)

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S62: PHARMACOTHERAPY FOR PAEDIATRIC SLEEP DISORDERS; AN UPDATE ON THE SCIENTIFIC EVIDENCE AND BEST CLINICAL PRACTICES TO CONSIDER WHEN PROVIDING MEDICATION TO PAEDIATRIC PATIENTS 9:00am – 10:30am | Room 22 Chair: Shelly Weiss (Canada)

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9:22am – 9:42am RLS in patients with other sleep disorders Ambra Stefani (Austria) 9:42am – 10:02am RLS in patients with neurologic disease Anna Heidbreder (Austria)

9:00am – 9:02am Introduction

10:02am – 10:22am RLS in paediatric patients with psychiatric and neuropsychiatric diseases Lourdes DelRosso (United States)

9:02am – 9:22am Pharmacotherapy for children and adolescents with narcolepsy and other disorders of hyper somnolence Kiran Maski (United States)

10:22am – 10:30am Question and answer

9:22am – 9:42am Pharmacotherapy for pediatric insomnia in typically developing children: Is there a role?

Oliviero Bruni (Italy) 9:42am – 10:02am When behaviour strategies don’t work. The role of pharmacotherapy for children with ASD and other Neurodevelopmental disorders Beth Malow (United States) 10:02am – 10:22am Beyond pharmacotherapy; CBD and other ‘naturopathic cures’ for pediatric insomnia Shelly Weiss (Canada) 10:22am – 10:30am Question and answer

S63: RESTLESS LEGS SYNDROME ASSOCIATED WITH OTHER DISEASES: POTENTIAL MECHANISMS AND TREATMENT CONSIDERATIONS 9:00am – 10:30am | Room 23 Chair: Ambra Stefani (Austria)

S64: NEW MECHANISTIC INSIGHTS FROM IMAGING STUDIES INTO THE DIAGNOSIS AND TREATMENT OF OSA AND OHS 9:00am – 10:30am | Room 24 Chair: Richard Schwab (United States) 9:00am – 9:02am Introduction 9:02am – 9:18am Utility of ultrasound to evaluate the upper airway in adults with sleep apnea Richard Schwab (United States) 9:18am – 9:34am Understanding ethnic differences in upper airway anatomy in patients with sleep apnea Liyue Xu (China) 9:34am – 9:50am How does obesity cause sleep apnea - relationship to tongue fat Richard Schwab (United States)

9:00am – 9:02am Introduction

9:50am – 10:06am Using MRI to understand the mechanism of action of oral appliances and upper airway surgery Peter Cistulli (Australia)

9:02am – 9:22am RLS in patients with gastrointestinal and hepatobiliary disease Ravi Gupta (India)

10:06am – 10:22am What have we learned about obesity hypoventilation syndrome from imaging studies?

Chris Turnbull (United Kingdom)

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10:22am – 10:30am Question and answer

O27: SLEEP DISORDERED BREATHING IN CHILDREN: CONSEQUENCES AND TREATMENT

O26: SLEEP DISORDERED BREATHING: UPPER

9:00am – 10:30am | Room 32

AIRWAYS STRUCTURE AND FUNCTION 9:00am – 10:30am | Room 31 9:00am – 9:13am Ultrasound Backscatter Imaging for Upper Airway Tissue Composition Correlates with Obstructive Sleep Apnea Severity Stanley Liu (United States) 9:13am – 9:26am Quality of Life after Large Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea using a Single-Item Global Instrument Javier Howard (United States) 9:26am – 9:39am Changes in Tongue Morphology Predict Responses in Pharyngeal Patency to Selective Hypoglossal Nerve Stimulation Thomaz Fleury Curado (United States) 9:39am – 9:52am Identifying the site and pattern of pharyngeal collapse using polysomnographic airflow shapes Sara Op de Beeck (Belgium) 9:52am – 10:05am Pharyngeal site of collapse and collapsibility estimated from airflow predict oral appliance treatment efficacy Daniel Vena (United States) 10:05am – 10:18am Achieving Reduced Treatment Time for Obstructive Sleep Apnea Utilizing Surgery First Approach: A Comparison of Traditional versus Novel Techniques Nazlie Taheri (United States) 10:18am – 10:31am Charactering Airway Collapse from PSG Trained on Snoring Sound Chi-Wei Wu (Taiwan)

9:00am – 9:15am Mandibular Advancement with Vertical Ramus Osteotomies in an Infant: A Novel Technique for Addressing Airway Distress in Patients with Craniofacial Anomalies Kimiko Agari (United States) 9:15am – 9:30am Maxillomandibular Development After Mandibular Distraction Osteogenesis in Isolated Pierre Robin Sequence Patients Kimiko Agari (United States) 9:30am – 9:45am “Something is Wrong!”A Qualitative Study of Racial Disparities in Parental Experiences of OSA Detection in Their Child Alicia Chung (United States) 9:45am – 10:00am Comorbid Insomnia and Obstructive Sleep Apnea in School Age Children and Adolescents: a descriptive analysis with focus on polysomnographic data Miguel Meira e Cruz (Portugal) 10:00am – 10:15am Sleep disordered breathing since childhood associated with atherosclerosis in adulthood Julio Fernandez-Mendoza (United States) 10:15am – 10:30am Representation Learning for Anomaly Detection in Sleep Identifying Pediatric Mouth Breathing through Convolutional Autoencoders Luka Biedebach (Germany)

EXHIBIT HALL 9:30am – 2:00pm | Exhibit Hall

105 | Scientific Program | WORLD SLEEP 2022

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S65: HOW DOES CBT FOR INSOMNIA WORK? A SYMPOSIUM TO UNDERSTAND THE TREATMENT MECHANISMS 10:45am – 12:15pm | Room 11 Chair: Jaap Lancee (Netherlands) 10:45am – 10:47am Introduction 10:47am – 11:07am A network intervention analysis on the symptom specific effects of cognitive therapy and behavior therapy for insomnia Jaap Lancee (Netherlands) 11:07am – 11:27am The Mechanisms of Sleep Restriction Therapy for Insomnia: Results from a randomised-controlled trial Leonie Maurer (United Kingdom) 11:27am – 11:47am Sleep restriction and sleep compression: A direct randomized comparison Susanna Jernelöv (Sweden) 11:47am – 12:07pm Treating insomnia to prevent depression with therapistguided digital cognitive, behavioral and chronobiological interventions Joyce Reesen (Netherlands) 12:07pm – 12:15pm Question and answer

S66: GAINING INSIGHTS ABOUT OBSTRUCTIVE SLEEP APNOEA FROM LARGE-SCALE DATA 10:45am – 12:15pm | Room 13 Chair: Jean Louis Pépin (France)

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11:07am – 11:27am A Multinational Experience: The European Sleep Apnoea Database (ESADA) Jan Hedner (Sweden) 11:27am – 11:47am An International Perspective: The Sleep Apnea Global Interdisciplinary Consortium (SAGIC) Ulysses Magalang (United States) 11:47am – 12:07pm An Academic-Industry Partnership Perspective: MedXCloud Kimberly Sterling (United States) 12:07pm – 12:15pm Question and answer

S67: WHEN THE LOCUS COERULEUS SPEAKS UP DURING SLEEP - NOVEL INSIGHTS INTO THE ROLES OF NORADRENERGIC SIGNALING FOR SLEEP AND ITS DISORDERS 10:45am – 12:15pm | Room 14 Chair: Francesca Siclari (Switzerland) 10:45am – 10:47am Introduction 10:47am – 11:03am Activity in the locus coeruleus underlies sensory vigilance during NREM sleep in mouse Anita Luthi (Switzerland) 11:03am – 11:19am Memory behaving segments of sleep depend on the oscillatory amplitude of norepinephrine Celia Kjaerby (Denmark)

10:45am – 10:47am Introduction

11:19am – 11:35am Could feeling deeply asleep be related to noradrenergic quiescence?

Francesca Siclari (Switzerland)

10:47am – 11:07am The Power of Bridging Data from a National Registry and Nationwide Claims Database: The French Experience Jean Louis Pépin (France)

11:35am – 11:51am Does insufficient noradrenergic quiescence during REM-sleep maintain insomnia and mental disorders?

Eus van Someren (Netherlands) 11:51am – 11:59am Question and answer

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S69: IN SEARCH OF SYNAPTIC HOMEOSTASIS; EAT, SLEEP, MOVE, AT THE RIGHT TIME, WHILE BREATHING 10:45am – 12:15pm | Room 21 Chair: Sharon Keenan (United States)

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11:27am – 11:47am Consequences of insomnia and circadian sleep disorder on mental health during adolescence Chiara Baglioni (Italy and Germany) 11:47am – 12:07pm Management of insomnia in adolescence: From digital CBTi to meditation in the treatment of the disorder Eduard J. de Bruin (Netherlands)

10:45am – 10:47am Introduction 10:47am – 11:07am The Hypocretin/ Orexin System Thomas S. Kilduff (United States)

12:07pm – 12:15pm Question and answer

11:07am – 11:27am Optogenetics & the Discovery of Function for Hypocretin & Other Neuromodulators Luis de Lecea (United States)

COUNTRIES, PRIMARY STEPS AND CURRENT CHALLENGES

11:27am – 11:47am The Circadian System; Effects of food and activity Phyllis Zee (United States)

DS3: ESTABLISHING SLEEP LABS IN DEVELOPING

10:45am – 12:15pm | Room 23 Chair: Leila Emami (Iran) 10:45am – 10:47am Introduction

11:47am – 12:07pm Breathing Patrick McKeown (Ireland)

10:47am – 11:11am Establishment of sleep labs in developing countries Leila Emami (Iran)

12:07pm – 12:15pm Question and answer

11:11am – 11:35am Establishment of sleep labs in developing countries, first steps and current challenges Samson Khachatryan (Armenia)

S70: INSOMNIA IN ADOLESCENCE: NOVEL INSIGHTS ON ITS CLINICAL CHARACTERIZATION, IMPACT, AND MANAGEMENT 10:45am – 12:15pm | Room 15 Chairs: Massimiliano de Zambotti (United States); Laura Palagini (Italy) 10:45am – 10:47am Introduction

11:35am – 11:59am Establishing sleep labs in developing countries, primary steps and current challenges Hrudananda Mallick (India); Fang Han (China) 11:59am – 12:07pm Question and answer

10:47am – 11:07am Clinical characterization and diagnosis of insomnia in adolescence Fiona Baker (United States) 11:07am – 11:27am The development of insomnia in adolescence: Vulnerability & biobehavioral factors Julio Fernandez-Mendoza (United States) 107 | Scientific Program | WORLD SLEEP 2022

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S72: TOWARDS AN IMPROVED DIAGNOSTIC CLASSIFICATION OF CENTRAL DISORDERS OF HYPERSOMNOLENCE: HOW RECENT INSIGHTS GUIDE US TO NEW BIOMARKERS AND CUTOFFS 10:45am – 12:15pm | Room 24 Chair: Gert Jan Lammers (Netherlands) 10:45am – 10:47am Introduction 10:47am – 11:07am Diagnostic criteria for central disorders of hypersomnolence: A European perspective Gert Jan Lammers (Netherlands) 11:07am – 11:27am Diagnostic criteria for central disorders of hypersomnolence: An American perspective Kiran Maski (United States) 11:27am – 11:47am Machine learning in central disorders of hypersomnolence: A step towards data-driven phenotyping Jari Gool (Netherlands) 11:47am – 12:07pm Objective quantification of sleep duration in people with presumed increased need for sleep: A review of available techniques and protocols Yves Dauvilliers (France) 12:07pm – 12:15pm Question and answer

O28: INSOMNIA, COMOBORBIDITIES AND MECHANISMS 10:45am – 12:15pm | Room 31 10:45am – 11:00am Dissecting insomnia from sleep duration in relation to coronary artery disease: evidence from multivariableadjusted and factorial Mendelian Randomization analyses Raymond Noordam (Netherlands) 11:00am – 11:15am Structural brain differences in individuals with insomnia compared to good sleepers for volume, thickness, and shape Daniel Kay (United States)

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11:15am – 11:30am Association between insomnia phenotypes and subclinical myocardial injury: The Multi-Ethnic Study of Atherosclerosis Fjola D. Sigurdardottir (Norway) 11:30am – 11:45am The mediating role of neuro-immune markers in the long-term association between insomnia and depression: an eight-year follow-up Andrea Ballesio (Italy)

O29: CIRCADIAN MISALIGNMENT AND RISK FOR CARDIOMETABOLIC DISEASE AND PERFORMANCE 10:45am – 12:15pm | Room 32 10:45am – 11:00am Multi-omics based chronobiological signatures of health risks associated with night shift work Hans van Dongen (United States) 11:00am – 11:15am Setting your clock: Associations of physical activity timing with cardiovascular disease risk Gali Albalak (Netherlands) 11:15am – 11:30am The link between objective circadian phase, sleep and performance in elite athletes Elise R. Facer-Childs (Australia) 11:30am – 11:45am The cost of fast-rotating backward-shift work among nurses Valentina Alfonsi (Italy) 11:45am – 12:00pm Effects of sleep restriction and time of the day on balance control in healthy older men and women Ziad Shabana (United Kingdom) 12:00pm – 12:15pm Effect of night and shift work with metabolic syndrome and its components in an active middle-aged populationbased sample Mathieu Berger (Switzerland)

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12:15pm – 12:30pm Eveningness is associated with sedentary behavior and increased cardiovascular risk – data from the SCAPIS pilot cohort Mio Kobayashi Frisk (Gothenburg, Sweden)

ON DEMAND ONLY

S73: THE DIAGNOSTIC PHENOTYPING OF INSOMNIA: WHAT WENT WRONG IN THE PAST AND HOW WE MIGHT CORRECT IT Chair: Jack Edinger (United States) Introduction The failure of consensus based approaches for insomnia phenotyping: Facts and figures William Wohlgemuth (United States) Beyond sleep: effective prevention of depression by selecting and treating insomnia subtypes Tessa Blanken (Netherlands) Insomnia subtyping based on objective sleep duration: pathophysiology, morbidity and natural course Julio Fernandez-Mendoza (United States) Relationship between pre-treatment objective sleep duration and treatment outcome among insomnia patients with and without psychiatric comorbidity Jack Edinger (United States)

S74: AI FOR PRECISION MEDICINE IN SLEEP AND CIRCADIAN RHYTHMS

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12:30pm – 12:32pm Introduction 12:32pm – 12:48pm AI: What can and can’t it do for sleep medicine?

Cathy Goldstein (United States)

MARCH 16

1:04pm – 1:20pm Toward mathematical medicine: Development of drug and digital medicine for sleep disorders Jae Kyoung Kim (Korea, Republic of) 1:20pm – 1:36pm Individualized approaches for tracking circadian timing Julia Stone (Australia) 1:36pm – 1:52pm Mechanistic models meet machine learning: a hybrid approach, for sleep and circadian rhythms Olivia Walch (United States) 1:52pm – 2:00pm Question and answer

S76: HIGHLIGHTS OF CLINICAL AND BASIC PUBLICATIONS - BEST OF SLEEP MEDICINE 2020 - 2022 12:30pm – 2:00pm | Room 15 Chair: Winfried Randerath (Germany) 12:30pm – 12:32pm Introduction 12:32pm – 12:48pm Sleep Disordered Breathing Robert Thomas (United States) 12:48pm – 1:04pm Insomnia and Circardian Rythm Max Hirshkowitz (United States) 1:04pm – 1:20pm Pediatric Sleep Medicine Oliviero Bruni (Italy)

12:30pm – 2:00pm | Room 13 Chair: Amy Bender (Canada)

WED

1:20pm – 1:36pm Brain, Muscle and Sleep Luigi Ferini-Strambi (Italy)

12:48pm – 1:04pm Arousals and risk stratification in sleep apnea Ali Azarbarzin (United States)

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1:36pm – 1:52pm Movement Disorders Garima Shukla (Canada)

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NLS PHARMACEUTICS: QUILIENCE (MAZINDOL ER) A NEW APPROACH FOR TYPE I & TYPE II NARCOLEPSY: POLARIS CLINICAL DEVELOPMENT PROGRAM

1:52pm – 2:00pm Question and answer

S77: SLEEP AS A WINDOW TO THE MULTIFACTORIAL NATURE OF THE AGING PROCESS 12:30pm – 2:00pm | Room 21 Chairs: Tamar Shochat (Israel); Laura Palagini (Italy)

12:30pm – 2:00pm | Room 22 Chair: Michael Thorpy (United States) 12:30pm – 12:35pm Welcome Michael Thorpy (United States)

12:30pm – 12:32pm Introduction

12:35pm – 12:55pm Overview of current therapeutic options for Narcolepsy Michael Thorpy (United States)

12:32pm – 12:48pm Sleep duration, frailty, and mortality in later life: separating cause and consequence Kevin Morgan (United Kingdom)

12:55pm – 1:20pm Wake-promoting effects of Mazindol in orexin receptor 2 knockout mice Medhi Tafti (Switzerland)

12:48pm – 1:04pm Association between gut microbiota and sleep continuity and quality in older adults with insomnia Iris Haimov (Israel)

1:20pm – 1:30pm Quilience (Mazindol ER) for the treatment of Type I and Type II - Narcolepsy: Polaris Clinical Development program Bruce Corser (United States)

1:04pm – 1:20pm The link between glycemic markers and sleep among middle-aged adults Maayan Agmon (Israel) 1:20pm – 1:36pm Why do they fall? The impact of insomnia on gait of older adults Tamar Shochat (Israel) 1:36pm – 1:52pm Sleep reactivity, hyperarousal and emotion coping in different age groups Ellemarije Altena (France) 1:52pm – 2:00pm Question and answer

1:30pm – 1:50pm Quilience (mazindol ER) - Phase IIa - interim top-line results Bruce Corser (United States); Eric Konofal (France) 1:50pm – 2:00pm Panel discussion

S78: PREVENTION AND MANAGEMENT OF INFANT SLEEP PROBLEMS 12:30pm – 2:00pm | Room 23 Chair: Elizabeth Keys (Canada) 12:30pm – 12:32pm Introduction 12:32pm – 12:52pm The influence of parenting practices on infant sleepwaking behaviours in the first six months of age Barbara Potter (United Kingdom)

110 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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12:52pm – 1:12pm Behavior change components of interventions with a behavioral sleep outcome for infants: A systematic review using the Behavior Change Wheel Elizabeth Keys (Canada) 1:12pm – 1:32pm Infant sleep outcomes associated with cognitive behavioral therapy for insomnia during pregnancy and the COVID-19 pandemic Anna L. Mackinnon (Canada) 1:32pm – 1:52pm Implementing evidence-based information and strategies in practice Maggie Fisher (United Kingdom) 1:52pm – 2:00pm Question and answer

S79: SLEEP DEPRIVATION EXAMINED: INSIGHTS FROM A CENTURY AGO AS WELL AS CONTEMPORARY STUDIES 12:30pm – 2:00pm | Room 24 Chair: Joel Dimsdale (United States) 12:30pm – 12:32pm Introduction 12:32pm – 12:52pm A treacherous history: the history of sleep deprivation and coercive persuasion Joel Dimsdale (United States) 12:52pm – 1:12pm Impact of various types of sleep loss on specific components of decision making Sean Drummond (Australia) 1:12pm – 1:32pm Impact of sleep deprivation on cognitive flexibility and emotional control Hans van Dongen (United States)

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O30: SLEEP HEALTH DURING THE COVID-19 PANDEMIC 12:30pm – 2:00pm | Room 31 12:30pm – 12:43pm COVID-19-Related Sleep Quality, Stress, Health Behaviors and Mental Health Symptoms among Israeli and U.S. Adults Orna Tzischinsky (Israel) 12:43pm – 12:56pm Changes in Sleep Before and During COVID-19 in Urban American Indian/Alaska Native Adolescents Wendy Troxel (United States) 12:56pm – 1:09pm Well-Being Therapy as Adjunctive to Sleep Hygiene Improves Sleep and Well-Being in Adults With Poor Sleep and Distress During the COVID-19 Pandemic: A Pilot Randomized Controlled Study Giada Benasi (United States) 1:09pm – 1:22pm Insomnia and nightmare profiles during the COVID-19 pandemic in Portugal: characterization and associated factors Marta Gonçalves (Portugal) 1:22pm – 1:35pm Impact of sleep duration on the response to vaccination: A meta-analysis Karine Spiegel (France) 1:35pm – 1:48pm Tackling Long COVID using international host genetics research collaboration Vilma Lammi (Finland) 1:48pm – 2:01pm A Comparison of Estimated Sleep-Wake Patterns Obtained from a Large U.S. Sample by Home-Based Under-Mattress Monitoring Devices Before and After the Start of the COVID-19 Pandemic Clete Kushida (United States)

1:32pm – 1:52pm Sleep deprivation in Athletes: Impacts on Exercise Performance Atul Malhotra (United States) 1:52pm – 2:00pm Question and answer 111 | Scientific Program | WORLD SLEEP 2022

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O31: NARCOLEPSY 12:30pm – 2:00pm | Room 32 12:30pm – 12:45pm Development and Validation of the Pediatric Hypersomnia Survey (PHS) Kiran Maski (United States) 12:45pm – 1:00pm Linking clinical complaints and objective measures of Disrupted Nighttime Sleep in Narcolepsy type 1 Lucie Barateau (France) 1:00pm – 1:15pm Epigenetic regulation of orexin neurons by miRNAs Marie-Laure Possovre (Switzerland) 1:15pm – 1:30pm Unsupervised clustering of central hypersomnolence disorders enables data-driven phenotyping: toward more reliable diagnostic criteria Jari Gool (Netherlands) 1:30pm – 1:45pm Novel genes associated with hypocretin-producing neurons identified by gene expression profiling Mink Schinkelshoek (Netherlands)

T04: TRAINING, EDUCATION AND SKILLS IN THE ITALIAN SLEEP LABS: COMPARISON WITH ESST EXPERIENCE 12:30pm – 2:00pm | Room 33 Chair: Paolo Matrigiani (Italy) 12:30pm – 12:32pm Introduction Paolo Matrigiani (Italy) 12:32pm – 12:52pm Becoming a Sleep technologist in Italy: A walkthrough Battista Di Gioia (Italy) 12:52pm – 1:12pm The role of the sleep tech in scientific research: An Italian perspective Federica Testa (Italy)

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1:12pm – 1:32pm The importance of social communication: Our role a correct approach to the patients Paolo Matrigiani (Italy) 1:32pm – 1:52pm Advanced qualifications for sleep technologists in the UK, Europe and beyond Elizabeth (Lizzie) Hill (United Kingdom) 1:52pm – 2:00pm Question and answer

K13 | DANNY ECKERT: SLEEP APNEA ENDOTYPES AND IMPLICATIONS FOR PRECISION SLEEP MEDICINE 2:00pm – 2:45pm | Room 11 2:02pm – 2:45pm Introduction Andrew Wellman (United States) 2:02pm – 2:45pm Keynote Presentation Danny Eckert (Australia)

K14 | DANIEL J. BUYSSE: MULTIDIMENSIONAL SLEEP HEALTH: MEASUREMENT, CONSEQUENCES AND INTERVENTIONS 2:00pm – 2:45pm | Room 24 2:02pm – 2:45pm Introduction Colin Espie (United Kingdom) 2:02pm – 2:45pm Keynote Presentation Daniel J. Buysse (United States)

WORLD SLEEP SOCIETY: A GLOBAL SLEEP HEALTH: STRATEGIC PLANNING SESSION FOR WORLD SLEEP SOCIETY’S NEW INITIATIVE 3:00pm - 6:00pm | Room 11 Chair: Phyllis Zee (United States)

112 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

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S81: EMERGING SLEEP APNEA RESEARCH FINDINGS FROM YOUNG INVESTIGATORS IN AN INTERNATIONAL COLLABORATION 3:00pm – 4:30pm | Room 13 Chair: Allan Pack (United States)

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4:02pm – 4:22pm GABAergic mechanism of the substantia nigra pars reticulata and RLS Yuan-Yang Lai (United States) 4:22pm – 4:30pm Question and answer

3:00pm – 3:10pm What is the sleep apnea global interdisciplinary consortium (SAGIC)?

Allan I Pack (United States) 3:10pm – 3:30pm Heart rate variability during wakefulness as a marker of OSA severity Hua Qin (China) 3:30pm – 3:50pm Ethnic differences in structural risk factors for OSA Diane Lim (United States) 3:50pm – 4:10pm OSA case identification strategy based on machine learning using EHR data Steven Holfinger (United States) 4:10pm – 4:26pm Are participants of randomised trials of CPAP representative of sleep clinic patients?

Ayesha Reynor (Australia)

S82: NEUROANATOMICAL ASPECTS OF RESTLESS LEGS SYNDROME – FROM CORTEX TO SPINAL CORD 3:00pm – 4:30pm | Room 14 Chair: Yuan-Yang Lai (United States) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm Comparing animal models of RLS: dopamine D3KO, Meis1KO, and brain iron deficient mice Stefan Clemens (United States) 3:22pm – 3:42pm Putative Glutamatergic Mechanisms Involved in the Pathology of Restless Legs Syndrome Christopher Earley (United States) 3:42pm – 4:02pm Dipyridamole in the treatment of RLS Diego Garcia-Borreguero (Spain)

MON

S83: WEARABLE TECHNOLOGY IN SLEEP MEDICINE: STATE-OF-ART OF CURRENT CLINICAL APPLICATIONS IN PEOPLE WITH SLEEP AND CIRCADIAN RHYTHM DISORDERS 3:00pm – 4:30pm | Room 15 Chair: Marco Filardi (Italy) 3:00pm – 3:02pm Introduction 3:02pm – 3:15pm Wearable devices: a tool for the screening, follow-up and ecologically monitor of patients with central disorders of hypersomnolence Marco Filardi (Italy) 3:15pm – 3:28pm Putting actigraphy to bed in insomnia Christopher Gordon (Australia) 3:28pm – 3:41pm Wearable devices in REM sleep behavior disorder: current use and future potential Ambra Stefani (Austria) 3:41pm – 3:54pm Wearables and distorted clocks: Leveraging new technologies for the assessment and treatment of circadian rhythm sleep-wake disorders Rebecca Robillard (Canada) 3:54pm – 4:07pm Consumer sleep wearable technology: rationale, performance, and role in research and clinical sleep medicine Massimiliano de Zambotti (United States) 4:07pm – 4:20pm Cicada: an open access wearable data analysis software Rick Wassing (Australia) 4:20pm – 4:28pm Question and answer

113 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

S84: EXTRACTING MEANING FROM SLEEP AND CIRCADIAN DATA: NEW AND EMERGING TOOLS AND APPROACHES 3:00pm – 4:30pm | Room 21 Chair: Anne Skeldon (United Kingdom) 3:00pm – 3:02pm Introduction 3:02pm – 3:22pm Using genetic variants to investigate the causal nature of sleep traits on chronic disease risk: a Mendelian randomization approach James Liu (United Kingdom) 3:22pm – 3:42pm Mathematical models for circadian phase prediction Julia Stone (Australia) 3:42pm – 4:02pm Quantification of sleep patterns from large scale wearable data - opportunities and challenges Eva Winnebeck (Germany) 4:02pm – 4:22pm Sleep homeostasis, circadian rhythmicity, light and social constraints: developing predictive personalised models Anne Skeldon (United Kingdom) 4:22pm – 4:30pm Question and answer

S85: THE PROMISE OF BIG DATA: AUTOVIDEOSOMNOGRAPHY AS A NEW TOOL FOR PEDIATRIC SLEEP RESEARCH AND SLEEP MEDICINE 3:00pm – 4:30pm | Room 22 Chair: Thomas Anders (United States); Natalie Barnett (United States) 3:00pm – 3:02pm Introduction 3:02pm – 3:18pm The impact of COVID-19 on infant sleep and screen time, and on parental sleep and well-being: evidence from auto-videosomnography and parent-reports Michael Gradisar (Australia)

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

3:18pm – 3:34pm Exploring the effect of parental cognitions on baby’s and parent’s sleep using auto-vidosomnography Sooyeon Suh (Korea, Republic of) 3:34pm – 3:50pm The use of auto-videosomnography to examine the relation between activity and movement during sleep and motor development in infancy Sarah Berger (United States) 3:50pm – 4:06pm All you need is sleep? Objectively measured infant sleep and its associations with parent sleep, sexual activity, and relationship satisfaction Michal Kahn (Australia) 4:06pm – 4:22pm Using auto-videosomnography to examine between and within racial/ethnic group differences in the multiple dimensions of early childhood sleep health Monica Ordway (United States) 4:22pm – 4:30pm Question and answer

O32: YOUNG INVESTIGATOR AWARD 3:00pm – 4:30pm | Room 23 3:00pm – 3:15pm Epigenetic clocks suggest accelerated ageing in isolated REM Sleep Behavior Disorder patients Luca Baldelli (Italy) 3:15pm – 3:30pm Hypocretin Release and Plasticity of Hypocretinergic Receptors in a Pharmacological Model with Narcolepsylike Features Induced by Suvorexant in Rats Carlos Carrera-Cañas (Madrid, Spain) 3:30pm – 3:45pm Interactions between sleep and gut bacteria in healthy developing infants Sarah Schoch (Netherlands) 3:45pm – 4:00pm Desaturation severity affects OSA-related changes in short-term heart rate variability Salla Hietakoste (Kuopio, Finland)

114 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

4:00pm – 4:15pm Longitudinal associations of insufficient sleep duration and insomnia with obesity from adolescence to young adulthood in the GINIplus and LISA studies Mingming Wang (Germany)

S80: BETTER SLEEP IN PSYCHIATRY: NEW AVENUES IN CBT-I 3:00pm – 4:30pm | Room 24 Chair: Bjørn Bjorvatn (Norway) 3:00pm – 3:02pm Introduction 3:02pm – 3:17pm Better Sleep in Psychiatry – a project to improve sleep and reduce hypnotics use in psychiatric patients in the Stockholm Region, Sweden Susanna Jernelöv (Sweden) 3:17pm – 3:32pm Become your own SLEEPexpert: a behavioral treatment program for insomnia in patients with psychiatric disorders Christoph Nissen (Switzerland) 3:32pm – 3:47pm Combined insomnia and depression treatment via the internet for patients with both diagnoses Kerstin Blom (Sweden) 3:47pm – 4:02pm Evening light environment and chronotherapeutic effects on individuals in a psychiatric ward Håvard Kallestad (Norway) 4:02pm – 4:30pm Question and answer

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

O33: SLEEP DISORDERED BREATHING: NEW DIAGNOSTIC AND TREATMENT STRATEGIES 3:00pm – 4:30pm | Room 31 3:00pm – 3:15pm Mandibular movements are a reliable noninvasive alternative to esophageal pressure for measuring respiratory effort in patients with sleep apnea syndrome Jean-Benoit Martinot (Belgium) 3:15pm – 3:30pm Development of a Novel Intra-oral Sensor System for Monitoring Nightly Efficacy and Compliance with Mandibular Advancement Splint Therapy for Obstructive Sleep Apnoea Jeremy Powers (United States) 3:30pm – 3:45pm System validation study for novel wearable sleep apnea screening device Niina Mäkinen (Finland) 3:45pm – 4:00pm Pulse wave amplitude drops (PWAD): a new biomarker of cardiovascular risk in patients with obstructive sleep apnea in HypnoLaus and ISAACC cohorts Geoffroy Solelhac (Switzerland) 4:00pm – 4:15pm Adjunct pharmacotherapy after upper airway surgery for obstructive sleep apnea: preliminary results of a parallelgroup, double-blind, randomized trial Eli van de Perck (Belgium)

O34: RLS AND SLEEP-RELATED MOVEMENT DISORDERS: PHYSIOPATHOLOGICAL CORRELATES 3:00pm – 4:30pm | Room 32 3:00pm – 3:15pm Association of BST1 polymorphism with idiopathic restless legs syndrome in Chinese population Yumeng Huang (China) 3:15pm – 3:30pm Structural Changes of the Subcortical Gray Structures in Restless Legs Syndrome Maria Paola Mogavero (Italy)

115 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

3:30pm – 3:45pm Noninvasive peroneal nerve stimulation reduces symptoms of Restless Legs Syndrome Bahman Adlou (United States) 3:45pm – 4:00pm Spectral electroencephalographic changes and heart rate variability accompanying leg movements during suggested immobilization test in patients with Restless Legs Syndrome Gulcin Benbir Senel (Turkey) 4:00pm – 4:15pm Clinical Impact and Polysomnographic Features of Sleep Disturbances in Multiple Sclerosis Davide Sparasci (Switzerland)

T05: UPDATE AND PERSPECTIVES IN SLEEP MEDICINE: THE EXPERIENCE OF SLEEP TECHNOLOGISTS PART 1 3:00pm – 4:30pm | Room 33 Chair: Paolo Matrigiani (Italy)

TUES

MARCH 15

WED

MARCH 16

S88: CHALLENGES AND THERAPEUTICAL PERSPECTIVES OF CENTRAL SLEEP APNEA 4:45pm – 6:15pm | Room 13 Chair: Winfried Randerath (Germany) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Phenotyping of central sleep apnea: Prognostic markers and basis of personalized treatment?

Winfried Randerath (Germany) 5:07pm – 5:27pm CSA – friend or foe: Pro/ Con debate Shahrokh Javaheri (United States); Michael Arzt (Germany) 5:27pm – 5:47pm Phrenic nerve stimulation, Buspirone and long-term oxygen therapy: are they therapeutical alternatives?

Shahrokh Javaheri (United States) 5:47pm – 6:07pm Opioid-induced CSA: Complex pathophysiology and therapeutical challenge Robert Thomas (United States)

3:00pm – 3:02pm Introduction Paolo Matrigiani (Italy) 3:02pm – 3:22pm REM sleep without atonia: Technical and methodological aspect of the visual quantification Francesco Famà (Italy) 3:22pm – 3:42pm Development, assessment and application of ambulatory PSG in sleep related motor behaviors Francesco Mignani (Italy) 3:42pm – 4:02pm Sleep Disordered Breathing: Different breathing patterns for different clinical condition Annalisa Rubino (Italy) 4:02pm – 4:22pm The role of the actigraphic monitoring in circadian rhythm and sleep-related disorders Matteo Spanetta (Italy) 4:22 – 4:30pm Question and answer

MON

MARCH 14

6:07pm – 6:15pm Question and answer

S89: SLEEP IN SAFETY-CRITICAL OCCUPATIONS WITH EXTENDED OPERATIONS OR MULTIPLE WORK PERIODS 4:45pm – 6:15pm | Room 14 Chair: Kati Karhula (Finland) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Military officers’ sleep and need for recovery Kati Karhula (Finland) 5:07pm – 5:27pm Sleep, health and workload in airline pilots: When can these factors put at risk aviation safety Cátia Reis (Portugal)

116 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

5:27pm – 5:47pm The importance of night-time sleep for shift-working nurses: Comparison of 12-hour and 16-hour shift schedules Tomohide Kubo (Japan)

S91: SLEEP, DREAMING AND THE ROAD TO SUICIDE RISK

5:47pm – 6:07pm Sleep and performance in on-call physicians: Can you trust them when waking them from sleep?

John Axelsson (Sweden)

4:45pm – 4:47pm Introduction

6:07pm – 6:15pm Question and answer

S90: NON-INVASIVE STIMULATION TECHNIQUES IN SLEEP DISORDERS: FROM NEUROPHYSIOLOGY TO NEUROMODULATION

4:47pm – 5:07pm The dreaming child: between nightmares and lucid dreams Carmen Schroder (France) 5:07pm – 5:27pm From dreams to nightmares: on the road to suicide Pierre Alexis Geoffroy (France) 5:27pm – 5:47pm Sleep and Dreaming in Posttraumatic Stress Disorder: Links with Suicide Risk Philip Gehrman (United States)

4:45pm – 6:15pm | Room 15 Chair: Giuseppe Lanza (Italy) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Technical-methodological background and clinical applications Francesco Fisicaro (Italy) 5:07pm – 5:27pm Non-invasive brain stimulation techniques in Restless Legs Syndrome (RLS) Yuping Wang (China) 5:27pm – 5:47pm Spinal excitability and neuromodulation treatment in Restless Legs Syndrome (RLS) Cornelius Bachmann (Germany) 5:47pm – 6:07pm Cortical-subcortical excitability in REM-sleep Behaviour Disorder (RBD) Michela Figorilli (Italy) 6:07pm – 6:15pm Question and answer

4:45pm – 6:15pm | Room 21 Chair: Célyne Bastien (Canada)

5:47pm – 6:07pm Insomnia and the road to suicide risk: what are the foundations?

Laura Palagini (Italy) 6:07pm – 6:15pm Question and answer

S92: EMERGING TREATMENT FOR PEDIATRIC OBSTRUCTIVE SLEEP APNEA 4:45pm – 6:15pm | Room 22 Chair: Indra Narang (Canada) 4:45pm – 4:47pm Introduction 4:47pm – 5:03pm Pressure vs. flow: Role of humidified high flow nasal cannula therapy in pediatric OSA Indra Narang (Canada) 5:03pm – 5:19pm Positional therapy in children with obstructive sleep apnea Lena Xiao (Canada)

117 | Scientific Program | WORLD SLEEP 2022

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

5:19pm – 5:35pm Drug induced sleep endoscopy in children with OSAS: Role in treatment selection and precision sleep surgery An Boudewyns (Belgium) 5:35pm – 5:51pm Growth modification therapy: Targeted orthodontic intervention in pediatric OSA Sujung Kim (Korea, Republic of) 5:51pm – 6:07pm Hypoglossal nerve stimulation therapy: Opportunities in pediatric OSA Umakanth Katwa (United States) 6:07pm – 6:15pm Question and answer

O35: NEW TECHNOLOGIES FOR SLEEP SCORING 4:45pm – 6:15pm | Room 23 4:45pm – 5:00pm Real-time implementation of sleep staging using interbeat intervals Gary Garcia-Molina (United States) 5:00pm – 5:15pm An automated heart rate-based algorithm for sleep stage classification: validation using conventional PSG and wearable ECG data Nicolò Pini (United States)

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

S93: PREDICTION OF CARDIOVASCULAR DISEASE IN OBSTRUCTIVE SLEEP APNEA: A STEP TOWARDS PRECISION CARE 4:45pm – 6:15pm | Room 24 Chair: Virend Somers (United States); Sanjay Patel (United States) 4:45pm – 4:47pm Introduction 4:47pm – 5:07pm Symptoms Clusters and Cardiovascular Disease Prediction Sanjay Patel (United States) 5:07pm – 5:27pm Doing More with Polysomnograms (PSG): Advanced PSG Metrics in Cardiovascular Prediction Ali Azarbarzin (United States) 5:27pm – 5:47pm Circulating Proteomics and Future Cardiovascular Risk in OSA Reena Mehra (United States) 5:47pm – 6:07pm Circulating RNA Biomarkers and Cardiovascular Risk Prediction in OSA Manuel Sánchez de la Torre (Spain) 6:07pm – 6:15pm Question and answer

5:15pm – 5:30pm Deep learning enables accurate automatic sleep staging based on ambulatory forehead EEG Akseli Leino (Finland)

O36: EXCESSIVE DAYTIME SLEEPINESS AND

5:30pm – 5:45pm Deep learning enables accurate automatic sleep staging based on ambulatory forehead EEG Matias Rusanen (Finland)

4:45pm – 5:00pm Sleep inertia measurement with the psychomotor vigilance task in idiopathic hypersomnia Elisa Evangelista (France)

HYPERSOMNIA 4:45pm – 6:15pm | Room 31

5:00pm – 5:15pm A global consensus regarding the evaluation and management of sleepiness in obstructive sleep apnoea: Results of a delphi process Atul Malhotra (United States)

118 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

FRI

MARCH 11

SAT

MARCH 12

SUN

MARCH 13

5:15pm – 5:30pm Prediction of risk factors of sleepiness at the wheel among patients with obstructive sleep apnea Abdel Kebir Sabil (France) 5:30pm – 5:45pm Discovery of a novel orally available selective orexin 2 receptor agonist, E2086, as a therapeutic drug for narcolepsy and other hypersomnia disorders Ken Hatanaka (Japan) 5:45pm – 6:00pm Autonomic Reflex Testing Confirms Autonomic Disturbances in a Cohort of Patients with Idiopathic Hypersomnia Jennifer Zitser Koren (United States)

O37: BEHAVIOR, COGNITION, MEMORY, AND DREAMING 4:45pm – 6:15pm | Room 32 4:45pm – 5:00pm Sleep Restriction impairs the ability to integrate multiple pieces of information into a decision Sean Drummond (Australia) 5:00pm – 5:15pm Obstructive Sleep Apnea severity, SIMOA assessed plasma Aβ42/Aβ40, and diagnosed CSF brain amyloidosis and tau pathology Omonigho Bubu (United States) 5:15pm – 5:30pm Sleeping while awake: sleep-like slow waves in wakefulness predict modulations of performance and subjective experience Thomas Andrillon (France)

MON

MARCH 14

TUES

MARCH 15

WED

MARCH 16

T06: UPDATE AND PERSPECTIVES IN SLEEP MEDICINE: THE EXPERIENCE OF SLEEP TECHNOLOGISTS PART 2 4:45pm – 6:15pm | Room 33 Chair: Paolo Matrigiani (Italy) 4:45pm – 4:47pm Introduction Paolo Matrigiani (Italy) 4:47pm – 5:07pm Telemedicine in the therapy of OSA Patients: CPAP titration, and follow-up for effective and long-lasting therapy Paolo Matrigiani (Italy) 5:07pm – 5:27pm In lab polysomnography vs. home polygraphy in children: Pros and cons Manuela Cecili (Italy) 5:27pm – 5:47pm Role of the Sleep Technician in the diagnosis and followup of narcolepsy Giulia Neccia (Italy) 5:47pm – 6:07pm A standardized test to document cataplexy Francesca Citeroni (Italy) 6:07pm – 6:15pm Question and answer

SOCIAL EVENT: CLOSING CEREMONY & RECEPTION 6:15pm – 8:00pm | Room 11

119 | Scientific Program | WORLD SLEEP 2022

120 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

MENTOR THE NEXT GENERATION OF LEADERS IN SLEEP SCIENCE & MEDICINE Organized by World Sleep Society, the International Sleep Research Training Program (ISRTP) prepares sleep science trainees around the world for future leadership in the sleep science field. The one-year comprehensive training program develops the mentee’s strengths in research design, communication and career development.

CURRENT MENTOR SITES: CHARITÉ UNIVERSITY HOSPITAL BERLIN

STANFORD UNIVERSITY

FLINDERS UNIVERSITY

UNIVERSITY MEDICAL CENTER FREIBURG

Sleep Medicine Center

Adelaide Institute for Sleep Health

HARVARD UNIVERSITY

Division of Sleep Medicine at Harvard Medical School

KING’S COLLEGE LONDON

Sleep Disorders Centre at Guy’s and St. Thomas’ NHS Foundation Trust

MEDICAL UNIVERSITY OF INNSBRUCK Department of Neurology & Neurosurgery

MONASH UNIVERSITY

Turner Institute for Brain and Mental Health

PEKING UNIVERSITY PEOPLE’S HOSPITAL

Division of Sleep Medicine

Albert-Ludwigs-Universität, Freiburg i. Brsg., Medical Centre, Department of Psychiatry and Psychotherapy, Centre for Sleep Research and Sleep Medicine

UNIVERSITY OF OXFORD

Sleep and Circadian Neuroscience Institute

UNIVERSITY OF PENNSYLVANIA Center for Sleep & Circadian Neurobiology

UNIVERSITY OF SYDNEY

Woolcock Institute of Medical Research

UNIVERSITY OF TSUKUBA

International Institute for Integrative Sleep Medicine

PKUPH Sleep Center

ST. JOHN’S MEDICAL COLLEGE HOSPITAL St. John’s Medical College Hospital, Department of Pulmonary, Critical Care and Sleep Medicine

JOIN ISRTP AND MENTOR THE NEXT GENERATION OF LEADERS IN SLEEP SCIENCE & MEDICINE. FOR MORE INFORMATION VISIT WORLDSLEEPSOCIETY.ORG/ISRTP

The education and experiences you provide to these mentees won’t be forgotten, and will build a lasting academic relationship and collaboration that will endure long after their year with you has concluded. Please join us...we look forward to working with you in further enhancing the academic environment for our program and mentees!

- Clete Kushida, MD, PhD (United | ISRTP Steering Committee 121 | Scientific Program | States) WORLD SLEEP 2022

Christian Guilleminault “CG” 1938 – 2019

THE CG FUND

In his memory, World Sleep Foundation, a nonprofit 501c(3) organization, has created an endowment in honor of Dr. Guilleminault, a sleep pioneer.

PURPOSE

To encourage young investigators in the field of sleep, especially in developing portions of the world, to advance Sleep Medicine & Research worldwide.

For more information visit worldsleep.info/yi

Dr. Christian Guilleminault, “CG” as he was known by colleagues, devoted his career to the development and advancement of sleep medicine & research.

Dr. Guilleminault is famous for his involvement in the first classification and identification of sleep disorders. His groundbreaking research in the areas of sleep apnea, pediatric sleep disorders and narcolepsy made him a leader in the field of sleep medicine and research. It was his life’s mission to develop and bring awareness of this new field—the creation of sleep medicine.

Dedicating his life to advancing the science and clinical practices of treating sleep apnea and sleep related conditions, Dr. Guilleminault touched the lives of patients and colleagues and remains a pioneer in the field of sleep medicine worldwide. Throughout his career, Dr. Guilleminault mentored hundreds of physicians and scientists.

ACCESSIBLE SLEEP TRAINING AROUND THE WORLD World Sleep Society is pleased to announce World Sleep Academy, a new online sleep medicine training program for healthcare professionals worldwide.

For more information and to apply visit worldsleepsociety.org/wsa

First course starts September 1, 2022

SPONSORS & EXHIBITORS

124 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

2022 SPONSORS

GOLD SPONSORS

SILVER SPONSORS

BRONZE SPONSORS

125 | Scientific Program | WORLD SLEEP 2022

INDUSTRY SYMPOSIUM & WORKSHOP SESSIONS

MON MARCH 14

Jazz Pharmaceuticals: Excessive Daytime Sleepiness (EDS) in OSA – A Complex and Challenging Reality 12:30pm – 2:00pm | Room 11 Chair: Luigi Ferini-Strambi (Italy)

ProSomnus Sleep Technologies: Personalized Care and Precision Medicine in Sleep Apnea: Emerging Technologies and Latest trends in Treating Sleep Apnea with Non-CPAP Therapies 12:30pm – 2:00pm | Room 21 Chair: Edward Sall (United States)

Sleep Number: Can the sleeping environment be optimized to improve sleep quality?

12:30pm – 2:00pm | Room 13 Chair: Eve Van Cauter (United States)

Neurim Pharmaceuticals: Advances in insomnia in ASD – from research to clinical practice 12:30pm – 2:00pm | Room 22 Chair: Oliviero Bruni (Italy)

Philips: Management of sleep patients with cardiovascular disease 12:30pm – 2:00pm | Room 14 Chair: Winfried Randerath (Germany)

ResMed: A new way to run clinical research in sleep medicine: Why does it matter?

Takeda Pharmaceuticals: Navigating Narcolepsy: The Science of Orexin and Diagnostic Challenges

12:30pm – 2:00pm | Room 23 Chairs: Christoph Schöbel (Germany); Kimberly Sterling (United States)

12:30pm – 2:00pm | Room 15 Chair: Giuseppe Plazzi (Italy)

126 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

TUES

MARCH 15

Idorsia: Insomnia – a wake-up call 12:30pm – 2:00pm | Room 11 Chair: Charles Morin (Canada)

ResMed: How to improve sleep apnoea management using Patient-Reported Outcome Measurements 12:30pm – 2:00pm | Room 23 Chairs: Kimberly Sterling (United States); Anita Simonds (United Kingdom)

Avadel Pharmaceuticals: Addressing patient needs in the advancement of narcolepsy treatment 12:30pm – 2:00pm | Room 13 Chairs: Yves Dauvilliers (France); Michael Thorpy (United States)

Activinsights: Beyond actigraphy: accelerometry and sleep biomarkers from wearables 1:00pm - 1:45pm | Room 32 Chair: Joss Langford (United Kingdom)

Bioprojet: EDS management in OSA, the new approaches 12:30pm – 2:00pm | Room 15 Chair: Maria Rosaria Bonsignore (Italy)

WED

MARCH 16

Nox Medical: Beyond the AHI

NLS Pharmaceutics: Quilience (Mazindol ER) a new

12:30pm – 2:00pm | Room 22 Chair: Carolina Lombardi (Italy)

approach for Type I & Type II narcolepsy: POLARIS clinical development program 12:30pm – 2:00pm | Room 22 Chair: Michael Thorpy (United States) 127 | Scientific Program | WORLD SLEEP 2022

EXHIBIT HALL FLOOR PLAN FOOD SERVICE AREA

780

50mq

FOOD

EXHIBITION AREA 173 271

571 573

771 773

562 564

762 764

360

162

50mq

450

50mq

560

752 753

554 655 340

150 mq

440

50mq

135 231 233

546 647

746 751

544 645

744

540

742

743

235

126 222 224 226 228

410

100 mq

115 211 213 215 217

710

100 mq

EXHIBIT HALL ENTRANCE

128 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

Rev 2/4/2021

2022 EXHIBITORS EXHIBITOR NAME..................... BOOTH# ACTIVINSIGHTS ........................................... 762

NARCOLEPSY NETWORK .............................. 224

ADVANCED BRAIN MONITORING .................. 546

NLS PHARMACEUTICS .................................. 780

AMCAD BIOMED CORPORATION .................. 573

NOX MEDICAL ............................................. 235

AMLIFE ....................................................... 773

NUKUTE ...................................................... 647

AVADEL PHARMACEUTICALS .........................710

ORTHOAPNEA ............................................. 554

BIOPROJET PHARMA .................................... 450

PANTHERA DENTAL ....................................... 115

BITTIUM....................................................... 746

PROSOMNUS SLEEP TECHNOLOGIES ............ 562

THE BOARD OF REGISTERED POLYSOMNOGRAPHIC TECHNOLOGISTS .......213

RESMED ...................................................... 540

CEREBRA .................................................... 560 DATWYLER .................................................. 744 DIAMETOS GMBH .........................................271 DORMIFLEX ................................................. 743 EUROPEAN SLEEP RESEARCH SOCIETY ...........215 FIDIA FARMACEUTICI S.P.A. ...........................771 FISHER & PAYKEL HEALTHCARE SAS ............... 564 HAPPIEST BABY ........................................... 655 HEROIC FAITH...............................................751 HYPERSOMNIA FOUNDATION ...................... 222 IDORSIA .......................................................217 JAZZ PHARMACEUTICALS ............................. 340 LÖWENSTEIN MEDICAL TECHNOLOGY ...........571 MOONA ..................................................... 544 MYAIRGO.....................................................231

SLEEP INSTITUTE........................................... 226 SLEEP NUMBER ............................................ 440 SLEEPIZ ....................................................... 742 SOMNOMED ................................................410 SOMNOMEDICS GMBH ................................ 645 TAKEDA ...................................................... 228 TUFTS UNIVERSITY SCHOOL OF DENTAL MEDICINE, OFFICE OF CONTINUING EDUCATION ................................................. 211 VIVISOL SRL ................................................. 360 VIVOS THERAPEUTICS....................................173 ZOLL ITAMAR ............................................... 233

EXHIBIT HALL HOURS Monday: 9:30am–4:00pm Tuesday: 9:30am–4:00pm Wednesday: 9:30am–2:00pm Exhibition will be closed and monitored by security before 8:30am and after 5:00pm.

129 | Scientific Program | WORLD SLEEP 2022

WORLD SLEEP 2022 FLOOR PLAN

ROMA CONVENTION CENTER | LEVEL 1 | WORLD SLEEP FOOD SERVICE AREA

COAT CHECK

780

50mq

FOOD

EXHIBITION AREA 173 271

REGISTRATION AREA

MAIN ENTRANCE

INTERNET CAFE

771 773

562 564

762 764

360

162

A06

571 573

50mq

(+19,30)

450

A07

560

50mq

752 753

_ ELEVATORI

554 655 340

150 mq

546 647

746 751

544 645

744

540

742

440

50mq

NETWORK BOOTH LOUNGE

743

235

135 231 233

126 222 224 226 228

710

410

100 mq

100 mq

115 211 213 215 217 *

* *

* **

41

**

A15 *

45

* *

42

* *

* *

*

EXHIBIT HALL ENTRANCE

A16

*

**

**

*

*

*

43

* *

A17

*

A36

MASPERO ELEVATORI

A14

*

*

TO LEVEL 2

POSTER AREA *

45

*

*

*

* *

*45 *

*

*

*

*

*

*

* *

*

A24

*

45

*

THE YELLOW LOUNGE

A21

* *

45

*

* *

*

*

* * 45 * 45

* *

*

* *

* *

* *

* *

* *

130 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

* *

**

45 45

* *

* *

* *

* *

** **

LEVEL 1 ROMA CONVENTION CENTER LA NUVOLA

A4-50 A4-49

A2-50

A4-48

A2-49

A4-47

A2-48

A4-46

A2-47

A4-45

A2-46

A4-44

A2-45

A4-43

A2-44

A4-42

A2-43

SCREEN

14

SCREEN

13

SCREEN

VENUE & LOCATION

SCREEN

Roma Convention Center La Nuvola Viale Asia, 40, 00144 Roma RM, Italy romaconventiongroup.it

A4-33

A2-34

A4-34

A2-35

A4-35

A2-36

A4-36

A2-37

A4-37

A2-38

A4-38

A2-39

A4-39

A2-40

A4-40

A2-41

A4-41

A2-42

15

A4-32

SCREEN C2-06

C2-07

A4-31

A2-32

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24 B2-01

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WORLD SLEEP 2022 FLOOR PLAN

ROMA CONVENTION CENTER | 2ND LEVEL/MEZZANINE | WORLD

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133 | Scientific Program | WORLD SLEEP 2022

SPONSORS & EXHIBITORS

Booth Number: 762 activinsights.com Activinsights is a digital health company that specialises in the objective measurement of physical behaviours and lifestyle.

Our technologies are used worldwide within the clinical trials, health management and research markets to provide accurate and continuous monitoring of lifestyle outside of the clinic environment. We develop novel health measures from data collected by our own professional wearables and other connected devices, within a scalable global and secure infrastructure.

Booth Number: 546 advancedbrainmonitoring.com Advanced Brain Monitoring specializes in the acquisition and analysis of physiological signal obtained during wake and sleep, and in the treatment of sleep-disordered breathing.

Sleep Profiler monitors sleep quality in the home or ICU, provides unattended PSG, and/or delivers prodromal biomarkers for neurodegenerative disease. Night Shift provides electronic positional therapy from the neck or chest.

Apnea Guard® is a trial oral appliance that provides equivalent efficacy as a custom appliance.

Booth Number: 573 amcadbiomed.com/product/uo AmCad BioMed Corporation (AmCad) is a pioneering ultrasound AI software company, creates a world’s first ultrasound based obstructive sleep apnea (OSA) detection in 10 minutes for awake patients, AmCAD®-UO. With laserguided positioning and automated ultrasound scanning device, AmCAD®-UO can precisely scan upper airway and analyze the gap between normal breathing and Müller Maneuver. AmCAD®-UO system standardizes ultrasound transducer scanning to make the assessment more consistent and avoid high operator dependent variations.

Booth Number: 773 amlife.com AmLife commenced its sleep healthcare business in 2014. The company has pioneered the combination of a bedding equipment with Japan’s technology to expand the unlimited potential of the sleep healthcare market by providing a health solution for the daily use of a modern-day community. AmLife committed in promoting sleep health activities in the past few years, and AmLife holds a major World Sleep Day event each year.

apnimed.com

Apnimed is a clinical-stage pharmaceutical company working to transform the treatment of sleep apnea based on a simple idea – patients with obstructive sleep apnea could benefit from treatment with a safe and effective oral medication dosed once-daily at bedtime. Apnimed’s lead development program targets the neurologic control of upper airway muscles to maintain an open airway during sleep. The company is developing a portfolio of novel pharmacologic therapies for sleep apnea and related disorders.

GOLD SPONSOR Booth Number: 710 avadel.com Avadel is transforming medicines to transform lives by applying innovative solutions to the development of medications that address the challenges patients face with current treatment options. Avadel’s current lead drug candidate, FT218, is an investigational formulation of sodium oxybate leveraging its proprietary drug delivery technology and designed to be taken once at bedtime for the treatment of excessive daytime sleepiness or cataplexy in adults with narcolepsy.

134 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

SPONSORS & EXHIBITORS

SILVER SPONSOR

Booth Number: 560 cerebra.health

Booth Number: 450 bioprojet.com/en/homepage The Bioprojet company was founded in 1982 under the impetus of Jeanne-Marie Lecomte and Jean-Charles Schwartz, doctors of pharmacy and sciences. From very different backgrounds, Jeanne-Marie Lecomte made her career in the pharmaceutical industry, whereas Jean-Charles Schwartz continued down the university pathway. They decided to bring together academic research and industrial pharmaceutical development, an uncommon practice at that time. With Bioprojet, they are following an objective based on novel fundamental research work in order to design and develop drugs destined to be forerunners in new therapeutic groups.

Cerebra is putting the “sleep back into sleep medicine”, transforming the future of sleep diagnosis and therapy through self-applied in-home polysomnography and our patented Odds Ratio Product (ORP). ORP moves beyond conventional scoring by micro analyzing the EEG signal to dig deeper into brain activity during sleep. This provides new insights in mental, physical, and emotional health. Cited in peer reviewed sleep research, ORP is the most accurate measure of sleep depth.

Booth Number: 744 compumedics.com Booth Number: 746 bittium.com/medical Bittium offers medical technology for monitoring biosignals in the areas of cardiology, neurophysiology, rehabilitation, and occupational health. Bittium develops cutting-edge technology for monitoring ECG and EEG. Bittium’s cardiac monitoring devices and applications include Holtering, cardiac telemetry, and cardiac rehabilitation. Bittium has EEG solutions for first aid and intensive care, TMS-EEG, and fMRI-EEG.

Datwyler is focusing on high-quality, system-critical elastomer components and has leading positions in attractive global markets such as healthcare, mobility, food & beverage and general industry. With its recognized core competencies, the company delivers added value to customers in the markets served. With more than 20 operating companies, sales in over 100 countries and some 7’000 employees Datwyler, headquartered in Switzerland, generates annual sales of more than CHF 1’000 million.

Booth Number: 213 brpt.org The mission of The Board of Registered Polysomnographic Technologists (BRPT) is to build upon its history as the global leader in sleep technologist credentialing and certification; to provide high quality sleep technology products and services that inspire professional excellence, recognition, and lifelong learning; and to create long-term value for credential and certificate holders.

135 | Scientific Program | WORLD SLEEP 2022

SPONSORS & EXHIBITORS

Booth Number: 271 diametos.com Diametos’ product Somnofox is the world’s first and only medical device for the analysis of the anatomical causes of snoring. Using artificial intelligence, the acoustic subtleties of the snoring sounds are analyzed, and the sleep specialist receives a detailed report. In addition, Diametos’ medical App Snorefox offers patients an easy way to assess the risk of Sleep Apnea at home. – Diametos makes snoring diagnostics as easy as snoring itself.

elsevier.com Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, and deliver better care.

Booth Number: 215 esrs.eu Booth Number: 743 dormiflex.it Dormiflex is a Venetian company specialised in the production of bed systems for the residential medical/health sector. The products are entirely made in Italy using only high-quality materials and the first company for Medical Devices. Dormiflex was established in 1964. Dormiflex is even capable of guaranteeing dreams, through technology, tradition and the continuous innovation of its patents with relentless research and development of the best sleeping solutions.

The ESRS is an international scientific non-profit organization that aims to: promote all aspects of sleep research and sleep medicine, improve the care for patients with sleep disorders and facilitate the dissemination of information regarding sleep research and sleep medicine. To do this, we publish the Journal of Sleep Research and Sleep Medicine Textbook, organize scientific events, including our biennial Sleep Europe Congress and offer several fellowships, grants and awards.

Booth Number: 771 fidiapharma.com

GOLD SPONSOR eisai.com Eisai Co., Ltd. is a leading global research and developmentbased pharmaceutical company headquartered in Japan. We define our corporate mission as “giving first thought to patients and their families and to increasing the benefits health care provides,” which we call our human health care (hhc) philosophy.

Italian developer and leading manufacturer of innovative products mainly based on hyaluronic acid (+1,100 patents), in joint care, wound care, ophthalmology, uro-gynecology, aesthetic and regenerative medicine. Products are available in +100 countries, through wholly owned subsidiaries and partners. Fidia’s commitment is also dedicated to pathologies such as sleep disorders, mood regulation and peripheral neuropathies, realized through a valid offer of therapeutic options which are confirmed by a consolidated use over the years and by innovative proposals.

136 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

SPONSORS & EXHIBITORS

Booth Number: 564 fphcare.com/nz

GOLD SPONSOR

Fisher & Paykel Healthcare. We are a leading designer, manufacturer and marketer of products and systems for use in acute and chronic respiratory care, surgery and the treatment of obstructive sleep apnea. Driven by a strong sense of purpose, we are working to improve patient care and outcomes through inspired and world leading healthcare solutions. The needs of our customers and their patients drive everything we do. We call this commitment Care by Design.

Booth Number: 217 idorsia.com Headquartered in Switzerland – a biotech-hub of Europe – Idorsia is a high-potential biopharmaceutical company, specialized in the discovery, development and commercialization of innovative small molecules, with the aim of transforming the horizon of therapeutic options.

GOLD SPONSOR

Booth Number: 655 happiestbaby.com

Booth Number: 340

Happiest Baby is a mission-driven company dedicated to helping parents succeed at their most important job – raising healthy, happy children. We solve parenting challenges with smart, science-based solutions. SNOO Smart Sleeper-the safest baby bed ever made-is a responsive bassinet that boosts a baby’s sleep by combining gentle rocking with soothing white noise and safe swaddling. Created by Dr. Harvey Karp, SNOO helps babies by imitating the calming sensations of the womb.

Jazz Pharmaceuticals is a global biopharmaceutical company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases – often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines and novel product candidates, from early- to late-stage development, in neuroscience and oncology. INT-JPC-2100037 | October 2021

Booth Number: 571 hul.de

Booth Number: 222 hypersomniafoundation.org The Hypersomnia Foundation engages, informs and champions our global community to improve the lives of people with idiopathic hypersomnia and related sleep disorders.

Löwenstein Medical is dedicated to the development, production, sales and marketing of medical devices in three main business divisions – hospital, homecare and diagnostics.

Workstations for anesthesia, neonatology, pediatrics and intensive care ventilation describe the focus areas in the hospital segment. Moreover are diagnostic and therapeutic solutions for sleep medicine and homecare ventilation among the core competencies of the firm.

137 | Scientific Program | WORLD SLEEP 2022

SPONSORS & EXHIBITORS

SILVER SPONSOR

Booth Number: 544 getmoona.com Moona’s mission is to improve sleep for millions using breakthrough technology and AI. Medical research shows that temperature is a key factor in sleep quality. Fluctuations in body temperature regulate the body’s circadian rhythm, and our sleep. Using this link between body temperature and sleep, Moona’s first product tracks and understands sleep then regulates the head and neck temperature through a thermoregulated pillow pad, a pod, and a companion app.

Booth Number: 224 narcolepsynetwork.org Founded in 1986, Narcolepsy Network is the national U.S. membership-governed organization dedicated to improving the lives of people with narcolepsy. Our goals include increasing public awareness, advocating for all people with narcolepsy, educating people with narcolepsy and the public at large and supporting research.

Booth Number: 780 nlspharma.com NLS Pharmaceutics is a Swiss clinical-stage biopharmaceutical company led by an experienced management team with a track record of developing and repurposing product candidates to treat rare and complex CNS disorders. The Company’s lead product candidate, a proprietary extendedrelease formulation of mazindol (mazindol ER), is being evaluated in a phase 2 study in the US in adult subjects with narcolepsy. Mazindol is a triple monoamine reuptake inhibitor and partial orexin-2 receptor agonist.

BRONZE SPONSOR Booth Number: 235 noxmedical.com Nox Medical provides sleep specialists with patient-friendly sleep diagnostic devices and robust, reliable data collection.

With easy-to-use medical device technology, Nox Medical eliminates common diagnostic pain points by prioritizing patient comfort and reliability of results, allowing providers to better assess, diagnose and treat the entire range of sleep health issues.

BRONZE SPONSOR neurim.com Neurim Pharmaceuticals Ltd. (www.neurim.com) is a pharma company focusing on discovering and developing innovative drugs for CNS diseases. In response to the unmet medical need of children with ASD suffering from insomnia, Neurim developed Slenyto® – the first and only age-appropriate formulation, indicated for the treatment of insomnia in children and adolescents aged 2-18 with ASD or Smith-Magenis syndrome (SMS).

Booth Number: 647 nukute.com Nukute introduces a novel method for home sleep apnea testing and the remote diagnosing of sleep apnea. Careful thought has been put into the usability of the system and patient comfort during sleep. Please find out more from the poster “Novel wearable technology to screen for sleep apnea”, accompanied by its oral presentation at World Sleep 2022 and visit our booth 647 at the Exhibit Hall.

138 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

SPONSORS & EXHIBITORS

Booth Number: 554 orthoapnea.com

BRONZE SPONSOR

OrthoApnea is a Spanish company that designs, manufactures and supplies since 1992 Mandibular Advancement Devices (MADs) for treating Obstructive Sleep Apnea Syndrome.

OrthoApnea has launched NOA, the first MAD designed based on the anatomy of the patient considering their arthrokinematic parameters. NOA is a 100% unique device for each patient and therefore the most effective, most comfortable and safest device. Our core values are innovation, quality, efficiency and customer service.

Booth Number: 562 prosomnus.com ProSomnus is the leader in precision, patient preferred oral appliance devices for OSA. 96% of patients prefer ProSomnus devices, citing comfort and resolution of complaints (IRB, 2021). Biomechanically engineered, studies associate ProSomnus devices with excellent efficacy, adherence, and mitigation of side effects.

BRONZE SPONSOR

Booth Number: 115 pantheradental.com Panthera Dental is committed to design and manufacture state-of-the-art products using proprietary CAD/CAM processes, smart manufacturing and superior quality materials, to provide the highest quality outcomes through their highly skilled and dedicated employees, to deliver peerless solutions to dental, medical and sleep professionals who strive to improve patients’ quality of life worldwide.

BRONZE SPONSOR

Booth Number: 540 resmed.com/en-us At ResMed we pioneer innovative solutions that treat and keep people out of the hospital, empowering them to live healthier, higher-quality lives. Our digital health technologies and cloudconnected medical devices transform care for people with sleep apnea, COPD, and other chronic diseases. More info on Resmed.com.

SILVER SPONSOR

usa.philips.com Philips is a leading health technology company focused on improving people’s lives across the health continuum – from healthy living and prevention, to diagnosis, treatment and home care. Applying advanced technologies and insights, Philips addresses the Quadruple Aim: improved patient experience, better health outcomes, improved staff experience, and lower cost of care. Philips is a leader in diagnostic imaging, image-guided therapy, patient monitoring and health informatics, as well as in consumer health and home care.

Booth Number: 440 sleepnumber.com/science Sleep Number delivers life-changing innovations informed by science. Aligned with our purpose of improving the health and wellbeing of society, we’re committed to advancing sleep health, linking smart sleep to individualized wellness via innovations informed by data and scientific expertise. Our proprietary sleep ecosystem and real-world sleepers generate billions of accurate, longitudinal data points every night, conducting one of the largest real-world sleep studies each night.

139 | Scientific Program | WORLD SLEEP 2022

SPONSORS & EXHIBITORS

Booth Number: 742 sleepiz.com

BRONZE SPONSOR

Sleepiz AG (Ltd.) is a Zürich based startup with a mission to provide patient-centric disease management through seamless integration of contactless monitoring into people’s homes. Sleepiz leverages the power of sleep insights with a non-contact device that is simply placed next to the bed. The Sleepiz One Connect measures breathing rate and patterns, pulse and SpO2 with medical grade accuracy. Sleepiz is touching lives without touching.

Booth Number: 228 takeda.com Takeda Neuroscience is driven by the unmet needs of patients with rare neurological diseases. Our mission is to bring innovative and potentially disease-modifying medicines to these patients. To deliver on this mission, our approach leverages advances in molecularly and genetically defined targets, biomarkers, and targeted modalities.

VV-MEDMAT-51200. 09/2021.

GOLD SPONSOR Booth Number: 410 SomnoMed.com SomnoMed® is an Australian Stock Exchange listed medical device company operating in 28 countries, with headquarets in Sydney, Australia and offices in Europe and the United States. SomnoMed® focuses on developing and manufacturing clinically proven medical devices for the treatment of Obstructive Sleep Apnea (OSA) and more than 625,000 patients around the world have been successfully treated with our oral appliances.

Booth Number: 211 dental.tufts.edu/continuing-education Tufts University School of Dental Medicine, Division of Continuing Education is dedicated to providing patientcentered and clinical-based education for the lifelong learning needs of dental professionals. We strive to develop educational programs that address different patient populations, dental specialties, advancing technologies, and varied practice settings. We create and coordinate programs that incorporate all type of educational methodologies, quality training, and the highest standards of oral health care by utilizing a comprehensive and multidisciplinary approach.

Booth Number: 645 somnomedics.eu SOMNOmedics designs, manufactures, markets, distributes and services products dedicated to sleep diagnostics. Our products are utilized for a variety of sleep related tests and comply with the AASM standards. SOMNOmedics devices are small, lightweight and worn by the patient. We are compatible with in lab diagnostics as well as home sleep testing.

SOMNOmedics wireless solution allows patients video, audio and data to be observed from any environment.

140 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

SPONSORS & EXHIBITORS

Booth Number: 360 vivisol.com Vivisol is one of the leading Home Care Service Providers in Europe. Our patient management model includes all components of care: healthcare services, highly complex technological therapies and digital tools that allow to make the home environment proper to give continuity to the care path. Managing thousands of patients suffering from Sleep disorders, we are committed to offer innovative services by investing in diagnostic, therapeutic and follow-up personalized solutions.

AD INDEX AmLife.................................................. 120 Apnimed.............................................. 123 Avadel Pharmaceuticals ......... 28, Back Cover Bioprojet Pharma..................................... 29

Booth Number: 173 vivos.com Vivos Therapeutics Inc. (NASDAQ: VVOS) is a medical technology company focused on developing and commercializing innovative treatments for patients suffering from sleep disordered breathing, including obstructive sleep apnea (OSA). Vivos believes that its Vivos System technology represents the first clinically effective non-surgical, noninvasive, non-pharmaceutical and cost-effective solution for people with mild-to-moderate OSA.

Idorsia.................................................... 19 ISSTA.................................................... 142 Jazz Pharmaceuticals..................................7 Neurim Pharmaceuticals........................... 37 NLS Pharmaceutics................................... 37 Nox Medical....................................... 4, 39 Nukute................................................... 35 ProSomnus Sleep Technologies................. 34 ResMed.................................................. 18

Booth Number: 233 itamar-medical.com

Sleep Number......................................... 39

Our prescription WatchPAT® family of products, which utilize the PAT® signal, is designed to enable patients suspected to have sleep-related breathing disorders to easily conduct sleep apnea test in the comfort of their homes in accordance with physicians instructions, as authorized by qualified medical personnel while delivering the treating physician with comprehensive, accurate and reliable results to aid in diagnosis of sleep apnea.

SomnoMed Ltd.............Inside Front Cover, 38 Takeda................................................... 15 Tufts University School of Dental Medicine, Office of Continuing Education............................................. 142

141 | Scientific Program | WORLD SLEEP 2022

Boston, Massachusetts USA

Tufts University School of Dental Medicine is proud to provide high quality Dental Sleep Medicine programs that reflect the most up-to-date and revolutionary information on the subject and interactive workshops.

REGISTRATION OPEN, SEATS ARE LIMITED

Dental Sleep Medicine Mini-Residency 2022-2023

6-month program with one 3-day and two half-day live-streamed online modules and two 3-day on campus modules October 2022 - April 2023

Pediatric Dental Sleep Medicine Mini-Residency 2022-2023 6-month program with three live-streamed lecture days and one 3-day workshop module December 2022 - June 2023

For course dates and details visit us at dental.tufts.edu/CE 142 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

ADVANCING SLEEP HEALTH WORLDWIDE MISSION

The mission of World Sleep Society is to advance sleep health worldwide. World Sleep Society will fulfill this mission by promoting and encouraging education, research and patient care throughout the World, particularly in those parts of the world where the practice of sleep medicine is less developed.

OPERATING PROGRAMS

World Sleep Society developed the following programs that consist of promoting sleep education, awareness, and member services.

BEST OF SLEEP MEDICINE & RESEARCH BIENNIAL MEETING

In an effort to increase global awareness of sleep issues, World Sleep Society has formed relationships with the following sleep societies or regional federations.

• American Academy of Sleep Medicine (AASM)

• Hong Kong Society of Sleep Medicine

• ASEAN Sleep Federation

• Indian Association of Surgeons for Sleep Apnoea

• Asian Sleep Research Society • Asian Society of Slee Medicine • Australasian Sleep Association • Australasian Sleep Technologist Association

WSS

CONGRESS

ASSOCIATE SOCIETY MEMBERS

rld Sleep Day

International Sleep Disorder Specialist

Hosted by World Sleep Society

EXAM PROVIDING SLEEP MEDICINE COMPETENCE

ANNUAL AWARENESS EVENT WITH CALL TO ACTION

• Austrian Sleep Research Association (ASRA) • Brazilian Sleep Society • British Sleep Society • Bulgarian Association of Obstructive Sleep Apnea & Snoring • Canadian Sleep Society

OFFICIAL JOURNAL OF WORLD SLEEP SOCIETY Official journal of World Sleep Society & International Pediatric Sleep Association

PATIENT BASED HEALTHIER SLEEP MAGAZINE

ENDOWMENT IN HONOR OF SLEEP PIONEER

MENTORING & TRAINING SLEEP RESEARCH LEADERS

RECOMMENDATIONS FOR DIAGNOSIS & TREATMENT

• International RLS Study Group • Israel Sleep Research Society • Italian Association of Sleep Medicine • Japanese Society of Sleep Research • Minnesota Sleep Society • Peruvian Association of Sleep Medicine (APEMES) • Portuguese Sleep Association

• Czech Sleep Research and Sleep Medicine Society

• Romanian Association for Pediatric Sleep Disorders

• EURLSSG

• Russian Society of Somnologists

• European Academy of Dental Sleep Medicine (EADSM)

• Serbian Sleep Society

• Finnish Sleep Research Society

ACCESSIBLE SLEEP TRAINING AROUND THE WORLD

• International Pediatric Sleep Association (IPSA)

• CMDASM -Chinese Medical Doctor Association Sleep Medicine Specialized Committee

• Federation of Latin American Sleep Societies

GUIDELINES

• Integrated Sleep Medicine Society Japan (ISMSJ)

• Chinese Sleep Research Society

• European Sleep Research Society

INTERNATIONAL SLEEP

• Indian Sleep Disorders Association • Indian Society for Sleep Research

• Sleep and Wakefulness Medicine Moroccan Federation • Sleep Research Society • South East Asian Academy of Sleep Medicine

• French Society for Sleep Research and Sleep Medicine

• Taiwan Society of Sleep Medicine

• Georgian Sleep Research and Sleep Medicine Society

• Vietnam Society of Sleep Medicine

• German Sleep Society

• Turkish Sleep Medicine Society

UPCOMING WORLD SLEEP MEETINGS For information visit WORLDSLEEPCONGRESS.COM

CONNECT WITH US

3270 19th Street NW, Suite 109 Rochester, MN 55901 USA

info@worldsleepsociety.org

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NOTES

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145 | Scientific Program | WORLD SLEEP 2022

BECOME A MEMBER

Join our distinguished membership community of physicians, researchers and sleep professionals.

All individual memberships include the following benefits: • Access to international standards, best practices and current research in the field of sleep medicine • Access to Sleep Medicine journal (all memberships receive online and app access; full membership also includes printed journal) • Discounted pricing for the biennial World Sleep Congress

Nonmember Registration .............. $500 Full-day Course ............................... $165 CME credits ..................................... $25 TOTAL ............................................... $690

MEMBER REGISTRATION WORLD SLEEP 2022

• Eligibility to serve on a World Sleep committee • Eligibility to participate and vote in general assembly meetings

Official journal

Official

journal

of World

n Sleep Associatio al Pediatric Official journal of&World Sleep Society & International Pediatric Sleep Association Internation Society of World Sleep

Sleep Society

ic Sleep

tional Pediatr

& Interna

tion

Associa

• Use the “International Sleep Specialist” designee after successfully passing the Sleep Medicine Examination For more information visit, worldsleepsociety.org/membership

+1-507-316-0084

NONMEMBER REGISTRATION WORLD SLEEP 2022

Regular Annual Membership ........ $55 Member Registration...................... $375 Full-day Course ............................... $165 CME credits ..................................... $25 TOTAL ............................................... $620

TOTAL SAVINGS $70!

worldsleepsociety.org

info@worldsleepsociety.org

3270 19th Street NW, Suite 109 Rochester, MN 55901 USA 146 | For the latest updates, visit WORLDSLEEPCONGRESS.COM

twitter.com/_WorldSleep facebook.com/wasmf

World Sleep Society & the Brazilian Sleep Society Present the Best of Sleep Medicine & Research

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