Issuu

If you’re living with HIV, you may face another clinical challenge to healthy aging

Egrifta Color Ad Help Curb Excess Abdominal VAT Visceral adipose tissue (VAT) isn’t regular fat. VAT is a hard fat that surrounds organs, may be associated with serious health issues, and can be difficult to control with diet and exercise alone.

EGRIFTA ® (tesamorelin for injection) is the only FDA-approved treatment for excess HIV-related abdominal VAT EGRIFTA ® was shown to reduce VAT in 2 clinical trials of 816 total adult patients who received 2 mg of EGRIFTA ® or placebo (26-week Main Phase and 26-week Extension Phase).a Trial 1: 18% average reduction. Trial 2: 14% average reduction. For additional trial details, see the full Prescribing Information at EGRIFTA.com.

EGRIFTA® is not indicated to treat health issues beyond the reduction of excess abdominal VAT.

SELECTED RISK INFORMATION What is EGRIFTA ®? • EGRIFTA ® is an injectable prescription medicine to reduce the excess in abdominal fat in HIV-infected patients with lipodystrophy. The impact and safety of EGRIFTA ® on cardiovascular health has not been studied. • EGRIFTA ® is not indicated for weight loss management. • It is not known whether taking EGRIFTA ® helps improve compliance with anti-retroviral medications. EGRIFTA ® may cause serious side effects including: • Serious allergic reaction. Stop using EGRIFTA ® and get emergency help right away if you have symptoms such as a rash over your body, hives, shortness of breath or trouble breathing, swelling of your face or throat, fast heartbeat, and feeling of faintness or fainting.

• Swelling (fluid retention). EGRIFTA ® can cause swelling in some parts of your body. • Increase in glucose (blood sugar) intolerance and diabetes. • Injection site reactions. Change (rotate) your injection site to help lower your risk for injection site reactions. The following symptoms around the area of the injection site can occur: redness, itching, pain, irritation, bleeding, rash, and swelling. The most common side effects of EGRIFTA ® include: joint pain, pain in legs and arms, swelling in your legs, muscle soreness, tingling, numbness and pricking, nausea, vomiting, rash, and itching. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Please see brief summary of full Important Patient Information on next page.

Learn more at EGRIFTA.com

A Transformation From Within

IMPORTANT PATIENT INFORMATION The following is a brief summary only. See complete Prescribing Information at EGRIFTA.com or request complete Prescribing Information by calling 1-844-347-4382. This information does not take the place of talking to your doctor about your medical condition or your treatment. What is EGRIFTA ® (tesamorelin for injection)? • EGRIFTA ® is an injectable prescription medicine to reduce the excess in abdominal fat in HIV-infected patients with lipodystrophy. The impact and safety of EGRIFTA ® on cardiovascular health has not been studied. • EGRIFTA ® is not indicated for weight loss management. • It is not known whether taking EGRIFTA ® helps improve compliance with anti-retroviral medications. Do not use EGRIFTA ® if you: • have pituitary gland tumor, pituitary gland surgery or other problems related to your pituitary gland. • have active cancer or are receiving treatment for cancer • are allergic to tesamorelin or mannitol. • are pregnant or become pregnant. If you become pregnant, stop using EGRIFTA ® and talk with your healthcare provider. Talk to your doctor to find out if EGRIFTA ® is right for you. How should I use EGRIFTA ®?

• Swelling (fluid retention). EGRIFTA ® can cause swelling in some parts of your body. Call your healthcare provider if you have an increase in joint pain, or pain or numbness in your hands or wrist (carpal tunnel syndrome). • Increase in glucose (blood sugar) intolerance and diabetes. Your healthcare provider will measure your blood sugar periodically. • Injection-site reactions. Change (rotate) your injection site to help lower your risk for injection-site reactions. Call your healthcare provider for medical advice if you have the following symptoms around the area of the injection site: • redness • bleeding • itching • rash • pain • swelling • irritation The most common side effects of EGRIFTA ® include: • joint pain • nausea • pain in legs and arms • vomiting • swelling in your legs • rash • muscle soreness • itching • tingling, numbness and pricking

• Read the detailed “Instructions for Use” that comes with EGRIFTA ® before you start using EGRIFTA ®. Your healthcare provider will show you how to inject EGRIFTA ®. • Use EGRIFTA ® exactly as prescribed by your healthcare provider. • Inject EGRIFTA ® under the skin (subcutaneously) of your stomach area (abdomen). • Change (rotate) the injection site on your stomach area (abdomen) with each dose. Do not inject EGRIFTA ® into scar tissue, bruises or your navel.

These are not all the possible side effects of EGRIFTA ®. For more information, ask your healthcare provider or pharmacist.

EGRIFTA ® may cause serious side effects including:

Manufactured by: Jubilant HollisterStier General Partnership, 16751 Trans-Canada Highway, Montreal, Québec, Canada H9H 4J4

• Serious allergic reaction. Some people taking EGRIFTA ® may have an allergic reaction. Stop using EGRIFTA ® and get emergency help right away if you have any of the following symptoms: • a rash over your body • shortness of breath or trouble breathing • hives • fast heartbeat • swelling of your face or • feeling of faintness throat or fainting

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to 1-844-EGRIFTA (1-844-347-4382).

toll-free at

For more information about EGRIFTA ®, go to www.EGRIFTA.com or contact toll-free at 1-844-EGRIFTA (1-844-347-4382). ®

Distributed by: Theratechnologies Inc., 2015 Peel Street, Montreal, Québec, Canada H3A 1T8.

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hile Batman and Superman have been busy battling it out at the box office, another pair of heroes has returned to the scene to save the day. Neil Tennant and Chris Lowe – better known as Pet Shop Boys – can't exactly leap tall buildings in a single bound and they don't own a utility belt full of cool gadgets (that we know of), but what they do have is a brand new album that's not just good, it's bulletproof! Super marks the 13th record by the dynamic duo and their second one with mega-producer Stuart Price; a smart choice considering that the last time these three EDM geniuses got together for 2013's Electric, the result was... well... electrifying. While the boys from Britain haven't exactly basked in the glow of the mainstream spotlight since the mid ‘80s, they've remained a staple on International dance charts and DJ sets worldwide for over three decades. One of the things that have kept PBS on the radar for so long is their quirky view of the world that's at once surreal and relatable. Mash up their witty storytelling with some synth-pop melodies and you've got a formula that's kept these guys relevant way into their golden years. With their latest incarnation, it doesn't look like their tenure as the Professors of Dance Pop will be ending anytime soon either. Right from the gate, the Super session explodes with the high-energy (and somewhat country-fied) opener "Happiness." Featuring nothing more than a catchy hook repeated over techno-house beats, it's everything we need to prepare for the dance floor roller coaster ahead. And really, what queen

can resist singing along to the lyrics "I'm gonna get that boy the only way I know?" To pick a favorite track from this decadent set would be like choosing a favorite friend-with-benefits. They are all flawless in their own way, yet each one has that special something that sets him... I mean... it apart from the rest. The upbeat lead single "The Pop Kids" unfolds with the tale of two old friends reminiscing about their club days to a ‘90s house riff, while "Twenty-Something" takes a stab at entitled millennials armed with an unexpected electro-reggaeton rhythm. "Groovy," "Burn," "Undertow" and "Say It To Me" are the hardcore anthems that bring the heart, passion and BPM to this party leading up to the apropos closer "Into Thin Air." Just like trends in fashion and design, music styles have a way of coming back in vogue eventually. What you'll enjoy most about Super is the subtle essences of PSB classics like "What Have I Done To Deserve This," "Always On My Mind" and "It's a Sin" sprinkled into the fold here and there. Tennant and Lowe could've easily produced a more literal throwback record mimicking their 1986 debut Please, but instead chose to remain forward-thinking while still keeping the door to the past slightly ajar. After 50 million records sold, 22 Top 10 hits, three BRIT awards, six Grammy nominations and a spot in the Guinness Book of World Records as the "Most Successful Duo in UK Music History," Pet Shop Boys have proven once again that EDM can flex its digital muscles and still have a soul. Super might have been an exaggerated moniker for a less-seasoned act, but in this case it is spot on.

If you’re a recording artist, producer or musician and would like your work featured in TOP TRAX, hit me up at abarrios@wiremag.com.

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