Wire Magazine 25 2016 Model Sergey Boytcov Through The Lens Of David Vance

If you’re living with HIV, you may face another clinical challenge to healthy aging

Help Curb Excess Abdominal VAT Visceral adipose tissue (VAT) isn’t regular fat. VAT is a hard fat that surrounds organs, may be associated with serious health issues, and can be difficult to control with diet and exercise alone.

EGRIFTA ® (tesamorelin for injection) is the only FDA-approved treatment for excess HIV-related abdominal VAT EGRIFTA ® was shown to reduce VAT in 2 clinical trials of 816 total adult patients who received 2 mg of EGRIFTA ® or placebo (26-week Main Phase and 26-week Extension Phase).a Trial 1: 18% average reduction. Trial 2: 14% average reduction.

For additional trial details, see the full Prescribing Information at EGRIFTA.com.

a

EGRIFTA® is not indicated to treat health issues beyond the reduction of excess abdominal VAT.

SELECTED RISK INFORMATION What is EGRIFTA ®?

• EGRIFTA ® is an injectable prescription medicine to reduce the excess in abdominal fat in HIV-infected patients with lipodystrophy. The impact and safety of EGRIFTA ® on cardiovascular health has not been studied.

• EGRIFTA ® is not indicated for weight loss management.

• It is not known whether taking EGRIFTA ® helps improve compliance with anti-retroviral medications.

EGRIFTA ® may cause serious side effects including: • Serious allergic reaction. Stop using EGRIFTA ® and get emergency help right away if you have symptoms such as a rash over your body, hives, shortness of breath or trouble breathing, swelling of your face or throat, fast heartbeat, and feeling of faintness or fainting.

• Swelling (fluid retention). EGRIFTA ® can cause swelling in some parts of your body.

• Increase in glucose (blood sugar) intolerance and diabetes.

• Injection site reactions. Change (rotate) your injection site to help lower your risk for injection site reactions. The following symptoms around the area of the injection site can occur: redness, itching, pain, irritation, bleeding, rash, and swelling.

The most common side effects of EGRIFTA ® include: joint pain, pain in legs and arms, swelling in your legs, muscle soreness, tingling, numbness and pricking, nausea, vomiting, rash, and itching.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Please see brief summary of full Important Patient Information on next page.

Learn more at EGRIFTA.com

A Transformation From Within

IMPORTANT PATIENT INFORMATION The following is a brief summary only. See complete Prescribing Information at EGRIFTA.com or request complete Prescribing Information by calling 1-844-347-4382. This information does not take the place of talking to your doctor about your medical condition or your treatment.

What is EGRIFTA ® (tesamorelin for injection)?

• EGRIFTA ® is an injectable prescription medicine to reduce the excess in abdominal fat in HIV-infected patients with lipodystrophy. The impact and safety of EGRIFTA ® on cardiovascular health has not been studied.

• EGRIFTA ® is not indicated for weight loss management.

• It is not known whether taking EGRIFTA ® helps improve compliance with anti-retroviral medications.

Do not use EGRIFTA ® if you: • have pituitary gland tumor, pituitary gland surgery or other problems related to your pituitary gland.

• have active cancer or are receiving treatment for cancer • are allergic to tesamorelin or mannitol.

• are pregnant or become pregnant. If you become pregnant, stop using EGRIFTA ® and talk with your healthcare provider.

Talk to your doctor to find out if EGRIFTA ® is right for you.

How should I use EGRIFTA ®?

• Swelling (fluid retention). EGRIFTA ® can cause swelling in some parts of your body. Call your healthcare provider if you have an increase in joint pain, or pain or numbness in your hands or wrist (carpal tunnel syndrome).

• Increase in glucose (blood sugar) intolerance and diabetes.

Your healthcare provider will measure your blood sugar periodically.

• Injection-site reactions. Change (rotate) your injection site to help lower your risk for injection-site reactions. Call your healthcare provider for medical advice if you have the following symptoms around the area of the injection site: • redness • bleeding • itching • rash • pain • swelling • irritation The most common side effects of EGRIFTA ® include: • joint pain • nausea • pain in legs and arms • vomiting • swelling in your legs • rash • muscle soreness • itching • tingling, numbness and pricking

• Read the detailed “Instructions for Use” that comes with EGRIFTA ® before you start using EGRIFTA ®. Your healthcare provider will show you how to inject EGRIFTA ®.

• Use EGRIFTA ® exactly as prescribed by your healthcare provider.

• Inject EGRIFTA ® under the skin (subcutaneously) of your stomach area (abdomen).

• Change (rotate) the injection site on your stomach area (abdomen) with each dose. Do not inject EGRIFTA ® into scar tissue, bruises or your navel.

These are not all the possible side effects of EGRIFTA ®. For more information, ask your healthcare provider or pharmacist.

EGRIFTA ® may cause serious side effects including:

Manufactured by: Jubilant HollisterStier General Partnership, 16751 Trans-Canada Highway, Montreal, Québec, Canada H9H 4J4

• Serious allergic reaction. Some people taking EGRIFTA ® may have an allergic reaction.

Stop using EGRIFTA ® and get emergency help right away if you have any of the following symptoms: • a rash over your body • shortness of breath or trouble breathing • hives • fast heartbeat • swelling of your face or • feeling of faintness throat or fainting

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to 1-844-EGRIFTA (1-844-347-4382).

®

toll-free at

For more information about EGRIFTA ®, go to www.EGRIFTA.com or contact toll-free at 1-844-EGRIFTA (1-844-347-4382). ®

Distributed by: Theratechnologies Inc., 2015 Peel Street, Montreal, Québec, Canada H3A 1T8.

EGRIFTA® and EGRIFTA ASSIST ® are registered trademarks of Theratechnologies Inc. © 2016 Theratechnologies Inc. All rights reserved. 190-01-12/15

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