VylineV

CRITICAL CARE RANGE

vyline V A pre-assembled infusion set for vasoactive drugs

vyline V

A GAME-CHANGING INNOVATION FOR VASOACTIVE DRUG MANAGEMENT

WHAT ARE THE COMPONENTS OF vyline V ?

vyline V is a pre-assembled infusion set designed to optimise the administration of vasoactive drugs.

DOUBLE-LUMEN octopus WITH bionector

vyline V was designed to address the current issues raised by healthcare professionals working in intensive care units (ICUs). Specifically targeting the challenges associated with haemodynamic instability in critically ill patients linked to the fluctuations of drug delivery during catecholamine syringe relays.

Vasoactive drugs can be difficult to infuse and carry a heightened level of risk due to their strict intravenous administration requirements, short half-life, and narrow therapeutic index. Maintaining a constant flow rate is imperative and requires the use of electric syringe drivers, which inherently limit the volume and result in frequent syringe relays. The relay procedures themselves pose a significant risk of causing haemodynamic instability1 - which has been reported in up to one-third of relays2-8. Any undesired changes in flow rates can also lead to acute and potentially life-threatening changes in mean arterial pressure (MAP)2.

octopus is lightweight and takes up little space Greater patient comfort Less risk of kinking the extension line Possibility to connect an additional line, if needed

vyline V presents an innovative solution in the form of a pre-assembled line. It incorporates polyethylene extension lines, two octopus with bionector needle-free connectors, and anti-return valves—all thoughtfully designed to minimise dead volume in the line and improve drug management.

Remote safe handling (relay away from the patient) Easy line recognition Cleaner, less stressful environment Continuous access to the line Continuity of infusion circuit during the relay time No bolus or delay in administration of catecholamines ➜ hemodynamic stability

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vyline V NEEDLEFREE CONNECTOR - bionector

LABELS FOR IDENTIFICATION OF LINES

• Neutral flush on disconnection = 0 bolus / 0 aspiration (no displacement of liquid) • Closed system preventing bacterial contamination and air ingress • Little or no dead space in the fluid pathway - low priming volume of 0.03ml • Easy disinfection thanks to the cleanable membrane • Effective microbial barrier (supported by numerous microbiological studies which conclude that microbial ingress does not occur)7, 8, 9, 10 • Can stay in place up to 7 days.

• Easy identification of the lines close to the patient • Self-adhesive • Paper, possibility to write the name of the drug on the label • Purple = international colour code for catecholamines

Norepinephrine G5%

NON-RETURN VALVE • Anti-return function: ensuring absence of fluid backflow • Guarantees constant flow of drugs to patient

POLYETHYLENE (PE) EXTENSION LINES • Rigidity of the line No deformation under the effect of pressure No change in flow rate / zero bolus • Internal diameter of extension lines = 1mm, ideal diameter for drugs that need to be administered at a slow and constant flow rate • Available in 2 lengths – 1m50 and 2m

Haemodynamic stability

in the patient, very low dead volume in the line = no bolus or delay in administration of catecholamines

Low consumption of medical devices €€€ savings

Handling far from the patient

the octopus at the end of the line allows for the syringe relay to happen smoothly

Low environmental impact

can stay in place 7 days, reduced packaging, less medical devices required.

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A pre-assembled line

easy to understand and identify

Saves time

extension lines primed in advance

Secure

margin of error removed by no longer using stopcocks

Low risk of infection

line protected with needle-free connectors

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vyline V

AN ADAPTABLE, READY-FOR-USE SYSTEM - ADD ONLY WHAT IS NEEDED

LESS PLASTIC WASTE A pre-assembled set in a single package contributes to reducing environmental impact by minimising plastic consumption associated with individually packaged medical devices used to assemble an infusion line.

4 products in 2 different lengths (150 and 200cm)

PRODUCT DEMO

(setup and syringe relay)

vyline V3

vyline V4

Scan me!

ORDERING INFORMATION

vyline V1

vyline V2

150 cm

200 cm

vyline V1

V03772328

V03772323

vyline V2

V03772325

V03772322

vyline V3

V03772327

V03772326

vyline V4

V03772321

V03772324

vyline V5

V03772343

V03772344

vyline V5 6

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02/2024 - DB VYLI 21 601 E - V2 References: 1. Martin Cour, Thomas Bénet, Romain Hernu, Marie Simon, Thomas Baudry, Philippe Vanhems and Laurent Argaud. Predictors of haemodynamic instability during the changeover of norepinephrine infusion pumps 2. Kato R, Pinsky MR. Personalizing blood pressure management in septic shock. Ann Intensive Care. 2015;5:41.

3. Argaud L, Cour M, Martin O, Saint-Denis M, Ferry T, Goyatton A, et al. Changeover of vasoactive drug infusion pumps: impact of a quality improvement program. Crit Care. 2007;11:R133.

4. de Barbieri I, Frigo AC, Zampieron A. Quick change versus double pumping while changing the infusion of inotrope. Nurs Crit Care. 2009;14:200–6.

5. Morrice A, Jackson E, Farnell S. Practical consideration in the administration of intravenous vasoactive drugs in the critical care setting. Part II— how safe is our practice?

Intensive Crit Care Nurs. 2004;20:183–9 6. Cour M, Hernu R, Bénet T, Robert JM, Regad D, Chabert B, et al. Benefits of smart pumps for automated changeovers of vasoactive drug infusion pumps: a quasiexperimental study. Br J Anaesth. 2014;111:818–24.

7. Arino M, Barrington JP, Morrison AL, Gillies D. Management of the changeover of inotrope infusions in children. Intensive Crit Care Nurs. 2004;20:275–80.

8. Greau E, Lascarrou JB, Le Thuaut A, Maquigneau N, Alcourt Y, Coutolleau A, et al. Automatic versus manual changeovers of norepinephrine infusion pumps in critically ill adults: a prospective controlled study. Ann Intensive Care. 2015;5:40.

9. Food and Drug Administration Agency (FDA), ‘Guidance for Industry and FDA staff’: Pre-market notification submissions, Microbial Ingress Testing, section 8, page 9, July 11th 2008.

10. William R. Jarvis, MD, ‘Choosing the Best Design for Intravenous Needleless Connectors to Prevent Bloodstream Infections’. Infection Control Today, July 28th, 2010.

11. Efficacy of the Valve Systems of Needle-Free Closed Connectors, report 67-08, The Health Protection Agency UK, 21st May 2009.

12. An Evaluation of Bionector Microbial Integrity, report 65-07, The Health Protection Agency UK, 28th November 2007.

FOR FURTHER INFORMATION, PLEASE CONTACT: questions@vygon.com

The specification shown in this leaflet are for information only and are not, under any circumstances, of a contractual nature.

VYGON – 5, RUE ADELINE - 95440 ECOUEN - FRANCE RECEPTION: +33 (0)1 39 92 63 63 – SERVICE CLIENTS FRANCE: +33 (0)1 39 92 63 81 EXPORT CUSTOMER SERVICE: +33 (0)1 39 92 64 15

www.vygon.com

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