The Vital Design Studio provides a comprehensive documentation of the design solutions developed during the fall 2021 semester as responses to the needs of the residents of the City Park West neighborhoods in downtown Denver, Colorado. The interdisciplinary studio's four projects place emphasis on identifying and addressing issues found at the intersections of the built environment and health. A dedicated thank you goes out to Louis A. Meilink and Janetann for sponsoring the Vital Design studio and whose continued support made this endeavor possible. We would also like to thank Cheney Bostic, Frank Locantore, and Curt Upton for their mentorship and additionally to all the reviewers who attended critiques and ultimately guided each project to a successful end. Finally, a most dedicated thank you to our professor and educator Kendra Kirchmer as well as every studio participant for their herculean efforts this semester. Congrats to all.