Department of Medicine Annual Report 2014

& Medicine The

Science Art of

D E PA RT M E N T O F M E D I C I N E CHAIRMAN’S REPORT 2014

Table of Contents

Division Reports 20 Cardiovascular 1 Chair’s Message 22 Clinical Pharmacology 2 Division Chiefs 24 Endocrinology, Diabetes, and Metabolism 2 By the Numbers 26 Gastroenterology 3 Administration 28 General Internal Medicine 30 Geriatrics and Palliative Medicine 3 Chief Residents 32 Hematology-Oncology 4 Faculty Highlights 34 Hepatology 8 Clinical & Research Programs 36 Hospital Medicine 38 Infectious Diseases 12 Educational Programs 40 Nephrology and Hypertension 14 Residents & Fellows 42 Pulmonary, Allergy, Critical Care and Sleep 44 Rheumatology and Immunology

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50 Leadership

51 Philanthropy

Editor: Miriam Barros Director, Business Operations Department of Medicine Design, Editorial & Project Management Consulting: Sabia Communications, Inc.

Published by the Chairman's Office of the Department of Medicine of the University of Miami Miller School of Medicine.

All contents, Š2014 University of Miami.

Reproduction in whole or in part without previous written permission by the editor is prohibited.

High Impact Publications

The art of high touch transformational medical research

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er School of Med i c i ne

Chair’s Message The Department of Medicine at the University of Miami Miller School of Medicine is the largest department within the UM Health System, consisting of more than 350 full-time diverse clinical and research faculty from all corners of the world. Cultural awareness is a key priority in our enterprise and we strive to cultivate leadership from traditionally underrepresented minority groups.

The Department of Medicine works tirelessly to uphold our commitment to providing the highest level of patient care and accurately reflecting the demographics of the community we serve. Our goal is to discover new ways of successfully treating patients so that we can transform lives and provide our students with the most cutting-edge educational experience and advanced medical techniques.

The art of medicine is a continuously evolving choreography of science, technique and delivery that entails countless hours of practice and effort to achieve the pinnacle of excellence.

Our world-renowned scientists are recognized for their expertise which often leads to the development of new treatment techniques and break-through technological advancements. Their vast knowledge serves to foster inspiration in medical students, who go on to seek out cures to the most devastating diseases of our time.

Our education and training programs teach our students and future faculty to become exceptional healers and leaders in academic medicine. We are proud of our exceptional faculty, many of whom have received numerous awards for teaching excellence at the local, regional and national levels. The Department of Medicine has a large variety of training programs in Medicine, such as Cardiovascular Disease, Clinical Cardio Electrophysiology, Interventional Cardiology, Heart Failure and Transplant, Endocrinology and Metabolism, Gastroenterology, Geriatric Medicine, Hepatology, Hematology and Oncology, Infectious Disease, Nephrology, Pulmonary Critical Care and Rheumatology.

In addition to being skilled clinicians and exceptional researchers of science, our faculty members also represent themselves through their artistic creativity. This year’s annual report features the breathtaking photography of various faculty members who have so generously shared their medically inspired discoveries and breakthroughs via their art. We have dubbed these faculty members our “Artists in the House.”

The highlights of our accomplishments this year are exemplified by the Cardiovascular Division which offers technologically cutting-edge cardiovascular services as well as the most advanced treatments in general, interventional and electrophysiology cardiology. The Division also makes advanced imaging and diagnostic testing available to its patients. The Divisions of Hematology-Oncology and Endocrinology are home to Andrew Schally, MD, who was awarded the Nobel Prize in Medicine in 1977 for his work on hypothalamic hormones, and is today pioneering new compounds that we hope will one day cure cancer. The Diabetes Research Institute is a world leader whose members work tirelessly towards finding a cure for Type 1 diabetes mellitus.

The Interdisciplinary Center for Stem Cells currently holds the largest number of new discovery approvals from the Food and Drug Administration for the use of mesenchymal stem cells for the treatment of congestive heart disease and depression. Our Gastroenterology Division’s state-of-the-art Crohn’s and Colitis Center is a bastion of research and expertise for our community, whereas the Infectious Disease Division is known both nationally and internationally for their expertise in basic science and clinical research. Most recently, the Infectious Disease Division played a key role as the spread of the Ebola virus became international news.

The Miami Center for AIDS Research (CFAR) at the University of Miami Miller School of Medicine is the first NIH-funded AIDS research center in Florida. Through our HIV/AIDS research, we are working on a cure agenda focused on prevention research and novel treatment interventions.

The University of Miami is committed to transforming lives every day by enhancing the health of our patients and by providing world-class, quality patient care and education through the constant discovery of new and exciting medical knowledge.

Roy E. Weiss, MD, PhD Professor of Medicine Chair, Department of Medicine University of Miami Miller School of Medicine

Transforming lives daily D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

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Division Chiefs Division chiefs from left to right, top: Joseph D. Rosenblatt, MD, Hematology-Oncology; Paul Martin, MD, Hepatology; Matthias A. Salathe, MD, Pulmonary, Allergy, Critical Care and Sleep; Alejandro Ayala, MD, Interim Chief, Endocrinology, Diabetes, and Metabolism; Richard A. Preston, MD, Clinical Pharmacology; Efren Manjarrez, MD, Interim Chief, Hospital Medicine; Oliver Lenz, MD, Interim Chief, Nephrology and Hypertension; Bottom: Michael Kolber, MD, Vice Chair for Clinical Affairs, Olveen Carrasquillo, MD, General Internal Medicine; Mario Stevenson, MD, Infectious Diseases; Maria T. Abreu, MD, Gastroenterology; Roy E. Weiss, MD, PhD, Chair, Department of Medicine; Hermes Florez, MD, Interim Chief, Geriatrics and Palliative Medicine; Eric Greidinger, MD, Rheumatology and Immunology and Robert C. Hendel, MD, Interim Chief, Cardiology.

Extraordinary people, extraordinary achievements

BY THE NUMBERS CLINICAL ACTIVITY (PER YEAR) PROCEDURES

ADMISSIONS

University of Miami Hospital (UMH)

21,094 UMH 1,576 UMHC/SCCC 4,306 VA 607 Medical ICU 39,819 JMH

1,944 Catheterization (diagnostic) 4,228 Gastroenterology University of Miami Hospital and Clinics UMHC)/ Sylvester Comprehensive Cancer Center (SCCC)

4,209 Endoscopies 90 Bronchoscopies Veterans Affairs (VA)

3,979 Endoscopies (about 75% Colonoscopies)

130 Bronchoscopies 550 Cardiac Catheterizations OUTPATIENT

98,872 UMH 357,061 UMHC/SCCC 123,000 VA (Primary Care) 47,304 Specialty Care 2

TRANSPLANTS (including Pediatrics)

307 Kidney 124 Liver 14 Pancreas 11 Kidney/Pancreas 23 Intestine 17 Heart 3 Lung

29,234 11,079 62 New Patient Visits

Inpatient Admissions

$

MILLION

Total Grant and Contract Revenue

13 350 382

Divisions in the Department of Medicine

Faculty

Residents and Fellows

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

Administration From left to right, top: Marilyn Glassberg, MD, Vice Chair for Innovation & Diversity; Michael Kolber, MD, Vice Chair for Clinical Affairs; Thomas Hooton, MD, Chief of Medicine, Miami VA; Matthias Salathe, MD, Vice Chair for Research; Stefanie Brown, MD, Vice Chair for Education.

Bottom: Anna C. Herman-Giddens, Vice Chair; Miriam Barros, Director, Business Operations; Roy E. Weiss, MD, PhD, Chairman, Maritza Suarez, MD, Associate Vice Chair, Quality; Jennifer Marks, MD, Vice Chair for Appointments & Promotions.

Chief Residents From left to right: Julian L. Watkins, MD Amelie Muse Romelus, MD, MHA Stacy Rubin, MD; Alexandria Beranger, MD Roy E. Weiss, MD, PhD, Professor and Chairman, Department of Medicine Andrew DeNicco, MD Mario C. Ponce Alvarez,MD Joslyn Wiley, MD

RVUS

$

MILLION

Total NIH Revenue

Active Awards

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

$120 100 MILLIONS OF DOLLARS

757,138 29.7 253

TOTAL REVENUE FROM THE DEPARTMENT OF MEDICINE

80 60 40 20 0 FY 2010

FY 2011

FY 2012

FY 2013

FY 2014

138,259 Outpatient Visists

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Faculty Highlights The University of Miami Miller School of Medicine has truly exceptional faculty who are on the cutting edge of technological research in their field. Here are some outstanding examples.

ALLEN ANDRADE, MD, secured $190,000 in funding for his one year study to deliver and evaluate selfmanagement skills training to geriatric veterans with urinary incontinence and overactive bladder. Among the skills taught to the veterans are individualized patient education and behavioral therapy.

SCHARTESS CULPEPPER-PACE, MD, is a clinical investigator with an interest in materno-fetal medicine in rheumatology. A Florida native who is a former Jackson/University of Miami trainee, Dr. CulpepperPace completed her rheumatology fellowship at Emory University. She became interested in rheumatology early in her medical career due to the complexity of the conditions seen in patients as well as the emerging insights and treatment options developing in the area of inflammatory diseases. Although Dr. CulpepperPace takes an interest in all rheumatic/inflammatory conditions, her particular interest focuses on autoimmune processes in women. In addition to seeing patients at the main UM medical campus, Dr. Culpepper-Pace works at UM’s newest rheumatology satellite practice in Kendall.

ORIANA DAMAS, MD, is the newest member of the GI team, having joined in 2014.

Among other notable accolades, Dr. Damas was recently honored with the prestigious Dr. Martin H. Kalser Fellowship Award for her dedication to the study, teaching and research of gastroenterology.

Her research on inflammatory bowel disease (IBD) focuses on identifying the contributions of genetic and environmental factors in the development of IBD in immigrant Hispanics. She has compared the genetic loads of Hispanics and non-Hispanics to determine how these two groups differ in their genetic susceptibility to IBD. She also examines the dietary changes of Hispanic immigrants to the general US population to identify the key triggers that may play a role in disease onset.

Ultimately, Dr. Damas’ goal is to identify the various factors that contribute to the development of this disease in immigrant Hispanics, a rising population of IBD sufferers in South Florida.

A Miami native, Dr. Damas received her medical degree from the University of Miami Miller School of Medicine and continued her training in Internal Medicine and Gastroenterology at Jackson Memorial Hospital/ University of Miami Miller School of Medicine.

STUTI DANG, MD, in collaboration with the Tampa VA Healthcare System, was provided with $171,000 in funding for her one year project which involves evaluating the benefits of integrating home tele-health with homebased primary care.

YVONNE DIAZ, MD, Chief Academic Officer for UHealth, and Joan St. Onge, MD, Associate Dean for Graduate Medical Education (GME), continue to provide outstanding leadership for UHealth. One example of their bold management is the launching of Multi-Specialty Learning Communities, where UM faculty meet with about 8-10 interns in a small group setting to address common challenges encountered in residency.

GUSTAVO FERNANDEZ, MD, completed an executive MBA in health sector management and policy at the University of Miami School of Business in 2010 and has applied Six Sigma methodology to improve the cancer patient experience.

Dr. Fernandez and his hospital team won a prize in May 2014 at the annual Florida Sterling Conference Team Showcase for a project that decreased patient wait time at an infusion unit. In October 2014, Dr. Fernandez’s efforts were again recognized as “Innovation of the Year in Patient Care” by the Florida Hospital Association for decreasing laboratory wait time.

Gustavo Fernandez, MD, and Members of ‘Team CTU’

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Faculty Briefs Dr. Fernandez has also worked with Divisional Administrator Susan Martin, and the Division Chief to develop an effective incentive policy for faculty and to boost productivity in an academic environment. Dr. Fernandez has been appointed Associate Chief Medical Officer at the Sylvester Comprehensive Cancer Center in recognition of his efforts.

HERMES FLOREZ, MD, was appointed Director of the Geriatrics Research, Education, and Clinical Center (GRECC) at the Miami Veterans Affairs (VA) Healthcare System. Together with other Division faculty, Dr. Florez provided information on best practices for geriatrics during a recent visit by members of the European Union.

His team also evaluated 10,000 participants in the Million Veterans Program (MVP) as part of the VA genomics initiative.

LILLIAM GUZMAN, MD, FACP serves as Medical Director of the International Medicine Institute and was recently presented with the Top 10 Doctors Award, the Patient’s Choice Award, and the Most Compassionate Physician Award. Dr. Guzman recently developed the Executive Physicals Program and is developing additional prepaid packages catering to UHealth’s international clientele.

MICHAEL KOLBER, MD, PhD, and Susanne DobleckiLewis, MD, have spearheaded a program that uses antiretrovirals to prevent HIV infection. One important study currently underway is the NIAID funded PreExposure Prophylaxis Demonstration Project. It has been well established that transmission of HIV can be virtually eliminated when those at risk take an FDA approved antiretroviral combination. This is known as pre-exposure prophylaxis. Before the FDA approved the drug however, it stated that more research was needed. It was because of this that the University of Miami Team under Dr. Kolber partnered with Grant Colfax, MD, in San Francisco (exDirector of the Office of National AIDS policy) to evaluate whether those at risk would take the medication as prescribed. The answer to this question will determine whether such an intervention will ultimately decrease the transmission of HIV in high-risk populations.

PAUL MARTIN, MD, serves as Chair for Gastroenterology at the American Board of Internal Medicine (ABIM) and sits on its Council. He also co-directed the Annual Postgraduate Course of the American Association for the Study of Liver Disease last fall.

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

CARDIOVASCULAR Nanette Bishopric, MD, was elected to the Association of University Cardiologists this year. She continues to examine basic mechanisms of cardiac hypertrophy and the regulation of heart growth.

Sandra Chaparro, MD, became the first clinician to implant the CardioMEMS device in a patient with heart failure to continuously track left ventricular filling so as to optimize outpatient management.

Joshua Hare, MD, Founding Director of the Interdisciplinary Stem Cell Institution, along with Alan Heldman, MD, Director of Interventional Cardiology, has published a series of papers outlining how intracardiac injections of stem cells promotes improved heart function. Their work also highlights the impact of imaging on stem cell research.

Robert Hendel, MD, was recently named Interim Chief of the Cardiovascular Division. Earlier this year, he was elected to a five-year term as Trustee of the American College of Cardiology. Dr. Hendel has also met with members of Congress and the Director of CMS to discuss the appropriate use of cardiovascular technology.

Robert Myerburg, MD, former Chief of the Division, continues to advance research, clinical care and education with his focus being genetics and heart disease. He is currently serving on the Institute of Medicine committee on Treatment of Cardiac Arrest: Current Status & Future Directions.

ENDOCRINOLOGY, DIABETES, AND METABOLISM Andrew Schally, MD, was awarded the Nobel Prize in Medicine in 1977 for his work on hypothalamic hormones. He also developed the present therapy for men with advanced hormone-dependent prostate cancer.

GASTROENTEROLOGY Jamie Barkin, MD, was selected by the Board of Trustees of the American College of Gastroenterology Awards Committee to receive the College’s 2014 Samuel Weiss Award. The criteria used in judging for this prestigious award focuses on the outstanding contributions of an individual to the ACG. Amar Deshpande, MD, will begin a new role as Assistant Dean for Medical Education and Competency Assessment.

GENERAL INTERNAL MEDICINE Alex Mechaber, MD, oversees all teaching for medical students as Senior Associate Dean for Medical Education for undergraduate medical education. Among his important achievements, he successfully led our school’s re-accreditation process in 2012.

Maritza Suarez, MD, serves as the Associate Chief Medical Information Officer and helps oversee UChart optimization for UHealth. Given her strong background in engineering and quality control for systems, she was recently promoted to Associate Vice Chair for Quality in the Department of Medicine.

Leonardo Tamariz, MD, MPH, has reshaped the Veteran Affair’s IRB into a highly functional process over the last three years. In addition, he leads the increasingly popular Resident Scholarly Activity Program (RSAP).

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Faculty Briefs

Faculty Highlights

HEMATOLOGY-ONCOLOGY

JAIME MERCHAN, MD, has pioneered new approaches for

Jonathan Trent, MD, Director of the Sarcoma Medical Research Program and Co-Director of the Musculoskeletal Center has presided over the rapid expansion of clinical activities in sarcoma. Dr. Trent won the Outstanding Care Award, bestowed by the Sarcoma Alliance, and is the only physician so honored in the United States.

the treatment of renal cell carcinoma and has initiated trials using novel virally-based oncolytic vectors developed at UM by Glenn Barber PhD., in patients with metastatic head and neck cancer. Dr. Merchan was recently appointed co-leader of the Experimental Therapeutics Program at the Sylvester Comprehensive Cancer Center.

HEPATOLOGY A lecture on Hepatocellular Carcinoma was presented by Ram Bhamidimarri, MD, at Digestive Diseases Week in May and he also edited an issue of Clinics in Liver Disease on liver transplantation.

Cynthia Levy, MD, serves on the Education Committee of the American Association for the Study of Liver Disease.

INFECTIOUS DISEASES Margaret Fischl, MD, plays a central role in the NIH AIDS Clinical Trials Group (ACTG) programs. Dr. Fischl also serves as the Miami P.I. on the NIH Miami Women’s Interagency HIV Studies V (WIHS).

Dushyantha Jayaweera, MD, is the Associate Vice Provost for Human Subjects Research. Under his watch, UM’s Human Research Protection Program is seeking accreditation by the Association for the Accreditation of Human Subject Programs (AAHRPP).

Allan Rodriguez, MD, is a Professor of Clinical Medicine and has extensive clinical experience dealing with disadvantaged populations.

Dr. Rodriguez currently coordinates physician services and oversees the clinic support staff.

Mario Stevenson, MD, is developing novel inhibitors of HIV infection and transmission and is attempting to understand how HIV is able to persist despite antiretroviral therapy.

Stephen Symes, MD, is the Assistant Dean for Diversity and Multicultural Affairs and Program Director for the Internal Medicine Training Program.

NEPHROLOGY AND HYPERTENSION Alessia Fornoni, MD, PhD., who holds the Peggy and Harold Katz Family endowed chair, directs the Peggy and Harold Katz Family Drug Discovery Center, and is the Division’s Research Director. An accomplished investigator with an interest in diabetic and other kidney diseases, Dr. Fornoni serves in leading roles on various national and international committees and initiatives, and has contributed to more than 70 high-impact publications. Dr. Fornoni was also invited to become a member of the prestigious Glomerular Disease Advisory Board at the American Society of Nephrology, and joined the Editorial Board of the scientific journal Diabetes. Pilot grants were awarded by the Clinical and Translational Science Institute to her in 2013.

Oliver Lenz, MD, MBA, is leading the Division as Interim Chief. Prior to his appointment, Dr. Lenz served as the Nephrology Training Program Director, and during his tenure the training program achieved full accreditation by the Accreditation Council for Graduate Medical Education (ACGME). Dr. Lenz also served on the American Society of Nephrology’s Training Program Director’s Executive Committee and has authored and co-authored more than 50 peer-reviewed articles.

As an accomplished clinical educator, Dr. Lenz provides patient care and clinical training in general nephrology.

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CARL ORRINGER, MD, is a recent addition to the faculty spearheading new initiatives for the management of complex lipid disorders, including heading the LDL Apheresis Program. He is the president-elect of the National Lipid Association.

ANA PALACIO, MD, Associate Professor of Medicine and Public Health, currently focuses on patients’ adherence to their medication usage. This past year, Dr. Palacio began important research collaborations with Ecuador, helping physicians in her native country develop sufficient research capacity among the faculty at universities throughout the country.

SHIRIN SHAFAZAND, MD, is committed to conducting patient-oriented research in sleep medicine. As the Principal Investigator for an American Sleep Medicine Foundation grant exploring the prevalence of sleep disorders in Hispanic patients, she also studied sleep disordered breathing (SDB) and its treatment in patients with Parkinson’s Disease.

Dr. Shafazand also studies the impact of SDB on cholesterol, and the metabolic profile in patients with spinal cord injury (SCI). She is the Principal Investigator of a current trial on sleep apnea.

Dr. Shafazand is actively involved with the Sleep Respiratory and Neurobiology Journal club, and serves as Chair of Sleep Education. Additionally, she is the associate editor of two prominent Sleep and Pulmonary/ CCM journals.

RAKESH SINGAL, MD, has initiated several unique trials in metastatic prostate cancer based on the combining of standard chemotherapy with epigenetic modifiers such as Vidaza to overcome chemotherapy resistance . He recently received a State of Florida Bankhead Coley Award in support of his efforts.

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Faculty Briefs JAY SKYLER, MD’s current research focus is on Type 1 diabetes. Beginning in the 1980s, he and his colleagues conducted some of the first research using immune intervention. Later, Dr. Skyler designed and served as Study Chairman for the nationwide NIH-sponsored Diabetes multicenter. He is a past President of the American Diabetes Association and served as VicePresident of the International Diabetes Federation. A frequent national and international lecturer, Dr. Skyler has authored, edited and co-edited numerous books, chapters and articles; and was founding Editor-in-Chief of Diabetes Care.

JOYCE SLINGERLAND, MD, director of the Braman Breast Cancer Institute and MARC LIPPMAN, MD, Deputy Director of the SCCC, continue ground-breaking breast cancer research efforts. Dr. Slingerland is studying the role of obesity-related inflammation in breast cancer. The Lippman laboratory has developed a unique mouse model that allows simultaneous analysis of changes in gene expression within stroma and in cancer cells. This model helps study the influence of the microenvironment in promoting the growth of breast cancer. Dr. Lippman is the recipient of a Breast Cancer Research Foundation Award for these research efforts.

KHIN ZAW, MD, received approval from the Hospice and Palliative Medicine Fellowship Training Program, becoming its founding director and enhancing the palliative care program at UMH (Vitas Hospice Inpatient Unit) and Sylvester Comprehensive Cancer Center.

JESSICA ZULETA, MD, FHM, created the curriculum at the University of Miami Hospital site in 2010, as an Assistant Program Director for the internal medicine residency program. During her advanced training at the University of North Carolina at Chapel Hill’s Faculty Development Program from 2005-2007, Dr. Zuleta learned to become a medical educator. She became proficient at understanding how to develop curricula for medical education, as well as teaching at the bedside, and providing feedback to her students in a constructive and educational way.

Serving as Director of the Division of Hospital Medicine’s Faculty Development Series, Dr. Zuleta provides junior faculty with advice on how to be successful teachers. Her goal is for the faculty members to receive the highest teaching scores from their students and more often than not, they do.

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

Sandra Merscher, PhD, and Christian Faul, PhD, were recipients of the prestigious institutional Glaser Award in 2013 and 2014, respectively. This award supports junior investigators as they work to secure federal funding. Remarkably, all investigators at the Division have received this award at some point in their career.

David Roth, MD, the Division’s Clinical Director, has spent more than 30 years at the University, during which he served as Training Program Director and Division Chief. Dr. Roth plays a pivotal role in the training of nephrology fellows and has an active research interest focusing on immunosuppressive protocols in kidney transplantation. He also investigates the impact of hepatitis C virus infection in kidney transplant candidates and recipients, and serves as the United Network for Organ Sharing (UNOS) Medical Director for kidney transplantation at the Miami Transplant Institute.

Ivonne Schulman, MD, is both an experienced clinical educator with expertise in all aspects of general nephrology and an accomplished investigator with a focus on the role of stem cells in cardiovascular and kidney diseases. Currently serving as Training Program Director, Dr. Schulman has led the program through the transformative changes brought on by the Accreditation Council for Graduate Medical Education’s (ACGME) next generation accreditation system. Dr. Schulman, along with Dollie F. Green, MD, and Oliver Lenz, MD, received generous philanthropic support that will help enhance the research and educational missions of the Division.

PULMONARY, ALLERGY, CRITICAL CARE AND SLEEP Michael Campos, MD, conducts multi-center clinical trials with the largest cohort of alpha 1 antitrypsin deficient patients in the United States and regularly serves on study sections for the Alpha-1 Foundation.

Tanira Ferreira, MD, has implemented multidisciplinary rounds and created numerous protocols to improve survival in the medical ICU. She is the interim CMO of the University of Miami Hospital.

Marilyn Glassberg, MD, is a national leader in the translation of stem cell research and is conducting trials in patients. She is also the recipient of a National Library of Medicine Award.

Andreas Schmid, MD, conducts multi-center trials with bronchiectasis patients and has an NIH-funded basic science effort to better understand airway epithelial differentiation.

The Division has three dedicated Critical Care Specialists: Daniel Kett, MD, researches invasive fungal infections and Intensive Care Unit infection control. He serves as chair of the University’s IRB-C. Andrew Quartin, MD, MPH, serves as the lead investigator on a clinical effectiveness project comparing antifungal therapies, serves on the Infection Control Committee and chairs the Cardiopulmonary Resuscitation committee.

Roland Schein, MD, has extensive research experience in sepsis, respiratory failure and acute kidney injury. He serves on the hospital Ethics Consultation Committee and chairs the Critical Care Committee.

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Clinical & Research Programs The Department of Medicine works diligently to provide the highest quality patient care that accurately reflects the community we serve. Our goal is to discover novel therapies and apply them to our patients so that we can transform lives daily. In addition, our world-renowned scientists, who are recognized for their expertise, often develop new treatment techniques and discover breakthrough technological advancements. Their vast knowledge fosters inspiration in medical students, who go on to seek cures to the most devastating diseases of our time.

FINDING A GENETIC LINK FOR IRRITABLE BOWEL SYNDROME The University of Miami’s Gastroenterology (GI) Research department is committed to supporting Irritable Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS) patients. Currently, the Division is engaged with a large IBD bio-repository study that works with more than 1,600 patients to help identify a genetic link to these diseases and provide early detection and/or prevention. These studies assist patients that have undergone different treatments without success.

MULTIDISCIPLINARY CARE USED AT ALL UM AFFILIATED CENTERS

FROM BENCH TO BEDSIDE IN ADULT LEUKEMIA

The Division of Hematology-Oncology has developed a robust portfolio of clinical trials addressing the needs of patients for whom standard therapy may be inadequate.

The Division provides hematology and oncology care at all University of Miami affiliated hospitals and affiliated outpatient clinics spanning southern Florida from Kendall

in the

Artist House 8

to Deerfield Beach and Coral Springs. Services provided include the provision of consultative hematology-oncology services at the UMHC/Sylvester Comprehensive Cancer Center, UM Hospital, Jackson Memorial Hospital, and the Miami VA Hospital.

The Division’s cancer efforts are integrated into 15 multidisciplinary Site Disease Programs within the Sylvester Comprehensive Cancer Center. These site disease group teams include multidisciplinary physicians who are expert hematologists, medical oncologists, radiation oncologists, pathologists, and surgical oncologists. The supporting research and clinical staff are dedicated to the provision of outstanding multidisciplinary care.

Gustavo Fernandez, MD, Associate Director of Clinical Operations, has dedicated his efforts towards maximizing efficiency and productivity of the faculty in the increasingly complex and challenging modern clinical and academic environment. Dr. Fernandez has implemented a broad array of logistical and process improvements in the inpatient facilities and out-patient oncology infusion units that have markedly increased efficiency and patient, as well as faculty, satisfaction alike.

With the arrival of Stephen Nimer, MD, to serve as the Sylvester Cancer Center Director and the recent recruitment of Ronan Swords, MD, PhD, Arthur Zelent, PhD, and Justin Watts, MD, the adult leukemia program at UM has assumed center stage, expanding in parallel to efforts in stem cell transplantation. The Zelent and Nimer laboratories are leaders in the study of pathogenesis and the development of treatments for acute myelogenous leukemia. Nimer’s recent contributions include elucidating the role of PI3K-Akt pathway in regulating leukemic stem cell maintenance, published in Cell Cycle, and the role of PRMT4 in regulating myeloid differentiation, published in Cell Reports. Drs. Swords and Watts provide expertise in the conduct of Phase I/II clinical trials for the testing of novel approaches in leukemia. Dr. Swords has continued his original studies on Neddylation in AML, and is leading

School of yellow tail basslets in Palau by Marc Lippman, MD, MACP, FRCP, Leonard M. Miller Professor of Internal Medicine, Psychiatry and Behavioral Sciences and Deputy Director, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine

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a promising clinical trial using a Neddylation inhibitor.

Additionally, he has also pioneered a clinical trial based on Zelent’s bench research, using all trans-retinoic acid combined with the anti-depressant Triethyl Cipromine in elderly patients with AML. Dr. Swords is the recent recipient of an Endowed Professorship in Leukemia from the PAP Corps; a 22,000 member volunteer organization that supports research at the Sylvester Comprehensive Cancer Center. Dr. Watts was recently awarded an ASCO Young Investigator Award from the Conquer Cancer Foundation.

WORKING TOGETHER AS ONE COMMUNITY

FOCUSING ON HOSPITALIZED DIABETES PATIENTS

General Internal Medicine faculty have a wide range of research interests, including minority health disparities, health services research, medical education, ethics, diabetes, cardiovascular disease, cancer and stroke.

In 2014, the Division completed the Miami Health Heart Initiative, a clinical trial of 300 poorly-controlled Latino diabetics showing that a community health worker intervention improved blood pressure and glycemic control. Another study followed 400 minority patients nationwide and determined that phone-based interviewing improved the chance that patients would continue to take their medication. Globally, the faculty also participates in research projects in Ecuador, Puerto Rico and the Dominican Republic.

Joshua Lenchus DO, RPh. FACP, SFHM was awarded a grant by the Florida Medical Malpractice Joint Underwriting Association (FMMJUA) for $748,961 to study the effects of simulation-based procedural education on reducing thoracentesis-induced iatrogenic pneumothorax rates. This is in addition to a prior $600,000 grant he received from the FMMJUA two years ago to study simulation in procedure-based competency in medical education.

Efren Manjarrez, MD, is part of a task force convened by the Society of Hospital Medicine to find out the secret to optimal control of diabetes in hospitalized patients.

The American Diabetes Association publishes guidelines on target blood sugar levels and how to attain those levels in medically and surgically unstable patients.

A dedicated multidisciplinary team is focused on inpatient diabetes control and utilizes physician feedback, nursing education, innovative patient education, and good IT infrastructure to create a formula for success.

Another example of efficiency can be seen with the clinical activities taking place at the Infectious Diseases Division under the guidance of Michael Kolber, MD, PhD, Clinical Director of HIV/AIDS and Thomas Hooton, MD, Clinical Director of Infectious Diseases. This revenuecentered Division handles various revenue streams via partnerships with neighboring community-based and health care organizations.

RESEARCH SHOWS HOW TO BEST ENCOURAGE PATIENTS TO TAKE THEIR MEDICATIONS

Successfully bridging the bench to the bedside D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

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Clinical & Research Programs PROVIDING REFERRALS AND CONSULTATION SERVICES

EXPANDING UM’S REACH THROUGHOUT SOUTH FLORIDA

The Division of Infectious Diseases provides inpatient and outpatient consultation on a wide variety of infectious diseases. Common referrals include patients requiring long-term antibiotics for infections of the bone and joint, infections of prosthetic devices, pacemakers, prosthetic heart valves or vascular grafts. Faculty members such as Gordon Dickinson, MD, also provide travel consultation and immunizations, and evaluate patients who may have acquired infectious complications while travelling abroad.

Along with providing world-class medical techniques, offering outstanding clinical care remains one of the core commitments of the Nephrology and Hypertension Division. The faculty sees patients at the University of Miami Hospital and Clinics, Jackson Memorial Hospital, the Miami Veterans Affairs Medical Center, outpatient facilities on campus, as well as in Kendall, Hialeah, and Boca Raton, and in community-based dialysis clinics.

During the past fiscal year, physicians rendered more than 2,300 new and 9,400 follow-up office visits, and provided more than 2,800 consultations and 14,000 follow-up inpatient encounters. They followed more than 400 ambulatory dialysis patients and oversaw more than 2,800 inpatient dialysis treatments.

TACKLING INFECTIONS IN IMMUNOCOMPROMISED PATIENTS The Division has faculty that specializes in the evaluation and treatment of infections occurring in severely immunocompromised patients, such as those receiving solid organ or stem cell transplantation, patients receiving cancer chemotherapy, or those on immunosuppressive medications. Faculty members such as Jacques SimkinsCohen, MD, Lilian Abbo, MD, Jose Camargo, MD, and Michele Morris, MD, provide infectious diseases consultation to the Miami Transplant Institute, one of the busiest transplant centers in the nation.

CARING FOR THE LITTLEST PATIENTS A joint program with the Pediatric Pulmonary Division is focused on children with lung disease. The clinics offer a variety of research opportunities, spanning translational and clinical research. Patient and physician-directed symposiums are offered to provide updated information and access to programs.

USING COLLABORATIVE RESEARCH TO TACKLE DISEASE Stephanie Krick, MD, is a third year Pulmonary/Critical Care fellow with extensive training in pulmonary research both in Germany and in the United States.

An outstanding clinician, Dr. Krick always wanted to become a physician scientist. During her research rotation, she discovered that a molecule, implicated to cause cardiovascular disease in renal failure, seemed to be involved in the development of COPD. Dr. Krick was able to combine research in the Divisions of Nephrology and Pulmonary Diseases to create a collaborative research team with huge translational potential. Emboldened by the promising results, Dr. Krick recently submitted a grant application to obtain funding for this topic.

USING ULTRASOUND AND OTHER CUTTING-EDGE TECHNOLOGY TO IMPROVE PATIENT CARE At the Rheumatology Division, the latest and most technologically advanced musculoskeletal ultrasound machines and trained rheumatology faculty are now available at three clinical sites, Deerfield Beach, Plantation, and the UM Medical Campus, with 10

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

plans for further expansion. Ultrasound not only can guide injections and establish specific diagnoses; the technique also provides important training for fellows to know the relevant musculoskeletal anatomy. Adding musculoskeletal ultrasound services to the rheumatology Division shows the ongoing commitment of the Division of Rheumatology towards maintaining excellence and leadership in rheumatology, in terms of emerging technologies as well as knowledge and clinical skill.

GOING BEYOND KIDNEY TRANSPLANTATION The physicians who staff the Miami Transplant Institute (MTI), made it one of the nation’s busiest and most recognized centers for excellence in kidney transplantation. Operated collaboratively between Jackson Memorial Hospital and the University of Miami Miller School of Medicine, the MTI provided transplantation to more than 300 patients who received kidney or kidney/pancreas transplantations in 2013.

Results during 2014 are on pace to well exceed these numbers. Directly related to the recognition that the center has achieved scientifically on an international level, it has attracted a large number of international patients with proteinuric kidney diseases seeking experimental treatment strategies before and after kidney transplant. An exciting addition to the kidney transplantation program in 2014 was the first paired living donor exchange transplantation performed in the state of Florida. A paired kidney exchange consists of two or more donor/recipient pairs who are not compatible with each other within the pair, but where compatibility exists across pairs. In addition, Adela Mattiazzi, MD, and colleagues have refined the management of highly sensitized recipients, leading to successful transplantations in this otherwise difficult to treat patient group.

Directed by Loay Salman, MD, South Florida’s only academic Interventional Nephrology Program provides comprehensive vascular access care to dialysis patients and trains physicians in endovascular procedures, while also supporting a vibrant, NIH-funded research program.

PROVIDING COMPREHENSIVE, HOLISTIC CARE TO CANCER PATIENTS Groundbreaking research is also taking place within the Pulmonary Division, where Elio Donna, MD, and Gregory Holt, MD, are part of a multidisciplinary team that manages lung cancer. The team meets weekly for case presentations and discussions on management of D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

confirmed cases and screening programs. An early lung cancer screening program has been established and a Lung Nodule Clinic is open for referrals. Collaborations with medical oncologists provide pulmonary evaluations and reviews of chest images after chemotherapy.

Additionally, the team works with nutritionists, physical therapists and social workers to provide comprehensive care. A monthly meeting on the management of lung cancer patients provides community physicians with updates on the latest therapy regimens.

Similarly, the interstitial lung disease program conducts weekly clinics that offer pulmonary consultation for rare and interstitial lung diseases. Additional clinics are dedicated to patients with autoimmune-related lung diseases, an effort led by Dana Ascherman, MD, and Marilyn Glassberg, MD. Another clinic includes patients with pulmonary hypertension and is staffed by Shirin Shafazand, MD, and Sandra Chaparro, MD.

SYLVESTER AFFILIATED CLINICS SERVING THE REGION The Division is proud to have satellite clinics established throughout South Florida that serve the needs of patients.

Each clinic is headed by an exceptional physician who is constantly working towards improving the health of their patients. Mohammad Jahanzeb, MD, director of the Deerfield Beach Clinic, has been a major contributor to the formulation of NCCN Guidelines for the treatment of breast and lung cancer, and was recently elected as Chairman of the American Society of Clinical Oncology Quality Practice Initiative.

Sharhabil Ammus, MD, Frances Valdes Albini, MD, and Lawrence Negret, MD, see a wide variety of patients at the clinic in Kendall, which serves residents of Kendall, Coral Gables and Pinecrest.

Efforts in Broward County are anchored by Ney Alves, MD, Roberto Cano, MD, and Raja Mudad, MD, in Hollywood along with Israel Wiznitzer, MD, and Chukwuemeka Ikpeazu, MD, PhD. in Plantation.

Dr. Mudad’s unique expertise in the application of information technology was critical in helping the Division seamlessly adapt to and integrate Beacon, a new computerized chemotherapy ordering system.

Recent additions include Timothy Aliff, MD, Steven Weiss MD, PhD, and Neil Weinreb, MD, in Coral Springs.

Dr. Weinreb also holds an appointment in Human Genetics and has a unique practice focused on treatment of patients with Gaucher’s and Fabry’s storage diseases.

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Educational Programs The Department of Medicine is proud to train over 250 house staff every year in residency and fellowship programs, the largest group of trainees in any department. House staff is present at almost every institution within the UHealth and Jackson Health Systems. The educational mission is to produce versatile physicians who are astute clinicians, innovative researchers, skilled educators and community leaders with a passion for medicine.

TEACHER OF THE YEAR AWARDED FOR EDUCATIONAL EXCELLENCE Atil Kargi, MD, was named Program Director of the J. Maxwell McKenzie fellowship program and his commitment to educational excellence was recently recognized by the Miller School of Medicine and medical students who bestowed upon him the “Teacher of the Year” award. The Division distinguishes itself by having one of the most diverse, high-volume and multicultural endocrine clinics in the country.

STRONG ACCREDITATION PROGRAM GUIDES STUDENTS TOWARD THEIR FUTURES The training program in Gastroenterology, Hepatology and Nutrition is accredited by the Accreditation Council for Graduate Medical Education (ACGME). Additionally, the program offers three years of formal education designed to qualify the trainees for their Gastroenterology Boards. The training also teaches students to become high-quality consultants and prepares them for the research or educational arenas.

INTERNATIONALLY-RECOGNIZED FACULTY DEDICATED TO THEIR STUDENTS The Division is devoted to educating fellows in the quality care of patients as well as conducting clinical research in disorders of the gastrointestinal tract and liver. It also educates physicians in the diagnosis, management and treatment of patients with gastrointestinal and hepatic disorders. This mission is accomplished by nationally and internationally recognized faculty working together to provide quality and cost-effective patient care and cuttingedge research. Faculty serve as attending physicians who are actively involved in the Gastroenterology fellowship program and educate those seeking a career in this specialty. They have a wide range of special interests, including inflammatory bowel disease, motility disorders, functional bowel disease, gastrointestinal 12

cancer, disorders of the liver and pancreas, therapeutic and advanced endoscopy, hepatology, liver and intestinal transplantation, and other related health care disparities.

LINKING RESEARCH TO CLINICAL PRACTICE WHILE TRAINING THE NEXT GENERATION The Division of Rheumatology has become a leader in bringing research insights into clinical practice, as part of the Evidence-Based Medicine movement. Larry Young, MD, Assistant Professor of Clinical Medicine, Chief of Rheumatology at the Miami VA, and Director of the Vasculitis Clinic, has been promoted to Co-Director of the Program on Teaching Evidence-Based Practice, an annual international conference held at Duke University. Dr. Young is also a named contributor to “The Rational Clinical Examination Education Guides” on JAMAevidence.com.

In this work, Dr. Young performs topic-based literature reviews and analyses to identify approaches to the diagnosis and treatment of rheumatic disease patients that are supported by rigorous research evidence. He then teaches trainees how to read and interpret research reports to assess their level of evidence, and how to bring new insights from research trials into clinical practice.

For years, Dr. Young has been an Associate Director of the Internal Medicine training program in addition to his rheumatology duties. As a beloved and trusted clinician to his patients and confidante to scores of trainees, Dr. Young is following in the path of the first practicing rheumatologist on the UM and Miami VA faculty and former mentor to Dr. Young, Harvey E. Brown, Jr., MD, who passed away in 2012 at age 89 after 55 years on the faculty.

A fund has been established for donors who wish to honor the memory of Dr. Brown, and to support the ongoing commitment of the Division of Rheumatology to medical education.

OUTSTANDING FELLOWSHIP PROGRAMS INSPIRE STUDENTS The Hematology/Oncology Fellowship program offers a diverse clinical and research experience to fellows rotating through JMH, the Miami VA, the UM Sylvester Comprehensive Cancer Center, and the UM Hospital.

In 2014, Judith Hurley, MD, Director of the Jackson Memorial Hematology-Oncology clinic, succeeded Pasquale Benedetto, MD, as fellowship director.

The fellowship experience includes exposure to a U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

wide spectrum of hematologic malignancies, solid tumor oncology and coagulation /thrombotic disorders. The Division also contains a growing number of translationally oriented laboratories that have attracted outstanding post-doctoral fellows as well as research scientists interested in pursuing and furthering academic careers which offer unique opportunities for realization of the trainees’ academic goals.

Trainee matriculation rates and board scores have been excellent and graduates of the Fellowship have successfully pursued outstanding academic careers at a variety of U.S. and Latin American institutions.

OFFERING AN OUTCOME BASED CURRICULUM The Division of Hospital Medicine contributes significantly to the educational mission of the University of Miami Hospital and Jackson Memorial Hospital. At UM Hospital, the Division staffs two internal medicine ward teaching teams. These teams consist of residents and medical students, as well as the Internal Medicine Consult Service directed by renowned Perioperative Medicine guru, Steven Cohn, MD. The outcome based curriculum covers a daily didactic literature review along with pre and post-tests. The program also offers preoperative clinic visits and consults on hospitalized surgical patients.

Similar to its counterpart at UM Hospital, the Internal Medicine Consult rotation at JMH focuses on perioperative medicine and includes consultation on obstetrics, neurology and rehabilitation patients.

ACGME-accredited Internal Medicine residency program is required prior to beginning fellowship training.

The fellowship program provides a comprehensive clinical and academic experience for trainees. Fellows work in inpatient and outpatient settings at private, public, and federal government facilities and become adept at managing a wide variety of patient populations and pathology.

PROVIDING DIVERSE AND IN-DEPTH TRAINING Ivonne Schulman, MD, was appointed program director and oversees the training of ten nephrology fellows.

David Roth, MD, who chairs the Clinical Competency Committee, assures that the Accreditation Council for Graduate Medical Education Next Accreditation System’s milestones are met. In addition to offering diverse and in-depth training for the general nephrology fellows, additional one-year fellowships are available in Interventional Nephrology with Loay Salman, MD, and in Transplant Nephrology, overseen by Giselle Guerra, MD. This one-year program makes the University of Miami’s one of the most unique in the nation.

CRITICAL CARE FELLOWSHIP The Critical Care Medicine fellowship offers training in the specialty of Critical Care for graduates of Internal Medicine residencies. This training includes rotations in specialty medical, surgical, trauma, neuroscience, and bone marrow transplant units. Also included are related fields such as anesthesiology, echocardiography and nutrition support.

WORKING TO IMPACT PATIENTS ACROSS THE REGION The Division of Infectious Diseases is committed to the development of the next generation of infectious disease specialists. The ID Fellowship program is spearheaded by Susanne Doblecki-Lewis, MD, and Paola Lichtenberger, MD, and its mission is to improve the diagnosis, treatment, and prevention of infectious diseases.

Graduates go on to occupy many leadership positions in the clinical, academic and public health arenas throughout the region.

There are five concurrent inpatient infectious diseases services, including a dedicated transplant/ immunocompromised host service. JMH and the UM Hospital have 24/7 specialized ID pharmacists to support and assist with antimicrobial issues.

The pass rate for the Infectious Diseases Boards has been 100% for the last eight years and completion of an D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

FLEXIBLE AND BROAD-SPECTRUM TRAINING The Fellowship Training program in Pulmonary and Critical Care Medicine is a three-year program that makes trainees eligible for certification by the American Board of Internal Medicine in Pulmonary Diseases and Critical Care Medicine. The overall objective of the program is to prepare trainees for a wide spectrum of career opportunities with an overreaching goal to produce the next generation of leaders in Pulmonary and Critical Care Medicine. The program encompasses more than 1,800 beds and a large outpatient population, and is unique in several aspects. The flexibility allows the trainees to obtain in-depth training in clinical aspects of cystic fibrosis, interstitial lung disease, pulmonary hypertension, and obstructive lung diseases, as well as experience and research in the field.

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Residents & Fellows NAME

MEDICAL SCHOOL

GENERAL INTERNAL MEDICINE PGY-1 Al Sharhan, Loulwa Ashukem, Moses Badlani, Jayshiv Brice, Aaron Chapman, Ryan Diaz, Carlos Duncan, Arielle Henderson, Armen Hjelm, Nikolaus Kirolos, Irene Laderian, Bahar Mason, Ajani Morel, Charlotte Mosetti, Maria Antionetta Muenyi, Valery Nguyen, Nhi Puig, Enrique Saravia, Diana Schwartz, Marc Thekkumkattil, Anu Tookes, Hansel Vitolo, Melissa Watford, Daniel Wu, Grace

Kuwait University Virginia Commonwealth University School of Medicine University of Pittsburgh School of Medicine University of Virginia School of Medicine Nova Southeastern University College of Osteopathic Medicine Rush Medical College of Rush University School of Medicine Virginia Commonwealth University School of Medicine Meharry Medical College Jefferson Medical College of Thomas Jefferson University Misr University for Science and Technology University of Pittsburgh School of Medicine Howard University College of Medicine New York Medical College Universita degli Studi di Roma ’La Sapienza’ Facolta di Medicina e Psicologia Meharry Medical College Washington University in St. Louis School of Medicine Ponce School of Medicine University of Miami Leonard M. Miller School of Medicine The School of Medicine at Stony Brook University Medical Center University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Jefferson Medical College of Thomas Jefferson University University of North Carolina at Chapel Hill School of Medicine University of Illinois at Chicago College of Medicine

PGY-2 Alansari, Yahya Armstrong, Antonio Augustin, Dimitri Bahadu, Shaka Berbel Caban, Ana Calzadilla, Andrew DeMaria, Peter Elden, Andrew Fernandez, Rafle Fernandez de la Vara, Aymara Garcia, Alexander Gilinsky, Dani Joshi, Shivam Justmann, Courtney Karsner, Ryan Kataria, Rahul Khalid, Laiqua Lisigurski Teitelman, Miriam Olshan, Marc Ramdial, Jeremy Sparrow, Quinton Suncion, Viky Vilches, Elizabeth Vu, Ann Ying, David

Arabian Gulf University Ponce School of Medicine University of Miami Leonard M. Miller School of Medicine Weill Cornell Medical College Ponce School of Medicine Florida State University College of Medicine University of Miami Leonard M. Miller School of Medicine UMDNJ-New Jersey Medical School University of Miami Leonard M. Miller School of Medicine Temple University School of Medicine Nova Southeastern University College of Osteopathic Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine George Washington University School of Medicine and Health Sciences Temple University School of Medicine Aga Khan Medical College Universidad Peruana Cayetano Heredia Drexel University College of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Universidad Nacional Mayor de San Marcos Facultad de Medicina San Fernando Universidad Central del Caribe School of Medicine University of Miami Leonard M. Miller School of Medicine Washington University of St. Louis School of Medicine

PGY-3 Alsulaimi, Ali Berera, Shivali Buryk,Yaroslav Campos, Maira Dholaria, Kevin Fernandez, Karen Fonts, Ernesto Goldenberg, Vanessa Grant, Quintesia Hanoush, Zeina Jennings, Marcus Joseph, Tameka Kaknes, Nicholas Kusnir, Juan LaConti, Joseph

Kuwait University University of Miami Leonard M. Miller School of Medicine Bukovynian State Medical Academy Fundacao Universitaria do Abc Virginia Commonwealth University School of Medicine State University of New York Downstate Medical Center Georgetown University School of Medicine University of Colorado School of Medicine Virginia Commonwealth University School of Medicine Universidad Central de Venezuela-Luis Razetti University of Tennessee Health Science Center University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Temple University School of Medicine Georgetown University School of Medicine

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U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

NAME

MEDICAL SCHOOL

Lucero, Thomas Macon, Conrad Mendez, Vanessa Pagan, Javier Pierre, Rachel Ramireddy, Archana Rodriguez, Alexis Salzberg, Matthew Sendzischew, Morgan Sfeir, Maroun Spain, Adam

University of Colorado School of Medicine University of Miami Leonard M. Miller School of Medicine Universidad Central del Caribe School of Medicine Ponce School of Medicine Nova Southeastern University College of Osteopathic Medicine Virginia Commonwealth University School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Lebanese University Duke University School of Medicine

WILLIAM J. HARRINGTON LATIN AMERICAN TRAINING PROGRAM PGY-1 Chavez Morales, Efren Alejandro de la Cruz Luque, Celso Fernando Duque Ballesteros, Juan Camilo Dvorquez, Denise Kimble, Erik Lesley Lorio, Marco Malpica Castillo, Luis Enrique Mendirichaga, Rodrigo Monge Urrea, Jorge Nunez Breton, Jonatan David Pardinas Gutierrez, Miguel Agustin Pena Polanco, Nathalie Aurora

Universidad Autonoma de Chihuahua, Mexico Universidad Peruana Cayetano Heredia, Peru Universidad de la Sabana, Colombia Universidad Catolica de Santiago de Guayaquil, Ecuador Universidad de Guadalajara, Mexico Universidad Nacional Autonoma de Nicaragua, Managua Universidad Peruana Cayetano Heredia, Peru Universidad de Moterrey, Mexico Universidad Anahuac, Mexico Pontificia Universidad Catolica Madre y Maestra (PUCMM),DR Westhill Institute, Mexico Pontificia Universidad Catolica Madre y Maestra (PUCMM),DR

Preliminary Year Alvarez, Edilberto Dienes, Spencer Ezuddin, Mohammed Herskovitz, Ingrid Heywood, Kendrick Hosein, Khadil Howard-Jones, Jametria Parvus-Teichmann, Chad Phillips, Mitchell Richmond, Nicholas Riotti, Jessica Romannikov, Vladimir Shah, Kush Shaurya, Kautilya

Florida International University Herbert Wertheim College of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine Fundacao Universitaria do ABC University of Florida College of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine University of Miami Leonard M. Miller School of Medicine

PGY-2 Arciniegas, Rafael Bueno Rios, Maria X. Corral, Juan E. Diaz, Liege I. Dookhan, Christina M. Gallastegui Crestani, Nicolas Gomez Arteaga, Alexandra Hernandez, Rafael E. Nascimento Cardoso, Rhanderson M. Novoa, Italo C. Perez, Sergio A. Torres, Alfredo E.

Universidad Central de Venezuela – Jose MariaVargas, Venezuela Universidad San Martin de Porres, Peru Universidad Francisco Marroquin, Guatemala Universidad de Panama, Panama University of the West Indies, Trinidad Universidad San Martin de Porres, Peru Universidad de los Andes, Santa Fe de Bogota, Colombia Universidad Iberoamericana, Santo Domingo, Dominican Republic Faculdade de Medicina da Universidade Federal de Goias, Brazil Universidad Peruana Cayetano Heredia, Peru Universidad del Valle, Cali, Colombia Universidad de Carabobo, Valencia, Venezuela

PGY-3 Castellanos, Raquel Dejman, Adriana Donet Mostacero, Jean Gallegos, Cesia Garcia, Daniel C. Gomez, Camilo Jurado, Marilu Palacio Cardenas, Sofia Pinto Miranda, Veronica Rico Tresgallo, Rene Risquez, Cristobal Trivella, Juan

Universidad de El Salvador Universidad Central de Venezuela-Jose Maria Vargas Universidad Nacional de Trujillo Universidad Nacional Autonoma de Honduras Faculdade de Medicina da Universidade Federal de Goias Universidad de la Sabana Universidad Catolica de Santiago de Guayaquil Instituto de Ciencias de la Salud (Ces) Universidad Nacional Mayor de San Marcos Universidad Anahuac Universidad Central de Venezuela-Jose Maria Vargas Universidad Central de Venezuela-Luis Razetti

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

15

Residents & Fellows NAME

CURRENT POSITION

MEDICAL SCHOOL

CARDIOVASCULAR Badiye, Amit PGY5 Braghiroli, Joao PGY4 Damluji, Abdulla PGY6 Desai, Harit V PGY7 Dyal, Michael PGY6 Elias, Elliott PGY4 Fox, Arieh PGY5 Ghatak, Abhijit PGY7 Goyal, Vishal PGY5 Hawk, Christopher PGY4

Healy, Chris PGY6 Hernandez, Gabriel PGY4 Karnabi, Eddy PGY5 Khazai, Bahram PGY5 Kolappa, Kamalkumar PGY6 Macatangay, Constancia PGY5 Marzouka, George PGY6 Mushtaq, Muzammil PGY4 Nasehi Oskouei, Behzad PGY6 Otalvaro Orozco, Lynda PGY6 Patel, Nish PGY4 Rengifo-Moreno, Pablo A PGY7 Singh, Vikas PGY5 Smairat, Ramez PGY4

Internal Medicine, Orlando Health, Orlando, FL University of Miami- Jackson Memorial Hospital, Miami, FL Pennsylvania State University & College Of Medicine, Hershey, PA Westchester Medical Center/New York Medical College, Valhalla, NY Jackson Memorial Hospital, Miami, FL Icahn School of Medicine at Mount Sinai, New York, NY New York- Presbyterian/ Columbia University Medical Center, New York, NY University of Connecticut, Farmington, CT Allegheny General Hospital-Western Pennsylvania Hospital, Pittsburgh, PA Columbia University Medical Center- New York Presbyterian Hospital, New York, NY University of Illinois at Chicago, Chicago, IL University of Miami-Jackson Memorial Hospital, Miami, FL Hospital of St. Raphael/ Yale New Haven Hospital, New Haven, CT Loma Linda University, Loma Linda, CA University of North Carolina, Chapel Hill, NC University of Connecticut Health Center-Hartford Hospital, Hartford, CT University of Miami- Jackson Memorial Hospital, Miami, FL Mount Sinai School of Medicine, New York, NY Franklin Square Hospital Center, Baltimore, MD University of Miami-Jackson Memorial Hospital, Miami, FL University of Oklahoma Health Sciences Center, Oklahoma City, OK St. Elizabeth’s Medical Center, Boston, MA University of Miami-Jackson Memorial Hospital, Miami, FL University of Miami-Jackson Memorial Hospital, Miami, FL

ENDOCRINOLOGY, DIABETES, AND METABOLISM Acevedo Morales, Daisy PGY 5 Castillo, Melany PGY 5 Muigai, Ngina (Chief Fellow) PGY 6 Rojas, Andreina PGY 5 Gra Menendez, Silvia PGY 4 Mohseni, Mahshid PGY 4 Perez Bustamante, Marcela PGY 4

Rosen Berger, Hara PGY 4

Jackson Memorial Hospital/University of Miami-Internal Medicine Jackson Memorial Hospital/University of Miami-Internal Medicine Baystate Medical Center-Internal Medicine St. Vincent’s Medical Center-Internal Medicine Cleveland Clinic Florida-Internal Medicine Marshall University School of Medicine-Internal Medicine University of Miami Miller School of Medicine Palm Beach Regional Campus-Internal Medicine Mount Sinai Medical Center-Internal Medicine

Artist House Anemone in Komodo, Indonesia

by Marc Lippman, MD, MACP, FRCP, Leonard M. Miller Professor of Internal Medicine, Psychiatry and Behavioral Sciences and Deputy Director,

GASTROENTEROLOGY Arosemena, Leopoldo Barkin, Jodie Calmet, Fernando Carrion, Andres Czul, Frank Gosalia, Ashil Green, Patrick Huang, Michael Kalra, Gorav Kingsley, Michael Perlini, Erin Rabiee, Atoosa Reddy, Naveen Sclair, Seth Szeto, Winnie

in the

Sylvester Comprehensive Cancer

PGY6 PGY4 PGY4 PGY6 PGY5 PGY4 PGY6 PGY6 PGY4 PGY5 PGY4 PGY5 PGY6 PGY5 PGY5

Jackson Memorial Hospital Jackson Memorial Hospital Jackson Memorial Hospital Jackson Memorial Hospital Jackson Memorial Hospital Brown University/Rhode Island Jackson Memorial Hospital Boston University Medical Center St. Louis University School of Medicine Mount Sinai School of Medicine/Miami Jackson Memorial Hospital Johns Hopkins University School of Medicine Boston University Medical Center Jackson Memorial Hospital University of Maryland

Fellow

Jackson Memorial Hospital

Center, University of Miami Miller School of Medicine

GENERAL INTERNAL MEDICINE Chang, Aileen

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U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

NAME

CURRENT POSITION

LOCATION OF RESIDENCY

GERIATRICS AND PALLIATIVE MEDICINE Cabeza Rivera, Franco Fernandez, Itzel Garcia, Maraida Hartmann, Nicholas Khawand-Azoulai, Mariana Mangudo, Jean Paul Cerceaux McMullen, Beatriz Medina, Suleyki Nandra, Jasyendar Singh Tehrani, Marjan Walwyn, Emron

PGY5 PGY5 PGY4 PGY5 PGY4 PGY4 PGY4 PGY4 PGY4 PGY4 PGY4

Jackson Memorial Hospital New York Medical College San Juan City Hospital University of Miami/Cleveland Clinic Columbia/New York Presbyterian St. Louis University School of Medicine Bella Vista Hospital Lutheran Medical Center UPMC-McKeesport Hospital-University of Pittsburg Medical Center St. Louis University School of Medicine Ochsner Medical Center

PGY4 PGY5 PGY6 PGY5 PGY4 PGY6 PGY4 PGY6 PGY6 PGY5 PGY6 PGY5 PGY4 PGY5 PGY4 PGY5

Metropolitan Hospital Center, NYMC Staten Island University Hospital, NY Jackson Memorial Hospital State University of New York at Buffalo (SUNY Buffalo) Memorial Hospital of Rhode Island Jackson Memorial Hospital Weiss Memorial Hospital, Chicago, IL Jackson Memorial Hospital Jackson Memorial Hospital Nassau University Medical Center, Long island Henry Ford Hospital, Michigan Rosalind Franklin University of Medicine and Sciences North Chicago, IL Jackson Memorial Hospital Harbor Hospital Medical Center Baltimore, MD Albert Einstein Medical Center, Philadelphia Jackson Memorial Hospital

PGY7 PGY7

Jackson Memorial Hospital Medical College of Wisconsin Affiliated Hospitals, Inc

PGY5 PGY5 PGY4 PGY4 PGY5 PGY4 PGY4 PGY4 PGY4 PGY5

Cooper University Hospital, Camden, NJ Lincoln Medical and Health Center, Bronx, NY Maimonides Medical Center, Brooklyn, NY Morristown Medical Center, Morristown, NJ University of Texas School of Medicine, Houston, TX Cleveland Clinic Florida, Weston, FL Jackson Memorial Hospital, Miami, FL Lahey Hospital and Medical Center, Burlington, MA Jackson Memorial Hospital, Miami, FL Mount Sinai Medical Center, Miami Beach, FL

HEMATOLOGY-ONCOLOGY Alderuccio, Juan Azzi, Georges Dammrich, Daniel Dawar, Richa Desai, Amrita Deutsch, Yehuda El Dinali, Mohamed Escobar Mauricio Fabregas, Jesus Hurtado-Cordovi, Jorge Khushman, Moh’d Parajuli, Ritesh Sandoval, Ana Tinoco, Gabriel Vargas, Fernando Warsch, Sean

HEPATOLOGY Manten, Emory Martin, Eric

INFECTIOUS DISEASES Doktor, Katherine Gomez, Isabel Groner, Mordechai Hurtado Gomez, Gabriel Iwunze, Rosemary Lakshmi, Seetha Rosa, Rossana Shaikhomer, Mohammed Shimose, Luis Toirac-Perdomo, Janet

NEPHROLOGY AND HYPERTENSION Abdullah, Shurkri Acevedo, Bernice El Kassem, Mohamed Keshav, Roger Zeyala, Sheyla Abu Garara, Hazem Sabucedo, Alberto Cardona-Guzman, Jose Miguel Valdes, Alejandro Garcia, Rene A.

PGY 5 PGY 5 PGY 5 PGY 5 PGY 5 PGY 4 PGY 4 PGY 4 PGY 4 PGY 4

Michigan State University, McLaren Hospital Jackson Memorial Hospital/University of Miami-Internal Medicine Upstate Medical University-Wilson Memorial Medical (SUNY) UMDNJ-New Jersey Medical School-Internal Medicine Jackson Memorial Hospital/University of Miami-Internal Medicine Texas Tech University-Internal Medicine University of South Florida-USF Health-Internal Medicine Orlando Regional Medical Center-Internal Medicine The Jewish Hospital of Cincinnati-Internal Medicine The Jewish Hospital of Cincinnati-Internal Medicine

RHEUMATOLOGY AND IMMUNOLOGY Dehrab, Ahmad Haffizulla, Kristin Singh, Shelley Zanotti, Magali

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

Fellow Fellow PGY4 PGY4

Jackson Memorial Hospital Jackson Memorial Hospital Mount Sinai Medical Center/Miami Cooper Hospital-University Medical Center

17

Residents & Fellows NAME

CURRENT POSITION

MEDICAL SCHOOL

JOHN F KENNEDY HOSPITAL IN WEST PALM BEACH RESIDENTS Bethel-Ellison, Samantha Bhushan, Kacie Embry, Faneece Furlan, Stefanie Garnet, Brian George, Griffen Giscombe, Lisa-Gaye Haque, Nyrene Khalil, Maya Koka, Sagarika Kreidieh, Omar Kushnir, Alexander Lee Ching, Cathy Mercado, Julio Mulee, Jacqueline Pazin, Benjamin Pino Moreno, Jesus Sarkis, Fayez Sautter, Robert Savas, Jessica Shah, Varun Tenzel, Phillip Valle Goffin, Janeiro Vega Blanco, Roger Wang, Danlu Ward, William Al Yaseen, Saif Aldana Campos, Martin Alrifai, Abdulah Aubel, Troy Avalos, Danny Bunton, Cristina El Dassouki, Saleh Gleitmann, Lisa Hayes, Edwin Kabach, Mohamad Kostioukhina, Ekaterina Marian, Diana Morales, Fabio Negron, Rebecca Pathak, Vishesh Porter, Jessica Rives-Sanchez, Marisela Solanki, Ekta Tambini, Pamela Torres, Yolaine Valluri, Sri Kartik Vijayvargiya, Prakhar Ajibade, Adetola Akinnifesi, Oluwadamilola Bredemus, Alysha Bueno Acedo, Isabel Charles, Cornelia Daniel, Stephen Dayanand, Sandeep El Khatib, Ahmad Lopez, Marvin Manickam, Sampath Martinez, Jasmin Miller, Mistyann-Blue Mora Garzon, Magda Osorno Ramirez, Hernan Razzouk, Elie Regis, Catarina Rodriguez, Eduardo Samra, Wassim Schiffman, Amy Sharma, Vishala Yarsley, Jason 18

PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG1 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG2 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3 PRG3

Howard University College of Medicine, Washington, DC Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL Medical College of Georgia, Augusta, GA Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL University of Miami Miller School of Medicine, Miami, FL University of Queensland School of Medicine, Herston Ross University School of Medicine, Roseau University of Kentucky College of Medicine, Lexington, KY American University of Beirut Faculty of Medicine, Beirut Royal College of Surgeons in Ireland School of Medicine, Dublin American University of Beirut Faculty of Medicine, Beirut Florida State University College of Medicine, Tallahassee, FL Universidad Católica de Santiago de Guayaquil Facultad de Ciencias Médicas, Guayaquil Ross University School of Medicine, Roseau American University of the Caribbean School of Medicine, Cupecoy Ross University School of Medicine, Roseau Fundación Universitaria San Martín Facultad de Medicina, Bogota American University of Beirut Faculty of Medicine, Beirut Ross University School of Medicine, Roseau University of Miami Miller School of Medicine, Miami, FL Rajarshi Chhatrapati Shahu Maharaj Government Medical College Kolhapur, Kolhapur University of Miami Miller School of Medicine, Miami, FL Universidad Americana (UAM) Facultad de Medicina, Managua Universidad Nacional Autónoma de Nicaragua Facultad de Ciencias Médicas, Managua, Managua Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL University of Miami Miller School of Medicine, Miami, FL Al-Kindi College of Medicine, University of Baghdad Universidad Industrial de Santander University of Damascus University of Miami Miller School of Medicine, Miami, FL Ross University School Howard University College of Medicine, Washington, DC Kauno Medicinos Universitetas American University of the Caribbean University of Miami Miller School of Medicine, Miami, FL University of Damascus University of Miami Miller School of Medicine, Miami, FL Fundacion Universitaria San Martin Ross University School Ross University School Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL Ross University School San Juan Bautista Escuela de Mediciina, Caguas, PR Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL Ross University School Universidad Iberoamericana Bhaskar Medical College, Yenkapally Grant Medical College, Mumbai Howard University College of Medicine, Washington, DC Wake Forest University School of Medicine, Winston-Salem, NC Ross University School Universidad Central De Venezuela Luis Razeiti School of Medicine Howard University College of Medicine, Washington, DC Medical University of South Carolina, Charleston, SC Sri Venkatesvara Medical College University of Balamand Universidad Americana University of Miami Miller School of Medicine, Miami, FL Central University of Venezuela Morehouse School of Medicine, Atlanta, GA University of Caldas Universidad CES American University of Beirut Universidade Federal Da Bahia San Martin De Porres University University of Damascus University of Miami Miller School of Medicine, Miami, FL Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL Nova Southeastern University College of Osteopathic Medicine, Fort Lauderdale, FL U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

RESIDENT NAME

MEDICAL SCHOOL

MEDICINE-PEDIATRICS PGY-1 Flowers, Chad Petrauskis, Christian Saxena, Anjali Schneider, Jessica Thorngren, Daniel

PGY-2 Gonzalez, Sam Meza, Ben Park, Jane Parris, Brent Van Kirk, Kendra

PGY-3 Afanador, Andres Afanador, Hayley Allport, Brandon Cueto, Victor Heuring, LoAnn

PGY-4 Adeyeri, Kemi Cooper, Nicole Imm, Matthew Redwood, Abiona Wong, Lena

Indiana University School of Medicine Georgetown University School of Medicine University of Arkansas College of Medicine University of Colorado School of Medicine University of Chicago - The Pritzker School of Medicine

The University of Miami Leonard M. Miller School of Medicine was founded in 1952 as the first medical school in Florida and is acclaimed nationally and internationally for research, patient care, education and

Ponce School of Medicine University of Pittsburgh School of Medicine University of Colorado School of Medicine Stony Brook University School of Medicine Howard University College of Medicine The Brody School of Medicine at East Carolina University The Brody School of Medicine at East Carolina University Baylor College of Medicine Drexel University College of Medicine Rutgers- New Jersey Medical School

community service in the United States, South America and the Caribbean.

Serving more than five million people as the only academic medical center in South Florida, the Miller School of Medicine has earned international acclaim for its patient care and research innovations.

Duke University School of Medicine Baylor College of Medicine Ohio State University College of Medicine Duke University School of Medicine Temple University School of Medicine

The Miller School of Medicine campus consists of 35 acres within the 80-acre complex of the Miami Health District, including more than 2 million square feet of research space, and ranks in the top third among U.S. medical schools in terms of research funding awarded.

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Cardiovascular Division Treating Patients throughout South Florida The Cardiovascular Division at the Miller School of Medicine continues to be at the forefront of clinical cardiac care, offering a wide spectrum of diagnostic testing and therapeutic interventions. With more than 10,000 outpatient visits annually across multiple locations (Miami, Boca Raton, Plantation, Kendall), the Division serves a wide variety of cardiac disorders including coronary artery disease and valve abnormalities and has created a lasting imprint across South Florida.

The Cardiovascular Division is comprised of 32 faculty members engaged in key disciplines including electrophysiology, cardiac imaging, interventional cardiology, cardiac rehabilitation and heart failure.

HEART FAILURE MONITORING The Cardiovascular Division is proud to be the first in South Florida to offer CardioMEMs, a new innovative device for the management of heart failure. Sandra Chaparro, MD, Assistant Professor of Medicine and Director of the Heart Failure Clinic, is pioneering the use of this miniature sensor, which allows for the lifetime monitoring of pulmonary artery pressure in heart failure patients. This allows a physician to detect an individual’s condition and adjust treatment. It also provides patients the peace of mind that their condition is being closely monitored.

There are over 670,000 new cases of heart failure diagnosed each year in the United States, and these patients often require hospitalization. Costing the U.S. $31 billion in 2012, these patients often suffer a reduced quality of life and increased mortality.

The CardioMEMs system is the first FDA approved device for the continuous internal monitoring of heart failure. This device may help UM cardiologists optimize the treatment of heart failure, reducing the need for hospitalizations, improving the quality of patients’ lives and decreasing healthcare costs.

CARDIAC ARRHYTHMIA ABLATION Electrophysiology has undergone great advances in the treatment of electrical disturbances of the heart under the direction of Raul Mitrani, MD, Associate Professor of Medicine and Director of Clinical Cardiac Electrophysiology. Dr. Mitrani and James O. Coffey, MD, Assistant Professor of Medicine, are the first physicians in South Florida to use a contact-force catheter called the Smart Touch ablation catheter. Cardiac ablation treatments modify regions of heart muscle that cause abnormally fast heart rhythms. These heart disorders can put patients at risk of stroke and sudden cardiac death.

This new catheter is adding greater safety and efficacy to the complex ablation procedures the electrophysiology team performs.

Stem Cell Center photo & long caption

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EDUCATING THE CARDIOVASCULAR SPECIALISTS OF THE FUTURE Internal medicine residents attend multiple conferences held by the cardiovascular faculty, and specific rotations in cardiology are available both at UMH and JMH. More than ten internal medicine residents have presented this past year at national cardiology meetings.

In addition, there are 21 general cardiology fellows who come from the top training programs in the U.S. and throughout the world. Subspecialty fellowships are also available for heart failure, electrophysiology, and interventional cardiology.

USING NEW TECHNOLOGY FOR HEART RHYTHM DISTURBANCES Advanced ablation therapy for atrial and ventricular arrhythmias is one of the key programs of the Division.

Juan Viles-Gonzalez, MD, James Coffey, MD, and Raul Mitrani, MD, were among the first clinicians to use the SmartTouch ablations catheter, an advanced pressuresensitive catheter to treat patients with potentially dangerous heart rhythm disorders. This group also pioneered the application of the RevealLINQ implantable device which is very small and may be used to monitor heart rhythm over a long period of time.

AORTIC STENOSIS A team-based approach, spearheaded by Mauricio Cohen, MD, and Alan Heldman, MD, has revolutionized the treatment of aortic stenosis, using aortic valvuloplasty and transcatheter aortic valve replacement (TAVR). With a state-of-the-art hybrid cath lab, the Valve Team was the first group in South Florida to start TAVRs and has now performed more than 500 TAVRs using transfemoral, transapical, and transoartic approaches. The interventional group participated in the pivotal clinical trials for both the Edwards Sapien balloon-expandable valve and the CoreValve self-expanding valve. Very soon, the group will begin clinical trials to assess second generation repositionable transcatheter aortic valves including the Lotus valve and the Direct Flow valve.

DIVISION FACULTY LIST Robert C. Hendel, MD Interim Division Chief Director, Cardiac Imaging and Outpatient Services, Director, Cardiac Care Unit and Cardiology Service Chief, University of Miami Hospital Professor of Medicine and Radiology Professors of Medicine Nanette H. Bishopric, MD Director, UM/Florida Heart Research Institute Cardiovascular Genomics Laboratory Simon C. Chakko, MD Chief, Cardiology Miami Veterans Affairs Medical Center Eduardo J. De Marchena, MD Associate Dean of International Medicine Pascal J. Goldschmidt, MD Senior Vice President of Medical Affairs and Dean Joshua M. Hare, MD Director, Interdisciplinary Stem Cell Institute Alan W. Heldman, MD Director of Interventional Cardiology / Medical Director, Heart Valve Program Robert J. Myerburg, MD Alberto Interian, MD Rafael F. Sequeira, MD Professors of Clinical Medicine Maureen H. Lowery, MD Clerkship Director of Internal Medicine at UMMSM Donald G. Rosenberg, MD Medical Director, Miami-Dade Fire Rescue Associate Professors of Medicine Martin S. Bilsker, MD Director, Echocardiography Laboratory, University of Miami Hospital; Outpatient Cardiology Clinic, Jackson Memorial Hospital Mauricio G. Cohen, MD Director, Cardiac Catheterization Laboratory Chunming Dong, MD Raul Mitrani, MD

Associate Professors of Clinical Medicine Kathy Hebert, MD Director Disease Management and Outcomes Research Claudia A. MartinezBermudez, MD Carl E. Orringer, MD Eugene J. Sayfie, MD Medical Director, Executive Health Alan H. Schob, MD Medical Chief, Catheterization Laboratory, Miami Veterans Affairs Medical Center David M. Seo, MD Chief Medical Information Officer Howard J. Willens, MD Assistant Professors of Medicine James O. Coffey, MD Juan Viles-Gonzalez, MD Lina Shehadeh, PhD Assistant Professors of Clinical Medicine Carlos E. Alfonso, MD Cardiology Fellowship Program Director Sharon N. Andrade-Bucknor, MD Medical Director, Cardiac Rehabilitation Program Antonio Barquet-Leon, MD Eugene J. Bauerlein, MD Sandra Chaparro, MD Director of Heart Failure Clinic / Director of Heart Failure/Transplant Fellowship Program Roberto A. Miki, MD Robert B. Stang, MD Research Assistant Professor Jianqin Wei

HEART FAILURE Heart failure treatment continues to be an important focus of the Division. Working in collaboration with the Miami Transplant Institution at Jackson Memorial Hospital, Sandra Chaparro, MD, and E. Joseph Bauerlein, MD, work with current and future heart transplant patients, as well as offer a variety of advanced treatments.

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Division of Clinical Pharmacology Dedicated to Researching the Effects of Pharmaceutical Agents in Humans The Division of Clinical Pharmacology is primarily a research Division dedicated to the investigation of the effects of new pharmacological agents and disease mechanisms in humans. Having a long and established record of successful research across a wide range of therapeutic areas, the Division of Clinical Pharmacology is located within the Clinical Pharmacology Research Unit at the Miller School of Medicine campus. The Clinical Pharmacology Research Unit specializes in Phase I Special Populations research which is the early study of drug action and drug handling by the body in humans with kidney and liver diseases.

THE DIVISION’S FOUR CORE MISSIONS • • • •

Conducting original research to investigate how drugs react in the human body.

Designing and conducting special populations Phase I research studies.

Supporting the Miller School of Medicine research infrastructure.

Conducting Phase I Special Populations studies across a wide range of therapeutic areas.

The University of Miami Medical School complex has three large teaching hospitals, as well as associated specialty clinics. As one of the largest medical centers in the United States, the Clinical Pharmacology Research Unit draws from a huge patient population base and a large number of specialty clinics. The Division interacts closely with clinical investigators and supports a wide array of research.

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THE CONNECTION BETWEEN MENOPAUSE AND HYPERTENSION This past year, the Division published the results of a study conducted at the Clinical Pharmacology research Unit in Hypertension, the leading medical journal in the field. Researchers examined the role of nitric oxide, which promotes vascular health, in post-menopausal hypertensive Hispanic women, a population known to have a high prevalence of sodium sensitivity. A person who is sodium sensitive experiences an elevation in blood pressure when they increase their intake of sodium.

Sodium sensitivity is important because it is a precursor of elevated blood pressure, and may itself create an increased risk for organ damage.

It is widely recognized that menopause is often accompanied by an increase in both sodium sensitivity and hypertension, which may partially explain the corresponding increased cardiovascular risk observed in post-menopausal women. The role of nitric oxide was studied in 19 postmenopausal hypertensive Hispanic women.

The results of the study indicate that sodium sensitivity is complex and provided further insight towards understanding these mechanisms, which will be key for the development of improved pharmacological treatments.

Queen angelfish (Holacanthus ciliaris) at the Florida Keys National Marine Sanctuary in Key Largo, Florida by Robert M. Jackson, MD, FACP, Associate Chief of Staff for Research Miami VAHS, Professor of Medicine, Pulmonary & Critical Care, University of Miami Miller School of Medicine.

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DIVISION FACULTY LIST Richard A. Preston, MD, MSPH, MBA Division Chief Professor of Clinical Medicine

Professor of Medicine Barry J. Materson, MD, MBA

INVESTIGATING HOW POTASSIUM IS PROCESSED BY THE KIDNEYS This past year, the Division continued working towards understanding how the kidneys regulate the amount of potassium in the body. The kidneys are responsible for maintaining potassium levels so that cells are able to function properly, such as those that ensure the heart beats normally, and that muscles function properly.

Current studies are aimed at demonstrating a newly discovered pathway by which the gastrointestinal tract communicates with the kidneys to regulate the amount of potassium that they eliminate. The results of this important study should be available in 2015.

DRUG RESEARCH PROVES VITAL FOR KIDNEY AND LIVER DISEASE PATIENTS Pharmacokinetics is the study of how the body processes a medication. Specifically researched is how absorption occurs from the stomach and gastrointestinal tract, how a medication is distributed within the body, and how the kidneys and liver eventually eliminate a medication from the body. Studying pharmacokinetics and ensuring the safety of new medications is a central mission of the Clinical Pharmacology Research Unit, which has an international reputation for conducting complex research in patients with kidney and liver disease.

Research Associate Professor David Afshartous, MD

Most recently, a study was conducted on the effects of a new antihypertensive medication that included 24 study participants with kidney disease and 24 corresponding healthy volunteers. The results of the research suggest that the new medication is safe in patients with kidney disease and requires no dose adjustment. This is yet another example of how testing new medications in patients with kidney and liver disease is a key step in the drug development and approval process.

IMPORTANT STUDY ON SODIUM BALANCE ANSWERS 30-YEAR OLD RESEARCH QUESTION About 30 years ago, doctors determined that a signaling mechanism must exist whereby the stomach and gastrointestinal tract tell the kidneys to begin producing sodium. The Inpatient Clinical Pharmacology Research Unit systematically investigated the existence of this system and discovered new hormones present in 15 healthy volunteers who were on both high and low sodium diets. Although the results of the study did not prove that a signaling mechanism exists, the research developed international interest and was published in a highly-rated medical journal because it helped to answer an important and age-old question about how the body handles sodium.

A long and established record of successful research

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Division of Endocrinology, Diabetes, and Metabolism The Second Largest Outpatient Practice within the Department The Division hosts the second largest outpatient practice within the Department of Medicine, generating 12% of total outpatient visits and handling approximately 16,000 patients in Fiscal Year 2014. In order to better accommodate patient needs, the Division opened two “Fast Track” teaching clinics located at the Diabetes Research Institute (DRI) and the Sylvester Cancer Center.

As the incidence of endocrine disorders such as obesity, diabetes and thyroid cancer continue to rapidly increase, our Division has been able to match this significant growth with its diverse expertise and expansion to satellite clinics. Practice locations currently include the UM main campus, Kendall, Miami Lakes and Deerfield.

Additionally, endocrinologists provide inpatient care at the University of Miami Hospital, the Sylvester Cancer Center, Jackson Memorial Hospital and the VA Hospital.

The one-of-a-kind Dynamic Endocrine Testing center is based at the DRI and provides accurate and dependable endocrine function testing. Standardization of all procedures and protocols is essential for the reliable interpretation of endocrine testing results.

Pituitary and Neuroendocrine experts are active collaborators and leaders of national and international medical societies that specialize in providing care to patients with pituitary tumors and other diseases.

The Division’s commitment to excellence can been seen in the faculty members who have recently been recruited to join the team. Diala El-Maouche, MD, is actively involved in expanding the clinical scope and research portfolio of the bone disorders program in collaboration with Violet Lagari, DO. Distinguished educator, researcher and clinician, Roy E. Weiss, MD, PhD, is internationally recognized for his studies on thyroid disease as well as for his clinical skills and academic leadership. Dr. Weiss joined the Division as departmental Chairman, whereas Dr. Lagari is a recipient of the Young Investigator Award from the American Society for Bone and Mineral Research, and Dr. El-Maouche was honored with the 2013 Endocrine Society Presidential Poster Award.

ADVANCING OUR UNDERSTANDING OF DIABETES AND AUTOIMMUNITY Type 1 Diabetes TrialNet is an international consortium of clinical research centers aimed at the prevention or delay of Type 1 diabetes (T1D). TrialNet researchers at the University of Miami have made significant advancements towards identifying those who are at risk of developing the disease and have discovered various exciting new therapies.

TrialNet has created a large and effective network to screen relatives of persons with T1D for risk, to conduct trials for prevention, and to lay the foundation for future trials.

VITAMIN D IN VULNERABLE ADULTS AT THE VA (VIVA) STUDY Low vitamin D levels are associated with an increased risk for falls. The goal of this study is to determine if high doses of vitamin D will slow down or improve age-related physical decline in a group of elderly and sedentary male veterans. A total of 314 male veterans age 65 to 85 who had poor physical performance and low vitamin D levels participated in this research study.

The results of this investigation could provide evidence to support the use of high doses of vitamin D (4000 IU daily) to improve physical performance.

Andrew V. Schally, PhD., MDhc (Multi), D.Sc,hc Distinguished Leonard M. Miller Professor of Pathology & Professor of Endocrinology, University of Miami Miller School of Medicine Distinguished Medical Research Scientist and Head of The Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center

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DIVISION FACULTY LIST

VITAMIN D IMPROVES PHYSICAL PERFORMANCE IN THE ELDERLY A recent study aimed to determine whether vitamin D intake improved the physical performance and muscle strength of people 65 to 95 years old.

Study participants were given either a low dose (400 IU) or a high dose (2000 IU) of vitamin D3 daily for six months. The results were that those who had the slowest walking speed initially showed improvements in their ability to rise from a seated position. This suggests that vitamin D supplementation can benefit those with low baseline physical functioning.

RESEARCHING DIABETES Division faculty excel in the areas of clinical diabetes, osteoporosis and pituitary disorders and are engaged in leadership positions and academic activities sponsored by trademark societies including the American Diabetes Association, the American Society for Bone and Mineral Research, the American Association of Clinical Endocrinologists and the Endocrine Society.

Additionally, investigators have made seminal contributions towards understanding the biology of the human pancreas.

Studies regarding Type I diabetes have resulted in several high impact publications, while investigators currently research the metabolic effects of new longacting growth hormones.

The Diabetes Research Institute (DRI) is a comprehensive research center dedicated to curing diabetes by helping patients reach insulin independence.

Most recently, scientists have been pioneering techniques to develop a bioengineered “mini organ” that mimics the pancreas and releases the precise amount of insulin needed.

The DRI is a designated Center of Excellence at the University of Miami Miller School of Medicine, providing informative education and training programs for many types of health care professionals and industry representatives. In addition, the DRI’s Kosow Diabetes Treatment Center offers the highest standards of health care delivery, ongoing management and education support, and numerous clinical research possibilities.

Alejandro Ayala, MD Interim Division Chief Associate Clinical Professor of Medicine

Professors of Medicine Rodolfo Alejandro, MD Director of Clinical Islet Transplantation, Director of Metabolic Studies Core & Responsible Head for the Islet Cell Processing Facility at the DRI and Associate Program Director for the General Clinical Research Center at the University of Miami/Veterans Administration Medical Center Hermes Florez, MD Interim Chief, Geriatrics & Palliative Medicine, Director, Division of Epidemiology & Population Health Sciences GRECC Director, Miami VA Healthcare System Ronald Goldberg, MD Associate Director of Medical Affairs of the Diabetes Research Institute & Co-Director of the DRI Clinical Laboratory Professor of Medicine & Associate Professor of Biochemistry and Molecular Biology in the Division of Endocrinology, Diabetes & Metabolism Gianlucca Iacobellis, MD, PhD Director of the University of Miami Hospital Diabetes Service Jennifer Marks, MD Vice Chair for Appointments and Promotion, Section Chief, Endocrinology, Diabetes & Metabolism, & Director, Diabetes Management Program, Miami VAMC Karl Muench, MD Alberto Pugliese, MD Head of the Immunogenetics Program at the DRI Jay Skyler, MD Deputy Director for Clinical Research and Academic Programs at the Diabetes Research Institute Professor of Medicine,Pediatrics and Psychology Jay Sosenko, MD Director of the MD/MPH Program Professor of Medicine, Pediatrics and Epidemiology

Roy Weiss, MD, PhD Chairman of the Department of Medicine Associate Professors Alejandro Ayala, MD Interim Chief of the Division of Endocrinology Assistant Professors of Clinical Medicine Sabina Casula, MD Diala El-Maouche, MD Atil Kargi, MD Fellowship Program Director & Coordinator of the Inpatient Endocrinology Consultation Service Violet Lagari-Libhaber, DO Bresta Miranda-Palma, MD Interim Director of the Kosow DRI Diabetes Treatment Center Maria del Pilar Solano, MD Research Professors of Medicine, Immunology, and Microbiology Luca Inverardi, MD Deputy Director of Translational Research at the Diabetes Research Institute Ricardo Pastori, PhD Director of the Molecular Biology Laboratory at the DRI Research Associate Professors Alejandro Diego CaicedoVierkant, PhD Armando Mendez, PhD Research Assistant Professors Barry Hudson, PhD Lisa Rafkin, MS, RD, CDE Associate Chair for Clinical Coordination

Accommodating growing patient needs

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Division of Gastroenterology Leading the Way with Cutting-Edge Research and Breakthrough Techniques This is an exciting time for the field of Gastroenterology and the Division at the University of Miami.

Gastrointestinal illnesses continue to be the most common reason patients seek medical care. The discovery and characterization of the human microbiome has revealed that intestinal bacteria regulate and control not just gastrointestinal diseases, but many other metabolic diseases, including diabetes.

The Division is committed to the triple mission of leading the research of gastroenterological diseases, offering the best medical care and educating future academic leaders in gastroenterology. The Division offers patients a wide array of disease-specific services centered on improving their health and that of the general population.

Our faculty members have a wide range of special research interests, including esophageal disorders, inflammatory bowel diseases (Crohn’s and ulcerative colitis), gastrointestinal cancer, motility disorders, and pancreatic disorders, as well as advanced diagnostic and therapeutic endoscopy.

A LEADING CENTER FOR CROHN’S DISEASE AND ULCERATIVE COLITIS In April 2013, the Elaine and Sydney Sussman Family Crohn’s & Colitis Clinic at the Sylvester Cancer Center was opened. The Division is performing clinical trials of the most cutting-edge medications used to treat patients with Crohn’s Disease and ulcerative colitis. Perhaps most

impressive is that the Clinic is serving far more patients than initially estimated.

The Clinic is also hoping to understand why Latinos develop inflammatory bowel disease at a rate that seems to outpace the rest of the population. A recently published article revealed that those who have moved from Latin America tend to develop ulcerative colitis, whereas American-born patients of Latin origin tend to develop Crohn’s disease. The Clinic has recently obtained a grant to perform never-before-attempted dietary intervention studies for those with ulcerative colitis, investigating the theory of dietary fat in regulating inflammation and symptoms.

A MOTILITY-SPECIFIC PROGRAM An impressive advancement that has been made is the ability to identify and treat disorders of motility (or movement) of the gastrointestinal tract. The intestine contracts in the process of digestion, pushing food through and absorbing nutrients. In some patients, this process malfunctions, leading to symptoms from constipation to diarrhea. In the past, it was very difficult to measure intestinal motility and characterize defects in this process; however the University of Miami now has a center for motility disorders with state of the art equipment as a part of the Crohn’s and Colitis Center.

Baharak Moshiree, MD, has built the only motility program in South Florida to diagnose issues such as bowel and esophageal disorders. As the number of patients with complicated gastrointestinal disorders continues to rise, the latest diagnostic and treatment GI services are needed.

Dr. Moshiree’s research is focused on the influence of chronic inflammation leading to a decreased pain tolerance in patients with irritable bowel syndrome, as well as whether intestinal Microbiota contributes to a patient’s susceptibility to pain, and whether a genetic predisposition to IBS exists.

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Humpback whales (Megaptera novaeangliae) at the Sanctuary for the Marine Mammals of the Dominican Republic in Silver Bank, Dominican Republic by Robert M. Jackson, MD, FACP, Associate Chief of Staff for Research Miami VAHS, Professor of Medicine, Pulmonary & Critical Care, University of Miami Miller School of Medicine.

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Dr. Moshiree has received grant funding to research new blood tests to identify IBS. This study hopes to identify several markers of inflammation in the colon, as well as other healing parameters being studied in a variety of GI diseases. In collaboration with the Crohn’s and Colitis Center, Dr. Moshiree is trying to determine why some patients with Crohn’s and Colitis continue to have pain even when they no longer have ulcers in their intestine.

BREAKTHROUGH FMT TECHNIQUE Recurrent C. difficile colitis is a leading cause of hospitalacquired illness and places a tremendous burden on the healthcare system. David Kerman, MD, performs Fecal Microbiota Transplantation (FMT), a novel therapeutic technique for the difficult problem of recurrent Clostridium difficile infection. This breakthrough therapy has resulted in the successful resolution of symptoms in over 90% of patients; a success rate rarely attained through common medical therapies. Still an experimental procedure, FMT is allowed by the Food and Drug Administration strictly for this indication. Dr. Kerman is also investigating how to successfully eradicate the original infection in patients that undergo this procedure.

Additionally, FMT provides a window into how the intestinal microbiome relates to common medical problems. The University of Miami is partnering with a team at MIT in Boston to better define the microbial population of the intestine before and after FMT, in order to understand why this infection is so difficult to treat medically, as well as to determine why FMT works so well. Recent scientific literature on the microbiome has provided tremendous insight into Inflammatory Bowel Disease, colon cancer, insulin sensitivity and obesity.

HELPING FAMILIES AND THOSE WITH GENETIC MARKERS FOR COLORECTAL CANCER (CRC)

DIVISION FACULTY LIST Maria T. Abreu, MD Division Chief Professor of Medicine Professor of Microbiology and Immunology Martin Kalser Chair in Gastroenterology

Professors of Medicine Jamie S. Barkin, MD Howard D. Manten, MD Jeffrey B. Raskin, MD Associate Professor of Medicine Baharak Moshiree, MD Associate Professors of Clinical Medicine Amar R. Deshpande, MD Fellowship Program Director Jose A. Garrido, MD Afonso C. Ribeiro, MD

Assistant Professors of Clinical Medicine Oriana M. Damas, MD Paul A. Feldman Roberto Fogel, MD David H. Kerman, MD Marcelo F. Larsen, MD Daniel A. Sussman, MD Enrico O. Souto, MD Instructor of Clinical Medicine Susan S. Kais, MD

among the underserved population. His ongoing research seeks to evaluate novel screening methods, as well as identifying differences in genetic markers among racial/ ethnic groups in South Florida.

A BETTER DIAGNOSIS FOR PANCREATIC DISORDERS Diagnosis of pancreatic cysts has increased due to the wide availability of MRIs and CAT scans. The Division’s endoscopists perform the highest number of endoscopy ultrasounds in the state of Florida. They can now identify the type of pancreatic cyst or tumor, and may even be able to treat these cases. A leader in pancreatic disorders, Jamie Barkin, MD’s, work at the Medical Campus has allowed the Division to establish a center where patients with pancreatic disorders will be diagnosed and treated.

The Division offers a multi-disciplinary Gastrointestinal Cancer Prevention Clinic in collaboration with the Genetics Department, including the services of a genetic counselor for patients at risk for heritable gastrointestinal tract cancers such as colorectal cancer (CRC). These counselors offer testing and education for potential heritable cancer syndromes during which families are offered personalized risk management programs.

Daniel Sussman, MD’s, research reflects this interest in screening opportunities for CRC and biologic differences that may exist in gastrointestinal tumors in persons of varying racial/ethnic backgrounds. He recently co-authored a manuscript published in the Journal of the National Cancer Institute detailing the challenges, availability and utilization of CRC screening practices D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

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Division of General Internal Medicine A Fiscally and Medically Robust Division The Division of General Internal Medicine (GIM) faculty provides the bulk of adult primary care at UHealth, conducting more than 100,000 outpatient care visits in Fiscal Year 2014.

For the past 20 years, GIM faculty has been at the forefront of medical education. Since 2009, the Division has developed a robust portfolio of externally funded research through federal, state and foundation-sponsored projects. The faculty also serves as principal investigators on more than $15 million of externally sponsored awards.

The GIM Division remains exceptionally proud of its diverse faculty. At present, over 60% of clinicians hail from under-represented minority groups, and more than half of the faculty is women. Financially, Fiscal Year 2014 saw the Division exceeding its budget targets for the fifth year in a row. This is also the second year that the GIM Division was able to end with a surplus in funds.

The GIM Division has a heavy educational focus with several Divisional faculty having leadership roles in Undergraduate and Graduate Medical Education.

Examples include: Laurence Gardner, MD, former Chair of Medicine who now serves as Executive Dean for Education and Policy for UHealth; Alex Mechaber, MD, Senior Associate Dean for Undergraduate Medical Education: Yvonne Diaz, MD, Chief Academic Officer for UHealth; and Joan St. Onge, MD, Associate Dean for Graduate Medical Education. Division faculty also serve as directors of various UMMSM courses including Clinical Skills, Doctoring, Ethics Theme, the Generalist Primary Care Clerkship, Medicine Sub-internships, and various senior electives, including Professional Development, Transitions-to-Residency, and Student Free Clinic. Ross Scalese, MD, Assistant Director of Educational Research and Technology at the Gordon Center for Research in Medical Education, leads competency-based training and assessment of medical students and resident physicians and has also played a major role in the anti-terrorist training of health professionals. GIM faculty members, Mark O’Connell, MD, Senior Associate Dean for Medical Education and Meghan McNulty, MD, Chair of the Faculty Curriculum Steering Committee, both help lead components of UM’s MD/MPH program towards being the largest such four year program in the nation.

Lastly, several GIM faculty members serve as Associate

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Residency Program Directors and clinical educators for the residency program, including staffing two inpatient teaching teams at Jackson Memorial Hospital and directing the residency program’s continuity clinics.

GETTING THE MESSAGE OUT The GIM Division is dedicated to sharing its research and medical discoveries with a much larger audience and often looks to distribute its findings beyond the traditional mechanisms of scholarly publications read mostly by scientific and medical professionals. One example is Olveen Carrasquillo, MD, MPH, who is regularly featured in many Spanish-language television networks.

Another physician that consistently reaches out is Erin Marcus, MD, Associate Professor of Clinical Medicine.

Prior to medical school, Dr. Marcus was an accomplished journalist, and she continues to write articles about medically vulnerable populations in mainstream newspapers and magazines. Her articles and stories have appeared in publications such as The Atlantic, The Washington Post, The New York Times and The Miami Herald.

BRINGING HEALTH SOLUTIONS TO WOMEN This year, the National Cancer Institute-sponsored South Florida Center for the Reduction of Cancer Disparities completed recruitment of 600 Latina, Haitian and African-American women for a study aimed at increasing cervical cancer screening via community health worker led HPV self-sampling intervention. The study has shown that nearly 90% of women who had not been previously screened, get tested for cervical cancer when given the option to use this new approach of self-collecting samples.

PROVIDING COMMUNITY-WIDE CARE General Internal Medicine faculty provide care at six practices throughout Miami-Dade, Broward and Palm Beach counties. Clinical services range from providing primary and preventive care, managing chronic health conditions, providing care for acute illnesses and caring for patients with multiple advanced chronic health conditions. The Division also serves the medically indigent population at the Jackson Health System, which saw approximately 15,000 visits in Fiscal Year 2014.

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

DIVISION FACULTY LIST Professors of Clinical Medicine Panagiota Caralis, MD, JD Special Assistant to the Chief of Staff and Medical Director of the Women Veterans Health Program, Miami VA Health System Laurence Gardner, MD Executive Dean for Education and Policy Daniel Lichtstein, MD Regional Dean for Medical Education, University of Miami Miller School of Medicine Research Professor Kenneth Goodman, PhD Director, Bioethics Program & WHO Collaborating Center of Ethics and Global Health Policy Secondary appointments: Philosophy; Public Health Sciences Associate Professors of Clinical Medicine Keith Custer, MD Michael Federman, MD Medical Director, Palm Beach Gardens Practice Mark Gelbard, MD Director of PBL Curriculum for MD/ MPH Program Marco Gonzalez, MD Associate Division Chief Medical Director, GIM Faculty Practice at UMHC Erin Marcus, MD, MPH Associate Director, GIM Education at Jackson Memorial Hospital Secondary appointment: Public Health Sciences Alex Mechaber, MD Senior Associate Dean, Undergraduate Medical Education Hilit Mechaber, MD Associate Dean for Student Services Director, Honors Program in Medicine

Paul Mendez, MD Director, Clinical Skills Program Assistant Dean of Clinical Curriculum Mark O’Connell, MD Senior Associate Dean for Educational Development Bernard Fogel Chair in Medical Education Ana Palacio, MD, MPH Co-Director, Public Health in the Americas Center, Public Health Sciences Secondary appointment: Public Health Sciences Ross Scalese, MD Assistant Director of Educational Research and Technology at the Gordon Center for Research in Medical Education Joan St. Onge, MD Associate Dean for Graduate Medical Education Leonardo Tamariz, MD, MPH Director of the IRB, Veteran’s Affairs Hospital Director, Resident Scholarly Activity Program (RSAP) Secondary appointment: Public Health Sciences Frederick Williams, MD Program Director, UM Regional Campus Internal Medicine Program Judi Woolger, MD Medical Director, Executive Medicine Secondary appointments: Surgery; Neurosurgery; Orthopedics; Psychiatry Research Associate Professor Chi Zhang, PhD Assistant Professors of Clinical Medicine Gauri Agarwal, MD Howard Anapol, MD Medical Director, GIM Faculty Practice at Coral Gables

Olveen Carrasquillo, MD, MPH Division Chief Division Head, Health Services Research & Policy Professor of Medicine and Public Health Sciences

Monica Broome, MD Stefanie Brown, MD Vice Chair of Education, Department of Medicine Program Director, Internal Medicine-Pediatrics Residency Program Alexandra Calandriello, MD Gregory Coleman, MD Gloria Coronel-Couto, MD Yanisa Del Toro, MD Medical Site Educational Director, Internal Medicine Residency Program at UMHC/Sylvester Yvonne Diaz, MD Chief Academic Officer, UHealth Bruce Eisenberg, MD Antonia Eyssallenne, MD, PhD Associate Program Director, Internal Medicine-Pediatrics Residency Program, Program Director, Pediatrics Residency Program, Hospital Bernard Mevs/Hospital St. Damian, Haiti Alexis Federman, DO Robert Federman, MD Sherin Ghali, MD Lilliam Guzman, MD Medical Director, International Medicine Brian Hagenlocker, MD Chief, Clinical Informatics, Miami VA Health Care System Ben Hassan, MD Associate Program Director, Internal Medicine Residency Program at Jackson Memorial Hospital/University of Miami, Miami VA Health Care System Melanie Helfman, MD

Medical Director, CHDS Kendall Margarita Llinas, MD Sudha Lolayekar, MD Meaghan McNulty, MD, MPH Associate Director of MD/MPH Program Course Co-Director for: Doctoring; Physicianship; Integration of Public Health and Medicine; Community and Public Health Hiram Rodriguez, MD Maritza Suarez, MD Associate Vice Chair of Quality, Department of Medicine Assistant Chief Medical Information Officer, UHealth James Trice, MD Alan Yesner, MD Medical Director UHealth Boca Raton /Ft. Lauderdale Practices Associate Chief Patient Safety and Quality Officer, UMMG off site clinics Research Assistant Professors Reid Cushman, PhD Sonjia Kenya, PhD Secondary appointment: Public Health Sciences Instructor Aileen Chang, MD, MPH Fellow, HRSA Faculty Development Program

EDUCATING FOR THE FUTURE The General Internal Medicine faculty has several key clinical, research, educational and administrative roles in the Internal Medicine training program. They teach a wide spectrum of courses through lectures, small group discussions, problem-based learning, role playing, and simulations. Additionally, this past year faculty spearheaded a new residency program in Haiti, developed various education modules for medical students in Ecuador, and members are actively collaborating with medical students in Malaysia.

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offerings is the Resident Scholarly Activity Program (RSAP). Through this program, the Division has increased the rate of publication, and improved the quality of research projects by the house staff. Developed in 2009, the program evolved from sporadic individual lectures to a structured online and in-person framework. Since its start, RSAP residents have published and presented over 275 papers, and have a publication/presentation rate of 75%. In the coming year, plans for expansion include simulationbased research learning and the development of virtual mentoring communities.

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Division of Geriatrics and Palliative Medicine Improving the Quality of Life for those in their Golden Years The Division of Geriatrics and Palliative Medicine at the University of Miami, Miller School of Medicine is dedicated to the improvement of health, independence, and quality of life for older persons. The Division also focuses on reducing the burdens of dependent persons through interdisciplinary learning and discovery.

Divisional training and research activities are based on interdisciplinary care models established and maintained by nationally and internationally recognized faculty who serve as attending physicians at venues within the University of Miami as well as at the Miami VA Medical Center and the Miami Jewish Health Systems. Faculty members in the Division have a range of research interests including bone metabolism, diabetes, prostate cancer, regenerative medicine and palliative medicine.

SECURING FUNDING TO ENSURE THE HEALTH AND SAFETY OF OLDER PATIENTS Allen Andrade, MD, secured $190,000 in funding for a one year study that will provide self-management skills training to geriatric veterans with urinary incontinence and overactive bladder. Training will include individualized patient education and behavioral therapy.

In collaboration with the Tampa VA Healthcare System, Stuti Dang, MD, financed $171,000 for her one year project that evaluates the benefits of integrating

telehealth with home based primary care. Dr. Dang was also able to obtain VA funding for a project that will implement the internet site “MyHealtheVet” for veterans with heart failure. The long-term goal is to evaluate the added value of using the site as a case management platform for patient care.

Dr. Dang was also able to successfully fund a second year for her project evaluating brief, low-cost, internet and telephone skills-building intervention. The project, which involves testing the feasibility of intervention with Spanish-speaking caregivers, aims to reduce caregiver burden and depression, and improve veterans’ functional abilities. The program is expected to include online resources for stroke caregivers as well as provide an intervention strategy for clinicians throughout the VA to use in their practice.

Willy Valencia-Rodrigo, MD, funded a patient and family centered program that focuses on teaching vulnerable veterans how to exercise correctly in order to avoid high falls and institutionalization.

Jorge Ruiz, MD, was able to secure funding for $288,000 to provide individualized patient education and self-management training to chronically ill older veterans.

The approach makes use of information prescriptions as the catalyst for the provision of individualized health care information to chronically ill patients and caregivers on how to help manage health problems.

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Artist House West Indian manatees (Trichechus manatus) at Three Sisters Spring, National Wildlife Refuge in Crystal River, Florida by Robert M. Jackson, MD, FACP, Associate Chief of Staff for Research Miami VAHS, Professor of Medicine, Pulmonary & Critical Care, University of Miami Miller School of Medicine.

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EXCELLENCE IN GERIATRICS The Division recently received approval of the hospice and palliative medicine fellowship training program, under the leadership of Khin Zaw, MD. The Miami Geriatric Research, Education and Clinical Center (GRECC) is one of only 20 Centers of Excellence in Geriatrics in the U.S. The Miami GRECC, which was approved in 1991 to serve older adults in South Florida, has been continuously funded by the federal government at approximately $3 million a year.

BATTLING NON-SMALL CELL LUNG CARCINOMA A collaborative Miller School study led by Priyamvada Rai, PhD, Assistant Professor of Medicine in the Division of Geriatrics and Palliative Medicine, describes a novel therapeutic target in a common, but at present untreatable cancer. The study, “MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways,” published July 14 online ahead of print in Oncogene, describes a critical role for a protein (MHT1) in facilitating tumor formation. The study specifically focused on non-small cell lung carcinoma (NSCLC), a highly aggressive and treatment-resistant form of lung cancer.

“Using human tumor tissue samples, we found that MTH1 inhibition reduced tumor formation by those NSCLC cells containing a specific suppression protein,” Dr. Rai said. “Our study indicates that targeting the MTH1 protein may be sufficient to inhibit these non-small cell lung cancers”. Dr. Rai and her team are now planning pre-clinical studies to verify their results in an animal model.

RESEARCH HELPS EXPLAIN CAUSES OF RARE GENETIC DISORDER An international collaboration co-led by Ramiro E. Verdun, PhD, assistant professor of medicine in the Division of Geriatrics and Palliative Medicine, illuminates the underlying origins of a rare genetic disorder that causes an immune system deficiency syndrome known as

DIVISION FACULTY LIST Hermes Florez, MD, PhD, MPH Interim Division Chief Director, Division of Epidemiology Director, GRECC - Miami VA Healthcare System

Professors of Medicine Silvina Levis-Dusseau, MD Bruce Troen, MD (emeritus) Michael Mintzer, MD (emeritus) Associate Professors of Clinical Medicine Evan Paul Cherniack, MD Stuti Dang, MD, MPH Jorge G. Ruiz, MD Assistant Professors of Clinical Medicine Enrique Aguilar, MD Joel Danisi, MD Jenny Drice, MD Juan Carlos Palacios, MD

Osvaldo Rodriguez, MD Luis Samos-Gutierrez, MD Marcios Soares, MD Karin Zachow, MD Khin Zaw, MD Research Professor Guy Howard, PhD Research Associate Professors Carlos Perez-Stable, PhD Ramiro Verdun, PhD Research Assistant Professors Miriam Gutt, PhD Priyamvada Rai, PhD

hyper-IgM syndrome type 2 (HIGM2).

Patients with HIGM2 syndrome are unable to switch from the production of immunoglobulin M or IgM antibodies to IgG, IgE or IgA antibodies, which are essential for the body to fight infections. HIGM2 is usually caused by inactivation of an enzyme (named AID) that creates mutations in DNA and is responsible for triggering antibody switching, the DNA process needed to produce the different types of antibodies.

“The implication of our work is that uncoupling the DNA repair activity makes the modified form of the AID protein highly toxic for antibody-producing cells, leading to the immune system deficiency observed in HIGM2 patients,” Dr. Verdun stated. “Our research now focuses on manipulating the DNA repair mechanisms in antibody producing cells, with the ultimate goal of restoring antibody switching to normal levels in HIGM2 patients.”

Reducing the burdens of dependent persons D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

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Division of Hematology-Oncology Expanding Cancer Care throughout the South Florida Community The Division of Hematology-Oncology is engaged in the treatment and clinical, basic and translational research related to benign and malignant hematologic diseases, and solid tumors. The Division provides expert hematologic-oncologic care at the Sylvester Comprehensive Cancer Center and affiliated clinics in Miami, Kendall, Coral Springs, Hollywood, Plantation, Deerfield Beach, and at Jackson Memorial Hospital, University of Miami Hospital, and the Miami Veterans Administration Hospital. Since 2001, the Division has experienced remarkable expansion in clinical and research activities, including an increase in new patients seen at UMHC Sylvester annually, from 2,600 in 2007 to over 5,300 new patients in 2014.

Hematology-Oncology Division faculty members provide state-of-the-art multidisciplinary care, and many are nationally recognized. In addition, they are prominent researchers in the Department of Medicine and the Sylvester Comprehensive Cancer Center. UM hematologist-oncologists have made seminal contributions towards understanding the pathogenesis of leukemia, lymphoma, HIV-1 associated malignancies, breast, prostate and pancreas cancers, sarcomas, coagulation and thrombotic disorders. Providing a wide range of novel therapeutic options through the conduct of over 150 therapeutic clinical trials, the Division takes special pride in the diversity of its multi-lingual faculty and staff which mirrors the diversity of South Florida.

STEM CELL TRANSPLANTATION AT SYLVESTER The Bone Marrow Transplant Program relocated to a state-of-the-art facility at the Sylvester Comprehensive Cancer Center in 2011, and has expanded rapidly under the able leadership of Krishna Komanduri, MD, PhD. Dr. Komanduri has completely reorganized clinical and research activities within the Stem Cell Transplantation Program since his arrival in 2008, and has recruited Lazaros Lekakis, MD, to assist in program development.

The program performs autologous and allogeneic transplants from related and unrelated donors, as well as cord blood transplants, and received outstanding evaluations during FACT accreditation inspections in 2010 and 2013. Under Dr. Komanduri’s leadership, the number of stem cell transplants has increased dramatically from a total of 48 annually in 2009 to 160 transplants projected for 2014.

PERSONALIZING SARCOMA TREATMENT The University of Miami is a center of excellence for the treatment of sarcomas and related malignancies.

Jonathan Trent, MD, Professor of Medicine and leader of the Sarcoma Site Disease Group, arrived in 2011 from MD Anderson Cancer Center followed by Breelyn Wilky, MD, who joined the Division from John’s Hopkins University in 2013. Dr. Trent is a nationally recognized expert on gastrointestinal stromal tumors (GIST). His laboratory is studying the use of signal transduction inhibitors in GIST and other sarcomas, and developing novel treatment approaches. Dr. Trent has also assumed a high profile role within the Cancer Center as the Associate Director for Clinical Research, overseeing expansion and development of Cancer Center infrastructure supporting clinical trials. Together, Drs. Wilky and Trent have assembled a compelling portfolio of pharmaceutical and investigatorinitiated clinical trials for sarcoma.

Stephen Nimer, MD, Professor or Medicine, Biochemistry and Molecular Biology; Director of the Sylvester Comprehensive Cancer Center and internationally known leukemia expert, joined the Hematology-Oncology Division in 2012

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BREAST CANCER: A HOLISTIC APPROACH Reshma Mahtani, MD, Chuck Vogel, MD, & Mohammad Jahanzeb, MD, have developed a unique breast cancer clinic in Deerfield Beach embodying a holistic approach towards mind-body-and spirit. The clinic incorporates diet, acupuncture, aroma therapy, mindfulness and other interventions to improve a patient’s sense of well-being.

PREDICTING OUTCOMES AND TAILORING THERAPY IN LYMPHOMA The Lymphoma Program has made continued advances in understanding pathogenesis and in the development of new treatment strategies under the leadership of Izidore Lossos, MD. Building upon a novel 6 gene model Dr. Lossos developed for treatment prognostication, his laboratory has characterized the biology of H-GAL (human germinal center associated lymphoma), and LMO2, key biomarkers which help predict clinical outcomes in diffuse large B cell lymphoma.

Working with Juan Carlos Ramos, MD, of the SCCC Viral Oncology program, they have identified CD30 as a target for the treatment of primary effusion lymphoma (PEL), a particularly lethal lymphoma seen in the setting of HIV-1 infection, using brentuximab vedotin.

Brentuximab, an anti-CD30 antibody drug conjugate recently approved by the FDA for use in relapsed Hodgkins disease and anaplastic large cell lymphoma, is based on a targeting antibody developed in the SCCC. Initial Phase I /II testing was carried out at UM by Joseph Rosenblatt, MD, leading to FDA approval. Dr. Ramos has also developed an additional approach to PEL, combining proteasome inhibition and epigenetic therapy using HDAC inhibitors, recently published in the Journal of Clinical Investigation. Dr. Ramos continues to play a national leadership role in the AIDS Malignancy Consortium and is principal investigator on a variety of trials catering to the unique HIV-1+ patient population served at UM hospitals.

DIVISION FACULTY LIST Joseph D. Rosenblatt, MD Division Chief Department of Medicine Professor of Medicine, Microbiology & Immunology William J. Harrington Chair in Hematology

Professors of Medicine Yeon Soong Ahn, MD Bach Ardalan, MD Pasquale Benedetto, MD John Byrnes, MD Lynn Feun, MD Krishna Komanduri, MD Marc Lippman, MD Izidore Lossos, MD Stephen Nimer, MD Stephen Richman, MD Joyce Slingerland, MD Jonathan Trent, MD, PhD Professors of Clinical Medicine Judith DeLeo, MD Mohammad Jahanzeb, MD Charles Vogel, MD Associate Professors of Medicine Ram Agarwal, MD Dorraya El-Ashry, PhD Merchan, Jaime, MD Abdul Mian, PhD Rakesh Singal, MD Donald Temple, MD Associate Professors of Clinical Medicine Mark Goodman, MD Chukwuemeka Ikpeazu, MD Juan Ramos, MD Ariel Lopez-Chavez, MD Orlando Silva, MD Catherine Welsh, MD Assistant Professors of Medicine Ronan Swords, MD, PhD Justin Watts, MD Breelyn Wilky, MD

Assistant Professors of Clinical Medicine Nicolas Acquavella, MD Ikechukwu Akunyili, MD Timothy Aliff, MD Ney Alves, MD Sharhabil Ammus, MD Roberto Cano, MD Vy Dinh, MD Gustavo Fernandez, MD Deborah Glick, MD Thomas Harrington, MD James Hoffman, MD Lazaros Lekakis, MD Reshma Mahtani, DO Raja Mudad, MD Lawrence Negret, MD Denise Pereira, MD Agustin Pimentel, MD Maria Restrepo, MD Pearl Seo, MD Alexandra Stefanovic, MD Frances Valdes-Albini, MD Steven Weiss, MD Israel Wiznitzer, MD Research Professors Niramol Savaraj, MD Arthur Zelent, PhD Research Associate Professors Wenche Jy, PhD Seung-Uon Shin, PhD Eric Wieder, PhD Research Assistant Professors Cara Benjamin, PhD Xiaoyu Jiang, PhD Subbarayan Pochi, PhD Ye Xu, PhD Yu Zhang, PhD

Remarkable expansion in clinical and research activities D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

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Division of Hepatology Leading the Way with Robust Clinical Programs and Innovative Patient Care In addition to evaluating and caring for patients with diseases of the liver, the Division of Hepatology works tirelessly to research a variety of treatment options and discover breakthrough therapies.

Providing care at all sites on the Medical Center Campus, the Division of Hepatology boasts a very active clinical program and has established an inpatient teaching service at the University of Miami Hospital (UMH). Consultations are also provided at every location on the medical campus.

NEW HEPATOLOGY FELLOWSHIP PROGRAM ENCOURAGES SPECIALIZATION IN THE FIELD

GROUNDBREAKING RESEARCH YIELDS PROMISING NEW THERAPIES FOR LIVER DISEASE

FOUND: A CURE FOR HEPATITIS C

The Division of Hepatology is also involved in multicenter and investigator-initiated clinical research, and faculty continues to research improved methods of treatment for other significant causes of liver disease. One example is the longstanding interest in hepatitis B and C infection which inspired Eugene Schiff, MD, Lennox Jeffers, MD and Christopher O’Brien, MD, to investigate the role of antiviral therapy.

Cynthia Levy, MD, has developed a program focused on the management of cholestatic liver disease, exploring novel approaches with a variety of new agents to ameliorate injury to the bile ducts, the major site of disease in these disorders.

Faculty members Ram Bhamimidarri, MD, and Adam Peyton, MD, are among the Division’s experts in managing hard-to-treat populations with hepatitis C. Maria Hernandez, MD, who recently joined the Division, helps treat HCV in HIV co-infected individuals.

With its main focus being education and clinical research, the Division also has an accredited one year fellowship for trainees who have already completed gastroenterology and wish to pursue a career in hepatology.

This newly accredited fellowship encourages trainees to pursue a career in academic medicine.

The Division is one of only 12 sites nationally that offers third-year gastroenterology fellows this opportunity.

One of the most exciting developments has been the licensing of new medications to treat hepatitis C. These treatments allow for a cure, regardless of how many years a patient has been infected or the number of prior unsuccessful attempts at managing the disease.

Many patients who were previously unable or unwilling to attempt therapy due to its multiple side effects can now find a cure by simply taking these new alloral medications. Several faculty members served as investigators for these clinical trials.

UM DOCTOR CONTRIBUTES TO THE CREATION OF ONLINE TREATMENT GUIDELINES A strong impetus for the use of these new regimens has been the availability of online treatment guidance developed jointly by experts from the American Association for the Study of Liver Disease and the Infectious Disease Society of America. UM’s own Paul Martin, MD, Division Chief, was among those who contributed to the creation of these guidelines.

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Iguana in the Dutch Antilles on the island of Bonaire by Marc Lippman, MD, MACP, FRCP, Leonard M. Miller Professor of Internal Medicine, Psychiatry and Behavioral Sciences and Deputy Director, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine

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BRINGING HOPE AND WORLD-CLASS CARE TO LIVER TRANSPLANT PATIENTS… The Division of Hepatology is also proud of the clinical achievements made with the liver transplant program of the Miami Transplant Institute, which boasts excellent patient outcomes. Members of the faculty, including Christopher O’Brien, MD, Ram Bhamimidarri, MD and Adam Peyton, MD, play a key role in providing clinical care which offers life-saving therapy to patients who would otherwise die of liver disease.

…HOWEVER, LIVER DISEASE DOESN’T ALWAYS REQUIRE A TRANSPLANT

DIVISION FACULTY LIST Paul Martin, MD Division Chief Professor of Medicine

Professors of Medicine Lennox Jeffers, MD Eugene Schiff, MD

Associate Professor of Clinical Medicine Cynthia Levy, MD

Professor of Clinical Medicine Christopher O’Brien, MD

Assistant Professors of Clinical Medicine Kalyan Ram Bhamidimarri, MD Adam Peyton, MD Maria Hernandez, MD

The Division’s approach to holistic care can be seen in its treatment of cirrhosis. Optimal management of a liver tumor requires a multidisciplinary approach, which may include ablation, resection or chemotherapy. In these situations, the Division coordinates carefully to cure the tumor and address the underlying cause using anti-viral therapy, in cases of hepatitis C, or a liver transplant in cases of liver failure.

THE SCHIFF CENTER Named for Leon Schiff, MD, the first president of the American Association for the Study of Liver Diseases, the Schiff Center for Liver Diseases embraces both clinical and basic research.

The center has been home to major research for hepatitis C, including one boasting a cure rate of over 95%. Many of these trials have been published and ongoing drug trials continue with the goal of eradicating the hepatitis B virus in the body, helping patients attain a real cure.

New drugs for chronic cholestatic disorders, the genetic patterns of liver diseases, and the artificial liver support of severe alcoholic hepatitis patients continue to be carefully studied. With definitive cures for hepatitis C and B, the emphasis is now on evaluating other agents that reduce inflammation to stop the progression of liver fibrosis and cirrhosis.

Future plans for laboratory research includes genomics, stem cells, and nanoparticles, which will be carried out in collaboration with the Department of Cell Biology and other research centers.

Top: Drs. Leon and Eugene Schiff Above: Eugene Schiff, MD

Eugene R. Schiff, MD, MACP, FRCP, MACG, AGAF, FAASLD, Leonard Miller Professor of Medicine, Dr. Nasser Ibrahim Al-Rashid Chair in the Schiff Center for Liver Diseases, Director, Schiff Center for Liver Diseases, Director, Hepatology Research Laboratory

Redefining care for liver disease patients

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Division of Hospital Medicine With exceptional faculty and first-rate service, Hospital Medicine shines Hospitalists function as primary care physicians when a patient is first admitted to the hospital. From creating the initial plan of care, to coordinating with specialists; a Hospitalist prepares a patient’s safe discharge and ensures all patients receive the highest quality care with superior outcomes. This mission is at the core of the Division’s promise to both patients and referring physicians.

The Faculty of the Division of Hospital Medicine is recognized as leaders in Hospital Medicine education locally and nationally. Locally, the faculty excels at the Internal Medicine Residency program at Jackson Memorial Hospital with Joshua Lenchus, DO, RPh, FACP, SFHM and Jessica Zuleta, MD, FHM, as Associate Program Directors. Nationally, the Division is a leader at publishing information regarding quality improvement and patient safety, medical education, and perioperative medicine.

The Division’s final mission is service and leadership.

Nationally, members of the faculty serve on editorial boards and as reviewers of multiple journals. They also work with multiple committees and hold leadership roles within the Society of Hospital Medicine, the American College of Physicians, and the Society of General Internal Medicine. Members of the senior leadership at both Jackson Memorial Hospital and University of Miami Hospital work tirelessly to advocate for patients.

As citizens of the hospitals they serve, members of the Division faculty are also the chairpersons of many of the most important committees at the University of Miami and Jackson Memorial Hospitals. One example of this is Dr. Joshua Lenchus, who is currently serving as the President of the Medical Staff at Jackson Memorial Hospital.

AN IMPORTANT ROLE FOR DIVISION CHIEF Efren Manjarrez, MD, is the assistant CMO at University of Miami Hospital and is part of a national task force to find the key to optimal control of diabetes in hospitalized medically and surgically unstable patients.

THE UNIVERSITY OF MIAMI HOSPITAL: THE DIVISION’S FLAGSHIP PRACTICE UMH provides coverage to two academic teaching teams and two faculty direct non-teaching services specializing in the co-management of Cardiology/Cardiothoracic surgery patients and complex Hematology/Oncology patients. Additionally, the Division, whose quality metrics are near 100%, provides an internal medicine consult service while nocturnist service ensures that there is a continuous presence of faculty at night to provide seamless care.

Joshua Lenchus, DO, RPh. FACP, SFHM

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NOVEL BEDSIDE PROCEDURE OFFERING THE MOST POPULAR ROTATION At Jackson Memorial Hospital, the Division provides an Internal Medicine Consult Service and a novel Bedside Procedure Service. The Consult Service is a teaching program that provides round-the-clock advice to surgical patients with medical diagnoses. The Division’s Bedside Procedure Service remains the most popular rotation in the Internal Medicine Residency. Created by Joshua Lenchus, MD, the Bedside Procedure Service has received more than $1.3 million in grants.

AMONG THE NATION’S BEST PREOPERATIVE CARE Another unique program is the University of Miami Preoperative Assessment Center (UPAC). One of the few such centers of its kind, UPAC patients receive a combined Internal Medicine and Anesthesia preoperative risk assessment prior to surgery.

The Division of Hospital Medicine also contributes to the nation’s foremost eye hospital, the Bascom Palmer Preoperative Assessment Clinic, by having hospitalists oversee a preoperative clinic staffed by nurse practitioners and physician assistants for low to moderate risk medical patients.

DIVISION FACULTY LIST Efrén Manjarrez, MD, SFHM Interim Division Chief Associate Chief Medical Officer, University of Miami Hospital Assistant Professor of Clinical Medicine

Professors of Medicine Steven Cohn, MD, FACP, SFHM Medical Director, UHealth Preoperative Assessment Center (UPAC) Medical Director, UMH Medical Consultation Service Barry Materson, MD, MBA Academic Mentor, Hospital Medicine Associate Professor of Clinical Medicine Joshua Lenchus, DO, RPh, FACP, SFHM President, Jackson Health System Medical Staff Associate Program Director, Jackson Memorial Hospital Internal Medicine Residency Associate Director, UM-JMH Center for Patient Safety Assistant Professors of Clinical Medicine Syeda Uzma Abbas, MD, MPH Medical Director, University of Miami Hospital Win Aung, MD, DM, MBA, FRCP Director, Clinical Operations

Jorge Florindez, MD German Giese, MD Sharon Goldberg, MD Ashwin Mehta, MD, MPH Medical Director, Integrative Medicine Shreevinaya Menon, DO Deepak Mummidavarapu, MD Rene Parraga-Montilla, MD Sub Internship Clerkship Director at University of Miami Hospital, Hospital Medicine Clinical Skills MD MPH Clerkship Director at University of Miami Hospital, Hospital Medicine Aldo Pavon Canseco, MD Medical Director, Bascom Palmer Sarahi Rodriguez-Perez, MD Juan Reyes, MD, MPH Candice Aurelus Sternberg, MD Jessica Zuleta, MD, FHM Education Director, Hospital Medicine Associate Program Director, Jackson Memorial Hospital Internal Medicine Residency

DR. COHN TEACHES PHYSICIANS ABOUT PATIENT RISK DURING MAJOR SURGERY

Steven L. Cohn, MD, FACP, SFHM

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

“Medically clear for surgery” is a phrase Steven L. Cohn, MD, FACP, SFHM will never use.

As a world-renowned expert in perioperative medicine, Dr. Cohn has dedicated his career to improving the care of patients undergoing surgery. He has spent almost 30 years teaching physicians how to evaluate and reduce the risk of patients with heart disease undergoing major surgery.

Dr. Cohn’s message is simple: all a doctor can do is determine whether a patient is medically optimized for surgery.

Each year, Dr. Cohn is asked to speak at the national meetings of various prestigious medical organizations, as a foremost expert on perioperative medicine. Dr. Cohn’s findings will soon be published in a chapter entitled “Preoperative Evaluation” in the prestigious Cecil’s Textbook of Internal Medicine.

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Division of Infectious Diseases Well-Funded Research Programs The Division has internationally renowned research programs focusing on the management of HIV/AIDS, and AIDS and Hepatitis C prevention. Faculty has secured $14 million to fund 47 active grants for Fiscal Year 2015.

Some of these research projects will tackle HIV care and access, prevention, Hepatitis-C co-infection, transplant, and global research.

The faculty engages in strong collaborative efforts with colleagues to enhance the research missions of the Department of Medicine. One example is the Center for AIDS Research (CFAR). The University of Miami’s CFAR is one of 17 federally-funded CFARs in the United States, and the only one in Florida. Mario Stevenson, MD, and Margaret Fischl, MD, serve as co-directors of the CFAR, which has clinical and research cores that support the activities of investigators engaged in AIDS-related research. Michael Kolber, MD, and Allan Rodriguez, MD, help coordinate CFAR activities centered on HIV prevention and behavior, while Maria Alcaide, MD, directs a CFAR peer-mentoring program.

Infectious disease research is sponsored by federal and state agencies including: NIH, CFAR, CDC, and other pharmaceutical company sponsors. The Division continues to establish an infrastructure that promotes bench-to-bedside translational research as well as patient-based studies. This infrastructure enhances the competitiveness of the faculty and assists them in garnering additional funding.

Through leadership positions in the AIDS Institute and the CFAR, the faculty is committed to helping improve the lives of individuals afflicted by acute and chronic infectious pathogens.

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HOSPITAL EPIDEMIOLOGY AND INFECTION PREVENTION The Division is committed to patient safety and providing expertise and leadership to the Infection Prevention programs of the UHealth system, Jackson Memorial Hospital, and the Miami VA Healthcare system. In addition to basic Infection Prevention activities, faculty members Rafael Campo, MD, Jose Castro, MD, and Thomas Hooton, MD, have led efforts to establish a mandatory influenza vaccination program at UHealth and to prepare hospitals and clinics for Ebola screening and management.

FINDING OPPORTUNITIES AT HOME AND ABROAD The Division continues to excel at funding research activity and provides strong outreach as a major component of its mission. Faculty engage in clinical care and educational activities with partnering Health Centers in Haiti, Guatemala, Colombia, Dominican Republic and Brazil, and these activities provide outstanding training opportunities for fellows. The Division also benefits from the participation of courtesy faculty who engage in clinical service and advisory roles. For example, Professor Raymond Schinazi, MD, who has pioneered the development of antiviral agents for the treatment of HIV-1 and Hepatitis-C infection, serves as a member of the courtesy faculty and scientific advisory boards of the Center for AIDS Research and the University of Miami AIDS Institute.

Pygmy seahorse from Wakatobi, Indonesia

by Marc Lippman, MD, MACP, FRCP, Leonard M. Miller Professor of Internal Medicine, Psychiatry and Behavioral Sciences and Deputy Director, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine

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U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

RESPONDING TO THE EBOLA CRISIS The Ebola Virus is a lethal human pathogen that has a high fatality rate. Previous outbreaks were confined to remote regions of central Africa. However, the most recent outbreak that started in February 2014 in Guinea, West Africa was the largest and deadliest outbreak to date. In the United States, the two imported cases have highlighted the need to develop a plan to identify, treat and prevent further spread of Ebola.

The Division of Infectious Diseases has been at the center of the development and implementation of plans for the University of Miami Health System, Jackson Health System and the Veterans Administration Healthcare System. Current Ebola preparation activities involve the collaboration and coordination of professionals from diverse disciplines.

Little was known about Ebola prior to this most recent outbreak, and best practices to prevent the spread of this disease have evolved rapidly. Members of the Division of Infectious Diseases are central to UM’s comprehensive Ebola preparation effort.

INVESTIGATING HIV/AIDS IN SOUTH FLORIDA The Division has strong programs in research, clinical care, outreach and education. Research activities focus on diseases that have a disproportional impact on people in South Florida, in particular, HIV/AIDS. The Division has internationally recognized investigators working on federally-funded programs aimed at understanding the molecular basis of infectious diseases, their prevention and management. Faculty members also serve in leadership roles that are central to the medical school’s missions.

The Division has positioned itself effectively in the provision of HIV care to the growing Medicaid population through enhanced provider and house staff education.

Examples of this include funding through the AIDS Education and Training Center and the establishment and continuation of fellow and resident outpatient HIV clinics.

ANTIMICROBIAL STEWARDSHIP PROGRAM The Infectious Diseases Division leads efforts throughout the medical campus to preserve the efficacy of antimicrobials and prevent the development of resistance by promoting the careful, appropriate, and judicious use of antimicrobials.

Antimicrobial resistance is a global problem, with up to 50% of antimicrobial use being unnecessary or inappropriate. The Antimicrobial Stewardship Program

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DIVISION FACULTY LIST Mario Stevenson, PhD Division Chief Professor of Medicine

Professors of Medicine Michael Kolber, MD, PhD Vice Chair for Clinical Affairs Department of Medicine, Director Comprehensive AIDS Program, Director Adult HIV Services Department of Medicine Gordon Dickinson, MD Section Head, Division of Infectious Diseases, Miami VA Margaret Fischl, MD Director, AIDS Clinical Research Unit, Co-Director Miami Center for AIDS Research Professors of Clinical Medicine Thomas Hooton, MD Clinical Director ID, Medical Director of U-Health Infection Control and Employee Health, Chief of Medicine, Miami VA Rafael Campo, MD Dushyantha Jayaweera, MD Associate Vice Provost for Human Subjects Research Allan Rodriguez, MD Director of Behavioral/Social Science & Community Outreach Core CFAR Associate Professors of Clinical Medicine Lilian Abbo, MD Associate Chief U-Health Patient Safety and Quality Officer Medical Director Antimicrobial Stewardship Programs U-Health/JMH

Maria Alcaide, MD Gio Baracco, MD Chief, Infection Control, Miami VA Catherine Boulanger, MD Jose Castro, MD Luis Espinoza, MD Michele Morris, MD Director, Immunocompromised Host Section Isabella Rosa-Cunha, MD Stephen Symes, MD Assistant Dean for Diversity and Multicultural Affairs Program Director, Internal Medicine Training Program Assistant Professors of Clinical Medicine Hector Bolivar, MD Jose F. Camargo, MD Susanne Doblecki Lewis, MD Fellowship Training Program Director Paola Lichtenberger, MD Fellowship Training Program Co-Director Alexis Powell, MD Antoine Salloum, MD Jacques Simkins-Cohen, MD Research Assistant Professor Mark Sharkey, PhD

(ASP) works to improve patient safety by maximizing clinical cure or prevention of infection while limiting the unintended consequences, such as the development of resistance.

Antimicrobial expenditures at UMH significantly decreased with the addition of a designated ASP pharmacist and an ASP dedicated physician, Lilian Abbo, MD. The Division faculty provides leadership to the antimicrobial stewardship programs at UHealth, Jackson Memorial Hospital and the Miami VA.

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Division of Nephrology and Hypertension Providing Excellent Diagnosis and Care for Kidney Disease Patients The Division of Nephrology and Hypertension’s mission is to enhance the health of patients who are suffering from kidney disease through excellence in clinical medicine, research, and graduate and postgraduate training.

Sixteen full-time and three voluntary faculty members provide clinical care in all aspects of nephrology at the University of Miami Hospital, Jackson Memorial Hospital, the VA Medical Center, the Sylvester Comprehensive Cancer Center, and ambulatory facilities on campus and throughout the community.

WORLD-CLASS FACULTY The faculty has contributed to the scientific body of knowledge with more than 50 peer-reviewed publications in the last year, many of them appearing in the most prestigious scientific journals. Our fellowship training program attracts highly qualified candidates from throughout the country, and provides in-depth clinical education in general nephrology. The program also offers advanced training in transplantation and interventional nephrology.

the Miami Transplant Institute and the Division of Nephrology. This partnership led to the identification of a potential treatment for the disease in a selected group of biomarker positive patients, and further served to usher in a new era of personalized treatment strategies in nephrology.

AWARD-WINNING RESEARCH Our basic science research faculty members are affiliated with the Peggy and Harold Katz Family Drug Discovery Center, which is directed by Alessia Fornoni, MD, PhD. The Katz Center has successfully trained graduate students and post-doctoral fellows from five different continents, and actively fosters collaborations across campus, as well as nationally and internationally. Our graduate students are recipients of federal and agency training grants, have received a number of travel awards, and are continually presenting their findings at scientific meetings throughout the U.S. and Europe.

TACKLING THE UNWANTED SIDE-EFFECTS OF KIDNEY TRANSPLANTS The Division of Nephrology at the University of Miami has been among the most productive scientific Divisions both in the United States and worldwide in discovering new therapies that target the cure of focal and segmental glomerulosclerosis (FSGS) before and after transplantation. FSGS is a disease affecting both children and adults that often presents after kidney transplantation.

Inspired by two landmark studies describing a new mechanism in transplant-related FSGS (Nature Medicine and Science TM 2011), a partnership was created between

Alessia Fornoni, MD, PhD

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FOCUSING ON KIDNEY PATIENTS WITH LUPUS AND HIGH BLOOD PRESSURE Gabriel Contreras, MD, MPH, has a strong interest in clinical trials focusing on patients with high blood pressure and those with lupus complicated by kidney disease. Dr. Contreras was instrumental in several multicenter clinical trials focusing on treatment options for patients with hypertension and kidney disease due to systemic lupus erythematosus (SLE). His 2004 landmark article in the New England Journal of Medicine helped shape treatment options for those with SLE-induced kidney disease. More recently, he was able to demonstrate that transplantation was an excellent option for patients, even those from minority populations, with kidney failure due to SLE.

TREATING POST-TRANSPLANT PATIENTS WITH NEW DRUG THERAPY Alessia Fornoni, MD, PhD, and her team conducted ground-breaking diabetes-related research with the support of the Diabetes Research Institute. They work in close collaboration with George Burke III, Scientific Director, Miami Transplant Institute, to run a NIHsponsored clinical trial for the use of a new medication to prevent FSGS. This disease, which can affect children and young adults, often responds poorly to traditional treatment options and is characterized by a large amount of protein in the urine, leading to disabling swelling (edema), early cardiovascular disease, and progressive kidney failure often requiring dialysis or transplantation.

A landmark article in the New England Journal of Medicine (December 2013) highlighted a potential new drug therapy for patients with this difficult to treat disease. The discovery by Dr. Fornoni and Sandra Merscher, PhD, of how to better tackle FSGS resulted in their findings being published in the Journal of the American Society of Nephrology in early 2014. In order to identify those drugs with a high probability of success, Dr. Fornoni utilizes clinical observations to drive basic scientific discovery. Her end goal is to promote a personalized-medicine approach to patient care.

DIVISION FACULTY LIST Oliver Lenz, MD, MBA Interim Division Chief Professor of Clinical Medicine

Professors of Medicine David Roth, MD Clinical Director Leopoldo Raij, MD

Associate Professor of Medicine Alessia Fornoni, MD, PhD Director, Peggy and Harold Katz Family Drug Discovery Center

Professors of Clinical Medicine Gabriel Contreras, MD, MPH Kupin Warren, MD

Assistant Professors of Clinical Medicine Adela Mattiazzi, MD Jair Munoz Mendoza, MD Fernando Pedraza, MD

Associate Professors of Clinical Medicine Jorge Diego, MD Dollie Green, MD Giselle Guerra, MD Ali Nayer, MD Loay Salman, MD Ivonne Schulman, MD

Research Assistant Professors Christian Faul, PhD Sandra Merscher, PhD Instructor Ian Thomas, MD

NEW AND IMPROVED IMMUNOSUPPRESSIVE TREATMENTS In collaboration with the Miami Transplant Institute, transplant nephrologists Giselle Guerra, MD, Warren L. Kupin, MD, Adela Mattiazzi, MD, and David Roth, MD, continue investigating novel immunosuppressive treatment strategies for patients undergoing kidney transplantation.

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Division of Pulmonary, Allergy, Critical Care and Sleep Internationally Recognized Pulmonary Faculty and Programs The Division of Pulmonary, Allergy, Critical Care and Sleep Medicine provides a full array of clinical services and research activities that have attained national and international recognition.

The Division’s programs include the Interstitial Lung Disease program, which is a leader in the use of stem cells, pioneering their use for interstitial lung disease. The Cystic Fibrosis Center is nationally accredited and its clinical trial efforts facilitated the FDA approval of a breakthrough medication that directly targets the genetic defect present in cystic fibrosis patients.

The Non-Cystic Fibrosis Bronchiectasis Center, part of the Primary Ciliary Dyskinesia (PCD) Foundation’s Clinical Network, is nationally recognized for its efforts to improve treatments for these patients. Clinical trials are currently focused on inhaled antibiotics and the development of instruments to assess quality of life.

The Asthma Center provides clinical care and conducts research to improve the lives of those suffering from asthma.

The Lung Cancer Screening, Diagnosis and Treatment Center provides a full array of services, including bronchoscopy and biopsy procedures. Lastly, the Sleep Center provides sleep disorder assessments and clinical trials that diagnose and treat these diseases.

Many of these programs are funded through federal, state, foundation, and philanthropic resources.

USING NOVEL THERAPIES TO TREAT LUNG DISEASE Idiopathic pulmonary fibrosis (IPF) is characterized by severe shortness of breath and scarring of the lungs.

Various clinical trials were conducted and one multicenter in particular, led to the FDA approval of a new medication. This research has helped the national effort for longer symptom-free survival in patients with IPF.

BACK TO BASICS—FIGHTING INFECTIONS Infections acquired in health-care facilities are one of the leading causes of death in U.S. hospitals. Exposure to the hospital environment is often a risk factor, especially in Intensive Care Units (ICU). The Division focuses, as part of a national consortium, on the prevention and treatment of severe ICU-acquired infections by having all employees use the proper hospital gowns and gloves, as well as thorough hand washing, prior to being in contact with patients.

SLEEP CENTER Alex Abreu, MD, is leading the sleep center’s clinical operations and its fellowship program. More than 4,700 clinic visits and 2,350 sleep studies were performed during Fiscal Year 2014, representing a 25% increase in comparison to Fiscal Year 2013.

The Sleep Center has engaged in multiple research projects, many of which have been published in internationally-recognized Sleep Journals, as well as presented in the yearly National Sleep Medicine Meeting.

TACKLING THE CAUSES OF COPD Alpha one antitrypsin deficiency is a risk factor for developing severe chronic obstructive pulmonary disease (COPD). The lack of alpha one antitrypsin, a protein that usually protects from excessive inflammation in the lungs and airways, allows inflammation to go unchecked, thereby leading to emphysema and airway disease. The Division’s COPD Center is actively involved in finding improved treatments for these patients.

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Gulls on Siesta Key near Sarasota, Florida by Marc Lippman, MD, MACP, FRCP, Leonard M. Miller Professor of Internal Medicine, Psychiatry and Behavioral Sciences and Deputy Director, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine

U H ea l t h | U n i v er s i t y o f M i a m i M i l l er Sch o o l of Med i c i ne

WORKING TOGETHER TO FIGHT CYSTIC FIBROSIS The Pulmonary Division offers specialized care to adult patients with cystic fibrosis (CF) and bronchiectasis not associated with CF. Since cystic fibrosis is a multi-organ system disease, close collaborations exist between the Center run by pulmonary faculty and the Division of Endocrinology, Diabetes and Metabolism and the Division of Gastroenterology. Additionally, the Center collaborates heavily with the Pulmonary Division of the Department of Pediatrics.

All clinical research at the CF Center is coordinated between the adult and pediatric program and funded through the Therapeutic Development Network and multiple pharmaceutical companies. Clinical research is also conducted in collaboration with Alexandra Quittner, MD, who is a world-class expert in developing quality of life instruments. Clinical research is coordinated by Eliana Mendes, MD. Grants supporting these activities include support from the CF Foundation (Cystic Fibrosis Core Center, Therapeutics Development Center, and Restoring Cystic Fibrosis Airway Hydration by Inhibiting TGF-ß to M. Salathe), FAMRI (Role of K+ Channels and ATP in Chronic Bronchitis to M. Salathe) and the NIH (Airway Epithelial Repair in Chronic Bronchitis Novel Signaling Mechanisms to A. Schmid).

ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD) PROGRAM The Alpha-1 Program provides specialized patient care for those with alpha-1 antitrypsin deficiency (AATD), a genetic condition that predisposes individuals to develop liver and lung disease such as COPD, emphysema and bronchitis.

The program, led by Michael Campos, MD, and Adam Wanner, MD, works closely with the Alpha-1 Foundation, sharing the common goals of care, disease awareness and research to improve the quality of life of affected individuals and pursue novel therapeutic approaches.

DIVISION FACULTY LIST Matthias A. Salathe, MD Division Chief; Vice Chair for Research Director, Cystic Fibrosis Center; Director, UM Adult Clinical Translational Research Site Sertel Chair in Pulmonary Diseases Professor of Medicine Professors of Medicine Horst J. Baier, MD, JD Director, Respiratory Therapy & Bronchoscopy Services Director, Pulmonary & Critical Care Fellowship Program Professor of Medicine Marilyn K. Glassberg-Csete, MD Vice Chair for Innovation and Diversity Director, Interstitial Lung Disease Program Director, Pulmonary Disease at Interdisciplinary Stem Cell Institute Professor of Clinical Medicine Daniel H. Kett, MD Director, JMH MICU Professor of Clinical Medicine Robert M. Jackson, MD Professor of Medicine Andrew A. Quartin, MD Director, Critical Care Fellowship Program Professor of Clinical Medicine Roland MH. Schein, MH, MD Section Chief Critical Care at the VA Professor of Medicine Adam Wanner, MD Joseph Weintraub Chair in Pulmonary Diseases Professor of Medicine

Associate Professors of Clinical Medicine Michael A. Campos, MD Section Chief Pulmonary at the VA Elio Donna, MD Medical Director, Pulmonary Function Laboratory at UMHC-Sylvester Shirin Shafazand, MD Assistant Professors of Clinical Medicine Alexandre R. Abreu, MD Sleep Fellowship Program Director Director, UM Sleep Laboratory Co-Director, UHealth Sleep Center Luis M. Alvarez, MD Tanira D. Ferreira, MD Director, Clinical Services Director, ICU services UMH Lauren M. Fine, MD Viviana M. Temino, MD Assistant Professors of Medicine Gregory E. Holt, MD, PhD Andreas Schmid, MD Research Professor Philip L. Whitney, PhD Research Professor Emeritus Research Associate Professor Rosanna Forteza, MD Research Assistant Professor Eliana P. Mendes, MD

A UNIQUE ASSESSMENT OF CYSTIC FIBROSIS AND NON-CF BRONCHIECTASIS Patients who are coughing for years often suffer from bronchiectasis, a disease of dilated bronchi that is often misdiagnosed. The Division can be challenged by difficult to diagnose cases. Through clinical research and the use of the Division’s basic science laboratories, the faculty is able to analyze complex clinical cases, make comprehensive assessments and final diagnoses.

University of Miami Cystic Fibrosis Research Staff and Adult Program Investigators Left to Right: Patricia Graham, Mia Velasco, Dr. Eliana Mendes, Lilian Cadet, Dr. Matthias Salathe, Johana Arana (front), Dr. Andreas Schmid, Dr. Jaime Avecillas, and Carolina Aguiar.

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Division of Rheumatology and Immunology Rheumatology undergoes incredible growth in clinical research The Division of Rheumatology specializes in rheumatic diseases, nurtures study populations related to this area of focus, and provides cutting-edge world-class care.

Current clinical research projects complement ongoing basic and translational immunology research within the Division that is supported by multiple peer-reviewed federally funded grants.

We salute Duane R. Schultz, MD, our esteemed complement expert, who has been promoted to Professor Emeritus and continues to play a vigorous role in our immunology/basic science education activities. The Division also welcomes Schartess Culpepper-Pace, MD, to our faculty.

Schartess Culpepper-Pace, MD, is a clinical investigator with an interest in materno-fetal medicine in rheumatology. A Florida native who is a former Jackson/University of Miami trainee, Dr. CulpepperPace completed her rheumatology fellowship at Emory University, and joins UM after two years in private practice in Miami. She became interested in rheumatology early in her medical career due to the complexity of the conditions seen in patients as well as the emerging insights and treatment options developing in the area of inflammatory diseases. Although Dr. CulpepperPace takes an interest in all rheumatic/inflammatory conditions, her particular interest focuses on autoimmune processes in women. In addition to seeing patients at the main UM medical campus, Dr. Culpepper-Pace works at UM’s newest rheumatology satellite practice in Kendall.

The Division is also proud to announce that it experienced major growth in funded clinical research this past year.

Schartess Culpepper-Pace, MD

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EVIDENCE-BASED MEDICINE The Division of Rheumatology has become a leader in the Evidence-Based Medicine movement, bringing research insight into clinical practice. Larry Young, MD, Assistant Professor of Clinical Medicine, Chief of Rheumatology at the Miami VA, and Director of the Vasculitis Clinic, was recently promoted to co-director of the program on teaching evidence-based practice at an annual international conference held at Duke University. Dr. Young was also a named contributor to The Rational Clinical Examination Education Guides on JAMAevidence.com.

In this work, Dr. Young performs topic-based literature reviews and analysis to identify various approaches, supported by rigorous research evidence, of the diagnosis and treatment of rheumatic disease patients. He then educates trainees on how to read and interpret the evidence contained in research reports, as well as how to incorporate new insights from research trials into clinical practice.

Larry Young, MD, has been an Associate Director of the Internal Medicine training program for many years in addition to his rheumatology duties. As a trusted clinician to his patients, and a friend to scores of trainees, Dr. Young follows in the path of his mentor, Harvey E. Brown, Jr., MD, who passed away in 2012 at age 89 after 55 years on the faculty.

In memory of Dr. Brown, the first practicing rheumatologist at the University of Miami and Miami VA faculty, a fund has been established to support the ongoing commitment of the Division of Rheumatology to medical education.

Harvey E. Brown, Jr., MD

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RHEUMATOLOGY’S LEADERSHIP Chief of Rheumatology Eric L. Greidinger, MD, is an expert in mixed connective tissue disease and related rheumatic overlap syndromes. As Division Chief, Dr. Greidinger has pioneered the development of Rheumatology Intake Clinics to increase rheumatology services to new patients. These clinics leverage the worldrenowned expertise of the faculty, and have resulted in a quadrupling of funded research studies.

Dr. Greidinger is a member of the Cancer Center at UM and serves on the Research and Development and Scientific Review Committees at the Miami VA Medical Center. He also lends his expertise to numerous scientific review panels, including those for the NIH, VA, Arthritis Foundation and Lupus Research Institute.

MUSCULOSKELETAL ULTRASOUND SERVICES AVAILABLE AT THREE SITES Musculoskeletal ultrasound machines, which help guide injections and establish specific diagnoses, are present at three of the Division’s clinical sites: Deerfield Beach, Plantation and the UM Medical Campus.

Trained rheumatology faculty use these machines to provide important training and help the Division’s fellows learn the relevant musculoskeletal anatomy, as well as to familiarize students with the knowledge and clinical skills needed to work with emerging technologies.

By adding musculoskeletal ultrasound services, and planning for further expansion throughout various campuses, the rheumatology Division proves its ongoing commitment to maintaining excellence and leadership in the field.

DIVISION FACULTY LIST Eric L. Greidinger, MD Division Chief Associate Professor of Medicine

Professor of Clinical Medicine Carlos J. Lozada, MD Fellowship Program Director Associate Professor of Medicine Dana Ascherman, MD

Assistant Professors of Clinical Medicine Maria F. Carpintero, MD Schartess Culpepper-Pace, MD Ozlem Pala, MD Christine Savage, MD Elaine C. Tozman, MD Larry Young, MD Chief of Rheumatology, Miami VA

THE CONNECTION BETWEEN LUNG DISEASE AND RHEUMATOID ARTHRITIS Dana Ascherman, MD, Associate Professor of Medicine, and his collaborators have revolutionized the understanding of lung disease in rheumatoid arthritis.

After first writing the Roadmap to Promote Clinical and Translational Research in Rheumatoid ArthritisAssociated Interstitial Lung Disease, Dr. Ascherman and his colleagues combined basic science techniques with patient-based studies to identify novel targets of autoimmunity specific for rheumatoid lung disease.

This work holds great promise to identify patients at risk for lung complications in rheumatoid arthritis, and may lead to new treatments for this condition. Dr. Ascherman’s research is providing important insight into the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF), a common, and potentially deadly, lung condition.

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Artist House Weekly farmers’ market in Alacati, on the western coast of Turkey

by Erin N. Marcus, MD, MPH, FACP Associate Professor of Clinical Medicine, Division of General Internal Medicine

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High Impact Publications Department of Medicine faculty are extremely productive, publishing over 1,000 original articles in a number of outstanding internal medicine and subspecialty journals. Below is a sampling of some recent high-impact papers.

CARDIOVASCULAR Cohen MG, Singh V, Martinez CA, O’Neill BP, Alfonso CE, Martinezclark PO, Heldman AW, O’Neill WW. Transseptal antegrade transcatheter aortic valve replacement for patients with no other access approach – A contemporary experience.

Catheter Cardiovasc Interv 2013;82:987–993 Deshmukh A, Patel NJ, Pant S, Shah N, Chothani A, Mehta K, Grover P, Singh V, Vallurupalli S, Savani GT, Badheka A, Tuliani T, Dabhadkar K, Dibu G, Reddy YM, Sewani A, Kowalski M, Mitrani R, Paydak H, Viles-Gonzalez JF. In-hospital complications associated with catheter ablation of atrial fibrillation in the United States between 2000 and 2010: analysis of 93 801 procedures. Circulation. 2013;128:2104-12.

Heldman AW, DiFede DL, Fishman JE, Zambrano JP, Trachtenberg BH, Karantalis V, Mushtaq M, Williams AR, Suncion VY, McNiece IK, Ghersin E, Soto V, Lopera G, Miki R, Willens H, Hendel R, Mitrani R, Pattany P, Feigenbaum G, Oskouei B, Byrnes J, Lowery MH, Sierra J, Pujol MV, Delgado C, Gonzalez PJ, Rodriguez JE, Bagno LL, Rouy D, Altman P, Foo CW, da Silva J, Anderson E, Schwarz R, Mendizabal A, Hare JM. Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial.

JAMA 2014; 311: 62-73.

Hendel RC, Bozhurt B, Fonaroa GC, Jacobs JP, Lichtman JH, Smith EE, et al. ACC/AHA 2013 Methodology for developing clinical data standards: a report of the American College of Cardiology/ American Heart Association Task Force on Clinical Data Standards. J Am Coll Cardiology 2014; 63: 2323-34.

Myerburg RJ, Halperin H, Egan D, Boineau R, Chugh SS, Gillis AM, Goldhaber J, Lathrop DA, Liu P, Niemann JT, Ornato JP, Sopko G, Van Eyk J, Walcott G, Weisfeldt M, Wright JD, Zipes DP: Pulseless electrical activity – definition, causes, mechanisms, management, and research priorities for the next decade: Report from a National Heart, Lung, and Blood Institute Workshop.

Circulation 2013; 128:2532-2541.

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Alfonso CE, Mitrani RD, Macon C, Carrillo RG, Williams DB, O’Neill WW, Myerburg RJ. Newonset atrial fibrillation after aortic valve replacement: comparison of transfemoral, transapical, transaortic and surgical approaches. J Am Coll Cardiol 2014;63:1510-1519.

CLINICAL PHARMACOLOGY Preston, RA, Afshartous D, Materson BJ, Alonso AB, Rodco R. Effects of Nebivolol versus Metoprolol on Sodium Sensitivity of Blood Pressure in Hispanic Postmenopausal Women with Hypertension. Hypertension 2014;64: 287-295.

Preston RA, Kareem A, Dudkowkski C, Zhao Z, Garg D, Lenz O, Sica D. Single-Center Evaluation of the Single-Dose Pharmacokinetics of the Angiotensin II Receptor Antagonist Azilsartan Medoxomil in Renal Impairment. Clinical Pharmacokinetics 2013;52:347-358.

Preston RA, Afshartous DA, Forte L, Rodco R, Alonso AB, Garg D, Raij L. Sodium challenge does not support an acute gastrointestinal-renal natriuretic signaling axis in humans. Kidney International 2012; 82:1313-1320.

Preston RA, Afshartous D, Garg D, Medrano S, Alonso AB, Rodriguez R. Mechanisms of impaired potassium handling with dual renin-angiotensinaldosterone blockade in chronic kidney disease.

Hypertension 2009; 53:754-760.

Preston RA, Afshartous D, Alonso AB Effects of selective versus nonselective cyclooxygenase inhibition on dynamic renal potassium excretion: a randomized trial. Clinical Pharmacology and Therapeutics 2008;84:208-211.

El-Maouche D, Collier S, Prasad M, Reynolds JC, Merke DP. Bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Clin Endocrinol (Oxf).

2014 May 24.

Golden S, Kim C, Barrett-Connor E, Nan B, Kong S, Goldberg R and the Diabetes Prevention Program Research Group. The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program.

Metabolism Clinical and Experimental 62 (2013) 1313-1322.

Kargi A.Y., Merriam G.R. Diagnosis and treatment of growth hormone deficiency in adults. Nature Reviews Endocrinology. 30 April 2013.

Lagari VS, Gómez-Marín O, Levis S. Study design and baseline characteristics of participants in the Vitamin D in Vulnerable Adults at the VA (the VIVA Study). Contemp Clin Trials. 2014 Aug 2;39(1):66-73. doi: 10.1016/j. cct.2014.07.009.

Lagari V, Gómez-Marín O, Levis S. The role of vitamin D in improving physical performance in the elderly. J Bone Miner Res 28:2194-2201, 2013.

Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett D, Wilson DM, Skyler JS, and the Type 1 Diabetes TrialNet Canakinumab Study

Rahman M, Ford CE, Cutler JA, Davis BR, Pillar LB, Whelton PK, Wright Jr JT, Barzilay JI, Brown CD, Colon Sr PJ, Fine LJ, Grimm Jr RH, Gupta AK, Baimbridge C, Haywood LJ, Henriquez EI, Oparil S, Preston RA. Long-term renal and cardiovascular outcomes in Antihypertensive and LipidLowering Treatment to Prevent Heart Attack Trial (ALLHAT) Participants by baseline estimated GFR. Clin J Am Soc Nephrol 2012;7:989-1002.

ENDOCRINOLOGY, DIABETES, AND METABOLISM Ayala AR, Manzano A. Detection of recurrent Cushing’s disease: proposal for standardized patient monitoring following transsphenoidal surgery. Neurooncol. 2014; 119(2): 235–242.

Dang S, Levis S, Lagari VS. If you take it, it works. J Womens Health 23:278, 2014.

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Group; and Pickersgill L, de Koning E, Ziegler A-G, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castaño L, Wägner A, Lervang HH, Perrild H, MandrupPoulsen T, on behalf of the AIDA Study Group.

Interleukin-1 Antagonism in Type 1 Diabetes of Recent Onset: Two Multicenter, Randomized Double-Masked, Placebo-Controlled Trials. Lancet 2013; 381:1905-1915.

Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Peakman M, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Skyler JS, and and The Type 1 Diabetes TrialNet Abatacept Study Group.

Co-Stimulation Modulation with Abatacept in Patients with Recent-Onset Type 1 Diabetes: Follow-Up One Year After Cessation of Treatment.

Diabetes Care 2014; 37:1069-1075.

Sosenko JM, Skyler JS, Palmer JP, Krischer, JP, Yu L, Mahon J, Beam CA, Boulware DC, Rafkin L, Schatz, D; Eisenbarth, G, The Type 1 Diabetes TrialNet and the Diabetes Prevention Trial-Type 1 Study Groups. The prediction of Type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetes patients. Diabetes Care 2013 36:2615-2620.

Almaca, J., Molina,J. Arrojo E Drigo, R., Abdulreda, MH, Jeon, WB, Berggren, PO, Caicedo, A., and HG Nam. 2014. Young capillary vessels rejuvenate aged pancreaetic islets. Proc Natl Acad Sci USA 111:1762-7, 2014.

GASTROENTEROLOGY Barboza JL, Talley NJ, Moshiree B. Current and Emerging Pharmacotherapeutic Options for Irritable Bowel Syndrome. Drugs. 2014 Sep 27.

[Epub ahead of print] Damas OM, Jahann DA, Reznik R, McCauley JL, Tamariz L, Deshpande AR, Abreu MT, Sussman DA. Phenotypic manifestations of inflammatory bowel disease differ between Hispanics and non-Hispanic whites: results of a large cohort study. Am J Gastroenterol.

2013;108(2):231-9.

Panara AJ, Yarur AJ, Rieders B, Proksell S, Deshpande AR, Abreu MT, Sussman DA. The incidence and risk factors for developing depression after being diagnosed with inflammatory bowel disease: a cohort study. Aliment Pharmacol Ther.

2014;39(8):802-10.

Ramesh R, Kozhaya L, McKevitt K, Djuretic IM, Carlson TJ, Quintero MA, McCauley JL, Abreu MT, Unutmaz D, Sundrud MS. Pro-inflammatory human Th17 cell selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med. 2014 13;211(1):89-104.

Raskin JB, Kamm MA, Jamal MM, Márquez J, Melzer E, Schoen RE, Szalóki T, Barrett K, Streck P. Mesalamine did not prevent recurrent diverticulitis in phase 3 controlled trials. Gastroenterology. 2014;147(4):793-802.

Santaolalla R, Sussman DA, Ruiz JR, Davies JM, Pastorini C, España CL, Sotolongo J, Burlingame O, Bejarano PA, Philip S, Ahmed MM, Ko J, Dirisina R, Barrett TA, Shang L, Lira SA, Fukata M, Abreu MT. TLR4 activates the-catenin pathway to cause intestinal neoplasia. PLoS One 2013, 14;8(5):e63298.

Sussman DA, Santaolalla R, Bejarano PA, Garcia-Buitrago MT, Perez MT, Abreu MT, Clarke J. In silico and Ex vivo Approaches Identify a Role for Toll-Like Receptor 4 in Colorectal Cancer.

Journal of Experimental & Clinical Cancer Research. 33(1):45, 2014.

Yarur AJ, Abreu MT, Salem MS, Deshpande AR, Sussman DA. The impact of race and Hispanic ethnicity on post-surgical complications in patients with inflammatory bowel disease. Dig Dis Sci 2014;59(1):126-34.

Lily pond at Fairchild Tropical Botanic Garden in Miami by Marc Lippman, MD, MACP, FRCP, Leonard M. Miller Professor of Internal Medicine, Psychiatry and Behavioral Sciences and Deputy Director, Sylvester Comprehensive Cancer Center,

Yarur AJ, Mandalia AB, Dauer RM, Czul F, Deshpande AR, Kerman DH, Abreu MT, Sussman DA. Predictive factors for clinically actionable computed tomography findings in inflammatory bowel disease patients seen in the emergency department with acute gastrointestinal symptoms. J Crohns Colitis 2014;8(6):504-12.

GENERAL INTERNAL MEDICINE Amber KT, Dhiman G, Goodman KW. Conflict of interest in online point-of-care clinical support websites. Journal of Medical Ethics. 2014 Feb 3. doi: 10.1136/medethics-2013-101625. PMID: 24493079.

Kenya S, Jones J, Arheart K, Chida N, Baer R, Powell A, Symes S, Hunte T, Monroe A, Kobetz E. Carrasquillo O. Using Community Health Workers to Improve Clinical Outcomes among People Living with HIV: A Randomized Controlled Trial.

AIDS Behav. 2013 Nov;17(9):2927-34.

Palacio AM, Campbell D, Moore M, Symes S, Tamariz L. Predictors of scholarly success among internal medicine residents. Am J Med. 2013 Feb;126(2):181-5.

Tamariz L, Hernandez F, Bush A, Palacio A, Hare JM. Association between serum uric acid and atrial fibrillation: a systematic review and metaanalysis. Heart Rhythm. 2014 Jul;11(7):1102-8. doi: 10.1016/j.hrthm.2014.04.003. Epub 2014 Apr 5. PubMed PMID: 24709288.

GERIATRICS AND PALLIATIVE MEDICINE Andrade AD, Anam R, Sun H, Mintzer MJ, Ruiz JG. Effects on performance of individual versus dyadic practice during an avatar-based threedimensional virtual home safety simulation. Stud Health Technol Inform 184:13-19, 2013.

Curtis KM, Aenlle KK, Roos BA, Howard GA. 24R,25-dihydroxyvitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells. Mol Endocrinol 28:644-658, 2014.

Florez H, Temprosa MG, Orchard TJ, Mather KJ, et al., for the Diabetes Prevention Program Research Group. Metabolic syndrome components and their response to lifestyle and metformin interventions are associated with differences in diabetes risk in persons with impaired glucose tolerance. Diabetes Obes Metab 16:326-33, 2014.

Lagari VS, Levis S. Phytoestrogens in the prevention of postmenopausal bone loss. J Clin Densitom 16:445-9, 2013.

University of Miami Miller School of Medicine

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High Impact Publications HEMATOLOGY-ONCOLOGY Akbari M, Donenberg T, Lunn J, Curling D, Turnquest T, Krill-Jackson E, Zhang S, Narod S, Hurley J. The spectrum of BRCA1 and BRCA2 mutations in breast cancer patients in the Bahamas. J Clin Genet. 2014 Jan:85(1):64-7. doi: 10.1111/ cge.12132. Epub 2013 Apr. Bhatt S, Ashlock BM, Toomey NL, Diaz LA, Mesri EA, Lossos IS, Ramos JC. Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. J Clin Invest. 2013 May 1.

Drews-Elger K, Iorns E, Dias A, Ward TM, Dean SJ, Clarke J, Miller P, Campion-Flora A, NavaRodrigues D, Reis-Filho JS, Rae JM, Thomas, D, Berry D, El-Ashry D, and Lippman ME. Infiltrating S100A8+ Myeloid Cells Promote Metastatic Spread of Human Breast Cancer Growth and Predict Poor Patient Outcome. Breast Cancer Res Treat, 2014 Nov;148(1):41-59.

Gjolaj L, Gari G, Olier-Pino, A, Garcia J, Fernandez G. Decreasing Laboratory Turnaround Time and Patient Wait Time by Implementing Process Improvement Methodologies in an Outpatient Oncology Infusion Unit. Journal of Oncology Practice (JOP), 2014 Oct 21. Pii: JOP.2014.001499.

Long, Y, Tsai W-B, Wangpaichitr M, Tsukamoto T, Savaraj N, Feun LG, Kuo M-T Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence and glutamine addiction Mol Cancer Ther November 2013 12:2581-2590.

Romero-Camarero I, Jiang X, Natkunam Y, Lu X, Vicente-Dueñas C, Gonzalez-Herrero I, Flores T, Garcia JL, McNamara G, Kunder C, Zhao S, Segura V, Fontan L, Martínez-Climent JA, García-Criado FJ, Theis JD, Dogan A, CamposSánchez E, Green MR, Alizadeh AA, Cobaleda C, Sánchez-García I, Lossos IS. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation. Nat Commun. 2013;4:1338. doi: 10.1038/ ncomms2334.

Shindo T, Kim TK, Benjamin CL, Wieder ED, Levy RB, Komanduri KV. MEK inhibitors selectively suppress alloreactivity and graft-versus-host disease in a memory stage-dependent manner. Blood 2013 Jun 6;121(23):4617-26. doi: 10.1182/blood-2012-12-476218. Epub 2013 Apr 10. PMID: 23575444 [PubMed - indexed for MEDLINE]. PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.

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HEPATOLOGY

Lenchus JD, Carvalho CM, Ferreri K, Sanko JS, Arheart KL, Fitzpatrick M, Issenberg SB. Filling the void: defining invasive bedside procedural competency for internal medicine residents.

J Grad Med Educ. 2013 Dec;5(4):605-12. doi: 10.4300/JGME-D-13-00030.

Afdhal N, Reddy KR, Nelson DR, Lawitz E, Gordon SC, Schiff ER, Nahass R, et al. Ledipasvir and sofosbuvir for previously treated genotype I infection. N Engl J Med. 2014;370:1483-93.

Lizarraga KJ, Florindez JA, Daftarian P, Andrews DM, Ortega LM, Mendoza JM, Contreras GN, Nayer A. Anti-GBM disease and ANCA during dengue infection. Clin Nephrol. 2014 Apr 2.

Bhamidimarri KR, Beduschi T, Vianna R. Multivisceral transplant: where do we stand? Clin Liver Dis 2014;18:661-74.

Mushtaq M, Cohn SL. Perioperative beta-blockers in noncardiac surgery: the evidence continues to evolve. Cleve Clin J Med. 2014 Aug;81(8):50112. doi: 10.3949/ccjm.81a.14015.

Vu LP, Perna F, Wang L, Voza F, Figueroa ME, Tempst P, Erdjument-Bromage H, Gao R, Chen S, Paietta E, Deblasio T, Melnick A, Liu Y, Zhao X, Nimer SD. Cell Rep. 2013 Dec 26;5(6):1625-38.

Czul F, Peyton A, Levy C. Primary biliary cirrhosis: therapeutic advance. Clin Liver Dis 2013;17:229-41.

Hernandez MD, Sherman KE. HIV/hepatitis C co-infection: natural history and disease progression. Curr Opin HIV AIDS 2011;6:478-83.

Jeffers L et. al Antiviral efficacy of entecavir in nucleos(t)ide-naïve patients of Black/African descent with chronic hepatitis B. J Viral Hep 2014;21:74-6.

Levy C, Naik J, Giordano C, Mandalia A, O’Brien C, Bhamidimarri KR, Schiff ER, Martin P. Hispanics with PBC are more likely to have features of autoimmune hepatitis and reduced response to ursodeoxycholic acid than non-Hispanics. Clin Gastroenterol Hepatol. 2014:12:1398-405.

Martin P, DiMartini A, Feng, S, Brown R, Fallon M. Evaluation for liver transplantation in adults:2013 guidelines of the American Association for the Study of Liver Diseases and the American Society of Transplant. Hepatology 2014;59:1144-65.

Woo GA, O’Brien C. Longterm management of alcoholic liver disease. Clin Liver Dis 2012;16:179-92.

HOSPITAL MEDICINE Eymin G, Aizman A, Lopetegui M, Manjarrez E. The discharge process. Rev Med Chil.

2014 Feb;142(2):229-37. doi: 10.4067/S003498872014000200012. Spanish.

Eymin G, Zuleta J. Hospital case management.

Rev Med Chil. 2013 Nov;141(11):1434-40. doi: 10.4067/S0034-98872013001100010. Spanish.

INFECTIOUS DISEASES Abbo LM, Cosgrove SE, Pottinger PS, Pereyra M, Sinkowitz-Cochran R, Srinivasan A, Webb DJ, Hooton TM. Medical students’ perceptions and knowledge about antimicrobial stewardship: How are we educating our future prescribers? Clin Infect Dis. 2013 Sep;57(5):631-8. doi: 10.1093/cid/cit370. Epub 2013 May 31. PubMed PMID: 23728148.

Alcaide ML, Parmigiani A, Pallikkuth S, Roach M, Freguja R, Della Negra M, Bolivar H, Fischl MA, Pahwa S. Immune activation in HIV-infected aging women on antiretrovirals--implications for age-associated comorbidities: a cross-sectional pilot study. PLoS One. 2013 May 28;8(5):e63804. doi: 10.1371/journal.pone.0063804. Print 2013.

PubMed PMID: 23724003; PubMed Central MCID: PMC3665816.

Campo R, DeJesus E, Bredeek UF, Henry K, Khanlou H, Logue K, Brinson C, Benson P, Dau L, Wang H, White K, Flaherty J, Fralich T, Guyer B, Piontkowsky D. SWIFT: Prospective 48-week study to evaluate efficacy and safety of switching to emtricitabine/tenofovir from lamivudine/abacavir in virologically suppressed HIV-1 infected patients on a boosted protease inhibitor containing antiretroviral regimen. Clin Infect Dis. 2013 Jun;56(11):1637-45. doi: 10.1093/cid/cis1203.

Epub 2013 Jan 29. Erratum in: Clin Infect Dis. 2013 Sep;57(5):779. PubMed PMID: 23362296; PubMed Central PMCID: PMC3641864.

Ferrada MA, Quartin AA, Kett DH, Morris MI. Candidemia in the critically ill: initial therapy and outcome in mechanically ventilated patients. BMC Anesthesiol. 2013 Oct 30;13(1):37. doi: 10.1186/1471-2253-13-37. PubMed PMID: 24172136; PubMed Central PMCID: PMC3827504.

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Fletcher, C, Staskus, K, Wietgrefe, S, Rothenberger, M, Reilly, C, Chipman, J, Beilman, G, Khoruts, A, Thorkelson, A, Schmidt, T, Anderson, J, Perkey, K, Stevenson, M, Perelson, A, Douek, D, Haase, A, Schacker, T, Persistent HIV-1 Replication is Associated with Lower Antiretroviral Drug Concentrations in Lymphatic Tissues. Proc. Natl.

Acad Sci USA. 2014 Feb 11;111(6):2307-12. doi: 10.1073/pnas.1318249111. Epub 2014 Jan 27. PubMed PMID: 24469825; PubMed Central PMCID: PMC3926074.

Hooton TM, Roberts PL, Cox ME, Stapleton AE. Voided midstream urine culture and acute cystitis in premenopausal women. N Engl J Med. 2013 Nov 14;369(20):1883-91. doi: 10.1056/ NEJMoa1302186. PubMed PMID: 24224622; PubMed Central PMCID: PMC4041367.

NEPHROLOGY AND HYPERTENSION Cyclodextrin protects podocytes in diabetic kidney disease. Merscher-Gomez S, Guzman J, Pedigo CE, Lehto M, Aguillon-Prada R, Mendez A, Lassenius MI, Forsblom C, Yoo T, Villarreal R, Maiguel D, Johnson K, Goldberg R, Nair V, Randolph A, Kretzler M, Nelson RG, Burke GW 3rd, Groop PH, Fornoni A; FinnDiane Study Group Diabetes. Diabetes. 2013 Nov;62(11):3817-27.

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease. Yoo TH, Pedigo CE, Guzman J, Correa-Medina M, Wei C, Villarreal R, Mitrofanova A, Leclercq F, Faul C, Li J, Kretzler M, Nelson RG, Lehto M, Forsblom C, Groop PH, Reiser J, Burke GW, Fornoni A, Merscher S. Journal of the American Society of Nephrology. 2014 Jun 12. pii: ASN.2013111213.

[Epub ahead of print] Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW 3rd, Abel ED, Brosius FC, Fornoni A. Diabetes. 2014 Feb;63(2):701-14 Kidney allograft survival of African American and Caucasian American recipients with lupus.

Contreras G, Li H, Gonzalez-Suarez M, Isakova T, Scialla JJ, Pedraza F, Mattiazzi A, Diaz-Wong R, Sageshima J, Brito Y, Guerra G, Acevedo B, Sajid Ali A, Kershaw TJ, Chen L, Burke GW, Kupin W, Ciancio G, Roth D. Lupus. 2014 Feb;23(2):151-8.

In vivo imaging of kidney glomeruli transplanted into the anterior chamber of the mouse eye.

Kistler AD, Caicedo A, Abdulreda MH, Faul C, Kerjaschki D, Berggren PO, Reiser J, Fornoni A. Scientific Reports. 2014 Jan 27;4:3872.

Abatacept in B7-1-positive proteinuric kidney disease. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P. New England Journal of Medicine. 2013 Dec 19;369(25):2416-23.

PULMONARY, ALLERGY, CRITICAL CARE AND SLEEP Campos M, Kueppers F, Stocks J, Strange C, Chen J, Griffin R, Wang-Smith L, Brantly M. Safety and pharmacokinetics of 120 mg/kg versus 60 mg/kg weekly intravenous infusions of alpha-1 proteinase inhibitor in alpha-1 antitrypsin deficiency: a multicenter, randomized, doubleblind, crossover study (Spark). COPD. 2013 10(6): 687-95.

Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014 Mar 1;145(3):454-63. doi: 10.1378/chest.13-2408.

Geraghty P, Eden E, Pillai M, Campos M, McElvaney NG, Foronjy RF. -1 Antitrypsin activates protein phosphatase 2A (PP2A) to counter lung inflammatory responses. Am J Respir Crit Care Med. 2014 Oct 23. [Epub ahead of print] King TE Jr, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L, Lederer DJ, Nathan SD, Pereira CA, Sahn SA, Sussman R, Swigris JJ, Noble PW. ASCEND study group.A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014 May 29;370(22):2083-92. doi: 10.1056/ NEJMoa1402582. Epub 2014 May 18. Erratum in: N Engl J Med. 2014 Sep 18;371(12):1172.

Quittner A, O’Donnell A, Salathe MA, Lewis S, McKevitt M, Li X, Montgomery AB, O’Riordan T, Barker A. Quality of life questionnaire-bronchiectasis: Final psychometric analyses and determination of minimal important difference scores.

Thorax 2014: in press.

Quittner A, Marciel K, Salathe MA, O’Donnell A, Gotfried M, Ilowite J, Metersky M, Flume P, Lewis S, McKevitt M, Montgomery AB, O’Riordan T, Barker A. A preliminary quality of life questionnaire-bronchiectasis: a patient-reported outcome measure for bronchiectasis. Chest 2014; 146: 437-48.

Schmid A, Meili D, Salathe MA. Soluble adenylyl cyclase in health and disease. Biochim.

Biophys. Acta – Molecular Basis of Disease.

2014: in press.

Unwalla H, Ivonnet P, Dennis JS, Conner GE, Salathe MA. TGF-β1 and cigarette smoke inhibit the ability of β2-agonists to enhance epithelial permeability. Am. J. Respir. Cell Mol. Biol 2014: in press.

RHEUMATOLOGY AND IMMUNOLOGY American College of Rheumatology Committee on Rheumatology Training and Workforce Issues, FitzGerald JD, Battistone M, Brown CR Jr, Cannella AC, Chakravarty E, Gelber AC, Lozada CJ, Punaro M, Slusher B, Abelson A, Elashoff DA, Benford L. Regional distribution of adult rheumatologists. Arthritis Rheum. 2013 Dec;65(12):3017-25.

Harlow L, Rosas IO, Gochuico BR, Michaels TR, Dellaripa P, Oddis CV, and Ascherman DP. Identification of Citrullinated Heat Shock Protein 90 Isoforms as Novel Autoantigens in Rheumatoid Arthritis-associated Interstitial Lung Disease.

Arthritis and Rheum. 65: 869-879, 2013.

Zang Y, Martinez L, Fernandez I, Pignac-Kobinger J, Greidinger EL. Conservation of Pathogenic TCR Homology across Class II Restrictions in Anti-Ribonucleoprotein Autoimmunity: Extended Efficacy of T Cell Vaccine Therapy. J Immunol.

192(9):4093-102, 2014.

Lockett A, Brown MB, Santos-Falcon N, Rush NI, Oueni H, Oberle AJ, Bolanis E, Fragoso MA, Petrusca DN, Serban KA, Schweitzr KS, Presson RG, Campos M*, Petrache I*. Active trafficking of alpha-1 antitrypsin across the lung endothelium. PLoS one. 2014 Apr 17;9(4):e93979 *equal contributors as senior authors.

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Leadership The art of transformational leadership is at the center of great institutions. These are enabled to become great by the relentless work of innovative leaders.

President Donna Shalala and Dean and Executive Vice President for Health Affairs Pascal Goldschmidt guide the University of Miami and the Miller School of Medicine into the future with visionary leadership.

These executives also set the tone for the Department of Medicine, its thirteen divisions and 350 faculty, as well as its 382 residents and fellows. As leaders of the Miller School of Medicine, they positively transform lives through education, discovery and service to our community, our country and throughout the world.

The Department of Medicine is proud they are our partners and extremely grateful for their leadership.

President Donna Shalala

Dean Pascal Goldschmidt

Visionaries in transformation

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Philanthropy Philanthropic generosity has a profound impact on the Department of Medicine. Each year, hundreds of donors bestow gifts of all sizes to the University, supporting our mission and helping us advance medical science, develop new treatments and cures, train new generations of physicianscientists and improve the health of those in Miami, South Florida and beyond.

The following pages include highlights of our donors’ generosity as well as a few stories about those who have made a difference to the Department of Medicine with their gift. We are very grateful for our donors’ leadership giving and their unwavering dedication and support of our work.

Beverly J. Harrington, CFRE Senior Development Director Department of Medicine

From left to right, back row: Bill Harris, Mrs. Elaine Sussman, Andrea Sussman, President Donna Shalala, Dean Pascal Goldschmidt Front row: Sydney Sussman, Dr. Alan Heldman and Addie Heldman

in the

Artist House

ELAINE AND SYDNEY SUSSMAN ENDOWED CHAIR IN INTERVENTIONAL CARDIOLOGY PRESENTED TO DR. ALAN W. HELDMAN Longtime philanthropists Sydney and Elaine Sussman made their most recent gift hoping that it will improve the care of cardiovascular patients for generations to come. The Sussmans presented the Elaine and Sydney Sussman Endowed Chair in Interventional Cardiology to its first recipient, Alan W. Heldman, MD, Director of Interventional Cardiology, during a dedication ceremony October 7 on the medical school campus.

The Sussmans have made an enduring impact on the University of Miami Miller School of Medicine. They became ardent supporters of University of Miami Hospital (UMH) heart services, making a significant gift for equipment and space renovations, and ultimately became principal donors, naming the Elaine and Sydney Sussman Cardiac Catheterization Laboratories in 2011.

Thanks to their generosity, UMH has a state-of-the-art facility where interventional cardiologists, heart surgeons, and nurses work as a team to diagnose problems and perform lifesaving procedures ranging from angioplasty to aortic valve replacement. The lab also contains advanced imaging equipment and robotic technology for superb accuracy.

In 2013, the Sussmans donated additional catheterization laboratory equipment, and pledged support to help build the University of Miami’s Crohn’s and Colitis Center, which now provides world-class care for those living with inflammatory bowel disease (IBD).

Through interdisciplinary clinical care and laboratory research into Crohn’s disease and colitis, the Elaine and Sydney Sussman Family Crohn’s and Colitis Clinic at the University of Miami Hospital and Clinics provides a medical home for patients with chronic digestive disorders.

Dr. Heldman said the Sussmans’ transformative gifts not only help him and his staff deliver exceptional care to patients, but save lives every day. Humbled by their generosity, Dr. Heldman looks forward to bringing new and innovative cardiovascular concepts to fruition.

Grant Park, Chicago October 2014 by David Lang, MD, Emergency Medicine Physician at UMH.

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Philanthropy COLDWELL BANKER ‘CARES’ FOUNDATION SUPPORTS SUSSMAN FAMILY CROHN’S AND COLITIS CLINIC In order to help improve care and raise awareness about Crohn’s disease and ulcerative colitis, the Coldwell Banker Residential Real Estate CARES Foundation made a generous donation to name one of the clinic’s four state-of-the-art infusion suites. As one of the CARES foundation’s largest single gifts of the year, representatives visited the clinic June 12 to present a ceremonial check for $25,000 to Director Maria T. Abreu, MD. Supporting this effort was Coldwell Banker Senior Vice President and General Counsel Mitchell Cook.

DR. ALESSIA FORNONI HONORED WITH THE PEGGY AND HAROLD KATZ FAMILY CHAIR From left, back row, Dr. Roy Weiss, Jacquelyn Katz, Peggy Katz, Dr. Oliver Lenz, Dr. Pascal J. Goldschmidt, Dr. David Roth, Front row: Dr. Alessia Fornoni, center, with children Paolo, 5, and Martina, 8.

LIPSON FAMILY GIFT SUPPORTS KIDNEY REPAIR AND ENDOWED LECTURE SERIES Arthur E. Lipson*, a well-respected CPA in South Florida for over 50 years, and his wife, Rochelle “Shelly” provided a generous donation to the University of Miami’s Miller School of Medicine shortly before his passing in January 2014.

The Lipsons’ $250,000 gift primarily benefitted the Interdisciplinary Stem Cell Institute at the Miller School while a separate portion of the gift established the Lipson Endowed Speaker Series, which began in September.

Arthur Lipson, a 1962 graduate of UM’s School of Business Administration, had been a longtime patient of Joshua Hare, MD, founding director of the Interdisciplinary Stem Cell Institute and a Louis Lemberg Professor of Medicine. The majority of the Lipson family donation will be used to help develop stem cell therapy for the repair of kidney damage.

Shelly Lipson said Dr. Hare oversaw many aspects of Arthur’s care for years, which included battles with cancer, heart and kidney disease. “He was absolutely fantastic. I can’t say anything more. He was just a comforting, optimistic, wonderful doctor and he kept Arthur alive for a couple of extra years,” she said.

The Lipsons’ legacy at the Miller School of Medicine will live on in other ways, too. In May, Arthur’s greatnephew, Philip, and Philip’s first cousin, Paul, became the third generation of graduates of the Miller School of Medicine. Both of their fathers, and an uncle, are also Miller School alumni. Their grandfather also taught and practiced at UM’s Bascom Palmer Eye Institute for more than 30 years.

Arthur* and Shelly Lipson

*Deceased

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The Department of Medicine at the University of Miami Miller School of Medicine extends its deepest thanks to our many loyal supporters. Your gifts, listed below, support more than 370 physicians with appointments in the Department of Medicine and are represented by the 13 Divisions in this report.

The following listing recognizes individuals, associations, corporations, and foundations that donated or committed $50,000 or more to the Department of Medicine between January 1, 2013 and November 1, 2014.

By investing in the future of the Department of Medicine, these dedicated and visionary individuals help us to be the truly transformative organization we are today.

Department of Medicine Endowed Chairs and Professorships

$1 Million +

Lymphoma Research Foundation

American Heart Association

South Florida Veteran’s Affairs Foundation for Research & Education

Micky and Madeleine Arison Family Charitable Trust Sydney D. and Elaine Sussman Dohn and Joanne Trempala $250,000-$999,999 Anonymous (2) Certified Steel Company Wallace H. Coulter Foundation Crohn’s & Colitis Foundation of America

Woman’s Cancer Association of the University of Miami $50,000-$99,999 Audrey Love* American Society of Hematology Gertrude A. Barnett Foundation Jeffrey S. ’81 and Tracy Brown C & C BioPharma, LLC Brand Institute

Florida Cystic Fibrosis, Inc.

Chronic Fatigue Initiative

Flight Attendant Medical Research Institute

Dreama Foundation

Susan G. Komen for the Cure

The Dwoskin Charitable Trust Foundation

State of Florida

The Ford Foundation

Terry and Cynthia Taylor

Hernan R. Franco

The Breast Cancer Research Foundation

Mark and Elyse Gainor

Lester H. and Sue A. Smith

Burton* and Lydia Harrison

$100,000-$249,999

Ruben F. and Denise E. Lujo

American Cancer Society, Inc.

Robert and Lorraine McCashin

American Lung Association

Robert J. W. Moran

American Society of Nephrology

Palm Healthcare Foundation, Inc.

Florida Breast Cancer Coalition Research Foundation

Project Medishare for Haiti, Inc.

Florida Heart Research Institute

Research Triangle Institute

Stanley J. Glaser Foundation

Scleroderma Society, Inc.

Courtelis Distinguished Chair in Medical Oncology Pasquale W. Benedetto, M.D.

Keymorada Invitational Fly Spin Tournament

Benjamin Torchinsky*

Walter G. Ross Chair in Vascular Biology Keith Webster, Ph.D.

Steven and Ellen Shapiro

Translational Genomics Research Institute

Glenn and Ellen Widom

Translational Research in Oncology

Peggy & Harold Katz Family Chair for Kidney and Vascular Disease Research Alessia Fornoni, M.D., Ph.D.

Mitchell and Alicia Widom

Stuart R. Weiss, M.D. ‘71

American Heart Association Chair in Cardiovascular Research

Robert J. Myerburg, M.D. Louis Lemberg, M.D. Chair in Cardiology

Joshua M. Hare, M.D. Martin H. Kalser, M.D. Chair in Gastroenterology

Maria T. Abreu, M.D. Sol Cye Mandel Chair in Gastroenterology Jeffrey B. Raskin, M.D. William J. Harrington, M.D. Chair in Hematology/Oncology Joseph D. Rosenblatt, M.D. William Way Anderson, M.D. Chair in Nephrology David Roth, M.D. Joseph Weintraub Family Foundation Chair in Pulmonary Diseases Adam Wanner, M.D. Mary Jane Sertel Professorship in Pulmonary Diseases Matthias Salathe, M.D.

Elaine & Sydney Sussman Chair in Interventional Cardiology Alan W. Heldman, M.D.

Stephen and Lisa Harbin

Quantum Foundation, Inc.

*Deceased

Thank you!

Gifts to a particular area such as the Sylvester Comprehensive Cancer Center or the Interdisciplinary Stem Cell Institute, are accounted for in their separate Center/Institute Reports.

Individual donors are listed under the corresponding levels of giving from private sources. Contributions made through corporations, foundations, or associations will appear under the listings for those entities.

Please note that all names have been carefully reviewed; nevertheless, errors and omissions may occur.

If your name has been misprinted or omitted, please accept our apologies. Questions should be directed to Stephanie Fernandez, Donor Relations Manager, at 305.243.5009 or s.fernandez13@med.miami.edu.

D epar t men t o f Medi c in e C h air man ’s R e po r t 2014

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University of Miami Health System delivers leading-edge patient care by top-ranked physicians. Powered by the Miller School of Medicine’s groundbreaking research and medical education, UHealth provides life-saving care.

UHealth is a comprehensive network of six hospitals, two dozen outpatient facilities, 1,200 doctors, and more than 8,000 associates. As the region’s only university health system, UHealth is a vital component of the South Florida community.

University of Miami Miller School of Medicine Department of Medicine 1430 NW 11th Avenue, Suite 1001 Miami, Florida 33136 Telephone: 305-243-9120 www.med.miami.edu/medicine/