2023 Annual Report

2023

ANNUAL REPORT 1

LETTER FROM THE DIRECTOR Dear Friends of UCI MIND, We are pleased to bring you this end of year report.

As you know, the mission of UCI MIND is to engage in cutting edge research to discover solutions for Alzheimer’s Disease and Related Dementias. We also devote considerable effort toward community education and training the next generation of researchers to continue ground breaking studies and clinicians to care for people with these diseases. As you will see in this report, 2023 was an exciting and active year for UCI MIND. 2023 was an unprecedented year in Alzheimer’s research. Two new drugs were approved by the FDA to treat Alzheimer’s and we expect a third early in 2024. These approvals break a 20-year drought and signal the beginning of a new phase of progress and advances. UCI

TABLE OF CONTENTS

MIND investigators made key discoveries over the last two decades that were essential to this progress, and we are poised to push further and faster forward in the coming years.

Our work toward these goals was made possible by the outstanding investigators in UCI MIND and by you, our community of supporters. UCI MIND faculty have been awarded hundreds of millions of dollars in research grants from the National Institutes of Health (NIH), the Alzheimer’s Association, and other agencies. But gifts from local philanthropists are often pivotal in making these grant applications successful. We have numerous examples—including the induced pluripotent stem cell core in our ADRC, our MODEL-AD program, and our C2C Registry—where local gifts, often on the order of thousands of dollars, were used by our investigators to collect preliminary data that helped them secure millions and even tens of millions of dollars in NIH support.

4 New Faculty: Bright Minds 6 State of the Field 8 State of the Institute Initiatives 10 Beall Scholar Program 12 RAMP 14 WAM

UCI MIND now includes more than 200 faculty, staff, and trainees who are committed to our mission. We are so grateful to the hundreds of people who are participating in our research studies and the many incredible supporters of our work here in Orange County. From all of us at UCI MIND, we thank you for your continued support and commitment.

Sincerely,

Joshua Grill, PhD Professor of Psychiatry & Human Behavior and Neurobiology & Behavior Carla Liggett and Arthur S. Liggett, MD, Endowed Chair, in honor of Frank M. LaFerla Co-Director, Alzheimer’s Disease Research Center Director, Institute for Memory Impairments and Neurological Disorders

18 Community Supporters 20 Accelerating Discovery Through Philanthropy 22 Annual Southern California Alzheimer’s Disease Research Conference 23 December to Remember Gala

FACULTY Anatomy & Neurobiology

Epidemiology

Neurology

Pediatrics

Aileen Anderson, PhD Tallie Baram, MD, PhD Christine Gall, PhD, Chair Alan Goldin, MD, PhD Kei Igarashi, PhD Gary Lynch, PhD Steven Schreiber, MD John Weiss, MD, PhD Xiangmin Xu, PhD

Maria Corrada, ScD Karen Edwards, PhD Daniel Gillen, PhD Sunmin Lee, ScD

Tallie Baram, MD, PhD Maria Corrada, ScD David Cribbs, PhD Mark Fisher, MD Lisa Flanagan, PhD Claire Henchcliffe, MD, DPhil, Chair Brian Hitt, MD, PhD Claudia Kawas, MD Albert La Spada, MD, PhD Ira Lott, MD Mark Mapstone, PhD Tahseen Mozaffar, MD S. Ahmad Sajjadi, MD, PhD Steven Schreiber, MD Gaby Thai, MD John Weiss, MD, PhD Michael Yassa, PhD

Tallie Baram, MD, PhD Virginia Kimonis, MD Ira Lott, MD Andre Obenaus, PhD

Biological Chemistry Wei Li, PhD

Biomedical Engineering Gregory Brewer, PhD

Chemistry James Nowick, PhD Xiaoyu Shi, PhD

Developmental & Cell Biology Edwin Monuki, MD, PhD Ali Mortazavi, PhD Diane O’Dowd, PhD Xiaoyu Shi, PhD

Environmental & Occupational Health Masashi Kitazawa, PhD Karen Lincoln, PhD, MSW, MA, FGSA

Medicine Masashi Kitazawa, PhD Steven Tam, MD

Microbiology & Molecular Genetics Emiliana Borrelli, PhD Alan Goldin, MD, PhD

Molecular Biology & Biochemistry Charles Glabe, PhD Andrea Tenner, PhD

Neurobiology & Behavior Mathew Blurton-Jones, PhD Jorge Busciglio, PhD Christine Gall, PhD Kim Green, PhD Joshua Grill, PhD Claudia Kawas, MD Frank LaFerla, PhD, Dean Michael Leon, PhD Craig Stark, PhD Vivek Swarup, PhD Leslie Thompson, PhD Marcelo Wood, PhD, Chair Michael Yassa, PhD

Nursing Michael Bueno, PhD, MSN, RN, CNL Sarah Campbell, DNP, MS, BS, AS Jung-Ah Lee, PhD, RN, FGSA, FAAN Adey M. Nyamathi, ANP, PhD, FAAN

Pathology & Laboratory Medicine Elizabeth Head, PhD, Vice Chair Ronald Kim, MD Albert La Spada, MD, PhD Edwin Monuki, MD, PhD, Chair Mari Perez-Rosendahl, MD William Yong, MD

Pharmaceutical Sciences Emiliana Borrelli, PhD

Physical Medicine & Rehabilitation Aileen Anderson, PhD Brian Cummings, PhD

Physiology & Biophysics Kevin Beier, PhD Alan Goldin, MD, PhD

Psychiatry & Human Behavior Joshua Grill, PhD Gary Lynch, PhD Bryce Mander, PhD Joan Steffan, PhD David Sultzer, MD Leslie Thompson, PhD Michael Yassa, PhD

Radiation Oncology Charles Limoli, PhD

Statistics Daniel Gillen, PhD, Chair Bin Nan, PhD

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NEW FACULTY: BRIGHT MINDS

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Michael Bueno, PhD, MSN, RN, CNL

Sarah Campbell, DNP, APRN, FNP-C

Jung-Ah Lee, PhD, RN, FGSA, FAAN

Assistant Clinical Professor, School of Nursing

Associate Clinical Professor, School of Nursing

Professor, School of Nursing

Dr. Bueno studies male caregivers and gender differences in dementia caregiving.

Dr. Campbell’s areas of research interest are geriatrics, health promotion and disease prevention, chronic disease management, integrative approaches to patient care, and the use of shared-decision making to engage patients in self-care.

Dr. Lee uses culturally relevant interventions to improve caregiver health outcomes in diverse communities.

Wei Li, PhD Professor, Bioinformatics, Division of Computational Biomedicine, Biological Chemistry, School of Medicine Dr. Li studies gene regulation in aging and neurological diseases.

Karen D. Lincoln, PhD, MSW, MA, FGSA

Adey M. Nyamathi, ANP, PhD, FAAN

Professor, Department of Environmental and Occupational Health, Program in Public Health

Distinguished Professor, School of Nursing

Dr. Lincoln examines health disparities, including Alzheimer’s disease in Black and African American populations.

Dr. Nyamathi is collaborating with UCI MIND on a new project of robotic care companions.

Xiaoyu Shi, PhD Assistant Professor, Developmental & Cell Biology, School of Biological Sciences; Assistant Professor, Chemistry, School of Physical Sciences Dr. Shi uses microscopy to study cellular mechanisms of aging.

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STATE OF THE FIELD 2023 has been a monumental year in Alzheimer’s disease research and care. Scientists, advocates, and study participants have worked tirelessly for decades to get to this point, but our collective goal is still in front of us which is to eradicate the disease permanently.

55M

people in Orange County with cognitive impairment

3rd

11.5M

Alzheimer’s disease is the

leading cause of death in Orange County

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164K

people worldwide living with dementia

unpaid caregivers in USA

6.7M

people living with Alzheimer’s in the US

14M

By 2050, an estimated people in the US will have Alzheimer’s disease at a cost of $1T

PROGRESS MADE Lecanemab was granted full FDA approval in July, the first such approval in 20 years; it is also the only treatment shown to slow disease.

Brexpiprazole, an atypical antipsychotic, received FDA approval to treat agitation in Alzheimer’s disease.

The Centers for Medicare & Medicaid Services (CMS) will cover FDA approved treatments for Alzheimer’s disease

CMS will cover biomarker testing to determine treatment eligibility.

Dementia Care Coordination programs will also be covered

by CMS to help families navigate the Alzheimer’s disease and related dementias journey.

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STATE OF THE INSTITUTE The Mission of UCI MIND is to advance treatment, prevention, diagnosis, and care for Alzheimer’s through collaborative research and education. This year has shown us we are progressing toward that mission, but substantial more work remains needed.

!

UCI MIND is the only state and federally funded Alzheimer’s Disease Research Center in Orange County

65

Faculty Members

19

Representing

UCI Departments

8

>100 Staff

>40

consecutive years of NIH training grants

1 of 35 NIH-funded ADRCs in the nation

RESEARCH: BENCH TO BEDSIDE Locations where UCI MIND brain specimens have traveled for research.

$47M

We have shared brain specimens and data with 119 institutions around the world.

The Kitazawa lab demonstrated a role of fine particulate matter in neuronal loss in a mouse model of Alzheimer’s disease

Participants Enrolled

MODEL-AD grant was renewed by NIH.

The Blurton-Jones lab created resistant microglia from iPS to help in future drug therapy.

327

Dr. Sultzer was awarded a $200,000 two-year grant from the Diane & Guilford Glazer foundation to study Mild Behavior Impairment (MBI) in older adults.

>200 176 36

Clinical Trials

The Lane lab worked with the Green lab to demonstrate the role of micgrolia in brain response to coronavirus infection

UCI MIND has received the gift of brain donation from more than 1500 research participants.

ADRC Longitudinal Cohort

90+ Study

Down Syndrome

Dr. Blurton-Jones was awarded a $2,220,802 two-year Sponsored Research Agreement in partnership with NovoGlia focusing on the preclinical examination of iPSmicroglia transplantation for neurological disorders.

A new Alzheimer’s Association grant will support the study of recruitment of underrepresented individuals into the AHEAD study.

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COMMUNITY EDUCATION PROPELS PROGRESS UCI MIND partners with the Somang Society, our Asian American Community Advisory Board, as well as Latino Health Access and our Hispanic Advisory Board to increase our cultural sensitivity in research and education, develop new means of reaching diverse communities, and enhance inclusive participation in our studies.

100+ outreach events

5,964 people reached

MINDcast helped facilitate a $1M grant to Steven Tam, MD at UCI Health by state of California to create caregiver training resources.

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TRAINING THE NEXT GENERATION U C I M IN D TR A IN IN G PIPELINE High School

Beall Scholar Program

College

Anteaters Against Alzheimers

Graduate/ Medical School

NIH TITAN T32

NIH SMAART T35

REMIND

Research and Mentorship Program (RAMP)

NIH Neurobiology of Aging and AD T32

Fellowship

Brethren Community Foundation

Early Faculty

Beall Scholar Award IMPACT-AD ADRC Research Education Component

UCI MIND hosts an Emerging Scientists symposium every spring to highlight trainee research

Thank You

Brethren Community Foundation for supporting clinician training Dr. Lorna Carlin, HFC, Lauren Miller Rogen and Seth Rogen for supporting RAMP Joan and Don Beall for supporting the Beall Scholar Program and The Beall Scholar Award

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BEALL SCHOLAR PROGRAM With support from Joan and Don Beall, UCI MIND launched in 2021 the Beall Scholar Program to engage students from local high schools in research and education on Alzheimer’s Disease and Related Dementias to inspire future academic and career choices in geriatric healthcare and research. This 1-week summer training and mentorship program matches students from underrepresented groups with graduate students and postdoctoral scholars from REMIND to help guide them in making important steps towards attending college and pursuing STEM careers.

47

OC students have participated since 2021

94%

identify as non-White or Hispanic

43%

will be the first in their family to attend college

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REMIND trainees will mentor scholars for the 2023 school year

98%

of scholars endorse the statement, “The program made me more prepared to succeed in college.”

“I was drawn to the Beall Scholar Program because it offered an opportunity to bring neurological research and healthcare education access to students from urban, low-socioeconomic schools. Having grown up in a similar environment myself, I know that general education on healthcare, healthcare careers, and scientific research as a career is hard to find.”

- Gema Olivarria, REMIND Co-Chair

provides transportation, food, materials and a stipend for every student

The Beall Scholar Program provides high schoolers from more disadvantaged backgrounds a chance to experience what amazing research is happening at each end of the spectrum, from basic science to caregiving. It gives students opportunities they may otherwise not have access to and this is why I love this program. Coming from a similar background, first-generation university student and low socio-economic status I wish I had something similar to this program when I was at high school.”

- Claire Butler, REMIND Co-Chair “The program was probably one of the best programs I have ever been a part of. I am so grateful for this opportunity and to learn so much about the body’s most interesting organ.”

- Beall Scholar

"It was an amazing experience and I am beyond grateful!"

- Beall Scholar

“It was an amazing learning experience and very fun! I became much more interested in my career choice!”

- Beall Scholar

“The Beall Scholar Program makes education accessible and feasible thanks to funding from Don & Joan Beall which helps us provide students with transportation as well as with an accompanying scholarship so they can offset any financial deficits incurred from time spent at our week-long event.

To me, this represents a great start to addressing health disparities in healthcare and research.”

- Gema Olivarria, REMIND Co-Chair

“Neurodegeneration is a global issue and it is very clearly understudied in marginalized communities.

I believe the Beall Scholar Program to be one of the first steps to helping change this. Having physicians, researchers and community educators that you can’t identify with is detrimental to the success of a community’s engagement, enrollment and dedication to the advancement of a field.”

- Jharrayne McKnight, REMIND Co-Chair 13

RESEARCH AND MENTORSHIP PROGRAM (RAMP) The Research and Mentorship Program (RAMP), a training initiative made possible by support from philanthropist Dr. Lorna Carlin and the nonprofit HFC led by Lauren Miller Rogen and Seth Rogen, pairs 2nd year medical students with UCI MIND faculty mentors to inspire scientific ideas and future careers in dementia research and care. As the field presently grapples with a serious shortage of geriatric healthcare professionals, RAMP aims to create a pipeline of enthusiastic trainees who, motivated by their experiences and mentorship, choose medical careers to advance knowledge and care for older adults.

Finally, after decades of hard work and countless failures, we are at a precipice with Alzheimer’s disease research and treatment. In the last two years, for the first time, we have disease modifying treatments that are FDA approved. Now, more than ever, we need to train the next generation of physician scientists to be prepared to take this fight to the next level by generating important research that will ultimately support development of more efficacious treatments. The RAMP program is central to achieving that goal.

- Bryce Mander (mentor)

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Maxwell Lee How will RAMP enhance your career goals?

RAMP was a great opportunity for me to learn about the process of doing research; Dr. Kawas and her colleagues were great mentors that taught me about how to design a study, critically analyze previous literature in the field, and interpret the results.

Why did you get involved in RAMP? I got involved in RAMP because it was a chance to build on previous Alzheimer’s Disease research while also developing my skills as a researcher more broadly.

How will RAMP improve research and health care in ADRD? RAMP helps to train future researchers and clinicians by giving them a background understanding of ADRD and cultivating strong foundational research practices. Both will be helpful in both performing and understanding future developments in the field, which ultimately will lead to better care and outcomes for patients.

Casey Vanderlip RAMP is a great example of how we can get medical students involved in research. I’ve learned that research is a huge component of the healthcare system. And I think just doing this has motivated me personally to want to do more and more research in the future.

Joey Wong The incidences of Alzheimer’s Disease and Related Dementia will continue to increase with our aging population. So having the support of RAMP and people that are dedicated to trying to address some of the clinical challenges that we see in the clinic, will be enormous help, but also will help fuel the research that is going to inform how we are going to treat and diagnose patients more efficiently and provide them with better care.

Joint endeavor between UCI School of Medicine and UCI MIND

20

medical students have participated since 2020

14

faculty mentors have been paired

7

publications generated

Primary Supporters

Lorna Carlin, MD HFC Lauren Miller Rogen and Seth Rogen

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UCI MIND WAM WOMEN’S INITIATIVE Supporting Promising Preliminary Science UCI MIND and WAM have partnered for the past 6 years to fund pilot research @ $100,000 to understand sex differences in Alzheimer’s disease.

$700K

in support

Dr. Grill and Dr. Chrastil were invited by Maria Shriver (at left) to hear First Lady Jill Biden and DHHS Secretary Javier Baccera to present the new Presidential Initiative signed by President Biden for Women’s Health Research.

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WAM Recipient(s)

Project Title

Matt Blurton-Jones, PhD and Sunil Gandhi, PhD (2018)

Delineating Intrinsic and Extrinsic Origins for Sex Differences in Microglial Response to Brain Injury

Anshu Agrawal, PhD (2019)

Role of Inflammatory Immune Mechanisms in Sex Differences in Alzheimer’s Disease

Elizabeth Chrastil, PhD (2020)

Sex Differences in Spatial Navigation During Aging

Sara C. Mednick, PhD (2020)

The Impact of Sex Hormones on Neural Correlates of Sleep-Dependent Memory During the Menopause Transition

Elizabeth Head, PhD (2021)

Role of Estrogen Receptors on Alzheimer Disease Pathogenesis in Down Syndrome

Masashi Kitazawa, PhD (2022)

Differential Vulnerability to Air Pollution for AD Among Males and Females

Ulrike Luderer, MD, PhD (2023)

Effects of Exposure to Fine Particulate Matter on Gonadal Function and Alzheimer’s Disease Development and Their Interactions

The 2023 grant was awarded to Ulrike Luderer, MD, PhD to examine the effects of exposure to fine particulate matter on gonadal function and Alzheimer’s Disease development and their interactions.

Each of these funded projects received $100,000 for a total of $700,000 (including this year).

“Women are at the epicenter of the Alzheimer’s crisis. That’s why we must be at the heart of the solution.”

- Maria Shriver, Founder of the Women’s Alzheimer’s Movement

“The UCI MIND-WAM Initiative aims to focus the energy of our best scientists on improving understanding of sex disparities in Alzheimer’s disease.”

- Joshua Grill, PhD, Director of UCI MIND

“The quicker we know about why it is that women get Alzheimer’s more, the quicker we can start to create new therapies to treat it.”

- Mathew Blurton-Jones, PhD, UCI MIND-WAM Grant Recipient

DR. CHRASTIL’S WAM PROJECT Dr. Liz Chrastil is an associate professor in the Department of Neurobiology and Behavior in the School of Biological Sciences who studies spatial neuroscience. She was awarded a WAM grant in 2020 to study how menopause impacts navigation abilities and test those relationships with changes in brain structure and function in midlife.

“Navigation is an early marker for Alzheimer’s disease, and many of the brain areas that support navigation are the first to be affected by Alzheimer’s pathology.”

- Liz Chrastil, PhD, UCI MIND-WAM Grant Recipient

“Beyond this study, the WAM funding opened up the possibilities for thinking about how we can address these huge questions about why women have a greater prevalence for Alzheimer’s disease. It has also connected my lab to a network of other scientists working on these questions, which will lead to research possibilities in the future.”

- Liz Chrastil, PhD, UCI MIND-WAM Grant Recipient

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COMMUNITY SUPPORTERS $50,000+

$20K - $49,999K

$10K - $19,999K

Brethren Community Foundation, Inc. Carla Liggett & Arthur S. Liggett, MD Carole Harris Chris Taylor Harriet Harris Harris Taylor Family Foundation Joan and Don Beall Joseph H. Stahlberg Foundation The Crean Foundation Western Geriatric Research Institute

Ann & Charles Quilter Eichenberg-Larson Charitable Foundation Godber Family Foundation J. Stanley & Mary W. Johnson Family Foundation Joseph Gonzalez Lorna Carlin Mary Behrens Peggy Woelke The Chang Family Foundation Ueberroth Family Foundation Warren Taylor

Alvin Pfeiffer Crevier Family Foundation Daniel Clark Donnie Crevier Hilarity for Charity Jeffrey Osborn Kathryn Kendall Kim Jalbert Masonry Fireplace Industries, Inc.

Mohannad Malas Orco Block & Hardscape, Inc. Patrick Quilter Portia Harris Robert Naeve Roger Lisabeth Stephen Hamill Stephen O’Leary Suzanne Melin

$5K - $9,999K Andrew Thorburn

David Zech

John Curci

Michael Rademaker

Sperry Equities, Inc.

Barbara A. Hamkalo Family

Don McLaughlin

Joseph Banning

O’Connor Mortuary

Tenebaum Family Fund

Trust

Harris Taylor Management, Inc.

Julie Hill

R. Sperry

Thomas Sutton

Barbara J. Dove, CPA Accoun-

Herbert Modelevsky

Keith Swayne

Richard Muth

Trico Realty, Inc.

tancy Corporation

James Gianulias

Lisa Applebee

Silverado Senior Living

Vincent Daigneault

Bill Harris

Jo Skibby

Matt Clabaugh

Sperry Commercial, Inc.

$1K - $4,999K Alan Martin Alison Hoeven Allen Yourman Alzheimer’s Association Alzheimer’s Orange County Ann Quilter Anne Jordan Barbara Dove Barbara Hamkalo Barbara Reiland Belmont Village Aliso Viejo CA LP Beverly Newton Brian Hueston

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Brian Liles Bruce Allen Burton Young Candace Wallace Dana Greenia Dana Johnson Daniel Casanova Daniel Flynn David Cribbs Diane Heimstaedt Diane Mondini Edward Escalera Fan-Gang Zeng Geoffrey Gray

Heather Sahargun Helena Yao J. McLaughlin Jacqueline DuPont-Carlson James Zager Jean Vincenzi Jeffrey Taylor John Hornsby John Lomaka Judith Gielow Julie Madonia Kenneth Kast Laura Phillips Lewis Edwards

Linda Crans Lisa Del Rey Loren Shook Lynda Everman Marion Hartwich Mark Wilson Matt Webb Mike Hablitzel Nancy Imlay Edwards Foundation Olague Family Trust Charitable Gift Fund R. Sperry Richard Reigel

Richard Rockwell Robert Elliott Roger Mouton Ryan Radcliff Shannon Ingram Southern California Housing Services Steve Hong Steve Zamolo Susan Reese Tana Mcmillon Valisa Carney

$1 - $999 Alan Terricciano Allison Gates Liljestrom Ana Vargas Andrea Tenner Andres Briseno Andrew Walencewicz Ann Abrams Anne and Joshua Grill April Greer Arnetta Robinson Ayco Charitable Foundation Barbara Ollesheimer Barbara Wall Benedicte Shipley Bert Semler Betty Isa BJ’s Restaurant Foundation Bonnie Lake Bradford Hack Brian Hervey Brittany Bonilla Carol Choi Carol Comparsi Carole Horton-Howe Chanthavone Sirivong Chara Burnstein Chau Ou Cherry Justice ChevronTexaco Corporation Christine Gregg Cleo Dougherty Colleen Brady Concrete Finishing Inc. Costco Wholesale Corporation Cynthia Fritschi-Mathes Dan Hoang

Dan Trinh Daniel Nation Darrell Neft David Lake David Sears David Sultzer Deanna Blanchet Dennis Geiler Dennis Karlin Derrick Wong Diane Bailey Diane Uehlinger Doreen Vail Drew Chesen Edwin Monuki Elain Stephen Elizabeth Bonilla Elizabeth Head Eric Quade Eric Swanson Ernst Stanley Eugenia Jones Eveleen Liu Fay Blix Fetch Robbe Frances Saldaña Frank Kavanaugh Gail Fujimoto Garold Roman George Hill Geraldine Codd Gladys Kempe Glen Hall Grant MacGregor Guthrie and Chapa Families Gwyn Martin Ha Le Hayk Davtyan Herman Algazi

Hornsby Family Trust UTD Howard Huang Irvine Taiwanese Presbyterian Church Jack Carroll Jacob Baisel James Tucker Janice Histon Janice Vitti Rubel Janna Schutlz-Lawler Jaren can den Noort Jason Olin Jason Sastre Jeff Tyler Jeffrey Crozier Jim Coontz Joan Herrick Joan Price Joann Matos Joelle Shoemaker John Gerace John Lisabeth Jonathan Varenchik Joseph White Josiah James Joslyn Aitken Judith MacPheson Judy Capozzola Jullianne Medrano June Kim Karen Held Karen McBride Karen Raab Karen Speros Karen Twichell Karina Recinos Kate Healy Kathrine Lingle Kathryn Healy

Kathy Mcanany Kelson Vibber Ken Thayer Kenneth Hwang Kenneth Pao Kimberly Butrum Kimberly Harvey Kitty Woodworth Kyaw Tin Kymberly Doucette Kymry Fowler Laurence Swaim Linda Harding Linda Murphy Linda Scheck Linda Zahn Liz Donnelly Luter Liu Luxman Nathan Mae Delabarre Malia Tano Marc Beaudry Marc Fielding Maria Lefebvre Maria Minon Marianne Smith Marilyn Conrath Marjon Jahromi Marla Noel Marsha Gallavan Marshall Lee Marvin Telp Mary Ann O’Connell Mary Geib Mathew Blurton-Jones Matt Veltri Matthew Newcomb Matthew Quilter Melissa Van Horn Meredith Jed

Mey Saelee Michael Bolton Michael Gorelick Michael Lee Michael Mossmer Michael Mullin Mike Olague Milton Legome Monica Ochoa Nadine Reyes Cardenas Nancy Sabo Nancy Wong Newcomers and Neighbors of Waco Ok Yon Miller Patricia Clark Patricia Estabrooks Paul Balalis Paul Wexler Paula Ristuccia Regan Wrenn Reiko Kurakazu Richard Dunn Family Foundation Richard Steigner Richard Thompson Riley Ledin Robert Buchel Robert Childers Robert Collier Robert Elliot Robert Robledo Rodrigo Mederios Roger Riley Ronald Guibord Ronald Pierce Rowell Dizon Sal Gonzalez Samantha Dabbs Sandy Kitchner

Sasha Spalding Seth Greiner Sharon Stricker Shelly O’Hara Shirley Cameron Simone Tagne Sindy Thomas Sophia Reyes Stephanie Tyo Stephen Smith Steve Holte Steve Suryan Steven Mink Steven Tam Sue Hagestad Susan Nugent Susan Ridgway Susana Rojas Suzanne Schell Teresa Bailey Teresa Mitchell Theodore Capuano Thomas Wagner Timothy Johnson Tracy Foye United Parcel Service Vicki Faivre Vicky Smith Victoria Von Szeliski Virginia Atherton Wayne Kaplan William Chase William Tefend YourCause, LLC Zachariah Trull

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ACCELERATING DISCOVERY THROUGH PHILANTHROPY

$3.2M raised from donor support

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NETWORKING THROUGH PHILANTHROPY

385 donors

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ANNUAL SOUTHERN CALIFORNIA ALZHEIMER’S DISEASE RESEARCH CONFERENCE

365 attendees

Friday, September 6th, 2024 Hilton Orange County Airport 22

DECEMBER TO REMEMBER GALA

$561K raised for research

Saturday, December 7th, 2024 Balboa Bay Resort 23

On behalf of UCI MIND we thank you for your support and generosity

2646 Biological Sciences III | Irvine, CA 92697-4545

mind.uci.edu 24