1st of 5 gasotransmitter files intended to launch.

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Metabolic gas cycle for nitric oxide synthetase NOS & heme oxygenase HO-1

Large colored structures enzyme (proteins) responsible synthesis of CO & NO

Very specific sites exist in both colored structures accommodate ’much smaller’ gas molecules.

Adapted for teaching from Int J Mol Sci. 2021 Jun 2;22(11):6029.

1st of 5 videos to allow air pollution &industrial hygiene scientists transition

(1) 25-year experience addressing three air contaminants from a fresh viewpoint, noting significance of findings;

(2) Proof-of-concept, estimating knowledge resources & preliminary strategies;

(3) Trajectory of recent studies, resources required, funding sources & add-ons addressing classic toxicity issues;

(4) Commeadvantages of incorporating environmentally-trained scientists;

(5) ‘Blue Sky,’ contemporary views for an adapted audience, hiring, opportunities & limitations.

Fresh professional careers dealing c/ ‘same’ index compounds in new settinsg Wrap-up: Not Pro-or-Con gaso-transmitter efficacy, why not get involved?

Same or different work?

(gaso) Transmitter role changed status of H2S

Who (or what), best suited to monitor small H2S molecule?

But what does this mean exactly – And what other (gaso-) transmitters figure?

So how could someone more familiar c/ detection per H2S noted below move to world of biological mediators

Two basic principles & corresponding references

Neuroscience delivered modern depression & schizophrenia treatments by relying upon a panel of (toxic) biologicals.

Lacking their use, key would not have emerged, permitting useful expansions of the drug formulary.

Physiologic & pharmacologic progress across 2025-30 parallels these precedents

Short panel of air pollutant (molecules) begins with H2S, NO & CO, extending across others, too.

Ambient Air Quality Standards began with SO2 (or H2S), NOx & CO, extending to particulates, ozone & lead.

General duty for a safe & healthy workplace & chemical standards for addressed a similar panel of Asbestos, silica, beryllium, benzene, SO2 (H2S) & solvents like trichlorethylene.

Am J Ind Med. 2022 Feb 14;65(4):286–320.

Prior to FY 2000 most H2S papers often pollution-only

In 21st C. increasingly H2S papers typically (gaso-) transmitter findings – Volume markedly increases

Medline

citation count

Year of publication

Annual NIH funding for hydrogen sulfide-related research per NIH REporter database

Even if limit search to ‘sensors - H2S & biological roles: > 1$M research funding/zero IH/OEHS involvement

A Sensor for quantification of hydrogen sulfide 1Tf - R21

FONTENOT, SEAN ALDON UNIVERSITY OF OREGON

NIGMS $182K

A Sensor for quantification of hydrogen sulfide - 5Tf - R21

JOHNSON, DARREN WILLIAM UNIVERSITY OF OREGON

NIGMS $218K

Delivery H2S: Supramolecular & Enzyme-Triggered Strategies for controlled release - 3Tf - R01

MATSON JOHN VIRGINIA POLYTECHNIC

NIGMS $80K

Hydrogen Sulfide & Carbonyl Sulfide delivery for biological applications -3Tf R01

PLUTH, MICHAEL UNIVERSITY OF OREGON 2023 NIGMS $152K

Transdermal H2S Sensing Device for monitoring peripheral artery disease -5Tf R44

SHEKARRIZ, R.,KANAGY, N. EXHALIX, LLC

Antioxidants (Basel). 2021 Mar 11;10(3):429.

So balance one of ‘our’ papers versus often ‘newer’ their papers noting (gaso-) transmitter roles

‘Kickoff’ 1996 Abe & Kimoura (gaso-) transmitter entry

Balance perhaps 100+ transmitter papers/yr. vs. 5-10 classic

Nitric oxide sees similar rise, again emphasizing transmitter papers NO treatment hypoxic newborns (US FDA 1999)

Rise in carbon monoxide papers less dramatic but similar.

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