FRMC Program

ELI Y. ADASHI. MD, MS, MA

NORBERT GLEICHER, MD

PASQUALE PATRIZIO, MD

RAOUL ORVIETO, MD

Welcome to the 2023 Foundation for Reproductive Medicine Conference

PRELIMINARY PROGRAM "THINK DIFFERENTLY."

DAVID F. ALBERTINI, PHD

ALI H. BRIVANLOU, PHD

WE ARE PLEASED TO BE BACK WITH A NEW PROGRAM OF 22 HOURS OF EDUCATION AND COMMUNICATION, DOCUMENTED BY DIPLOMA Mission

Ability

Judgement

Learning

Progress

Development

Research

The FRMC over three conference days will again link evolving basic science with cutting edge clinic practice, in the process facilitating translational connections between basic science and clinical fertility practice. The purpose is to demonstrate to clinicians what is possible and to inform basic scientists about what is needed. The intent is not to dream about the future, but to demonstrate what is possible now.

Growth

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Community

Conversation

Improvement

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Unity

PRELIMINARY SPEAKERS Howard Bauchner, MD

Robert Casper, MD

Professor of Pediatrics and

Senior Scientist, Lunenfeld-

Publc Health at Boston

Tanenbaum Research Institute;

University Chobanian &

Scientific Director, TRIO IVF;

Avedisian School of Medicine,

Medical Director, Insception-

Editor-in-Chief emeritus, The

Lifebank Cord Blood Bank.

JAMA journals

Norbert Gleicher, MD Medical Director and ChiefScientist, The Center for Human Reproduction; Visiting Researcher, The Rockefeller University, President, The Foundation for Reproductive Medicine, New York, N.Y., USA.

Raoul Orvieto, MD Professor and Head of Infertility and IVF Unit, Department of OBGYN, Sheba Medical Center, Tel-Aviv University, Israel; CoEditor-in-Chief, Reproductive Biology and Endocrinology.

Samuel F. Bakhoum, MD Radiation Oncologist and Researcher, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY,

Uri Elkayam, MD Clinical Professor of Medicine and Obstetrics and Gynecology, University of Southern California Keck School of Medicine. Los Angeles, CA, USA.

Shoukhrat Mitalipov Professor and Director, Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, Oregon USA.

Juan Carlos Izpisua Belmonte, PhD

Nicolas Rivron, PhD

Limor Man, MD, M Med Sci

Sherman J. Silber, MD

David H. Barad, MD, MSc

Head of the San Diego

Group Leader, Laboratory for

Assistant Professor of

Medical Director, The Infertility

Director of Clinical ART and

Research in OB/Gyn, Center

Center of St. Louise, St. Louis,

Senior Scientist, The Center

for Reproductive Medicine,

MO, USA.

for Human Reproduction, New

division of the Altos Institutes of Science, former Professor at the Salk Institute in La Jolla, CA, USA .

Ali H. Brivanlou, PhD Robert and Harriet Heilbrunn Professor, Director The Brivanlou Laboratory of Synthetic Embryology Biology, Rockefeller University New York, N.Y., USA.

Blastoid Development, Institute of Molecular Biotechnology, the Austrian Academy of Sciences (IMBA)/ the Vienna BioCenter (VBC), Vienna, Austria.

York, New York, N.Y., USA.

York, N.Y., USA.

Zeev Shoham, MD

S. Zev Williams, MD, PhD

Professor and Chief, Division

Director Reproductive

Reproductive Endocrinology &

Endocrinology Unit, Kaplan

Wendy D. Havens Associate

Infertility, Department of OBGYN

Hospital, Rehovot and Professor of

and Reproductive Sciences,

Obstetrics and Gynecology

University of Miami Miller School

Hadassah School of Medicine of

of Medicine, Miami, FL

Hebrew University, Jerusalem, Israel.

Eli Y. Adashi, MD, MS, MA

Michelle N. Meyer, PhD, JD

Former Dean of Medicine and Biological Sciences, Professor of Medical

Associate Professor and Chair, Department of

Science, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Member of the National Academy of Medicine (formerly the Institute of Medicine), The Association of

Oncology, Memorial Sloan Kettering Cancer

American Physicians and the American Association for the Advancement

Center

of Science. 2018 recipient of the ASRM Lifetime Achievement Award.

Professor of Women’s Health and Chief of the Division of Reproductive Endocrinology and Infertility at Columbia University Irving Medical Center, New York, N.Y., USA.

Paolo Rinaudo, MD, PhD Professor of Obstetrics & Gynecology, Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, CA, USA.

Jacob Hanna, Founder

Associate Professor and Chair, Department of

Bioethics and Decision Sciences in the College

Bioethics and Decision Sciences in the College

of Health Sciences and Faculty Co-Director of

of Health Sciences and Faculty Co-Director of

the Behavioral Insights Team in the Steele

the Behavioral Insights Team in the Steele

Institute of Health Innovations at Geisinger in

Institute of Health Innovations at Geisinger in

Danville, PA. USA

Danville, PA. USA

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Director and Founder of Fertility Argentina, Buenos Aires, Argentina, and Scientific Director at CEGYR - Eugin group, Buenos Aires, Argentina.

Pasquale Patrizio, MD

United States; Department of Radiation

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Weil Cornell Medicine, New

Demián Glujovsky, MD MSc

David F. Albertini, PhD Editor-in-Chief, Journal of Assisted Reproduction and Genetics (JARG), Senior Visiting Scientist, The Center for Human Reproduction; Stem Cell Biology and Molecular Embryology Laboratory, The Rockefeller University

Antonio Pellicer Associate Professor and Chair, Department of Bioethics and Decision Sciences in the College of Health Sciences and Faculty Co-Director of the Behavioral Insights Team in the Steele Institute of Health Innovations at Geisinger in Danville, PA. USA

PRELIMINARY AGENDA: DAY 1 DECEMBER, 1, 2023 Welcome to the 2023 Foundation for Reproductive Medicine Conference!

8:30 In vitro gametogenesis, - producing eggs and sperm from buccal smears: A summary of the 2023 workshop of the National Academy of Medicine

The “Young Investigator Award”

8:35 Why PGT-A simply cannot work: Physiological, biological, technical, and mathematical reasons

12:00

12:30

Is the concept of embryo selection in IVF still sustainable?

Why are we using extended embryo culture to blastocyst for almost all IVF cycles?

4:00

4:30

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The Opening Lecture: What is wrong with current medical publishing?

8:45 Lunch Symposium: Transferring chromosomal “abnormal” embryos?

1:20

The Breaking News Lecture: Penetrating the black box of implantation

9:30 Can non-invasive PGT-A save PGT-A?

2:00

Another critical look at elective single embryo transfer

The Daily Summary: Q&A with the day’s faculty

5:00

5:30

Human blastoid models to advance our understanding of early-stage embryos

10:00 What is the pregnancy potential of unused and/or discarded “abnormal” embryos after PGT-A?

2:30 Welcome Reception at the hotel

6:00

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Improving organ health and function by programmed rejuvenation

10:30 Pending

3:00

Coffee Break, Poster Viewing & Visit the Exhibition

11:30

Coffee Break, Poster Viewing & Visit the Exhibition

3:30

PRELIMINARY AGENDA: DAY 2 DECEMBER, 2, 2023 The function of micronuclei in cancer cells: Is there relevance to the preimplantationstage embryo?

8:30

Chromosomal analysis of extruded cells/fragments in preimplantationstage embryos

9:00

How follicles and oocytes change with advancing female age: Highly Individualized Egg Retrieval (HIER) as an important step toward “precision medicine”

9:30 Is pregnancy primarily an endocrine or an immunological condition, - and why this matters?

Germline editing for genetic diseases: The 2023 state-ofthe-arts

For how long can IVF cycles be safely delayed in cancer patients to pursue fertility preservation?

12:00

12:20

12:40

Coffee Break, Poster Viewing & Visit the Exhibition

Pending

In vitro germ cell induction from fertile and infertile monozygotic twins

3:00

3:30

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4:00

The public’s opinion on polygenic risk scoring, likely the next big sales item of the genetic testing industry in IVF

10:00

Lunch Symposium

1:00

Some tips and tricks after over 1,000 nuclear transfers in mice

4:30

Coffee Break, Poster Viewing & Visit the Exhibition

10:30 SYMPOSIUM: After all, how effective is oocyte cryopreservation in extending a woman’s reproductive lifespan?

1:20

The importance of insulin-like growth factor 1 (IGF-1) in follicular physiology – an important consideration in using human growth hormone (HGH) in IVF

5:30

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As the primary cause of maternal mortality in pregnancy, why are so many women still dying from various cardio-vascular diseases in pregnancy?

11:00 mtDNA transfer can be horizontal: A mechanism to restore compromised mitochondrial function in embryos?

2:00

The Daily Summary: Q&A with the day’s faculty

6:00

Does pregnancy affect DNA methylation and, therefore, biological age?

11:30 Shining some light into the black box of implantation by using human stem cell-derived blastoids

2:30

Bus pickup for faculty dinner/faculty dinner

6:30

PRELIMINARY AGENDA: DAY 3 DECEMBER, 3, 2023 Are Rotterdam PCOS phenotypes out of date?

8:30

Unintended consequences of industrialization and commoditization of IVF practice: PGT-A as an example

11:00

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Looking at the oocyte and not only the embryo during IVF

9:00

Is in vivo fragmentation of ovarian tissue and/or intraovarian injection of PRP “ovarian rejuvenation.”?

11:30

Issues arising for mankind from increasing utilization of IVF

9:30

Why IVF does not have to be as expensive as it is

12:00

Coffee Break, Poster Viewing & Visit the Exhibition

The future of clinical infertility practice in the U.S.

10:00

10:30

Closing Remarks

12:30

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OUR FIRST SPONSORS AND EXHIBITORS

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WE ARE LOOKING FORWARD TO YOUR REGISTRATION! REGISTER NOW:

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VIEW VENUE:

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PRELIMINARY AGENDA: DAY 3 DECEMBER, 3, 2023 Do PCOS phenotypes really exist or is what we currently describe as PCOS really an amalgam of two distinct genomic entities?

8:30

“Laboratory-developed tests,” a major FDA loophole for the proliferation of useless and/or harmful “addons” to IVF

11:50

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Where do we stand with social eggfreezing, now that we know that it is not very effective at older ages?

9:00

Can in vivo fragmentation of ovarian tissue and/or intraovarian injection of PRP really be considered “ovarian rejuvenation”?

12:10

Societal issues arising for mankind from increasing utilization of IVF

Coffee Break, Poster Viewing & Visit the Exhibition

9:30

10:00

The Daily Summary: Q&A with the day’s faculty

Closing Remarks

12:00

12:30

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Unintended consequences of industrialization and commoditization of IVF practice

10:30