FRMC 2023 Program

PRELIMINARY SPEAKERS

ProfessorofPediatrcsand

PublcHealthatBoston

UniversityChobanian& AvedisianSchoo of Medicine,Edtor-in-Chief emeritus,TheJAMAjournas

Robert Casper,MD

SeniorScientist,LunenfeldTanenbaumResearchInsttute; ScentficDirector,TRIO VF; MedicalDirector,InsceptionLifebankCordBoodBank

UriElkayam,MD

CinicalProfessorofMedicine andObstetricsand Gynecology,Universtyof SouthernCaiforniaKeck SchoolofMedcine Los Angeles,CA,USA.

Norbert Gleicher,MD

MedicalDirectorandChiefScientist,TheCenterforHuman Reproduction;Visiting Researcher,TheRockefeller University,President,The FoundationforReproductive Medicine,NewYork,N.Y.,USA.

foundationforreprodmed.com

DemiánGlujovsky, MDMSc

DirectorandFounderofFertility Argentina,BuenosAres, Argentina,andScientific DirectoratCEGYR-Eugingroup, BuenosAres,Argentina

DavidH.Barad, MD,MSc

DirectorofClinicalARTand

SeniorScientist,TheCenter forHumanReproduction,New York,NewYork,N.Y.,USA.

JuanCarlosIzpisua Belmonte,PhD

SamuelF. Bakhoum,MD HeadoftheSanDiego divisonoftheAltos InstitutesofScience, formerProfessorattheSak InstituteinLaJolla CA,USA .

Edtor-in-Chief,Journalof AssistedReproductionand Genetics(JARG),SeniorVistng Scentst,TheCenterforHuman Reproduction;StemCellBiology andMolecularEmbryology Laboratory,TheRockefeller University

RadationOncoogistandResearcher, HumanOncologyandPathogeness Program Memoria SloanKettering CancerCenter,NewYork,NY,United States;DepartmentofRadiation Oncology,MemorialSloanKettering CancerCenter

RobertandHarrietHeilbrunn Professor DrectorThe BrivanouLaboratoryof SyntheticEmbryoogyBiology, RockefelerUniversityNew York,N.Y,USA.

info@foundationforreprodmed.com

MedicalDrector,The InfertilityCenterofSt Louise St Louis MO,USA

AssistantProfessorof ResearchinOB/Gyn,Center forReproductiveMedcine WelCornellMedicne,New York,N.Y.,USA.

Howard Bauchner,MD

DavidF. Albertini,PhD

AliH.Brivanlou, PhD

ShermanJ. Silber,MD LimorMan,MD, MMedSci

PRELIMINARY SPEAKERS

ProfessorandDirector, CenterforEmbryonic CellandGeneTherapy, OregonHealth&Scence University,Portand, OregonUSA.

ProfessorandHeadofInfertility andIVFUnit,Departmentof OBGYN ShebaMedicalCenter, Te-AvivUnversty Israel;CoEditor-n-Chief Reproductive BiologyandEndocrinology.

ProfessorandChief,Dvsion ReproductiveEndocrinology& Infertility,DepartmentofOBGYN andReproductiveSciences, UniversityofMamiMi erSchool ofMedcine Mami,FL

PaoloRinaudo, MD,PhD

FormerDeanofMedicneandBiologcalScences, ProfessorofMedicalScience,TheWarrenAlpert MedicalSchoolofBrownUniversity,Providence, RhodeIsland,USA;MemberoftheNatonal AcademyofMedcine(formerlytheInstituteof Medicne),TheAssociatonofAmercanPhysicians andtheAmericanAssociationforthe AdvancementofScence 2018recpientofthe ASRMLifetimeAchievementAward

MD ProfessorofObstetrics &Gynecology, ReproductiveSciences, UniversityofCa forna, SanFrancisco(UCSF), SanFrancisco,CA,USA.

WendyD.HavensAssocate ProfessorofWomen’sHealthand ChiefoftheDvisionofReproductive Endocrinologyand nfertlityat ColumbiaUniversityIrvngMedical Center,NewYork,N.Y.,USA.

GroupLeader,Laboratoryfor BlastoidDevelopment,Insttute ofMolecularBotechnology,the AustrianAcademyofScences (IMBA)/theViennaBioCenter

(VBC) Vienna Austria

DirectorReproductiveEndocrnology Unit,KaplanHosptal,Rehovotand ProfessorofObstetricsand GynecologyHadassahSchoolof MedicneofHebrewUniversity, Jerusalem,Israe

Shoukhrat Mitalipov Raoul Orvieto,MD Pasquale Patrizio,MD

Nicolas Rivron,PhD ZeevShoham,

Eli Y. Adashi, MD, MS, MA

S. Zev Williams, MD, PhD

PRELIMINARY AGENDA: DAY 1

DECEMBER,1,2023

Welcometothe 2023Foundation forReproductive Medicine Conference!

8:30

Invitrogametogenesis, -producingeggsand spermfrombuccal smears:A summaryofthe2023 workshopofthe NationalAcademyof Medicine

12:00

The “Young Investigator Award”

Is the concept of embryo selection in IVF still sustainable?

Physiological, biological, technical, and mathematical reasons why PGT-A simply cannot work

TheOpening Lecture:Whythe currentdiscomfort withmedical publishing?

The Breaking News Lecture: TBA

Improvingorgan healthandfunction byprogrammed rejuvenation

CoffeeBreak, PosterViewing& VisittheExhibition 8:35 8:45 9:30 10:00 10:30 11:30

LunchSymposium: Transferring chromosomal “abnormal” embryos?

What happens to poor prognosis patients who use PGT-A?

Whatisthe pregnancypotential ofunusedand/or discarded “abnormal”embryos afterPGT-A?

Can noninvasive PGT-A save PGT-A?

CoffeeBreak, PosterViewing& VisittheExhibition

12:30 1:20 2:00 2:30 3:00 3:30

Why are we using extended embryo culture to blastocyst for almost all IVF cycles?

Anothercritical lookatelective singleembryo transfer

The Daily Summary: Q&A with the day’s faculty

4:30 5:00 5:30

PRELIMINARY AGENDA: DAY 2

DECEMBER,2,2023

Thefunctionof micronucleiin cancercells:Isthere relevancetothe preimplantationstageembryo?

8:30

Germline editing for genetic diseases: The 2023 state-ofthe-arts

12:00

Chromosomal analysis of extruded cells/fragments in preimplantationstage embryos

Howfolliclesand oocyteschangewith advancingfemaleage: HighlyIndvidualized EggRetrieval(HIER)as animportantstep toward“precison medicine”

Polygenic risk scoring – the genetic testing industry’s next big product in IVF?

CoffeeBreak, PosterViewing& VisittheExhibition

Astheprimarycause ofmaternalmortality inpregnancy,whyare somanywomenstill dyingfromvarious cardio-vascular diseasesin pregnancy?

Doespregnancy affectDNA methylationand, therefore, biologicalage?

Invitrogerm cellinduction fromfertileand infertile monozygotic twins

For how long can IVF cycles be safely delayed in cancer patients to pursue fertility preservation?

What ncreasedcancerrisk folowngPPCMand increasedautismriskin offsprngandincreased short-termcancerrskin motherswithinflammatory bowe dseasesuggests aboutthemateria immune systeminpregnancy

LunchSymposium:Are thereembryosthat maybenefitfrom cryopreservationand delayedembryo transfers?

SYMPOSIUM:Afterall, howeffectiveisoocyte cryopreservationin extendinga woman’sreproductive lifespan?

mtDNA transfer can be horizontal: A mechanism to restore compromised mitochondrial function in embryos?

Shining some light into the black box of implantation by using human stem cell-derived blastoids

Losing pregnancies – a matter of chromosomes and/or maternal discretion as recipient of a semiallograft?

Theimportanceof insuln-likegrowth factor1(IGF-1)in follicularphysiology–an importantconsideration inusinghumangrowth hormone(HGH)inIVF

The Daily Summary: Q&A with the day’s faculty

Coffee Break, Poster Viewing & Visit the Exhibition

PRELIMINARY AGENDA: DAY 3

DECEMBER,3,2023

DoPCOSphenotypes reallyexistoriswhat wecurrentlydescribe asPCOSreallyan amalgamoftwo distinctgenomic entities?

8:30

“Laboratory-developed tests,” a major FDA loophole for the proliferation of useless and/or harmful “addons” to IVF

Where do we stand with social eggfreezing, now that we know that it is not very effective at older ages?

Societalissues arisingformankind fromincreasing utilizationofIVF

Coffee Break, Poster Viewing & Visit the Exhibition

Unintended consequencesof industrializationand commoditizationof IVFpractice

Can in vivo fragmentation of ovarian tissue and/or intraovarian injection of PRP really be considered “ovarian rejuvenation”?

The Daily Summary: Q&A with the day’s faculty

Closing Remarks

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