FRMC 2023 Program

ELI Y. ADASHI. MD, MS, MA

NORBERT GLEICHER, MD

PASQUALE PATRIZIO, MD

RAOUL ORVIETO, MD

Welcome to the 2023 Foundation for Reproductive Medicine Conference

PRELIMINARY PROGRAM "THINK DIFFERENTLY."

DAVID F. ALBERTINI, PHD

ALI H. BRIVANLOU, PHD

WE ARE PLEASED TO BE BACK! Mission

Ability

Judgement

Learning

Progress

Development

Research

The FRMC over three conference days will again link evolving basic science with cutting edge clinic practice, in the process facilitating translational connections between basic science and clinical fertility practice. The purpose is to demonstrate to clinicians what is possible and to inform basic scientists about what is needed. The intent is not to dream about the future, but to demonstrate what is possible now.

Growth

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Community

Conversation

Improvement

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Unity

PRELIMINARY SPEAKERS Howard Bauchner, MD

Robert Casper, MD

Professor of Pediatrics and

Senior Scientist, Lunenfeld-

Publc Health at Boston

Tanenbaum Research Institute;

University Chobanian &

Scientific Director, TRIO IVF;

Avedisian School of

Medical Director, Insception-

Medicine, Editor-in-Chief

Lifebank Cord Blood Bank.

emeritus, The JAMA journals

Uri Elkayam, MD Clinical Professor of Medicine and Obstetrics and Gynecology, University of Southern California Keck School of Medicine. Los Angeles, CA, USA.

Juan Carlos Izpisua Belmonte, PhD

David F. Albertini, PhD

Samuel F. Bakhoum, MD

Head of the San Diego

Editor-in-Chief, Journal of

Radiation Oncologist and Researcher,

division of the Altos

Assisted Reproduction and

Human Oncology and Pathogenesis

Institutes of Science,

Genetics (JARG), Senior Visiting

Program, Memorial Sloan Kettering

former Professor at the Salk

Scientist, The Center for Human

Cancer Center, New York, NY, United

Institute in La Jolla, CA, USA

Reproduction; Stem Cell Biology

States; Department of Radiation

.

and Molecular Embryology

Oncology, Memorial Sloan Kettering

Laboratory, The Rockefeller

Cancer Center

University

Norbert Gleicher, MD

Demián Glujovsky, MD MSc

David H. Barad, MD, MSc

Ali H. Brivanlou, PhD

Sherman J. Silber, MD

Limor Man, MD, M Med Sci

Medical Director and Chief-

Director and Founder of Fertility

Robert and Harriet Heilbrunn

Medical Director, The

Scientist, The Center for Human

Argentina, Buenos Aires,

Director of Clinical ART and

Professor, Director The

Infertility Center of St. Louise,

Assistant Professor of

Reproduction; Visiting

Argentina, and Scientific

Brivanlou Laboratory of

St. Louis, MO, USA.

Researcher, The Rockefeller

Director at CEGYR - Eugin group,

University, President, The

Buenos Aires, Argentina.

Foundation for Reproductive

Senior Scientist, The Center for Human Reproduction, New York, New York, N.Y., USA.

Synthetic Embryology Biology, Rockefeller University New York, N.Y., USA.

Medicine, New York, N.Y., USA.

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Research in OB/Gyn, Center for Reproductive Medicine, Weil Cornell Medicine, New York, N.Y., USA.

PRELIMINARY SPEAKERS Shoukhrat Mitalipov

Raoul Orvieto, MD

Pasquale Patrizio, MD

Paolo Rinaudo, MD, PhD

Nicolas Rivron, PhD

Zeev Shoham, MD

Professor and Director,

Professor and Head of Infertility

Professor and Chief, Division

Professor of Obstetrics

Group Leader, Laboratory for

Director Reproductive Endocrinology

Center for Embryonic

and IVF Unit, Department of

Reproductive Endocrinology &

& Gynecology,

Blastoid Development, Institute

Unit, Kaplan Hospital, Rehovot and

Cell and Gene Therapy,

OBGYN, Sheba Medical Center,

Infertility, Department of OBGYN

Reproductive Sciences,

of Molecular Biotechnology, the

Professor of Obstetrics and

Oregon Health & Science

Tel-Aviv University, Israel; Co-

and Reproductive Sciences,

University of California,

Austrian Academy of Sciences

Gynecology Hadassah School of

University, Portland,

Editor-in-Chief, Reproductive

University of Miami Miller School

San Francisco (UCSF),

(IMBA)/ the Vienna BioCenter

Medicine of Hebrew University,

Oregon USA.

Biology and Endocrinology.

of Medicine, Miami, FL

San Francisco, CA, USA.

(VBC), Vienna, Austria.

Jerusalem, Israel.

Eli Y. Adashi, MD, MS, MA

S. Zev Williams, MD, PhD

Former Dean of Medicine and Biological Sciences,

Wendy D. Havens Associate

Professor of Medical Science, The Warren Alpert

Professor of Women’s Health and

Medical School of Brown University, Providence,

Chief of the Division of Reproductive

Rhode Island, USA; Member of the National

Endocrinology and Infertility at

Academy of Medicine (formerly the Institute of

Columbia University Irving Medical

Medicine), The Association of American Physicians

Center, New York, N.Y., USA.

and the American Association for the Advancement of Science. 2018 recipient of the ASRM Lifetime Achievement Award.

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PRELIMINARY AGENDA: DAY 1 DECEMBER, 1, 2023 Welcome to the 2023 Foundation for Reproductive Medicine Conference!

8:30 In vitro gametogenesis, - producing eggs and sperm from buccal smears: A summary of the 2023 workshop of the National Academy of Medicine

12:00 Is the concept of embryo selection in IVF still sustainable?

4:00

The “Young Investigator Award”

8:35 Physiological, biological, technical, and mathematical reasons why PGT-A simply cannot work

12:30 Why are we using extended embryo culture to blastocyst for almost all IVF cycles?

4:30

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The Opening Lecture: Why the current discomfort with medical publishing?

8:45 Lunch Symposium: Transferring chromosomal “abnormal” embryos?

1:20 Another critical look at elective single embryo transfer

5:00

The Breaking News Lecture: TBA

9:30 What happens to poor prognosis patients who use PGT-A?

2:00

Improving organ health and function by programmed rejuvenation

10:00 What is the pregnancy potential of unused and/or discarded “abnormal” embryos after PGT-A?

2:30

The Daily Summary: Q&A with the day’s faculty

5:30

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Human blastoid models to advance our understanding of early-stage embryos

10:30 Can noninvasive PGT-A save PGT-A?

3:00

Coffee Break, Poster Viewing & Visit the Exhibition

11:30

Coffee Break, Poster Viewing & Visit the Exhibition

3:30

PRELIMINARY AGENDA: DAY 2 DECEMBER, 2, 2023 The function of micronuclei in cancer cells: Is there relevance to the preimplantationstage embryo?

8:30 Germline editing for genetic diseases: The 2023 state-ofthe-arts

12:00

In vitro germ cell induction from fertile and infertile monozygotic twins

3:00

Chromosomal analysis of extruded cells/fragments in preimplantationstage embryos

9:00 For how long can IVF cycles be safely delayed in cancer patients to pursue fertility preservation?

12:20

Coffee Break, Poster Viewing & Visit the Exhibition

3:30

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How follicles and oocytes change with advancing female age: Highly Individualized Egg Retrieval (HIER) as an important step toward “precision medicine”

9:30 What increased cancer risk following PPCM, and increased autism risk in offspring and increased short-term cancer risk in mothers with inflammatory bowel disease, suggests about the material immune system in pregnancy

12:40

Pending

4:00

Polygenic risk scoring – the genetic testing industry’s next big product in IVF?

10:00 Lunch Symposium: Are there embryos that may benefit from cryopreservation and delayed embryo transfers?

1:00 Losing pregnancies – a matter of chromosomes and/or maternal discretion as recipient of a semiallograft?

4:30

Coffee Break, Poster Viewing & Visit the Exhibition

10:30 SYMPOSIUM: After all, how effective is oocyte cryopreservation in extending a woman’s reproductive lifespan?

1:20

The importance of insulin-like growth factor 1 (IGF-1) in follicular physiology – an important consideration in using human growth hormone (HGH) in IVF

5:30

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As the primary cause of maternal mortality in pregnancy, why are so many women still dying from various cardio-vascular diseases in pregnancy?

11:00 mtDNA transfer can be horizontal: A mechanism to restore compromised mitochondrial function in embryos?

2:00 The Daily Summary: Q&A with the day’s faculty

6:00

Does pregnancy affect DNA methylation and, therefore, biological age?

11:30 Shining some light into the black box of implantation by using human stem cell-derived blastoids

2:30

PRELIMINARY AGENDA: DAY 3 DECEMBER, 3, 2023 Do PCOS phenotypes really exist or is what we currently describe as PCOS really an amalgam of two distinct genomic entities?

8:30

“Laboratory-developed tests,” a major FDA loophole for the proliferation of useless and/or harmful “addons” to IVF

11:50

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Where do we stand with social eggfreezing, now that we know that it is not very effective at older ages?

9:00

Can in vivo fragmentation of ovarian tissue and/or intraovarian injection of PRP really be considered “ovarian rejuvenation”?

12:10

Societal issues arising for mankind from increasing utilization of IVF

9:30

Coffee Break, Poster Viewing & Visit the Exhibition

10:00

The Daily Summary: Q&A with the day’s faculty

Closing Remarks

12:00

12:30

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Unintended consequences of industrialization and commoditization of IVF practice

10:30

OUR FIRST SPONSORS AND EXHIBITORS

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WE ARE LOOKING FORWARD TO YOUR REGISTRATION! REGISTER NOW:

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VIEW VENUE:

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