A4M MMI - Anti-Aging Medical News - Winter 2019

27TH

ANNUAL WORLD CONGRESS

Dear Colleagues, Welcome to the 27th Annual World Congress on Anti-Aging Medicine. With a growing body of supportive research, a flourishing base of committed practitioners, and an emerging medical landscape full of new clinical possibilities, it is truly an exciting and stimulating time to be involved in the thriving field of Anti-Aging medicine. As the foremost leaders in this field, we at A4M are continuously pushing the boundaries of healthcare towards a more integrative, outcome-centered model that places physicians and patients at the center. With this overarching objective at the very core of our planning initiatives, A4M has committed to spearheading, developing, and hosting the most clinically relevant conferences in Anti-Aging medicine while fostering a strong and supportive community of clinicians; all of whom have a vested interest in remaining at the forefront of the latest medicine and science.

Over the next 3 days you will experience medicine like never before. Our educational team has carefully curated an agenda that will provide you with an optimal educational experience that will allow you to return home with actionable clinical knowledge. This year, World Congress boasts a wide-ranging agenda featuring five pre-conference workshops, a brand new Aesthetics Symposium, an extensive variety of sessions topics, a faculty panel consisting of the premier clinical experts and thought leaders in the field, an Exhibit Hall highlighting the latest resources in Anti-Aging medicine available, and much more.

Our five pre-conference workshops will spotlight the industry’s cutting edge tools, resources and approaches with topics covering Precision Medicine and Diabetes, Hormones and Chronic Disease, Peptides and Aging, Stem Cells, and Practice Management. Our keynote presentations will be led by three clinical powerhouses: Dr. Anna Lembke— a renowned authority in addition medicine, Dr. Robert Pearl — a key authority in healthcare culture and delivery, and Dr. Louise Aronson— an established thought leader surrounding geriatric care and aging. Throughout the conference, attendees will participate in a diverse array of sessions, analyzing the most clinically relevant topics including advanced regenerative medicine, intermittent fasting, cellular disruptions, integrative oncological care, hormonal health, clinical applications of cannabidiol, and bio-identical standards of care, among a multitude of others.

Ronald Klatz MD, DO

Co-Founder

Robert Goldman MD, PhD, DO, FAASP Co-Founder

Each year, the World Congress provides new and returning attendees alike a fresh view at new and transformative clinical possibilities. Rooted in a forward-focused mission to restructure and reshape the practice of healthcare, the 27th Annual World Congress is an invitation to push past the status quo and dare to practice a redefined form of medicine that prioritizes true health and wellness.

On behalf of the entire A4M team we want to thank each of you for bringing vision, expertise and commitment to the event. As the leaders in the field, you have the knowledge, motivation, and experience to wholly transform the modern healthcare landscape - and are truly our greatest asset.

We hope you enjoy your stay in Las Vegas and appreciate your continued support.

In Good Health

ANTI - AGING MEDICAL NEWS • WINTER 2019

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27TH

SHOW REGULATIONS

ANNUAL WORLD CONGRESS

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ANTI - AGING MEDICAL NEWS • WINTER 2019

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ANTI - AGING MEDICAL NEWS | WINTER 2019

TABLE OF CONTENTS 27TH

ANNUAL WORLD CONGRESS

General Information . . . . . . . . . . . . . 4 Product Announcements . . . . . . . . . .78 Exhibit Hall Floormap . . . . . . . . . . . 127 Exhibitor Index . . . . . . . . . . . . . . . 128

ARTICLES

Exhibitor Listings . . . . . . . . . . . . . 131

16

Fasting:

Role in Wellness, Metabolic Health and Inflammation

56

By: Kurt Hong, M.D. Ph.D. F.A.C.N.​

28

Topical Progesterone, Not Synthetic Progestins Or Oral Progesterone, Should Be Considered as A Companion for Estradiol Replacement Therapy to Lower Breast Cancer Risk

72

Aging and the Gut Microbiome By: Kasey Hutchinson, RDN

Coenzyme Q10 and Aging By: Kai Man Yuen, MSc

By: David Zava, PhD

36

Methylation Status as an Indicator of Cellular Aging By: Michael J. Chapman, ND

102

The Science Behind NMN

A Stable, Reliable NAD+ Activator and Anti-Aging Molecule By: Christopher Shade, PhD

42

The Endocannabinoid System and Palmitoylethanolamide (PEA)

By: Elnaz Karimian Azari, PhD

48

Primer on Geranylgeraniol By: Amy Berger, MS, CNS

108

Nitric Oxide: Past, Present and Future

By: Nathan S. Bryan, PhD

PROFESSIONAL

MEDICAL EDUCATION (Non-CME)

THURSDAY | DECEMBER 12TH - 6:15 PM The Trifecta of Lectures on Hormones

Sponsored by:

Presented by: Thierry Hertoghe, MD Locati on:

Galileo Ballroom 903

FRIDAY | DECEMBER 13TH - 6:15 PM Telomere Science – What You Need to Know to Protect the Genome and Mitochondria!

Sponsored by:

Presented by: Ron Rothenberg, MD - of the California Healthspan Insti tute Locati on:

Veronese Ballroom 2402

Make More. Work Less. Gain Support

Sponsored by:

Presented by: Jennifer Landa, MD - BodyLogicMD of Orlando, FL Chief

Medical Offi cer, BodyLogicMD and Kenneth Orbeck, DO - BodyLogicMD of Greenville, SC

Locati on:

Titi an Ballroom 2301

SATURDAY | DECEMBER 14TH - 6:15 PM Fasting and FMD as a Dietary Approach Presented by: James LaValle, RPh, CCN, ND(trad) Locati on:

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Veronese Ballroom 2402

ANTI - AGING MEDICAL NEWS • WINTER 2019

Sponsored by:

WELCOME RECEPTION FRIDAY December 13th 4:00 pm - 6:00 pm Exhibit Hall

HAPPY HOUR SATURDAY December 14th 4:00 pm - 6:00 pm Exhibit Hall

Provided by:

December 15th • 12:40 pm

4

th

PRIZE

PRIZE

1 Year Membership Plus Custom Private Label App Valued at $5,000

28TH

ANNUAL SPRING CONGRESS

PRIZE

6 Month Supply of Franz Skincare Valued at $1,000

Pass Plus 2 Night Stay at the Gaylord Palms Resort, Orlando, Fl. Valued at over $1,500

Must be Present to Win

The Lexus on display and the prize that will be won diff ers from the photograph.

Drawing - Exhibit Hall

TO OUR SPONSORS

THANK YOU!

Sunday December 15th at 12:40 pm Your entry form can be found in your attendee bag or at the A4M/MMI booth #5055.

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FUNCTIONAL TESTING EXPERTS

Ulta Lab Tests

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Know Your Health, One Lab Test at a Time!

27TH

ANNUAL WORLD CONGRESS

PRODUCT

SHOWCASE

(Non-CME)

Location:

Exhibit Hall

FRIDAY

DECEMBER 13TH Sponsored by:

11:30 AM

Premiere Of The World’s First Image Of The Kimera Exosome Presented by: Duncan Ross Sponsored by:

12:00 PM

12:30 PM

Treatments for Anti-Aging, Sirutins activation, and Anti-Senescence Presented by: Ryan Smith

What is a Functional Nutrition Assessment?

Sponsored by:

Presented by: Michael Chapman, ND - Product Development Manager at Genova Diagnostics

Sponsored by:

1:00 PM 4:30 PM

Introducing Bovine Colostrum to Your Patients: From the Practitioner’s Perspective Presented by: Mark Tager, MD, PANEL: Mark Sherwood, ND, Michele Neil-Sherwood, DO

Sponsored by:

Empowering the Patient Presented by: Edward Zimmerman, MD

Sponsored by:

5:00 PM 5:30 PM

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SKIN-CERA®, 100% Natural And Clinically Proven Skin Care Ingredient To Reinforce The Skin Barrier Function And Slow Down The Visible Signs Of Ageing Presented by: Emilie Danckaert, Technical Marketing Manager

How to Create Your Unfair Competitive Advantage with Dr. Oz Presented by: Clint Arthur & Dr. Oz

ANTI - AGING MEDICAL NEWS • WINTER 2019

VIDYA HERBS INC

COMMITTED NATURE

Sponsored by:

SATURDAY TH

DECEMBER 14 Sponsored by:

11:30 AM

Growth Hormone with Focus on ADGH Deficiency Presented by: Ron Rothenberg, MD Sponsored by:

12:00 PM

Cutting Edge Developments in Prenatal Tissue Products

12:30 PM

The Role of Oxygen: The Regenerative Medicine

Presented by: Jonathan J. Hernandez, PhD. Sponsored by:

Presented by: Sandor Kulin, MD Sponsored by:

1:00 PM

The Futuristic of Fotona Physics

4:30 PM

How To Attract Fee Based Elective Medical Cases Through Public Seminars

Presented by: Jeff Nuziard Sponsored by:

Presented by: John McCloskey and Jorge Villar

BETTER PROSPECTS. BETTER RESULTS.

Sponsored by:

5:00 PM

Introducing SoME™: Personalized PRP Skincare That’s All You

5:30 PM

Molecular Hydrogen: The Master Redox Balancer

Presented by: Robert Troell, MD Sponsored by:

Presented by: Todd A. Born, ND, CNS

SUNDAY TH

DECEMBER 15 11:30 AM

Fountain Life: A New Approach To Stem Cell Therapeutics

12:00 PM

Disease Reversal and Regeneration Through Angiogenesis

1:00 PM

Sponsored by:

Presented by: Jeff Emery, VP of Operations/ RD

Sponsored by:

Presented by: Jack Jacobs, MD

Sponsored by:

Fitness In and Out Presented by: Action Martial Arts

ANTI - AGING MEDICAL NEWS • WINTER 2019

15

Fasting:

Role in Wellness, Metabolic Health and Inflammation By: Kurt Hong, M.D. Ph.D. F.A.C.N. Professor of Clinical Medicine . Executi ve Director, Center for Clinical Nutriti on . Keck School of Medicine, USC. Davis School of Gerontology, USC . Member, L-Nutra Scienti fi c Board . The arti cle has been sponsored by L-Nutra The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

INTRODUCTION Fasting is an ancient practice that has its roots in religious and healing practices, tracing back to ancient Greece and days of Hippocrates and Plutarch, who famously said “Instead of using medicine, rather, fast a day.” During 14th century Renaissance, fasting was frequently employed to bring about physical and spiritual renewal, as well as a form of cleanse before warriors were sent to wars. In different religions, the practice of fasting is associated with penitence, including with Muslims during Ramadan and with Roman Catholics during Lent1. Fasting is also practiced by Buddhists during times of intensive meditation as a method of practicing self-control.

The definition of fasting is “to abstain from food.” In the 18th century, fasting was used by European physicians to prevent and treat various illness, ranging from bowel ailments to respiratory diseases to joint symptoms.

More recently, there is ample evidence based on recent clinical studies that fasting or intermittent caloric restriction - when carefully employed by healthcare providers - can improve patients’ wellness and health outcomes.

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The obesity epidemic is now recognized as a global chronic disease with significant metabolic consequences, including coronary heart disease, hyperlipidemia, hypertension,

and diabetes2. While weight loss leads to beneficial changes in these metabolic conditions, the degree of improvement seen in the reduction of blood glucose level, fasting lipids, and inflammation profiles occurs independent of the weight loss3,4. In recent years, various caloric restriction regimens have also been shown to reduce fasting insulin levels and improve hepatic insulin sensitivity, leading to a reduction in visceral adiposity and fatty liver disease3,4.

One of the main benefits of fasting rests in our body’s natural ability to downregulate important nutrientsensing pathways, which in turn stimulate a protective response that results in stress resistance5,. Perhaps the most well-categorized nutrient sensing pathways are the target of rapamycin (mTOR), insulin-like growth factor 1 (IGF-1), and protein kinase A (PKA).

It has been established that the key regulators of these nutrient sensing pathways include glucose, amino acids, and the energy status within the cell5-7.

There are several distinct methods of fasting, including time-restricted eating, modified fasting (including alternate-day fasting and 5:2 regimens), and fasting mimicking diets (See Table 1)3,7,8. These categories are separated by differences in duration of fasting, as well as the different physiological impact induced by distinct dietary restriction. It has been hypothesized that there is an optimal amount of time during

ANTI - AGING MEDICAL NEWS • WINTER 2019

FASTING: Role in Wellness, Metabolic Health and Inflammation

Table 1: Types of Fasting Types of Fasting

Description

Example

Time-Restricted Eating (TRE)

A daily pattern of eating usually conducted between 4-8 hours. The rest of the day would be non-eating hours or fasting.

16:8 Diet or 20:4 (Warrior) Diet

Modified Fasting

A pattern of eating little to no calorie intake conducted 2 to 3 times per week.

Alternate Day Fasting or 5:2 Diet (2 days per week of severe caloric restriction of 500-600 kcal/d)

Fasting Mimicking Diet (FMD)

Dietary plan utilizing specific food ingredients x 5 consecutive days each month, which seeks to replicate the benefits of fasting while still providing calories and nutrients

which the body needs to be in the fasting mode in order to induce prolonged and physiologically pronounced changes. This brief review of the various regimens of fasting aims to define the rationale to support each type of fast as it pertains to optimal metabolic health.

TIME RESTRICTED EATING Time restricted eating (TRE) gains its roots from original studies on circadian rhythms9-10. Disruptions in these daily cycles of ~24 h that control a multitude of physiological and behavioral processes lead to physiologic effects on energy metabolism11, gastrointestinal motility and microbiota12, and sleep-wake cycles. TRE has been defined as a daily eating pattern that involves consumption of all daily nutrients within a < 4-8-hour time frame; there is no distinction as to the composition of the nutrition; rather, the focus is restriction of timing as to when food is consumed. The mechanism by which the circadian rhythm is regulated is complex and can be impacted by nutrient consumption. The transcription activators, which are involved in circadian regulation are closely influenced by the nutrient sensing pathways, including mTOR and AKT, as well as other pathways that are downregulated during fasting. As such, perturbations in timing of food/nutrient intake result in metabolic changes through disruptions of the circadian control and downstream transcription activation.

There is new evidence to support that TRE may help to reinforce circadian rhythmicity leading to weight loss efficacy and improvement in insulin sensitivity.

While clinical data are still sparse in this emerging field, in a recent 16-week feasibility trial, eight overweight individuals were instructed to consume their entire daily

3 consecutive cycles of Fasting Mimicking Diet.

caloric intake over the span of a self-selected 8 h period to determine if this would lead to a reduction in body weight. The study found all subjects not only were able to reduce their eating duration, but this was associated with lost weight (average of 3.27 kg)13. Although the reduction in eating time also induced a decrease in estimated caloric intake - which may have contributed to the weight loss observed - there is new evidence to show that the benefits of TRE may be independent of weight loss. Additional metabolic benefits seen include reduction in total cholesterol, TGs, glucose, insulin, inflammatory biomarkers interleukin 6 and CRP, as well as improvements in insulin sensitivity13,14. The long-term metabolic benefits associated with eating or not eating breakfast are of great research and public interest since previous studies showed greater weight loss and better metabolic profile in those with regular breakfast intake.

In one recent study, participants skipping breakfast were hungrier at lunchtime and had higher plasma levels of ghrelin (important in triggering hunger)15. Fully understanding the potential importance of aligning food intake with daytime hours for metabolic health in humans requires additional large-scale studies.

MODIFIED FASTING (MF) REGIMENS Modified fasting (MF) regimens go by many definitions in the literature, but will be defined as very little (~25% energy restriction) to no calorie intake conducted 2-3 times per week; the majority of studies discussed here will represent the 2-day non-contiguous food restriction each week (5:2 diet) or alternate days of 24-hour water only fast (ADF). Animal studies with MF regimens have shown upregulation of autophagy, stress resistance, and antioxidant activity, as well as extension of lifespan

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

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FASTING: Role in Wellness, Metabolic Health and Inflammation

while decreasing cellular proliferation16,17. However, in clinical studies, the results have been conflicting. In a 1-year trial, 112 subjects who had a BMI between 30-45 kg/ m2 followed the 5:2 diet meal plan18. After 1 year, the treatment group with intermittent caloric restriction had similar weight loss as compared to those on continuous energy restriction (8.0 kg in the MF group versus 9.0 kg, p = 0.6) and improvements in their metabolic profile were also similar. Both groups reduced energy intake by average of 27%. In a separate study, 107 premenopausal women with a BMI between 24-40 kg/m2 followed a 5:2 regimen or continuous calorie restriction over 6 months19. In this study, the women in the MF group had comparable weight loss with the group on continuous calorie restriction (6.4 kg compared to 5.6 kg, respectively; P= 0.4). Comparable body fat reduction and cardiovascular risk marker reduction were also observed between the groups; however, in this one trial, there was slightly greater reduction in fasting serum insulin levels in the MF group19. Given the totality of current evidence, the overall metabolic benefits of MF regimens are not superior to those of continuous energy restriction. As such, additional large-scale prospective studies would be needed to determine true long-term metabolic benefits.

FASTING MIMICKING DIET (FMD) Prolonged fasting (PF) can be described as an extension in duration of the fast, in that it is longer than 2-3 days; PF typically is defined by water only fasting of 4 or more consecutive days. In animal and clinical studies, PF effects a metabolic switch triggering ketosis as well as induction of autophagy and reversal of immunosenescence20,21.

With an extended period of fasting (>72hrs), studies have demonstrated a greater upregulation of aging resistance transcription factors such as FOXO as well as antioxidant enzymes SOD2, Gpx1, and GSR22,23.

Moreover, there is evidence that with an extended >72h fast, there is an augmented down-regulation of key regulators of the nutrient sensing pathways, which accelerate aging, such as IGF-1 and mTOR24.

While metabolic benefits of prolonged fasting (PF) are well defined, barriers of this regimen include poor compliance, increased risk of dehydration and electrolyte imbalance, particularly in the elderly. Due to these difficulties the Fasting Mimicking Diet (FMD) was developed, a novel modality that mimics fasting with a diet while still allowing consumption of limited calories and selected nutrients25. The diet is a five-day regimen of low protein, moderately low carbohydrate, and moderately high fat that is moderately restricted in calories (800-1100 calories). In recent animal studies, the Fasting Mimicking Diet was found to decrease IGF-1, reduce visceral fat mass, extend median lifespan, promote neurogenesis, enable hepatic regeneration, and increase hematopoietic and mesenchymal stem and

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progenitor cells25. In a published clinical study, just following three consecutive cycles of FMD, participants lost an average of 3% of body weight while maintaining lean muscle mass.

Improvements in metabolic parameters such as C-reactive protein, triglycerides, fasting blood sugar, and blood pressure, were observed26. Currently, multiple clinical studies are ongoing to evaluate the effects of the FMD in patients with metabolic syndrome, inflammatory bowel disease, and breast cancer (FMD was previously found to differentially sensitize tumors to chemotherapy in murine models27).

BEYOND METABOLIC BENEFITS Autoimmune and allergic diseases such as lupus, asthma, multiple sclerosis, Hashimoto’s thyroiditis, and rheumatoid arthritis are characterized by dysfunctional T cell regulation, which in part is propagated by age associated inflammation. In the example of multiple sclerosis, which is characterized by T cell mediated demyelination and neurodegeneration of the central nervous system, Fasting, with an FMD regimen, lead to improvement in patient symptoms and positive changes in self-reported HealthRelated Quality of Life (HRQoL) in a clinical trial28.

In the animal model, fasting results in improvements in neuronal regeneration along with remyelination at the demyelinated lesions through simulation of myelin production and suppression of inflammation28.

Similarly, in murine models of rheumatoid arthritis and inflammatory bowel disease, caloric restriction through prolonged fasting resulted in reversal of autoimmunity generated by aberrant pathways of similar T cell activation 29,30 . In a study with 53 RA patients, randomly assigned to either a control diet or prolonged fasting, patients in the fasting group reported significant improvement in clinical parameters as well as laboratory parameters such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) that are correlated with RA disease severity31.

Similarly, a recently published study in patients with inflammatory bowel disease with active flares associated with elevated CRP, intervention with a fasting simulating regimen lead to improvement in multiple inflammatory markers29.

The beneficial immunomodulatory effect seen with disease improvement after fasting is also, in part, related to changes in gut microflora which reduce T cell numbers and intestinal infiltration while promoting gut regeneration32.

WHAT’S NEXT? In murine models as well as other preclinical and preliminary clinical studies involving human subjects, caloric restriction through various fasting regimens has shown early promise in providing health benefits such as weight loss (particularly of visceral adipose tissue), reduction in markers

ANTI - AGING MEDICAL NEWS • WINTER 2019

FASTING: Role in Wellness, Metabolic Health and Inflammation

of systemic inflammation, improvement in metabolic parameters (including blood pressure and fasting glucose), as well as reversal of hepatic steatosis18,20,25,26. However, important clinical questions remain: Is employment of a routine, fasting regimen sustainable for most patients long term? Which patient will most benefit from a specific fasting regimen in promoting his/her metabolic health?

In animal studies, it has been shown that various forms of fasting reduce progression of cancers (including colorectal, liver, breast, and kidney), likely through an impact on inflammatory as well as epigenetic modulation through nutrient sensing pathways33,45. While additional studies are needed, it is exciting to note that the one major metabolic change associated with caloric restriction is a

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Nutrition J. 2010; Nutr J. 2010; 9:57

Singla P, Bardolio A, Parkash AA. Metabolic Effects of Obesity: A review. World J Diabetes. 2010; 1(3): 76-88 Longo VD, Mattson MP. Fasting: Molecular Mechanisms and Clinical Applications. Cell metabolism. 2014;19(2):181-192.

Gustafson C. Alan Goldhamer, dc: Water Fasting—The Clinical Effectiveness of Rebooting Your Body. Integrative Medicine: A Clinician’s Journal. 2014;13(3):52-57.

Efeyan A, Comb WC, Sabatini DM. Nutrient Sensing Mechanisms and Pathways.

Nature. 2015; 517 (7534): 302-310.

Bettedi L, Foukas LC. Growth Factor, Energy, and Nutrient Sensing Signaling Pathways in Metabolic Aging. Biogerontology. 2017; 18(6): 913-929.

Cheng C-W, Adams GB, Perin L, et al. Prolonged Fasting reduces IGF-1/PKA to Promote Hematopoietic Stem Cell-Based Regeneration and Reverse ImmunoSuppression. Cell Stem Cell. 2014;14(6):810-823.

Mattson MP, Longo VD, Harvie M. Impact of Intermittent Fasting on health and Disease Processes. Ageing Res Rev. 2017; 39: 46-58 Zheng X, Sehgal A. AKT and TOR Signaling Set the Pace of the Circadian Pacemaker. Current biology : CB. 2010;20(13):1203-1208.

10. Lamia KA, Sachdeva UM, DiTacchio L, et al. AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation. Science (New York, NY).

2009;326(5951):437-440.

11. Froy O. Metabolism and Circadian Rhythms, Implications for Obesity. Endocrine Review. 2010; 31(1): 1-24.

12. Deaver. JA, Eum SY, Tobroek M. Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition. Front Microbiol. 2018; 9:737

13. Sutton EF, Beyl R, Early KS, et al. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 2018 Jun 5;27(6):1212-1221.

14. Gabel K, Hoddy KK, Haggerty N, et al. Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutrition and Healthy Aging. 2018;4(4):345-353.

15. Kral TV, Whiteford LM, Heo M, Faith MS. Effects of Eating Breakfast Compared with Skipping Breakfast on Ratings of Appetite and Intake at Subsequent Meals in 8-10 Year Old Children. Amer J Clini Nutr. 2011; 93(2) 284-291.

16. Varady KA, Bhutani S, Church EC, Klempel MC. Short-Term Modified Alternate Day Fasting: A Novel Dietary Strategy for Weight Loss and Cardioprotection in Obese Adults. Am. J Clin Nutr. 2009; 90(5):1138-43

dramatic improvement in insulin sensitivity and reversal of age-related oxidative stress – both of which are important drivers of progression of diabetes and cardiovascular diseases. While this represents a tremendous opportunity to improve cardiometabolic health, it is important to appreciate that not all caloric restriction regimens confer similar or equal benefits. As such, future studies evaluating efficacy of fasting interventions for specific diseases or health conditions should carefully be defined based on the type of fasting regimen employed. Given the wealth of new published studies, fasting regimens may present a safe, promising, nonpharmacological approach for weight loss as well as to facilitate metabolic improvements for healthy individuals and certain patient populations.

a randomised trial in young overweight women. International journal of obesity (2005). 2011;35(5):714-727.

20. Balasse EO, Fery F. Ketone Body Production and Disposal: Effects of Fasting, Diabetes, and Exercise. Diabetes Metab Rev. 1989; 5(3) 247-70

21. Anton SD, Moehl M, Donahoo WT, Marosi K, Lee S, Mainous AG, Mattson MP. Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting. Obesity. 2018; 26(2) 254-268

22. Lee C, Safdie FM, Raffaghello L, et al. Reduced IGF-I differentially protects normal and cancer cells and improves chemotherapeutic index in mice. Cancer research.

2010;70(4):1564-1572.

23. Verweij M, van Ginhoven TM, Mitchell JR, Sluiter W, van den Engel S, Roest HP, Torabi E, Ijzermans JN, Hoeijmakers JH, de Bruin RW. Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration. Liver Transpl. 2011 Jun;17(6):695-704.

24. Parrella E, Longo VD. Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain. The Scientific World Journal. 2010;10:161-177.

25. Brandhorst S, Choi IY, Wei M, et al. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan. Cell metabolism. 2015;22(1):86-99. doi:10.1016/j.cmet.2015.05.012.

26. Wei M, Brandhorst S, Shelehchi M, et al. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 Feb 15;9(377).

27. DiBiase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Cabo R, Wei M, Morgan TE, Longo VD. Fasting Mimicking Diet Reduces HO-1 to Promote T Cell Mediated Tumor Cytotoxity. Cancer Cell. 2016; 30(1) 136-146.

28. Choi, IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhosrt S, Suarez J, Morgan TE, Wei M, Bock M, Longo VD. Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Report. 2016; 15(10): 2136-46.

29. Rangan P, Choi IY, Wei M, Navarrete G, Guen E, Brandhosrt S, Pasia G, Maesincee D, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Report. 2019; 26(10) 2704-19 30. Khanna S, Jaswal KS, Gupta B. Managing Rheumatoid Arthritis with Dietary Intervention. Front Nutrition. 2017; 4:52.

31. Kjeldsen-Kragh J, Haugen M, Laerum E, Hovi K, Forre O. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet. 1991;338:899–902

17. Patterson RE, Laughlin GA, Sears DD, LaCroix AZ, Marinac C, Gallo LC, Hartman SJ, Natarajan L, Villasenor A. Intermittent Fasting and Human Metabolic Health. J Acad Nutr Diet. 2015; 115(8) 1203-1212

32. Cignarella F, Cantoni C, Salter A, Dorsett Y, Weinstock GM, Fontana L, Piccio L. Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metab. 2018; 27(6) 1222-1235.

19. Harvie MN, Pegington M, Mattson MP, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers:

34. Lee C, Raffaghello L, Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat Rev Comment Anti-microb Anticancer Chemother.

2012. 5:114–122.

18. Sundfør TM, Svendsen M, Tonstad S. Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: A randomized 1-year trial. Nutr Metab Cardiovasc Dis. 2018 Jul;28(7):698-706.

33. Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011; 30:3305–3316.

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Topical Progesterone, Not Synthetic Progestins Or Oral Progesterone, Should Be Considered as A Companion for Estradiol Replacement Therapy to Lower Breast Cancer Risk.

By: David Zava, PhD The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

In 2002, several large-scale clinical studies were published on the risks of using conventional FDAapproved hormone therapy on breast cancer incidence in postmenopausal women. These were the Women’s Health Initiative (WHI) and Million Women’s (Lancet 2019, Manson 2019) studies published from women using FDA-approved estrogens and progestogens in the United States and Great Britain, respectively. Both studies came to the same conclusion that estrogen therapy, mostly in the form of oral conjugated equine estrogens, by itself did not significantly increase the risk of breast cancer and, to the surprise of many, was associated with a lower risk. However, when estrogen was combined with a synthetic progestin to prevent uterine cancer, the breast cancer risk increased 1.5 to 2-fold. Virtually all forms, of which there are many, of synthetic progestins increased risk about the same extent. Smaller studies suggested that FDA-approved oral progesterone, which was not as widely used, did not increase risk in combination with estrogen therapy. These results led to widescale panic among postmenopausal women using conventional estrogen and progestogen (both synthetic progestins and natural progesterone)

28

therapies and a precipitous drop in prescriptions for these forms of HRT (Lancet 2019). Many women stopped cold turkey all forms of hormone replacement therapy which significantly diminished their quality of life. Adverse estrogen deficiency symptoms that were effectively suppressed with estrogen therapy (e.g. hot flashes and night sweats, sleep disturbances, memory issues, incontinence, vaginal dryness, depression, weight gain, etc.) resurfaced with a vengeance in many women, as did risk for diseases of advanced aging (e.g. bone loss and osteoporosis, cardiovascular disease, stroke, diabetes, senile dementia, Alzheimer’s disease). Women were left frightened between “damned if you do and damned if you don’t”, and a large majority chose not to continue HRT. Many health care providers refused to prescribe hormone therapy until more information about risks were made available through clinical trials.

When these and other studies emerged in 2002, John Lee, MD, and I along with Jenny Hopkins had just published our book entitled, “What Your Doctor May Not Tell You About Breast Cancer: How Hormone Balance Can Help Save Your Life”.

The short of the book is that if your

ANTI - AGING MEDICAL NEWS • WINTER 2019

Topical Progesterone, Not Synthetic Progestins Or Oral Progesterone, Should Be Considered as A Companion for Estradiol Replacement Therapy to Lower Breast Cancer Risk.

hormones are out of balance and you are suffering from symptoms and conditions of advancing age, meaning the transition into menopause and beyond, then you should replenish your hormones back to physiological levels with the same hormones that your body made when you were healthy early middle age. This meant if you were to use estrogen replacement therapy (ERT) you would use estradiol and/or estriol, not a synthetic estrogen like ethinyl estradiol (synthetic estrogen found in birth control pills) or a conjugated horse estrogen (Premarin).

And if you were taking a progestogen to help balance the estrogen and protect against its proliferative effects, you would use bioidentical progesterone, not a synthetic progestin like medroxyprogesterone acetate (Provera) or other synthetic â&#x20AC;&#x153;fakeâ&#x20AC;? progesterone. We already knew from earlier studies published several years before WHI that the synthetic progestins were increasing the incidence of breast cancer (Lee-Zava 2002-Chapter 11). As a research scientist at that time who had spent 20+ years researching and publishing on the role of estrogen and progestogen binding to their receptors and regulating breast cell proliferation and differentiation it was clear from the research literature and smaller clinical studies that the natural hormone progesterone, when delivered topically at a physiological dose (25 mg) protects normal breast tissue from the growth promoting actions of estrogens (Chang 1995). In the breast cancer book we delved into more of what the scientific literature says causes breast cancer and what can be done to help prevent it, like avoiding bad foods and environmental chemicals, making sure you eat good nutritious foods with plenty of colored vegetables, exercising in moderation, getting adequate sleep in the dark, reducing stress as much as possible to lower cortisol-induced estrogen, and taking nutritional supplements that bolster the army of antioxidants that protect against environmental toxins that convert good estrogens to bad ones (Cavalieri 1997, Miao 2019). And if your hormones are out of balance, based on testing their levels in body fluids that represent the bioavailable fraction that enters cells, use physiological amounts of bioidentical hormones to adjust them to levels when you were younger and healthier. What has been crystal clear about bioidentical hormone therapy is that if used correctly and in physiological amounts, it will significantly reduce risk but is no guarantee you will never develop breast cancer.

Fast forward about 20 years to present. Several recent

meta-analyses of the risk of breast cancer with FDAapproved or equivalent, for non-US countries, estrogen and progestogen therapies, shed some new light on risk of HRT for breast cancer. These studies (US, British) mostly just reiterated what we already knew, that estrogen therapy only increases breast cancer risk slightly, but significantly when combined with synthetic progestins (Lancet 2019). The meta-analysis of prospective studies of slightly over 100,000 women using estrogen alone or estrogen combined with progestogens (mostly synthetic), but also oral progesterone, revealed that estrogen therapy alone was only associated with a slight increase in risk, but when combined with a synthetic progestin the risk was approximately doubled after 5 years and doubled again at 10 years of use. No question, synthetic progestins are bad for the breasts and should not be used, especially for women who want to reap the many benefits of hormone therapies their entire lives. Most surprising was that this study also reported that FDA-approved oral bioidentical progesterone, combined with estrogen, carried the same approximate 2-fold higher risk at 5-10 years, but strangely had no increased risk less or greater than that (Lancet 2019). No data was available for topical progesterone combined with estrogens perhaps because very few, if any, clinical studies have been carried out in the US or Great Britain and surrounding European countries using natural progesterone delivered topically.

Despite research and small clinical studies showing that natural progesterone delivered topically directly to the breasts of humans (Chang 1995) and primates protects against estrogen-stimulated cell proliferation of normal mammary epithelial cells, a risk factor for breast cancer, no large prospective randomized clinical studies have been carried out to investigate if topical progesterone therapy is associated with reduced risk for developing breast cancer. The reason for this is not based on science, but economics. Progesterone cannot be patented; however, progesterone combined with a special delivery system can be, as seen with several forms of FDA-approved oral progesterone (Prometrium and Bijuva). Oral progesterone, however, while it protects the endometrial lining, may not raise progesterone to a level high enough to counter the growth-promoting actions of estrogens in the breast tissue (Sitruk-Ware 1997).

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

29

Topical Progesterone, Not Synthetic Progestins Or Oral Progesterone, Should Be Considered as A Companion for Estradiol Replacement Therapy to Lower Breast Cancer Risk.

What is clear is that anything that reduces excessive estrogen burden, be it progesterone, natural or synthetic aromatase inhibitors, diet with more fiber and phytochemicals with colored vegetables, exercise, stress reduction, better sleep habits, etc., translates to lower breast cancer risk. That is what progesterone does. It lowers cell proliferation by down-regulating estrogen receptors, preventing further estrogenmediated stimulation of cell proliferation and redirects differentiation through progesterone interaction with estrogen-regulated cellular progesterone receptors.

Progesterone, via its activation of 17 beta hydroxysteroid dehydrogenase type 2 (see diagram below), also increases the conversion of estradiol, a potent estrogen with high affinity for cellular estrogen receptors, to estrone, a weak inert estrogen (Lee-Zava, 2002).

Progesterone also enhances synthesis of sulfotransferase, an enzyme that then sulfates estrone to estrone sulfate, which is unable to enter cells and serves as a circulating estrogen precursor that must be converted back through two enzymatic steps, sulfatase and 17 beta hydroxysteroid dehydrogenase 1, to estradiol.

Diagram depicts the progesterone-regulated metabolism of E2 to E1 and then to E1-SO4, and then Cyp1A1 and Cyp1B1 conversion, respectively, to 2- and 4-hydroxy estrogens and their further oxidation to 2and 4-quinones. For details see reference (Cavalieri).

What is poorly understood in the scientific/clinical community is that progesterone has dual actions in its effects on estrogen-stimulated cell proliferation. At the lower luteal levels (about 1-10 ng/ml) progesterone synergizes with estrogen to promote cell proliferation

30

with little differentiation. If insufficient progesterone is produced in the presence of high estradiol, as often occurs at perimenopause with compromised luteal function, proliferation may be higher than with estradiol alone (Sitruke Ware). However, at higher luteal levels (10-30 ng/ml) progesterone counters the growth-promoting actions of estrogen by downregulating ER, and through induction of cellular PR redirects the cellular machinery to drive quiescence and differentiation, causing proliferation to come to a halt. If inadequate progesterone is present, as often happens at the transition to menopause (perimenopause) when the corpus luteum fails to produce adequate progesterone but abundant estrogen (low Pg/E2 ratio), then the combination of higher physiological estrogen and lower luteal progesterone (in range, but low-normal) will often result in persistent proliferation and the clinical manifestation of fibrocystic and painful breasts. Excessive proliferation in the absence of progesterone increases risk for gene mutations that have the potential to lead to increased breast cancer risk.

As shown in the diagram above, estrogens in excess, in the absence of progesterone and with exposure to environmental toxins induce the cytochrome enzyme Cyp1B1 that converts beneficial estradiol to potentially toxic and mutagenic 4-catechol estradiol) (see diagram above, Cavalieri 1997, Miao 2019). During this perimenopausal transition is when the rate increase of breast cancer is greatest. Retrospective clinical studies have shown that the higher the luteal progesterone level five years prior to breast cancer diagnosis, the lower the risk of developing breast cancer (Micheli 2004), so it is important to keep progesterone balanced with estradiol, especially during the menopause transition when estrogen metabolite damage is most likely to occur as shown in a recent study on estrogen metabolite formation and breast cancer risk (Miao 2019).

As mentioned, oral progesterone, because it is mostly degraded (90-95%) in the GI tract and liver to metabolites with no capacity to bind and activate PR, may not reach sustained luteal levels to counter the growth-promoting actions of estrogens. Based on saliva, capillary blood, and tissue levels of progesterone only topically applied progesterone (Du 2014) can achieve capillary blood and tissue levels of progesterone high enough to counter the proliferative actions of estrogens.

While small clinical studies have shown that topical

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

Topical Progesterone, Not Synthetic Progestins Or Oral Progesterone, Should Be Considered as A Companion for Estradiol Replacement Therapy to Lower Breast Cancer Risk.

progesterone used at physiological dosing (25-50 mg) effectively reduces estrogen-induced proliferation of the mammary epithelium in humans (Chang 1997), this form of therapy has not been tested in large scale prospective case-control randomized study as with FDAapproved conjugated equine estrogens in combination with synthetic progestins (Lancet 2019, Manson 2019).

What might we learn from what we know about the dual actions of progesterone as it relates to bioidentical estrogen and progesterone therapies for menopausal women and their risk for breast cancer? If we let mother nature be our guide, then we should strive to keep estrogen within the physiological ranges seen throughout a full monthly cycle (about 50-150 pg/ml in serum or about 2% of that seen in saliva = 1-3 pg/ml). For at least half of the month serum or capillary blood (Dried Blood Spot-DBS) progesterone should be about 10-30 ng/ml and saliva 200-600 pg/ ml. This results in a progesterone/estradiol ratio of about 100-300, which is consistent with the ratio seen at the peak of the luteal phase and shown to be protective of the breasts exposed to estradiol (Chang 1997). Excessive estradiol or too little progesterone will result eventually in estrogen dominance and symptoms of estrogen excess (e.g. weight gain in the hips and thighs, fibrocystic and painful breasts, mood swings, etc.). Those are warning signs. High levels of 4-catechol estrogens ratchet that up to extreme warning (Cavalieri 1997) as we have found that 4-catechol estrogens are much higher in women harboring breast cancers than healthy women (Miao 2019).

1997, Leonetti 2003) have shown that physiological dosing with topically delivered progesterone raises the progesterone to physiological levels in tissues of the body such as the salivary gland, capillary beds of the fingertips.

High dose progesterone (> 50 mg), in an attempt to achieve physiological concentrations in serum never happens regardless of the topical progesterone dose (Du 2014). What may seem paradoxical based on serum levels is that excessive progesterone and too little estrogen will eventually keep ER persistently down-regulated and may precipitate symptoms of estrogen deficiency with weight gain, vasomotor symptoms, excessive sleepiness, etc.

Keep in mind that E2 and Pg are produced in a rhythmic pattern each month. Estradiol rises slowly throughout the first half of the cycle and peaks about midway with ovulation. This stimulates growth and proliferation of the uterus and breasts. Progesterone will not work if there is no cellular PR, which requires adequate ER. Excessive Pg down-regulates ER, stopping the cycle.

In summary, maintaining estradiol levels in balance with natural progesterone is necessary to achieve optimal clinical benefits of these hormones. It is the opinion of this author that these goals for optimal progesterone therapy as a breast cancer preventive can best be achieved with topical progesterone, and not oral progesterone, or a synthetic progestin. However, clinical studies with topical progesterone are needed to confirm this hypothesis.

Many health care providers believe that topical progesterone is ineffective because it doesnâ&#x20AC;&#x2122;t raise serum levels. To the contrary, we (Du 2014) and others (Chang

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Chang KJ, Lee TT, Linares-Cruz G, Fournier S, de Lignieres B. Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil Steril. 1995;63(4):785-791.

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Micheli A, Muti P, Secreto G, Krogh V, Meneghini E, Venturelli E, Sieri S, Pala V, Berrino F. Endogenous sex hormones and subsequent breast cancer in premenopausal women. Int J Cancer. 2004;112(2):312-318.

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11. Sitruk-Ware R, Sterkers N, Mowszowicz I, Mauvais-Jarvis P. Inadequate corpus luteum function in women with benign breast diseases. J Clin Endocrinol Metab.

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Methylation Status as an Indicator of Cellular Aging By: Michael J. Chapman, ND The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

In the last two decades, there have been a variety of ways that researchers and clinicians try to gain insight into the factors that lead to, or accelerate, the aging process.

A few examples include telomere analysis, genotyping, oxidative stress evaluation, or even just a thorough cardiovascular assessment. However, recent advancements in technology have increased our capacity to evaluate cellular methylation status through both genotyping and novel biomarker analysis.

The importance of methylation status is not new to the antiaging and functional medicine communities. Proper methylation is crucial in an enormous number of biochemical processes, including creatine production for skeletal muscle contraction, DNA and RNA synthesis, gene regulation (epigenetics), hormone regulation and detoxification, energy production, cell membrane repair, fat metabolism, myelination, and immune function.1-5 Methylation also plays a critical role in vascular endothelial function and maintaining cardiovascular health.

While it is certainly clinically useful to have a firm grasp on all the processes in the body that are affected by

36

methylation perturbation, it is also important to widen the lens so we can put methylation in perspective regarding cellular health overall.

Furthermore, evidence has suggested that methylation dysfunction is associated with the aging process overall, including higher incidence of most age-related pathologies.6 But, how is it that methylation status can be referred to as an indication of cellular health?

METHYLATION AND DNA HEALTH It is well-understood that genome instability is one of the most crucial determinants of cellular senescence, and it is also a large risk-factor for tumerogenesis.7 One factor that contributes to genomic instability is alterations in gene expression within the cell, which is also called epigenetic regulation. Epigenetic regulation is accomplished through DNA methylation.8

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

Methylation Status as an Indicator of Cellular Aging

DNA methylation occurs when methyl groups are attached to specific “non-coding” regions of certain genes. These regions are commonly referred to as CpG islands. Generally speaking, methylation of CpG islands lead a decrease in that particular gene’s expression. The greater number of methyl groups that are attached to these islands, the more gene expression is suppressed. Conversely, removal of these methyl groups increase a gene’s expression.

The relationship between DNA methylation and carcinogenesis is nuanced. For example, hypomethylation of many genes has been implicated in several forms of cancer, whereas other types of cancers have been associated with CpG hypermethylation.9 This does make sense given some genes may code for proteins that are more or less associated with neoplasm (such as the various types of estrogen receptors).

Regardless, attempts have been made to interpret specific patterns of DNA methylation to assess cancerrisk as well as predict overall age.6 While DNA assessment for age-associated methylation dysfunction remains relegated to the realm of researchuse-only, there are metabolic markers that have been shown to correlate well with DNA methylation changes.10 Plasma levels of S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), and the ratio between the two (SAM/SAH) have been used as biomarkers for cellular methylation status.11-13 To note, the SAM/SAH ratio is resistant to fluctuations owing to multiple backup pathways and feedback mechanisms. It is more likely that SAH variability will lead to alterations in the methylation index.14 This is because methylation reactions become compromised with a decreased SAM:SAH ratio and as SAH levels become elevated.15 Therefore, assessing these novel biomarkers in context of the entire methylation pathway is ideal.

METHYLATION AND OXIDATIVE STRESS Another significant contributor to cellular aging is oxidative stress.16 A host of cellular reactions generate large amounts of reactive oxygen species (ROS) every second. The electron-transport chain, in particular, is a source of a tremendous amount of free radical production, which must be neutralized in order to prevent mitochondrial dysfunction.17 One of the main intracellular antioxidants to combat this insult is glutathione.

Oxidative stress has been clinically correlated to innumerable chronic diseases and age-related pathologies.16 Cellular accumulation of ROS causes damage to multiple structures inside the cell, which can culminate in many downstream dysfunctions.16 Common sequelae include protein & lipid damage, altered enzyme activity, and DNA damage.

One important mediator of oxidative stress is the enzyme catechol-o-methyltransferase (COMT).

The COMT enzyme is responsible for phase 2 detoxification of many intrinsic chemical, such as catecholamines. It accomplishes this by methylating these substrates using SAM as a cofactor. Also, proper COMT activity is crucial for adequate elimination of endogenous estrogens which, at high-levels, could be metabolized into DNA adducts (capable of DNA damage).18 Another way that methylation impacts oxidative stress is through its influence on glutathione production.

As mentioned, glutathione is one of the body’s most potent antioxidants. Glutathione is produced in a step-wise fashion from homocysteine (a methylation byproduct and independent cardiovascular risk marker) through a process call transsulfuration. The the first step in transsulfuration is accomplished by the enzyme cystathionine beta-synthase (CBS). To note, CBS activity is dependent on adequate availability of the main methyl donor, SAM.19 Ultimately, when SAM is low, glutathione production will be slowed down. Therefore, poor methylation status can indirectly lead to lower glutathione levels which makes the cell more susceptible to oxidative damage.

ANTI - AGING MEDICAL NEWS • WINTER 2019

37

Methylation Status as an Indicator of Cellular Aging

METHYLATION AND CELLULAR ENERGY Within each cell, there is a vast and dynamic interplay between many biochemical pathways to ensure cellular energy demands are met. Methylation imbalances can influence the ebb and flow of products used by the mitochondria. For example, SAM availability increases the transsulfuration pathway (discussed above). Interestingly, the transsulfuration pathway also contributes to the production of pyruvate used in cellular ATP synthesis. Therefore, adequate SAM can influence pyruvate production for cellular energy metabolism.

Another important methylation product is creatine.

Creatine is as crucial energy source for muscle contraction.

Creatine production in the body is accomplished by subsequent methylation reactions using SAM as a

cofactor. Therefore, an inadequate supply of SAM may impair the systemâ&#x20AC;&#x2122;s ability to adequate generate creatine for optimal muscle contraction which could potentially manifest as muscle weakness.

SUMMARY The previous examples discussed just a few (among many) ways that the methylation cycle relates to optimal cellular health. The methylation cycle assists in maintaining DNA integrity and appropriate expression, mitigating oxidative stress, and cellular energy production. Given this insight, we can make the case that adequate methylation is a hallmark for optimal cellular aging. Therefore, it is critical to consider when addressing all age-related pathologies, as well as the symptoms that accompany the aging process as a whole.

BIBLIOGRAPHY Michael Chapman, N.D. works as Product Development Manager at Genova Diagnostics. Dr. Chapman has no prior publications. mchapman@gdx.net

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ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

Methylation Status as an Indicator of Cellular Aging

1.

Moore LD, Le T, Fan G. DNA methylation and its basic function.

Neuropsychopharmacology. 2013;38(1):23.

2.

Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. ACTA BIOCHIMICA POLONICAENGLISH EDITION-. 2004;51:405-414.

3.

Smazal AL. Oral S-adenosyl methionine (SAM) mediates disruptions in methyl group metabolism due to retinoic acid therapy and alters neurotransmitter metabolism: Implications for major depressive disorder, Iowa State University; 2013.

4.

Lawson BR, Eleftheriadis T, Tardif V, et al. Transmethylation in immunity and autoimmunity. Clinical Immunology. 2012;143(1):8-21.

5.

Abu-Lebdeh HS, Barazzoni R, Meek SE, Bigelow ML, Persson X-MT, Nair KS. Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes. The Journal of Clinical Endocrinology & Metabolism.

2006;91(9):3344-3348.

6.

Jung M, Pfeifer GP. Aging and DNA methylation. BMC Biol. 2015;13:7-7.

7.

Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing.

Nature. 2007;448(7155):767-774.

8.

Deroo LA, Bolick SC, Xu Z, et al. Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study. Carcinogenesis. 2014;35(2):333-338.

9.

Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nature genetics. 1994;7(4):536-540.

10. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. The Journal of biological chemistry. 2000;275(38):29318-29323.

11. Hao X, Huang Y, Qiu M, et al. Immunoassay of S-adenosylmethionine and S-adenosylhomocysteine: the methylation index as a biomarker for disease and health status. BMC research notes. 2016;9(1):498.

12. Mason JB. Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. The Journal of nutrition. 2003;133 Suppl 3:941s-947s.

13. James SJ, Cutler P, Melnyk S, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. The American journal of clinical nutrition. 2004;80(6):1611-1617.

14. Guerra-Shinohara EM, Morita OE, Pagliusi RA, Blaia-dâ&#x20AC;&#x2122;Avila VL, Allen RH, Stabler SP. Elevated serum S-adenosylhomocysteine in cobalamin-deficient megaloblastic anemia. Metabolism-Clinical and Experimental. 2007;56(3):339347.

15. Williams KT, Schalinske KL. New insights into the regulation of methyl group and homocysteine metabolism. The Journal of nutrition. 2007;137(2):311-314.

16. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing.

Nature. 2000;408(6809):239-247.

17. Kudryavtseva AV, Krasnov GS, Dmitriev AA, et al. Mitochondrial dysfunction and oxidative stress in aging and cancer. Oncotarget. 2016;7(29):44879-44905.

18. Zahid M, Kohli E, Saeed M, Rogan E, Cavalieri E. The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity. Chemical research in toxicology. 2006;19(1):164-172.

19. Pey AL, Majtan T, Sanchez-Ruiz JM, Kraus JP. Human cystathionine betasynthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM. The Biochemical journal. 2013;449(1):109-121.

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

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The Endocannabinoid System and Palmitoylethanolamide (PEA)

By: Elnaz Karimian Azari, PhD The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

The endocannabinoid system (ECS) is an important physiological system that regulates and balances a wide range of physiological functions in the body.1 Research on ECS has led to the identification of not only endocannabinoids such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), but also endocannabinoidlike lipid mediators such as palmitoylethanolamide (PEA). These endocannabinoid-like compounds often share the same metabolic pathways of the endocannabinoids but lack binding affinity for the classical cannabinoid receptor type 1 and type 2 (CB1 and CB2), as do endocannabinoids.2 PEA can naturally occur in lipid extracts of foods such as egg yolk, peanut oil or soybean lecithin.3 Endogenously, PEA is biosynthesized from the saturated fatty acid palmitic acid in various cell types, such as immune cells, neurons and microglias. These cells are relevant to chronic pain and inflammation signaling.2 PEA can be detected in various tissues and body fluids.2 When facing external stressors such as tissue damage and inflammation, endogenous levels of PEA change in order to maintain cellular homeostasis.4

42

MECHANISMS OF ACTION OF PEA PEA is produced ‘on demand’ from membrane phospholipids and exerts its pharmacological effects via multiple mechanisms: Preclinical studies have demonstrated the effect of PEA on antinociceptive activities and inhibition of peripheral inflammation as well as neuroprotective actions.5-7 The anti-inflammatory effects of PEA were first identified by modulation of mast cell activation and degranulation.8,9 Later, the direct receptor activation, including the nuclear receptor peroxisome proliferator activated receptor-α (PPAR-α) and G-protein coupled receptor 55 (GPCR55) was identified.

The binding of PEA to selective receptors present on the surface of neurons and immune cells activates signaling pathways leading to inhibition of expression of proinflammatory genes and pain related signaling, both in central and peripheral nervous system.10 In addition, PEA supports the ECS via the entourage effect: PEA increases levels of AEA via inhibiting the expression of fatty acid amide hydrolase (FAAH),

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The Endocannabinoid System and Palmitoylethanolamide (PEA)

the enzyme responsible for the breakdown of AEA, thereby indirectly activating classical cannabinoid receptors and increasing AEA actions.9 PEA enhances 2-AG- and AEA-induced activation and desensitization of the transient receptor potential vanilloid receptor type 1 (TRPV1) channels, thus potentiating TRPV-1-mediated anti-inflammatory or analgesic actions.11 PEA indirectly increases CB2 receptors expression or activates TRPV1 channel via PPAR-α.2 Accumulating data indicate that PEA’s therapeutic actions are mediated by synergistic interactions among these mechanisms. For example, in a mouse model Subject Condition (sample size) Chronic sciatic pain (n=636)13 Fibromyalgia (n=407)14

Fibromyalgia (n=35)15

Chronic low back pain (n=55)16

Study Design; PEA dosage

of Parkinson Disease, chronic PEA administration has been shown to protect dopaminergic neurons and ameliorate motor performance.7 These actions may be mediated by PEA acting through both direct and indirect interactions with different receptors, such as cannabinoid CB2 and PPAR-α.12

PEA CLINICAL EVIDENCE The health benefits of PEA have been studied in different areas such as pain management, immune modulation and neuroprotection. Key human clinical studies involving PEA are summarized below.

Main Findings

DB RCT; 300 or 600 mg/d for 3 weeks

Pain was significantly reduced in a dose-dependent manner

OS; 600 mg t.i.d. for 10 d followed by 600 mg b.i.d. for 20 d, and 600 mg/d for 15 mo as add-on therapy

Pain intensity as measured by VAS significantly reduced over time Quality of life as measured by FIQ significantly improved over time

OS; 600 mg b.i.d. the 1st mo and 300 mg b.i.d. the next 2 mo as add-on therapy

PEA administration for 3 months significantly reduced pain symptoms as assessed by tender points and VAS compared with prior to PEA administration

OS; 600 mg b.i.d. for 6 mo as add-on therapy

Pain intensity as measured by VAS significantly reduced over time Permanent functional disability as evaluated by ODQ significantly improved over time Addition of PEA allowed a dose reduction over time in existing therapy (analgesic treatment)

Chemotherapy-induced neuropathy (n=20)17

OS; 300 mg b.i.d. for 2 mo

Pain and neurophysiological measures (function of nerve fiber A-α, A-β, A-δ subtypes) significantly improved over time

Endometriosisrelated chronic pelvic pain (n=81)18

Review of 4 diverse studies (2 RCTs and 2 OS); PEA+PO* (400 mg+40 mg) b.i.d. for 3 mo

A clinically relevant improvement of chronic pelvic pain and dysmenorrhea was observed

Carpal tunnel syndrome (n=56)19

DB RCT; 600 mg/d for 30 d

Sensory conduction was improved with PEA, increased cross section of median nerve with PEA, pilot and underpowered for significance

Carpal tunnel syndrome (n=61)20

DB RCT; 300 mg b.i.d. for 60 d

An improvement in functional status as assessed by BCTQ was observed

Geriatric non-cancer chronic pain (n=10)21

N-of-1 trial; Two 3-wk PEA 600 mg b.i.d. versus placebo comparison, separated by 2-wk washout periods (other medications p.r.n.)

3 subjects did not complete the trial: 1 had diarrhea (under placebo), 1 excluded for low adherence, and 1 for intercurrent pneumonia.

A significant improvement in pain intensity of function in 3 of 7 subjects who completed the trial

ANTI - AGING MEDICAL NEWS • WINTER 2019

43

The Endocannabinoid System and Palmitoylethanolamide (PEA)

TMJ inflammatory pain related to OA or arthralgia (n=24)22

Knee OA (n=111)23

DB RCT; 300 mg a.m. and 600 mg p.m. for 7 d and then 300 mg b.i.d. for 7 more d.

Comparison group received ibuprofen 600 mg t.i.d. for 14 d

DB RCT; 300 mg/d, 600 mg/d or placebo for 8 wk

A significant reduction in the WOMAC total score, pain score and stiffness score in both PEA groups compared with placebo A significant reduction in the WOMAC function score in the 600 mg PEA group compared with placebo Evaluations for "worst pain" were significantly reduced in both PEA groups compared with placebo A significant reduction in anxiety as assessed by DASS in both PEA groups compared with placebo

Review of 6 DB RCTs; 6001800 mg/d for 12 d to 9 wk

2 studies found that adult individuals receiving PEA had significantly fewer episodes of fever, headache, and sore throat, compared with placebo. PEA also reduced total number of sickness days and the incidence rate 3 studies found that adult individuals in the PEA group had significantly less symptoms and were less often diagnosed as flu patients 1 study involving children (age 11-15) found that PEA reduced incidence of common cold compared with placebo

Glaucoma (n=129)25

Review of 4 DB RCTs; 600 mg/d for 2 wk to 6 mo

1 study in individuals with glaucoma and ocular hypertension found that PEA reduced intraocular IOP) compared with placebo 1 study in ocular hypertensive patients found that PEA reduced IOP and significantly improved FMD values compared with placebo 1 study in individuals affected by normal-tension glaucoma found that PEA reduced IOP and improved visual field indices compared with placebo 1 study in individuals undergoing procedure for the prevention of primary closed-angle glaucoma found that PEA attenuated postsurgery increase in IOP compared with placebo

Parkinson's disease (n=30)26

OS; 600 mg b.i.d. for 3 mo followed by 600 mg q.d. for up to 12 mo as add-on therapy

Compared with baseline; addition of PEA led to a significant and progressive reduction in both motor and non-motor symptoms as assessed by MDS-UPDRS

OS; PEA+Lut† (1400 mg+140 mg) for 60 d as add-on therapy

An improvement in neurological status (assessed by CNS), cognitive abilities (by MMSE), degree of spasticity (by AS), and pain (by NRS) was observed after 30 d An improvement in independence in daily living activities (assessed

by BI) was observed at 30 d which continued to improve at 60 d

Common cold and influenza (n=3627)24

Stabilized stroke subjects in neurorehabilitation (n=250)27

Relapsing-remitting multiple sclerosis (n=29)28

DB RCT; 600 mg/d for 1 year as add-on therapy

A significant reduction in circulating pro-inflammatory cytokines (IFN-γ, IL-17 and TNF-α) compared with placebo A significant improvement in quality of life (assessed

by MSQoL-54) compared with placebo An improvement in pain at the existing IFN-β1a injection site (a common adverse event of IFN-β1a)

AS: Ashworth Scale; BCTQ: Boston Carpal Tunnel

Impact Questionnaire; FMD: flow-mediated dilation; IOP:

Neurological Scale; d: day (or days); DASS; Depression

Society/Unified Parkinson’s Disease Rating Scale questionnaire;

Syndrome Questionnaire; BI: Barthel Index; CNS: Canadian Anxiety Stress Scale; DB: double-blind; FIQ: Fibromyalgia

44

After 14 d, PEA significantly decreased pain intensity compared with ibuprofen Maximum mouth opening (indication of pain relief ) at 14 d was significantly greater in PEA group compared with ibuprofen group

intraocular pressure; MDS-UPDRS: Movement Disorder MMSE: Mini Mental State Examination; mo: month (or

ANTI - AGING MEDICAL NEWS • WINTER 2019

The Endocannabinoid System and Palmitoylethanolamide (PEA)

months); MSQoL-54: Multiple Sclerosis Quality of Life-

SAFETY

54 questionnaire; NRS: Numeric Rating Scale; ODQ:

Oswestry Disability Questionnaire; OS: observational study; OA: osteoarthritis; RCT: randomized controlled trial; TMJ: temporomandibular joint; VAS: Visual Analogue Scale; wk:

week (or weeks). *PO: trans-polydatin, a precursor of resveratrol; WOMAC: Western Ontario and McMaster Universities

In a meta-analysis of 12 human clinical studies, PEA was generally well-tolerated, and no serious, non-serious, or suspected adverse events associated with PEA (dose as high as 1200 mg/day for 365 days) were seen.29

Osteoarthritis Index. †Lut: luteolin, an antioxidant flavonoid.

REFERENCES 1.

Aizpurua-Olaizola O et al. Drug Discov Today. 2017;22(1):105-110.

15. Del Giorno R et al. Pain Ther. 2015;4(2):169-178.

2.

Iannotti FA et al. Prog Lipid Res. 2016;62(107-128.

16. Passavanti MB et al. BMC Anesthesiol. 2017;17(1):171.

3.

Kuehl FA et al. Journal of the American Chemical Society.

1957;79(20):5577-5578.

17. Truini A et al. CNS Neurol Disord Drug Targets. 2011;10(8):916-920.

4.

Skaper SD et al. Philos Trans R Soc Lond B Biol Sci. 2012;367(1607):33123325.

5.

De Filippis D et al. J Neuroendocrinol. 2008;20 Suppl 1(20-25.

6.

Koch M et al. Neurotox Res. 2011;19(2):330-340.

7.

Esposito E et al. PLoS One. 2012;7(8):e41880.

8.

Mazzari S et al. Eur J Pharmacol. 1996;300(3):227-236.

9.

Petrosino S et al. Br J Pharmacol. 2017;174(11):1349-1365.

10. Lo Verme J et al. Mol Pharmacol. 2005;67(1):15-19.

11. Petrosino S et al. Br J Pharmacol. 2016;173(7):1154-1162.

12. Skaper SD et al. Mol Neurobiol. 2013;48(2):340-352.

13. Guida G et al. Dolor Investigación Clínica & Terapéutica. 2010;25(1):35-42.

14. Schweiger V et al. CNS Neurol Disord Drug Targets. 2019:[Epub ahead of print].

18. Indraccolo U et al. Ann Ist Super Sanita. 2017;53(2):125-134.

19. Coraci D et al. Rheumatol Int. 2018;38(7):1307-1309.

20. Faig-Marti J et al. J Orthop Traumatol. 2017;18(4):451-455.

21. Germini F et al. Drugs Aging. 2017;34(12):941-952.

22. Marini I et al. J Orofac Pain. 2012;26(2):99-104.

23. Steels E et al. Inflammopharmacology. 2019;27(3):475-485.

24. Keppel Hesselink JM et al. International Journal of Inflammation.

2013;2013(8.

25. Keppel Hesselink JM et al. Journal of Ophthalmology. 2015;2015(9.

26. Brotini S et al. CNS Neurol Disord Drug Targets. 2017;16(6):705-713.

27. Caltagirone C et al. Transl Stroke Res. 2016;7(1):54-69.

28. Orefice NS et al. Neurotherapeutics. 2016;13(2):428-438.

29. Paladini A et al. Pain Physician. 2016;19(2):11-24.

Elnaz Karimian Azari, PhD is Therapeutic Platform Lead for Cardiometabolic and Obesity platforms at Metagenics. She earned her PhD in Nutritional Physiology from ETH Zurich in Switzerland. elnazkarimianazari@metagenics.com.

ANTI - AGING MEDICAL NEWS • WINTER 2019

45

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Primer on Geranylgeraniol By: Amy Berger, MS, CNS The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

Geranylgeraniol (GG) is a compound synthesized endogenously in the human body via the mevalonate pathway—the same biochemical pathway by which cholesterol, heme A, dolichol and ubiquinone (CoQ10) are synthesized.

As such, it plays a critical role in tissue systems and metabolic processes throughout the body, including healthy mitochondrial function and the generation of ATP. GG occurs naturally in various foods (e.g., flax, sunflower and olive oils, select medicinal herbs), but the majority is synthesized endogenously.

GG is an essential building block for production of CoQ10, conversion of vitamin K1 to K2, and for protein synthesis and post-translational modification. Synthesis of GG declines naturally during aging and is inhibited by use of certain pharmaceutical drugs, namely, statins and bisphosphonates.

A reduced supply of this crucial and versatile compound may contribute to some of the physical decline and increased risk for cardiometabolic disease seen during aging.

EFFECT OF COMMONLY PRESCRIBED DRUGS ON SYNTHESIS OF GG AND DOWNSTREAM PRODUCTS: STATINS & BISPHOSPHONATES 48

Statin drugs exert their effects early in the mevalonate pathway (via inhibition of the enzyme HMG-CoA reductase), far upstream of where GG and its byproducts are produced. Synthesis of all compounds produced after this step may be reduced, which likely contributes to the noted neuromyotoxicity and mitochondrial toxicity of statins.1,2 Decreased synthesis of CoQ10 may result in depressed cellular energy generation via impaired mitochondrial respiration, with cascading effects on numerous tissue systems. A consequence of reduced GG synthesis due to statin use may include decreased endogenous vitamin K2 production, which may play a role in vascular calcification and, paradoxically, atherosclerosis.3 The exact mechanisms behind the myopathy and myotoxicity some statin users experience are not known for certain but it’s possible they result from inadequate synthesis of GG and, as a result, an inadequate pool of CoQ10. Researchers note evidence points to GG “as the principal target of statin-dependent myotoxicity,”4 and statin-induced muscle damage “is the result of a geranylgeranylation defect”5—potentially due to an inadequate supply of GG. Beyond statins’ effect on CoQ10, their role in decreased heme A

ANTI - AGING MEDICAL NEWS • WINTER 2019

Primer on Geranylgeraniol

synthesis may further contribute to compromised mitochondrial function.6 Heme A is an essential component of complex IV of the electron transport chain (cytochrome C oxidase), one of the major regulatory sites for oxidative phosphorylation and mitochondrial respiration. Deficiency of cytochrome C oxidase increases mitochondrial apoptosis in response to oxidative stress.

Bisphosphonate drugs are another category of pharmaceuticals that interfere with endogenous synthesis of GG. Nitrogen-containing bisphosphonates (NBPs) also exert their effects via the mevalonate pathway, but the enzyme target of these drugs is farnesyl pyrophosphate synthase (FPPS) rather than HMG-CoA reductase so the mechanism is different from that of statins. FPPS is involved in the steps immediately preceding GG synthesis.

A noted adverse effect of NBP use is osteonecrosis of the jaw (ONJ). Effective treatments for this are lacking, and GG has been identified as a potential preventive and therapeutic agent.7 Most of the research in this area to date has been done in rodents and cell cultures but results are promising, as discussed in the next section.

Inhibition of enzymes in the mevalonate pathway may reduce conversion of vitamin K1 to the K2 form, the latter being instrumental in bone mineralization.8 Vitamin K2-dependent enzymes play essential roles in calcium trafficking and a deficit of enzyme activity may contribute to reduced bone mineralization with concurrent vascular and soft tissue calcification—a phenomenon called the “calcium paradox.”9,10 Vitamin K2 appears to promote the transition of osteoblasts to osteocytes and may also limit the synthesis of osteoclasts11—precisely something that would be desirable in treating osteoporosis.

Vitamin K1 accounts for over 90% of dietary vitamin K but K2 (found in aged cheese, animal fats and proteins, and fermented vegetables12,13), makes up over 90% of tissue vitamin K stores. K2 is derived from K1 via enzymatic processes that require protein modification through geranyl pyrophosphate and farnesyl pyrophosphate, the latter being the enzyme inhibited by NBPs.14 This likely explains the reduced K2 synthesis seen with NBPs and also with statins.3

POTENTIAL THERAPEUTIC ROLE FOR GG Animal models and cell studies show that, when given in combination with statins, GG increases mitochondrial

respiration and restores ubiquinone synthesis without negatively impacting statins’ cholesterol-lowering effects.

Administration of GG to statin-treated human neurons decreased expression of inflammatory markers and reduced mitochondrial damage, facilitating maintenance of proper mitochondrial structure and function.15 In human monocytes and liver cells, GG reversed mevastatin-induced reductions in ubiquinone synthesis and mitochondrial electron transport that typically lead to cell death, also without impeding the drug’s cholesterol-lowering property.16 Notably, addition of GG was more effective than addition of exogenous CoQ10 itself for attenuating these adverse effects, leading researchers to state that compared to ubiquinone, “Geranylgeraniol may be a more useful and practical means of limiting the toxicities of statins, without reducing their efficacy as cholesterol lowering agents.”16 Regarding a potential role for GG in mitigating the adverse effects of NBPs, GG was shown to reverse the effects of these drugs on reduced angiogenesis,7 which has been hypothesized as one of several mechanisms contributing to ONJ.17 GG has also been shown to reverse the negative effects of NBPs in human fibroblasts, osteogenic cells and HUVEC cells.18 Endothelial progenitor cells (EPC) cotreated with NBPs and GG showed significantly increased cell viability, migration ability and increased EPC colony density (decreased apoptosis) compared to non-GG-treated controls, effectively reversing the negative effects of NBPs. Similar results have been demonstrated for GG reversing the negative effects of NBP on human alveolar osteoblasts, periodontal ligament fibroblasts and oral keratinocytes.19-21

STEROID HORMONE SYNTHESIS GG may have a role in supporting steroid hormone synthesis. This process naturally declines during aging and may also be reduced as a side effect of statin drug use.

By inhibiting cholesterol synthesis, statins may impair production of steroid hormones made from cholesterol, such as progesterone and testosterone. A systematic review and meta-analysis of randomized controlled trials on the effect of statins on testosterone in men and women found that statins do have a mild testosterone-lowering effect, but the clinical significance of this may differ among individual patients.22 The average reduction was low but individual patients may experience larger decreases, potentially resulting in reduced libido,23 erectile dysfunction (ED)24 and other complications, particularly in older men and those

ANTI - AGING MEDICAL NEWS • WINTER 2019

49

Primer on Geranylgeraniol

with existing cardiovascular risk factors.25 Overall, however, research in this area is mixed, with at least one retrospective cohort analysis finding no significant association between statin use and increased risk for male sexual dysfunction.26-28 Supplementing with GG as raw material or cofactor for hormone synthesis has potential to ameliorate the negative effects of statins on testosterone levels. GG has been shown to increase production of both testosterone and progesterone in murine Leydig tumor cells.29 Rats supplemented with vitamin K2 MK-4 (the synthesis of which requires GG) showed increased plasma and testicular levels of testosterone. MK-4 may be involved in testosterone synthesis in the testes, leading researchers to speculate that supplementation may positively impact the natural decline in this hormone during aging.30,31 Vitamin K1 was not shown to have this effect, suggesting that K2—specifically, MK-4—is needed for this process.

BLOOD SUGAR REGULATION AND METABOLIC HEALTH Decreased synthesis of GG and other compounds produced via the mevalonate pathway may contribute to the increased risk for new-onset type 2 diabetes noted among statin users.32-34 The US FDA acknowledges the potential for increased blood sugar and HbA1c among those who take statins,35 a phenomenon that may result in part from decreased insulin secretion.36 A possible contributing mechanism is statins’ inhibition of protein prenylation, a protein modification step required for glucose-stimulated release of insulin from pancreatic beta cells.37-39 Researchers have noted that this may be due to statins reducing synthesis of metabolites in the mevalonate pathway, which would include GG.33,40 For individuals who require the cholesterol-lowering effect of statins, providing exogenous GG may help mitigate this risk while still favorably affecting blood lipids. It was shown in human monocytes in vitro that

50

GG exerts its beneficial effects without interfering with the cholesterol-lowering properties of statins,16 and researchers have written that GG “may be a potential drug for the prevention or treatment of statin-induced diabetes without interfering with the beneficial plasma cholesterol-lowering effects of statin.”41 Beyond the potential for GG to mitigate the effects of statins on blood glucose, GG may also aid in blood sugar regulation by inducing PPARγ expression and enhancing the biological effects of PPARγ agonist medications, such as the thiazolidinediones (TZDs) used to treat type 2 diabetes.41 This was shown in mouse adipocytes and human hepatocytes.42

PAIN REDUCTION Pain relief is another area where GG is promising as a therapeutic agent. Brazilian folk medicine has traditionally employed seeds from the plant Pterodon pubescens Benth (also called sucupira branca) for their medicinal properties. Modern laboratory assays have determined this plant to be a source of GG, and these extracts have been shown to be anti-inflammatory, analgesic, musclerelaxing, anti-rheumatic and hypoglycemic.43-45 Rodent models employing oral administration of GG show that the analgesic effects can take place as quickly as within minutes (for immediate pain relief and reduction of pain from skin burn, heat burn and gastritis). Anti-nociceptive effects for edema and pressure pain took hours, and pain reduction for rheumatoid arthritis was observed within 2 weeks.45-47 Geranylgeraniol is critical for supporting cardiometabolic health and graceful aging. Future human research may elucidate additional clinical applications for this compound and expand its potential therapeutic roles.

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Primer on Geranylgeraniol

REFERENCES 1.

Baker SK, Tarnopolsky MA. Statin-associated neuromyotoxicity. Timely Top Med Cardiovasc Dis. 2005 Sep 1;9:E26.

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Marshall TM. New Insights into the Statin-Cholesterol Controversy. Journal of American Physicians and Surgeons Vol 19 No 2. Summer 2014.

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Okuyama H, Langsjoen PH, Hamazaki T, Ogushi Y et al. Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Rev Clin Pharmacol. 2015 Mar;8(2):18999.

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Jaśkiewicz A, Pająk B, Litwiniuk A, Urbańska K, Orzechowski A. Geranylgeraniol Prevents Statin-Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy. Oxid Med Cell Longev. 2018;2018:6463807. Published 2018 May 21.

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Cao P, Hanai J, Tanksale P, Imamura S, Sukhatme VP, Lecker SH. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J. 2009;23(9):2844–2854.

30. Ito A, Shirakawa H, Takumi N, et al. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011;10:158. Published 2011 Sep 13. doi:10.1186/1476-511X-10-158.

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Hederstedt L. Heme A biosynthesis. Biochim Biophys Acta. 2012 Jun;1817(6):920-7.

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Pabst AM, Krüger M, Sagheb K, Ziebart T et al. The influence of geranylgeraniol on microvessel sprouting after bisphosphonate substitution in an in vitro 3D-angiogenesis assay.

Clin Oral Investig. 2017 Apr;21(3):771-778.

31. Ho HJ, Shirakawa H, Giriwono PE, Ito A, Komai M. A novel function of geranylgeraniol in regulating testosterone production. Biosci Biotechnol Biochem. 2018 Jun;82(6):956-962. doi: 10.1080/09168451.2017.1415129.

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Cranenburg EC, Schurgers LJ, Vermeer C. Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost. 2007 Jul;98(1):120-5.

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Flore R, Ponziani FR, Di Rienzo TA, Zocco MA et al. Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. Eur Rev Med Pharmacol Sci. 2013 Sep;17(18):2433-40.

10. Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Integr Med (Encinitas). 2015;14(1):34–39.

11. Palermo A, Tuccinardi D, D’Onofrio L, Watanabe M et al. Vitamin K and osteoporosis: Myth or reality? Metabolism. 2017 May;70:57-71.

12. Vermeer C, Raes J, van ‘t Hoofd C, Knapen MHJ, Xanthoulea S. Menaquinone Content of Cheese. Nutrients. 2018;10(4):446.

13. Schwalfenberg GK. Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health. J Nutr Metab. 2017;2017:6254836.

14. Hirota Y, Nakagawa K, Sawada N, et al. Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1. PLoS One. 2015;10(4):e0125737.

15. Marcuzzi A, Piscianz E, Zweyer M, et al. Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. Int J Mol Sci. 2016;17(3):365.

16. Campia I, Lussiana C, Pescarmona G, Ghigo D, Bosia A, Riganti C. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. Br J Pharmacol. 2009;158(7):1777–1786.

17. Pabst AM, Krüger M, Blatt S, et al. Angiogenesis in the Development of Medication-Related Osteonecrosis of the Jaws: An Overview. Dent J (Basel). 2016;5(1):2.

18. Ziebart T, Koch F, Klein MO, Guth J et al. Geranylgeraniol - a new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw. Oral Oncol. 2011 Mar;47(3):195-201.

19. Zafar S, Coates DE, Cullinan MP, Drummond BK et al. Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts. Clin Oral Investig. 2016 Nov;20(8):2023-2035.

20. Williams C, Johnson B, Svrcina H, Kawsky B, Jones D. Use of geranylgeraniol to rescue osteoblasts and periodontal ligament fibroblasts from zoledronate-induced apoptosis (663.16).

The FASEB Journal. Pharmacology and Experimental Therapeutics. April 2014.

21. Pabst AM, Krüger M, Ziebart T, Jacobs C et al. The influence of geranylgeraniol on human oral keratinocytes after bisphosphonate treatment: An in vitro study. J Craniomaxillofac Surg.

2015 Jun;43(5):688-95.

22. Schooling CM, Au Yeung SL, Freeman G, Cowling BJ. The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials. BMC Med. 2013;11:57. Published 2013 Feb 28. doi:10.1186/1741-7015-11-57.

23. de Graaf L, Brouwers AH, Diemont WL. Is decreased libido associated with the use of HMG-CoA-reductase inhibitors?. Br J Clin Pharmacol. 2004;58(3):326–328. doi:10.1111/ j.1365-2125.2004.02128.x.

24. Do C, Huyghe E, Lapeyre-Mestre M, Montastruc JL, Bagheri H. Statins and erectile dysfunction: results of a case/non-case study using the French Pharmacovigilance System Database. Drug Saf. 2009;32(7):591-7. doi: 10.2165/00002018-200932070-00005.

25. Solomon H, Samarasinghe YP, Feher MD, Man J et al. Erectile dysfunction and statin treatment in high cardiovascular risk patients. Int J Clin Pract. 2006 Feb;60(2):141-5. DOI: 10.1111/j.1742-1241.2006.00793.x.

26. Cai X, Tian Y, Wu T, Cao CX, Bu SY, Wang KJ. The role of statins in erectile dysfunction: a systematic review and meta-analysis. Asian J Androl. 2014;16(3):461–466. doi:10.4103/1008682X.123678.

27. Sniderman AD, Thanassoulis G. Do statins lower testosterone and does it matter?. BMC Med. 2013;11:58. Published 2013 Feb 28. doi:10.1186/1741-7015-11-58.

28. Davis R, Reveles KR, Ali SK, Mortensen EM, Frei CR, Mansi I. Statins and male sexual health: a retrospective cohort analysis. J Sex Med. 2015;12(1):158–167. doi:10.1111/ jsm.12745.

29. Ho HJ, Shirakawa H, Yoshida R, Ito A et al. Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells. Biosci Biotechnol Biochem. 2016;80(4):791-7. doi: 10.1080/09168451.2015.1123612.

32. Backes JM, Kostoff MD, Gibson CA, Ruisinger JF. Statin-Associated Diabetes Mellitus: Review and Clinical Guide. South Med J. 2016 Mar;109(3):167-73.

33. Brault M, Ray J, Gomez YH, Mantzoros CS, Daskalopoulou SS. Statin treatment and newonset diabetes: a review of proposed mechanisms. Metabolism. 2014 Jun;63(6):735-45.

34. Chrysant SG. New onset diabetes mellitus induced by statins: current evidence. Postgrad Med. 2017 May;129(4):430-435.

35. U.S. Food & Drug Administration. FDA Drug Safety Communication: Important safety label changes to cholesterol-lowering statin drugs. Issued Feb 28, 2012; accessed Aug 26, 2019 from https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communicationimportant-safety-label-changes-cholesterol-lowering-statin-drugs.

36. Cederberg H, Stančáková A, Yaluri N, Modi S, Kuusisto J, Laakso M. Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort. Diabetologia. 2015 May;58(5):1109-17.

37. Amin R, Chen HQ, Tannous M, Gibbs R, Kowluru A. Inhibition of glucose- and calciuminduced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation. J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.

38. Kowluru A, Amin R. Inhibitors of post-translational modifications of G-proteins as probes to study the pancreatic beta cell function: potential therapeutic implications. Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):129-39.

39. Kowluru A. Protein prenylation in glucose-induced insulin secretion from the pancreatic islet beta cell: a perspective. J Cell Mol Med. 2008;12(1):164–173.

40. Rizzo M, Spinas GA, Rini GB, Berneis K. Is diabetes the cost to pay for a greater cardiovascular prevention? Int J Cardiol. 2010 Oct 8;144(2):309-10.

41. Matsubara T, Takakura N, Urata M, et al. Geranylgeraniol Induces PPARγ Expression and Enhances the Biological Effects of a PPARγ Agonist in Adipocyte Lineage Cells. In Vivo. ;32(6):1339–1344.

42. Takahashi N, Kawada T, Goto T, Yamamoto T et al. Dual action of isoprenols from herbal medicines on both PPARgamma and PPARalpha in 3T3-L1 adipocytes and HepG2 hepatocytes. FEBS Lett. 2002 Mar 13;514(2-3):315-22.

43. Nucci C, Mazzardo-Martins L, Stramosk J, Brethanha LC et al. Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain. J Ethnopharmacol. 2012 Aug 30;143(1):170-8. doi: 10.1016/j.jep.2012.06.020.

44. Hoscheid J, Cardoso ML. Sucupira as a Potential Plant for Arthritis Treatment and Other Diseases. Arthritis. 2015;2015:379459. doi:10.1155/2015/379459.

45. Grando, Rogerio & H. Souza, Vanessa & M. Monteiro, Karin & Oliveira Sousa, Ilza & Queiroz, Núbia & E. Carvalho, João & M. Spindola, Humberto & Foglio, Mary. (2016).

Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Benth.

Fruit Extracts on Antinociceptive and Anti-Inflammatory Activity. Journal of the Brazilian Chemical Society. 28. 10.21577/0103-5053.20160281.

46. Spindola HM1, Servat L, Rodrigues RA, Sousa IM et al. Geranylgeraniol and 6α,7βdihydroxyvouacapan-17β-oate methyl ester isolated from Pterodon pubescens Benth.: Further investigation on the antinociceptive mechanisms of action. Eur J Pharmacol. 2011 Apr 10;656(1-3):45-51. doi: 10.1016/j.ejphar.2011.01.025.

47. Spindola HM, Servat L, Denny C, et al. Antinociceptive effect of geranylgeraniol and 6alpha,7beta-dihydroxyvouacapan-17beta-oate methyl ester isolated from Pterodon pubescens Benth. BMC Pharmacol. 2010;10:1. Published 2010 Jan 7. doi:10.1186/1471-2210-10-1.

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51

CHANGING THE AGE GAME

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Geranylgeraniol (GG) is a compound present in all living cells and is an essential molecule for numerous biological processes affecting organs and tissues throughout the body.*

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As GG is required for protein synthesis, increasing the supply of GG may help support muscle health and preservation.*

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GG is required for cellular health including cellular growth, differentiation, survival, and apoptosis.*

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Hormones

GG ensures calcium deposits into the bones and teeth instead of other tissues where these deposits can cause issues in the blood vessels and joints.*

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Aging and the Gut Microbiome By: Kasey Hutchinson, RDN The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

As humans, we come from different backgrounds, have different physical features, and follow many different career paths, but one thing that connects us all is the process of aging.

Aging goes beyond the physical signs, like graying hair and wrinkled skin, and affects mental acuity, physical vigor, disease susceptibility, and energy levels. Since antiquity, humans have searched for the magical elixir that will prevent the natural decline of youth. However, it appears that the secret to anti-aging starts within.

New research shows that gut health is a key determinant of longevity.

THE IMPORTANCE OF GUT HEALTH The intestines are much more than a site of digestion and absorption of food. They are also home to trillions of microorganisms, known as the gut microbiome, which has coevolved with the human body over the past 500 million years. In this symbiotic relationship, the human host provides food and a place to stay, while the microbes produce hormones, neurotransmitters, anti-inflammatory molecules, digestive enzymes, and more (1). This recently-defined ecosystem is vital to building a strong immune system, cultivating mental health, and keeping inflammation at

56

bay. Interestingly, the composition of gut microbes changes as we age, and this affects numerous mechanisms associated with advanced age.

GUT MICROBE COMPOSITION CHANGES WITH AGE As infants, the human gut is first colonized by the motherâ&#x20AC;&#x2122;s vaginal microbiome, breast milk, and the environment. Thus, the infant microbiome is typically dominated by the genus Bifidobacterium and Lactobacillus as well as members of the Enterobacteriaceae family (2). These bacteria assist with the biological needs of this age, such as lactose digestion and immune system development. During adolescence and adulthood, the microbial diversity increases significantly, marked by a bloom of Bacillus, Faecalibacterium, Clostridium, and many more (3).

However, in the GI tract of elderly individuals, there is a substantial decrease in overall diversity and abundance of gut bacteria. Adults over the age of 70 show an increase in disease-promoting species, such as C. perfringens and C. difficile, while Lactobacilli and Bifidobacteria colonies plummet (4). Converse to this general trend, researchers have discovered that in areas of

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Aging and the Gut Microbiome

the world where people frequently live to be more than 100 years old, i.e. centenarian populations, there is actually a spike in microbial diversity associated with old age. A recent study from the journal Current Biology examined the microbial composition among 24 elderly people aged 104-109. Results indicated that these super-centenarians had increased abundance of Akkermansia, Bifidobacterium, and Christensenellaceae, a much different profile than frail elderly individuals (5). This has led to strong speculations that gut microbes may be the key to extreme longevity and a closer look into individual functions of bacterial strains offers further evidence for this claim.

THE VARIOUS ROLES OF BENEFICIAL BACTERIA Each strain of gut bacteria appears to have specific functions in the body, with some of them overlapping tasks providing an important redundancy. For example, Christensenellaceae is part of the microbial signature of extremely longevous people and is also associated with lean body mass and reduced risk of chronic disease (6).

Interestingly, the abundance of Christensenellaceae bacteria appears to be influenced by host genetics, suggesting that longevity also contains a heritable component that influences gut microbial populations.

Bifidobacteria ferment dietary fiber and produce powerful fermentation by-products known as shortchain fatty acids (SCFA) (7). These molecules perform various functions in the body such free-radical scavenging and other anti-inflammatory tasks, the development and maintenance of the immune system, and more. In fact, a recent study reported that SCFAs assist the hormone signaling involved in bone density, suggesting that these strains can ameliorate factors of osteoporosis. Furthermore, Bifidobacteria protect against DNA damage and oxidative stress while aiding in the detoxification of carcinogens (8).

Faecalibacterium prausnitzii and Akkermansia muciniphila help prevent the invasion of pathogens and harmful molecules involved with the onset of disease, also known as leaky gut syndrome (9). A. muciniphila also regulates various aspects of metabolism and fights gut inflammation. In fact, A. muciniphila is touted by researchers as an effective anti-aging microbe because it is so beneficial at reversing the agerelated decline in the gut mucosa (10). The combined

effects of these beneficial microbes can increase lifespan and quality of life in aging populations.

GUT BARRIER FUNCTION AND AGING he gut barrier is a single layer of epithelial tissue covered with a viscous mucosal layer that separates the intestinal contents from the rest of the body (1). This area allows nutrients to enter the body but protects against the invasion of pathogenic bacteria and deleterious chemical compounds. Overuse of broad-spectrum antibiotics, hyper-sanitized environments, poor diets, and stress can damage this layer, leaving holes in this shield. Lipopolysaccharide (LPS) is one of the most prevalent and damaging molecules that can leak through a weakened gut barrier. LPS is a component of bacterial cell membranes and is normally benign if it remains within the gut, where it is eventually excreted in the feces (10). However, if it enters circulation, an inflammatory cascade can lead to fibrosis and cell death anywhere in the body. This is one of the underlying factors involved in the pathogenesis of Alzheimer’s disease, cancer, diabetes, prematurely aging skin, chronic pain, and mental decline (1). Research continues to highlight the harmful effects of inflammation on the progression of aging. In fact, a new word has even been developed to describe this relationship: inflammaging.

According to a recent report, “inflammaging refers to the chronic, low-grade inflammation that characterizes aging.” This process can involve nearly every organ of the body, including the microbiome, and is characterized by an imbalance of inflammatory actions (11).

Mechanisms behind inflammaging include increased intestinal permeability, gut dysbiosis, oxidative stress caused by dysfunctional mitochondria, and immune dysregulation (12). Numerous studies report the association between gut microbiome alterations and increased frailty in the elderly (13,14). However, it seems to be a question of the chicken versus the egg as to which event takes place first. Scientists are currently diving into research to find the answer.

In a recent study published in Frontiers in Microbiology researchers took fecal matter from old mice (experiencing inflammaging) and young mice and transferred it to the GI tract of germ-free mice (15). Within 4 weeks of this transfer, the GF mice receiving fecal transfer from older mice had an upsurge of TNF-a production, TLR-4 activation,

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Aging and the Gut Microbiome

increased gut permeability, increased abundance of Proteobacteria, and reduced abundance of Akkermansia muciniphila. The authors of this study suggest that gut microbiota composition in aged individuals contributes to the inflammaging process. Furthermore, they recommend that health care professionals â&#x20AC;&#x153;consider ways to modify gut microbiota composition of the elderly,â&#x20AC;? perhaps using probiotics or prebiotics.

While it is designed to protect the body from infection and disease, inflammation can turn into a chronic condition that creates oxidative damage, especially when LPS is present. This is the underlying source of wrinkles, vision loss, cancer, and several other diseases plaguing this nation. In fact, LPS-induced low-grade inflammation, also known as metabolic endotoxemia, has recently been found to alter telomere length, which could shorten lifespan.

TELOMERES AND INFLAMMATION Telomeres act as a molecular clock of the cells.

Near the terminal end of chromosomes exists complex heterochromatin structures that protect the chromosome and preserve the genome (16). Through the process of cellular division, parts of this structure are lost, and eventually the telomere reaches critical length, initiating apoptosis or replicative senescence.

Replicative senescence can be thought of as the permanent inhibition of cellular growth and division and is observed in many cells throughout the body (17). Senescent cells have shortened telomeres, yet are impervious to apoptosis and have no telomerase activity.

In immature cells, lymphocytes, and other cells during gestation, telomeres are elongated by an enzyme known as telomerase. This fascinating enzyme is not present in most mature cells, which is why many of them eventually die. Thus, telomerase and telomere length have become hot topics regarding anti-aging. A recent murine study published in the journal Nature Communications found that chronic low-grade inflammation induces reactive oxygen species, leading to the activation of NF-kB pathways in mice (18). This process prompted telomere dysfunction and premature aging in the mice.

LPS attaches to pattern recognition receptors, such as toll-like receptor-4, initiating a cascade of inflammatory responses. This leads to an influx of

58

inflammatory cytokines which disrupt telomerase activity and may progress to cellular senescence (19).

According to the most current scientific reports, it is imperative to follow a healthy lifestyle including the avoidance of smoking, consuming a healthy, balanced diet, managing stress, and maintaining a healthy gut microbiome. Healing the intestinal mucosal layer and promoting the growth of beneficial gut bacteria have a massive and positive influence on reducing metabolic endotoxemia and systemic inflammation.

A recent study published in the World Journal of Gastrointestinal Pathophysiology found that a novel probiotic supplement, containing 5 strains of Bacillus spores, significantly improves symptoms of metabolic endotoxemia (20). Researchers recruited 26 healthy men and women and randomly divided them into 2 groups.

The control group received a placebo pill containing rice flour, while the experiment group received a commercial spore-based probiotic supplement containing Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, Bacillus licheniformis, and Bacillus clausii.

Researchers stimulated LPS-induced metabolic endotoxemia in participants using a high-fat, heavily processed meal both at the beginning and end of the 30-day trial. Circulating LPS and inflammatory cytokine levels were measured. At the end of the experiment, the experiment group had a 42% reduction in circulating LPS levels as well as reduced inflammatory cytokine production following the high fat meal. Conversely, the control group experienced a 35% increase in LPS levels.

This study underscores the potential of probiotic therapy to reduce total body inflammation, which could have massive and positive impacts on preserving telomere length and reducing incidence of age-related disease.

Aging is a natural and inevitable process that happens to everyone, regardless of status, income, or geographic location, but gut health seems to determine the impact and severity of the aging process. Certain gut microbes appear to play a central role in reducing inflammaging and enhancing longevity. Furthermore, a robust gut mucosa can prevent harmful molecules from entering the body and causing inflammation and damage to telomeres. Thus, maintaining a healthy and diverse gut microbiome has the potential to promote a smooth aging process. Health professionals are encouraged to use probiotics, prebiotics, and other lifestyle and diet techniques to best modulate the gut microbiome.

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

Aging and the Gut Microbiome

REFERENCES 1.

Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin Gastroenterol. 2015;31(1):69–75. doi:10.1097/ MOG.0000000000000139

11. Franceschi et al. Inflammaging and Gargaging. Trends in Endocrinology and Metabolism. 2017; 28: (3) 199-212. DOI: https://doi.org/10.1016/j. tem.2016.09.005.

2.

Stewart C, et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature Reviews. 2018; 562: 583–588. doi:/10.1038/s41586-018-0617-x

12. Ferrucci, et al. Inflammageing: chronic inflammation in ageing, cardiovascular disease and frailty. Nature Reviews. 2018; 15: 505-523.

3.

Rinninella E, Raoul P, Cintoni M, et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019;7(1):14. Published 2019 Jan 10. doi:10.3390/microorganisms7010014

4.

Nagpal R, Mainali R, Ahmadi S, et al. Gut microbiome and aging: Physiological and mechanistic insights. Nutr Healthy Aging. 2018;4(4):267– 285. Published 2018 Jun 15. doi:10.3233/NHA-170030.

5.

Biagi et al. Gut Microbiota and Extreme Longevity. Current Biology.

2016;26:1480–1485. DOI: 10.1016/j.cub.2016.04.016

6.

Goodrich JK, Waters JL, Poole AC, et al. Human genetics shape the gut microbiome. Cell. 2014;159(4):789–799. doi:10.1016/j.cell.2014.09.053

7.

Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front Microbiol. 2016;7:979. Published 2016 Jun 28. doi:10.3389/fmicb.2016.00979

8.

9.

Oberreuther-Moschner DL, et al. Dietary intervention with the probiotics Lactobacillus acidophilus 145 and Bifidobacterium longum 913 modulates the potential of human faecal water to induce damage in HT29clone19A cells. Br J Nutr. 2004;91(6):925-32. DOI: 10.1079/BJN20041108 Odamaki T, Kato K, Sugahara H, et al. Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. BMC Microbiol. 2016;16:90. Published 2016 May 25. doi:10.1186/ s12866-016-0708-5

10. van der Lugt B, van Beek AA, Aalvink S, et al. Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1-/∆7 mice. Immun Ageing. 2019;16:6. Published 2019 Mar 8. doi:10.1186/s12979-019-0145-z.

13. O’Toole et al. Gut microbiota and aging. Science. 2015; 350:(6265) 12141215. DOI: 10.1126/science.aac8469 14. Mello et al. Gastrointestinal Microbiota and Their Contribution to Healthy Aging. Dig Dis. 2016; 34(3): 194-201. DOI: 10.1159/000443350.

15. Fransen F, van Beek AA, Borghuis T, et al. Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice. Front Immunol. 2017;8:1385. Published 2017 Nov 2. doi:10.3389/ fimmu.2017.01385 16. Kordinas V, Ioannidis A, Chatzipanagiotou S. The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?. Genes (Basel).

2016;7(9):60. Published 2016 Sep 3. doi:10.3390/genes7090060.

17. Zhang J, et al. Ageing and the Telomere Connection: An Intimate Relationship with Inflammation. Ageing Res Rev. 2016;25:55-69. DOI: 10.1016/j.arr.2015.11.006.

18. Jurk D, Wilson C, Passos JF, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014;2:4172.

DOI:10.1038/ncomms517 19. Jose SS, Bendickova K, Kepak T, Krenova Z, Fric J. Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex? Frontiers in Immunology. 2017;8. doi:10.3389/ fimmu.2017.01078.

20. McFarlin BK, Henning AL, Bowman EM, Gary MA, Carbajal KM. Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers. World J Gastrointest Pathophysiol. 2017;8(3):117–126. doi:10.4291/wjgp.v8.i3.117

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INTRODUCTION Coenzyme Q10 (CoQ10) is a small lipophilic structure composed of a benzoquinone ring and an isoprenoid side-chain1,2. First described in 1955, named ubiquitous quinone, CoQ10 is located ubiquitously in cell membranes1,2. It was not until 1957 where its function as an electron carrier in the mitochondrial electron transport chain was reported in bovine heart mitochondria1,2. Synthesis of CoQ10 in humans occurs in the membrane of the mitochondrial matrix via a collection of enzymes (complex Q)1,2. The benzoquinone ring is derived from 4-hydrobenzoic acid, while the ten isoprenes are derived from mevalonic acid from the cholesterol synthesis pathway1,2. It is the quinone ring that is responsible for carrying electrons to Complex III1,2.

CoQ10 is distributed in all membranes of cells and forms a crucial component of the electron transport chain (ETC) transporting electrons between Complex I/II and III1,2. CoQ10 accepts electrons from the different donors (e.g. Complex I, Complex II)1,2. Through accepting electrons, CoQ10 cycles between

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three chemical forms: completely oxidised (ubiquinone), semioxidised intermediate free radical (semiquinone) and a completely reduced form (ubiquinol)(Figure 1)1–3. It is with the movement within the mitochondrial membrane that allows the pumping of protons at Complex III. This helps generate adenosine triphosphate (ATP)1,2.

Because of this function, tissues with higher mitochondrial content and therefore metabolic rate (for example heart, kidney, liver and muscle), have high levels of CoQ101,2.

In addition to its main function in the ETC, CoQ10 has a critical antioxidant role1,2. This helps stabilize the plasma membrane and protect membrane phospholipids from peroxidation1,2. Because of this, diminished levels in aging likely contribute to membrane peroxidation injury1,2. Ubiquinone and semiquinone are also involved in reducing α-tocopherol and ascorbate helping with redox balance in the cell1,2. Recent publications have also shown that CoQ10 can play a role in apoptosis and have antiatherogenic effects as well1,2,4.

ANTI - AGING MEDICAL NEWS • WINTER 2019

Coenzyme Q10 and Aging

Figure 1: Redox forms of CoQ10. Adapted from de Barcelos & Haas 2019

COQ10 & AGING Aging is a part of life. It is a multifactorial process that involves numerous environmental and genetic factors5. A common theory that explains the association between age and degenerative disease is oxidative imbalance1,2,5. This is where the production of antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and CoQ10 are not able to contain the production of reactive oxygen species (ROS)1,2,5. This leads to oxidative stress. In many diseases and disorders, this increase of ROS decreases CoQ10 levels in the human body1,2,5. This deficiency leads to mitochondrial dysfunction decreasing the efficiency of cells1,2,5. Therefore, CoQ10 is essential for the health of many human tissues and CoQ10 supplementation has been proposed to help alleviate the effects of aging1,2,5.

The majority of CoQ10 comes from internal synthesis but is widely found in many animal protein sources, vegetables, fruits and cereals1,2,5,6. While consuming CoQ10 externally increases plasma levels, supplementation may not increase tissue levels of CoQ10 in normal tissues which is not ideal1,2,5.

Although certain studies have shown that tissue uptake does occur in a variety of human diseases.

COQ10 SUPPLEMENTATION IN THE TREATMENT OF HUMAN DISEASES CoQ10 has been used in numerous studies looking at human pathologies and disorders. Many studies have tested the safety and efficacy of CoQ10.

There have been reports that 1200mg daily dose of CoQ10 supplementation was safe in a randomized controlled human trial2. However, Hathcock and Shao demonstrated that doses as high as 3000mg

per day in shorter clinical trials was safe too7. Even though studies have their own limitations, CoQ10 can be considered an important part in the treatment of a range of chronic diseases that primarily affect the aged, some of which will be discussed below.

Heart failure and increased ROS have a well-documented association1,2,5. The increase in ROS can be due to decreased levels of endogenous antioxidants1,2,5. Flowers et al. performed a systematic review on the efficacy of CoQ10 supplementation in the prevention of cardiovascular disease (CVD) without any changes to lifestyle8. The results indicated a significant reduction in systolic blood pressure but none of the other CVD risk factors such as total cholesterol, or diastolic blood pressure were affected8. A second meta-analysis investigated the impact of CoQ10 in reducing complications in cardiac surgery patients9. Results showed that CoQ10 therapy decreased the need of inotropic drugs and reduced the appearance of ventricular arrhythmias after surgery9.

Due to its antioxidant properties, CoQ10 supplementation has been proposed for the treatment of metabolic syndrome and type 2 diabetes2. However, results have been mixed. Moradi et al. showed that CoQ10 therapy had mild effects in type 2 diabetic patients10. CoQ10 was seen to reduce fasting glucose levels in the plasma without making changes in fasting insulin and glycated haemoglobin10. Despite that, numerous other trials have shown no significant effects on blood sugar control, lipid profile or blood pressure in diabetic patients. However, a reduction in triglycerides in serum was noted2. While this research does show some promise, more research needs to be done to see if CoQ10 can indeed help to treat metabolic diseases.

As with cardiometabolic disease, there is a wellestablished correlation between mitochondrial dysfunction and neurodegenerative diseases. Studies

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Coenzyme Q10 and Aging

show that CoQ10 can preserve mitochondrial function and help reduce dopaminergic neuron loss in Parkinsonâ&#x20AC;&#x2122;s disease2. A recent systematic review was conducted to evaluate the impact of CoQ10 supplementation on the frequency, severity and duration of the migraine attacks11. Four randomized clinical trials with 221 participants were included11. The review suggested that CoQ10 may reduce the frequency of migraine attacks per month but does not affect the severity or duration of the attacks11. A trial has also been registered with the Australia and New Zealand Clinical Trials Registry (ANZCTRN12618001841268) to investigate the efficacy of Ubiquinol as a treatment for age-related cognitive decline that could impact productivity and quality of life within healthy, elderly patients12. This study would be valuable for health care practitioners and the general community and whether the advantages of CoQ10 treatment outweighs the disadvantages.

MITOCHONDRIAL - TARGETED COQ10 It is very important to keep our antioxidants levels at a high level especially with CoQ1013,14. Due to its low oral bioavailability and the lack of ability to get into the mitochondria, various structural modifications have been made to supplemental CoQ10 to improve distribution of this antioxidant to the mitochondria.

One of which is mitoquinol15. Mitoquinol contains a triphenylphosphonium ion fused to a ubiquinone group (the active antioxidant component of CoQ10) through a lipophilic hydrocarbon chain15. It was found that a 10-atom carbon chain enabled optimal absorption and interaction with the inner membrane of the mitochondria. Additional research suggests mitoquinol may have beneficial effects on many of the regulatory processes that mitochondria influence15.

According to a 2016 report by the World Health Organization (WHO), cardiovascular diseases (CVDs) represent the top 2 leading causes of global death16. Age-related changes in vasculature caused by oxidative stress were postulated to be the main factors for the development of CVD17. A previous report had demonstrated that oral supplementation of mitoquinol restored endothelium-dependent dilation in murine models. In 2018, Rossman et al.

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conducted the first randomized, double-blind, placebocontrolled clinical trial using mitoquinol in healthy middle-aged and older adults to identify its effects on the vasculature17. Mitoquinol was deemed safe and well-tolerated17. Brachial artery flow mediated dilation (a method to analyse endothelial function) was 42% higher in patients who were administered mitoquinol due to the inhibition of mitochondrial ROS17. In addition, oxidized LDL (a circulating biomarker for oxidative stress) and aortic stiffness were both lowered 6 weeks post-administration17.

Separately, Johnson and Grant performed two blinded, placebo-controlled studies to investigate how mitoquinol can affect symptoms seen in fibromyalgia, myalgic encephalomyelitis and chronic fatigue18. After treatment with mitoquinol, the parallel analysis group of fibromyalgia patients had a significant decrease in pain and increased working memory, while sleep quality was increased in both18. When analysing the fibromyalgia crossover (all the data was collected and replaces missing values with estimates derived from multiple imputation), values were very consistent18. Pain and working memory improvements were statistically significant18. Both groups showed modest increases in energy and activity.

Verbal reasoning also increased in both groups18.

Recently a paper published in 2019 reported that mitoquinol could has a protective effect on cigarette smoke exposure on human umbilical vein endothelial cells19. Chen et al. demonstrated that mitoquinol had the ability to restore endothelial barrier integrity as well as decreased inflammation19. By reducing the production of ROS and overactivity of autophagy, mitoquinol also maintained mitochondrial function and protected against the cytotoxicity of cigarette smoke exposure19. Through this study, it was demonstrated that damage to mitochondria is a key driver in the dysfunction of the endothelial barrier, and of inflammation caused by exposure to cigarette smoke19.

Taken together, findings suggest mitochondrial-targeted antioxidants such as mitoquinol could be a promising treatment for CVDs, and other age-related diseases and disorders. Additional research is needed to address knowledge gaps and to determine the translatability of animal models for clinical development.

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

Coenzyme Q10 and Aging

CONCLUSIONS As our knowledge of mitochondria expand, important components inside these organelles have also been identified. One of which is the co-enzyme, CoQ10.

CoQ10 was once thought of as a dual functioning coenzyme, helping transport electrons into the electron transport chain and as an antioxidant to maintain redox balance. Much like the mitochondria, CoQ10 has been since been identified as a factor in many other processes in the body. Therefore, a decrease in CoQ10 levels

with age is potentially a significant contributor to the population health burden. While CoQ10 supplements are a great idea in theory, due to their low bioavailability, mitochondrial-targeted antioxidants are a significant advancement in this field. With more and more interest in CoQ10 supplementation, research will follow with the hopes of investigating whether it can be used to treat multiple systems in the body at once, or if it better suited to systems that contain a high density of mitochondria.

REFERENCES 1.

Barcelos IP de, Haas RH. CoQ10 and Aging. Biology. 2019;8(2):28. doi:10.3390/biology8020028

2.

Hernรกndez-Camacho JD, Bernier M, Lรณpez-Lluch G, Navas P. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol. 2018;9. doi:10.3389/fphys.2018.00044

3.

Mehrabani S, Askari G, Miraghajani M, Tavakoly R, Arab A. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies. Complement Ther Med. 2019;43:181-187. doi:10.1016/j.ctim.2019.01.022

4.

Vafa M. Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor- and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. June 2019:104290. doi:10.1016/j.phrs.2019.104290

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Saini R. Coenzyme Q10: The essential nutrient. J Pharm Bioallied Sci. 2011;3(3):466-467. doi:10.4103/0975-7406.84471

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Mortensen AL, Rosenfeldt F, Filipiak KJ. Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial. Cardiol J. 2019;26(2):147-156. doi:10.5603/CJ.a2019.0022

7.

Hathcock JN, Shao A. Risk assessment for coenzyme Q10 (Ubiquinone).

Regul Toxicol Pharmacol. 2006;45(3):282-288. doi:10.1016/j. yrtph.2006.05.006

8.

Flowers N, Hartley L, Todkill D, Stranges S, Rees K. Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.

Cochrane Database Syst Rev. 2014;(12):CD010405. doi:10.1002/14651858.

CD010405.pub2

9.

de Frutos F, Gea A, Hernandez-Estefania R, Rabago G. Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis.

Interact Cardiovasc Thorac Surg. 2015;20(2):254-259. doi:10.1093/icvts/ ivu334

10. Moradi M, Haghighatdoost F, Feizi A, Larijani B, Azadbakht L. Effect of Coenzyme Q10 Supplementation on Diabetes Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials. Arch Iran Med. 2016;19(8):588-596. doi:0161908/AIM.0012

11. Parohan M, Sarraf P, Javanbakht MH, Ranji-Burachaloo S, Djalali M. Effect of coenzyme Q10 supplementation on clinical features of migraine: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Neurosci. February 2019:1-8. doi:10.1080/10284 15X.2019.1572940 12. Stough C, Nankivell M, Camfield DA, et al. CoQ10 and Cognition a Review and Study Protocol for a 90-Day Randomized Controlled Trial Investigating the Cognitive Effects of Ubiquinol in the Healthy Elderly.

Front Aging Neurosci. 2019;11. doi:10.3389/fnagi.2019.00103 13. Zaki NM. Strategies for oral delivery and mitochondrial targeting of CoQ10. Drug Deliv. 2016;23(6):1868-1881. doi:10.3109/10717544.2014.99 3747 14. Kelso GF, Porteous CM, Coulter CV, et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem. 2001;276(7):4588-4596. doi:10.1074/ jbc.M009093200 15. Murphy MP. Targeting lipophilic cations to mitochondria. Biochim Biophys Acta BBA - Bioenerg. 2008;1777(7):1028-1031. doi:10.1016/j. bbabio.2008.03.029 16. The top 10 causes of death. https://www.who.int/news-room/fact-sheets/ detail/the-top-10-causes-of-death. Published May 24, 2018. Accessed September 20, 2019.

17. Rossman MJ, Santos-Parker JR, Steward CAC, et al. Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults. Hypertens Dallas Tex 1979.

2018;71(6):1056-1063. doi:10.1161/HYPERTENSIONAHA.117.10787 18. Johnson C, Grant J. The Influence of Mitoq on Symptoms and Cognition in Fibromyalgia, Myalgic Encephalomyelitis and Chronic Fatigue.; 2016. doi:10.13140/RG.2.1.2329.8805 19. Chen S, Wang Y, Zhang H, et al. The Antioxidant MitoQ Protects Against CSE-Induced Endothelial Barrier Injury and Inflammation by Inhibiting ROS and Autophagy in Human Umbilical Vein Endothelial Cells. Int J Biol Sci. 2019;15(7):1440-1451. doi:10.7150/ijbs.30193

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ANTI - AGING MEDICAL NEWS • WINTER 2019

Dentalcidin LS Oral Care Solution Booth #7021

Leaky mouth can have the same implications as “leaky gut” in terms of inflammatory conditions, including heart disease. Dentalcidin™LS Liposomal Oral Care Solution can assist in removing pathogenic biofilms and plaque, and is an excellent way to promote and maintain healthy teeth and gums.

Dentalcidin™LS contains broad-spectrum botanicals and essential oils, including clove and myrrh, as well as CoQ10 and Quercetin. Research indicates results in as little as 4-8 weeks of use.

Bio-Botanical Research, Inc. | Ph: (800) 775-4140 | www.biocidin.com

Pros-Tech Ultra Booth #4043

Pros-Tech Ultra is a unique combination of ingredients formulated to support prostate, urinary, and male reproductive health.

Bio-Tech Pharmacal | Ph: (888) 906-4304 | www.biotechpharmacal.com

Alpha-Theta Ultra PM

Booth #6013

Biotics Research Corporation introduces Alpha-Theta Ultra PM™! It is estimated that sleep-related problems affect 50 to 70 million Americans of all ages and socioeconomic classes. Good quality, uninterrupted sleep is integral to achieving optimal health. Alpha-Theta Ultra PM™ induces calming brainwave activity, improves overall sleep onset, quality and duration, promotes natural circadian rhythms, supports healthy levels of GABA, serotonin and dopamine, fosters GABA receptor function, protects against glutamate toxicity, and optimizes stress response.

Biotics Research Corporation | Ph: (800) 231-5777 | www.bioticsresearch.com

The Blu Room Booth #4085

What is the value for a clinician? The Blu Room is an adjunct to medical treatment that helps patients in despair be uplifted, those in pain be relieved, those depressed and stressed be transformed into a tranquil peaceful state of being. The Blu Room atmosphere supports physical, emotional, and spiritual wellbeing in our patients’ healing journey. That is closest to the idealistic calling of healing that medicine is all about. Come try it for yourself!

Blu Room Enterprises, LLC | Ph: (360) 458-5230 | www.bluroom.com

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ANNOUNCEMENTS BioSkinMD Booth #4026

BioSkinMD is a clean beauty, medical-grade skincare line formulated by pharmacists and physicians to address the signs of aging and help create healthy, younger looking skin without the use of common ingredients linked to harmful health effects and skin irritations. BioSkinMD products are formulated without parabens, phthalates, sulfates, silicones or synthetic fragrances using an advanced pharmaceutical-grade delivery system to help ensure effective penetration into the skin.

BodyLogicMD | Ph: 561-425-9912 www./shop.bodylogicmd.com/products/bioskinmd-skincare-kit

Medical Celebrity & Authority Positioning with Dr. Oz Booth #5097

Your patients will attribute more authority, credibility, status & success to you and your Practice with Clint Arthur’s FAST & EASY solution for Medical professionals to be viewed as a “Celebrity Expert.”

Celebrity Entrepreneur | Ph: (212) 888-2999 | www.clintarthur.tv

AuroGSH - Topical Glutathione (patented)

Booth #2027

We are excited to introduce the only patented glutathione in the market with over 90% absorption with topical use. Central Drugs is the exclusive distributor; available to all healthcare providers.The patented base has a distinct sulfuric odor and stickiness which dissipates within seconds. Both elements are indications of its potency. Experience the magic of the only patented topical glutathione!

To order call Central Drugs Pharmacy at 877-447-7707

Central Drugs Pharmacy | Ph: (877) 447-7077 | www.centraldrugsrx.com

ResverChron

Booth #1020

Chronobrands is pleased to present ResverChron, the first all-inclusive chronobiology-based regimen for anti-aging. ResverChron is a well-balanced combination of the best-researched vitamins, minerals, nutrients, and plant substances for supporting healthy cellular inflammatory processes, protecting against oxidative stress, maintaining a healthy cardiovascular and nervous system, and promoting healthy cell growth. ResverChron’s carefully-formulated AM/PM doses assure that vital substances are administered in the optimal combination at the right time of day, to ensure optimal anti-aging results.

Chronobrands, Inc. | Ph: (855) 247-6668 | www.chronoceuticals.com

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InnoPen - Microneedling Device Booth #7049

Our InnoPen an MTS Rollers are manufactured in the USA, are FDA-registered, and contain all medical grade materials. The InnoTips (needle cartridges) and MTS Rollers utilize surgical grade stainless steel and GE Lexan Polycarbonate Resin Plastic. The InnoTips have a dual spring, double enclosed tip that is ideal for encouraging needle penetration at a perfect 90 degree angle and has a double enclosed tip to prevent backflow and cross contamination. The tips and rollers are also packaged in a sterile medical hematic pouch as well. Also, all of our clinical solutions, post-procedure, & special care products are made here at our lab in Brea.

Clinical Resolution Lab., Inc. | Ph: (213) 384-0500 | www.skincarecrl.com

Peptide Aqua Gel Mask Booth #7049

MTS Peptide Aqua Gel Mask is highly recommended to be used after in-office treatments such as microneedling, laser, RF, IPL, chemical peels, facial injections, etc. to help calm, soothe, reduce redness, and moisturize the skin. Gel Mask is embedded with Peptide & Collagen solution which gives additional anti-aging effects. To enhance the cooling effect, we recommend it to be refrigerated prior to use.

Clinical Resolution Lab., Inc. | Ph: (213) 384-0500 | www.skincarecrl.com

Phytocann-Omega

Booth #2042

The combination of CO2 extracted perna oil and DMG is a patented combination (US Patent 7229646) geared toward supporting healthy joint and immune function.

DaVinci Laboratories of Vermont | Ph: (800) 325-1776 | www.davincilabs.com

Dna Skin

Booth #9039

Look younger for longer -with a dnalife® test Genetics determines many things about us, including our individual ageing response. dnalife® test results help clinicians develop personalized lifestyle strategies including, nutrition, exercise, nutraceutical and cosmeceutical recommendations. Here are just some of the gene variations dnalife® looks for: Brain function - mood and neurodegeneration. Exercise potential.

Weight management. Inflammation and oxidative stres. Detox and hormonal balance. Firmness and elasticity of the skin. Knowing your dnalife® genes is truly anti-aging.

Dnalife | Ph: (413) 749-5509 | www.dnalife.healthcare

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ANNOUNCEMENTS GI360™ by Doctor’s Data, Inc. Booth #8026

The GI360™ Profile by Doctor’s Data, Inc. is a gut microbiota DNA analysis tool that identifies and characterizes the abundance and diversity of more than 50 targeted analytes that peer-reviewed research has shown to contribute to dysbiosis and other chronic disease states. The GI360™ can identify the presence of 15 pathogenic viruses, bacteria, and parasites using multiplexed, real-time PCR. The identification of pathogenic bacteria, viruses and parasites improves treatment strategies and patient outcomes.

Doctor’s Data, Inc. | Ph: (800) 323-2784 (US & Canada) | +44 08712 180 052 (UK) | +1 630-377-8139 (Elsewhere) | www.doctorsdata.com

C8 Max MCT Powder

Booth #1024

C8 Max MCT Powder from Douglas Laboratories® is a novel medium-chain triglyceride (MCT) that delivers 10 g of concentrated caprylic acid (C8) to support cognitive function and weight management by enhancing endogenous ketone production. This neutral-tasting powder easily mixes into beverages and can be used in cooking for an extra boost of dietary MCT.

Douglas Laboratories | Ph: (800) 245-4440 | www.douglaslabs.com

Flex ES Joint Nutrients Booth #9037

Liquid is key for best cell assimilation with these nutrients and Flex ES has it all-Glucosamine, MSM, Type 2 Collagen, Chondroitin, Hyaluronic acid, Beet root, Pineapple, White Willow (anti-inflammatory). NSF certified. Formulated and manufactured domestically under strictest governmental protocols. No GMO’s, gluten free, no irradiation and no sugar or harmful synthetic sweetners (monk fruit). Flex ES tastes great and works fast. Your patients will be amazed.

Eniva Health | Ph: (260) 615-8057 | www.eniva.com

PEA+

Booth #2061

Enzyme Science now offers (PEA)+, a unique blend of Palmitoylethanolamide from safflower seed, paired with the well-researched, patented, highly-bioavailable curcumin, Meriva® Phytosome. Supplementation of PEA works with the body to calm discomfort and promote levels of wellbeing by enhancing the effects of the (bliss molecule) when it binds to CB receptors*. In combination with Meriva® Curcumin, this formula provides natural support for the whole body with a focus on the nervous, immune, and muscular systems*

Enzyme Science | Ph: (855) 281-7246 | www.enzyscience.com

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GI Motility Complex

Booth #2061

In response to professional demand, Enzyme Science has formulated GI MOTILITY COMPLEX. The unique VEGAN formula features a patented combination of standardized Artichoke Leaf and Ginger Root extract at clinically studied levels shown to support gastro-intestinal motility and transport.

Paired with Apple Cider Vinegar powder, derived from wild picked apples, GI Motility Complex also promotes healthy stomach acidity and delivers beneficial micro-organisms from THE MOTHER.

Enzyme Science | Ph: (855) 281-7246 | www.enzyscience.com

myDNAge® Booth #4091

The myDNAge® Test is the gold standard of the biological age prediction test. The test is able to precisely determine one’s biological age, as opposed to chronological age via a drop of blood or a small urine sample. The test is based on Dr. Steve Horvath’s Epigenetic Aging Clock and utilizes Next Generation Sequencing technology to scan over 2,000 sites in the human genome in order to make the most accurate age prediction.

Epimorphy, LLC | Ph: (833) 693-6243 | www.mydnage.com

Purifying Wash & Purifying Spot Gel

Booth #7032

Introducing the new, powerful ace-fighting duo from Epionce – Purifying Wash and Purifying Spot Gel. Purifying Spot Gel was clinically proven in a head-to-head study to clear acne blemishes faster than the leading prescription clindamycin/benzoyl peroxide product. Designed specifically for adult acne, the unique Epionce approach to clearing blemishes combines new moieties of traditional acne-fighting ingredients with botanicals that provide proven therapeutic benefit without dryness, irritation or redness. Clinical study on file at Episciences, Inc.

Epionce | Ph: (866) 374-6623 | www.epionce.com

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ANNOUNCEMENTS Methylation Panel Booth #5013

The Methylation Panel is an innovative test designed to offer insight into the critical biochemical methylation pathway. Methylation metabolites are measured in plasma, and genetic single nucleotide polymorphisms (SNPs) are analyzed via buccal swab. The results are synthesized on a front-page Interpretation-at-a-Glance (IAAG) graphic for quick methylation status assessment.

Within the report, results are shown in a methylation pathway graphic to provide a clear understanding of the biochemistry involved.

Genova Diagnostics | Ph: (800) 522.4762 | www.gdx.net

Micro Sampling via blood analysis kit

Booth #3103

GX Sciences is proud to announce that we are the 2nd lab in the U.S. to offer micro sampling testing to provide an easy and quick turnaround process to our providers on blood analysis. Benefits of Microsampling: Allows for home or clinic sampling so the patient does not have to visit a draw station to give blood. Does not require refrigeration and special handling during shipment. Is less painful, stressful and the patient can provide the sample in their own home if needed. Can be performed on those for whom maintaining blood volume/measurements is critical. Provider may drop ship a kit to a patient so they have the results prior to the patient consultation.

GX Sciences | Ph: (844) 258.5564 | www.gxsciences.com

Diabetes Predict Genetic Kit Booth #3103

DIABETES PREDICT® IS THE DIABETES PREDICTION GENETIC TEST WHICH ALLOWS YOU TO: 1) Discover your genetic predisposition and that of your family who suffer from type 2 diabetes with a simple cheek swab test. 2) Prevent type 2 diabetes from happening by following our lifestyle recommendations, nutrient suggestions, and recommended diets based on your DNA results. 3) Use tools which help your prevention of type 2 diabetes if you are at medium or high risk.

GX Sciences | Ph: (844) 258.5564 | www.gxsciences.com

MINT PDO Booth #3074

HansBiomed USA Inc’s MINT, Minimally Invasive Nonsurgical Thread, is a safe and effective PDO thread for soft tissue approximation to a desired position. MINT PDO’s molded barbs are bidirectional & helically positioned to provide instant results with minimal pain & scarring and rapid recovery for patients. MINT has superior tensile strength of USP 1-0 to provide an anchorage strength that is four times stronger than the conventional cut threads.

HansBiomed USA Inc. | Ph: (562) 777-7043 | www.mintpdo.com

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Intranasal or Sublingual Oxytocin

Booth #9049

Our uniquely stabilized oxytocin is formulated either in a sublingual or intranasal dosage form.

Research has demonstrated that oxytocin sublingual or intranasal formulations can improve patients’ overall mood and connectedness, enhance sexual arousal, promote sexual intimacy, and generated higher scores in regards to quality of life and happiness.

Harbor Compounding Pharmacy | Ph: (800) 564-1565

www.harborcompounding.com

Dr. Wilson’s Cortisol Stress Reset Booth #8032

Cortisol calming support for stressed-out people* Formulated by Dr. James L. Wilson to moderate cortisol and enhance relaxation, mood, energy and sleep when chronically overstressed* Focused amino acids, minerals, natural bioactive compounds and magnolia bark Synergistic combination enhances efficacy of individual ingredients* Optimum amounts of each ingredient for effective support during chronic stress overdrive* pH-balancing formula* Unique integrated sustained release caplet promotes gradual absorption and optimal utilization* Formulated to help calm stress overdrive, balance cortisol levels, enhance relaxation, and support brain and cardiovascular health during chronic stress* * This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

ICA Health, LLC | Ph: (888) Adrenal | www.icahealth.com www.drwilsons.com

Dr Eriks iBed

Booth #3070

Whole BodyPhotobiomodulation. Red/NIR Light Therapy Bed

iMed LED, LLC | Ph: (267) 205-9172 | www.imedled.com

Red/NIR Light Therapy.

Booth #3070 Dr. Erik’s iBox

iMed LED, LLC | Ph: (267) 205-9172 | www.imedled.com

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ANNOUNCEMENTS Electro-Equiscope Booth #7074

A full medical support suite of neurological, musculoskeletal and metabolic applications easily used daily by professional practitioners in multiple venues and personally right at home. Non-Invasive, Individualized Neural Response Technology, the Electro-Equiscope helps harmonize the autonomic nervous system by opening up cellular communication thus increasing production of the bodyâ&#x20AC;&#x2122;s natural energy, ATP.

Intelligent Bioenergetics, Inc. | Ph: (858) 539-6111 | www.IntellBio.com

The Keto-Mojo GKI Blood Glucose & Ketone Multifunction Monitoring System Booth #9055

Keto-Mojo has launched in Europe! Weâ&#x20AC;&#x2122;ve created the first ketone and glucose meter that measures and displays the GKI glucose â&#x20AC;&#x201C; ketone index. Features include auto-coding technology with strips packaged in individual foil pouch for flexibility of use.There is data communication via integrated Bluetooth 4.2 technology with connectivity to the Keto-mojo app.It conforms to the latest ISO and CE Guidelines and is CE approved for both home and professional use.

Keto-Mojo | Ph: (707) 312-0946 | www.keto-mojo.com

X39

Booth #6091

X39 is here!Non-invasive, safe, inexpensive. Patented, wearable, virtually weightless technology looks just like a patch. Uses light to signal the elevation of a copper peptide proven to activate stem cells. Researchers from around the world have inquired about this breath-taking science that does something big pharma has not been able to do: help people look, feel, perform and heal better. X39 helps reset stem cells to a healthier, more outhful state. Using is believing!

LifeWave | Ph: (623) 748-8946 | www.lifewavex39.com

TM

LightStim ProPanel

Booth #3046

Introducing the LightStim ProPanelâ&#x20AC;&#x201D;Four hands-free models, FDA-cleared to treat full face wrinkles and mild to moderate acne, relieve pain, and promote local blood circulation for recovery and repair. Powered

by LightStim MultiWaveÂŽ Patented Technology, the ProPanel has 1,400 LEDs distributed among four panels for increased contour to the treatment area to help achieve dramatically greater results. US manufactured, the ProPanel is a versatile modality that can boost the results of all of your services.

LightStim | Ph: (949) 502-4088 | www.lightstim.com

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LightStim SheetMasque Booth #3046

The new LightStim SheetMasque combines the latest innovation in bio cellulose technology with wrinkle reducing peptides, antioxidants, and hydrators to form a breathable “second skin” to infuse, hydrate, nourish, and protect. This near-transparent masque may be used in the treatment room with LightStim LED devices or on its own in conjunction with aesthetic services. The LightStim SheetMasque may also be sold as home care to help support a healthy, glowing complexion between professional visits.

LightStim | Ph: (949) 502-4088 | www.lightstim.com

Lypo-Spheric™ Magnesium L-Threonate Booth #6067

Liposomal Magnesium L-Threonate: The Ultimate Brain Supplement. 1000 mg of Magnesium L-Threonate, the only compound scientifically proven to raise brain magnesium levels. Oral administration reversed brain age in older adults with cognitive decline in a recent double-blind, placebo-controlled clinical study. Encapsulated in liposomes for superior absorption, including 500 mg of phosphatidylcholine for neurotransmitter synthesis. Visit LivOn Labs at Booth 6067 for free samples.

LivOn Labs | Ph: (866) 790-2107 | www.livonlabs.com

Complete all-in-one Ready-to-Use E-Beam Terminal Sterilization and Packaging Solution for powder CSP’s Booth #7092

Medizap is proud to disrupt the industry yet again with a ready-to-use all-in-one Terminal Sterilization and Packaging Solution for new powder CSP’s! Medizap has engineered and validated best-in-class components to provide you with a superior primary packaging solution that involves NO CRIMPING! Our new vial & closure system comes sterile in both 6ml & 10ml for use with a variety of drug types.

Medizap | Ph: (415) 572-6984 | www.medizap.co

Kraft Pre-diabetes Profile Booth #8033

The Kraft Pre-diabetes Profile is a new way to evaluate glucose dysregulation, insulin resistance, and pancreatic ß-cell exhaustion earlier and more reliably than fasting glucose, fasting insulin, or hemoglobin A1c testing. The test evaluates glucose and insulin responses, over a four-hour period, after an oral glucose challenge. Serial testing can monitor the effects of diet, lifestyle and nutritional changes. The test may be performed by blood draw or fingerstick methods, for at-home collection convenience!

Meridian Valley Lab | Ph: (855) 405-TEST | www.meridianvalleylab.com

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ANNOUNCEMENTS Hemp Advantage™ Booth #6007

“Hemp Advantage™ features organic, broad-spectrum hemp extract sourced from aerial plant parts (stalk, stems, seeds, and flower). Hemp Advantage upgrades the naturally occurring compounds found in hemp extract with desirable phytocannabinoids and a proprietary blend of terpenes such as β-caryophyllene (BCP) from cloves and pepper. • Precise capsule dosing • European Certified Organic and USDA Organic • Non-GMO, gluten-free, vegetarian • Glyphosate-tested • TruQuality: Transparency you can trust “

Metagenics | Ph: (800) 692-9400 | www.metagenics.com

NEURO FUEL Booth #2036

NEURO FUEL™ --> (previously named CILTEP®) is a patented natural formula that acts as fuel for your neurotransmitters, allowing for fluid thought and efficient mental processing. NEURO FUEL™ is designed to support long-term memory retention and safely enhance the brain’s ability to remain sharply motivated and focused for hours. It works by naturally elevating levels of cAMP, messenger mole. NEURO FUEL™ is a patented natural formula that acts as fuel for your neurotransmitters, allowing for fluid thought and efficient mental processing.

Natural Stacks | Ph: (855) 678-2257 | www.naturalstacks.com

Indigo Greens Booth #4027

Indigo Greens provides beneficial nutrients from berries, fruits, vegetables and greens to support balanced nutrition. The formula combines concentrated, organic fruits and berries with a vegetable antioxidant blend to help build antioxidant reserves and protect the body from free radical damage.

In addition, Indigo Greens provides 16 superfoods to boost energy levels and is FODMAPcompliant. Indigo Greens is available in capsules and powder.

Ortho Molecular Products | Ph: (800) 332-2351 www.orthomolecularproducts.com

Pellecome Fit

Booth #8074

The Revolutionary Advancement in Weight Loss and Bio-identical Hormone Replacement Therapy. Pellecome Fit is a customized medical treatment program based upon an individual’s metabolic and hormonal needs to support optimal health, recovery, and maximize the Power to Perform. The goal is to optimize the health and performance of each individual based upon their specific needs in either recovery or enhancement. The Pellecome Fit program optimizes body composition, building muscle, craving control, metabolic support, and beauty.

Pellecome LLC | Ph: (888) 773-9969 | www.pellecome.com

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Pneuma Nitric Oxide Activating Serum

Booth #3062

Pneuma Nitric Oxide Activating Skin Serum is a patent pending, innovative dual chamber technology that produces nitric oxide gas when the contents of both chambers are mixed together. Loss of nitric oxide with aging leads to poor circulation and blood flow to the small blood vessels of the skin.This results in poor complexion, loss of barrier function and increased inflammation.Therefore in people that have lost the ability to produce nitric oxide by the cells in the skin, nitric oxide has to be produced for them. That is the beauty of the Pneuma Nitric Oxide Skin Serum. If your body cannot produce nitric oxide, we do it for you.

Pneuma Nitric Oxide, LLC | Ph: (877) 476-3862 or (877) 4PNEUMA

www.pneumanitricoxide.com

Podcasting and Videos Made Easy - LIVE! - Workshop Booth #2088

Quickly and easily create a pro-quality podcast and YouTube channel designed to multiply the sales of your services by ten times, in just one weekend - even if you’re a non-techie. This workshop includes world-class, step-by-step, in-person training by podcast and video experts, effective fill-inthe-blank scripts and templates, hands-on exercises with expert coaching, a custom podcast intro recorded by a professional voiceover artist, PLUS all the pro gear you need INCLUDED to reproduce the same results at home.

Podcasting and Videos Made Easy | Ph: (248) 705-7893 www.podcastingandvideosmadeeasy.com

Premier Fermented Greens Capsules Booth #2060

Premier Fermented Greens provides a highly bioavailable, fermented vegetarian prebiotic blend of the most exquisite greens that also includes LIVE PROBIOTICS! This extraordinary, gluten free, fermented plant blend features a prebiotic greens blend of: Fermented Organic Barley Grass, Fermented Organic Oat Grass, Fermented Organic Kale, Fermented Organic Chlorella plus a garden blend of 100% fermented vegetarian greens air-dried at a low temperature to deliver naturally occurring vitamins and minerals to promote the body’s natural alkalinity.

Premier Research Labs | Ph: (800) 325-7734 | www.prlabs.com

SunButyrate™-TG liquid Booth #1026

Available only through Pure Encapsulations®, SunButyrate™-TG liquid is a great-tasting, proprietary, butyrate-rich triglyceride oil to promote gut barrier integrity. It delivers butyrate, which is the main energy source for the cells lining the GI tract, directly to the intestine for improved bioavailability.

Pure Encapsulations | Ph: (800) 753-2277 | www.pureencapsulations.com

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ANNOUNCEMENTS NAD+ Elixir™ Booth #5021

Introducing NAD+ Elixir™: A Stable NAD+ Activator and Powerful Age Management Molecule.

NAD+ is a powerful cofactor in energy production that diminishes with age. The most effective way to replenish NAD+ is with Nicotinamide mononucleotide (NMN), a direct precursor of NAD+ and the centerpiece of the ultimate age management supplement, NAD+ Elixir. NMN has been found to support mitochondrial function, cellular repair, normal insulin levels, weight management, and neuronal function. Quicksilver Scientific® delivers this powerful anti-aging compound as a liposomal nanoparticle for quick cellular uptake and optimal efficacy.

Quicksilver Scientific | Ph: (303) 531-0861 www.quicksilverscientific.com

ReeCure Anti Ageing Face Cream and Hair Loss Serum

Booth #7104

Whether you’re ready or not, ageing happens! Wrinkles and age spots appear and hair starts to fall.

After a decade of research we finally have a solution - the ReeCure Anti Ageing Face Cream and Hair Loss Serum. Carefully curated separately for men and women, the advanced propriety cream and serum contain Bio Active Protein along with other clinically tested ingredients that have proven to reduce wrinkles and age spots (cream) and stop hair fall (serum).

ReeLabs Private Limited | Ph: +919 820 180076 | www.reecure.com

Cellular Optimizer Booth #4039

Promote tissue vascularization, mitochondrial biogenesis and oxidative metabolism. Increase overall energy production, maximize endurance capacity, enhance cognitive function and promote reduction of oxidative stress and the effects of aging. Targeted for cardiovascular health, sexual health, cognitive health. Support healthy mitochondria and endothelial function Formula exclusive to practitioner channel. Current clinical trial for endothelial function. Unique formulation of standardized, branded PQQ, H2Q® CoQ10, Oxystorm®, L-Arginine, and Epicatechin as PhytoSure™, each demonstrating their effectiveness in published studies.

Rejuvenation Science | Ph: (310) 798-2830 www.rejuvenation-science.com

Resync Recovery Blend

Booth #8046

Resync Recovery is a science-based natural nitric oxide superfood blend of red spinach, red beets, and aronia berries to boost energy and promote faster recovery from physical activity. When you drink Resync Recovery blend, you know you are getting the functional benefits of all of the standardized natural nitric oxide superfoods not just red beets! Our powerful blend is also supported with mango extract, ginger, a new twist of turmeric extract, hyaluronic acid, & inulin.

Resync LLC | Ph: (561) 469-7655 | www.resyncproducts.com

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Resync Collagen Blend

Booth #8046

Resync Collagen is a combined super blend of natural nitric oxide precursors and hydrolyzed collagen peptides mixed with a daily value of vitamin C to maximize the synthesis of collagen production. In one scoop of 20.9g, you receive 15g of collagen protein, and other superfoods like red spinach, red beets, and aronia berry combined with calcium fructoborate, hyaluronic acid, and antioxidant vitamin C. Resync collagen is tested by the gold standard in dietary supplement certification BSCG certified drug free.

Resync LLC | Ph: (561) 469-7655 | www.resyncproducts.com

P2 Hair Science Cellular Hair Regrowth System Booth #2033

This innovative hair regrowth system includes a 90-day protocol of regenerative biologics and pharmaceutical peptides combined with specific injection techniques; each supported by clinical studies proving cellular hair regeneration. The home care treatment includes professional cosmeceutical hair care products from the Amazon region in Brazil. The 100% vegan, proprietary formulation in each product is backed by clinical studies and a portion of each product sale is donated to a charity organization supporting orphans and widows.

Specialty MED Training | Ph: (561) 408-7248

www.specialtymedtraining.com/hair-regrowth-training

Olprima™ EPA

Booth #6079

Olprima EPA provides condition-specific support through a high concentration of the omega-3, EPA. Olprima EPA provides general mood support while promoting a healthy inflammatory response.* *These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure, or prevent any disease.

Standard Process | Ph: (800) 558-8740 | www.standardprocess.com

Olprima™ DHA Booth #6079

Olprima DHA provides condition-specific support through a high concentration of the omega-3, DHA. Olprima DHA supports cardiovascular and brain health while supporting the body’s healthy inflammatory response.* *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Standard Process | Ph: (800) 558-8740 | www.standardprocess.com

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ANNOUNCEMENTS

TA-65

Booth #5007

T.A. Sciences, the creators of TA-65, is launching the newest addition to their telomere lengthening supplement lineup with NEW TA-65 250 Unit scored tablet. This new size is easy to use, and provides flexibility in your daily dosing regimen.

T.A. Sciences | Ph: (888) 360-8886 | www.tasciences.com

DHH-B

Booth #7011

DHH-B, dihydrohonokiol-B, is a natural supplement which has anxiolytic-effects. Treatment with DHH-B does not cause any significant changes in motor activity or muscle relaxation. Benzodiazepines are some of the most commonly prescribed medications in the United States. These anxiolytics have many well-known side effects including motor function and more. That being said, this product has the potential to help people transition from benzodiazepines to DHH-B or act as an alternative to benzodiazepines.

Tailor Made Compounding | Ph: (859) 887-0013

www.tailormadecompounding.com

Jubilance Booth #4070

Jubilance (oxaloacetate) is a nutritional supplement for relief of Emotional Premenstrual Syndrome (PMS). In randomized, blinded, placebo-controlled trials, Jubilance significantly reduced Anxiety and Gloomy Mood by over 50%. Perceived Stress and Irritability were also significantly reduced. Each bottle of Jubilance states the USFDA submitted Structure/Function Claim: “Oxaloacetate may help alleviate the mild to moderate psychological and/or behavioral symptoms associated with Premenstrual Syndrome (PMS).” Recommended by doctors, Jubilance is a ground breaking supplement for women

Terra Biological LLC | Ph: (858) 947-5722 | www.Jubilance.com

Tigosol

Booth #7062

Tigosol, “just released”, is a unique triple ingredient formula combining vitamin D3, green tea extracts and Bacillus subtilis cultures. The “Sun Vitamin” D3 is known for aiding the immune system, promoting bone, teeth and muscle health. The green tea extracts provide beneficial EGCG. The Bacillus subtilis cultures can be beneficial in numerous ways including anti-aging. Tigosol Vitamin D Complex and Tigovit Green Tea Complex may be taken together as an optimal supplement combination.

Tigovit | Ph: (941) 313-0358 | www.tigovitus.com

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Tigovit green complex

Booth #7062

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ANTI - AGING MEDICAL NEWS • WINTER 2019

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The Science Behind NMN

A Stable, Reliable NAD+ Activator and Anti-Aging Molecule By: Christopher Shade, PhD The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging. The classification of aging as a disease paves the way for new research into novel therapeutics to delay or reverse age-related illnesses such as cancer, cardiovascular and metabolic disease, and neurodegeneration., Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.

Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair. In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects

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in susceptible organs and tissues.”

Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication., By middle age, our NAD+ levels have plummeted to half that of our youth. Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan., NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside( NR) and nicotinamide mononucleotide (NMN)., A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6 Taken orally, NMN is rapidly absorbed and converted to NAD+.

ANTI - AGING MEDICAL NEWS • WINTER 2019

The Science Behind NMN - A Stable, Reliable NAD+ Activator and Anti-Aging Molecule

In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed agerelated adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+. Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.

PATHWAYS TO NMN IN THE HUMAN BODY A veritable symphony of interlocking transformations allows NAD+ to be both synthesized and regulated in the body. It is well known that vitamin B3 is a building block for Nicotinamide adenine dinucleotide (NAD+). It is also widely recognized that NMN is a potent precursor for NAD+. Though NMN is naturally found in small amounts in fruits and vegetables such as avocados, broccoli, cabbage, edamame, and cucumbers, in mammals most NMN is synthesized from vitamin B3 in the form of nicotinamide. At the center is nicotinamide phosphoribosyltransferase (NAMPT), an essential rate-limiting enzyme that catalyzes the conversion from nicotinamide to NMN, which exists in both an intracellular (iNAMPT) and extracellular form (eNAMPT). The extracellular form has higher enzymatic activity than the intracellular form and has been found in blood plasma, seminal plasma and cerebrospinal fluid in humans., In addition, eNAMPT appears to be produced by a wide array of cell types— including fat (adipocytes), liver (hepatocytes), white blood cells (leukocytes and monocytes), and heart and brain cells (cardiomyocytes and glia cells). Like NAD+ and NMN, eNAMPT declines with age. Both white and brown adipocytes actively secrete eNAMPT, suggesting that fatty tissue may be a modulator of NAD+ biosynthesis.6 Adipose tissue actively secretes extracellular vesicles (EVs) that are enriched with NMN, and can circulate through the plasma. EVs are membrane-derived particles surrounded by a phospholipid bilayer that are released by cells in the human body. These EVs not only protect their cargo, they can deposit their payload where needed.

NMN and NR dance together. NMN can be converted by the body to NR, which then enters cells, and is converted back to NMN by an enzyme called nicotinamide riboside kinase (NRK). More recently, an “elusive’ transporter was discovered, which can transport NMN directly into cells. NMN is transported across cell membranes directly into the cytoplasm of the cell, by an enzyme called Slc12a8. Uptake pathways of NMN vary with tissue types, and interestingly, Slc12a8 expression is about 100-fold times higher in the small intestine of mice than the brain or adipose tissue.

Researchers speculate that the gut microbiome, and certain resident bacteria within it, may produce NMN. NMN levels fall with age, and aging itself has also been shown to significantly compromise the body’s conversion of NMN to NAD+.

ABUNDANT EVIDENCE FOR ANTI - AGING AND HEALTH ENHANCING EFFECTS OF NMN In numerous mouse models of disease and aging, NMN has demonstrated a wide array of remarkable effects, benefitting conditions ranging from diabetes to Alzheimer’s disease to ischemia. Orally administered NMN is quickly synthesized into NAD+ in tissues in mice. NMN has been able to suppress ageassociated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression. In mice bred to be diabetic or obese, NMN improved both the action and secretion of insulin. NMN also protected the mouse heart from ischemia and/or reperfusion injury. It has restored skeletal muscle in aged mice, and slowed cognitive decline in a mouse model of Alzheimer’s disease, by improving the survival of neurons, improving energy metabolism, and reducing reactive oxygen species. It may help maintain the integrity of the blood brain barrier. NMN is likely a good candidate to suppress inflammaging—the increase in inflammation associated with aging—since studies show it lowers adipose tissue inflammation associated with age. In fact, older mice appear to be more responsive to NMN, in comparison with young mice.

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The Science Behind NMN - A Stable, Reliable NAD+ Activator and Anti-Aging Molecule

NMN appears to be stable in water; in one study 93%–99% of NMN was maintained intact in drinking water at room temperature for 7–10 days.

NMN also appears to be rapidly absorbed. When given to mice by oral gavage, there was a steep increase of plasma NMN in a mere two and a half minutes, with further increases at 5-10 minutes. Plasma levels then declined to baseline, suggesting rapid absorption in the gut.29 Long-term (1-year) NMN given orally, in doses of up to 300 mg/kg, was found to be safe and well tolerated in normal mice.29

LOOKING FORWARD: NMN AND HUMAN HEALTH NMN is clearly a murine fountain of youth. But what about humans? Shin-ichiro Imai has said that NMN

may improve adult human metabolism, rendering it more like that of someone ten or twenty years younger. His team is now studying NMN in humans.

David Sinclair, Harvard University’s noted anti-aging researcher, whose research on resveratrol, NAD+ and sirtuins is world renowned, is also conducting human trials. He is taking NMN himself; he has said his lipid profile has improved dramatically and he feels more energetic and that his blood markers, at nearly 60 years old, are closer to those of a 31-year-old., An interesting question is the delivery system for oral NMN: the EVs that transport the molecule through plasma in the body are liposomes. A liposomal version of NMN may well mimic the body’s own transport system, enhancing uptake and delivery, as science advances its understanding of the holy grail of reversing aging.

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Zhavoronkov A et al. Classifying aging as a disease in the context of ICD-11.

Front Genet. 2015 Nov 4;6:326

Blagosklonny MV. Disease or not, aging is easily treatable. Aging (Albany NY).

2018 Nov 17;10(11):3067-3078

22. Yoshino J et al. NAD+ Intermediates: The biology and therapeutic potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528

López-Otín C et al. The hallmarks of aging. Cell 2013;153(6):1194-1217

24. Yoshida M. Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice. Cell Metab. 2019 Aug 6;30(2):329-342.e5

Editorial. Opening the door to treating ageing as a disease. Lancet Diabetes Endocrinol. 2018 Aug;6(8):587

Schultz MB et al. Why NAD+ Declines during Aging: It’s Destroyed. Cell Metab.

2016 June 14; 23(6): 965–966 Imai S. The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control.

NPJ Syst Biol Appl. 2016 Aug 18;2:16018 Conboy IM et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433: 760–764.

de Magalha˜ es JP et al. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 2009: 25: 875–881.

10. Zhu XH et al. In vivo NAD assay revels the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl. Acad. Sci. 2015; 112:2876–2881

11. Suave AA. NAD+ and vitamin B3: from metabolism to therapies J Pharmacol Exp Ther. 2008 Mar;324(3):883-93 12. Lee CF et al. Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease. Sci Rep. 2019 Feb 28;9(1):3073 13. Camacho-Pereira J et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 Jun 14;23(6):1127-1139

14. Longo VD et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14 (4): 497-510.

15. Poljsak B. NAMPT-Mediated NAD biosynthesis as the internal timing mechanism: in NAD+ World, time Is running in its own way. Rejuvenation Res. 2018 Jun;21(3):210-224 16. Johnson S et al. NAD + biosynthesis, aging, and disease. F1000Res. 2018 Feb 1;7:132

17. Yoshino J et al. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513-528

18. Revollo JR et al. The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem.

2004; 279:50754–50763 19. Mills KF et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016; 24:795–806

20. Hallschmid M et al. Relationship between cerebrospinal fluid visfatin (PBEF/ Nampt) levels and adiposity in humans. Diabetes. 2009; 58:637–640 21. Friebe D et al. Leucocytes are a major source of circulating nicotinamide

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phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans. Diabetologia. 2011; 54:1200–1211

23. Van der Meel R et al. Extracellular vesicles as drug delivery systems: lessons from the liposome field. J Control Release. 2014 Dec 10;195:72-85

25. Wu LE et al. The elusive NMN transporter is found. Nat Metabo 2019;1(1):8-9

26. Grozio A et al. Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab.

2019;1(1):47–57.

27. Imai, S. Diagnostic and therapeutic applications of a novel plasma metabolite, Nicotinamide Mononucleotide (NMN), for age-associated metabolic complications in humans. Longer Life Foundation 2011. Available at: http://www. longerlife.org/mm/files/LLF%20Final%20Report_IMAI.pdf Accessed 9-1-2019 28. Keisuke Okabe et al. Implications of altered NAD metabolism in metabolic disorders. Journal of Biomedical Science 2019;26:34

29. Mills KF et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016 Dec 13;24(6):795-806

30. Caton PW et al. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function. Diabetologia. 2011 Dec;54(12):3083-92 31. Yamamoto T. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014 Jun 6;9(6):e98972.

32. Mendelsohn AR et al. Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels.

33. Rejuvenation Res. 2014 Feb;17(1):62-9.

34. Wang X et al. Nicotinamide mononucleotide protects against β-amyloid oligomerinduced cognitive impairment and neuronal death Brain Res. 2016 Jul 15;1643:1-9 35. Wei CC et al. NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activatorinduced haemorrhagic transformation after cerebral ischaemia. Br J Pharmacol.

2017 Nov;174(21):3823-3836 36. Anti-Aging compound in human clinical trial: will boosting NMN slow aging?

Available at: https://hecmedia.org/posts/anti-aging-compound-in-humanclinical-trial-will-boosting-nmn-slow-aging-6/ Accessed 9-1-2019 37. Bolotnikova MN. Anti-aging approaches. Harvard Magazine. Sept-Oct 2017.

Available at: https://harvardmagazine.com/2017/09/anti-aging-breakthrough Accessed 9-1-2019

38. Taylor M. Scientists may be closer than you think to an anti-aging pill. But beware of the hype. Kaiser Health News. Available at: https://www.tampabay.com/health/ medical-news/scientists-may-be-closer-than-you-think-to-an-anti-aging-pill-butbeware-of-the-hype-20190212/ Accessed 9-1-2019

ANTI - AGING MEDICAL NEWS • WINTER 2019

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Nitric Oxide:

Past, Present and Future By: Nathan S. Bryan, PhD Baylor College of Medicine, Houston, TX USA The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine.

The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

INTRODUCTION The discovery of the human production of nitric oxide (NO) over 30 years ago transformed the way we think about treating and preventing cardiovascular related diseases. NO is a transient and gaseous signaling molecule that communicates specific and deliberate signals throughout the body in every organ system.

The human body has two primary pathways to produce nitric oxide.

One can compensate for the other but when production is shut down from both pathways, cells and tissues become dysfunctional followed by symptoms and disease. Loss of nitric oxide production is associated and even causal for most if not all chronic human disease. Therefore, restoring nitric oxide production may be one of the single most important therapeutic strategies for any health care practitioner.

However, finding product technology, either drug therapy or nutritional and supplementation, is confusing and often fraught with products that do not work. The purpose of this article is provide a brief history on nitric oxide, its relevance for human health and where I see the future of NO based technologies.

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HISTORY OF NITRIC OXIDE The chemical properties of NO gas were first characterized in 1772. With the recognition of its importance in industrial use in the preparation of nitric acid as well as its pollutant effects in the atmosphere in the 20th century, considerable literature on its fundamental chemistry emerged.

NO is biologically active in the concentration range from 1-100nM [1] and is lipophilic so that it can readily permeate biological membranes. Due to its very short half-life in vivo, it is important to consider the spatial and temporal aspects of NO production, as well as the complex chemistry in which this seemingly simple molecule can participate. Ferid Murad first described nitric oxide as a vasodilator and elucidated the mechanism of action of organic nitrates such as nitroglycerin in 1977 [2]. Three years later, in 1980 Robert Furchgott discovered that our endothelial cells make a vasodilator substance.

He termed his new discovery endothelium derived relaxing factor (EDRF) [3]. Then in 1987 both

ANTI - AGING MEDICAL NEWS â&#x20AC;˘ WINTER 2019

Nitric Oxide: Past, Present and Future

Salvador Moncada and Louis Ignarro discovered that EDRF described by Furchgott is actually nitric oxide gas [4 5]. These series of discoveries identifying a new paradigm for cell signaling by a gas, nitric oxide, led to a Nobel Prize in Physiology or Medicine in 1998 to Ferid Murad, Robert Furchgott and Louis Ignarro.

This fundamental discovery allowed scientists to understand the regulation of blood flow throughout the body and created new targets for drug discovery.

Historically, nitric oxide was considered a vasodilator.

NITRIC OXIDE TODAY Today with more than 165,000 published scientific papers on nitric oxide, we know it is much more than a vasodilator. Many of the known physiological effects of nitric oxide are known to be independent of the activation of soluble guanylyl cyclase that leads to vasodilation. At its core, it is a signaling molecule that affect protein structure and function [6]. One of its critical functions is the delivery of oxygen off of hemoglobin in the microcirculation. When oxygen rich blood is circulated from the lungs to the periphery, the oxygen is bound to the iron center of hemoglobin. It is nitric oxide that tells the hemoglobin to release oxygen during the arterial/venous transit [7]. Without NO, hemoglobin cannot release oxygen.

So in order for efficient oxygen delivery, you must first have NO produced to dilate the blood vessels to get oxygen to individual cells but also have NO to signal hemoglobin to release the oxygen. Without nitric oxide, there is no oxygen delivery and without oxygen cells becomes dysfunctional and eventually die. NO is also a neurotransmitter in the central and peripheral nervous system [8]. We also know that as people age, they make less nitric oxide [9 10] and this is the primary reason for age related disease [11].

our aging population. Health care practitioners can no longer ignore nitric oxide in their patients. Patients cannot and will not heal without first restoring the production of nitric oxide. Development of NO based therapeutics is and will continue to be a major focus of biotech, pharmaceutical and nutritional companies.

Education of the public and health care practitioners is essential since NO is absolutely necessary for patient health and for healing the human body.

HOW DO YOU KNOW A NITRIC OXIDE PRODUCT WORKS? The challenge is for physicians, healthcare practitioners and patients to understand what is the safest and most efficacious nitric oxide products available to them.

The first thing you must understand is how the body normally makes nitric oxide and then you must recognize what goes wrong in people that cannot make it. If you don’t understand these two fundamental principles, then you can never effectively and efficiently restore your body’s nitric oxide production and as a result, you cannot optimize your body’s performance and health.

There are two ways the body makes nitric oxide 1.

Through an enzymatic reaction using L-arginine and the enzyme nitric oxide synthase (NOS) [12]. This enzyme is found throughout the body, but primarily in the cells that line all blood vessels. L-arginine is a semi-essential amino acid, meaning that your body makes it through normal metabolism in the urea cycle and it is also found in many proteins we eat. When we eat protein and the protein is broken down into amino acids, L-arginine is provided to the body. Unless you have an inborn error in metabolism [13] (which is extremely rare), then your body will always make enough L-arginine to produce NO. The reaction to convert L-arginine to nitric oxide is complex and complicated and requires many different cofactors and substrates. For this pathway to work, the NOS enzyme must be active and functional.

2.

Through the metabolism of inorganic nitrate found in green leafy vegetables and some root vegetables.

Nitrate is absorbed in the gut and concentrated in our salivary glands. There are nitrate reducing

FUTURE OF NITRIC OXIDE It is becoming increasingly clear that most if not all diseases are characterized or associated with perturbations in nitric oxide production/signaling.

Therapeutics or strategies designed to restore normal NO homeostasis will have broad application and utility in human health and profoundly affect the health of

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Nitric Oxide: Past, Present and Future

bacteria that live in the crypts of our tongue that convert nitrate to nitrite and nitric oxide [14].

Our saliva then becomes high in nitrite and when we swallow our own saliva, we get nitric oxide produced in the lumen of the stomach provided there is stomach acid. For this pathway to work, people must consume sufficient nitrate from their diet (300-400mg), must have the right oral bacteria and must have sufficient stomach acid production.

WHAT GOES WRONG IN PEOPLE THAT CAN’T MAKE NITRIC OXIDE? The older we get, the less nitric oxide we make through L-arginine. This is because the enzyme NOS becomes dysfunctional and no longer converts L-arginine to nitric oxide [9]. This is termed endothelial dysfunction.

The other problem is that most Americans do not consume sufficient vegetables to get enough nitrate.

The typical American diet only contains 150mg per nitrate per day. We know we need at least 300 mg of nitrate per serving to lead to any appreciable production of nitric oxide, provided the person has the right oral bacteria and stomach acid production. Statistically, over 200 million Americans wake up everyday and use an antiseptic mouthwash. This represents over half of the US population. Therefore these folks get no nitric oxide benefit from nitrate in their diet or if they are taking a nitrate capsule. To make things even worse, there are over 100 million prescription written every year for proton pump inhibitors and even more for other antacid drugs. Now these drugs can be purchased over the counter. Therefore there may be another 100 million Americans that take antacids that are not reported by the prescription data.

Collectively the majority of Americans become nitric oxide deficient based on their daily diet and hygienic practices along with certain prescription drug use.

HOW DO I FIND A PRODUCT THAT WORKS FOR ME? There are literally hundreds of nitric oxide products on the market. Most of these date back to 1998 after the Nobel Prize was awarded. These initial products contained L-arginine and/or L-citrulline. As described

110

above, there is really never a condition where people are deficient in L-arginine. Therefore taking a L-arginine product will not lead to any improvement in NO production, especially in patients that have endothelial dysfunction. In people that are nitric oxide deficient, the NOS enzyme doesn’t work. Furthermore, at least two clinical trials have demonstrated that giving L-arginine can make things worse [15 16]. Beet products have been popularized most recently. However, most of the beet products on the market do not contain any detectable nitrate so they offer no benefit with regards to nitric oxide production. There are however a few beet root products that have known amounts of nitrate. There is also a product that contains potassium nitrate in a capsule that is sold as a nitric oxide product. These are not nitric oxide products, these are nitrate products that in most cases do not lead to any NO formation or restoration. As described above, if people are using mouthwash, antibiotics, antacids and have poor oral hygiene, these products cannot and will not work [1720]. Statistically this is most of America. The take home message is that beet root does not equal nitrate does not equal nitric oxide. If your body can’t make NO then it makes no sense to give it precursors that it cannot convert. Look for a product that creates nitric oxide gas and actually improves the body’s own ability to produce nitric oxide on its own. This can only be demonstrated through scientific research and clinical trials.

There are 3 questions you must ask yourself when considering a nitric oxide product for your health and wellness.

1.

2.

3.

Does the actual product have any published clinical trials in humans? Clinical trials are expensive and risky so you must have confidence that your product works. Very few companies actually put their product to the ultimate test in clinical trials.

Does the product have any issued patents?

Innovation and product superiority can be distinguished by issued patents.

Is the technology licensed from a reputable University or Medical School? This will ensure there was actually research and some intellectual property on the product or product technology. Any company can put ingredients together but it does not mean there

ANTI - AGING MEDICAL NEWS • WINTER 2019

Nitric Oxide: Past, Present and Future

is science or any valid research to back it. Has the formulator published in the NO field?

If the product passes these three fundamental questions, then you can feel confident that the product may work for you and your patients. There are only a hand full of products on the market that fulfill these requirements.

Unfortunately there are many companies out there that are good at marketing but poor at science. There are clear

deceptive trade practices and outright fraud by many of these companies. Finding an effective nitric oxide product for your patients will be the single most effective thing you can do for your patient. When you restore blood flow and signaling throughout the body, everything gets better. To the contrary, if you fail to address nitric oxide production in your patients, all other therapies will have limited effects. The future of health care and the care of Americans is dependent upon nitric oxide.

BIOGRAPHY: Dr. Bryan has spent the past 20 years researching nitric oxide. His many seminal discoveries in the field of nitric oxide has led to dozens of issued U.S. and International Patents. He has published hundreds of peer-reviewed studies on nitric oxide and is considered an international expert on nitric oxide biochemistry and physiology.

REFERENCES 1. Ignarro LJ. Physiology and pathophysiology of nitric oxide. Kidney Int Suppl 1996;49(55):S2-S5 2. Arnold WP, Mittal CK, Katsuki S, Murad F. Nitric oxide activates guanylate cyclase and increases guanosine 3’:5’-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A 1977;74(8):3203-7 3. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine. Nature 1980;288(5789):373-76 4. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endotheliumderived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad Sci. USA 1987;84:9265-69 5. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327(6122):524-26 6. Stamler JS, Lamas S, Fang FC. Nitrosylation. the prototypic redox-based signaling mechanism. Cell 2001;106(6):675-83 7. Zhang R, Hess DT, Qian Z, et al. Hemoglobin betaCys93 is essential for cardiovascular function and integrated response to hypoxia. Proc Natl Acad Sci U S A 2015;112(20):6425-30 doi: 10.1073/pnas.1502285112 1502285112 [pii][published Online First: Epub Date]|.

8. Garthwaite J, Charles SL, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 1988;336(6197):385-8 doi: 10.1038/336385a0[published Online First: Epub Date]|.

9. Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.

Circulation 1993;88(1):77-81 10. Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension 2001;38(2):274-9 11. Torregrossa AC, Aranke M, Bryan NS. Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly. Journal of Geriatric Cardiology 2011;8:230-42 12. Stuehr DJ, Marletta MA. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc Natl Acad Sci U S A 1985;82(22):7738-42

13. Erez A, Nagamani SC, Shchelochkov OA, et al. Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med 2011;17(12):1619-26 doi: 10.1038/nm.2544 nm.2544 [pii][published Online First: Epub Date]|.

14. Bryan NS, Tribble G, Angelov N. Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure. Curr Hypertens Rep 2017;19(4):33 doi: 10.1007/s11906-017-0725-2 10.1007/s11906-017-0725-2 [pii][published Online First: Epub Date]|.

15. Wilson AM, Harada R, Nair N, Balasubramanian N, Cooke JP. L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.

Circulation 2007;116(2):188-95 doi: CIRCULATIONAHA.106.683656 [pii] 10.1161/CIRCULATIONAHA.106.683656[published Online First: Epub Date]|.

16. Schulman SP, Becker LC, Kass DA, et al. L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. Jama 2006;295(1):5864 17. Kapil V, Haydar SM, Pearl V, Lundberg JO, Weitzberg E, Ahluwalia A. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med 2013;55:93-100 doi: 10.1016/j. freeradbiomed.2012.11.013 S0891-5849(12)01822-9 [pii][published Online First: Epub Date]|.

18. Montenegro MF, Sundqvist ML, Larsen FJ, et al. Blood PressureLowering Effect of Orally Ingested Nitrite Is Abolished by a Proton Pump Inhibitor. Hypertension 2017;69(1):23-31 doi: 10.1161/ HYPERTENSIONAHA.116.08081[published Online First: Epub Date]|.

19. Govoni M, Jansson EA, Weitzberg E, Lundberg JO. The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide 2008;19(4):333-7 20. Petersson J, Carlstrom M, Schreiber O, et al. Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash. Free Radic Biol Med 2009;46(8):1068-75

ANTI - AGING MEDICAL NEWS • WINTER 2019

111

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Our mission at Alletess Medical Laboratory is to provide the best test performance and unsurpassed laboratory testing services to our clients.

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Allergy: Over 200 foods available, pre-established panels with the most common allergenic foods À-la-carte ordering from over 650 allergens: IgE, IgG, specific IgG4 or IgA Regional inhalant allergy panels Multiple mold panels available to assess allergic response and recent exposure Environmental allergen panels Molecular Allergology tests the multiple components of an allergen to better manage your allergies

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Connective Tissue Disease, Rheumatoid Arthritis and Thyroid Disorders Celiac Disease Profile • Candida albicans • H. Pylori Food Sensitivity Panels: Your choice of a 96 or 184 food panel Available as IgG or IgA IgG available as serum or finger stick (dried blood spot)

Why Test for Food Sensitivities?

Days may pass before symptoms appear, testing is often the only way to determine which foods are responsible.

A food sensitivity test can quickly determine reactive foods.

IgG reactions frequently occur to commonly consumed foods such as dairy, wheat, eggs, yeast, pork and soy.

Elimination diets are difficult to follow and can take months to complete.

Studies prove that most patient's symptoms improved when positive foods were removed.

Food Sensitivity Symptoms Impact all Parts of the Body Fatigue, difficulty concentrating, joint pain, inflammation, headaches, migraines, eczema, rashes, skin irritations, stomach aches, acid reflux, bloating, constipation or diarrhea, unexplained weight gain or loss, behavioral issues

96 or 184 IgG and/or IgA Food Sensitivity Panel Finger stick (IgG only) or serum • Easy transport - stable at room temperature No fasting or need to come off most medications or supplements Customized Wellness Plan • On site dietitians

Fast turnaround time - 5 to 7 business days • 40 years of proven results!

Wellness Plan: Available with any Food Sensitivity Test • 15+ page booklet customized for the patient based on their results.

• Custom diets available e.g. vegetarian, vegan, paleo etc.

• Foods to eliminate are clearly identified.

• Resources, such as a shopping list and • A wallet size card that lists the foods the 4-day rotation diet are included to aid the patient needs to avoid is provided making patient in purchasing or preparing food it easy to food shop or eat out selections.

• Available as hard-copy or PDF • Instructions on how to reintroduce foods are included.

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Disclaimer: the headings and descriptions contained within this document are general headings describing formulas, products and services offered by AnazaoHealth Corporation. These general headings are not intended and should not be interpreted to make recommendations or claims regarding the use, efficacy or safety of products, formulas and/or services listed herein. Only a doctor or other appropriately licensed health care professional, as a learned intermediary, can a determine if a formula, product or service described herein is appropriate for a patient.

The trademarks listed herein are the property of their respective owners.

AnazaoHealth®, Anazao®, Create, Heal, Live.®, and the Compass are registered trademarks of AnazaoHealth Corporation, © 2019. All Rights Reserved. C9-091219

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DO YOU HAVE FULL CONFIDENCE YOUR SUPPLEMENT COMPANY IS TAKING EVERY MEASURE TO ENSURE THE QUALITY OF SUPPLEMENTS YOUR PATIENTS CONSUME

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questionable excipients. Although excipients and lubricants are often used in products to assist machinery to run faster and cheaper, these undesirable agents end up in your product. PRL does NOT believe in compromising the quality of our products with the use of these agents.

eted USP certification. This stringent manufacturing certification has only been achieved by a handful of companies in the U.S. This most prestigious stamp of excellence certifies your patient that PRL’s quality systems result in the creation of products that are safe and trustworthy.

lab along with third party testing dedicated to the use of advanced analytical methods for ingredient testing including: ● HPLC ● gas chromatography ● mass spectrometry ● high performance crystal spectroscopy ● DNA Testing ● TLC ● Microscopy

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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27TH

FOOD SERVICE AREA

ANNUAL WORLD CONGRESS

CONCESSION STAND

CONCESSION STAND

3105 4104

6105

7104

3103 4102

6103

7102

4100

7100

6097

7096

6095

7094

3092

7093 7090

2081

3072

5074

5075

6074

6070

3070

3063 9061

A4M

1057

4055

9056

9054

5055

2048 8047

9046 9044 9042

1039

9034

9023

40’

45’

7011 3009

7005

ANTI - AGING MEDICAL NEWS • WINTER 2019

FLOOR PLAN

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2073

EXHIBIT

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127

EXHIBITOR

INDEX 4 life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8103 A Digital Health Guide . . . . . . . . . . . . . . . . . . . . . . 6027 A Hemp World . . . . . . . . . . . . . . . . . . . . . . . . . . . 3042 Absolute Pharmacy . . . . . . . . . . . . . . . . . . . . . . . . 2048 AC Grace Company . . . . . . . . . . . . . . . . . . . . . . . . 3038 Access Medical Labs . . . . . . . . . . . . . . . . . . . . . . . . 4042 AccuVein, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . 4090 Accuview Imaging . . . . . . . . . . . . . . . . . . . . . . . . . 4045 Acella Pharmaceuticals . . . . . . . . . . . . . . . . . . . . . . 3100 Adit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6096 Advice Media . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8044 Aerodiagnostics . . . . . . . . . . . . . . . . . . . . . . . . . . 1052 Aesthetic Management Partners . . . . . . . . . . . . . . . . . 2054 Aesthetics Biomedical . . . . . . . . . . . . . . . . . . . . . . . 5094 AgelessLX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8036 Agnes Medical . . . . . . . . . . . . . . . . . . . . . . . . . . . 3072 Allergy Research Group . . . . . . . . . . . . . . . . . . . . . . 8027 Alletess Medical Laboratory . . . . . . . . . . . . . . . . . . . 2032 American Biotech Labs . . . . . . . . . . . . . . . . . . . . . . 5043 American Herbal Labs & Nano Herbs Light . . . . . . . . . . . 4038 amiea med . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7105 AnazaoHealth Corporation . . . . . . . . . . . . . . . . . . . . 7055 AnteAge MD by Cellese . . . . . . . . . . . . . . . . . . . . . . 8021 Apex Energetics . . . . . . . . . . . . . . . . . . . . . . . . . . 9009 APS Pharmacy . . . . . . . . . . . . . . . . . . . . . . . . . . . 5093 APYX Medical . . . . . . . . . . . . . . . . . . . . . . . . . . . 1055 AQ Skin Solutions . . . . . . . . . . . . . . . . . . . . . . . . . 8037 Argentyn 23 by Natural-Immunogenics . . . . . . . . . . . . . 6042 Arterosil - Calroy Health Sciences . . . . . . . . . . . . . . . . 3066 Atcor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9059 Attix Pharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . 2046 Avacen NuLife Ventures . . . . . . . . . . . . . . . . . . . . . 5027 Ayumetrix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7044 Ayush Herbs Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . 7064 Bella Medical Products - The Perfect Derma Peel . . . . . . . 7084 Bella Sciences - KERACELL MD & NEUROTRIS . . . . . . . . 7063 Bellaire Industry / Mesopen . . . . . . . . . . . . . . . . . . . 3045 Belmar Companies . . . . . . . . . . . . . . . . . . . . . . . . . 5036 Bemer Group . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7101 Berkeley Life Nitric Oxide . . . . . . . . . . . . . . . . . . . . . 4046 Bio-Botanical Research, Inc. . . . . . . . . . . . . . . . . . . . 7021 Bioclinic Naturals . . . . . . . . . . . . . . . . . . . . . . . . . 9025 Biome Research / HF Labs . . . . . . . . . . . . . . . . . . . . 6085

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BioReset Network . . . . . . . . . . . . . . . . . . . . . . . . . 2071 BioSensor Laboratories Inc. . . . . . . . . . . . . . . . . . . . . 2014 Biosound Healing Therapy . . . . . . . . . . . . . . . . . . . . 9046 Bio-Tech Pharmacal, Inc. . . . . . . . . . . . . . . . . . . . . . 4043 Biotics Research Corporation . . . . . . . . . . . . . . . . . . 6013 BirdEye . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3092 Blu Room Enterprises LLC . . . . . . . . . . . . . . . . . . . . 4085 Blue Horizon International . . . . . . . . . . . . . . . . . . . . 2104 BodyLogicMD . . . . . . . . . . . . . . . . . . . . . . . . . . . 4026 Boiron . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7034 Boost Oxygen LLC . . . . . . . . . . . . . . . . . . . . . . . . . 9045 Boston Heart Diagnostics . . . . . . . . . . . . . . . . . . . . . 4071 BrainMaster Technologies Inc. . . . . . . . . . . . . . . . . . . 3061 BTL Industries . . . . . . . . . . . . . . . . . . . . . . . . . . . 9023 Calmoseptine, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . 3071 Canada RNA Biochemical Inc . . . . . . . . . . . . . . . . . . . 8048 Candela . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8066 Canfield Scientific, Inc. . . . . . . . . . . . . . . . . . . . . . . 6048 CAREstream America . . . . . . . . . . . . . . . . . . . . . . . 3084 Celebrity Entrepreneur . . . . . . . . . . . . . . . . . . . . . . 5097 Cell Science Systems . . . . . . . . . . . . . . . . . . . . . . . 7093 Cell Surgical Network . . . . . . . . . . . . . . . . . . . . . . . 1030 Cellular Medicine Association . . . . . . . . . . . . . . . . . . 7075 Celluma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1021 Central Drugs Pharmacy . . . . . . . . . . . . . . . . . . . . . 2027 Cerbo by MD HQ . . . . . . . . . . . . . . . . . . . . . . . . . 9013 Chi’s Enterprises Inc. . . . . . . . . . . . . . . . . . . . . . . . 5042 Chronobrands, Inc. . . . . . . . . . . . . . . . . . . . . . . . . 1020 Clinical Resolution Lab . . . . . . . . . . . . . . . . . . . . . . 7049 CNS Vital Signs . . . . . . . . . . . . . . . . . . . . . . . . . . 2091 Cognitive Clarity Inc. . . . . . . . . . . . . . . . . . . . . . . . 1061 College Pharmacy . . . . . . . . . . . . . . . . . . . . . . . . . 6038 Complete Medical Services . . . . . . . . . . . . . . . . . . . . 9036 Cosmofrance . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5091 CRE8 Pharmacy Group . . . . . . . . . . . . . . . . . . . . . . 4064 CryoConcepts . . . . . . . . . . . . . . . . . . . . . . . . . . . 6090 Crystal Clear Digital Marketing . . . . . . . . . . . . . . . . . . 6032 CS Health LLC . . . . . . . . . . . . . . . . . . . . . . . . . . . 8072 Curatronic Ltd . . . . . . . . . . . . . . . . . . . . . . . . . . . 3049 CUTERA, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6103 Cyrex Laboratories . . . . . . . . . . . . . . . . . . . . . . . . 3032 Daiwa by US Jaclean, Inc. . . . . . . . . . . . . . . . . . 4078, 7046 DaVinci Laboratories . . . . . . . . . . . . . . . . . . . . . . . 2042

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DayTwo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7091 Dermaka Skin Care . . . . . . . . . . . . . . . . . . . . . . . . 9047 Designs for Health . . . . . . . . . . . . . . . . . . . . . . . . . 2021 DHA Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . 8090 Diagnostic Solutions Laboratory . . . . . . . . . . . . . . . . . 2020 Direct Biologics . . . . . . . . . . . . . . . . . . . . . . . . . . 8102 DNALife . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9039 Doctor Multimedia . . . . . . . . . . . . . . . . . . . . 5074, 8055 Doctor.com . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3033 Doctor’s Data, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . 8026 Doctors Supplement Store . . . . . . . . . . . . . . . . . . . . 3064 DoseLogix / Topi-CLICK . . . . . . . . . . . . . . . . . . . . . 1058 Douglas Laboratories . . . . . . . . . . . . . . . . . . . . . . . 1024 Dr.Fuji / ACIGI . . . . . . . . . . . . . . . . . . . . . . . . . . . 3067 Driving Force Company . . . . . . . . . . . . . . . . . . . . . . 2101 Dunwoody Labs . . . . . . . . . . . . . . . . . . . . . . . . . . 1028 Dutch Test by Precision Analytical Inc. . . . . . . . . . . . . . 4021 Eclipse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7043 Element Nutrition Inc. . . . . . . . . . . . . . . . . . . . . . . . 3095 Elemis Corporation . . . . . . . . . . . . . . . . . . . . . . . . 7090 Elsevier . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1063 Emerson Ecologics . . . . . . . . . . . . . . . . . . . . . . . . . 4092 Empirical Labs . . . . . . . . . . . . . . . . . . . . . . . . . . . 8064 Empower Pharmacy . . . . . . . . . . . . . . . . . . . . . . . . 4079 Endothelix Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . 1060 ENDYMED Medical Inc. . . . . . . . . . . . . . . . . . . . . . . 6097 Eniva Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9037 EnRichedPRP . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9034 Enter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8104 Enzyme Science . . . . . . . . . . . . . . . . . . . . . . . . . . 2061 Epimorphy, LLC . . . . . . . . . . . . . . . . . . . . . . . . . . 4091 Epionce . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7032 Erchonia Corporation . . . . . . . . . . . . . . . . . . . . . . . 5065 Excite Medical - DRX9000 . . . . . . . . . . . . . . . . . . . . 4061 Flowerkist . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4093 Fotona . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1027 Fountain Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3037 Freedom Practice Coaching . . . . . . . . . . . . . . . . . . . 3094 Gainswave . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2037 Genova Diagnostics . . . . . . . . . . . . . . . . . . . . . . . . 5013 GenXovite LLC . . . . . . . . . . . . . . . . . . . . . . . . . . . 1049 Gethealthy.store . . . . . . . . . . . . . . . . . . . . . . . . . . 1039 Global Life Rejuvenation . . . . . . . . . . . . . . . . . . . . . 3043 Great Plains Laboratory . . . . . . . . . . . . . . . . . . . . . . 6039 Greska’s Carbon-60 . . . . . . . . . . . . . . . . . . . . . . . . 9042 GX Sciences . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3103 Hair Science Corporation . . . . . . . . . . . . . . . . . . . . . 9021 Hallandale Pharmacy . . . . . . . . . . . . . . . . . . . . . . . 3055 HansBiomed USA Inc. . . . . . . . . . . . . . . . . . . . . . . . 3074 Harbor Compounding Pharmacy . . . . . . . . . . . . . . . . . 9049 Hawaiian Moon . . . . . . . . . . . . . . . . . . . . . . 3060, 7071 Health & Beauty Connection . . . . . . . . . . . . . . . . . . . 3091 Hormone Therapy Centers of America . . . . . . . . . . . . . 4104 Hydurage Ltd. Plaxpot . . . . . . . . . . . . . . . . . . . . . . . 7094 I.M. DRIPBaR . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6061 ICA Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8032 Ideal Protein of America . . . . . . . . . . . . . . . . . . . . . 9015 i-Med LED, LLC . . . . . . . . . . . . . . . . . . . . . . . . . . 3070 Immunosciences Lab . . . . . . . . . . . . . . . . . . . . . . . 1047 ImprimisRx Pharmacies . . . . . . . . . . . . . . . . . . . . . . 4036 InBody . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4033 Incredible Marketing . . . . . . . . . . . . . . . . . . . . . . . 1056 Innergy Development . . . . . . . . . . . . . . . . . . . . . . . 5079

Innovation Compounding, Inc. . . . . . . . . . . . . . . . . . . 7079 Integrative Peptides . . . . . . . . . . . . . . . . . . . . . . . . 2087 Intelligent Bioenergetics, Inc. . . . . . . . . . . . . . . . . . . . 7074 International Peptide Society . . . . . . . . . . . . . . . . . . . 7037 Jigsaw Health . . . . . . . . . . . . . . . . . . . . . . . . . . . 3044 Kaqun Europe Zrt . . . . . . . . . . . . . . . . . . . . . . . . . 3096 Kashi Clinical Laboratories . . . . . . . . . . . . . . . . . . . . 6044 KBMO Diagnostics . . . . . . . . . . . . . . . . . . . . . . . . 2043 Keto-Mojo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9055 Kimera Labs, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . 5060 Las Vegas HEALS . . . . . . . . . . . . . . . . . . . . . . . . . 2100 Lasering USA . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3105 LeadingResponse . . . . . . . . . . . . . . . . . . . . . . . . . 4097 Legally Mine . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3027 LifeWave . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6091 LightStim . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3046 Lightwave Therapy . . . . . . . . . . . . . . . . . . . . . . . . 8020 Liquivida Lounge . . . . . . . . . . . . . . . . . . . . . . . . . . 9041 Living Younger Lifestyle Medicine . . . . . . . . . . . . . . . . 2044 LivOn Labs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6067 L-Nutra . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4007 LS PRO Systems . . . . . . . . . . . . . . . . . . . . . . . . . . 2047 Lutronic Global . . . . . . . . . . . . . . . . . . . . . . . . . . . 4100 MasterThreads USA . . . . . . . . . . . . . . . . . . . . . . . . 9032 McGuff Compounding Pharmacy Services . . . . . . . . . . . 4072 McGuff Medical Products . . . . . . . . . . . . . . . . . . . . . 4072 Med Results Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . 3063 MedEsthetics Magazine . . . . . . . . . . . . . . . . . . . . . . 8062 Medical Marketing Solutions . . . . . . . . . . . . . . . . . . . 2067 Medical Wave LLC. . . . . . . . . . . . . . . . . . . . . . . . . 4067 Medicore, Co. Ltd. . . . . . . . . . . . . . . . . . . . . . . . . . 2097 Medikhan International Inc. . . . . . . . . . . . . . . . . . . . 6092 Medithread LLC . . . . . . . . . . . . . . . . . . . . . . . . . . 7066 Meditime Co. Ltd. . . . . . . . . . . . . . . . . . . . . . . . . . 2038 Medizap LLC . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7092 MedPro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8086 Meridian Valley Lab . . . . . . . . . . . . . . . . . . . . . . . . 8033 Merit Pharmaceutical . . . . . . . . . . . . . . . . . . . . . . . 4037 Metagenics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6007 Microbiome Labs . . . . . . . . . . . . . . . . . . . . . . . . . 3009 Mind Body Matrix . . . . . . . . . . . . . . . . . . . . . . . . . 4048 Mito Q Ltd. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4047 Mitochondrial Rescue . . . . . . . . . . . . . . . . . . . . . . . 6047 Mushroom Science . . . . . . . . . . . . . . . . . . . . . . . . 7047 My Practice Connect . . . . . . . . . . . . . . . . . . . . . . . 5066 Mymycolab . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8100 Myos Rens Technology . . . . . . . . . . . . . . . . . . . . . . 2090 Natural Ophthalmics, Inc. . . . . . . . . . . . . . . . . . . . . . 3036 Natural Partners Fullscript . . . . . . . . . . . . . . . . . . . . 7060 Natural Stacks . . . . . . . . . . . . . . . . . . . . . . . . . . . 2036 Nature-Throid . . . . . . . . . . . . . . . . . . . . . . . . . . . 6071 Nelly De Vuyst . . . . . . . . . . . . . . . . . . . . . . . . . . . 6055 NeuroScience . . . . . . . . . . . . . . . . . . . . . . . . . . . 7095 NewuLife . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1040 NKMax America . . . . . . . . . . . . . . . . . . . . . . . . . . 1042 Novus Optimum . . . . . . . . . . . . . . . . . . . . . . . . . . 7042 NuMedica . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4073 Nu-Scripts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7102 NuSkin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2055 Nutrafol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6037 Olympia Pharmaceuticals | Olympia Pharmacy . . . . . . . . . 7033 Organicell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7065 Ortho Molecular Products . . . . . . . . . . . . . . . . . . . . 4027

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EXHIBITOR INDEX Oxy Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3021 PatientPop . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1015 PedsPal GPO . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5072 Pellecome LLC . . . . . . . . . . . . . . . . . . . . . . . . . . . 8074 pH Prescription . . . . . . . . . . . . . . . . . . . . . . . . . . 3090 Pharma Nord, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . 1038 Physician Compounding Alliance . . . . . . . . . . . . . . . . . 8038 Physician Lab Inc. . . . . . . . . . . . . . . . . . . . . . . . . . 2035 PhysioAge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9061 Pinpoint Payments . . . . . . . . . . . . . . . . . . . . . . . . . 9038 Plattr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7011 PlusCBD Oil by CV Sciences . . . . . . . . . . . . . . . . . . . 2079 Pneuma Nitric Oxide LLC . . . . . . . . . . . . . . . . . . . . . 3062 Podcasting and Video Made Easy . . . . . . . . . . . . . . . . 2088 Power2Practice . . . . . . . . . . . . . . . . . . . . . . . . . . 7027 Predictive Biotech, Inc. . . . . . . . . . . . . . . . . . . . . . . 7026 Premier Research Labs . . . . . . . . . . . . . . . . . . . . . . 2060 Prestige Products Direct/TriadAer . . . . . . . . . . . . . . . . 9043 Professional Health Products . . . . . . . . . . . . . . . . . . . 8096 PromoItalia LLC . . . . . . . . . . . . . . . . . . . . . . . . . . 3097 PRO-PELL PELLET THERAPY . . . . . . . . . . . . . . . . . . 5061 Protocol For Life Balance . . . . . . . . . . . . . . . . . . . . . 8043 PULS Cardiac Test . . . . . . . . . . . . . . . . . . . . . . . . . 6033 Pulse Centers . . . . . . . . . . . . . . . . . . . . . . . . . . . 8078 Pure Encapsulations . . . . . . . . . . . . . . . . . . . . . . . . 1026 Purity Coffee . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6074 Purium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7061 Qest, LLC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8035 Qualgen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1064 Quest Diagnostics - Cleveland HeartLabs . . . . . . . . . . . .5090 Quicksilver Scientific . . . . . . . . . . . . . . . . . . . . . . . 5021 Rapid Release Technology LLC . . . . . . . . . . . . . . . . . . 5070 Rebel Herbs . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2085 ReeLabs Private Limited . . . . . . . . . . . . . . . . . . . . . 7104 Refine USA LLC . . . . . . . . . . . . . . . . . . . . . . . . . . 7085 Regenative Labs . . . . . . . . . . . . . . . . . . . . . . . . . . 9026 Regenerate Joy . . . . . . . . . . . . . . . . . . . . . . . . . . . 3073 RegenLab . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7070 Regul8 Pty Ltd. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3081 Rejuvenation Science . . . . . . . . . . . . . . . . . . . . . . . 4039 Relax Saunas of Momentum . . . . . . . . . . . . . . . . . . . 8084 Relief Gun . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9035 RemedeMD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6046 Renovacell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3093 Researched Nutritionals . . . . . . . . . . . . . . . . . . . . . 2039 Resync LLC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8046 Rhein Consulting Laboratories . . . . . . . . . . . . . . . . . . 5044 Riordan Technologies . . . . . . . . . . . . . . . . . . . . . . . 2015 RxLoupes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1050 RXQ Compounding . . . . . . . . . . . . . . . . . . . . . . . . 5064 Sana Botanicals . . . . . . . . . . . . . . . . . . . . . . . . . . 4096 SBA Loan Group . . . . . . . . . . . . . . . . . . . . . . . . . . 2063 Sciton, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4032 seca . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7039 selphyl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1048 ShangHaiShiDuo biological Technology company . . . . . . . 4065 Software TRT . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7096 Sovereign Laboratories . . . . . . . . . . . . . . . . . . . . . . 3078 Specialty MED Training . . . . . . . . . . . . . . . . . . . . . . 2033

130

ANNUAL WORLD CONGRESS

Spectracell . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8015 Standard Process Inc. . . . . . . . . . . . . . . . . . . . . . . . 6079 Stellar Biomolecular Research . . . . . . . . . . . . . . . . . . 4080 Styku . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7097 Sun Genomics, Inc. . . . . . . . . . . . . . . . . . . . . . . . . 5075 SunFlora Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9051 Synca Wellness . . . . . . . . . . . . . . . . . . . . . . . . . . .1062 TA Sciences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5007 TailorMade Compounding . . . . . . . . . . . . . . . . . . . . 7011 Tanita Corporation . . . . . . . . . . . . . . . . . . . . . . . . . 3075 Taymount Clinic . . . . . . . . . . . . . . . . . . . . . . . . . . 8089 Terra Biological LLC . . . . . . . . . . . . . . . . . . . . . . . . 4070 The Anthos Group . . . . . . . . . . . . . . . . . . . . . . . . . 9027 Theragun . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7036 TheraPellET . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1034 Thermi . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7086 TheWonderSpray . . . . . . . . . . . . . . . . . . . . . . . . . 1044 THOR Photomedicine . . . . . . . . . . . . . . . . . . . . . . . 6043 Tigovit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7062 Toolbox Genomics . . . . . . . . . . . . . . . . . . . . . . . . . 8105 Trocar Supplies . . . . . . . . . . . . . . . . . . . . . . . . . . . 8034 Tru Niagen - ChromaDex . . . . . . . . . . . . . . . . . . . . . 6094 U.SK Under Skin . . . . . . . . . . . . . . . . . . . . . . . . . . 2073 Uforia Sciences, LLC . . . . . . . . . . . . . . . . . . . . . . . . 8070 Ulta Lab Tests . . . . . . . . . . . . . . . . . . . . . . . . . . . 4060 UnCraveRx . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1043 Unipharma LLC . . . . . . . . . . . . . . . . . . . . . . . . . . .8009 University Compounding Pharmacy . . . . . . . . . . . . . . . 6021 US Biotek Laboratories . . . . . . . . . . . . . . . . . . . . . . 3039 Venus Concept . . . . . . . . . . . . . . . . . . . . . . . . . . . 7073 Vibrant America . . . . . . . . . . . . . . . . . . . . . . . . . . 7100 Vidya Herbs Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . 6060 Vielight Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9020 Viora . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5092 Virtual Health Partners . . . . . . . . . . . . . . . . . . . . . . 1057 Vita Aid Professional Therapeutics . . . . . . . . . . . . . . . .8042 Vitafor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6073 Vital Nutrients . . . . . . . . . . . . . . . . . . . . . . . . . . . 2045 Vital USA Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1035 VitaminLab . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2065 Viveve, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3079 ViviscalPRO . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1046 WAVI Co. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1066 Weave . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3047 WebToMed . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5047 WellConnect . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7103 Wellness USA . . . . . . . . . . . . . . . . . . . . . . . . . . . 2081 Wells Pharmacy Network . . . . . . . . . . . . . . . . . . . . . 4015 Women’s International Pharmacy . . . . . . . . . . . . . . . . 9033 WorldHealth.net . . . . . . . . . . . . . . . . . . . . . . . . . . 2102 XOStem, Inc. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6095 XYMOGEN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2075 Y Lift . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5033 ZHITTYA Genesis Medicine Inc. . . . . . . . . . . . . . . . . . 5046 Zimmer MedizinSystems . . . . . . . . . . . . . . . . . . . . . 6064 Zingit Solutions . . . . . . . . . . . . . . . . . . . . . . . . . . 4095 ZRT Laboratory . . . . . . . . . . . . . . . . . . . . . . . . . . 7005 Zycal Bioceuticals Healthcare Co., Inc. . . . . . . . . . . . . . 8060 Zyto . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1033

ANTI-AGING MEDICAL NEWS

• WINTER 2018

27TH

ANNUAL WORLD CONGRESS

EXHIBITOR LISTINGS A Hemp World

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Booth #3042

17775 N. 66th Lane, Glendale, AZ, 85308, US Ph: (602) 931-9526 • Fax: (903) 636-4051 Email: dana@ahempworld.com • Website: www.ahempworld.com A Hemp World was established in 2014. Since then, our mission is bringing value to those who have tried multiple avenues for health issues concerning pain, mental health, neurological health, internal and external inflammation, etc. A Hemp World is known to develop relationships with our customers so we can work on holistic health instead of sending people on their way because now is the time to take charge of your own health!

Absolute Pharmacy

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Booth #2048

16011 N. Nebraska Ave. Suite 103, Lutz, FL, 33549, US Ph: (813) 999-2700 Email: info@absoluterx.com • Website: www.Absoluterx.com At Absolute Pharmacy, we love innovating by delivering the finest pharmaceutical experience with high quality products, fastest turn around time and excellent customer service. Our Board Certified Pharmacists work in an ISO Class-5 CleanRoom with technologically advanced equipment, being USP-797 Compliant. By leveraging our superior technology, expert staff and FDA-Approved chemical. We provide customized medications meeting your specifications and expectations. We specialize in Anti-Aging, Peptides, Weight Management, HRT, IV therapy, Dermatology, Hair loss, and more.

AC Grace Company

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Booth #3038

PO Box 570, Big Sandy, TX, 75755, US Ph: (903) 636-4368 Email: info@acgrace.com • Website: www.acgrace.com AC Grace Company provides a line of Vitamin E products for whole health support and specific condition needs.

UNIQUE E® branded: Mixed Tocopherols Concentrate, Annatto Tocotrienols, Natural Moisturizing Cream, Derma Cream, Omega Krill Oil and Omega E+ (for cardiovascular support) formulated in collaboration with Dr. Mark Houston, along with AquaE® - a water-soluble E, and IronUP™ - a grape flavored product for children.

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Access Medical Laboratories

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Booth #4042

5151 Corporate Way, Jupiter, FL, 33458, US Ph: (866) 720-8386 • Fax: (866) 610-2902 Email: sales@accessmedlab.com • Website: www.accessmedlab.com Access is the Nation’s Premier Specialty Lab. We offer a broad menu of testing from blood, saliva and urine samples. Our ultra-automated facility delivers results to our clients within 24hrs and offers a tailored, personalized service experience.

AccuVein, Inc.

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Booth #4090

3243 Rt 112, Building 1, Suite 2, Medford, NY, 11763, US Ph: (888) 909-8888 Email: hello@accuvein.com • Website: www.accuvein.com AccuVein vein visualization technology helps improve aesthetic procedures by providing better vein visibility. AccuVein’s non-contact, lightweight and portable device provides a visual road map of the patient’s vasculature on the surface of the skin. The ability to visualize a patient’s unique anatomy facilitates vein avoidance to help minimize bruising during injectable procedures.

Accuview Imaging

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Booth #4045

PO Box 722, PO Box 722, Clark, CO, 80428, US Ph: (970) 870-7945 Email: contact@accuviewImaging.com • Website: www.accuviewimaging.com Excellent photo solution for the face, body, abdomen & leg treatments. Detailed and consistent/reproducible quality photos. Easy to take, view, and use for accurate images for websites, marketing, & proof of procedures A unique cloud-based system allows you to view your secure images from any computer, iPad, smart phone or PDA. Exclusive software measures circumferentially and areas for quantifiable changes in stomach, arms, thighs and chin. AccuView Imaging is the leader in photo excellence.

Acella Pharmaceuticals

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Booth #3100

1880 McFarland Pkwy., Ste.110, Alpharetta, GA, 30004, US Ph: (404) 483-4750 Email: info@acellapharma.com • Website: www.acellapharma.com Founded in 2007, Acella Pharmaceuticals is committed to accelerating health care solutions by bringing quality, affordable products to customers and patients. Since inception, we have added more than 40 products to our portfolio. Our current product portfolio delivers treatment that address medical needs in key therapeutic categories including: cough & cold, dermatology, injectables, hypothyroidism, nutritional supplementation, pain relief, and women’s health.

ADigital Health Guide

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Booth #6027

1016 Clare Ave., Ste. 5, West Palm Beach, FL, 33401, US Ph: (561) 247-3839 Email: a4m@yourhealthmail.com • Website: www.a4m.com/digital-health-guide.html Increase practice profitability and improve patient outcomes by managing patient care, education and support from virtually any location with our digital health guidance platform and app. Deliver protocol information for lifestyle modification, chronic illness, diet, exercise, mindfulness and more. Then track compliance, biometrics, activity, messaging and more in real time-- all private labeled and customizable for your practice. Patients love it and you will too. Manage patient care virtually anywhere with A Digital Health Guide.

Advice Media

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Booth #8044

PO Box 982064, Park City, UT, 84098, US Ph: (801) 367-7001 Email: sales@advicemedia.com • Website: www.advicemedia.com Advice Media has been a leader in Digital Marketing since 1998. As a client, you can have confidence knowing that this isn’t our first rodeo. When you engage Advice Media, you’re gaining a full team to support your business. The Advice Media team is comprised of designers, developers, programmers, writers, editors, search engine visibility specialists, digital marketing experts, Google-certified paid search experts, social media experts, email marketing experts, and support personnel working together to deliver the most comprehensive solutions available today.

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ANTI - AGING MEDICAL NEWS • WINTER 2019

Aerodiagnostics

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Booth #1052

561 Virginia Road, Suite 100, Concord, MA, 01742, US Ph: (617) 608-3832 • Fax: (617) 860-6617 Email: customerservice@aerodiagnostics.com • Website: www.aerodiagnostics.com Aerodiagnostics was founded on the principles of customer service and convenience. We offer convenient non-invasive hydrogen and methane breath collection kits that can be used in the comfort of your patients home or place of employment. Our goal is to provide you with highly accurate tests in a collection environment that is convenient.

Aesthetic Management Partners

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Booth #2054

2492 Walnut Ave., Ste. 120, Tustin, CA, 92780, US Ph: (877) 267-2670 Email: marindah@ampgrowth.net • Website: www.aestheticmanagementpartners.com We believe in starting with the patient first. Then we source innovative technology to deliver the absolute best outcomes. Delivering optimum results is the key to growing your practice. When you achieve exceptional patient outcomes, your practice will thrive. Our team carefully curates a portfolio of technologies that keep your practice at the cutting-edge of science and patient demand. We focus on safety and efficacy so you can focus on excellent clinical outcomes.

Aesthetics Biomedical Inc.

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Booth #5094

4602 N 16th St., Suite 300, Phoenix, AZ, 85016, US Ph: (602) 682-6841 • Fax: (602) 682-6841 Email: sales@aestheticsbiomed.com • Website: www.aestheticsbiomedical.com Aesthetics Biomedical is committed to the development and distribution of innovative aesthetic devices, products, and services for the global market. We create novel patient treatment experiences that ensure our products yield desired results, keeping patient comfort in mind. We also deliver state-of-the-art training to guarantee the best possible outcomes for providers and patients.

AgelessLX

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Booth #8036

135 W. Main Street, Ste. B, Missoula, MT, 59802, US Ph: (833) 337-9355 Email: hello@agelesslx.com • Website: www.AgelessLX.com AgelessLX® – Differentiate your practice with healthy aging nutritional products and a proven turn-key lifestyle intervention. AgelessLX® develops innovative nutritional products and patient-focused lifestyle programs that deliver optimal healthy aging outcomes for clinical offices. Our expertly produced programs provide an immersive lifestyle intervention coupled with patented, proven nutritional product support.

AgelessLX® products promote high compliance and deliver a functional, safe and effective solution for optimal ‘healthy aging’ for the health of your patients and practice.

Agnes Medical

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Booth #3072

2390 Crenshaw Blvd., Ste.804, Torrance, CA, 90501, US Ph: (844) 811-1154 Email: jroh@iagnes.com • Website: www.iagnes.com Agnes Medical is an aesthetic medical device manufacturer from South Korea and owned by a dermatologist, Gun Ahn, M.D. Dr. Ahn is a Korean dermatologist with over 20 years of clinical experience and research in the field of cosmetic dermatology. His passion for finding a ‘cure’ for acne has led to the development of the AGNES RF, which has now become a backbone technology in facial sculpting procedures in global Aesthetic Medicine.

Allergy Research Group

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Booth #8027

2300 North Loop Rd., Alameda, CA, 94502, US Ph: (800) 545-9960 • Fax: (800) 688-7426 Email: info@allergyresearchgroup.com • Website: www.allergyresearchgroup.com Since 1979, Allergy Research Group® and Dr. Stephen Levine have led the nutritional supplement industry, formulating the highest quality hypoallergenic, innovative, and unique new products.

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Alletess Medical Laboratory

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Booth #2032

14 Howard Street, Rockland, MA, 02370, US Ph: (800) 225-5404 • Fax: (781) 871-4426 Email: alletess@foodallergy.com • Website: www.foodallergy.com Alletess Medical Laboratory has provided allergy and immunology testing services to healthcare practitioners worldwide since 1980. We offer food allergy/sensitivity testing, inhalant allergy testing, mold exposure profiles, as well as panels for autoimmune disorders. We are committed to providing the best test performance and unsurpassed laboratory testing services to our clients. Our state of the art analyzers enables us to provide a quick turnaround and maintain competitive pricing. Visit us today to find out more.

American Biotech Labs

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The first step... Alletess

Booth #5043

705 E 50S, American Fork, UT, 84003, US Ph: (801) 361-5900 Email: sales@ablsilver.com • Website: www.silverbiotics.com American Biotech Labs provides an extremely unique form of nano-silver that out-performs colloidal silvers and other silver technologies and is used in a wide variety of ways. ABL sells liquid immune system supplements, cosmetic gels, dental/oral products, moisturizing skin creams, throat lozenges, facial serums (new!), and FDA 510k cleared Wound Dressing Gels. The company continues to research, develop, and manufacture products with the end goal of blessing the lives of people worldwide.

American Herbal Labs & Nano Herbs Light

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Booth #4038

8526 E. Garvey Ave, Rosemead, CA, 91770, US Ph: (626) 307-0928 Email: dr.luke@newvita.com • Website: www.newvita.com We offer a simple & effective system which is Artificial Intelligence in Chinese Medicine™. It includes Meridian Energy Analysis, Nano Herbs, Nano Vita Water and acupuncture without needles---Nano Herbs Light. One-day training class and book “CHINESE MEDICINE MADE SIMPLE” are available.

Dr. Luke Cua will provide TCM service on site.

AnazaoHealth

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Booth #7055

5710 Hoover Blvd., Tampa, FL, 33634, US Ph: (800) 995-4363 ext. 1520 Email: emarketing@anazaohealth.com • Website: www.anazaohealth.com AnazaoHealth is a full-service nationwide compounding pharmacy, with both a 503A Traditional Pharmacy and a 503B FDA-Registered Outsourcing Facility. We provide patient-specific and office-use preparations that are not commercially available for Aesthetics, Age Management, HRT, Men’s and Women’s Health, Mesotherapy, Urology, Vitamin Injectables, Weight Management and more.

AnteAGE MD

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Booth #8021

18218 West McDermutt, Suite A1, Irvine, CA, 92614, US Ph: (949) 419-4153 Email: ian@cellese.com • Website: www.anteage.com AnteAGE MD is a cosmeceutical product line harnessing the power of Bone Marrow Stem Cells. We’ve decoded the biosignal language these cells use to manage skin health at the cellular level. The right mix of these biosignals, called Growth Factors & Cytokines, can create a natural, youthful healing response at the deepest level. Research-proven, clinically-tested products include skincare, microneedling adjuncts, hair rejuvenation treatment, laser post-care, and vaginal rejuvenation solutions.

Apex Energetics

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Booth #9009

16592 Hale Ave., Irvine, CA, 92606, US Ph: (800) 736-4381 • Fax: (800) 323 1640 Email: tim@apexenergetics.com • Website: www.apexenergetics.com For over 25 years, Apex Energetics™ has served the healthcare community by sponsoring cutting-edge functional medicine education and offering an innovative portfolio of research-guided nutritional formulas.

Our unique approach to nutrition involves capturing and integrating science and healthcare practitioner insights into successful performance-based health strategies for patients. At Apex Energetics you and your patients are at the center of everything we do. ™

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APS Pharmacy

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Booth #5093

34911 US Highway 19 N #600, Palm Harbor, FL, 34584, US Ph: (727) 787-4137 Email: cs@apsmeds.com • Website: www.myapsmeds.com Our mission is to support patients’ health with quality, customized medications that are safe, reliable, and affordable. APS works with our healthcare partners, physicians and patients, to accomplish this mission. APS prepares sterile and nonsterile medications “from scratch” to meet individual needs.The 11,000-square-foot APS facility is compliant with USP nonsterile, sterile, and hazardous compounding guidelines. The pharmacy is licensed to dispense prescriptions in 49 states and Puerto Rico.

APYX Medical

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Booth #1055

5115 Ulmerton Rd., Clearwater, FL, 33760, US Ph: (727) 803-8627 Email: customerservice@apyxmedical.com • Website: www.apyxmedical.com Apyx Medical (formerly Bovie Medical) is an advanced energy technology company with a passion for elevating people’s lives through innovative products in the cosmetic market. Known for our Renuvion® Cosmetic Technology we’re focused on one thing: bringing transformative solutions to the customers we serve. Visit us at booth #1055.

AQ Skin Solutions

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Booth #8037

340 Goddard, Irvine, CA, 92618, US Ph: (949) 698-9649 Email: info@aqskinsolutions.com • Website: www.aqskinsolutions.com AQ Skin Solutions Inc, is a California (USA) based company specialized in the production of patented Growth factors (GF) based products. GF-technology refers to AQ’s advanced, cutting edge methods of producing human growth factors and utilizing them in topical skin, hair, and vaginal care products.

Growth factors (GF) are a group of specialized proteins with many functions, the most important being the activation of cellular functions leading to cellular rejuvenation, healing, and regeneration.

Argentyn 23 by Natural-Immunogenics

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Booth #6042

7504 Pennsylvania Ave, Sarasota, FL, 34243, US Ph: (888) 328-8840 • Fax: (941) 702-6101 Email: aalesteam@n-incorp.com • Website: www.sovereignsilver.com Since 2001, Argentyn 23 has offered health care practitioners a strategic immune-enhancing alternative devoid of toxic side effects and contraindications. Made from the purest silver (99.999%) and pharmaceutical-grade water, Argentyn 23 Bio-Active Silver Hydrosol is composed of more than 98% positively-charged silver ions and nanoclusters. It is only packaged in nonreactive glass bottles at a verified concentration of 23 parts-per-million. Argentyn 23 represents the ultimate refinement of the colloidal silver category and offers your patients unmatched safety, efficacy and purity in a professional formulation.

Arterosil - Calroy Health Sciences

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Booth #3066

11445 E. Via Linda, Scottsdale, AZ, 85259, US Ph: (602) 432-1992 • Fax: (602) 432-1992 Email: support@arterosil.com • Website: www.arterosil.com Arterosil® is a patent-pending nutraceutical that rebuilds the endothelial glycocalyx — the protective “nonstick” lining of the arteries. Preliminary results from a human pilot study indicate that Arterosil therapy results in reduction of atherosclerotic carotid plaque and a corresponding decrease in arterial stenosis, as demonstrated by reduction in lipid-rich necrotic core and increase in artery lumen size. Based on the promising initial findings, a larger multicenter vulnerable plaque regression study is currently being designed.

AtCor

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Booth #9059

515 Shuman Blvd., Ste. 515, Naperville, IL, 60563, US Ph: (630) 228-8874 • Fax: (815) 366-5953 Email: dtk@atcormedical.com • Website: www.atcormedical.com AtCor developed and markets SphygmoCor® technology, the global gold standard for central blood pressure waveform analysis and arterial stiffness assessment. SphygmoCor pulse wave analysis provides information that helps physicians better characterize cardiovascular risk and individualize treatment decisions. SphygmoCor is used by clinicians, researchers and pharmaceutical companies worldwide. Please also visit atcormedical.com or email info@atcormedical.com.

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Avacen NuLife Ventures

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Booth #5027

7052 Partridge Place, 7052 Partridge Place, Carlsbad, CA, 92011, US Ph: (760) 421-8255 Email: williamsickert50@gmail.com • Website: www.nulifeventures.com/billsickert AVACEN is an FDA Cleared Class Two medical device with published clinical studies for pain, fibromyalgia, autism, and microcirculation. Clinical Trials continue through UCSD VA Medical Center and San Diego State University. The product is marketed through NuLife Ventures. Both AVACEN and NuLife Ventures are based in the USA.

Ayumetrix

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Booth #7044

17387 63rd Ave, Lake Oswego, OR, 97035, US Ph: (503) 344-1344 Email: skapur@ayumetrix.com • Website: www.ayumetrix.com Ayumetrix is a “smart lab of the future” and has been founded to empower individuals to take charge of their health and wellness using innovative sample collection and laboratory testing technologies. It is a global functional testing laboratory that partners with clinicians all around the world and offers a practice building package that is inclusive of integrative and functional laboratory testing services, personal health data acquisition/ analysis-all under the guidance from industry experts.

Ayush Herbs Inc.

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Booth #7064

2239 152nd Ave. NE, Redmond, WA, 98052, US Ph: (425) 637-1400 • Fax: (425) 451-2670 Email: customerservice@ayush.com • Website: www.ayush.com Ayush Herbs is a family-owned company designed for physicians and dedicated to combining modern medical science with the ancient wisdom of Ayurveda. Our herbs are grown in the pristine valleys at the base of the Himalayas and are USDA certified organic. We use exhaustive in-house and third-party testing to ensure that we provide only the purest herbal products. Our formulations were created by the Sodhi brothers, Ayurvedic and Naturopathic physicians, and have been validated by 30 years of clinical use.

Bella Medical Products - The Perfect Derma Peel

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Booth #7084

8383 Wilshire Blvd., suite 1024, Beverly Hills, CA, 90211, US Ph: (310) 982-2777 Email: maggie@theperfectdermapeel.com • Website: www.theperfectdermapeel.com Founded by Nafeh Sebai, Bella Medical Products is dedicated to formulating innovative, result oriented skin solutions for the aesthetic medical industry. The Perfect Derma™ Peel debuts a new era in skin health.

It’s the only medical grade chemical peel that features Glutathione. Glutathione is the ultimate antioxidant with powerful skin lightening and anti-aging benefits. Peel provides healthy, ageless skin for all skin types and ethnicities.

Bella Sciences Logo_Keracell_AM_Neurotris.pdf

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Bella Sciences - KERACELL MD & NEUROTRIS

9:43 AM

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Booth #7063

410 Everna Street, Ste. 813, West Palm Beach, FL, 34401, US Ph: (352) 362-3173 Email: info@BellaSciences.com • Website: www.BellaSciences.com KERACELL MD Clinical Skin & Hair Revitalization Systems formulated for Pre and Post Procedure Recovery for Medical/Med Spa Treatments. Compliments PRP/Laser/Hair Grafting/Micro-Needling.

Ideal for Sensitive Skin and those who demand the BEST Skin and Hair Care Systems available. Gentle, Powerful, Soothing. Full Back Bar helps you build a full Medical & Luxury Medical Spa Treatment Menu for your clientele. Neurotris Micro-Current Systems for face and body treatments, featuring Micro, Pico, and Nano signatures. Demos Daily.

Bellaire Industry/Mesopen

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Booth #3045

11 Heather Ct, Middle Island, NY, 11953, US Ph: (631) 924-2751 Email: info@bellaireindustry.com • Website: www.bellaireindustry.com Bellaire Industry provides quality skin care equipment for medical and aesthetic professionals throughout the world. Our objective is to supply innovative devices that are effective, reliable, and user-friendly. We carry powerful microneedle and micropigmentation devices that are designed to withstand heavy usage in busy practices. Our newest machines are the radio frequency auto injection needling system for PRP treatments and microneedling with RF function.

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Belmar Companies

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Booth #5036

231 Violet Street, Suite 140, Golden, CO, 80401, US Ph: (800) 525-9473 • Fax: (866) 415-2923 Email: pharmacy@belmarpharmacy.com • Website: www.belmarpharmacy.com Belmar Companies specializes in dosage forms for BHRT. What sets us apart is our unique BLA™ (Bioavailable Lymphatic Absorption) lipid matrix tablet system designed for oral HRT; our exclusive parabenfree, petroleum-free hormone cream base; true sublingual tablets; and our outstanding customer service and value. We also compound Low-Dose Naltrexone, acetyl-glutathione, oxytocin, and custom amino acid and mineral blends. Belmar Select Outsourcing is our 503B Outsourcing Facility for hormone pellet implants.

Bemer Group

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BELMAR COMPANIES

Booth #7101

1112 Montana Ave #123, Santa Monica, CA, 90403, US Ph: (800) 273-2010 Email: BrilliantDNA@me.com • Website: www.caiti-cardinal.bemergroup.com BEMER isthe Ultimate Anti-Aging technology. Since 1998, it is the most researched and scientifically proven PEMF device in the world. Its patented waveform strongly enhances microcirculation, thus flooding body cells with more oxygen, ATP, nutrient absorption and waste removal. This reduces pain and inflammation, and strengthens fitness, immunity, collagen, hormonal balance, and youthfulness in body and skin. BEMER is FDA-registered, used by NASA, 4,000 doctors worldwide, and over a million very happy consumers.

Berkeley Life Nitric Oxide

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Booth #4046

PO Box 11347 355 East Ohio St, Suite 200, Chicago, IL, 60611, US Ph: (773) 750-7745 Email: info@berkeleylifeprofessional.com • Website: www.berkeleylifeprofessional.com Berkeley Life Professional Supplements help support Nitric Oxide levels for a healthy cardiovascular system. Our supplements deliver the bioactive nutrients found in nitrate-rich, plant-based diets to enhance our body’s production of Nitric Oxide. Optimal levels of Nitric Oxide are associated with cardiovascular health and an active lifestyle.

Bio-Botanical Research, Inc.

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Booth #7021

PO Box 2499, Aptos, CA, 95001, US Ph: (800) 775-4140 Email: questions@biocidin.com • Website: www.biocidin.com Celebrating 30 years of helping physicians address infections naturally, Bio-Botanical Research® provides healthcare professionals with broad-spectrum botanical formulations designed to assist those with GI dysbiosis, biofilms, oral, and systemic immune challenges. Our products have a significant impact on health, offering a valuable alternative to standard therapies by supporting the elimination of pathogens both orally and throughout the body. We offer free educational resources and personalized training to assist practitioners in clinical practice. www.biocidin.com 800.775.4140

Bio-Tech Pharmacal, Inc.

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Booth #4043

3481 N. Hwy. 112, Fayetteville, AR, 72704, US Ph: (800) 345-1199 Email: customerservice@bio-tech-pharm.com • Website: www.biotechpharmacal.com Bio-Tech Pharmacal, Inc., provides premium nutrition at the cellular level. Bio-Tech was established in 1984, is a cGMP registered / FDA registered nutraceutical (dietary supplements) manufacturer specializing in innovative high quality hypoallergenic preventative healthcare products, shipped to physicians, clinics, hospitals and pharmacies worldwide. Bio-Tech Pharmacal has over 100 research affiliations including Mayo, Cleveland, Emory, Harvard, etc. Bio-Tech Pharmacal has introduced many innovative products including D350,000 IU available in a water soluble delivery form. Some products are Kosher/Halal certified.

Bioclinic Naturals

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Booth #9025

2000 Brigantine Drive, Coquitlam, BC, V3N 4T6, CA Ph: (604) 421-1752 • Fax: (844) 384-7503 Email: customercare@assurednatural.com • Website: www.bioclinicnaturals.com Natural health pioneer, Dr. Joseph Pizzorno with fellow naturopathic physician and author, Dr. Michael T. Murray collaborated with Canada’s leading functional food manufacturer to develop the ultimate professional line -- Bioclinic Naturals. Bioclinic Naturals’ commitment is to quality; pure, potent, tested and trusted products. Made in Canada, GMP, TGA (Australia) and USP certified. Call 1.877.433.9860/www. bioclinicnaturals.com.

ANTI - AGING MEDICAL NEWS • WINTER 2019

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Biosound Healing Therapy

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Booth #9046

21955 U.S. 19 N, Clearwater, FL, 33765, US Ph: (888) 495-1946 Email: melody@biosoundhealing.com • Website: www.biosoundhealing.com Biosound Technologies has pioneered an innovative therapeutic solution for Health & Wellness Providers, First Responders, Chiropractors and Addiction Treatment Providers which integrates Brain Entrainment, Biofeedback Vibroacoustic Massage - Guided Imagery – Therapeutic Music and Sound Healing. The combination of vibrations and choreographed music typically produces a theta brainwave state in most people in 10 to 15 minutes.

Demonstration Biosound®Therapy sessions will be available throughout the conference.

Biotics Research Corporation

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Booth #6013

6801 Biotics Research Dr., Rosenberg, TX, 77471, US Ph: (800) 231-5777 • Fax: (281) 344-0725 Email: ·biotics@bioticsresearch.com • Website: www.bioticsresearch.com Biotics Research is a family owned and operated company that has helped revolutionize the dietary supplement industry by “Utilizing the Best of Science and Nature to Create Superior Nutritional Supplements.” We have developed a biologically active vegetable culture base, which is produced from organic non-soy legumes, and contains measurable amounts of trace minerals, antioxidant enzymes and phytonutrients. Our products supply true, whole-food, non-yeast forms of these elements, without common allergens such as wheat, soy and dairy.

Blu Room Enterprises LLC

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Booth #4085

Blu Room Enterprises LLC, 14507 Yelm Highway SE, Yelm, WA, 98597, US Ph: (360) 458-5230 Email: info@bluroom.com • Website: www.bluroom.com What is the value for a clinician? The Blu Room is an adjunct to medical treatment that helps patients in despair be uplifted, those in pain be relieved, and those depressed and stressed be transformed into a tranquil peaceful state of being. The Blu Room atmosphere supports physical, emotional, and spiritual wellbeing in our patients’ healing journey. That is the closest to the idealistic calling of healing that medicine is all about. Come try it for yourself!

BodyLogicMD

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Booth #4026

PO Box 971051, Boca Raton, FL, 33497, US Ph: (561) 972-9529 • Fax: (877) 457-1564 Email: dastern@bodylogicmd.com • Website: www.join.bodyLogicmd.com “Founded in 2003, BodyLogicMD makes up the nation’s largest network of the most highly-trained practitioners specializing in integrative medicine and bioidentical hormone replacement therapy. *The average BodyLogicMD network practitioner only needs to conduct 262 hours of patient-facing care to earn the median salary of U.S. physicians and surgeons. BodyLogicMD and practitioners of the network have been featured on Oprah.com, Fox News, and Dr. Oz, among other media outlets. Figures derived from BodyLogicMD’s *Franchise Disclosure Document issued April 29, 2019 and the 2018 U.S. Bureau of Labor Statistics Occupational Outlook Handbook”

Boiron

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Booth #7034

6 Campus Blvd., Newtown Square, PA, 19073, US Ph: (610) 325-8327 • Fax: (800) 999-4373 Email: info@boironusa.com • Website: www.boironusahcp.com Boiron, world leader in homeopathic medicines, is best known for its pharmaceutical grade-quality drugs such as its Arnicare® line of pain relievers and Oscillococcinum® flu reliever. Founded in 1932, Boiron is the largest pharmaceutical company in its home country of France. With subsidiaries in 19 countries, Boiron distributes products in more than 50 countries in categories such as analgesics, cough, cold, flu, first aid, baby and children’s, oral and eye care, indigestion, and women’s health.

Boost Oxygen LLC

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Booth #9045

92 Woodmont Road, Milford, CT, 06460, US Ph: (203) 331-8100 Email: info@boostoxygen.com • Website: www.boostoxygen.com Boost Oxygen, LLC is based in Milford, Connecticut, and is the leading manufacturer of portable, lightweight, 95% pure, Aviator’s Breathing Oxygen canisters. It is used by people visiting high altitude locations, professional and amateur athletes, senior citizens, and famous celebrities alike. Founded in 2007, Boost Oxygen made in America and is the best selling and most trusted oxygen canister brand in the world.

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JOIN.BodyLogicMD.com

Make More. Work Less. Gain Support.

Practitioners Supporting Practitioners

“

One of my favorite things about being part of BodyLogicMD is what we call our ‘brain trust.’ All of our practitioners are in constant contact supporting each other with answers to challenging clinical questions, sharing new research and being part of a community that truly functions as an extended family as well.

—Dr. Jennifer Landa Chief Medical Officer, BodyLogicMD

”

Franchise Owner, BodyLogicMD of Orlando, FL

See Us at Booth #4026 BodyLogicMD is a turn-key solution exclusively for top-level practitioners who are looking to maximize their practice revenue and personal time while gaining clinical support from a network of practitioners with over 15 diverse board certifications and specializations.

More Means More with BodyLogicMD... Revenue. Support. Time.

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Cash-Based Medicine

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Administrative Support

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Active and Passive Revenue

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Sales and Marketing Support

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Practitioner Brain Trust

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More Time for Personal Endeavors

Please Come Visit Us at Booth #4026 or Contact Deborah Astern for More Information.

Email: dastern@BodyLogicMD.com | Phone: 561-425-9912 | Website: JOIN.BodyLogicMD.com © 2019 BodyLogicMD Franchise Corp. All rights reserved. This information is not intended as an offer to sell, or the solicitation of an offer to buy, a franchise. It is for information purposes only. Currently, the following states regulate the offer and sale of franchises: California, Hawaii, Illinois, Indiana, Maryland, Michigan, Minnesota, New York, North Dakota, Oregon, Rhode Island, South Dakota, Virginia, Washington, and Wisconsin. If you are a resident of or want to locate a franchise in one of these states, we will not offer you a franchise unless and until we have complied with applicable pre-sale registration and disclosure requirements in your state. This advertisement is not an offering. An offering can only be made by a prospectus filed first with the Department of Law of the State of New York. Such filing does not constitute approval by the Department of Law. The franchisor, BodyLogicMD Franchise Corp., is located at 4850 T-Rex Avenue, Suite 125, Boca Raton, Florida 33431, and is registered as File Number F-6930 in the state of Minnesota. BLMD-A4M-FP-AD-2019-07-17

LEADERS IN SEXUAL WELLNESS DEDICATED TO YOUR SUCCESS

Are you looking for a proven revenue stream to grow your practice? GAINSWave® is the most renowned and respected trademark in shockwave therapy for treating ED. Implement our turnkey solution and you’re on your way to better serving your patients and growing your practice.

GAINSWave Provider Benefits Include: • Access to a network of medical experts • A premium brand consumers ask for by name • Patient lead generation • Tons of regularly updated marketing materials • Nationwide public relations & advertising • Brand exposure from top social media influencers • Optimized directory listing • Exclusive patented methodology

Come visit our booth #2037 for a special offer and we will show you how easy it is to get started!

Did you know that select GAINSWave providers are currently involved in the world’s largest clinical registry study that examines the role of low-intensity shockwave therapy for ED? The Shockwave Erectile Enhancement Trial (S.W.E.E.T.) is under way, and aims to ensure clinical excellence, best practices and quality standards within the GAINSWave medical community.

Visit JoinGAINSWave.com

Call (855) 383 - 5779

Boston Heart Diagnostics

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Booth #4071

175 Crossing Blvd., Ste.550, Framingham, MA, 01702, US Ph: (774) 424-8318 • Fax: Email: customercare@bostonheartdx.com • Website: www.bostonheartdiagnostics.com Boston Heart Diagnostics is focused on the treatment and prevention of disease by offering novel diagnostics that drive a personalized approach to improve patient health.

BrainMaster Technologies, Inc.

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Booth #3061

195 Willis St., Bedford, OH, 44146, US Ph: (440) 232-6000 • Fax: (440) 232-7171 Email: billm@brainm.com • Website: www.brainmaster.com A single source manufacturer of QEEG and neurofeedback medical devices. We are proud to introduce the All New Freedom 24D, 20D, 10D Dry, Wireless EEG brainwave Headset. This headset is compatible with previous Brain Mapping, QEEG analysis, and training, that may enable the prevention and/or reversing of cognitive decline, while encouraging mental fitness, memory improvement and self-improvement for your clientele.

BTL

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Booth #9023

362 Elm Street, Marlboro, MA, 01752, US Ph: (866) 285-1656 Email: info@btlnet.com • Website: www.bodybybtl.com BTL has grown to become one of the world’s major manufacturers of medical and aesthetic equipment.

With over 1,900 employees located in more than 53 countries, BTL has revolutionized the way to offer the most advanced non-invasive solutions for body shaping, skin tightening & other medical aesthetic treatments, including women’s health and wellness. BTL Aesthetics’ brands include EMSCULPT, BTL Emsella, EMTONE, BTL Vanquish ME, BTL Exilis ULTRA, and BTL Cellutone.http://bodybybtl.com.

Calmoseptine, Inc.

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Booth #3071

16602 Burke Lane, Corporate Address, Huntington Beach, CA, 92647, US Ph: (714) 840-3405 Email: info@calmoseptine.com • Website: www.calmoseptine.com Calmoseptine® Inc. promotes Calmoseptine® Ointment for the prevention and treatment of skin irritations from moisture such as urinary and fecal incontinence. It is also effective for irritations from perspiration, wound drainage, fecal & vaginal fistulas and feeding tube site leakage. Calmoseptine® Ointment temporarily relieves discomfort and itching. Free samples at our booth!

Canada RNA Biochemical Inc.

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Booth #8048

4400 Hazelbridge Way Unit 680, Richmond, BC, V6X 3R8, CA Ph: (604)273-2233 Email: info@canadarna.com • Website: www.canadarna.com We specialize in niche natural medicine for practitioners: 1. Boluoke™ (lumbrokinase), the most potent and best researched oral fibrinolytic agent hands-down; 2. CordImmune™ (Cordyceps sinensis), the only Cordyceps on the market that tests for and declares its cordycepin content; and 3. Corio-PSP™ (Coriolus versicolor), the best researched mushroom species for immune support. Remember to stop by our booth for a FREE coagulation health check ($85 value)!

Candela

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CRNA

Canada RNA Biochemical Inc.

Booth #8066

530 Boston Post Rd, Wayland, MA, 01778, US Ph: (949) 716-6670 Email: info@syneron-candela.com • Website: www.candelamedical.com/na Candela is a leading global aesthetic device company with a comprehensive product portfolio. The Company’s technology enables physicians to provide advanced solutions for a broad range of applications including body contouring, hair removal, tattoo removal, wrinkle reduction, and the treatment of vascular/ pigmented lesions, acne, leg veins and cellulite.

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Canfield Scientific, Inc.

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Booth #6048

4 Wood Hollow Road, Parsippany, NJ, 07054, US Ph: (973) 434-1201 • Fax: (973) 887-1249 Email: info@canfieldsci.com • Website: www.canfieldsci.com Canfield Scientific is the global leader in developing and distributing imaging systems for medical and skin care industries. Canfield’s advanced imaging solutions are used in surgical and non-surgical consultations to improve communications, align doctor-patient expectations and highlight results.

Cardiometabolic Health Congress

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Booth #1000

1801 North Military Trail, Suite 200, Boca Raton, FL 33431 USA Ph: 877-571-4700 • Fax: 866-218-9168 Email: info@cardiometabolichealth.org • Website: www.cardiometabolichealth.org The Cardiometabolic Health Congress (CMHC) is not only an annual conference or regional meeting. CMHC provides today’s health professionals with a focused point of access—designed to assist them in staying current with newly evolving scientific technologies. Cardiometabolichealth.org allows practitioners to learn about clinical advances, while receiving education in cardiometabolic disease prevention and treatment. Through its array of communications, CMHC provides an extensive educational platform, and delivers content to a brder audience of frontline clinicians: all of whom have a shared investment in cardiometabolic health.

CAREstream America

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Booth #3084

775 S. Northlake Blvd., Ste.1016, Altamonte Springs, FL, 32701, US Ph: (407) 960-2758 • Fax: Email: info@carestreamamerica.com • Website: www.carestreamamerica.com CAREstream America is the premier distributor of cutting-edge aesthetic and regenerative solutions.

Our innovative Pro-Nox is a 50/50 Nitrous Oxide and Oxygen analgesic for relief of procedure pain and anxiety without opioids. Our Body Jet line features the Evo/Eco for micronized fat transfer and gentle body contouring. Exosomes, Amniotic Fluid and PRFM are a few of our regenerative therapy options. Visit our website to view our complete portfolio, www.carestreamamerica.com.

Celebrity Entrepreneur

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Booth #5097

350 Fifth Ave. 59th Floor, New York, NY, 10118, US Ph: (212) 888-2999 • Fax: (702) 938-8618 Email: clint@clintarthur.tv • Website: www.clintarthur.tv Transforming Experts into Celebrities in the Eyes of Customers & Prospects

Cell Surgical Network

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Booth #1030

73700 Dinah Shore Drive Suite 301, Palm Desert, CA, 92211, US Ph: (310) 985-5894 • Fax: (760) 464-0388 Email: campaigns@cellsurgicalnetwork.com • Website: www.stemcellrevolution.com The Cell Surgical Network is the largest international team of physicians investigating the deployment of stromal vascular fraction (SVF, loaded with adipose derived stem cells) under IRB approved protocols. CSN Affiliates rely on an online HIPAA compliant database to collect patient information and follow ups to determine the safety and efficacy of each cell surgical procedure. CSN uses this data and published the largest safety data paper to date on the IV infusion of SVF.

Cellular Medicine Association

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Booth #7075

52 S. Section St., Ste.A, Fairhope, AL, 36532, US Ph: (888) 920-5311 Email: support@vampiremarketing.zendesk.com • Website: www.cellularmedicineassociation.org This group of scientists, physicians, and nurse-practitioners works to discover and become expert at the best uses of cell biology to improve health and beauty. The methods include stem cells, peptides, glycosaminoglycans, retinoic acid, platelet rich fibrin matrix, hormones, nutritional strategies, and cosmetic peels. http://vampirefacelift.com/members/workshops/

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Being the only cream on the market formulated by a functional pharmacist, the science behind MindBody Matrix is founded on the principle of Energy Medicine. Imprinted with bio-informational frequencies to help relieve minor aches and pains and alleviate the bodyâ&#x20AC;&#x2122;s energy blockages.

ARE YOU A PRACTIONER INTERESTED IN OUR MINDBODY MATRIX WHOLESALE OPTIONS? OUR STARTER KIT INCLUDES: SPECIAL PRICE (8) 120 ML FULL SIZE BOTTLES $453.15 (5) 30 ML TRAVEL SIZE BOTTLES BONUS VALUE $1157.00 (1) FREE 120 ML FULL SIZE BOTTLE SAVINGS $703.85 (1) FREE 30ML TRAVEL SIZE BOTTLE (10) FREE 16 ML SAMPLE SIZE BOTTLES

Central Drugs Pharmacy

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Booth #2027

520 West La Habra Boulevard, La Habra, CA, 90631, US Ph: (877) 447-7077 Email: kathy@centraldrugsrx.com • Website: www.centraldrugsrx.com Central Drugs is an industry leader in the art and science of custom compounding and individualized health-care solutions with a team of expert pharmacists at our new 503B Outsourcing facility and stateof-the-art 503A compounding laboratories. Central Drugs is your pharmacy partner working with you and your team to provide resources, education, and services to improve the overall health of your patients.

Cerbo by MD HQ

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Booth #9013

5714 SE Powell Blvd., Ste.202, Portland, OR, 97206, US Ph: (888) 315-2642 Email: sales@md-hq.com • Website: cer.bo/try-cerbo Cerbo by MD HQ is a complete solution – EHR + Patient Portal + Practice Management – and the backbone of your thriving functional medicine practice. Enjoy flexible quick charting tools, markable charting templates, integrated supplements and inventory, tools for IV infusions and injections, whitelabeled Patient Portal with custom forms, merchant services, lab integrations (including with functional labs), and MUCH more, plus incredible configuration and support. Full demo available: cer.bo/try-cerbo.

Love your EHR!

Chi’s Enterprises Inc.

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Booth #5042

1435 N. Brasher St, Anaheim, CA, 92807, US Ph: (714) 777-1542 Email: chimailing@gmail.com • Website: www.chi-health.com For 33 years, Chi’s Enterprise offers supplements clearly defined mechanisms and backed by scientific studies, including ANGIOSTOP for anti-cancer and anti-aging demonstrating senolytic therapies. According to ScienceMag, May 17, 2019, Angiostop increases P53, BAD and BAX for cancer, eye diseases, neurodegeneration, atherosclerosis, etc. MYOMIN, an aromatase reducer is supported by Dr. Jonathan Wright in BHRT classes since 2010. Recommended for reducing estradiol and increasing testosterone. OXYPOWER reduces C-Reactive Protein/inflammation and improves heart, lungs and energy.

Chronobrands, Inc

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Booth #1020

3960 Howard Hughes Pkwy. Ste. #500, Las Vegas, NV, 89169, US Ph: (855) 247-6668 • Fax: (855) 660-9805 Email: info@chronobrands.com • Website: www.chronoceuticals.com

® ®

Chronobrands is a medical supplement company specializing in the science of chronobiology. As the manufacturer of the Chronoceuticals supplement line, Chronobrands offers a complete line of supplements that have been scientifically formulated to provide the optimal combination of nutrients at the right time of day in an effort to provide the most beneficial results. All of the Chronoceuticals supplements are pharmaceutical grade and manufactured with the highest quality standards.

Clinical Resolution Lab

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Booth #7049

1400 West Lambert Rd. Suite C, Brea, CA, 92821, US Ph: (213) 384-0500 Email: info@clinicalresolution.com • Website: www.skincarecrl.com Clinical Resolution Laboratory, Inc. (CRL) is a US medical device manufacturer and a full service product development laboratory serving wholesalers and skin care professionals. CRL is the sole developer of the InnoPen and MTS Roller, microneedling device both uniquely patented non-ablative skin treatment tools designed for use by professionals in skin health, drug delivery and hair restoration. Proudly made in the USA, we present the highest quality and safety in all our products.

CNS Vital Signs

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Booth #2091

598 Airport Blvd. Suite 1400, Morrisville, NC, 27560, US Ph: (888) 750-6941 Email: support@cnsvs.com • Website: www.cnsvs.com CNS Vital Signs is a world leader in computerized-neurocognitive assessment tools. Baseline, evaluate and track the status and disease progression of your patients. Used by over 12,000 clinicians and researchers in 52 countries including numerous functional and integrative medical experts! Available in over 50 languages with remote testing capability. Come by our exhibit or go to www.cnsvs.com for a free trial.

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Cognitive Clarity Inc

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Booth #1061

7500 212th St SW, Suite 214, Edmonds, WA, 98026, US Ph: (425) 678-8485 Email: sarahmosser@cognitiveclarityinc.com • Website: www.perceptabrain.com Cognitive Clarity Inc. develops breakthrough patented nootropics for the aging brain. Founded in 2015 by two of the world’s leading Alzheimer’s disease and brain aging researchers, Dr. Alan Snow and Dr. Rudy Tanzi. Percepta Professional is a landmark nutraceutical product consisting of patented PTI-00703 cat’s claw, MemorTea (a specific oolong tea extract) and black currant. These three ingredients have potent activity at inhibiting and reducing brain plaques, tangles and inflammation - the keys to improving memory loss in the aging brain.

College Pharmacy

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Booth #6038

3505 Austin Bluffs Pkwy., Ste.101, Colorado Springs, CO, 80918, US Ph: (719) 262-0022 ext. 171 • Fax: (800) 556-5863 Email: customerservice@collegepharmacy.com • Website: www.collegepharmacy.com Knowledge Changes Everything: Quality. Innovation. Experience. First established in 1974, it is College Pharmacy’s compounding process, attention to detail, and quality of the compounding components that continues to make our formulations exceptional. Our expertise includes: Specialty Injectables, IV Protocols, Environmental Medicine, Chelation, BHRT, Thyroid, Age Management, Aesthetic Medicine, and more. Visit our booth #730 or contact us directly to learn more about our comprehensive compounding services and practitioner resources.

Complete Medical Services

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Booth #9036

141 Pererk Ct. Ste D, Romeo, MI, 48065, US Ph: (586) 532-1142 • Fax: (586) 261-5105 Email: sverellen@completemedicalservices.com • Website: www.completemedicalservices.com Complete Medical Services has 22 years of experience working with Physician Offices and have the expertise to help you build your cash practice through patient health and wellness. We offer unique solutions with medical devices and products that will help patients achieve total body transformation and optimal health with a strong Return on Investment to your practice.

Cosmofrance

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Booth #5091

1444 Biscayne Blvd., Ste. 218, Ste. 218, Miami, FL, 33132, US Ph: (305) 538-0110 Email: contact@cosmofrance.net • Website: www.cosmofrance.net CosmoFrance inc. - established in 1997 in Miami FL - specializes in the import and distribution of medical devices designed exclusively for non-surgical aesthetic procedures. CosmoFrance manufactures & distributes the following products in the United States: The DermaSculpt® blunt-tipped microcannula. The Cosmopen® microneedling pen. ezPRF® Platelet-Rich Fibrin, and The Ultimate Blood concentrate.

CRE8 Pharmacy Group

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Booth #4064

3700 NW 126th Ave., , Coral Springs, FL, 33065, US Ph: (754) 529-8353 Email: communications@cre8pharmacy.com • Website: www.cre8pharmacy.com CRE8 Pharmacy offers compounding services for personalized medicine and patient-specific prescriptions. We are a team, working at creating formulations, dispensing orders reliably and resolving issues promptly. Specializing in Peptides, functional medicine and hormone replacement. Sterile & Non-Sterile compounds / Generic & Brand medications / Nutritional Supplementation with our own CRE8 Vitality Nutrition supplement line. Everything a patient needs is shipped in one simple order. Welcome to the future of compounding pharmacy.

Crystal Clear Digital Marketing

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PHARMACY

Booth #6032

5750 Major Blvd. Suite 500, Orlando, FL, 32819, US Ph: (407) 793-9254 Email: sales@crystalcleardm.com • Website: www.crystalcleardigitalmarketing.com Crystal Clear is the industry leader in providing world-class software, marketing and consulting solutions for the modern elective medical practice. Named “Top Aesthetic Service Provider 2016-2019” by Aesthetic Everything®, “Best Practice Marketing Company 2016-2017” by THE Aesthetic Guide, and ranked #210 on the Inc. 500 List of America’s Fastest-Growing Companies, Crystal Clear strives to help practices around the globe find, serve and keep more patients profitably through one fully-integrated system.

ANTI - AGING MEDICAL NEWS • WINTER 2019

147

CS Health LLC

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Booth #8072

1402 West Main Street, Lousiville, KY, 40203, US Ph: (502) 583-4402 • Fax: (502) 561-5505 Email: dsmith@caudillseed.com • Website: www.cs-health.com Providing processed seed extract in two forms, Vitalica-the first and original Sulforaphane Glucosinolate Supplement and Vitalica Plus, endogenous Myrosinase Enzyme-activated Dietary Supplement in regular and Physicians’ strength doses. In addition Broccoli Seed Oil is offered as a topical oil with that includes natural and stable Sulforaphane liquid. Body creams with encapsulated Sulforaphane powder is now offered at 1,3,5,& 10 percent strengths.

Curatronic Ltd

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, LL

Booth #3049

101 Hebron Road, Jerusalem, Yerushalayim, 9348001, IL Ph: (972) 2674-4080 Email: info@curatronic.com • Website: www.curatronic.com Curatronic is a leading innovator and manufacturer of PEMF [Pulsed Electro-Magnetic Field] therapy devices for a range of diseases, and wellness and anti-aging treatments. Tens of millions Curatron PEMF treatments have been done in 90 countries around the world. Curatronic has established itself as a supplier of very high quality and super reliable PEMF systems. R&D and manufacturing takes place in Israel where many high-tech innovations originate.

Cyrex Laboratories

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Booth #3032

2602 S. 24th Street, Phoenix, AZ, 85034, US Ph: (602) 845-1374 • Fax: (602) 845-1374 Email: michelle.c@cyrexlabs.com • Website: www.joincyrex.com Cyrex® is a clinical laboratory specializing in functional immunology. Cyrex offers multi-tissue antibody testing, and assessments of predictive antibodies to a variety of antigens, for the early detection and monitoring of today’s complex autoimmune conditions.

Daiwa by U.S. Jaclean, Inc.

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Booth #4078, 7046

1816 W., 135th ST., Gardena, CA, 90249, US Ph: (310) 538-2298 Email: tradeshows@usjaclean.com • Website: www.daiwamassage.com Established in 1982, based in Gardena, CA. We offer high quality health & wellness products.

Our best seller Daiwa by U.S. Jaclean, Inc.massage chair collection, sold nationwide & offered by businesses at airports & spas. We pride ourselves with great costumer service. We look forward to meeting you at the show!

Come by our booths & try our latest luxury massage chairs. You can also find us at www.massagechairs.com & www.facebook/daiwamassagechair.

DaVinci Laboratories of Vermont

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Booth #2042

929 Harvest Lane, Williston, VT, 05495, US Ph: (802) 878-5508 Email: bkanya@foodsciencecorp.com • Website: www.davincilabs.com For over 45 years, DaVinci® Laboratories has been a leader in nutritional research, product development and innovation from our home state of Vermont. Our dedication to higher integrity, and insistence on superior quality are a reflection of Vermont values. We are a family-owned and managed company and are always willing to assist you in any way possible on matters relating to nutrition. Every day, DaVinci® continues to set new standards for quality and product innovation so we can keep you as healthy and informed as possible.

Dermaka Skin Care Products

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Booth #9047

1257 SW Martin Hwy., Ste. 768, Palm City, FL, 34991, US Ph: (772) 266-3376 Email: info@dermaka.com • Website: www.info@dermaka.com Dermaka is an all-natural plant based cream enriched with vitamins that can be used on all types of skin disorders secondary to invasive procedures including post phlebectomy, sclerotherapy, chemical and laser peels.

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149

GET YOUR PATIENTS

BACK IN THE GAME Pulse Wave Therapy • Comfortable • Non-invasive • No Downtime Visit us at Booth

7043

#

“The eVive™ is great! I love it, my staff loves it, and my patients love it.”

– Dr. Robert Bowen Safe – Proven, efficacious treatment without the use of injections or oral medications.

Simple – Low maintenance, affordable and easy-to-use.

Real Results – High patient satisfaction of an affordable, comfortable therapy with no downtime.

Profitable– In-office treatment offers a more profitable solution with low acquisition cost, and an easy ROI.

For more information or to become a provider, contact Eclipse at 800.759.6876 or visit EclipseMed.com

EVIA4MAD Rev. 1

Designs for Health

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Booth #2021

980 South Street, Suffield, CT, 06078, US Ph: (860) 623-6314 ext. 2087 Email: info@designsforhealth.com • Website: www.designsforhealth.com In 1989, Designs for Health began as a family-owned company offering nutritional counseling and educational services with deep roots in natural medicine and functional nutrition. Three decades later, we have stayed committed to the integrity of our products, customer service, company operations, and family values. Through that commitment, Designs for Health has established itself as the leading innovator and fastest growing brand of high-quality nutritional supplements in the healthcare practitioner channel. With one of the largest and widest range of nutritional supplement lines, we are focused on successful patient treatment outcomes exclusively to health professionals.

Diagnostic Solutions Laboratory

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Booth #2020

31 Lupi Court Suite 250, Palm Coast, FL, 32137, US Ph: (877) 485-5336 • Fax: (470) 239-5017 Email: jeff.ingersoll@diagnosticsolutionslab.com • Website: www.diagnosticsolutionslab.com Diagnostic Solutions Laboratory is the leader in functional DNA testing. Our GI-MAP™ test is the only comprehensive stool analysis to offer quantitative polymerase chain reaction (qPCR) on bacteria, yeast, protozoa, and viral GI targets. Our latest innovation, GenomicInsight™, incorporates comprehensive SNP analysis with today’s most advanced artificial intelligence platform, Opus23 Explorer™.

DNALife

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Booth #9039

1 Cybercity, Ebene, 72201, MR Ph: (413) 344-7033 Email: hlepine@dnalife.healthcare • Website: www.dnalife.healthcare Until recently, healthcare practitioners have been left to educate themselves in this exciting area of clinical science; we recognise the complexities that surround DNA testing, and our goal is to make this science readily accessible to every clinical practice. We differentiate ourselves in the market through our extensive knowledge base, our selective test panels and our practical and user-friendly reports. Equipped with the most up-to-date DNA tests, DNALife is dedicated to providing healthcare practitioners with training and education to accurately interpret genetic results.

Doctor Multimedia

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Booth #5074, 8055

2765 Iverness Ct., La Jolla, CA, 92037, US Ph: (760) 668-3322 Email: Exhibits@doctormultimedia.com • Website: www.doctormultimedia.com We’re successful for one simple reason: no one can outwork us. At most, they can do the same, but they can’t do more. We’re open 24 hours a day, 7 days a week, 365 days a year. We have graphic designers, WordPress developers, social media masters, content creators, SEO wizards, IT problem solvers, marketing gurus, and all around ninjas ready to help your medical practice thrive and grow.

Doctor.com

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Booth #3033

85 5th Ave., New York, NY, 10003, US Ph: (203) 442-6376 Email: info@doctor.com • Website: www.doctor.com Doctor.com is the first marketing automation and reputation management platform purpose-built to help healthcare professionals build a thriving digital presence and enhance their online reputation.

Doctor’s Data, Inc.

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Booth #8026

3755 Illinois Ave., St. Charles, IL, 60174, US Ph: (630) 377-8139 • Fax: (630) 587-7860 Email: info@doctorsdata.com • Website: www.doctorsdata.com Doctor’s Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced, CLIA-licensed clinical laboratory since 1972. A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, hormone status, cardiovascular risk, liver and metabolic abnormalities, and more.

ANTI - AGING MEDICAL NEWS • WINTER 2019

FUNCTIONAL TESTING EXPERTS

151

Doctors Supplement Store

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Booth #3064

250 Axminister Drive, St. Louis, MO, 63026, US Ph: (877) 846-7122 • Fax: (877) 903-9290 Email: support@DSSOrders.com • Website: www.doctorssupplementstore.com Doctors Supplement Store will set up your personalized online dispensary to sell the quality supplements you recommend from over 300 professional brands. • Fast, FREE and easy setup – we do all the work! • Use EZScripts and Templates to send electronic recommendations. • Fast, accurate shipping and a popular and flexible Auto Ship program. You’ll love how we care for you and your patients – we call it Uncommonly Good Customer Service!

DoseLogix | Topi-CLICK

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Booth #1058

300 Parkbrooke Place, Suite 140, Woodstock, GA, 30189, US Ph: (877) 870-8448 Email: info@DoseLogix.com • Website: www.doselogix.com Topi-CLICK® by DoseLogix manufactures topical metered-dosing applicators that are accurate, innovative, and easy-to-use; which is the focus of every product design including the NEW TOPI-CLICK Micro® and the Perl® Vaginal Dosing Method. Visit booth #1058 for your FREE sample kit or request one at http:// doselogix.com/samples. We’ll also provide copies of the ARL Bio Pharma studies proving Topi-CLICK® is the most accurate topical dosing dispenser among those tested. Visit http://www.doselogix.com for product and ordering information.

by

Douglas Laboratories

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Booth #1024

112 Technology Drive, Pittsburgh, PA, 15275, US Ph: (800) 245-4440 Email: dlcusservice@atrium-innovations.com • Website: www.douglaslabs.com Douglas Laboratories® researches, develops and manufactures the right suite of rigorously designed, science-based, healthy aging supplements, and provides customized practice support. We push the potential of both clinical practices and patients to continually perform at their personal best, today and in the future.

Dr Fuji / ACIGI

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Booth #3067

4399 Ingot Street, Fremont, CA, 94538, US Ph: (510) 651-9088 • Fax: (510) 651-6188 Email: marketing@drfuji.com • Website: www.fujichair.com Dr. Fuji Cyber-Relax Health & Wellness massage equipment, is the fruit of further evolution of intelligent pneumatic and mechanical milt-technology designed to partner with medical and health professionals in their clinical stress managements.

Dunwoody Labs

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Booth #1028

9 Dunwoody Park Ste # 121, Dunwoody, GA, 30338, US Ph: (678) 736-6374 ext. 6010 • Fax: (770) 674-1701 Email: info@DunwoodyLabs.com • Website: www.dunwoodylabs.com Dunwoody Labs is an innovator of testing solutions that assist in the diagnosis and management of conditions commonly addressed by integrative medicine. Our unique profiles are designed to help practitioners address comprehensive approaches to patient care. We also offer educational programs to empower practitioners and patients.

Dutchtest by Precision Analytical Inc. TM

•

Booth #4021

3138 Northeast Rivergate, Suite 301C, McMinnville, OR, 97128, US Ph: (503) 687-2050 Email: info@dutchtest.com • Website: www.dutchtest.com Precision Analytical Inc. is improving global wellness by providing important insight into hormones and their function. Their state-of-the-art innovation in hormone testing uses the acronym DUTCH (Dried Urine Test for Comprehensive Hormones). Precision is now the world leader in hormone testing as their DUTCH™ test provides the most comprehensive look at hormones through simple collection and helps practitioners answer the most complex clinical questions. Lastly, DUTCH testing is built to optimize HRT monitoring.

152

ANTI - AGING MEDICAL NEWS • WINTER 2019

Eclipse

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Booth #7043

5916 Stone Creek Dr., Suite 120, The Colony, TX, 75056, US Ph: (703) 209-2698 Email: dkankam@eclipsemed.com • Website: www.eclipsemed.com Eclipse leads the market in innovation and is known for its portfolio of professional products such as their top-selling Eclipse PRP®. Additional offerings include: the eVIVE, Pulse wave therapy device, MicroPen Evo, micro-needling device, Theradome®, laser hair helmet, and other medical accessories.

Elemis Corporation

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Booth #7090

600 B Street Ste # 300, San Diego, CA, 92101, US Ph: (775) 297-4778 Email: sales@elemiscorp.com • Website: www.elemiscorp.com Elemis Corporation is a market leader and cutting-edge biomedical device company specializing in superior disposable trocar kits and reusable trocar sets. FDA Registered, ISO Compliant, and US designed. Our innovation focuses on providing precision instrumentation for physicians while delivering patient procedural comfort. Elemis offers an array of product solutions for training programs, compounding pharmacies and medical practioners. Experience firsthand the Elemis Edge: Quality, Comfort, and Flexibility.

Elsevier

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Rejuvenation Advanced

Booth #1063

1600 John F Kennedy Blvd Suite 1800, Philadelphia, PA, 19103, US Ph: (215) 239-3900 Email: m.fee@elsevier.com • Website: www.elsevierhealth.com Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, and deliver better care.

Empirical Labs

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Booth #8064

1501 Academy Ct. Ste # 5, Fort Collins, CO, 80524, US Ph: (970) 232-8970 Email: info@empirical-labs.com • Website: www.empirical-labs.com Empirical labs are celebrating 30 years of making brilliant products, we specialize in building unique delivery mechanisms. The products are formulated using only the best ingredients, coupled with our own great delivery systems. We started making liposomes some 12 yrs ago and now boast over 150 formulas. We offer B2C and B2B formulas and have been instrumental in breaking into new areas: Water SolubleCBD, Multivitamin Liposomals, our goal is to make marketing leading products.

Empower Pharmacy

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Booth #4079

5980 W. Sam Houston Pkwy. N. Suite 300, Houston, TX, 77041, US Ph: (281) 804-4499 • Fax: (832) 678-4419 Email: info@empowerpharmacy.com • Website: www.empowerpharmacy.com Empower Pharmacy is an FDA registered 503B Outsourcing Facility and a 503A Compounding Pharmacy that provides healthcare practitioners and patients with high-quality formulations and outstanding customer service. Our experienced pharmacists collaborate with patients and healthcare practitioners to provide innovative solutions for health and wellness. With state-of-the-art facilities that tout the latest cGMP equipment, cleanrooms, environmental controls, and professional staff, we are proud to be a leader in the compounding industry.

ENDYMED Medical Inc.

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Booth #6097

4400 Route 9 South, Freehold, NJ, 07728, US Ph: (732) 409-5148 Email: info@endymedusa.com • Website: www.endymed.com ENDYMED Medical offers energy based medical aesthetic treatment systems for both the professional and consumer markets. ENDYMED’s proprietary, FDA cleared 3DEEP®radiofrequency (RF) technology is a highly effective, superior solution for non-ablative wrinkle reduction, facial and body skin tightening and contouring, RF microneedling, fractional skin resurfacing, and acne and traumatic scar treatment. ENDYMED’s flexible platforms, with 7 unique treatment handpieces available, offer endless aesthetic treatment possibilities, and can grow as your practice expands.

ANTI - AGING MEDICAL NEWS • WINTER 2019

153

Eniva Health

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Booth #9037

2700 Campus Dr, Minneapolis, MN, 55441, US Ph: (260) 615-8057 Email: rswedzinsk@aol.com • Website: www.eniva.com 21 year old NSP certified developer, manufacturer and distributor of extremely high quality liquid nutraceuticals.

All products are domestically produced under strict GMP’s. No GMO’s, no artificial sweetners, no irradiation, cold processed, vegan friendly. Liquid minerals are our specialty. Our USP mineral elements are angstrom in size in a base of ultra-purified structured water (Dr Emoto) for maximum health impact and safety. The difference between truly water soluble minerals and all others (chelated, colloidal, etc) is profound.

EnrichedPRP

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Booth #9034

953 Franklin Avenue, Suite 200, Garden City, NY, 11530, US Ph: (844) 888-2418 Email: orders@EnrichedPRP.com • Website: www.enrichedprp.com EnrichedPRP offers one of the leading systems in therapeutic autologous biologics. The system is designed with the most current research, medical studies, and scientific data ensuring that our physicians have the best chance at optimizing the efficacy of their patients’ treatments. The EnrichedPRP system can perform six different processes giving it the flexibility and ease required when getting started. Please contact our offices so we can answer any questions you or your staff may have.

Enzyme Science

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Booth #2061

771 Commerce Dr., Venice, FL, 34292, US Ph: (941) 441-3781 • Fax: (941) 575-6310 Email: Orders@enzyscience.com • Website: www.enzyscience.com Enzyme Science™ represents exceptional solutions for digestive health and wellness. In addition, we offer unique enzyme blends formulated with vital nutraceuticals to support various health functions including cardiovascular, immune, and joint support. All materials used in production are from the most premium, high quality sources available. Enzyme Science™ spares no expense to make natural solutions that never contain binders, artificial fillers, or flow agents. This guarantees the purest supplements available that inspire confidence in their safety and effectiveness.

Epimorphy, LLC

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Booth #4091

3189 Red Hill Ave. Suite D, Costa Mesa, CA, 92626, US Ph: (833) 693-6243 Email: info@mydnage.com • Website: www.mydnage.com Epimorphy is a biotechnology company based in Costa Mesa, CA. Epimorphy focuses on understanding the role of epigenetics in human health. Epimorphy offers the myDNAge® test, the gold standard of the biological age prediction test. The test is based on Dr. Steve Horvath’s Epigenetic Aging Clock and utilizes Next Generation Sequencing technology to scan over 2,000 sites in the human genome in order to make the most accurate age prediction.

Epionce

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Booth #7032

10211 W. Emerald St., Boise, ID, 83704, US Ph: (866) 374-6623 • Fax: (866) 374-6603 Email: info@epionce.com • Website: www.epionce.com Developed by a dermatologist, physician-dispensed Epionce is an innovative skin wellness line designed to optimize the health of the skin by working with its own protective and reparative systems. Multiple independent clinical studies have proven the products are effective in helping to reverse and prevent visible skin aging and symptoms of skin diseases. Simple, effective and proven, Epionce is the ideal cosmeceutical line for anyone who desires optimally healthy, beautiful skin.

Offical Brand Specifications

Erchonia Corporation

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Booth #5065

650 Atlantis Rd., Melbourne, FL, 32904, US Ph: (888) 242-0571 Email: Info@erchonia.com • Website: www.erchonia.com Erchonia Corporation was founded in 1996 as a small family business, and even though we have grown into an international enterprise, we still operate under the founding principles that guided us to our present success. Our commitment to the legitimate advancement of low-level laser therapy (3LT®) through scientific and clinical research has transformed Erchonia into a world leader in the field of LLLT technology.

154

ANTI - AGING MEDICAL NEWS • WINTER 2019

SAY NO TO DRUGS.

FIRST & ONLY

LASER FDA CLEARED TO TREAT CHRONIC LOW BACK PAIN, CHRONIC HEEL PAIN & NOCICEPTIVE MUSCULOSKELETAL PAIN

SHOWCASING AT BOOTH #5065

INTRODUCING FX 635 For physicians looking for an opioid-free alternative treatment for lower back pain, heel pain & nociceptive musculoskeletal pain, laser therapy is proving to be a medical breakthrough with incredible results, no harmful side-effects and most promising of all, no potential for addiction.

NO DRUGS | NO SIDE EFFECTS | NO PAIN

(866) 551-7847 | erchonia.com

Thanks to Erchonia’s FX 635 Laser — the world’s first and only laser designed to relieve chronic and acute pain of the musculoskeletal origin — hands-free laser treatment for pain is now a reality.

Best of all, the FX 635 is FDA market cleared and proven to work without the need for invasive surgery or the potentially harmful prescription of opioids.

ENDOTHELIX THE ENDOTHELIAL FUNCTION COMPANY Vascular Reactivity Index (VRI)

Bring This Page to Booth 1060 to Receive $1000 Credit Toward Purchasing VENDYS-11 Incorporate endothelial function monitoring in your practice, enhance your patient care, and increase your bottom line by as much as $200,000 per year.

www.endothelix.com

www.endothelix.com

www.endothelix.com

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Flowerkist

•

Booth #4093

30211 Avenida De Las Banderas, 2nd Floor, Rancho Santa Margarita, CA, 92688, US Ph: (949) 766-6750 Email: info@flowerkist.com • Website: www.flowerkist.com Flowerkist is a luxe Cosmetic and Skin Care line that contains beneficial flower extracts and only the best ingredients. Our products have been formulated both with and without high quality, organic Hemp CBD so that we are able to provide both to our customers.

Fotona

•

Booth #1027

2307 Springlake Road, Suite 518, Dallas, TX, 75234, US Ph: (972) 598-9000 • Fax: Email: info@fotona.org • Website: www.fotona.com Fotona, celebrating 50 years of laser expertise and leadership, has sold over 25,000 lasers worldwide with distribution in over 60 countries. Fotona produces award winning lasers in dentistry, aesthetics, dermatology, gynecology, and surgery, leading the industry in quality, reliability, ease-of-use and durability. Fotona is dedicated to its motto, “Choose Perfection”.

Gainswave

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Booth #2037

2920 NE 207th St., Ste.901, Aventura, FL, 33180, US Ph: (305) 842-3293 • Fax: Email: team@gainswave.com • Website: www.joingainswave.com Why Choose GAINSWave? Consumers demand premium brands and it’s no exception when it comes to sexual health. GAINSWave® is the leader in shockwave therapy for male sexual enhancement and treating erectile dysfunction because it works. Our team of experts has created the premium brand consumers ask for by name 10 – 1! With our turnkey business solution, you’ll gain access to tons of valuable resources making it simple to implement treatment into your practice with continued future success. Keep your focus on caring for your patients and being the best at your craft – we’ll handle the rest.

Genova Diagnostics

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Booth #5013

63 Zillicoa St., Asheville, NC, 28801, US Ph: (828) 210-7362 Email: info@gdx.net • Website: www.gdx.net Genova Diagnostics is a leading clinical laboratory applying systems-based testing approaches to the diagnosis, treatment and prevention of complex chronic disease. Genova specializes in clinical laboratory services with actionable information.

GenXovite, LLC

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Booth #1049

5001 1st Ave., SE, ste 105 - PMB 322, Cedar Rapids, IA, 52402, US Ph: (319) 899-6595 Email: sunny.kim@genxovitepro.com • Website: www.genxovitepro.com Regenerative medicine is rapidly reshaping the face of health care. By 2020, this disruptive industry is projected to surpass orthopedic surgery. GenXovite, LLC was established to meet the growing needs of forward thinking practitioners seeking guidance in the field of regenerative medicine. From deciding which biologics or clinical protocols to use to dealing with real world business challenges, GenXovite, LLC aims to ease the learning curve and take your practice to the next level.

Gethealthy.store

•

Booth #1039

4131 Spicewood Springs I-4, Austin, TX, 78759, US Ph: (512) 318-7107 Email: meredith@gethealthy.store • Website: www.gethealthy.store GetHealthy.store is wellness eCommerce and marketing - redefined. In addition to eCommerce and integrative marketing services, GetHealthy.store offers 5 integrative health categories: food/nutrition, supplements, equipment, home, and personal care products. Your patients or clients choose from the products you hand-pick, and can even purchase your private labels! Lastly, we’ll work with you to market your store, including email campaign management and social media asset creation. Improve your lifetime value with GetHealthy.store!

ANTI - AGING MEDICAL NEWS • WINTER 2019

157

Global Life Rejuvenation

•

Booth #3043

161 E. Main St., Denville, NJ, 07834, US Ph: (973) 627-1750 • Fax: (973) 627-4158 Email: bharris@globalliferejuvenation.com • Website: www.globalliferejuvenation.com Leader in Anti-Aging Medicine, medical weight loss, practice development and patient education. Creating a national physicians network. Marketing each location, educating patients and scheduling appointments, connecting doctors to patients and patients to state-of-the-art compounding pharmacies.

Great Plains Laboratory

•

Booth #6039

11813 West 77th Street, Lenexa, KS, 66214, US Ph: (913) 341-8949 • Fax: (913) 815-4043 Email: rcochran@gpl4u.com • Website: www.greatplainslaboratory.com The Great Plains Laboratory, Inc. is a global leader in metabolic, environmental, and genetic testing for people with chronic diseases. We provide clients with access to the most reliable, comprehensive, and understandable scientific results using the latest technology and proven techniques to maintain optimal health for patients of all ages.

GX Sciences

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Booth #3103

4150 Freidrich Lane, Ste. H, Austin, TX, 78744, US Ph: (844) 258-5564 • Fax: Email: info@gxsciences.com • Website: www.gxsciences.com GX Sciences offers Nutrigenomic testing, micro sampling which includes an interpretation platform. Our customized software, is specifically designed for providers only and allows the provider to validate a patient’s specific nutritional needs, laboratory results, lifestyle recommendations and health precautions based on the patient’s individual DNA and blood findings. GX Sciences is designed to empower providers and patients with an easy-to-use, scientifically validated genomic and micro sampling platform to provide health and recovery through personalized nutrition

Hair Science

HAIR SCIENCE DEVELOPERS OF ADVANCED HAIR LOSS FORMULAS

•

Booth #9021

4711 N. Camino Real, Tucson, AZ, 85718, US Ph: (866) 558-1744 • Fax: Email: info@hairsciencecorp.com • Website: www.hairsciencecorp.com Hair Science is a pharmaceutical research and development company focused on bringing proven hair loss solutions to market in the United States. Out latest addition, Formula 82S, a 3-in-1 (shampoo + conditioner + anti-hair loss) product that leaves hair feeling soft, healthy and easy to comb—without the need for a separate conditioner—will be available at our booth (#9021). It is an excellent complement to a daily regrowth regimen, and a great general restorative shampoo for dry, thin and damaged hair.

Hallandale Pharmacy

•

Booth #3055

1109 E. Hallandale Beach Blvd., Hallandale, FL, 33009, US Ph: (954) 455-3822 Email: newaccounts@hallandalerx.com • Website: www.hallandalerx.com With our inception in 2004, Hallandale Pharmacy’s growth has been propelled by the increase in demands of custom medications. While quality is the foundation of our practice, our service to our patients and providers, drives our mission. We look forward to earning your trust. Discover for yourself why some of the leading doctors in the U.S. trust and use Hallandale Compounding Pharmacy for our reliability, service and prices.

HansBiomed USA Inc.

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Booth #3074

12016 Telegraph Rd., Ste.103, Santa Fe Springs, CA, 90670, US Ph: (562) 777-7043 Email: hansusa@hansbiomed.com • Website: www.mintpdo.com As the first Asian tissue bank approved by the US FDA, HansBiomed produces safe & high-quality allograft and medical device products in accordance with the US FDA, EATB, and AATB standards. Our FDA cleared, MINT PDO is a safe and effective thread for soft tissue approximation to a desired position. MINT PDO’s bidirectional & helically positioned barbs provide instant results with minimal pain and scarring and rapid recovery for patients.

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ANTI - AGING MEDICAL NEWS • WINTER 2019

Harbor Compounding Pharmacy

•

Booth #9049

2000 Harbor Blvd., Ste. C100, Costa Mesa, CA, 92627, US Ph: (714) 797-8356 • Fax: (949) 642-5039 Email: info@harborcompounding.com • Website: www.harborcompounding.com We are a full service pharmacy located in Costa Mesa, California, a coastal city in Orange County. Our specialty is personalized medication to help our patients achieve optimal health. We focus primarily on customized formulations of bioidentical hormone replacement therapy, but also specialize in compounded pediatric medicines, pain therapies, custom thyroid prescriptions, veterinary formulations, and dermatological preparations. Harbor Compounding is a PCAB certified pharmacy and a member of the BBB.

Hawaiian Moon

•

Booth #3060 7071

321 S. Missouri Ave., Clearwater, FL, 33756, US Ph: (727) 709-1484 • Fax: (866) 618-6480 Email: customerservice@hmaloe.com • Website: www.aloecream.biz

Say Goodbye to Dry Skin with Hawaiian Moon Organic Aloe Cream! It is free of dyes, fragrance, parabens, sulfates, mineral oil, and any other harsh chemicals, including petroleum. Our cream penetrates the skin up to 7 layers deep, and absorbs into the skin instantly.

Health and Beauty Connection

•

Hawaiian Moon, Inc.

www.AloeCream.biz

Booth #3091

2000 Harbor Blvd C-100, Costa Mesa, CA, 92627, US Ph: (949) 642-0106 Email: info@hnbc.us • Website: www.harborcompounding.com Whole Body Vibration Therapy Ideal for All Ages, Lifestyles and Physical Abilities. You merely step onto the platform, you can stand, sit, lie down, or even focus the platform on specific body parts. The platform creates a vibration, which is sent through the body. In reflex the muscles contract. This causes tendons to stretch and increases blood flow and improved blood oxygenation. This strengthens and tones without effort on the person’s part. since the vibrations get sent through the entire body, all the muscle groups are affected.

i-Med LED, LLC

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Booth #3070

880 W. Main St., Lansdale, PA, 19446, US Ph: (267) 205-9172 Email: 168medicalclinic@gmail.com • Website: www.imedled.com iMED LED, LLC produces Red/NIR Light Therapy products including Dr. Erik’s iBox and iBed for whole body biophotomodulation(BPM). We also make PRP kits and Centrifuges for RPR clinics.

I.M. DRIPBaR

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Booth #6061

250 Centerville Rd, Warwick, RI, 02886, US Ph: (401) 921-5934 • Fax: (401) 921-5936 Email: shannon@im-120.com • Website: www.im-dripbar.com I.M. DRIPBaR Franchise; IV business opportunity for Medical Professionals and 797 compliant. Lead by Dr. Stephen Petterutti, I.M. DRIPBaR is positioned to grow via the strongest foundation in this cash-based business that provides incredible patient value. The Franchisor provides you with the needed business development, training, on-going support, and marketing so that you can focus on your clients and the bottom line. Now is the time to join the most powerful team in IV therapies.

Ideal Protein of America

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Booth #9015

3135 SR 580, Safety Harbor, FL, 34695, US Ph: (866) 314-4447 ext. 177 • Fax: (819) 772-0416 Email: businessdev@idealprotein.com • Website: www.idealprotein.com The Ideal Protein Weight Loss Protocol is medically designed and developed and is consistent with evidencebased guidelines, to help obese and overweight patients or clients achieve safe, long-term weight loss and maintain it. The Protocol helps to reverse the imbalance in insulin that occurs with the typical Western diet and that contributes to weight gain and metabolic syndrome. Physicians report that after successful completion of the Ideal Protein Weight Loss Protocol, patients experience significant improvement in metabolic parameters.

Individualized, professional health coaching helps patients or clients learn proper nutrition and new eating habits.

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Booth #1047

822 S Robertson Blvd Suite 312, Los Angeles, CA, 90035, US Ph: (310) 657-1077 • Fax: (310) 657-1053 Email: immunsci@gmail.com • Website: www.immunoscienceslab.com

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Immunosciences Lab., Inc. (ISL) is a pioneer and leader in the field of clinical immunology. Licensed in California and certified by both CLIA and the College of American Pathologists, ISL was founded in 1989 and has specialized in developing unique immunological assays that have earned the lab a reputation that extends abroad. The research that went into the development of these tests has been published in the most prestigious medical journals in the field.

The recognition by these respected publications and the many U.S. patents awarded to Immunosciences Lab., Inc. is testimony to ISL’s more than two decades of expertise and in-depth understanding of clinical immunopathology.

I. S . L .

ImprimisRx Pharmacies

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Booth #4036

12264 El Camino Rd., Suite 350, San Diego, CA, 92130, US Ph: (858) 704-4048 Email: jcaldwell@imprimisrx.com • Website: www.imprimisrx.com ®

ImprimisRx is dedicated to delivering high-quality and innovative compounded medications from FDARegistered or PCAB-Accredited Facilities. We work with physicians and patients to provide access to alternative compounded medicines at affordable prices. The efficiency of our business model allows us to quickly innovate and deliver high quality medications at low costs. Visit www.imprimisrx.com to learn more

InBody

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Booth #4033

13850 Cerritos Corporate Dr., Cerritos, CA, 90703, US Ph: (562) 306-5960 ext.411 • Fax: (323) 952-5009 Email: convention@inbody.com • Website: www.inbody.com Since 1996, InBody has made one of the most accurate and precise DSM-BIA devices. Used by professionals in the anti-aging, regenerative and functional medicine fields, InBody devices provide a holistic approach to preventing and treating disease. In less than 60 seconds, InBody Tests produce outputs like Visceral Fat Analysis, Percent Body Fat and BMR. These outputs can set more effective treatment plans, predict outcomes and accurately assess your clients’ health status. To learn how an InBody can benefit your practice, visit www.InBody.com.

Incredible Marketing

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Booth #1056

25361 Commercentre Drive Ste 100, Lake Forest, CA, 92630, US Ph: (800) 949-0133 Email: sales@incrediblemarketing.com • Website: www.incrediblemarketing.com Since 2008, we’ve helped over 500 medical practices build barriers against competition and commoditization by parlaying their offline experience into online authority. Gain more patients without giving away profits. You can have both. We can help.

Innergy Development

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Booth #5079

215 S Mountainland Dr., Orem, UT, 84058, US Ph: (801) 903-2747 Email: info@innergydev.com • Website: www.innergydev.com Innovative Non-Invasive Technologies For many years we have been working to develop products and services that best serve the people. Innergy Development prides itself in manufacturing the best quality, most innovative non-invasive technologies available today. With minds like Albert Einstein, Nikola Tesla and Dr. Royal Rife something amazing was sure to develop and now we’re making it available to you!

Innovation Compounding, Inc.

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Booth #7079

6095 Pine Mountain Rd. NW Suite 108, Kennesaw, GA, 30152, US Ph: (800) 547-1399 • Fax: (866) 635-2329 Email: info@innovationcompounding.com • Website: www.innovationcompounding.com Innovation Compounding is a wellness-based, PCAB-accredited, compounding-only pharmacy that takes an integrative approach to meeting our patients’ and providers’ needs. We support over 7,000 prescribers and annually provide 70,000 prescriptions across the nation. We’re here to listen to you, research your needs, and provide you not only with medications, but also the knowledge to help your patients reach their desired health goals.

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Integrative Peptides

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Booth #2087

555 W 5th Street, Los Angeles, CA, 90013, US Ph: (888) 699-4150 Email: info@integrativepeptides.com • Website: www.integrativepeptides.com Integrative Peptides was born out of the idea that there had to be a better way for patients and their healthcare providers to gain access to safe peptide supplements. Physicians interested in peptides are currently limited to high priced options or risky, unvetted overseas or research only suppliers. Enter Integrative Peptides, founded in 2018 with one purpose: to offer over a peptide supplement that meets the highest standards of quality, safety, and value.

Intelligent Bioenergetics, Inc.

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Booth #7074

317 El Camino Real, Ste.407, Encinitas, CA, 92024, US Ph: (858) 539-6111 • Fax: (866) 319-1361 Email: info@intellbio.com • Website: www.IntellBio.com Intelligent Bioenergetics Advanced Microcurrent, for those who demand the best in pain management.

International Peptide Society

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Booth #7037

4737 N Ocean Dr, #132, Ft. Lauderdale, FL, 33308, US Ph: (859) 619-9760 • Fax: Email: support@peptidesociety.org • Website: www.peptidesociety.org The International Peptide Society (IPS) was founded to advance the research and practice of the clinical use of Peptides. At IPS we share the commitment to sound scientific principles and evidence-based medicine, we encourage research and development in these fields to complement therapeutic strategies. Our mission is to promote Peptide education and improve these groundbreaking technologies safely and ethically, in order to better patients’ outcomes and lives.

Jigsaw Health

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Booth #3044

9035 E. Pima Center Pkwy, Suite 3, Scottsdale, AZ, 85258, US Ph: (888) 352-5050 Email: help@jigsawhealth.com • Website: www.jigsawhealth.com We believe in Air, Water, Magnesium... Nearly 80% of the population is deficient in Magnesium. And we believe the reason is due to lack of education on what Magnesium does and its essential role in the body. So we’ve made it our mission to provide Magnesium “edu-tainment” -- entertaining educational content as well as provide a solution with our magnesium supplements designed to reduce muscle cramps and improve your energy and sleep.

Kashi Clinical Laboratories

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Booth #6044

10101 SW Barbur Blvd., Portland, OR, 97219, US Ph: (877) 879-1815 • Fax: (503) 206-6939 Email: vsimonis@kashilab.com • Website: www.kashilab.com Kashi Clinical Laboratories is a fully-accredited clinical laboratory that specializes in a range of genomic healthcare services from HLA testing for Bone Marrow Transplants to UA toxicology/drug testing and genetic health panel testing. Kashi Lab offers a distinctive one-on-one approach in developing laboratory testing services to meet organization and project requirements. We promote well-being and quality of life by delivering the highest standard of laboratory work because we recognize our service as more than a test result.

KBMO Diagnostics

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Booth #2043

4 Business Way, Hopedale, MA, 02332, US Ph: (617) 933-8130 • Fax: (617) 933-7660 Email: Info@kbmodiagnostics.com • Website: www.kbmodiagnostics.com KBMO Diagnostics is a fully integrated medical diagnostics company offering multi-pathway food sensitivity testing. Using the Food Inflammation Test (FIT) panel, KBMO measures up to 132 foods, colorings and additives. We provide a color-based report, meal plan and mobile app access for each patient. We also offer the Zonulin Test for gut permeability. Our recent IBS Clinical Study shifted KBMO from Biological Plausibility to Clinical Efficacy, a Gold Standard in laboratory testing.

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Keto-Mojo

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Booth #9055

952 School Street, Ste. 212, Napa, CA, 94559, US Ph: (707) 312-0946 Email: groove@keto-mojo.com • Website: www.keto-mojo.com Keto-Mojo produces a state-of-the-art blood testing meter and strips, an essential tool to measure, manage, and maintain optimal health. The meter is rated #1 by The Diet Doctor, providing accuracy, accessibility, and affordability for those following the ketogenic lifestyle. We are committed to working with Health Professionals to assist you in the critical work you provide. Visit our professional portal https://keto-mojo. com/pages/professional-portal for a variety of partnering opportunities, including wholesale, affiliate, and academia options.

Kimera Labs, Inc.

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Booth #5060

2831 Corporate Way, Miramar, FL, 33025, US Ph: (224) 254-0956 Email: adamkoster@kimeralabs.com • Website: www.kimeralabs.com Kimera Labs Inc. is a biotechnology company that develops perinatal exosome products for research and therapeutic purposes. Since 2012, Kimera Labs has invested significant resources into exosome isolation and therapy protocols. As a regenerative medicine focused biotechnology company, Kimera Labs develops therapies that heal from within. By providing regenerative cellular signals under the control of messenger and miRNA, we believe it is possible to initiate the healing processes that can benefit patients of any age.

L-Nutra

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Booth #4007

8322 Beverly Blvd., Los Angeles, CA, 90048, US Ph: (310) 467-1960 Email: aperez@l-nutra.com • Website: www.l-nutra.com Recent breakthrough science has uncovered the power of fasting as a way to optimize the body’s aging process and disrupt chronic diseases such as obesity, diabetes, cancer, autoimmune disorders, Alzheimer’s and cardiovascular disease. Our mission is to educate the world about the health benefits of fasting and introduce it back into the human diet in a safe and effective way via the Fasting Mimicking Diet (FMD).

LeadingResponse

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Booth #4097

4805 Independence Parkway, Suite 250, Tampa, FL, 33634, US Ph: (813) 885-8267 Email: marketinginfo@leadingresponse.com • Website: www.leadingresponse.com BETTER PROSPECTS. BETTER RESULTS.

LeadingResponse has marketed more than 1,000,000 consumer seminars for financial advisors. Our SeminarSuccess® program is now being successfully utilized by medical practices looking to attract more large fee-based cases. Practices utilizing our program are consistently filling 3-6 events with 30 affluent and pre-screened attendees per event. Our targeted approach is fueled by millions of responder records and prior local event data to give you an edge in your area.

Legally Mine

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Booth #3027

1337 E 750 N, Orem, UT, 94097, US Ph: (801) 890-6930 • Fax: (888) 801-6454 Email: braxton@legallymineusa.com • Website: www.legallymineusa.com Medical professionals have unfortunately become all too easy targets for MANY trial attorneys! Legally Mine will teach you how to protect your medical license, guard against frivolous lawsuits, and save money on taxes. A small investment of your time and attention will pay a lifetime of dividends and keep more of the money you earn right where it belongs--IN YOUR POCKET.

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LifeWave

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Booth #6091

9202 W. Behrend Dr., Peoria, AZ, 85382, US Ph: (520) 403-5076 Email: drjoan9@gmail.com • Website: www.lifewave.com/hft LifeWave, Inc. is the owner of patented wearable, virtually weightless technology that sits inside a simplelooking patch. A family of “patch” products uses light to communicate with bio-receptors at the cellular level to help the healing body function at optimal levels. For pain, sleep, energy, stress, skin, sports performance, wound healing and more. Over 100 worldwide patents/patents pending. Over 80 clinical and research studies, many published. Using is believing!

LightStim

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Booth #3046

16552 Von Karman Avenue, Irvine, CA, 92606, US Ph: (949) 502-4088 • Fax: (949) 502-4090 Email: info@lightstim.com • Website: www.LightStim.com LightStim, the industry Leader in LED Light Therapy offers a unique approach to a clinically proven integrative treatment that will help you deliver the best possible results to your valued patients. LightStim MultiWave® Patented Technology improves overall skin function, diminishes fine lines and wrinkles, effectively reduces post procedure inflammation and bruising, and dramatically accelerates healing. Used and recommended by physicians and skin care professionals for nearly 20 years.

LIGHTWAVE Therapy

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Booth #8020

2205 W Lone Cactus Dr Ste 11, Phoenix, AZ, 85027, US Ph: (866) 999-6954 Email: info@lightwavetherapy.com • Website: www.lightwavetherapy.com With over 20 years of light therapy experience, we take great pride in designing and manufacturing the most effective LED devices available. With just under 3,000 LEDs, our Elite system is the most powerful professional light therapy system on the market. In addition, we are the only light therapy device to offer 5 FDA clearances in a single system. LIGHTWAVE is a privately-owned company based in Phoenix, AZ, where all products are designed and manufactured.

Living Younger Lifestyle Medicine

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Booth #2044

75 Palmas Court, PO Box 4736, Tubac, AZ, 85646, US Ph: (520) 229-1900 Email: gwpetersburg@msn.com • Website: www.renascenceaging.com Living Younger Lifestyle Medicine System© • Automated Patient Analysis: Biologic Age, Symptoms, Fitness, Weight & Calorie Requirements • Integrated Clinical Manuals & Protocols: BHRT, Nutrition, Exercise, Supplementation, Lifestyle • Patient charting • Patient Education • Business Startup: All forms & legal documents for a pre-paid cash retainer business • Editable practice development & marketing tools • Clinical Mentorship & Practice Consultancy • Start-up & Transition Instructions • Physician-developed; Usedsince 2007 No ongoing fees

LivOn Labs

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Booth #6067

2534 Anthem Village Dr. Ste. 100, Henderson, NV, 89052, US Ph: (702) 255-0265 ext.108 Email: Service@LivOnLabs.com • Website: www.livonlabs.com LivOn Labs is the first dietary supplement company to utilize sophisticated Liposomal Encapsulation Technology to maximize absorption of key nutrients. Our patented Lypo-Spheric™ technique encapsulates the vitamin molecules in liposomes made from Essential Phospholipids, which protect the vitamin throughout the digestive system so it is transported through your bloodstream and into your cells.

LS PRO Systems

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Booth #2047

4900 SE Division, Portland, OR, 97206, US Ph: (321) 265-9028 Email: jeff@lsprosystems.com • Website: www.lsprosystems.com LS PRO, Intelligent Light Therapy.

Since 1998 we have been working with worldwide leading experts dedicated to researching and developing the most advanced, leading edge health, sports and fitness light therapy based products, designed to specifically accelerate your bodies repair process and enhance your performance levels in sports and everyday life. If you want to improve your health, enhance your fitness, or increase your overall vitality and drive, then get energized with LS PRO Systems.

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The Complete Dispensary Solution

by Emerson Ecologics

In office

Online

Build your inventory at wholesale prices with the largest supplement catalog.

Patients order anywhere and anytime directly from your Wellevate dispensary.

• • • •

40-year reputation 300+ brands Free shipping on orders over $249 Medical Education team at your disposal through our Ask the Doc program

• • •

•

Refills stay with you Additional revenue Convenient shopping experience patients expect The Wellevate app for iOS

Coming soon!

emersonecologics.com wellevate.me

| |

800.654.4432 855.935.5382

| |

cs@emersonecologics.com support@wellevate.me

McGuff Compounding Pharmacy Services

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Booth #4072

2921 West MacArthur Boulevard, Suite 142, Santa Ana, CA, 92704, US Ph: (877) 444-1133 • Fax: (877) 444-1155 Email: pharmacyanswers@mcguff.com • Website: www.mcguffpharmacy.com McGuff Compounding Pharmacy Services provides a level of commitment and value to its sterile injection and non sterile drug products that is unsurpassed. We are independently certified and accredited by the Pharmacy Compounding Accreditation Board (PCAB). We compound all dosage forms including sterile injections and deliver to 48 US states, territories, and protectorates. Product quality and patient safety are our number one concern. Please stop by the booth to find out more!

McGuff Medical Products

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Booth #4072

3524 West Lake Center Drive, Santa Ana, CA, 92704, US Ph: (800) 854-7220 • Fax: (714) 540-5614 Email: answers@mcguff.com • Website: www.mcguffmedical.com McGuff Medical Poducts is a wholesale distributor of over 5,000 competitively priced pharmaceuticals drugs, IV related products, physician office & exam room supplies and an extensive oral nutritional line to support your patient treatments. Our experienced customer service staff are experts in finding hard-tofind products. We maintain close relations with both large and small manufacturers of quality products to assure we will meet all of your needs. Competitive prices for over 39 years!

Verified-Accredited Wholesale Distributor (VAWD)

Med Results Inc.

TM

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Booth #3063

412 W. Broadway, Ste. 303, Glendale, CA, 91204, US Ph: (818) 396-4496 Email: orders@med-results.com • Website: www.med-results.com At Med Results we are dedicated to innovative solutions in the aesthetic industry, bringing high-class products and technologies to your fingertips.

MedEsthetics Magazine

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Booth #8062

7628 Densmore Ave, Van Nuys, CA, 91406, US Ph: (818) 782-7328 Email: lfisco@creativeage.com • Website: www.medestheticsmag.com MedEsthetics is the original business magazine for medical aesthetic practitioners. The medical professionals who read MedEsthetics have buying power and view the magazine as a trusted resource to their industry.

Medical Wave LLC

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Booth #4067

30 Potomac Ct., Freehold, NJ, 07728, US Ph: (800) 595-0577 Email: info@medicalwaveus.com • Website: www.medicalwaveus.com Medical Wave is the leader in EPAT technology. We specialize in providing preventative and anti-aging medical professionals the world’s most effective and advanced EPAT technology reporting a 91 % success rate according to clinical studies. Practices across the country utilize our technology to optimize their patient’s quality of life. We are committed to helping physicians in the fields of integrative, preventative, functional and regenerative medicine improve their patient outcomes while creating new revenue streams.

Medikan International Inc

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Booth #6092

5220 4th St Suite 10, Irwindale, CA, 91706, US Ph: (888) 508-1146 • Fax: (323) 389-9142 Email: info@medikanint.com • Website: www.medikanint.com Leader of Adipose Tissue Engineering & Science

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Medithread LLC

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Booth #7066

100 S Biscayne Blvd, Miami, FL, 33131, US Ph: (786) 778-0419 Email: info@medithread.com • Website: www.medithread.com MEDiTHREAD is the market leader of PDO/PDS threads for over 8 years. We offer a wide range of smooth, barbed and mold threads that can be used in all the areas (face and body). All our threads in about six months are completely absorbed by hydrolysis. We organize hands-on classes throughout the United Sates in which we teach how to use the threads and how and/or when to combine this new technique with fillers, PRP and botulin toxin. Same-day shipping and after-sales assistance are just some examples of our dedication to quality.

Meditime Co Ltd

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Booth #2038

200 Gieopdosiro Jijeong-myeon #600 Medical Device Complex Center, Wonjusi, KR06, 26354, KR Ph: (82) 31-777-3900 Email: ybk0808@gmail.com • Website: www.meditimekorea.com AMA/ Meditime Co Ltd has been a leading global distributor of advanced medical and aesthetic solutions since 1994. We specialize in high-end laser and RF systems, along with other cutting edge equipment for skin care and medical treatments that incorporate the latest trends and technology. We are proficient in customer understanding and we promise to continuously provide our customers with the highest quality products and excellent service.

Medizap LLC

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Booth #7092

600 B Street, Ste # 300, San Diego, CA, 92101, US Ph: (415) 572-6984 Email: bcoushman@medizap.co • Website: www.medizap.co Medizap’s unrivaled all-in-one turn-key solution was designed to meet the needs of modern-day compounding.

Our programme focuses on the four pillars of E-Beam Sterilization, Packaging Solutions, Compliance, and Exclusive Partnerships. Medizap helps your pharmacy deliver world-class products using our cutting-edge technology and services. Whether you are aseptically filling, lyophilizing, or mixing powder, Medizap provides solutions to extend your products’ BUD and helps ensure your pharmacy is new USP 797 compliant.

Meridian Valley Lab

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Booth #8033

6839 Fort Dent Way, Tukwila, WA, 98188, US Ph: (206) 209-4200 • Fax: (206) 209-4211 Email: info@meridianvalleylab.com • Website: www.meridianvalleylab.com Meridian Valley Lab specializes in integrative diagnostic testing services. We are the first lab in the USA to offer comprehensive 24-hour urine hormone and metabolite testing to help doctors use Bio-Identical Hormone Replacement Therapy safely and effectively. Meridian Valley Lab is also active in food allergy testing, offering tests that cover up to 190 foods. Together with our Medical Director, Dr. Jonathan Wright, we have been taking lab testing to the next level since 1976.

Merit Pharmaceutical

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Booth #4037

2611 San Fernando Rd, Los Angeles, CA, 90065, US Ph: (323) 227-4831 • Fax: (323) 227-4833 Email: solutions@meritpharm.com • Website: www.meritpharm.com Offering IV Infusion? Getting your med/surg/pharma from us? Your colleagues are and they have higher profits. Merit supplies Anti Aging/Aesthetic/Integrative practitioners better prices on the products you use.

Stop by our booth and learn why successful clinics partner with Merit. IV Therapy Nutrition/Hydration, Weight Loss, Hormones, IV solutions, PRP products, exam/surgical supplies and more. Merit offers pharmaceuticals (2, 3, 3N, 4), and related medical products. www.meritpharm.com or (800) 69-MERIT!

Metagenics

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Booth #6007

25 Enterprise, Suite 200, Aliso Viejo, CA, 92656, US Ph: (949) 369-3375 Email: Info.customerservice@metagenics.com • Website: www.metagenics.com Metagenics was founded on a revolutionary idea: our genes do not predetermine our health potential, and through nutrition, we can impact how our genes express themselves. Embodied by our company motto—genetic potential through nutrition—this groundbreaking principle drives us to deliver high-quality, science-based nutritional supplements, medical foods, and lifestyle programs to support healthcare practitioners in their efforts to help patients achieve their health and wellness goals.

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Microbiome Labs

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Booth #3009

1332 Waukegan Rd., Glenview, IL, 60025, US Ph: (855) 729-5090 • Fax: (904) 940-2209 Email: info@gomegaspore.com • Website: www.microbiomelabs.com Microbiome Labs was originally established as Physicians Exclusive in 2013 as an organization focused on providing probiotic bacteriotherapy. Since then, Microbiome Labs has made it a goal to provide integrative solutions and clinical research data to address indications that stem from digestive and immune health issues.

MindBody Matrix

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Booth #4048

655 Minnewawa 3108, Clovis, CA, 93613, US Ph: (608) 622-7326 Email: support@mindbodymatrix.com • Website: www.mindbodymatrix.com MindBody Matrix’s purpose is to change the way we view pain while making a huge impact on the world’s dependency on opioid medication. True altruistic purpose drives each and every member and we firmly believe in the adage: “Be the change you want to see in the world.” MindBody Matrix combines the revolutionary science of Energetic Medicine with a specific blend of all-natural herbs and essential oils finally giving those in chronic pain a solution to their problem.

Mitochondrial Rescue

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Booth #6047

1395 State Rd. 7, Suite 350, Wellington, FL, 33414, US Ph: (561) 767-0721 • Fax: (561) 429-6223 Email: office-usa@mitochondrialrescue.com • Website: www.mitochondrialrescue.com Mitochondrial Rescue is an international organization dedicated to supporting Practitioners using a revolutionary HRV-based program to rescue people’s mitochondria. After completion of a readily available and affordable online training package, certified Practitioners use personalized HRV-based dosage regimens of proprietary neuropeptides and three other potentated supplements to improve patients’ power levels, autonomic dysregulation and cellular communication. This results in powerful cardiovascular, neurological and anti-aging enhancement that is measured with serial HRVs every 2 months. Results that you can measure!

MitoQ

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Booth #4047

1278 Rahway Ave, Westfield, NJ, 07090, US Ph: (908) 625-4793 Email: garabatzis@mitoq.com • Website: www.mitoq.com MitoQ® is a world-first, mitochondria-targeted CoQ10 antioxidant. MitoQ® takes a shortened version of CoQ10 and gives it a positive charge. The result of these modifications is what makes MitoQ® a scientific breakthrough: MitoQ® is instantly attractive to the negatively charged mitochondria; and MitoQ® is able to pass directly through the mitochondrial membrane. These unique properties mean that MitoQ® is absorbed directly into your mitochondria hundreds of times more effectively than standard CoQ10 supplements.

Mushroom Science

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Booth #7047

1025 Conger St. Suite 6, Eugene, OR, 97402, US Ph: (707) 227-6502 Email: shannon@mushroomscience.com • Website: www.mushroomscience.com Mushroom Science has been providing high potency mushroom extracts through its practitioner brand JHS Natural Products for the past 2 decades. Mushroom extracts have historically been prepared as a tea/ decoction, also known as a hot water extract. The scientific literature has numerous human clinical trials on the dehydrated tea form, indicating the percent of actives. Mushroom Science ingredients are certified organic, tested for purity, and guarantee levels of active compounds on every bottle.

My Practice Connect

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Booth #5066

2744 Summerdale Drive, Clearwater, FL, 33761, US Ph: (727) 330-5811 • Fax: (727) 230-1437 Email: info@mypracticeconnect.com • Website: www.mypracticeconnect.com Need medical protocols and pharmacy options? Founded by integrative physician, Brent Agin, MD MyPracticeConnect™ allows you to electronically prescribe, track, and manage your wellness meds from multiple compounding pharmacies - including Empower Pharmacy, Wells Network, APS, and more - in one centralized portal. Toggle between pharmacies and price comparison shop with the click of a button. With over 20 Nutrient IV protocols, patient resources, physician training and more -- we have what you need to streamline and build your practice!

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ANTI - AGING MEDICAL NEWS • WINTER 2019

Natural Ophthalmics, Inc.

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Booth #3036

PO Box 1510, Dillion, CO, 80453, US Ph: (970) 468-9020 • Fax: (970) 468-9042 Email: Axelrod@Natoph.com • Website: www.naturaleyedrops.com Natural Ophthalmics, Inc. distributes homeopathic, preservative-free eye drops and oral pellets. All drops are safe for use with contact lenses in place and do not sting. We have treatments for Dry Eye, Allergy, Cataracts, Glaucoma and Macular Degeneration. An Oral Vitamin Spray is also available. Our newest product addresses Traumatic Brain Injury. The products are well priced and dispensed through your office. A trial pack will be mailed upon request. Booth 3036 877-220-9710 www.NaturalEyeDrops.com

Natural Partners Fullscript

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Booth #7060

245 Cooper Street 5th Floor, Ottawa, ON, K1P 0G2, CA Ph: (866) 807-3828 Email: support@fullscript.com • Website: www.fullscript.com Natural Partners Fullscript is the best way to improve adherence and increase refills. With over 300 top brands, practitioners can simply recommend a supplement protocol through Fullscript and patients can selfcheckout online. To ensure treatment plans are followed, refill reminder and autoship features are offered to ensure patients stay on track with their treatment plans. Natural Partners offers wholesale pricing to practitioners for in-office dispensing. Sign up for free at fullscript.com or naturalpartners.com.

Natural Stacks

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Booth #2036

4800 Airport Way South, Seattle, WA, 98108, US Ph: (831) 915-8855 • Fax: (855) 678-2257 Email: wholesale@naturalstacks.com • Website: www.naturalstacks.com Natural Stacks creates Open Source supplements to Build a Better Brain, with targeted brain health products help improve mood, memory, and focus. Their best selling products include a patented nootropic, a Magnesium for the brain, a Probiotic for the brain, and 4 “BrainFood” formulas that support specific neurotransmitters like serotonin and dopamine. Natural Stacks is on a mission to build a billion better brains, and they also donate to the CureAlzheimer’s Fund!

Nelly De Vuyst

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Booth #6055

4930 Bois Franc, St. Laurent, QC, H4S1A7, CA Ph: (514) 333-8282 ext. 237 • Fax: Email: info@derme.ca • Website: www.nellydevuyst.com Nelly De Vuyst is a premium skin care brand with a longstanding reputation as one of the most effective certified organic lines in the cosmeceutical industry and is proud to be featured in many renowned magazines such as Cosmopolitan and Elle. Certified by the highest standards of certification COSMOS ORGANIC, Nelly De Vuyst’s BioTense, BioAcne and BioFemme collections are sustainable, vegan and ecofriendly. Exclusively offered through spas and medical spas.

NeuroScience

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Booth #7095

373 280th St., Osceola, WI, 54020, US Ph: (888) 342-7272 Email: customerservice@neurorelief.com • Website: www.neuroscienceinc.com Established in the Saint Croix River Valley near Osceola, Wisconsin in 2000 as a privately-owned professional grade dietary supplement company, NeuroScience offers proprietary blends of amino acids designed specifically to provide precursors for neurotransmitters. NeuroScience is recognized as a top pro-grade brand delivering premium products containing amino acids, botanicals, vitamins, and minerals exclusively to thousands of licensed healthcare providers. We specialize in brain health dietary supplements for sleep, mood and cognition.

NKMax America

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Booth #1042

10 Pasteur, Irvine, CA, 92618, US Ph: (562) 256-6974 Email: info@nkmaxamerica.com • Website: www.nkmaxhealth.com NKMax America is committed to helping people strengthen their immune system. We are the experts in harnessing the power of Natural Killer (NK) cells, the body’s first line of defense. We offer proprietary immune boosting NK cell-based products including the NK365™ supplement and the NK Vue™ immune system monitoring test.

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Nu-Scripts

™

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Booth #7102

PO Box 42009, Las Vegas, NV, 89116, US Ph: (833) 959-0015 Email: info@nu-scripts.com • Website: cinfo@nu-scripts.com Nu-Scripts™ is proud to bring the Medlab Clinical® Product line and research from Australia. Clinically trialed formulations and cosmetics using studied strains and ratios of probiotics along with micelle technology through NanoCelle™. Meet world renown researchers, Professor Luis Vitetta and David Rutolo, PhD along with Sean Hall of Medlab Clinical®, an MD with an MBA in clinical pharmaceutical management, who have aided Nu-Scripts™ to provide probiotics that are targeted to assist with specific medical conditions.

Nulife Ventures

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Booth #5027

7407 Ziegler Road, Chattanooga, TN, 37421, US Ph: (800) 398-9842 Email: support@NuLifeVentures.com • Website: www.NuLifeVentures.com NuLife Ventures is a research development, marketing and distribution company whose mission is to harness advanced technologies to redefine health and longevity. NuLife’s AVACEN 100 and AVACEN Pro are FDA cleared class two medical devices with published clinical studies for pain, fibromyalgia, autism, and microcirculation. NuLife’s Sedona Face, a PEMF device, is the first of it’s kind face-lift without the surgery.

NuMedica

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Booth #4073

9503 E.55th Place, Tulsa, OK, 74145, US Ph: (800) 869-8100 • Fax: (877) 270-2005 Email: mail@numedica.com • Website: www.numedica.com NuMedica®—Leading Clinical Nutrition Through Science & Research: Innovation at NuMedica® starts with our commitment to quality, safety and performance. As one of the leading brands of clinical nutrition in the professional market, we partner with healthcare professionals in helping their patients achieve better health. NuMedica® is an NSF® GMP Certified, FDA registered company implementing the latest Good Manufacturing Practices and quality control standards. Learn more at www.numedica.com.

Nutrafol

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Booth #6037

28 West 27th Street 10th Floor, New York, NY, 10001, US Ph: (646) 362-8976 Email: events@nutrafol.com • Website: www.nutrafol.com Nutrafol is committed to providing comprehensive nutraceutical support to target the many causes of hair loss. Our formulation combats stress, inflammation, oxidative damage, and DHT hormone sensitivity by using clinically proven, standardized ingredients. We employ a synergistic blend of botanicals including the stress adaptogen Ashwaghanda, anti-inflammatories like Curcumin, a super antioxidant Tocotrienol-rich complex and a DHT blocker Saw Palmetto. Nutrafol’s multi-targeted approach to hair loss provides a natural, safe, and effective solution to thinning hair.

Olympia Pharmaceuticals | Olympia Pharmacy

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Booth #7033

6700 Conroy Road, Suite 155, Orlando, FL, 32835, US Ph: (407) 673-2222 • Fax: (407) 673-1234 Email: info@olympiapharmacy.com • Website: www.olympiapharmacy.com Olympia Compounding Pharmacy, located in Orlando, Florida, is a state of the art, FDA 503B pharmaceutical outsourcing facility and pharmacy partner committed to setting new standards in compounding while providing access to high quality age management medications. We offer a growing line of anti-aging therapy products including IV Nutrition, Erectile Dysfunction, Age Management, Men’s Health, Women’s Health, Weight Loss, Vein Care, Sexual Health and Dermatology. As a 503B, Olympia can provide both office use and patient specific medications across the United States.

Organicell

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Booth #7065

4045 Sheridan Ave, Miami Beach, FL, 33140, US Ph: (305) 606-3430 • Fax: (786) 472-7020 Email: info@organicell.com • Website: www.organicell.com The Next Generation of Biologic Medicine Organicell is the leading, fully integrated Exosome Therapeutics Company. Our world class research, technology, manufacturing and clinical development team is focused on creating new biologic medicine. We believe that our ground-breaking research in the field of nanotechnology, specifically exosomes and other micro vesicles, is the next frontier of stem cell-based exosome therapeutics. Organicell is committed to creating life changing and lifesaving therapies for patients.

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Ortho Molecular Products

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Booth #4027

28160 W. Northwest Hwy, Ste. 100, Barrington, IL, 60010, US Ph: (815) 206-6586 Email: contactus@ompimail.com • Website: www.orthomolecularproducts.com For over 30 years, Ortho Molecular Products has partnered exclusively with health care providers to deliver nutritional solutions of the highest efficacy. The most trusted voices in health care put their trust in our products to help patients get better, faster. Our commitment to science, careful raw ingredient selection, and strict quality standards goes into every supplement we formulate. To learn more, visit www. orthomolecularproducts.com or call 1-800-332-2351.

OxyHealth

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Booth #3021

10719 Norwalk Blvd., Santa Fe Springs, CA, 90670, US Ph: (562) 906-8888 Email: information@oxyhealth.com • Website: www.oxyhealth.com OxyHealth is the world’s leading provider of hyperbaric chambers. Presently, OxyHealth is the pioneer of the industry with over 15,000 chambers in use, more than all other providers combined. OxyHealth continues to remain at the forefront of superior performance, quality and cutting-edge design concepts that far exceed industry safety standards

PedsPal GPO

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Booth #5072

801 7th Ave, Ft. Worth, TX, 76104, US Ph: (877) 923-2233 Email: debbie.standridge@cookchildrens.org • Website: www.pedspal.org We are the purchasing program for Top Doctors and have several new programs to give our members of all specialties more in-office testing at new lower costs to help boost your revenue and provide expanded services for your patients. Please check out www.pedspal.org for details.

Pellecome LLC

•

® Discounts for ALL physicians

Booth #8074

111 Canfield Ave,Ste. A-7, Randolph, NJ, 07869, US Ph: (888) 773-9969 Email: info@pellecome.com • Website: www.pellecome.com Pellecome is a medical company which introduced the Re3 Advanced Pellet Delivery System for Men and Women, a medical device kit that enables clinicians of any specialty to insert pellets easily and safely, every time. The kit includes an insertion tool with needle guide, precision scalpel and convenient needle filler.

The Pellecome insertion device places pellets in a perfect line every time, providing consistent hormone absorption and minimizing patient discomfort and risk of pellet extrusion.

Pharma Nord, Inc.

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Booth #1038

4 Argonne Ave., Hamilton, NJ, 08620, US Ph: (609) 585-0101 Email: mhovgaard@pharmanord.com • Website: www.pharmanord.com Pharma Nord, Inc. is a manufacturer with focus on medicine for diseases based on a Coenzyme Q10 API and an active scientific collaborator for new low-risk treatments/adjunctive therapies (cardiovascular, etc.). Myoqinon is a registered medicine in several EU countries and is sold in the US as a Pharmaceuticalgrade OTC dietary supplement under the name Bio-Quinone Active CoQ10 GOLD. The product has been investigated in 78 human clinical trials of which 26 are Gold Standard.

Physician Compounding Alliance

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Booth #8038

2690 White Rock Lane, Colorado Springs, CO, 80904, US Ph: (719) 646-6085 Email: dbroer.pca@gmail.com • Website: www.physiciancompoundingalliance.com Physician Compounding Alliance exists to solve the critical issues facing our clients, both large and small. Our unique approach in dispensing BHRT not only differentiates us, but is also what makes us successful. We provide a broad range of services and solutions to help medical practices facilitate change, achieve their vision, optimize performance and productivity within their practice. Let us know how we can help your practice!

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Dental

TM

BROAD-SPECTRUM TOOTHPASTE AND LIPOSOMAL ORAL CARE SOLUTION WITH BIOCIDIN®

Remove Pathogenic Biofilms and Restore the Oral Microbiome with Broad-Spectrum Botanicals Simple, Clinically-Effective, Oral Care Solutions for the Entire Family Dentalcidin™ Toothpaste 20% Biocidin® broad-spectrum combination* Daily use toothpaste, perfect for both children and adults Professional grade Zeodent® hydrated silica for gentle and effective cleaning Tastes great and free from sugar, gluten, fluoride, artificial flavorings, and colors

Dentalcidin™LS Liposomal Oral Care Solution Liposomal Biocidin® plus clove and myrrh fight biofilms, plaque, and mouth odors* Co Q10 and quercetin support oral tissues and help reduce inflammation and speed repair* Dentists recommend for increased support for periodontal challenges and after any dental work*

Research shows results in as little as 4-8 weeks of use* *These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure or prevent any disease.

BIO-BOTANICAL RESEARCH INC.

Clinically Effective, Evidence Based

Biocidin.com

TotalSkin Solution

TM

Lutronic Genius™ + LaseMD® Booth #4100 High Intensity Precision RF

Non-ablative Fractional 1927nm Thulium Laser BEFORE

AFTER 3 SESSIONS

Courtesy of S. Weiner, MD

Distinguish your practice by offering two best in class devices and a unique anti-aging solution.

HAIR & SCALP REVITALIZATION with the perfect complement:

+

BEFORE

Courtesy of W. Loverme, MD

AFTER 2 MONTHS

®

KeraFactor Peptide Complex (KFP™) is a hair and scalp treatment serum containing a unique and proprietary formulation.

This one-of-a-kind topical serum contains five synthetic growth factors and two skin proteins, essential for scalp and hair health. Each highly concentrated peptide is individually wrapped in a nano-liposome carrier for enhanced absorption by the skin.

aesthetic.lutronic.com ©2019. LUTRONIC Group of Companies. All rights reserved. LUTRONIC, its logo, Lutronic Intelligent Care, TotalSkin Solution, Lutronic Genius, LaseMD, KeraFactor, and KFP are trademarks or registered trademarks of the LUTRONIC Group of Companies. This product or the use of this product is covered by one or more US and foreign patents or patent applications pending.

PRD_TRD_00001_TSSKF_v1 USA

Physician Lab Inc.

•

Booth #2035

4850 T-Rex Ave., Suite 150, Boca Raton, FL, 33431, US Ph: (877) 316-8686 Email: info@physicianslab.com • Website: www.physicianslab.com Physicians Lab is one of the nation’s leading urinary hormone testing laboratory, delivering State-ofthe-art Science with Superior Solutions. We beat the competition in price and turnaround-times, while providing accurate, reliable LC/MS/MS results. With our tools, education and training, we give you everything needed to offer patients convenient, affordable, and error-free testing.

PhysioAge

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Booth #9061

30 Central Park South, New York, NY, 10019, US Ph: (877) 722-7093 Email: jerry@physioage.com • Website: www.physioage.com PhysioAge is an integrated clinical system that combines everything you need to deliver next-generation physical exams. Our software can tell you how well your patients are aging using sophisticated Biomarkers of Aging that are highly correlated with age: arterial stiffness, lung function, skin elasticity, cognitive function, immune function and telomere lengths. Tracking physiological age over time can help you measure the effects of your treatment programs. Contact us for a software demo!

Plattr

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Booth #7011

1889 E. Maule Ave, Ste. G, Las Vegas, NV, 89119, US Ph: (512) 960-2303 • Fax: (949) 378-4983 Email: served@plattr.com • Website: www.plattr.com With over 10 years of marketing experience, leave it to the digital marketing pros at Plattr to get your practice discovered. We can find the RIGHT patients, build patient loyalty, and keep a constant stream of patients always looking for your expertise when it comes to their health needs. Let us help you grow your practice while you continue to improve the lives of many.

Pneuma Nitric Oxide LLC

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Booth #3062

2407 S. Congress Ave., Ste. E-134, Austin, TX, 78704, US Ph: (877) 4PN-EUMA Email: support@pneumanitricoxide.com • Website: www.pneumanitricoxide.com Pneuma Nitric Oxide, LLC was established to commercialize scientifically proven nitric oxide based technologies for use in skin care and cosmetics.Our mission is to revolutionize the beauty industry through the development of products that improve blood flow and circulation to the skin based on the production of nitric oxide. There are no such products currently on the market. Our technology connects wellness to beauty.

Podcasting and Videos Made Easy

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Booth #2088

16118 Caldera Ln, Naples, FL, 34110, US Ph: (248) 705-7893 Email: shawnsmith@themobilepro.net • Website: www.podcastingandvideosmadeeasy.com Podcasting and Videos Made Easy trains you and your staff to create pro-quality marketing content even if you’re a non-techie designed to 10X the sales of your services. Through our in-person workshops, follow-up support, and access to our network of trusted partners, we equip doctors to exponentially increase sales by marketing ALL services to their existing patient base and new patients alike. Bring your practice into the 21st century. Harness the power of online marketing.

Power2Practice

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Booth #7027

2907 Butterfield Rd, St 100, Oak Brook, IL, 60523, US Ph: (312) 546-3220 Email: info@power2practice.com • Website: www.power2practice.com Power2Practice (P2P) is a driving force in integrative health, helping foster healthier practices and healthier lives. Built on a specialized EMR and practice management platform, P2P helps practices improve their business, simplify care, and increase patient satisfaction.

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Predictive Biotech, Inc

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Booth #7026

2735 East Parleys Way, Suite 205, Salt Lake City, UT, 84109, US Ph: (888) 407-9761 Email: inquiries@predictivebiotech.com • Website: www.predictivebiotech.com Predictive Biotech, Inc., a Salt Lake City, UT life sciences Company formed in 2015, is a leader in human cell and tissue products for use in regenerative medicine. A growing national network of clinics, health systems, researchers and physicians leverage Predictive’s four main placental-derived and Wharton’s Jelly umbilical cord-derived products. Predictive Biotech products are regulated by the FDA under 21 CFR part 1271 section 361 as minimally manipulated allografts intended for homologous use.

Premier Research Labs

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Booth #2060

3500-B Wadley Pl., Austin, TX, 78728, US Ph: (800) 325-7734 ext. 2529 • Fax: (512) 341-3931 Email: vramirez@prlabs.com • Website: www.prlabs.com Premier Research Labs (PRL) provides 100% non-toxic and effective nutritional products for practitioners within an impressive cGMP and USP certified manufacturing facility. Extensively scientifically laboratory tested in-house, formulas are free of undesirable chemical tagalongs, animal glandulars, and excipients.

Experience a new dimension of nutritional excellence with Premier Research Labs!

Prestige Products Direct/TriadAer

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Booth #9043

12440 SW 117 CT, Miami, FL, 33186, US Ph: (305)234-8081 Email: directprestige@gmail.com Triad Aer, an air purification system that combines three innovative technologies to reduce particles and microbes to create a healthier environment with minimal energy consumption.

Professional Health Products

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Booth #8096

PO Box 97227, Pittsburgh, PA, 15229, US Ph: (800) 245-7313 Email: support@phpltd.com • Website: www.phpltd.com For more than 40 years, Professional Health Products has provided innovative nutrition with superior ingredients that clinicians trust! Superior nutritional products have the power to improve your health and wellness.That’s why we believe Professional Health Products should be administered and monitored by licensed or certified health care practitioners.

Protocol For Life Balance

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Booth #8043

244 Knollwood Drive, Bloomingdale, IL, 60108, US Ph: (253) 549-2891 • Fax: (855) 833-9012 Email: sales@protocolforlife.com • Website: www.protocolforlife.com Protocol For Life Balance is a well-researched, potent, and efficacious brand of high-quality dietary supplements and natural products sold exclusively through licensed healthcare practitioners. Protocol For Life Balance offers many unique formulas and products, that come with a money -back guarantee if any patient is less than 100% satisfied. Our mission is simply to provide quality products that lead to healthy patients and satisfied physicians.

PULS Cardiac Test

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Booth #6033

13885 Alton Parkway, Suite B, Irvine, CA, 92618, US Ph: (866) 299-8998 Email: info@pulstest.com • Website: www.pulstest.com The PULS Cardiac Test measures key clinical risk factors as well as 9 unique protein biomarkers. These markers are associated with the biological pathways underlying cardiac lesion formation, progression and rupture. The refined methodology of PULS cardiac risk assessment provides an improved calculation of a patient’s near-term (5 year) risk for a heart attack, and allows for the reclassification of nearly half of those patients considered in the clinical ‘grey zone’.

ANTI - AGING MEDICAL NEWS • WINTER 2019

C A R D I AC T E ST

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Pulse Centers

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Booth #8078

969Mirador Dr. N., Aurora, IL, 60542, US Ph: (847) 323-5635 Email: jlehotay@pulsecenters.com • Website: www.pulsecenters.com Pulse Centers is the world leader in high-powered Pulsed Electromagnetic Field ( PEMF ) systems. Our products are designed to deliver PEMF to the whole body and targeted areas simultaneously. Our mission is to continue to redefine the boundaries of PEMF applications and offer unparalleled training. Learn why “cellular exercise” is becoming an essential advancement in pre and post regenerative rehabilitation protocols. Meet Greg Johnson, Jason Massucci, Joe LeHotay, and Tom Butler. Try Pulse today!

Purium

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Booth #7061

14962 East Fantz Avenue, Parlier, CA, 93648, US Ph: (559) 999-0216 Email: myleffel@gmail.com • Website: www.wellnessmadebetter.com “Purium” is high concentrations of pure food with no additives of any kind. It’s organic and non GMO. Safe wholesome foods give you high energy and health; so that the body heals and builds itself. Purium doesn’t believe in diets or starving the body. The goal is to feed the body the nutrients needed daily with high nutrition low calorie food. Checkout our 1500 mg CBD spray.

Qest, LLC

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Booth #8035

5548 W. 11350 N., Highland, UT, 84003, US Ph: (801) 400-4985 Email: brady@qest4.com • Website: www.qest4.com Qest4 is the world leader in bioenergetic and bio-resonance testing. The Qest4 system communicates with the innate intelligence (or energy, chi, spirit, etc.) through informational frequency patterns sent out of the system, and receives response from the body through electrodes. This transference of information through energetic language is how everything becomes interconnected. With Qest4, you are able to find the bigger picture, so you can see causes to issues instead of endlessly chasing symptoms.

Qualgen

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Booth #1064

301 Enterprise Dr., Edmond, OK, 73013, US Ph: (918) 601-6077 • Fax: (405) 286-3755 Email: sales@qualgen.us • Website: www.qualgen.us Qualgen, a U.S. based company located in Edmond, Oklahoma, is a global leader in compounding pharmaceutical production. Founded in 2012, Qualgen offers the purest bio-identical hormone replacement pellets on the market, as well as, numerous scientifically advanced compounds in multiple markets around the world.

Quest Diagnostics - Cleveland HeartLabs

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Booth #5090

6701 Carnegie Ave., Ste.500, Cleveland, OH, 44103, US Ph: (216) 213-3656 Email: komalley@clevelandheartlab.com • Website: www.clevelandheartlab.com The Quest Diagnostics-Cleveland HeartLab Cardiometabolic Center of Excellence is committed to advancing the prevention of the most costly and debilitating cardiovascular events. Our broadly available comprehensive menu of novel biomarkers spanning the cardiometabolic continuum provides deeper insights into hidden risk that go well beyond traditional testing. By combining this enhanced diagnostic capability with solutions to help engage patients in their care, we empower people to take action to reduce cardiometabolic risk, while improving long-term health outcomes.

Quicksilver Scientific

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Booth #5021

1376 Miners Dr. Ste. 103, Lafayette, CO, 80026, US Ph: (303) 531-0861 ext. 172 Email: support@quicksilverscientific.com • Website: www.quicksilverscientific.com Quicksilver Scientific® is a leading manufacturer of advanced nutritional systems with a focus on detoxification. We specialize in superior liposomal delivery systems and heavy metal testing to support optimal health. We are passionate about health and well-being and are committed to improving the lives of everyone we touch.

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Rebel Herbs

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Booth #2085

885 South College Mall Road, PMB 161, Bloomington, IN, 47401, US Ph: (812) 762-4400 Email: order@rebelherbs.com • Website: www.rebelherbs.com We are a line of herbal products made from plants that grow on our own certified organic farms in India or the organic coop we founded. We offer unique delivery systems including, powerful dual extracted powders, encapsulated formulas, massage oils, and our unique inhalable herbal blends. We have updated the ancient Dhum Pan therapy of Ayurveda through our vapors which contain NO nicotine, cannabis, chemicals, solvents, synthetics, propylene glycol, vitamin E acetate or vegetable Glycerin.

ReeLabs Private Limited

•

Booth #7104

K.K. Chambers, Sir P.T. Road, 1st floor, Mumbai, , 400001, IN Ph: (91)9820180076 Email: aps@reelabs.com • Website: www.reelabs.com ReeLabs has devoted the past decade to establish itself as a recognised authority in the field of stem cell collection and utilisation. ReeLabs has filed numerous international patents and launched clinical trials showcasing their applications related to their unique proprietary stem cell therapy protocols and advanced anti-ageing products. In its continued commitment to stem cell research, ReeLabs has recently set up a Asia’s largest, state of the art stem cell laboratory in Mumbai.

Refine USA LLC

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Booth #7085

340 3rd Ave S, Ste C, Jacksonville Beach, FL, 32250, US Ph: (866) 590-5533 Email: sales@refineusa.com • Website: www.refineusa.com Refine USA has been a market leader in the manufacturing and distribution of premier aesthetic technologies for over 15 years. We pride ourselves in designing and developing medical devices that meet the clinical and financial needs of aesthetic health care providers.

Regenative Labs

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Booth #9026

1700 West Main St., Pensacola, FL, 32502, US Ph: (601) 954-4517 Email: tyler@regenativelabs.com • Website: www.regenativelabs.com Regenative Labs manufactures human tissue products for homologous use . Their injectable Celltext™ product has proven more effective than invasive conventional treatments. Celltext™ utilizes growth factors found in umbilical cord tissue to add structural support to injured joints and surrounding tissue. The tissue, ethically obtained from full-term C-Sections with patient consent, is safety tested according to FDA and AATB criteria.

Regenerate Joy

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Booth #3073

233 Old Gage Hill Rd., Pelham, NH, 03076, US Ph: (508) 864-7685 Email: info@regeneratejoy.com • Website: www.regeneratejoy.com Best in class products to help private practices add revenue and give more healing options to patients

Regul8 Pty Ltd

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Booth #3081

9 Waltham Street, Artarmon, NSW, 2064, AU Ph: (61) 28-424-6688 Email: info@regul8.com.au • Website: www.regul8.com.au Designed to support the cleansing, restoration and maintenance of digestive health and originating from herbal medicine practices, the Regul8™ range includes all-natural, plant based, gluten free formulations to promote inner health and an outer glow.

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BOOTH #2015 Neil Riordan, P.A., PhD. Saturday, 1:00-2:00PM

Anti-Inflammatory and Regenerative Properties of Afterbirth

Jonathan Hernandez, PhD. - Friday, 12:00-12:30PM Signature Biologics in the Product Theater

www.neilriordan.com

Rejuvenation Science

•

Booth #4039

5334 Torrance Blvd., 2nd Floor, Torrance, CA, 90503, US Ph: (310) 798-2830 Email: Roxanne@rejuvenation-science.com • Website: www.rejuvenation-science.com Sophisticated supplements for integrative, regenerative, and functional medicine practices begin with toprated Maximum Vitality multivitamin. Support brain health with nootropics and phospholipid bound omega-3s, endocannabinoid management for pain, inflammation, anxiety and sleep with full-spectrum nano-CBD tincture, mitochondrial and organ energy with mitochondrial optimizer protocol including cellular optimizer, mitochondrial biogenesis and ubiquinol, third generation joint support with HA and CMO. Please chat with us to understand our quality, knowledge, and integrity.

Relax Saunas of Momentum

•

Booth #8084

3509 N. High St., Columbus, OH, 43214, US Ph: (626) 200-8454 Email: moment98@aol.com • Website: www.relaxsaunas.com The Relax Sauna company spent 10 years discovering how to Filter out Near and Mid-infrared rays. Only Far infrared Light is absorbed by the Human body. Because of our advanced technology, the Relax Sauna increases core temperature faster and achieves greater results compared to other saunas. The Relax Sauna is a proven far infrared energy technology leader, with an 18-year record of Effectiveness at overcoming ailments, while providing youth, beauty and vitality to its users.

Researched Nutritionals

•

Booth #2039

PO Box 224, Los Olivos, CA, 93441, US Ph: (805) 693-1802 Email: customerservice@researchednutritionals.com • Website: www.researchednutritionals.com Researched Nutritionals is differentiated by its ongoing, peer-reviewed published clinical research to prove product efficacy that your patients feel. Research Highlights: ATP 360®- 52% fatigue reduction &12% diastolic blood pressure reduction; Tri-Fortify™ liposomal glutathione- 28% increase in intracellular glutathione & 400% increase in NK cell function; Transfer Factor Multi-Immune™- 620% increase in NK Cell function &powerful immune modulation; CytoQuel®- 65% pain reduction, 44% sleep improvement & highly significant correlation with MMP-9 improvement & pain reduction.

Resync LLC

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Booth #8046

4580 PGA Blvd Suite 2015, Palm Beach Gardens, FL, 33418, US Ph: (561) 469-7655 Email: info@resyncproducts.com • Website: www.resyncproducts.com Resync Recovery Blend is based on natural nitric oxide proprietary blend mixed with high quality antioxidants to support energy, blood flow, and healthy inflammatory response due to exercise.† Resync Collagen Blend is based on 15 grams of hydrolyzed collagen mixed with our proprietary nitric oxide blend, vitamin C, hyaluronic acid, and calcium fructoborate to support skin, nails, joints and connective tissue health. †

Rhein Consulting Laboratories

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Booth #5044

4475 SW Scholls Ferry Road. Suite 101, Portland, OR, 97225, US Ph: (503) 292-1988 • Fax: (503) 292-2012 Email: ingridnordt@rheinlabs.com • Website: www.rheinlabs.com Rhein Consulting Laboratories, specializing in hormone profiling, is a research driven facility, which provides patients and their physicians with state-of-the-art, cost-effective means of assessing sex and adrenal hormone levels. In contrast to salivary and spot testing, hormones assayed in urine are clinically relevant, accurate, and reproducible as well as widely accepted in medical and academic scientific circles.

Riordan Technologies

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Booth #2015

11496 Luna Rd. Suite 800, Dallas, TX, 75234, US Ph: (972) 807-5916 Email: info@neilriordan.com • Website: www.neilriordan.com Riordan Technologies strives to improve the human condition through innovation in scientific research, regenerative medicine, and stem cell therapy. Riordan Technologies is comprised of a network of companies founded by Neil Riordan, PA, PhD: Dallas-based Aidan Products, Signature Biologics, and Riordan Medical Institute; Panama-based Stem Cell Institute and Medistem.

ANTI - AGING MEDICAL NEWS • WINTER 2019

181

SBA Loan Group

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Booth #2063

84 W. Park Place, Stamford, CT, 06901, US Ph: (347) 533-6261 Email: john@sbaloangroup.com • Website: www.sbaloangroup.com SBA Loan Group is a private company that helps Small Business Owners obtain financing for Working Capital, Business Acquisitions & Real Estate, through the U.S. government run SBA loan program.

Sciton Inc

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Booth #4032

925 Commerial Street, Palo Alto, CA, 94303, US Ph: (650) 493-9155 Email: info@sciton.com • Website: www.sciton.com Sciton is committed to providing best-in-class laser and light solutions for medical professionals who want superior durability, performance and value. Sciton offers superior medical devices for laser-assisted lipolysis, fractional and full-coverage skin resurfacing, hair removal, phototherapy, wrinkle reduction, treatment of vascular and pigmented lesions, scar reduction, and acne. For more information, and a complete listing of Sciton systems, visit www.Sciton.com.

Seca

•

Booth #7039

13601 Benson Ave., Chino, CA, 91710, US Ph: (800) 542-7322 Email: info.us@seca.com • Website: www.mbca.seca.com Because every patient is unique, therapy must be individualized. Gain valuable insights on how hormone replacement therapy is affecting skeletal muscle mass in andropause and menopause patients. Detect muscle mass deficiencies, excessive visceral fat and monitor fluid distribution with the seca mBCA—the only body composition analyzer designed for medical use and validated to the gold standard. Transform how you optimize hormones with quantifiable results.

Selphyl

•

Booth #1048

940 Town Center Dr, Ste F20, Langhorne, PA, 19047, US Ph: (267) 391-9685 Email: kristin@factormedical.com • Website: www.selphyl.com The Selphyl® System is designed for the safe and rapid preparation of PRFfrom a small sample of blood at the patient point of care. Many PRP systems require operator skill, have varying results and have extensive contamination with red blood cells and white blood cells. PRP is converted to PRFM through a controlled process, creating a scaffold that serves to protect and preserve platelets. Think of Selphyl® PRFM as the next generation PRP.

Softwave TRT

•

Booth #7096

251 Heritage Walk, Woodstock, GA, 30188, US Ph: (888) 862-6162 Email: info@trtllc.com • Website: www.trtllc.com SoftWave TRT is a global biotechnology company specializing in unfocused shockwave devices. We discovered and patented stem cell activation / exosome release effects of low energy, unfocused acoustic pulses with a robust publication portfolio including more that 75 clinical studies. The recently FDA cleared, German engineered UroGold 100 features several ANTI-AGING applications including Men’s and Women’s Sexual Health, Cosmetics, Pain Management, Diabetic Foot Ulcers and Nerve Regeneration revolutionizing nonsurgical treatment options.

Sovereign Laboratories

•

Booth #3078

2020 Contractors Road Suite 6, Sedona, AZ, 86336, US Ph: (928) 202-4031 Email: info@prosovlabs.com • Website: www.sovereignlaboratories.com Sovereign Laboratories is dedicated to developing natural products that provide the most efficacious solutions for optimal health, vitality, and aesthetics. Sovereign Laboratories’ signature product Colostrum-LD® is clinically proven to heal the G.I. lining; prevent infection and inflammation of the bowel; and increase bowel surface area for better nutritional absorption. Colostrum-LD® is considered the premier foundational supplement for optimal gut and immune health and it was designed for successful aging no matter where one is on the spectrum of life.

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Specialty MED Training

•

Booth #2033

19646 Dinner Key Drive, Boca Raton, FL, 33498, US Ph: (561) 703-5851 Email: info@specialtymedtraining.com • Website: www.specialtymedtraining.com Specialty MED is a national training, research and marketing company; dedicated to helping physicians bring the latest regenerative therapies and treatment options to their patients. Specialty MED is actively building a national network of leading providers committed to the ethical and responsible advancement of the use of regenerative therapies in clinical practice. Our mission is to provide and collect the most current scientific and clinical data to drive protocol and best practice decisions while leading the path towards evidence-based medicine.

SpectraCell Laboratories

•

Booth #8015

10401 Town Park Drive, Houston, TX, 77072, US Ph: (800) 227-5227 • Fax: (713) 758-0160 Email: support@spectracell.com • Website: www.spectracell.com SpectraCell Laboratories, Inc. is a leading clinical laboratory specializing in personalized disease prevention and management solutions. Our pioneering nutritional and cardiometabolic testing, driven by state-of-the-art technology, assesses a spectrum of risk factors and biomarkers for optimum wellness. Through our dedication to research and development, SpectraCell also provides innovative solutions for hormone health and genetics.

The SpectraCell Solution is integral to your goal of optimizing patient outcomes by facilitating the prevention and early detection/ diagnosis of deficiency and disease, while helping guide effective treatment options.

Standard Process Inc.

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Booth #6079

1200 W. Royal Lee Drive, Palmyra, WI, 53156, US Ph: (262) 495-6401 Email: info@standardprocess.com • Website: www.standardprocess.com Since 1929, Standard Process® has been a visionary leader in whole food nutrient solutions. The company creates quality nutritional supplements based on the whole food philosophy of its founder, Dr. Royal Lee. Palmyra, Wisconsin-based Standard Process also offers Veterinary Formulas™ and is the exclusive U.S. Distributor of MediHerb® herbal supplements.

Stellar Biomolecular Research

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Booth #4080

Klostertrabe 205, Edenkoben, RP, 67480, DE Ph: (608) 844-8989 Email: info@sbi-europe.com • Website: www.sbi-europe.com Stellar Biomolecular Research (SBR) is a German scientific research company specializing in a diverse range of biomolecular products that are distributed to and used by an extensive network of medical practitioners and consumers in over 77 countries. SBR also offer consulting expertise that includes the commercialization strategies and management of integrated biological laboratory and biological medicine centers, as well as clinical and technical trainings on integrative, regenerative and biological medicine.

Synca Wellness

•

Booth #1062

1600 Landmark Drive, Cottage Grove, WI, 53527, US Ph: (608) 640-8633 Email: tim.sharpe@jhtna.com • Website: www.synca-wellness.us Premiere manufacturer of Japanese design and programmed massage chairs. As a manufacturer, our quality control and service network cannot be matched by anyone. Visit our booth to see the difference in massage quality with our 4D Japanese style massage chairs.

T.A. Sciences

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Booth #5007

420 Lexington Avenue, New York, NY, 10170, US Ph: (212) 588-8805 • Fax: (212) 588-0058 Email: michael@tasciences.com • Website: www.tasciences.com T.A. Sciences® is dedicated exclusively to creating research-based, clinically tested wellness products that help address telomere shortening through the science of Telomerase Activation. Telomeres are the caps at the end of each strand of DNA that protect our chromosomes, like the plastic tips at the end of shoelaces.

Telomeres get shorter as we get older, which may leave chromoses unprotected. T.A. Sciences® products focus on lengthening telomeres. © T.A. Sciences | TA-65 Supplement | Telomerase Activation Source: https://www.tasciences.com/ © Protected by WebToMed

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Tailor Made Compounding

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Booth #7011

200 Moore Drive, Nicholasville, KY, 40356, US Ph: (859) 887-0013 Email: support@tailormadehealth.com • Website: www.tailormadecompounding.com We have established ourselves as one of the top compounding pharmacies in the nation through our compounding expertise, knowledge, and experience. We have been able to establish a reputation for working closely with our physicians and being the problem solvers for hard to source and hard to compound pharmaceuticals. The vision of Tailor Made Compounding is to positively disrupt medicine, using innovative technologies through education and partnership. Our pharmacy strives to deliver education by cultivating close working relationships with physicians and investing in research and development.

Tanita Corporation

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Booth #3075

2625 S. Clearbrook Dr., Arlington Hts., IL, 60005, US Ph: (847) 640-9241 Email: 4health@tanita.com • Website: www.tanita.com Tanita is a world leader in weight and body composition measurement. For 75 years the quality and accuracy of our products have made Tanita THE STANDARD by which other scales and body compositions monitors are measured. Tanita offers a full line of innovating, versatile, and easy to use scales and monitors used by people around the world.

Terra Biological LLC

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Booth #4070

3830 Valley Centre Drive, Suite 705 PMB 561, San Diego, CA, 92130, US Ph: (858) 947-5722 Email: acash@terrabiological.com • Website: www.benagene.com Terra Biological develops therapeutic compounds that target the metabolic environment for support of anti-aging, improved energy and better cellular functioning. Its flagship product, “benaGene” (Oxaloacetate) delivers many benefits: • Anti-Aging. A potent calorie restriction mimetic • Glucose System Support.AMPK activation for stable glucose support • Fights Fatigue/Increases Endurance.Used by Olympic and National Athletes • Supports Mitochondria.Stimulates mitochondrial biogenesis • Reduces Inflammation Pathways.

Reduction in the mTOR and NF-kB inflammation pathways

TheraPellET

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Booth #1034

960 Caughlin Crossing N. , Ste.100, Reno, NV, 89519, US Ph: (775) 348-9798 • Fax: (775) 348-5809 Email: mv@therapellet • Website: www.therapellet.com Bioidentical Hormone Replacement Therapy for men and women utilizing a patient specific dosing with 6 month treatment intervals.

Thermi

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Booth #7086

3131 W. Royal Ln., Suite 100, Irving, TX, 75063, US Ph: (214) 612-5849 Email: info@thermi.com • Website: www.thermi.com Thermi®, a Celling Biosciences company, is a global leader in advanced temperature-controlled radiofrequency technology. Thermi systems offer versatile modalities (ThermiTight®, ThermiSmooth® Face, and ThermiVa®) and safely delivers rapid results through controlled heating using RF to impact positive tissue change and naturally stimulate collagen. Clinicians use Thermi technology to help address common signs of aging.

THOR Photomedicine

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Booth #6043

5021 Michael’s Meadow Drive, Hampstead, MD, 21074, US Ph: (877) 355-3151 Email: mark.granic@thorlaser.com • Website: www.thorlaser.com THOR Photomedicine specializes in photobiomodulation (PBM) technology and as an industry leader have presented to the US Congress, United Nations, and NICE (UK) on the use of PBM for pain management.

While drugs cover up pain, our devices actually heal people and treat the source of the pain. THOR products have become indispensable tools at world class institutions including Harvard, NYU, The Veterans Administration, NHS (UK) and others, revolutionizing pain management and injury recovery programs.

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novothor.com

Irrationally Committed, meet Obsessively Engineered.

The science of photobiomodulation isn’t new.

After thirty years of dedicated study, our extensive knowledge of its application and dose-response relationship has culminated in the NovoTHOR WholeBody Light Pod, a breakthrough device delivering photobiomodulation therapy (PBMT) from head-to-toe.

NovoTHOR embodies our commitment to healing without drugs or surgery, and our mission to design the most effective devices possible. Engineered to exacting standards for dose and wavelength, NovoTHOR produces patient outcomes unmatched by any other device of its kind.

NovoTHOR sessions can be used to achieve the following: ♦ Restoration of motion to joints ♦ Redevelop muscles ♦ Adjunct to obesity as part of a diet and exercise program ♦ Temporary relief of minor muscle and joint aches, pain and stiffness ♦ Relaxation of muscles and relief from muscle spasms ♦ Temporary relief of minor muscle and joint aches, pain and stiffness ♦ Temporary relief of minor pain and stiffness associated with arthritis ♦ To temporarily increase blood circulation

Visit Booth #6043 to see the NovoTHOR in action Mark Granic I mark.granic@thorlaser.com I Toll-free 1 877 355 3151

Tigovit

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Booth #7062

5238 Canyonland Way, Venice, FL, 34293, US Ph: (941) 313-0358 Email: info@tigovit.us • Website: www.tigovitus.com Tigovit introduces innovative EGCG based nutraceuticals to the North American Market. Tigovit and tigosol are developed and produced in Germany by Tahovital GmbH and both products are represented in the US through Tigovit US. The ingredients in those supplements are independent laboratory tested to insure the highest quality standards.

Trocar Supplies

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Booth #8034

515 Monmouth St. Suite 103, Newport, KY, 41071, US Ph: (937) 478-0469 • Fax: (250) 650-5890 Email: trocarsupplies@gmail.com • Website: www.trocarsupplies.com Trocar Supplies has been providing a range of products for the pellet procedure for many years.

Our range has expanded as we listen to customers request to include resin trocars, resin/stainless steel trocars and all metal trocars. We can custom make any kit your requirement including the compartmentalized tray. We also offer the reusable instruments, including medicine cups, forceps and trays for the autoclave.

Tru Niagen - ChromaDex

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Booth #6094

10005 Murilands Blvd., Suite G, Irvine, CA, 92618, US Ph: (888) 642-4361 Email: Practitioner@TruNiagen.com • Website: www.practitioner.truniagen.com TRU NIAGEN® is a unique cell-charging form of vitamin B3 clinically-proven to safely and effectively increase levels of the critical co-factor nicotinamide adenine dinucleotide (NAD+). NAD+ regulates the response of important genetic pathways to stressors, including aging. Increased NAD+ levels encourage healthy mitochondrial function, stimulate cellular energy production, and support healthy sirtuin activity. Learn more at Practitioner.TruNiagen.com

Uforia Sciences, LLC

•

Booth #8070

Jerome Dixon, DO, 150 West Beartrack Road, Campbellsville, KY, 42718, US Ph: (270) 465-0139 Email: dixado@gmail.com • Website: www.doctord.uforiascience.com Offer genetically-guided, individually compounded nutritional supplements to your patients.

Seamlessly test your patients’ genes, review each customized formula (from almost 400 million possible combinations), and cost-effectively deliver that personalized product direct to your patient under your own brand. Further customize each formula where appropriate for compatibility with care plans, prescription medication, food allergies and sensitivities, etc.

Ulta Lab Tests

Ulta Lab Tests

®

Know Your Health, One Lab Test at a Time!

•

Booth #4060

8436 E Shea Blvd, Suite 102, Scottsdale, AZ, 85260, US Ph: (480) 681-4081 Email: contactus@ultalabtests.com • Website: www.ultalabtests.com Ulta Lab Tests offers Healthcare Professionals discounts on laboratory services and a free practice management solution. We also support unlicensed Healthcare Professionals with Medical Directors to support their clients. Key Benefits Include: Save up to 90% | Results in 12-48 hrs. | 2,000 Quest labs | 2,100 Patient Service Centers | Online Appointments | Web & Mobile| Quick Order | Customized Panels | 400 Lab Panels | Dynamic Tracking | Functional & Clinical Reference Ranges

UnCraveRx

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Booth #1043

BioCorRx, Inc., 2390 E. Orangewood Ave., Ste.575, Anaheim, CA, 92806, US Ph: (833) 4-UnCrave Email: donnie@biocorrx.com • Website: www.uncraverx.com UnCraveRx is a medically-assisted weight loss program that includes sustained-release naltrexone therapy known to curb cravings. This comprehensive program includes access to a virtual support platform featuring nutritional coaching and lifestyle behavioral support to help your clients create better eating habits and a healthier lifestyle.

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(Non-CME)

Margen de Inviolabilidad

Unipharma LLC

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Booth #8009

10200 NW 67th Street, Tamarac, FL, 33321, US Ph: (954) 951-2715 • Fax: (954) 721-5001 Email: earrieta@unipharmausa.com • Website: www.unipharmausa.com Unipharma was established as the world’s only purpose-built Blow-Fill-Seal (BFS) and conventional fill manufacturing facility designed with liquid and semi-liquid Rx, OTC, and Nutraceutical product capabilities.

Unipharma’s 165,000 sq. ft. (16,500 sq. meters) make it one of the largest manufacturing companies in the Southeast United States. We are launching a special line of nutraceuticals all of them presented in Liquid Unit-Dose.

University Compounding Pharmacy

•

Booth #6021

1875 3rd Ave., San Diego, CA, 92101, US Ph: (800) 985-8065 ext. 5700 • Fax: (888) 350-5494 Email: customersupport@ucprx.com • Website: www.ucprx.com UNIVERSITY COMPOUNDING PHARMACY (UCP) a nationally recognized leader in drug and device therapies. For 27 years our expert Pharmacists and experienced Physician Liaison team have been dedicated to support an unbiased product line, devising the management of BHRT conditions for your patients.

We meet FDA & BOP prescription requirements and dispense in nearly 50 states. COMPOUNDED: BIOIDENTICAL HORMONES- THYROID, PROGESTERONE, ESTROGEN, AND PDE-5 INHIBITORS.

US Biotek Laboratories

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Booth #3039

16020 Linden Ave N., Shoreline, WA, 98133, US Ph: (206) 629-5903 Email: cwinterroth@usbiotek.com • Website: www.usbiotek.com US BioTek Laboratories is an award-winning international laboratory that offers the most comprehensive food sensitivity and inhalant testing. US BioTek’s panels measure IgG, IgG4, IgA, and/or IgE reactivity across a broad range of foods and inhalants. In addition, US BioTek offers the most convenient collection methods for Organic Acids and Environmental Pollutants via dried urine. US BioTek is here for you to assist you in all your testing needs.

Venus Concept

•

Booth #7073

235 Yorkland Blvd, 9th Floor, Toronto, ON, M2J 4Y8, CA Ph: (888) 907-0115 Email: info@venusconcept.com • Website: www.venusconcept.com Venus Concept is a global leader in the aesthetic and medical device industries. We offer cutting-edge platforms for today’s most in-demand aesthetic needs, including NeoGraft® for hair restoration, as well as medical technologies, like Venus Heal™ for soft tissue injuries. Venus Concept also offers the industry’s only subscription acquisition plan.

Vibrant America

•

Booth #7100

Vibrant America Clinical Laboratory, 1021 Howard Avenue Ste B, San Carlos, CA, 94070, US Ph: (866) 364-0963 Email: support@vibrant-america.com • Website: www.vibrant-wellness.com Vibrant Wellness is a leading science and technology company delivering life-transforming laboratory services using an integrated microarray platform that enables multiplex testing at an affordable cost.

Vidya Herbs Inc

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Booth #6060

331 Newman Springs Road Bld. 1, 4th Flr., Ste 143, Red Bank, NJ, 07701, US Ph: (732) 784-1587 Email: info@vidyaherbsusa.com • Website: www.vidyaherbsusa.com Vidya Herbs is a worldwide natural ingredients manufacturer founded in 2004 and dedicated to the research and development, production, marketing and sales of high quality botanical ingredients (plant extracts, spices, oils, oleoresins, essential oils) and actives (clinical proven ingredients) for the Food & Beverage, Nutraceutical, and Cosmetic industries. We are headquartered in Bangalore, India, and our US sales office and warehouse are located in New Jersey and California.

ANTI - AGING MEDICAL NEWS • WINTER 2019

VIDYA HERBS INC

COMMITTED NATURE

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Vielight Inc

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Booth #9020

346A Jarvis St., Toronto, ON, CA Ph: (416) 795-9778 Email: lewlim@vielight.com • Website: www. vielight.com

The Life Light

®

Vielight is a leader in the research and development of products that improve brain functions with near infrared light (or photobiomodulation). Its devices are portable and exempted from FDA regulations, being considered as low-risk, for general wellness. They have shown to be capable of modulating the brain significantly and safely in published control studies. They are now being investigated for applications in Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, cognitive performance, meditation and others.

Virtual Health Partners

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Booth #1057

106 E 19th Street, 2nd Floor, New York, NY, 10003, US Ph: (877) 586-1733 Email: info@virtualhp.com • Website: www.virtualhealthpartners.com ®

Virtual Health Partners is an innovator in health and wellness, providing condition-specific support within a contained ecosphere of care. Through a proprietary, HIPPA-compliant platform, we offer clients live, virtual nutrition, fitness, and lifestyle modification support—anywhere, anytime. Our business model provides a SaaS & PaaS solution that is offered exclusively to users through our network of participating partners, including Hospital Systems, Medical Device, Pharmaceutical, Nutrition Supplement, Insurance and Fitness Companies.

Vita Aid Professional Therapeutics enticity.ca

•

Booth #8042

20285 Stewart Crescent Unit 302, Maple Ridge, BS, V2X 8G1, CA Ph: (800) 490-1738 • Fax: (604) 465-1299 Email: info@vitaaid.com • Website: www.vitaaid.com With 20+ years of experience in the natural health industry, Vita Aid Professional Therapeutics strives to provide high-quality and effective nutraceuticals for health care practitioners worldwide. We focus on products for professional, safe, and effective therapeutic use and follow strict pharmaceutical-grade standards. What differentiate Vita Aid from others are: •Exclusive to health care practitioners •Clinical evidence based formulation •No added stearic lubricants – for higher bioavailability of the active ingredients •Vegetarian formulas

Vitafor

•

Booth #6073

Estrada Dr. Celso Charuri- 405, Aracoiaba Da Serra, BR27, 18190, BR Ph: (55) 15-99604 8188 Email: comex@vitafor.com.br • Website: www.vitafor.com.br A privately owned company with no foreign investment or capital, VITAFOR was founded in 2005 as a dietary supplement manufacturer committed and dedicated to the principles of tradition, innovation and research. Founded on the modern application of standardized ingredients, VITAFOR has established itself as a manufacturer of high quality nutraceuticals whose mission is to provide natural products for human nutrition and well being. VITAFOR produces over 140 finished products and privately supports several clinical studies in conjunction with prestigious Brazilian academic and scientific institutions in a brand new manufacturing, R&D and/or distribution facility.

Vital Nutrients

•

Booth #2045

45 Kenneth Dooley Dr, Middletown, CT, 06457, US Ph: (888) 328-9992 Email: support@vitalnutrients.net • Website: www.vitalnutrients.net Vital Nutrients is dedicated to manufacturing high quality supplements that promote health, wellness and vitality. Our stringent standards and extensive laboratory analyses has led to our supplements being used and trusted by hospitals, healthcare practitioners and consumers worldwide. Nothing is more important than the quality of our supplements.

Vital USA Inc.

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Booth #1035

525 S. Flagler Dr., Ste.301, West Palm Beach, FL, 33041, US Ph: (561) 282-6074 Email: mark.buscemi@vvvital.com • Website: www.vvvital.com We are a company that is focused on information Information that is essential to living a life of great health and wellness. Information that is accessible on demand. Information that will allow consumers and caregivers to monitor their well being easily. Information that empowers consumers and caregivers to manager their health on their own terms.

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Viveve, Inc.

•

Booth #3079

345 Inverness South, Bldg.B, Ste.250, Englewood, CO, 80112, US Ph: (480) 206-1874 Email: marketing@viveve.com • Website: www.viveve.com Viveve Inc. is a women’s intimate health company improving women’s quality of life with Viveve Solutions.

The Viveve System, with its cryogen-cooled monopolar radiofrequency (CMRF) technology, delivers a single-session, in-office treatment cleared in over 50 countries to treat vaginal laxity and/or improve sexual function; it is available in the US for electrocoagulation and hemostasis in general surgery. InControl Products by Viveve are at-home use medical devices that strengthen the pelvic floor to treat incontinence.

ViviscalPRO

•

Booth #1046

500 Charles Ewing Blvd, Ewing, NJ, 08628, US Ph: (702) 789-3690 Email: info@viviscalprofessional.com • Website: www.viviscalprofessional.com Viviscal Professional is a 100% drug free nutraceutical that nourishes hair follicles from the inside out with the proprietary AminoMar® marine complex. Available exclusively in salons and doctors’ offices, the effectiveness of this #1 clinically proven supplement is backed by numerous clinical trials and more than 25 years of continuous research and development.

WAVi Co.

•

Booth #1066

3535 South Irving Street, Denver, CO, 80110, US Ph: (713) 823-1945 Email: info@wavimed.com • Website: www.wavimed.com WAVi is a multifaceted brain assessment tool. WAVi makes it possible for those proactively seeking to improve brain health to measure the effectiveness of their efforts. Having proved itself useful in the clinical research realm, the practical applications of WAVi have expanded greatly over the last year. So much so that a new LLC, WAVi Performance, has been formed to allow WAVi to explore human performance optimization.

Weave

•

TM

Booth #3047

2000 Ashton Blvd., Lehi, UT, 84043, US Ph: (801) 874-6630 Email: sdrs@getweave.com • Website: www.getweave.com Weave is a communication tool that brings business owners together with their clients. Yes, Weave gives you advanced texting, automated reminders, email marketing tools, reviews and more-- but we also give you an unparalleled, relationship-building solution for your office.

Wells Pharmacy Network

•

Booth #4015

3420 Fairlane Farms Rd., Ste.300, Wellington, FL, 33414, US Ph: (800) 622-4510 Email: info@wellsrx.com • Website: www.wellsrx.com Wells Pharmacy Network is a privately held, nationwide, compounding pharmacy specializing in solutions for wellness and anti-aging medicine including: Bio-Identical Hormone Replacement Therapy, Peptide & Regenerative Therapies, Weight Management, Sexual Wellness, Aesthetic Dermatology and Thyroid & Adrenal Health. This includes operating a 20,000SF 503A pharmacy and a 21,000SF FDA Registered 503B Outsourcing Facility that produces bulk medication. Our mission is to elevate compounding industry standards through a unique combination of superior science and service.

Women’s International Pharmacy

•

Booth #9033

2 Marsh Court, Madison, WI, 53718, US Ph: (800) 279-5708 • Fax: (800) 279-8011 Email: info@womensinternational.com • Website: www.womensinternational.com Women’s International Pharmacy specializes in custom compounded bioidentical hormone prescriptions for men and women. Our pharmacy earned accreditation through the Pharmacy Compounding Accreditation Board (PCAB) by following stringent proficiency and quality assurance standards. Our pharmacists focus on meeting individual needs for licensed medical practitioners and their patients. Whether you are a practitioner or patient you can be assured Women’s International Pharmacy is here for you and we respect your freedom of informed personal choice.

ANTI - AGING MEDICAL NEWS • WINTER 2019

191

WorldHealth.net

•

Booth #2102

6481 Abbotsford House Court, Las Vegas, NV, 89130, US Ph: (702) 613-9176 Email: members@worldhealth.net • Website: www.worldhealth.net WorldHealth.Net is a not for profit trusted source of non-commercial medical information, the official voice of the A4M and the anti-aging/regenerative medical specialty. We have published breakthrough clinical/science news since inauguration in 1996 by senior editor Dr. Ronald Klatz, founder of the antiaging movement. Join WHN now to benefit from new patient referrals and the ability to publish and receive citations for your contributions to the fastest growing new medical specialty.

XYMOGEN

•

Booth #2075

6900 Kingspointe Parkway, Orlando, FL, 32819, US Ph: (407) 722-8876 Email: melissa.camacho@xymogen.com • Website: www.xymogen.com XYMOGEN, a family-owned health sciences company, has been providing high-quality dietary supplements to licensed health care practitioners for more than a quarter century. The nutraceutical company has introduced numerous innovations to the functional medicine community; XYMOGEN’s Medical Board of Advisors consists of clinical practitioners who are industry experts in a broad range of specialties. The company’s 308,400 square-foot manufacturing and fulfillment facilities are GMP (good manufacturing practices) and registered by NSF International.

Y Lift

•

Booth #5033

61 East 66th Street, First Floor, New York, NY, 10065, US Ph: (212) 861-7787 Email: info@ylift.com • Website: www.ylift.com Founded and developed by Dr. Yan Trokel, a board certified surgeon specializing in facial aesthetics, the Y LIFT® is a patented and revolutionary non-surgical facial contouring procedure based on three tenets: Structural Volumizing®, Closed Facelift®, and the Leading Edge®. Y LIFT® restores youthful facial contours by replenishing lost volume in specific anatomic layers and zones utilizing a specialized anatomically correct marking device and methodology resulting in instant and dramatic rejuvenation of the face and upper neck.

Zimmer MedizinSystems

•

Booth #6064

3 Goodyear Suite B, Irvine, CA, 92618, US Ph: (800) 327-3576 • Fax: (949) 727-2154 Email: info@zimmerusa.com • Website: www.zimmerusa.com Zimmer MedizinSystems in Irvine, California, with its parent company in Neu-Ulm, Germany, is celebrating 50 years of expertise in manufacturing high quality medical devices. Zimmer MedizinSystems’ flagship products, Z Wave and Z Cryo, utilize advanced Radial Pulse Therapy and Cryo Therapy technologies. The company has set the gold standard for Cryotherapy and skin cooling systems and is introducing the new water-cooled and ultra-quiet Z Wave Q.

Zingit Solutions

•

Booth #4095

200 N. Fairway Drive, Ste. 174, Vernon Hills, IL, 60061, US Ph: (866) 587-5572 Email: sales@zingitsolutions.com • Website: www.zingitsolutions.com Excellent communication gets patients into your practice, gives them a good experience, and keeps them coming back. Without excellent communication, patients miss appointments, become dormant or never find you in the first place—and practice growth fizzles. Zingit automates 2-way conversations, ending the voicemail “leave a message” cycle and reaching patients on mobile.Automated and integrated, Zingit rapidly fills the calendar, gets reviews, delivers videos, recalls, reminds, sends birthday videos, helps with missed appointments and more!

ZRT Laboratory

•

Booth #7005

8605 SW Creekside Pl., Beaverton, OR, 97008, US Ph: (503) 597-1884 • Fax: (503) 466-1636 Email: krwiencek@zrtlab.com • Website: www.zrtlab.com ZRT Laboratory is a CLIA-certified commercial and research laboratory founded in 1998 by breast cancer researcher David Zava, Ph.D. ZRT has pioneered innovative testing methods for hormones, neurotransmitters, heavy metals and more, offering health care professionals convenient testing options in different body fluids including saliva, dried blood spot, dried urine, and serum. With over 10 million clinical tests performed over the past 20+ years, coupled with our signature personalized test report, ZRT Laboratory has become a world recognized leader in clinical testing.

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193

ZyCal Bioceutials Healthcare Co., Inc.

Regenerative Tissue Science, LLC. NATURAL BIOACTIVE PROTEINS A Subsidiary of ZyCal Bioceuticals Healthcare Company, Inc.

•

Booth #8060

5 Executive Drive, Suite A, Toms River, NJ, 08755, US Ph: (888) 779-9225 • Fax: (888) 373-0594 Email: marketing@zycalbio.com • Website: www.rts.ostinol.com Regenerative Tissue Science, LLC. (RTS) is a healthcare professional only company, focused on stem cell and tissue regeneration through natural, bio-active proteins. RTS, is committed to the education and distribution of breakthrough products with proven scientific and clinical data, leading the way in natural, regenerative medicine with its flagship product Ostinol™ Advanced Bone and Cartilage Stimulating Proteins. Ostinol™ brand products are powered by Cyplexinol® - Nature’s BMP-Complex, the only natural stem-cell activating ingredient.

ZYTO

•

Booth #1033

1172 W 700 N STE 300, Lindon, UT, 84042, US Ph: (801) 224-7199 Email: info@zyto.com • Website: www.zyto.com The ZYTO Hand Cradle measures the body’s galvanic skin response to various questions presented in the form of digital signature that the body answers directly. The software analyzes this data to produce an easy-to-read report that ranks items whose corresponding digital signatures resulted in greater biological coherence, or preference.

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IV Therapy & Chelation SYMPOSIUM

October 16-17 | Charleston, SC

Join us for an intensive symposium on IV Therapy Learning Objectives • Describe how to safely administer IV therapy and assess patient progress

FACULTY:

Dorothy Merritt MD

• Review diagnostic and evaluation testing requirements • Discuss compatible combinations of solutions and potential complications

Deepa Verma MD

• Discuss vitamins, minerals, and amino acids, and learn how to create targeted IV therapies • Study chelation therapy and specifics on how to remove toxic heavy metals

SAVE $100 Onsite Only

MAY

OCTOBER

Gaylord Palms Orlando, FL

Belmond Charleston Place Charleston, SC

Spring Congress May 14-16 ABAARM & ABAAHP Written Exams May 13

FEBRUARY/MARCH Terranea Resort Rancho Palos Verdes, CA BHRT Symposium February 27-29

ABAARM Oral Exams May 14-16 Module I - Endocrinology May 14-16 Module V: Clinical Intensives May 14-16

Module IV: Gastroenterology October 15-17 Module VIII: Weight Management October 15-17 IV Therapy Symposium October 16-17 Pellet Therapy October 16-17

Module XVI C: Advanced Cardio May 14-16

Module II - Cardiology February 27-29 Module VI - Mitochondrial Restoration February 27-29 Peptide I February 27-28

DECEMBER

Peptide II February 29-March 1

SEPTEMBER

Venetian/Palazzo Las Vegas, NV

Boston Park Plaza Boston, MA

World Congress December 11-13

BHRT Symposium September 9-12 ABAARM & ABAAHP Exams September 9-12 Module III: Neurology September 10-12 Module VII: Autoimmune September 10-12

561.997.0112

www.a4m.com

Peptides III September 10-11 Peptides IV September 12-13

ABAARM & ABAAHP Written Exams December 10 ABAARM Oral Exams December 11-13 Module I - Endocrinology December 11-13 Module V: Clinical Intensives December 11-13 Module XVI D: Advanced Cardio December 11-13