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Dear Longevity Leaders,

Not long ago, aging was treated as fate. The province of genetics, luck, and circumstance – an inevitable decline for which intervention was limited and largely reactive. Not long ago, medical knowledge was scarce and hard-earned –acquired through years of disciplined study. Expertise ensured authority. Authority ensured trust.

And not so long ago, the specialty you now proudly practice – respected today across the globe – was considered fringe, operating outside the boundaries of conventional medicine.

How quickly that has changed.

The global longevity economy has reached a valuation of nearly $800 billion and is projected to surpass $1.4 trillion within the next five years. Investment in the sector has doubled year over year, while a demographic certainty looms: by 2030, one in four adults in advanced economies will be over 60. Demand for sophisticated, longevityfocused care already exceeds the supply of practitioners prepared to deliver it at scale.

At the same time, technological acceleration has transformed access and expectations. Diagnostic, analytical, and monitoring capacities have multiplied. Scientific data now circulates freely, only to be summarized, then reposted. Swiftly inserting itself into daily life, artificial intelligence has collapsed the distance between discovery and interpretation. We are witnessing a new democratization of access – often without context, guardrails, or consequences.

And yet the most striking development is not even technological. It is cultural. Human.

Research tracking millions of consumer conversations reveals that the locus of control has shifted inward. Patients have never had greater access to information or a stronger sense of ownership over their health decisions. Where providers were once the primary interpreters of specialized knowledge, today’s patients arrive having already interpreted it themselves. AI-empowered and often disillusioned with traditional systems, they no longer wait for institutional permission to intervene.

The gates have opened. And while the longevity movement is expansive, it is still fundamentally leaderless. For practitioners like you – driven, educated, committed to excellence as standard – that is an invitation.

One we eagerly extend. As the distance between providers and patients narrows, your role in their lives has never been more essential. You are uniquely positioned at the intersection of market demand, scientific advancement, and professional credibility. You possess what algorithms cannot replicate: judgment, wisdom, experience, ethics, and the ability to translate them all into individualized care in service of a lasting partnership.

In an age of infinite information, no matter the breakthroughs or shifting tides, the locus of control ultimately returns to you.

Because all of medicine resolves in one encounter, with a patient sitting across from someone they trust. In that moment, the future of our field and the future of that patient become inseparable.

The trajectory of both depends on those who guide them.

We are honored to welcome you to Longevity SpringFest 2026. May your time here reaffirm the extraordinary impact of the work you have chosen to pursue.

In shared purpose,

Ronald Klatz MD, DO Co-Founder

Robert Goldman MD, PhD Co-Founder

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WORKSHOPS (NON-CME)

FRIDAY, APRIL 10TH

6:15 PM | LOCATION: Ballroom A

Brain Energy, Aging, and Injury: Targeting

Metabolic Constraints in Older Adults

PRESENTED BY: Dominic D’Agostino, PhD

Brain Energy, Aging & Injury

Targeting Metabolic Constraints in Older Adults

Dr. Dom D’Agostino shares a practical, evidenceinformed framework to support healthy brain aging and improve fall and concussion recovery.

• Identify metabolic constraints that impact brain resilience and recovery

• Apply guideline-aligned rehab principles to falls/concussion cases

• Use metabolomics + lipid and nutrient markers to personalize next steps

Join this non-CME workshop Friday, April 10th at 6:15pm in Ballroom A

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Dr. Dom D’Agostino

gdx.net/a4m is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. His research program focuses on metabolic and nutritional strategies that support brain and systemic resilience across aging, neurological injury, and chronic disease, including work on oxidative stress, mitochondrial function, metabolomics, and performance physiology.

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METABOLIC DYSFUNCTIONASSOCIATED FATTY

LIVER DISEASE: Epidemiology, Pathogenesis, Disease Progression, and Unmet Needs

By: Gareth Morris-Stiﬀ, MBBCh, MD, MCh, PhD, FRCS, FACS

Abstract

Metabolic dysfunction–associated fatty liver disease (MAFLD), recently reframed within the broader nomenclature of metabolic dysfunction-associated steatotic liver disease (MASLD), represents the hepatic manifestation of systemic metabolic dysfunction. MAFLD has emerged as the most prevalent chronic liver disease worldwide and is now a leading cause of cirrhosis, hepatocellular carcinoma (HCC), and is the second commonest indication for liver transplantation. The transition from non-alcoholic fatty liver disease (NAFLD) to MAFLD reﬂects a conceptual shift away from exclusionary definitions toward positive diagnostic criteria centered on metabolic risk. This review provides a comprehensive synthesis of current knowledge regarding the global incidence and prevalence of MAFLD, its etiologic determinants, and the molecular and cellular mechanisms that drive disease initiation and progression. Particular emphasis is placed on the transition from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), progressive fibrosis, cirrhosis, and hepatocellular carcinoma. We highlight key advances in genetics, metabolomics, proteomics, and gut-liver axis biology, alongside emerging data on dietary drivers such as

ultra-processed foods and artificial sweeteners. Finally, we identify major gaps in knowledge that continue to hinder effective prevention, risk stratification, and therapeutic development.

Introduction and Evolution of Nomenclature

Fatty liver disease not attributable to excessive alcohol consumption has historically been referred to as non-alcoholic fatty liver disease (NAFLD). While this term provided a practical framework for decades, it defined the condition largely by exclusion and implied a homogeneity that does not reﬂect biological reality. Accumulating epidemiologic, clinical, and mechanistic data have demonstrated that NAFLD is deeply embedded within the spectrum of metabolic disease and is rarely an isolated hepatic disorder.

The close association between hepatic steatosis and obesity, insulin resistance, type 2 diabetes mellitus (T2DM), dyslipidemia, hypertension, and cardiovascular disease led to growing dissatisfaction with the NAFLD construct. In particular, the exclusion of alcohol intake as a defining criterion was increasingly viewed as

The following article is not endorsed and/or supported by The American Academy of Anti-Aging Medicine. The purposes of this publication do not imply endorsement and/or support of any author, company or theme related to this article.

arbitrary, given that modest alcohol consumption often coexists with metabolic risk factors and may not be the dominant driver of liver injury in many patients. Furthermore, NAFLD failed to capture the substantial heterogeneity in disease progression, clinical outcomes, and extrahepatic complications.

In response, an international consensus group proposed the term metabolic dysfunction-associated fatty liver disease (MAFLD), later harmonized into metabolic dysfunction-associated steatotic liver disease (MASLD). This revised nomenclature emphasizes positive diagnostic criteria based on the presence of hepatic steatosis and metabolic dysfunction, rather than the absence of alcohol or other liver diseases. Importantly, MAFLD acknowledges the frequent coexistence of multiple hepatic insults and reframes fatty liver disease as a multisystem disorder with hepatic and extrahepatic consequences.

The adoption of MAFLD/MASLD has significant implications. Epidemiologically, it broadens the recognized disease population and improves alignment with real-world clinical practice. Conceptually, it strengthens the biological rationale linking hepatic steatosis to cardiometabolic risk. From a research perspective, it facilitates more inclusive clinical trial design and may improve patient engagement by shifting away from stigmatizing terminology.

Global Incidence and Prevalence

Worldwide Burden

MAFLD is now recognized as the most common chronic liver disease globally. Pooled analyses suggest that approximately 30–35% of adults worldwide have imaging or biomarker evidence of hepatic steatosis consistent with MAFLD, corresponding to well over one billion individuals. Prevalence varies markedly by region, reﬂecting differences in genetic background, dietary patterns, urbanization, and socioeconomic factors.

The highest prevalence rates have been reported in the Middle East, North Africa, and South America, where estimates frequently exceed 40%. In the US, the prevalence is currently in the order of 40% and is predicted to exceed 50% by 2035. Historically lowerprevalence regions such as East and South Asia are experiencing the most rapid growth, driven by nutritional transition, reduced physical activity, and increasing rates of central obesity even at relatively low body mass indices.

Importantly, the burden of MAFLD extends beyond simple prevalence. Modeling studies incorporating demographic trends and metabolic risk projections predict a disproportionate increase in advanced disease stages, including MASH, cirrhosis, and HCC, over the coming decades. These projections raise substantial

Global prevalence of MAFLD - Courtesy of Feng et al. JHEP Reports (2025)

concerns regarding future demand for hepatology services, transplantation, and cancer care.

Incidence, Age, and Sex Eﬀects

Incidence data for MAFLD are less robust than prevalence estimates but provide important insights into disease dynamics. Longitudinal cohort studies suggest annual incidence rates of 20-50 per 1,000 person-years among individuals with obesity or metabolic syndrome. Incidence increases progressively with age and is strongly associated with baseline insulin resistance and visceral adiposity.

Sex differences are evident across the disease spectrum. Men exhibit higher incidence and prevalence during early and middle adulthood, likely reﬂecting sex differences in fat distribution, sex hormones, and lifestyle exposures. However, the protective effect observed in premenopausal women diminishes after menopause, resulting in convergence of prevalence and progression rates in older age groups. Indeed, women with MAFLD at the time of menopause exhibit a rapid progression of their disease towards MASH and cirrhosis.

Ethnicity and Socioeconomic Determinants

Ethnic disparities in MAFLD prevalence and severity are well described. Individuals of Hispanic ancestry demonstrate the highest prevalence and more severe disease, whereas individuals of African ancestry exhibit lower prevalence despite similar or greater burdens of obesity and insulin resistance. These differences are partly explained by genetic variation, particularly

in PNPLA3, but also reﬂect environmental and socioeconomic factors.

The same genetic mutation is believed to be culprit in the “golden crescent” region extending from the Middle East through Pakistan and also the population of India and Bangladesh. A 2025 study from Hyderabad documented a staggering 84% prevalence of MAFLD amongst IT workers.

Lower socioeconomic status is consistently associated with higher MAFLD prevalence and worse outcomes, likely mediated by reduced access to healthy foods, higher consumption of ultra-processed products, limited opportunities for physical activity, and disparities in healthcare access.

Etiology and Risk Factors

Metabolic Dysfunction as the Central Driver

At its core, MAFLD is a manifestation of systemic metabolic dysfunction. Insulin resistance plays a pivotal role by altering lipid ﬂux and glucose metabolism across multiple tissues. In adipose tissue, impaired insulin signaling promotes enhanced lipolysis, increasing circulating free fatty acids delivered to the liver. Simultaneously, hepatic insulin resistance fails to suppress gluconeogenesis while preserving insulin-driven de novo lipogenesis, resulting in net lipid accumulation.

Hyperinsulinemia, hyperglycemia, and dyslipidemia further exacerbate hepatic fat deposition and create a metabolic milieu conducive to oxidative stress, inﬂammation, and cellular injury. Importantly, these processes are self-reinforcing, establishing a vicious cycle that drives disease progression.

Obesity and Adipose Tissue Dysfunction

Obesity, particularly central or visceral obesity, is among the strongest risk factors for MAFLD. However, increasing recognition of MAFLD in individuals with normal BMI, the so-called “skinny fat”, underscores the importance of adipose tissue quality rather than quantity alone. Dysfunctional adipose tissue

is characterized by adipocyte hypertrophy, hypoxia, macrophage infiltration, and altered adipokine secretion.

Reduced adiponectin levels impair hepatic fatty acid oxidation and anti-inﬂammatory signaling, while elevated leptin and pro-inﬂammatory cytokines promote fibrogenesis. These adipose-derived signals exert profound effects on hepatic metabolism and immune activation, linking obesity to progressive liver injury.

Dietary Drivers: Sugars, Ultra-Processed Foods, and Sweeteners

Dietary composition is a modifiable and increasingly scrutinized determinant of MAFLD risk. High intake of fructose-containing sugars, particularly from sugarsweetened beverages, is strongly associated with hepatic steatosis and fibrosis. Fructose metabolism bypasses key regulatory steps in glycolysis, favoring lipogenesis, ATP depletion, and uric acid production, thereby promoting oxidative stress and inﬂammation.

Ultra-processed foods represent an emerging and particularly concerning dietary exposure. Large prospective cohorts have demonstrated robust associations between ultra-processed food intake and MAFLD. These foods are typically energy dense, low in fiber, and rich in additives, emulsifiers, and refined carbohydrates. Mechanistic studies implicate systemic

inﬂammation, adverse lipid profiles, insulin resistance, and gut microbiome perturbations as mediators of harm.

Artificial sweeteners and diet beverages were initially promoted as healthier alternatives to sugar-sweetened products. However, growing evidence suggests potential adverse metabolic effects, including altered glucose homeostasis, increased appetite, and gut dysbiosis. Observational studies have linked high consumption of artificially sweetened beverages to MAFLD and MASH, though residual confounding and reverse causality remain important considerations.

Genetic Susceptibility and Epigenetic Regulation

Genetic factors substantially influence individual susceptibility to MAFLD and its progression. The PNPLA3 I148M variant is the most robustly validated genetic determinant, conferring increased hepatic fat accumulation, inflammation, fibrosis, and HCC risk independent of metabolic factors. Variants in TM6SF2 impair very-low-density lipoprotein secretion, while MBOAT7 and GCKR variants influence phospholipid remodeling and glucose metabolism, respectively.

Epigenetic mechanisms provide a dynamic interface between genes and environment. DNA methylation patterns, histone modifications, and non-coding RNAs modulate the expression of genes involved in lipid metabolism, inﬂammation, and fibrogenesis. These processes may underlie interindividual variability in disease trajectory and represent promising avenues for biomarker development.

The Gut-Liver Axis

The gut–liver axis has emerged as a central component of MAFLD pathogenesis. Dysbiosis alters bile acid composition, reduces intestinal barrier integrity, and increases translocation of microbial products such as lipopolysaccharide. These signals activate hepatic innate immune pathways, amplifying inﬂammation and fibrogenesis.

Microbiota-derived metabolites, including short-chain fatty acids, ethanol, and secondary bile acids, inﬂuence insulin sensitivity, lipid metabolism, and hepatic stellate cell activation. Dietary patterns, antibiotics, and host genetics shape the microbiome, highlighting the gut–liver axis as a potential therapeutic target.

Pathogenesis of Hepatic Injury

Steatosis, Lipotoxicity, and

Organelle Stress

Hepatic steatosis represents the earliest and most common manifestation of MAFLD. Initially, triglyceride accumulation may serve as a relatively inert storage mechanism. However, excessive accumulation of free fatty acids and toxic lipid species such as diacylglycerols and ceramides induces lipotoxicity.

Lipotoxic stress disrupts mitochondrial function, leading to impaired β-oxidation and increased reactive oxygen species generation. Concurrent endoplasmic reticulum stress activates unfolded protein responses, further promoting hepatocyte injury and apoptosis.

Inﬂammation and Immune Activation

Hepatocyte injury releases damage-associated molecular patterns that activate Kupffer cells and recruit monocytes, neutrophils, and lymphocytes. These immune cells produce pro-inﬂammatory cytokines and chemokines that perpetuate insulin resistance and hepatocellular damage. Chronic low-grade inﬂammation is a defining feature of MASH and distinguishes it from simple steatosis.

Fibrogenesis and Matrix Remodeling

Persistent inﬂammation and hepatocyte injury activate hepatic stellate cells, transforming them into collagenproducing myofibroblasts. Progressive extracellular matrix deposition disrupts sinusoidal architecture, impairs hepatic perfusion, and increases portal pressure. Fibrosis progression is heterogeneous, but fibrosis stage is the strongest predictor of liver-related and overall mortality in MAFLD.

Progression to MASH, Cirrhosis, and Hepatocellular Carcinoma

Metabolic Dysfunction-Associated Steatohepatitis

MASH represents the inﬂammatory and fibrogenic form of MAFLD and is characterized histologically by steatosis, hepatocyte ballooning, lobular inﬂammation, and variable fibrosis. Approximately 20-30% of individuals with MAFLD develop MASH, with higher risk among those with T2DM, obesity, and genetic susceptibility.

Cirrhosis and Decompensation

Advanced fibrosis may progress to cirrhosis, marked by architectural distortion, portal hypertension, and impaired hepatic function. MAFLD-related cirrhosis is now among the leading indications for liver transplantation globally, and is the second most common in the US. Decompensation manifests as ascites, variceal hemorrhage, hepatic encephalopathy, and hepatocellular insufficiency, with high morbidity and mortality.

Hepatocellular Carcinoma

MAFLD is an increasingly important cause of HCC, including cases arising in non-cirrhotic livers. Metabolic inﬂammation, oxidative stress, altered lipid signaling, and dysregulated growth pathways contribute to hepatocarcinogenesis. Given the large at-risk population, MAFLD-associated HCC represents a major and growing public health challenge, often diagnosed at advanced stages due to lack of systematic surveillance.

MAFLD as a Multisystem Disease: Extrahepatic Manifestations and Systemic Consequences

MAFLD is increasingly recognized not merely as a liver disease, but as a systemic disorder with profound effects on multiple organs. Indeed, extrahepatic complications are the leading causes of morbidity and mortality in individuals with MAFLD, often exceeding liver-related outcomes. The liver occupies a central position in metabolic homeostasis, lipid handling, glucose regulation, inflammation, and endocrine signaling. When

hepatic metabolism becomes dysregulated, downstream effects propagate across organ systems through altered lipid fluxes, cytokine release, hepatokines, and shared cardiometabolic risk pathways.

Cardiovascular Disease

Cardiovascular disease (CVD) is the leading cause of death in patients with MAFLD, accounting for a substantially greater proportion of mortality than liver-related complications. Numerous epidemiologic studies demonstrate that MAFLD is independently associated with coronary artery disease, heart failure, atrial fibrillation, and stroke, even after adjustment for traditional cardiovascular risk factors.

Mechanistically, MAFLD contributes to atherogenesis through multiple pathways. Hepatic insulin resistance promotes atherogenic dyslipidemia characterized by elevated triglycerides, increased small dense LDL particles, and reduced HDL cholesterol. Chronic lowgrade inflammation originating from the steatotic liver leads to systemic endothelial dysfunction and vascular inflammation. In addition, altered secretion of hepatokines such as fetuin-A, fibroblast growth factor 21, and angiopoietin-like proteins modulates insulin sensitivity, vascular tone, and lipid metabolism.

Advanced fibrosis appears to confer particularly high cardiovascular risk, suggesting that disease severity matters. Importantly, MAFLD identifies a population at heightened cardiovascular risk that may not be fully captured by conventional risk calculators, underscoring the need for integrated cardiometabolic risk assessment in this population.

Brain Function and Neurocognitive Health

Emerging evidence links MAFLD to adverse brain outcomes, including cognitive impairment, dementia, and cerebrovascular disease. Insulin resistance, systemic inflammation, and altered lipid metabolism are shared pathogenic mechanisms between MAFLD and neurodegenerative disorders. Neuroimaging studies suggest associations between hepatic steatosis and reduced brain volume, white matter integrity, and cerebral perfusion.

The liver-brain axis is mediated in part by inflammatory cytokines, ammonia handling, and altered bile acid signaling, which may influence neuroinflammation and neuronal function. Additionally, MAFLD is associated with obstructive sleep apnea, depression, and reduced quality of life, further compounding neurocognitive burden.

Skeletal Muscle and Sarcopenia

Skeletal muscle plays a critical role in glucose disposal and whole-body insulin sensitivity. MAFLD is closely linked to sarcopenia and myosteatosis, conditions characterized by reduced muscle mass, strength, and quality. Loss of skeletal muscle exacerbates insulin resistance and promotes hepatic fat accumulation, creating a bidirectional relationship between muscle and liver.

Patients with MAFLD and sarcopenia exhibit higher rates of MASH, advanced fibrosis, and mortality. Mechanistically, chronic inflammation, altered amino acid metabolism, mitochondrial dysfunction, and physical inactivity contribute to muscle loss. Recognition of the muscle-liver axis highlights the importance of resistance training and preservation of lean mass as therapeutic strategies.

Bone Metabolism and Osteoporosis

An emerging body of literature suggests that MAFLD is associated with reduced bone mineral density and increased fracture risk. Hepatic insulin resistance and chronic inflammation impair osteoblast function while promoting osteoclast activation. Altered vitamin D metabolism, reduced physical activity, and sarcopenia further contribute to skeletal fragility.

Hepatokines and adipokines also influence bone remodeling, suggesting complex endocrine crosstalk between liver, adipose tissue, and bone. Although data are heterogeneous, the potential link between MAFLD and osteoporosis warrants increased clinical awareness, particularly in older adults.

Chronic Kidney Disease

MAFLD is independently associated with chronic kidney disease (CKD), including reduced estimated glomerular

filtration rate and albuminuria. Shared risk factors such as insulin resistance, hypertension, and systemic inflammation contribute to renal injury. However, MAFLD itself may exacerbate renal dysfunction through increased oxidative stress, activation of the renin–angiotensin system, and dysregulated lipid metabolism.

Severity of liver disease correlates with CKD risk, and MAFLD-associated fibrosis appears to be a strong predictor of renal outcomes. These observations support a bidirectional liver-kidney axis and highlight the need for renal surveillance in patients with MAFLD.

Intestinal Function and the Gut Barrier

The intestine is a critical mediator of MAFLD pathogenesis and progression. Increased intestinal permeability or “leaky gut” facilitates translocation of microbial products that activate hepatic innate immunity. Altered bile acid signaling affects not only hepatic metabolism but also intestinal motility, microbial composition, and nutrient absorption.

Dietary patterns common in MAFLD, including high intake of ultra-processed foods and artificial sweeteners, further disrupt gut microbial ecology. These changes may amplify systemic inflammation and metabolic dysfunction, reinforcing disease progression.

Adipose Tissue as an Endocrine Organ

Adipose tissue dysfunction lies at the heart of MAFLD and its systemic consequences. Inflamed visceral

adipose tissue secretes excess free fatty acids and proinflammatory cytokines that drive hepatic steatosis and insulin resistance. Adipokine imbalance alters appetite regulation, energy expenditure, vascular health, and immune function.

The reciprocal communication between adipose tissue and liver positions MAFLD as a nodal disease within a broader network of metabolic organ dysfunction.

Knowledge Gaps and Unmet Needs

Despite progress, substantial gaps remain. Optimal population screening strategies are undefined, and these are required to identify early those with MAFLD to allow institution of behavioral changes. The long-term hepatic and systemic effects of artificial sweeteners and ultra-processed foods require clarification through mechanistic and interventional studies. Integration of omics data into clinical practice remains challenging, and effective combination therapies addressing both metabolic dysfunction and hepatic injury are still lacking.

Future Directions

Future efforts should prioritize prevention through public health interventions, precision medicine approaches incorporating genetic and metabolic risk, and multidisciplinary care models. Large, diverse longitudinal studies are essential to refine risk stratification, guide therapeutic development, and ultimately reduce the global burden of MAFLD.

Histologic progression from steatosis to MASH, cirrhosis, and HCC – Adapted from Younossi et al. Hepatol (2023) * and Velliou et al. Cell Mol Life Sci (2023) **

Essential References for Further Reading

1. Rinella ME, Lazarus JV, Ratziu V, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. J Hepatol. 2023 Dec;79(6):1542-1556.

2. Feng G, Targher G, Byrne CD, et al. Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021. JHEP Rep. 2024 Nov 14;7(3):101271.

3. Younossi ZM, Golabi P, Paik JM, Henry A, Van Dongen C, Henry L. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology. 2023 Apr 1;77(4):1335-1347.

4. Le MH, Yeo YH, Zou B, et al. Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical Bayesian approach. Clin Mol Hepatol. 2022 Oct;28(4):841-850.

5. Velliou RI, Legaki AI, Nikolakopoulou P, Vlachogiannis NI, Chatzigeorgiou A. Liver endothelial cells in NAFLD and transition to NASH and HCC. Cell Mol Life Sci. 2023 Oct 5;80(11):314.

6. Hagström H, Nasr P, Ekstedt M, Kechagias S. Natural history of metabolic dysfunction–associated fatty liver disease. Nat Rev Gastroenterol Hepatol. 2024;21(2):85-99.

7. Cusi K. The role of insulin resistance and lipotoxicity in MAFLD pathogenesis. Gastroenterology. 2025;168(2):412-427.

8. Tilg H, Adolph TE, Dudek M, Knolle P. Non-alcoholic fatty liver disease: interplay between metabolism, microbiota and immunity. Nat Rev Gastroenterol Hepatol. 2021;18(12):877-895.

9. Zhao J, Lei H, Wang T, Xiong X. Liver-bone crosstalk in nonalcoholic fatty liver disease: Clinical implications and underlying pathophysiology. Front Endocrinol (Lausanne). 2023 Mar 10;14:1161402.

10. Zhao L, Clay-Gilmour A, Zhang J, Zhang X, Steck SE. Higher ultraprocessed food intake is associated with adverse liver outcomes: a prospective cohort study. Am J Clin Nutr. 2024;119(1):49-57.

11. Zhao L, Chen Y, Clay-Gilmour A, Zhang J, Zhang X, Steck SE. Metabolomic and proteomic signatures of ultra-processed foods are positively associated with adverse liver outcomes. J Nutr. 2025;155(6):1851-1858.

12. Wu Y, Tan Z, Zhen J, et al. Association between diet soft drink consumption and metabolic dysfunction–associated steatotic liver disease. BMC Public Health. 2023;23:2286.

13. Mantovani A, Petracca G, Beatrice G, Tilg H, Byrne CD, Targher G. Non-alcoholic fatty liver disease and risk of cardiovascular disease: updated meta-analysis. J Am Coll Cardiol. 2022;79(14):1441-1457.

14. Targher G, Byrne CD, Tilg H. NAFLD and increased risk of cardiovascular disease: clinical implications. Lancet Gastroenterol Hepatol. 2021;6(6):493-503.

15. Mantovani A, Zaza G, Byrne CD, Targher G. Risk of chronic kidney disease in patients with NAFLD: systematic review and metaanalysis. J Hepatol. 2020;72(5):1007-1017.

16. Liu CH, Zeng QM, Kim W, et al. Sarcopenia and MASLD: novel insights and the future. Nat Rev Endocrinol. 2026 Mar;22(3):139152.

17. Kanwal F, Kramer JR, Li L, Dai J, Yu X, El-Serag HB. Risk of hepatocellular cancer in patients with non-alcoholic fatty liver disease. Gastroenterology. 2020;158(6):1828-1837.e2.

18. Dulai PS, Singh S, Patel J, et al. Fibrosis stage and risk of mortality in nonalcoholic fatty liver disease: updated meta-analysis. Gastroenterology. 2020;159(1):223-237.e5.

19. Weinstein G, Davis-Plourde KL, Himali JJ, et al. Association of nonalcoholic fatty liver disease with cognitive decline and brain structure. Neurology. 2021;96(9):e1236-e1245.

20. Kim D, Vazquez-Montesino LM, Escobedo G, et al. Association between nonalcoholic fatty liver disease and decreased bone mineral density. J Clin Endocrinol Metab. 2021;106(9):e3723-e3732.

Become a Registered DUTCH Provider

OPTIMIZING ESTROGEN THERAPY IN

MENOPAUSE:

Why Hormone Testing Matters for Osteoporosis Prevention

By: Azra Jaferi, PhD

During menopause, a decline in estrogen accelerates bone loss and raises osteoporosis risk. Estrogen replacement therapy (ERT) can help prevent this, but only if estradiol levels reach a certain minimum threshold. While the ERT doses needed for bone protection are known for women on average, the actual estradiol level a woman gets from a given dose cannot be known unless it’s verified through hormone testing for that individual. Recent research shows that estradiol levels achieved by ERT vary widely between different transdermal forms of ERT as well as between women in how the body absorbs it. Because of this variability, average group data may not be reliable for making clinical decisions about which dose will optimize treatment outcomes (including bone protection) for a given woman. Instead, individual-level hormone testing to check each woman’s response to ERT would ensure that her estradiol levels are adequate not only for vasomotor symptom relief but also for osteoporosis prevention.

Estrogen’s role in women’s bone health

Over a woman’s life span, bone health follows a natural trajectory where bones reach peak density

in early adulthood and then plateau for several decades. Estrogen is a crucial player in the normal bone turnover cycle — promoting bone formation and inhibiting bone breakdown — ultimately helping to maintain healthy bone mineral density (BMD). However, around the time of menopause, a significant drop in estrogen precipitates a decline in BMD, increasing the risk of osteoporosis, a progressive condition where bones become structurally weak and more prone to fractures. The good news is that women can still proactively support their bone health during and after the menopausal transition through adequate nutrient intake, weight-bearing exercise, and hormone optimization. When appropriate, estrogen replacement therapy (ERT) can be a useful tool to maintain estrogen’s effects on BMD during this time. ERT is FDA-approved for the prevention of bone loss and fractures from osteoporosis in postmenopausal women.

How much estrogen is needed for bone protection?

The doses used for ERT are typically based on management of menopausal symptoms, especially vasomotor symptoms (e.g., hot ﬂashes). When a woman experiences relief of these symptoms with ERT,

it’s often presumed that the ERT dose being used is effectively providing her with enough estrogen needed to experience all benefits of ERT. But what about the benefit of bone protection? The ERT dose adequate to resolve vasomotor symptoms may not necessarily be high enough to protect bone. Relying on subjective improvement of vasomotor symptoms to determine dosing for bone protection could be misleading because of the substantial placebo effect associated with ERT.1 In order for ERT to be effective for bone preservation, the dose needs to achieve certain minimum threshold levels of estradiol and anything below those levels might be insufficient to fully prevent bone loss.2–4 For blood (serum) testing, estradiol levels of at least 20-60pg/mL may be needed; for dried urine testing, this correlates with an approximate value of 0.7-2.4ng/mg.5 Even though the specific ERT doses effective for increasing BMD have been identified for women on average,6 what is not known is the actual estradiol level delivered by any given dose in an individual patient, unless it’s verified through hormone testing for that patient.

New research continues to emerge supporting the value of individual-level testing of estradiol levels for women on ERT. For example, a recent peer-reviewed study by Precision Analytical, published in Menopause in 2023, revealed that some women on ERT will have lower levels of estradiol than other women, depending on the form that they’re using.5 The study compared estradiol levels achieved by different commonly used transdermal forms of ERT (FDA-approved gels and patches versus compounded estrogen therapy) within a large sample of postmenopausal women. The researchers measured urinary estradiol with the dried urinary sampling

method used in DUTCH Tests (where four urine samples are collected within a 24-hour period), providing a reliable estimate of the average hormone exposure over 24 hours. The results showed that compounded estrogen creams effectively delivered estradiol to the circulation, proportional to the dose used. However, FDA-approved gels and patches provided significantly higher estradiol levels with similar doses, suggesting that gels and patches might be more easily absorbed. Essentially, women using compounded creams had significantly lower estrogen exposure than women using FDA-approved gels and patches. This doesn’t necessarily mean that creams shouldn’t be used; it does, however, underscore the importance of testing estradiol levels in women using compounded creams (especially lowmid doses) and adjusting the dose accordingly to meet known bone-protective thresholds.

Reinforcing this point are independent findings from a 2025 Menopause study led by Sarah Glynne (The Portland Hospital, London), showing that a surprisingly large number of perimenopausal and postmenopausal women had low estradiol levels despite ERT use (in a sample of 1,508 women total).7 In fact, one in four women (25%) using the highest licensed dose of transdermal ERT (a 100mcg patch twice weekly or 4 pumps gel daily) had low, subtherapeutic estradiol levels, as did around 1 in 6 women using high off-label doses. These findings suggest that the prevalence of women who are “poor absorbers” of transdermal ERT is higher than previously thought. The results from these studies echo those of smaller pharmacokinetic studies demonstrating significant variability in absorption patterns between women. They reported up to 10-fold differences in estradiol levels between women using the same dose of estradiol patch or gel.4,8

Collectively, these studies show that the amount of estrogen exposure from ERT varies not only from one form of transdermal ERT to another but also between women using the same form and dose of transdermal ERT. Newman et al (2023), Menopause

Because estradiol levels with transdermal ERT can vary so much from one woman to the next, relying on data from average group-level responses to ERT could be misleading when making clinical decisions about which dose will optimize treatment outcomes (including bone protection) for a given woman. Instead, paying attention to individual-level responses to ERT for each woman would ensure that the estradiol levels achieved with ERT are adequate for osteoporosis prevention.

Hormone testing allows optimization of estrogen therapy for bone protection

The wide variability in estradiol levels with ERT makes a compelling case for implementing regular hormone testing to verify that the patient is on the right dose for her — a dose that actually provides enough estrogen to protect her bones, not just relieve hot flashes. Although hormone testing is not currently part of the standard of care for women on ERT, tailoring ERT according to each woman’s individual treatment goals is.9,10 In line with this, hormone testing allows healthcare providers to tailor ERT to the woman’s treatment goals, especially if one of the treatment goals is osteoporosis prevention.

References:

1. Zhou T. Estimation of placebo effect in randomized placebocontrolled trials for moderate or severe vasomotor symptoms: a meta-analysis. Menopause. 2023;30(1):5-10. doi:10.1097/ GME.0000000000002094

2. Reginster JY, Sarlet N, Deroisy R, Albert A, Gaspard U, Franchimont P. Minimal levels of serum estradiol prevent postmenopausal bone loss. Calcif Tissue Int. 1992;51(5):340-343. doi:10.1007/ BF00316876

3. de Lignieres B. Hormone replacement therapy: clinical benefits and side-effects. Maturitas. 1996;23 Suppl:S31-36. doi:10.1016/ s0378-5122(96)90012-2

4. Armston A, Wood P. Hormone replacement therapy (oestradiol-only preparations): can the laboratory recommend a concentration of plasma oestradiol to protect against osteoporosis? Ann Clin Biochem. 2002;39(Pt 3):184-193. doi:10.1258/0004563021902107

5. Newman MS, Saltiel D, Smeaton J, Stanczyk FZ. Comparative estrogen exposure from compounded transdermal estradiol creams and Food and Drug Administration-approved transdermal estradiol gels and patches. Menopause. Published online October 18, 2023. doi:10.1097/GME.0000000000002266

One reason why routine hormone testing during ERT may not be recommended at this time is because of the limitations of the testing medium typically used for measuring estradiol (serum testing). When serum testing of estradiol is done at a single time point, as it almost always is in clinical settings, it fails to accurately represent estradiol’s fluctuating, up-and-down pharmacokinetic pattern observed when ERT is applied on the skin.8 While serum might be a suitable method to monitor estradiol in women on a steady-state dose such as patches, it could be more challenging for transdermal applications with periodic applications such as gels and creams. Measuring estradiol in dried urine, especially with validated 4-spot collection within a 24-hour period,5 may help to average out the daily fluctuation patterns seen in serum after the application of ERT creams and gels.

To truly safeguard bone health in menopausal women on transdermal ERT, hormone testing should be embraced as a critical tool to move beyond guesswork and ensure that each woman receives the ERT dose she genuinely needs for protection against bone loss and prevention of osteoporosis.

6. Weiss SR, Ellman H, Dolker M. A randomized controlled trial of four doses of transdermal estradiol for preventing postmenopausal bone loss. Transdermal Estradiol Investigator Group. Obstet Gynecol. 1999;94(3):330-336. doi:10.1016/s00297844(99)00313-0

7. Glynne S, Reisel D, Kamal A, et al. The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study. Menopause. 2025;32(2):103-111. doi:10.1097/GME.0000000000002459

8. Järvinen A, Bäckström A, Elfström C, Viitanen A. Comparative absorption and variability in absorption of estradiol from a transdermal gel and a novel matrix-type transdermal patch. Maturitas. 2001;38(2):189-196. doi:10.1016/s0378-5122(00)00222-x

9. Stuenkel CA, Davis SR, Gompel A, et al. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(11):3975-4011. doi:10.1210/ jc.2015-2236

10. “The 2022 Hormone Therapy Position Statement of The North American Menopause Society” Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause. 2022;29(7):767-794. doi:10.1097/ GME.0000000000002028

Evaluate potential imbalances in the gut microbiome.

Mitochondrial Function

Identify inefficiencies affecting energy production and cellular health

Detoxification Capacity

Assess the body’s ability to clear toxins.

Nutrient Metabolism

Understand how efficiently the body processes vital nutrients

Neurotransmitter Support

Gain

pathways

METABOLIC ASSESSMENT AS A CORNERSTONE OF ANTI-AGING MEDICINE:

Clinical Insights from Comprehensive Urinary Biomarker Analysis

By:

Matt Pratt-Hyatt, PhD | Chief Science Officer, KBMO Diagnostics

Introduction

Comprehensive organic acid testing is a powerful tool for evaluating functional metabolism, as it provides insight into cellular energy production, nutrient utilization, gut microbial activity, detoxiﬁcation pathways, and neurotransmitter metabolism from a simple urine sample . While traditional organic acid panels offer a broad overview of metabolic byproducts and have long supported personalized clinical decision-making, newer advanced profiles build on this foundation by leveraging next-generation analytical technologies to improve sensitivity, precision, and clinical relevance. Enhanced methodologies allow for clearer detection of subtle metabolic imbalances, more consistent results, and a more integrated view of interconnected biochemical systems. With optimized marker selection and practitioner-focused reporting, advanced organic acid testing delivers more actionable insights, enabling clinicians to identify root causes with greater confidence and design more targeted, individualized interventions for complex patient presentations.

The field of anti-aging medicine seeks not merely to extend lifespan, but to preserve healthspan—the

period of life characterized by functional independence, cognitive clarity, and metabolic resilience. While chronological aging is inevitable, biological aging varies widely among individuals and is strongly inﬂuenced by metabolic efficiency, environmental exposures, nutritional status, and neuroendocrine regulation.

Traditional clinical assessments often fail to detect early biochemical dysfunction that precedes overt disease. As a result, there is growing interest in advanced metabolic evaluation tools capable of identifying subtle shifts in cellular physiology. Comprehensive urinary biomarker analysis has emerged as a valuable adjunct in anti-aging practice, offering insight into mitochondrial performance, detoxification capacity, oxidative stress burden, and neurotransmitter metabolism.

Mitochondrial Function, Energy Production, and Aging

Mitochondria are central to the aging process through their roles in ATP generation, regulation of reactive oxygen species, apoptosis, and cellular signaling. Ageassociated mitochondrial dysfunction contributes

to fatigue, sarcopenia, insulin resistance, immune dysregulation, and neurodegeneration. Declining mitochondrial efficiency also reduces metabolic flexibility, limiting the body’s ability to adapt to physiological stressors such as illness, fasting, or environmental toxin exposure.

Cellular energy production relies on coordinated activity across several metabolic pathways, including the tricarboxylic acid (TCA) cycle, glycolysis and lactic acid metabolism, and fatty acid oxidation. Disruption in any of these pathways can compromise ATP availability and increase oxidative stress. Urinary metabolites such as citrate, succinate, fumarate, lactate, pyruvate, adipate, and suberate provide clinically meaningful information regarding enzyme activity, cofactor sufficiency, nutrient utilization, and toxin-mediated inhibition of mitochondrial enzymes.

For example, elevations in certain TCA intermediates may suggest enzymatic bottlenecks or exposure to environmental inhibitors, while abnormal fatty acid oxidation markers can reflect impaired metabolic flexibility or increased reliance on ketone metabolism. In anti-aging practice, these findings support individualized interventions aimed at restoring mitochondrial efficiency and improving cellular energy availability.

Detoxiﬁcation Pathways, Oxidative Stress, and Longevity

Throughout the lifespan, individuals accumulate exposure to environmental toxins through air, food, water, and consumer products. These exposures place ongoing demand on hepatic and cellular detoxification systems. Inefficient detoxification contributes to chronic oxidative stress, mitochondrial injury, and systemic inflammation—key drivers of biological aging.

Detoxification occurs primarily through phase I and phase II enzymatic pathways. Phase I reactions, largely mediated by cytochrome P450 enzymes, modify lipophilic compounds, often generating reactive intermediates. Phase II pathways conjugate these intermediates with molecules such as glutathione, sulfate, or glycine, rendering them more water-soluble and facilitating excretion.

Urinary biomarkers provide insight into the functional status of these pathways. Pyroglutamic acid and 2-hydroxybutyric acid are associated with glutathione demand and synthesis, while 8-hydroxy2-deoxyguanosine (8-OHdG) serves as a marker of oxidative DNA damage. Elevated levels of these markers are associated with increased inflammatory burden and impaired cellular repair, both of which are strongly linked to accelerated aging and age-related disease.

The Gut is important for Metabolism and Mental Health

About 100 trillion microbes inhabit the human gut, and they also inhabit other parts of the body such as the throat, upper respiratory tract, and skin. Because of the large number of microbial cells present and their metabolites are absorbed into the blood stream it is important to make sure that their population is managed correctly. Overabundance of pathogenic microbials can cause many different conditions such as problems with mood, cognition, energy, immune systems, and inflammation.

Fungal pathogens cause more than a billion human infections every year and at least 1.6 million deaths per year. There are many different types of fungal species and markers for them can differ. Different fungal species produce Arabitol in the body which is then converted to Arabinose in the body. Arabinose can be present in the urine from dietary sources. Besides identifying general overgrowths, we are very interested in detecting colonizations of many different species of pathogenic mold. Some of the more common types of molds that can colonize in humans are Aspergillus, Fusarium, and penicillium. These molds can release toxins (mycotoxins) which can lead to a whole host of different health problems for the patient. About a third of patients with elevated mycotoxins have overgrowths of these different mold species. Utilizing three different markers that are specific for mold colonization we are helping to individualize care for many different types of ailments.

More common than fungal overgrowths are bacterial overgrowths. Overgrowths of bacteria in the intestines

or overabundance of pathogenic bacteria can lead to many different types of diseases. The toxins that these pathogenic bacteria produce many different effects such as inflammation, lower nutrient absorption, inhibition of neurotransmitter metabolism, and many others.

Neurotransmitter Metabolism and Cognitive Aging

Cognitive decline, mood disturbances, and sleep disorders commonly emerge with advancing age and significantly impact quality of life. Neurotransmitters play essential roles not only in central nervous system signaling but also in peripheral immune and endocrine regulation. Chronic stress, inflammation, and metabolic dysfunction can disrupt neurotransmitter balance, contributing to cognitive and emotional symptoms.

Historically, skepticism existed regarding the relevance of urinary neurotransmitter metabolites due to the presence of the blood–brain barrier. However, growing evidence demonstrates bidirectional transport of neurotransmitters and their metabolites across the barrier, as well as clinically meaningful correlations between urinary measures and central nervous system activity.

Metabolites such as homovanillic acid, vanillylmandelic acid, and 5-hydroxyindoleacetic acid reflect dopaminergic, adrenergic, and serotonergic activity. In the context of anti-aging medicine, assessment of these markers can aid in understanding stress physiology, mood regulation, sleep quality, and cognitive resilience, supporting more personalized interventions.

Measuring Nutrients in the Body can assist Anti-Aging

Bodies use a lot of different molecules to function properly. These molecules include reactants (which help fuel the different reactions) and co-factors (chemicals which are not destroy in the reaction but are important to speed up the reactions). Having the proper amounts of reactants and co-factors is important to maintain a healthy individual. These molecules are either acquired through diet or made from other molecules in the

Metabolic Assessment as a Cornerstone of Anti-Aging Medicine: Clinical Insights from Comprehensive Urinary Biomarker Analysis

body. Monitoring these compounds is helpful when monitoring if changes in diet or supplementation need to occur to help the body.

Clinical Integration in Anti-Aging Practice

The integration of metabolic, detoxification, and neurotransmitter assessment enables clinicians to move beyond symptom-based approaches toward a more personalized model of aging care. By identifying biochemical patterns associated with energy

production, oxidative stress, and neurochemical balance, practitioners can tailor nutritional, lifestyle, and therapeutic strategies to the individual’s biological aging profile.

This systems-based approach aligns closely with the goals of anti-aging medicine, emphasizing prevention, early intervention, and preservation of physiological resilience. Comprehensive metabolic assessment serves as a valuable tool for monitoring progress over time and adjusting interventions as patients age.

Resources

• National Institute on Aging

• Mitochondrial Medicine Society

References:

3. de Lignieres B. Hormone replacement therapy: clinical benefits and side-effects. Maturitas. 1996;23 Suppl:S31-36. doi:10.1016/ s0378-5122(96)90012-2

6. Weiss SR, Ellman H, Dolker M. A randomized controlled trial of four doses of transdermal estradiol for preventing

Author Biography

• Environmental Working Group

• International Society for Nutritional Psychiatry Research

postmenopausal bone loss. Transdermal Estradiol Investigator Group. Obstet Gynecol. 1999;94(3):330-336. doi:10.1016/s00297844(99)00313-0

Matt Pratt-Hyatt, PhD, is a biomedical scientist with over 25 years of experience in metabolomics and personalized medicine, focusing on clinical applications of metabolic biomarkers in longevity-focused care.

Contact: info@kbmodiagnostics.com | 888-525-2312

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NeuroCalm Peptide™ is a unique dual-pathway formula with Lactium® peptide balancing the HPA axis and postbiotic L. gasseri balancing the gut–brain connection. Now your patients can thrive in today's hectic world and achieve 30% salivary cortisol reduction.*1

Supporting Healthy Aging Through Gut–Brain and GABA Pathway Modulation

By: Danielle C . Male, MS | Head Science Writer,

Designs for Health

Stress resilience and restorative sleep are foundational determinants of healthy aging. Ongoing psychological stress and insufficient sleep are associated with cardiometabolic dysfunction, mood disturbance, cognitive decline, and markers of accelerated biological aging. Persistent elevations in cortisol and catecholamines contribute to autonomic imbalance, inflammatory signaling, and metabolic dysregulation over time. While acute stress responses are adaptive, sustained activation erodes physiologic homeostasis and is associated with unhealthy aging.1,2

The gut-brain axis represents a clinically actionable target in this context. This bidirectional network integrates intestinal microbiota activity with central nervous system function through neural, immune, endocrine, and metabolic pathways. Microbial metabolites and immune mediators originating in the gut influence stress responsiveness, sleep architecture, and mood regulation.3 Supporting this axis, alongside central inhibitory signaling, provides a practical strategy to promote adaptive stress responses across the lifespan.

Two ingredients with growing clinical support in this domain are heat-treated Lactobacillus gasseri CP2305 and Lactium®, a milk protein hydrolysate containing the bioactive peptide α-casozepine. These ingredients act on complementary components of stress physiology: gut-derived modulation of the hypothalamic-pituitaryadrenal (HPA) axis and central GABAergic signaling.3-9

Lactobacillus gasseri CP2305: A HeatTreated Para-Psychobiotic

L. gasseri CP2305 is a gram-positive strain originally isolated from the human intestine.10 Although traditionally classified as a probiotic, it has been clinically evaluated in its heat-treated, non-viable form, classifying it as a paraprobiotic.11,12 Biological activity is attributed to structural components rather than colonization.11

Mechanistic research indicates that CP2305 influences the gut-brain axis by modulating intestinal immune signaling, autonomic tone, and HPA axis activity.4,10 Structural components typical of gram-positive organisms may interact with host pattern-recognition receptors, contributing to downstream effects on

immune balance and neurotransmitter pathways relevant to stress physiology.13 CP2305 intake has also been associated with shifts in short-chain fatty acid (SCFA)-producing bacteria, supporting gut-derived signaling relevant to neuroendocrine regulation.14 These characteristics position CP2305 as the first “para-psychobiotic”, according to some literature, with implications for stress adaptation and sleep regulation, two central pillars of healthy aging.4

Stress Resilience in Clinical Trials with L. gasseri CP2305

Multiple randomized, double-blind, placebo-controlled trials have evaluated CP2305 in individuals exposed to psychological stress, including medical students.4,5,14,15

In a 24-week trial of 60 medical students preparing for national board exams, the group that received 10 billion heat-treated CP2305 cells daily showed significantly lower anxiety and sleep disturbance scores than the placebo group, as measured by the Spielberger StateTrait Anxiety Inventory and the Pittsburgh Sleep Quality Index (PSQI).5 Salivary chromogranin A levels also decreased significantly compared to placebo, which is a protein that can serve as a marker for stress, as its secretion may indicate activated sympatho-adrenal activity.5,16 Microbiome analysis showed significant attenuation of stress-related reductions in Bifidobacterium spp. and increases in Streptococcus spp. among those assigned to CP2305.5 Additional clinical studies have shown that individuals who received CP2305 demonstrated favorable shifts in gut microbial composition, including increased Bifidobacterium abundance, along with improvements in Bristol Stool Scale scores, stool frequency, odor scores, and reductions in fecal p-cresol concentrations – all changes consistent with improved gut–brain signaling relevant to healthy aging.11,12

In another 12-week study of 69 medical students, participants who received CP2305 exhibited improved subjective and electroencephalographic sleep parameters, reduced salivary cortisol, enhanced

parasympathetic nerve activity, and stabilization of bowel habits compared with placebo. Alterations in stress-responsive microRNA expression were also mitigated in the CP2305 group.4 A four-week crossover study involving 24 male medical students in a cadaver dissection course found that during the CP2305 intake, participants reported significantly improved anxiety, mood, and sleep scores, along with approximately 30% lower salivary cortisol concentrations than during the placebo phases. Reduced Enterobacteriaceae growth and normalization of stress-suppressed eIF2-related gene expression were also observed during CP2305 administration.15

Beyond student populations, eighty women aged 40 to 60 years with mild menopausal symptoms who were assigned to 10 billion heat-treated CP2305 cells daily for six consecutive menstrual cycles demonstrated significant improvements in the total, vasomotor, and psychological domains of the Simplified Menopausal Index (SMI) compared with placebo.10 Total, somatic, and vasomotor scores on the Greene Climacteric Scale (GCS) improved in the CP2305 group, while psychological and sexual subscales did not differ significantly between groups. In total, 75% of women receiving CP2305 reported overall symptom relief, compared with 55% in the placebo group, suggesting a positive trend (p = 0.0594).10

Across these trials, modulation of gut-derived signaling and autonomic balance was consistently associated with improved stress tolerance and sleep-related outcomes, two pivotal foundations for healthy aging.4,5,10-12,14,15

Lactium® (α-Casozepine): Central GABAA Receptor Support

Lactium® is a milk protein hydrolysate containing α-casozepine, a decapeptide derived from bovine αS1-casein. Preclinical investigations indicate that α-casozepine binds to the benzodiazepine site of central GABAA receptors (key regulators of stress physiology), helping to dampen excitatory signals from

stress-responsive neurons.6 This interaction has been associated with anxiolytic-like effects in animal models and demonstrated favorable tolerability.6-9

Clinical Stress and Sleep Outcomes with Lactium® (α-Casozepine)

Human trials have evaluated Lactium® in populations experiencing psychological stress. In a multinational study conducted in France (n = 122), the United States (n = 111), and China (n = 105), participants who received 300 mg/day of Lactium® for one month demonstrated significant improvements from baseline in perceived stress and sleep quality on validated questionnaires, including the Perceived Stress Scale-10 and PSQI.16 Satisfaction rates ranged from 70% to nearly 90% across regions.17

In a crossover trial, 63 women with stress-related symptoms consumed 150 mg/day of Lactium® for 30 days. By day 15, the women receiving Lactium® reported significant improvements in digestive and cardiovascular symptoms. By day 30 in the Lactium® group, the women with high baseline symptom severity showed statistically significant improvements in eight domains, including emotional problems, intellectual troubles, and social troubles.18

Across randomized sleep-focused trials in adults with sleep disturbances, participants administered 150 mg/day to 600 mg/day demonstrated significant improvements in PSQI scores, sleep latency, actigraphybased sleep measures, and Global Sleep Disorders Scores compared with placebo.19-21 These findings include individuals with chronic insomnia, where reductions in sleep onset latency and overall sleep disturbance were observed in the Lactium® groups

relative to placebo.19 By engaging central GABAA receptor pathways involved in stress and sleep regulation, α-casozepine provides a complementary mechanism to gut-directed strategies.6-9

Summary: Integrating Gut-Brain and GABA Pathways in Healthy Aging Care

Persistent stress and sleep disruption contribute to inflammatory activation, autonomic imbalance, metabolic dysregulation, and mood disturbance, which are all features commonly observed in unhealthy aging.1,2 Supporting adaptive stress responses and restorative sleep is central to promoting healthspan for health-care practitioners.

Heat-treated L. gasseri CP2305 and Lactium® influence complementary dimensions of this physiology. Across controlled trials, the group receiving CP2305 demonstrated modulation of microbiota composition, parasympathetic tone, cortisol balance, and stressrelated symptom scores.4,5,10-12,14,15 Lactium®, through α-casozepine, has been associated with improvements in perceived stress and multiple measures of sleep quality consistent with GABAA receptor engagement.6,17-21

For integrative practitioners, these findings demonstrate the value of addressing both peripheral gut-derived signaling and central inhibitory neurotransmission when designing protocols to reinforce resilience to psychological stress. Because stress regulation and sleep quality remain modifiable throughout the lifespan, incorporating targeted gut0brain and GABA-supportive interventions may offer meaningful support for patients seeking to preserve cognitive clarity, emotional balance, and metabolic stability as they age.

Author Biography

Danielle C . Male has an M.S. in Nutrition and is a board-Certified Nutrition Specialist® and a Licensed Dietitian Nutritionist. She is the Head Science Writer for Designs for Health and has taught college-level nutrition. dmale@designsforhealth.com

Designs for Health (DFH) is the #1 practitioner brand recommended by functional medicine professionals

References:

1. Ravyts SG, Dzierzewski JM. Sleep and healthy aging: a systematic review and path forward. Clin Gerontol. 2024;47(3):367-379. doi:10 .1080/07317115.2022.2064789

2. Hansen JL, Carroll JE, Seeman TE, Cole SW, Rentscher KE. Lifetime chronic stress exposures, stress hormones, and biological aging: results from the Midlife in the United States (MIDUS) Study. Brain Behav Immun. 2025;123:1159-1168. doi:10.1016/j.bbi.2024.10.022

3. Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota’s effect on mental health: the gut–brain axis. Clin Pract 2017;7(4):987. doi:10.4081/cp.2017.987

4. Nishida K, Sawada D, Kuwano Y, et al. Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students. J Funct Foods. 2017;36:112-121. doi:10.1016/j.jff.2017.06.031

5. Nishida K, Sawada D, Kuwano Y, Tanaka H, Rokutan K. Health benefits of Lactobacillus gasseri CP2305 tablets in young adults exposed to chronic stress: a randomized, double-blind, placebocontrolled study. Nutrients. 2019;11(8):1859. doi:10.3390/ nu11081859

6. Benoit S, Chaumontet C, Violle N, et al. The anxiolytic-like properties of a tryptic hydrolysate of bovine αs1 casein containing α-casozepine rely on GABAA receptor benzodiazepine binding sites but not the vagus nerve. Nutrients. 2022;14(11):2212. doi:10.3390/nu14112212

7. Violle N, Messaoudi M, Lefranc-Millot C, et al. Ethological comparison of the effects of a bovine alpha s1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety. Pharmacol Biochem Behav. 2006;84(3):517-523. doi:10.1016/j.pbb.2006.06.017

8. Miclo L, Perrin E, Driou A, et al. Characterization of alphacasozepine, a tryptic peptide from bovine alpha(s1)-casein with benzodiazepine-like activity. FASEB J. 2001;15(10):1780-1782. doi:10.1096/fj.00-0685fje

9. Messaoudi M, Lalonde R, Schroeder H, Desor D. Anxiolytic-like effects and safety profile of a tryptic hydrolysate from bovine alpha s1-casein in rats. Fundam Clin Pharmacol. 2009;23(3):323330. doi:10.1111/j.1472-8206.2009.00672.x

10. Sawada D, Sugawara T, Hirota T, Nakamura Y. Effects of Lactobacillus gasseri CP2305 on mild menopausal symptoms in middle-aged women. Nutrients. 2022;14(9):1695. doi:10.3390/ nu14091695

11. Sawada D, Sugawara T, Ishida Y, et al. Effect of continuous ingestion of a beverage prepared with Lactobacillus gasseri

who know DFH.* This dedication to quality and passion for the industry, along with the DFH team who share these values, is why DFH customers have remained loyal to the brand for 37 years.

*U.S.A. Functional Medicine MDs, DOs, NDs, DCs, and Nutrition Professionals surveyed in 2025 for Designs for Health.

CP2305 inactivated by heat treatment on the regulation of intestinal function. Food Res Int. 2016;79:33-39. doi:10.1016/j. foodres.2015.11.032

12. Sugawara T, Sawada D, Ishida Y, et al. Regulatory effect of paraprobiotic Lactobacillus gasseri CP2305 on gut environment and function. Microb Ecol Health Dis. 2016;27:10.30259. doi:10.3402/mehd.v27.30259

13. Teame T, Wang A, Xie M, et al. Paraprobiotics and postbiotics of probiotic Lactobacilli, their positive effects on the host and action mechanisms: a review. Front Nutr. 2020;7:570344. doi:10.3389/ fnut.2020.570344

14. Sawada D, Kuwano Y, Tanaka H, et al. Daily intake of Lactobacillus gasseri CP2305 relieves fatigue and stress-related symptoms in male university Ekiden runners: a double-blind, randomized, and placebo-controlled clinical trial. J Funct Foods. 2019;57:465-476. doi:10.1016/j.jff.2019.04.022

15. Sawada D, Kawai T, Nishida K, Kuwano Y, Fujiwara S, Rokutan K. Daily intake of Lactobacillus gasseri CP2305 improves mental, physical, and sleep quality among Japanese medical students enrolled in a cadaver dissection course. J Funct Foods. 2017;31:188-197. doi:10.1016/j.jff.2017.01.042

16. Kanamaru Y, Kikukawa A, Shimamura K. Salivary chromogranin-A as a marker of psychological stress during a cognitive test battery in humans. Stress. 2006;9(3):127-131. doi:10.1080/14769670600909594

17. Moro J, Boulier A, Cremonese V. Evaluation of perceived stress and sleep improvement with the dairy bioactive Lactium®. Curr Dev Nutr. 2022;6:318. doi:10.1093/cdn/nzac053.059

18. Kim JH, Desor D, Kim YT, et al. Efficacy of alphas1-casein hydrolysate on stress-related symptoms in women. Eur J Clin Nutr. 2007;61(4):536-541. doi:10.1038/sj.ejcn.1602553

19. Chang CM, Tsai IJ, Yang CC, Liu WC, Yang CP. The impact of alpha-s1 casein hydrolysate on chronic insomnia: a randomized, double-blind controlled trial. Clin Nutr. 2024;43(12):275-284. doi:10.1016/j.clnu.2024.10.039

20. de Saint-Hilaire Z, Messaoudi M, Desor D, Kobayashi T. Effects of a bovine alpha s1-casein tryptic hydrolysate (CTH) on sleep disorder in Japanese general population. Open Sleep J. 2009;2:26-32. doi:10. 2174/1874620900902010026

21. Kim HJ, Kim J, Lee S, et al. A double-blind, randomized, placebocontrolled crossover clinical study of the effects of alpha-s1 casein hydrolysate on sleep disturbance. Nutrients. 2019;11(7):1466. doi:10.3390/nu11071466

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• Seeks to reduce their melatonin intake

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Promote restorative deep and REM sleep.*

How It Works:

MODULATING THE OREXIN PATHWAY: A Melatonin-Free, Peptide-Based Strategy for Restorative Sleep

By:

Biotics Research Team

Sleep disturbance remains a significant clinical challenge, with an estimated 30–40% of adults reporting difficulty falling asleep, maintaining sleep, or waking unrefreshed.

[1] Insufficient or poor-quality sleep is associated with metabolic dysfunction, mood dysregulation, impaired cognitive performance, cardiovascular strain, and reduced daytime resilience. Given the individualized nature of sleep patterns and the limitations of sedative or hormone-based interventions, clinicians are increasingly seeking physiologic strategies that work with—rather than override—the body’s regulatory systems.

An emerging target is the orexin (hypocretin) pathway, a central regulator of wakefulness, arousal, and circadian cortisol rhythms. Orexin signaling promotes alertness by stimulating adrenal cortisol release through the HPA axis. Under healthy physiology, orexin activity declines at night, allowing cortisol to fall and sleep onset to occur. However, stress, circadian disruption, and aging can sustain orexin activity into the evening, contributing to elevated nighttime cortisol and subsequent difficulty initiating and sustaining sleep. [2,3]

Advances in peptidomics have identified plantderived bioactive peptides that modulate peripheral orexin-related signaling. These peptides—featured in SleepTides™—were discovered using AI-driven peptide mapping and molecular docking techniques and have been shown in preclinical models to remain viable after digestion while influencing adrenal cortisol release through peripheral orexin receptors.[4,5] Importantly, these peptides provide a melatonin-free, non-sedating option for patients who are sensitive to melatonin or prefer a physiological approach to sleep regulation.

A randomized, placebo-controlled clinical trial evaluated nightly supplementation of 250 mg of these plant peptides in adults with mild to moderate sleep impairment. Participants experienced meaningful improvements in validated subjective measures, including a 3% increase in ease of getting to sleep (GTS) and an 12% increase in perceived quality of sleep (QOS) on the Leeds Sleep Evaluation Questionnaire (LSEQ).[4] Upward trends in ease of awakening and behavior upon waking suggest support for next-day alertness and reduced morning grogginess.

Modulating the Orexin Pathway: A Melatonin-Free, Peptide-Based Strategy for Restorative Sleep

Mood outcomes also improved. On the Profile of Mood States (POMS), participants receiving the peptides demonstrated improved total mood, whereas the placebo group worsened slightly. Significant improvement in the anger subscale further highlights the relationship between sleep continuity and emotional regulation.[4]

Objective biometric data collected via Oura Ring supported these findings. Supplementation was associated with a 13-minute increase in deep sleep,

a 12-minute increase in REM sleep, an average 38-minute increase in total sleep time, and a 32% increase in heart rate variability (HRV)—a key marker of autonomic recovery.[4]

With clinical benefits observed at 250 mg nightly taken 30-60 minutes prior to bedtime, SleepTides™ offers practitioners a physiologic, melatonin-free option for supporting patients experiencing stress-related or cortisol-mediated sleep disturbances.

References

1. Nuritas Research Group. Randomized, Single-Blind, PlaceboControlled Study Evaluating Plant-Derived Peptides for Sleep Quality and Mood. 2024.

2. Mohan N., et al. Circadian Regulation of Cortisol and Its Impact on Sleep Architecture. 2023.

3. Franklyn-Miller A., et al. Stress-Induced Elevations of Evening Cortisol and Their Effects on Sleep Quality. 2023.

4. Nuritas Research Group. Pilot Clinical Evaluation of Plant Peptides: LSEQ, POMS, and Oura Ring Outcomes. 2024.

5. Nuritas Scientific Team. In Vitro Assessment of Plant Peptides on Orexin Receptors and Cortisol Signaling. 2023.

6. Peptidomics & AI Discovery Team. Identification and Characterization of Plant-Based Bioactive Peptides for Sleep Support. 2023.

• Evidence-Based Formulations

• Uncompromising Raw Materials

• Patients Get Better, Faster

For more than 35 years, Ortho Molecular Products has partnered with health care professionals to provide the very best supplements with an unwavering commitment to e cacy.

PRODUCT ANNOUNCEMENTS

Biobox™ At-home Blood TestingAccess Labs™

Booth #409

Access Labs

Ph: (866) 720-8386 | www.accessmedlab.com

Demand for convenience has never been higher. Access Labs’ anytime, anywhere blood collection kit makes testing simple for even the busiest patients. Providers can choose from 10+ functional health panels, shipped via 2-day air directly to the patient’s home, with results available within 24–48 hours after the sample arrives at the lab.

Visit our booth to learn more about Access Labs’ at-home solutions for blood, saliva, and urine testing.

Tirzepatide Nasal Spray

Booth #701

Central Drugs Compounding Pharmacy

Ph: (562) 691-6754 | www.centraldrugsrx.com

Intranasal Tirzepatide: Advanced Science. Smarter Delivery. Tirzepatide supports blood sugar balance and appetite control by targeting GLP-1 and GIP pathways, but what truly sets this apart is the delivery system. Why Intranasal?

• Painless, needle-free alternative designed to improve comfort and compliance

• Patented sub-nano technology, used to deliver tripeptides like glutathione and GHK-Cu, to enhance abasorption through the nasal vasculature

• Bypasses first-pass liver metabolism to help optimize bioavailability

• No injections and no holding under the tongue

• Convenient, easy administration that supports patient consistency

Powerful metabolic support, delivered in a way patients prefer.

SleepTides™

Booth #107

Biotics Research

Ph: (800) 231-5777 | www.bioticsresearch.com

SleepTides™ features bioactive plant peptides derived from brown rice, developed using AI-driven peptidomics technology to support all phases of the sleep cycle. This advanced formula helps regulate cortisol levels and promotes the body’s natural rhythm of deep, restorative “sleep waves.” Clinical research shows improvements in deep sleep, REM sleep, and overall sleep duration. SleepTides™ is non-habit forming and welltolerated.

NeuroCalm Peptide™

Booth #601

Designs for Health

Ph: (860) 623-6314 | www.designsforhealth.com

Helps reduce the effects of occasional anxiety*

NeuroCalm Peptide™ promotes gut-brain harmony to support feelings of calm, stress resilience, and emotional well-being.*

This once-daily capsule provides a unified approach to supporting balance along the gut-brain axis.* It combines two clinically studied ingredients: Lactium® and heattreated Lactobacillus gasseri CP2305.

- Daily support for mood and stress resilience*

- Promotes a healthy gut-brain connection*

- Helps reduce the effects of occasional anxiety and perceived stress*

- Supports balanced cortisol metabolism (the “stress hormone”)*

- May help reduce occasional stress-related digestive troubles*

- Promotes healthy, calming sleep*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

EvexiTHROID

Booth #401

EVEXIAS Health Solutions

Ph: (817) 203-8249 | www.evexias.com

EvexiTHROID™ is a precision-formulated desiccated thyroid therapy designed for patients who remain symptomatic on T4-only treatment. Delivering both T4 and bioavailable T3 in a physiologic ratio, it supports cellular metabolism, symptom improvement, and individualized dosing based on clinical response. By helping clinicians address conversion challenges and optimize thyroid signaling, EvexiTHROID offers a longawaited solution for complex hypothyroid cases and more consistent patient outcomes.

AI Clinical Assistant

Booth #627

Heads Up

Ph: (602) 671-3074 | www.headsup.health

Heads Up AI Clinical Assistant. Your patients are more than their last lab result. Unify data from wearables, labs, EHRs, and health apps into a single intelligent view — giving your team the full picture in real time. Built for longevity and precision medicine, it delivers Clinical Decision Support aligned with your protocols, pre-visit summaries that surface what’s changed, and trend insights that amplify clinical judgment — without alert fatigue. Treat the whole person. Scale personalized care.

Women’s Health +

Booth #801

Genova Diagnostics

Ph: (800)522-4762 | www.gdx.net/a4m

Assess Women’s Health with One Powerful New Tool! Hormones are a key influence on mood, energy, and cycles, but they don’t act alone. Nutritional needs shift throughout life stages, genetics determine unique predispositions, and how the body metabolizes hormones can determine disease risk.Genova’s Women’s Health+ profile assesses hormones, nutrition, and genomics to reveal clear clinical priorities and practical next steps, so you can move from complex symptoms to a confident, individualized plan.

FRA 510S

Booth #207

InBody

Ph: (323) 932-6503 | www.inbody.com

InBody introduces the FRA 510S, a new fall risk assessment system built to measure what traditional screenings miss. Designed for clinical, rehabilitation, senior care, fitness, and performance environments, the FRA 510S evaluates balance control, reaction time, and lower-body strength in one integrated solution. As part of the InBody ecosystem, it connects body composition with real-world functional performance, helping professionals identify risk sooner and guide meaningful intervention.

Glyphosate Test

Booth #426

KBMO Diagnostics

Ph: (617) 933-8130 | www.kbmodiagnostics.com

At KBMO Diagnostics, our Glyphosate Exposure Test offers a simple and accurate way to measure glyphosate burden. We have improved upon old methodology to remove interferences in order to improve sensitivity. Glyphosate may not cause immediate symptoms; however, long-term exposure can have serious effects on the gut, hormones, immunity, and overall health. This test can easily be pair with our Organic Acids Test, the Metabolic Insights Profile (MIP).

Biotin 10mg/mL

Booth #301

Olympia Pharmaceuticals

Ph: (407) 673-2222 | olympiapharmacy.com

Olympia’s 10mg/mL formula of Biotin is an all-new way to experience the classic vitamin. Formulated for IV infusion and IM injection, this product is popular in regimens geared toward hair, skin, and nail health.

With over twenty times as much biotin in it as Olympia’s original 0.5mg/mL formula, options for patient-specific dosing have increased exponentially. This Longevity staple is available now!

Gut-Brain Reset

Booth #417

Microbiome Labs

Ph: (904) 940-2208 | microbiomelabs.com

Gut-Brain Reset is a dual-action probiotic combination designed to support both digestive comfort and mood self-regulation. This unique, holistic solution targets the gut-brain axis and is clinically demonstrated to support the relief of occasional gastrointestinal (GI) discomfort and its associated psychological stress. Powered by two innovative probiotic strains, Gut-Brain Reset provides around-the-clock digestive maintenance, supporting optimal gut health and overall well-being.

Calocurb® CLINICAL Starter Pack

Booth #221

Ortho Molecular Products

Ph: (800) 332-2351 | www.orthomolecularproducts.com

Fast-acting and plant-based, Calocurb® CLINICAL offers a targeted, science-driven approach to supporting healthy weight management. It features Amarasate®, a clinically studied extract of New Zealand bitter hops, delivered in a delayed-release capsule designed to reach the small intestine where it activates bitter taste receptors and triggers the release of key satiety hormones to significantly reduce hunger, cravings and caloric intake. The formula starts working in one hour with results lasting up to six hours.

Custom Hyperbaric Chambers

Booth #80

OxyHealth

Ph: (562) 906-8888 | www.oxyhealth.com

Now available with premium outer jackets in grey, black, or navy. Our hyperbaric chambers can be tailored to complement your clinic’s aesthetic with customizable exterior color and logo placement to reflect your practice identity while maintaining the highest standards of clinical excellence.

Transfer Factor Rapid Response™

Booth #527

Researched Nutritionals®

Ph: (805) 693-1802 | www.researchednutritionals.com

Transfer Factor Rapid Response™ has arrived! A new era of advanced, multi-mechanism immune support.

• Features two specialized immune-supporting blends targeting innate and adaptive immunity

• Supports healthy immune modulation for balanced immune function

• Promotes gut lining resilience, a key component of overall immune health

• Designed to deliver fast-acting, comprehensive immune support

• Formulated to support and empower the body’s natural defenses

Liposomal Thymulin Zinc Complex + Liposomal Epitalon

Booth #807

Quicksilver Scientific

Ph: (303) 531-0861 | www.quicksilverscientific.com

Liposomal Epitalon and Thymulin Zinc Complex work synergistically to support cellular longevity, circadian rhythm, and immune resilience. Modeled after key regulatory peptides, Epitalon supports telomere integrity, healthy cellular turnover, antioxidant defenses, and balanced melatonin production, while Thymulin Zinc Complex promotes thymic renewal, T-cell maturation, and optimal immune signaling. Delivered in highly absorbable liposomal formats, this advanced peptide pairing helps maintain neuroendocrine-immune balance, energy, restorative sleep, and long-term vitality as part of a comprehensive healthy aging strategy.

FadeRx Cream

Booth #101

Rush Pharmacy

Ph: (407) 205-7336 | www.rushpharmacy.com

A pharmaceutical-grade silicone gel designed to support skin recovery and improve the appearance of scars, stretch marks, and other skin irregularities. This lightweight, anhydrous formula forms a breathable barrier that helps maintain hydration, soften texture, and promote smoother, more even-looking skin. Suitable for all skin types, it integrates easily into daily skincare routines for consistent, visible results.

Creatine Powerline

Booth #501

Strive Compounding Pharmacy

Ph: (480) 626-4366 | shop.strivepharmacy.com/products/ creatine-powerline

Strives pharmacist formulated Creatine Powerline delivers a cutting-edge creatine monohydrate formula enhanced with a magnesium hydrogel matrix for superior absorption and digestive comfort. This innovation reduces breakdown in the stomach and supports hydration balance. Perfect for anyone seeking to support lean muscle, boost cellular energy, and promote cognitive performance.

Potential Benefits:

- Supports lean muscle strength and growth when combined with resistance training

- Boosts ATP production for energy and recovery

- May enhance cognitive performance

- Contributes to healthy aging

Foundation Zoomer

Booth #813

Vibrant Wellness

Ph: (866) 364-0963 | vibrant-wellness.com

The Foundation Zoomer provides a system-level baseline view of whole-body health in a single, integrated blood test. It brings together metabolic, cardiovascular, hormonal, immune, nutrient, and organ-function markers to help clinicians understand how core physiological systems interact and where imbalance may be developing. Designed as a clinical starting point, Foundational Zoomer supports efficient triage, clearer test selection, and more confident care planning for patients with complex or nonspecific symptoms.

TA-65MD® 250 Unit Capsules (30 count)

Booth #113

T .A . Sciences

Ph: (888) 360-8886 | www.tasciences.com

Introducing TA-65MD® 250 Unit Capsules (30 count) – an innovative mid-range option for clinicians focused on advanced longevity therapies.

Each capsule delivers 250 units of TA-65®, a rigorously validated, plant-derived compound that supports telomere integrity and combats cellular aging. Offered as a 30-day supply, this formulation enables tailored dosing under the guidance of a certified TA-65® physician, ensuring optimized therapeutic outcomes. Elevate your clinical practice with this potent, evidence-based solution for anti-aging and cellular rejuvenation today.

TESTING UPDATE

Booth #607

ZRT LABORATORY

Ph: (866) 600-1636 | ZRTLAB.COM

ZRT Lab now offers more choices for testing salivary steroid hormones-choose from 3, 5, 7, 15, or 23 hormone profiles. Salivary 4x and 6x (CAR) cortisol assays are now performed by Roche ECLIA allowing for faster turnaround. Expanded thyroid, fertility, and cardiometabolic panels are now available using Dried Blood Spots (DBS) tested by Roche ECLIA. Blood steroid hormone profiles using DBS, an excellent and more convenient patient-friendly alternative to serum, are now available for testing by LC-MS/MS with expanded panels available for research.

EXHIBITOR INDEX

Introducing our new Rapid Dissolve Tablet

Customized Compounded Solutions for Precision Therapy

Why Rapid Dissolve Tablets?

• Fast Absorption

No Water Required

• Enhanced Patient Compliance

Precision Compounding

• Flexible Dosing Strategies

Available Actives for RDT

• Sildenafil

Tadalafil

• Vardenafil

Peptides

• Oxytocin

NAD+

• Custom blends available

EXHIBITOR FLOORPLAN

EXHIBITOR LISTINGS

VIRUN

3X4 Genetics

Booth #11104

Booth #626

VIRUN

1750 N. 8th St.

215 S Highway 101., Ste 100 Bellevue, California, 92075

Colton, California, 92324

United States

Ph: (425) 818-5333

Ph: (909) 618-3267

Email: info@3x4genetics.com

Email: nickols.huang@virun.com

www .3x4genetics .com

www .virun .com

3X4 Genetics is a genetics-based health technology company that combines advanced genetic testing, nutrigenomic education, and a global network of accredited practitioners to help people make sound, daily choices to live longer, healthier, and better lives. We’re transforming people’s lives by giving them data-driven, DNAbased recommendations for fitness, food, supplements, sleep, stress management and more. Our mission is to bring the incredible power of genetic testing to the world.

Virun is an established cGMP-certified liquid dietary supplement manufacturer headquartered in Southern California, with over 25 years of industry expertise. Specialized in turnkey, custom private-label liquid supplement manufacturing—offering everything from formulation to bottling and pouching—all under one roof. To better serve international clients, Virun also provides manufacturing capabilities for the European market through our facility in Dublin, Ireland.

Acella Pharmaceuticals

Booth #1030

1880 McFarland Pkwy., Ste 100

Alpharetta, Georgia, 30004

United States

Ph: (770) 815-6721

Email: swatts@avionrx.com

acellapharma .com

Acella Pharmaceuticals, LLC is a specialty pharmaceutical company committed to innovating the healthcare field by bringing quality and affordable products to our customers and patients.

VIRUN

A4M

Access Medical Labs

Booth #11104

Booth #70

VIRUN

1801 N Military Trail., Ste 110 Boca Raton, Florida, 33431

Booth #409

5151 Corporate Way

Jupiter, Florida, 33458

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (561) 997-0112

United States

Email: info@a4m.com

Ph: (909) 618-3267

Ph: (866) 720-8386

Email: info@accessmedlab.com

Email: nickols.huang@virun.com

www .a4m .com

www .virun .com

www .accessmedlab .com

Driven by a visionary mission to revolutionize healthcare, The American Academy of AntiAging Medicine (A4M) is the world’s leading provider of advanced medical education in functional, preventive, and longevity medicine. Through its diverse array of innovative learning opportunities, A4M equips forward-thinking practitioners with the expertise and tools to deliver personalized, wholeperson care that optimizes health, vitality, and resilience at every stage of life.

Access delivers advanced diagnostics built for every practice model. Whether you operate a solo practice, telehealth platform, or multi-location clinic, our lab aligns effortlessly with your workflow. Analyze 1,000+ biomarkers across blood, saliva, and urine—from advanced hormones, and toxic and nutritional metals to food sensitivity testing and more—all backed by next-day results and white-glove support. Plus, you’ll enjoy complimentary draw supplies, EMR integration support, and unlimited custom panels!

AexoVitality

Booth #237

10350 Highway 242., Ste 200

Conroe, Texas, 77385

United States

Ph: (856) 373-0971

Email: info@skinsageadvisors.com

www .skinsageadvisors .com

SkinCare Consulting and Biotech distribution company marketing high performance, ethically sourced human exosomes.

Agentis Air LLC

Booth #932

7524 Standish Place., Ste 130

Rockville, Maryland, 20855

United States

Ph: (315) 345-4720

Email: Contact@AgentisAir.com

BrioAirPurifier .com

The Brio 650 by Agentis Air is a next-generation air purifier designed for modern homes and offices. Powered by patented APART™ technology, Brio captures significantly more particulate matter over time without clogging like traditional HEPA systems. With a one-year filter life, zero ozone, ASHRAE 241 compliance for pathogen removal, and exceptionally quiet performance, Brio 650 delivers continuous, high-performance air purification for healthier everyday living.

Simple. Smarter. Faster.

VIRUN

Aligned Modern Health

Booth

#843

Booth #11104

4555 N Lincoln Avenue

VIRUN

Chicago, Illinois, 60625

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (773) 598-4387

United States

Email: info@alignedmodernhealth.com

Ph: (909) 618-3267

alignedmodernhealth .com

Email: nickols.huang@virun.com

www .virun .com

Aligned Modern Health is changing the face of healthcare and building the leading national brand in holistic medicine. Our unique, multidisciplinary model offers patients evidence-based solutions to a host of health challenges including BHRT/hormone issues, thyroid, autoimmunity, stress, GI distress, metabolic disorders, infertility, musculoskeletal pain, and more. We pride ourselves on outstanding clinical outcomes and a five-star patient experience. We have 16 clinics across Chicago, and we offer telehealth services for Functional Medicine and BHRT across 18 states and growing!

#900

5401 Hangar Ct.

VIRUN

Tampa, Florida, 33634

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (800) 995-4363

United States

Email: emarketing@anazaohealth.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

anazaohealth .com

www .virun .com

AnazaoHealth is a specialty compounding pharmacy focusing on Wellness and Pain Management. We have a 30,000-square-foot 503B FDA-Registered Outsourcing Facility in Las Vegas and a 54,000-square-foot traditional 503A compounding pharmacy in Tampa. Both facilities have the appropriate licensure to conduct business in most states, the District of Columbia, and selected U.S. territories. AnazaoHealth compounds preparations for Age Management, Weight Management, IV Therapy, Sexual Health, Vitamin Injections, Hormone Replacement, Hair Care Solutions, Aesthetics and more.

VIRUN

Alletess Medical Laboratory

Booth

#1013

Booth #11104

14 Howard Street

VIRUN

Rockland, Massachusetts, 2370

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (800) 225-5404 x312

Ph: (909) 618-3267

Email: alletess@foodallergy.com

foodallergy .com

Email: nickols.huang@virun.com www .virun .com

Founded in 1980, Alletess Medical Laboratory is a leader in allergy and immunology testing, serving clinicians worldwide. With expert professionals, advanced technology, and customized Wellness Programs, we provide comprehensive laboratory solutions tailored to each client’s needs. We recognize the critical role test results play in patient care and deliver accurate, actionable insights—because at Alletess, we believe the test result is just the beginning of the journey toward better outcomes and healthier futures.

Alpha BioMed Labs

VIRUN

Booth #11104

VIRUN

#742

200 Spectrum Center Dr. Irvine, California, 92618

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (888) 890-8143

Email: support@alphabiomedlabs.com

Ph: (909) 618-3267

www .alphabiomedlabs .com

Email: nickols.huang@virun.com www .virun .com

At Alpha BioMed Labs, we manufacture and supply research-grade peptides designed for laboratory and institutional studies, ensuring analytical consistency and verified purity for controlled applications.

VIRUN

Ancient Nutrition

Booth

#135

Booth #11104

2000 Mallory Ln., Ste 130-137

Franklin, Tennessee, 37067

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (920) 901-6148

Email: lea.jacobs@ancientnutrition.com

Ph: (909) 618-3267

ancientnutrition .com

Email: nickols.huang@virun.com

www .virun .com

At Ancient Nutrition, we help people take charge of their health with history’s most powerful ingredients. By uniting ancient wisdom with modern science, we create products that deliver real results while supporting regenerative practices that restore soil, sequester carbon, and strengthen our ecosystems.

VIRUN

Anderson Longevity Clinic

Booth

VIRUN

#741

#11104

13500 Sutton Park Dr., Ste 504 Jacksonville, Florida, 32224

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (904) 874-5774

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: info@andersonlongevityclinic.com alcfranchise .com

www .virun .com

Anderson Longevity Clinic empowers medical providers to transform lives through premium longevity care while building sustainable wealth and independence. Our proven, turnkey franchise model combines clinical excellence, operational support, and strategic growth tools to help providers deliver advanced wellness services with confidence. By joining our network, providers gain the training, systems, and resources needed to scale a high-impact clinic—creating financial freedom, professional autonomy, and better health outcomes for their communities.

Booth

VIRUN

Booth #11104

VIRUN

Argentyn 23

Booth #122

Booth #11104

7504 Pennsylvania Ave

VIRUN

Sarasota, Florida, 34243

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (941) 702-6100

United States

Ph: (909) 618-3267

Email: orders@sovereignnaturals.com

www .argentyn23 .com

Email: nickols.huang@virun.com

www .virun .com

With the help of a team of highly trained scientists and engineers. Argentyn 23, Sovereign Copper & Sovereign Copper Pro, operates a state-of-theart, NSF Good Manufacturing Practice (GMP)certified lab with the most advanced instruments in the industry. From rigorous testing to global certifications, every step ensures confidence in what you put in your body. Because when it comes to your health, we are redefining standards so that you can have the utmost confidence to RULE YOUR HEALTH™.

Big Bold Health

115 Hall Brothers Loop

Bainbridge Island, Washington, 98110

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (253) 208-4339

United States

Ph: (909) 618-3267

Email: kellybland@bigboldhealth.com

Email: nickols.huang@virun.com

bigboldhealth .com

www .virun .com

Founded by Dr. Jeff Bland, Big Bold Health is on a mission to rebuild health at the root— starting with how our food is grown and how our nutrients are sourced. We create science-backed superfoods and targeted nutrition formulas that help people thrive today while protecting the ecosystems that sustain us tomorrow. At Big Bold Health, we believe longevity is built through daily renewal—of our bodies, our communities, and the planet we depend on.

VIRUN

BellaVita Clinics

Booth #11104

Booth #713

VIRUN

1750 N. 8th St.

72650 Fred Waring Drive., Ste 206 Palm Desert, California, 92260

United States

Colton, California, 92324

United States

Ph: (877) 707-0747

Email: info@bellavitaclinics.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

bellavitaclinics .com

www .virun .com

BellaVita is a comprehensive healthcare partner helping providers build full-spectrum practices that go beyond hormone replacement. By integrating bioidentical hormone therapy (BHRT) with advanced biologics, regenerative medicine, functional labs, and AI-driven dosing technology, BellaVita equips clinics with the products, training, and systems needed to deliver personalized, high-impact patient care; from restored energy and hormonal balance to long-term wholebody wellness.

Bioscope AI

VIRUN

Booth

#735

Booth #11104

880 Monon Green Blvd.

VIRUN

Carmel, Indiana, 46032

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (317) 625-2579

Ph: (909) 618-3267

Email: ellie.pittman@bioscope.ai bioscope .ai

Email: nickols.huang@virun.com www .virun .com

Bioscope.ai is a precision medicine platform designed for concierge and longevityfocused practices. We integrate genomics, microbiome data, labs, and EMR records into a single AI-powered dashboard. The platform eliminates manual chart review and fragmented data interpretation, helping physicians identify root causes faster, personalize treatment plans with precision, and save significant time while delivering better patient outcomes.

BHI Therapeutic Sciences

VIRUN

Booth #537

Booth #11104

214 State Street, Ste 101

VIRUN

1750 N. 8th St.

Hackensack, New Jersey, 7601

Colton, California, 92324

United States

Ph: (212) 206-7073

Email: info@bluehorizoninternational.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

bluehorizoninternational .com

www .virun .com

BHI Therapeutic Sciences, Inc. (BHITS) is a regenerative medicine company. BHITS is pioneering ethical, innovative, effective, and safe regenerative therapies with cultured human Wharton’s jellyderived mesenchymal stem cells, exosomes, and immunotherapy.

• Where cutting-edge technology meets the future of health and performance.

• Leaders in the field of Regenerative Medicine and Stem Cell Therapy.

• Dedicated to transforming the landscape of recovery and physical optimization.

• We offer state-of-the-art, non-surgical solutions that harness the body’s inherent ability to heal.

BioSpan Longevity Fund

VIRUN

BioSpan Longevity Fund

Booth #155

Booth #11104

VIRUN

300 East 39th Street., Ste 25G

1750 N. 8th St.

New York, New York, 10016

Colton, California, 92324

United States

Ph: (646) 679-8605

Ph: (909) 618-3267

Email: contact@biospanfund.com www .biospanfund .com

Email: nickols.huang@virun.com www .virun .com

BioSpan Longevity Ventures is a longevityfocused investment platform deploying capital into science-backed technologies that extend healthspan and optimize human performance. The fund targets scalable innovations across biotechnology, regenerative medicine, diagnostics, preventive health, and AI-driven personalized care. BioSpan combines institutional investment discipline with clinical rigor to back companies translating breakthrough longevity research into commercially viable, measurable outcomes that improve lifespan, vitality, and longterm human resilience.

BIOTICS RESEARCH

ENCE&NATURE

Biotics Research

VIRUN

Booth #107

Booth #11104

6801 Biotics Research Drive

VIRUN

Rosenberg, Texas, 77471

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (800) 231-5777

Email: biotics@bioticsresearch.com

Ph: (909) 618-3267

www .bioticsresearch .com

Email: nickols.huang@virun.com

www .virun .com

Biotics Research Corporation was formed in 1975 and from day one the foundation has been “Innovation and Quality.” Our goals remain unchanged - innovative ideas, carefully researched concepts, and product development with advanced analytical and manufacturing techniques to develop and produce nutritional products of superior quality and effectiveness available exclusively to healthcare professionals. This year, we are proud to celebrate 50 years of excellence in the industry.

220 W. 7th Ave.

1750 N. 8th St.

Tampa, Florida, 33602

United States

Colton, California, 92324

Ph: (888) 398-6551

United States

Ph: (909) 618-3267

Email: info@prorxpharma.com

boudreauxsnewdrug .com

Email: nickols.huang@virun.com

www .virun .com

BoomRx is a unified pharmacy technology and fulfillment platform that simplifies prescription management for clinics, med spas, and telehealth providers nationwide. It consolidates access to hundreds of 503A, 503B, brand, and generic medications into one streamlined portal with a single login and full formulary access.

Supporting 50-state shipping, fast turnaround times, competitive pricing, and flat-rate shipping, BoomRx improves operational efficiency, cost visibility, and scalability across hormone therapy, weight management, peptides, sexual health, and wellness programs.

VIRUN

BodyHealth

Booth #936

Booth #11104

745 Main St.

VIRUN

1750 N. 8th St.

Dunedin, Florida, 34698

Colton, California, 92324

United States

Ph: (877) 804-3258

Ph: (909) 618-3267

Email: wholesale@bodyhealth.com

Email: nickols.huang@virun.com

wholesale .bodyhealth .com

www .virun .com

BodyHealth is dedicated to delivering high-quality, science-backed supplements that support optimal health and daily vitality. From elite athletes to busy professionals, our products are crafted to enhance performance and overall wellness. Our flagship PerfectAmino supports protein synthesis with up to 99% utilization, helping build muscle and collagen without added calories or breaking a fast. Beyond PerfectAmino, we offer supplements for hydration, digestion, sleep, immune support, and more—each designed to optimize the body’s natural functions and long-term well-being.

Boston Heart Diagnostics

VIRUN

Booth #1035

#11104

200 Crossing Blvd

VIRUN

1750 N. 8th St.

Framingham, Massachusetts, 1702

Colton, California, 92324

United States

Ph: (877) 425-1252

Ph: (909) 618-3267

Email: customercare@bostonheart.eurofinsus. com

Email: nickols.huang@virun.com www .virun .com

bostonheartdiagnostics .com

Boston Heart Diagnostics is transforming the treatment of cardiovascular and related diseases through novel clinical diagnostics, therapeutically focused reports, and personalized, scientifically designed nutrition and lifestyle programs that have the power to change the way healthcare providers and patients communicate about heart health.

VIRUN

BodySite

Booth #

Booth #126

11104

VIRUN

230 N Congress Ave., Ste A12 Lake Park, Florida, 33408

United States

1750 N. 8th St. Colton, California, 92324

Ph: (561) 247-3839

United States

Ph: (909) 618-3267

Email: teambodysite@bodysite.com bodysite .com

Email: nickols.huang@virun.com www .virun .com

BodySite is the patient-focused practice management platform built for Functional Medicine. Beyond care plans and education, we streamline intake, charting, consent forms, ePrescribing, remote patient monitoring, lab integration, payments, and program enrollment. Build structured programs, automate workflows, track outcomes, and manage patient communication in one cohesive system. Designed for growth-minded practices, BodySite helps you scale personalized care, improve retention, increase revenue, and run your entire operation without stitching together multiple disconnected tools.

VIRUN

Boudreaux’s New Drug Store

Booth #11104

Booth #830

VIRUN

404 E Prien Lake Rd

1750 N. 8th St.

Lake Charles, Louisiana, 70601

Colton, California, 92324

United States

Ph: (337) 436-7216

Email: sales.support@bndsrx.com

Ph: (909) 618-3267

boudreauxsnewdrug .com

Email: nickols.huang@virun.com www .virun .com

Boudreaux’s New Drug Store is a national leader in compounding pharmacy, with over 100 years of experience delivering personalized medicine nationwide. Based in Louisiana and licensed across the U.S., we specialize in sterile and non-sterile compounding for weight loss, hormone optimization, longevity, wellness, and specialty therapies. We partner with providers across the country to deliver patient-specific solutions with quality, precision, and service at scale.

VIRUN

Booth #11104

VIRUN

Booth

Transform Cardiovascular Outcomes with Cutting-Edge Vascular Health Insights

Key Leverage Points

• The predictive role of the microvasculature in evaluating longevity

• Revolutionary science revealing the upstream role of the micro-thin inner lining of every blood vessel

• The importance of optimizing nitric oxide levels and blood pressure over time

• The many insults and impacts that challenge the vascular system

• The connection between oral and vascular health

• How vascular dysfunction aﬀects overall health and wellness

COURSE STRUCTURE

This comprehensive course is fully online and divided into four modules:

Foundations of Vascular Health: Exploring the vital role the vascular system plays in overall health.

The Science of Vascular Health: A deep dive into the underlying mechanisms driving vascular health.

Kristine Burke, Shawn Green, PhD

Mark Houston, MD, MS, FACP, ABAARM

Kristi HughesMorlan, ND

Helen Messier, PhD, MD, CCFP

Doreen Saltiel, MD, JD, FACC, FAARM, ABAARM

Michael Stone, MD, MS, IFMCP

Michael Twyman, MD

Brain Gauge

VIRUN

Brain Gauge

Booth

#846

Booth #11104

87 Possum Trot

VIRUN

Semore, North Carolina, 27343

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (336) 504-1256

United States

Email: info@corticalmetrics.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .corticalmetrics .com

www .virun .com

The Brain Gauge is the flagship product of Cortical Metrics, an R & D company that specializes in neuroscience research and technology. The Brain Gauge is a sensory based neurofunctional system that accurately and objectively tests and tracks brain function with the 90 second Quick Check and Standard tests that provides specificity about brain function. Additionally, the Brain Gauge Gym provides methods for individuals to improve functional performance via brain training. Over 150 publications to date utilize the methods.

VIRUN

1750 N. 8th St.

2010 Cobb Intl Blvd., Ste B Kennesaw, Georgia, 30152

United States

Colton, California, 92324

Ph: (800) 746-7640

United States

Ph: (909) 618-3267

Email: shows@bwhlabs.com

bwhlabs .com

Email: nickols.huang@virun.com

www .virun .com

For over 25 years, BWH Labs has been dedicated to providing the purest and most biologically active beta glucan on the market.

BrainMaster Technologies Inc.

VIRUN

Booth #234

Booth #11104 VIRUN

195 Willis St.

Bedford, Ohio, 44146

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (440) 232-6000

Email: sales@brainmaster.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

brainmaster .com

www .virun .com

BrainMaster offers the most cutting edge and comprehensive variety of Clinical EEG, 3D Brain Imaging, qEEG and Neurofeedback on the market. Application areas include real-time imaging utilizing sLORETA, normative databases and pre/post therapeutic comparison. Clinical and personal data-base driven Neurofeedback, biofeedback, peak-performance, research, Virtual Reality and brain-controlled systems. Add our system to your practice, and change lives, one brain at a time!

Brooksville Pharmaceuticals

VIRUN

Booth #942

Booth #11104

16410 Flight Path Dr. Brooksville, Florida, 34604

United States

VIRUN 1750 N. 8th St. Colton, California, 92324

United States

Ph: (352) 667-8135

Ph: (909) 618-3267

Email: atylander@brooksvillerx.com

Email: nickols.huang@virun.com

brooksvillerx .com

www .virun .com

Brooksville Pharmaceuticals is an independent pharmacy located in Brooksville, Florida. We are dedicated to providing friendly, outstanding, personalized service to all of our customers. Brooksville Pharmaceuticals is privately owned and operated by pharmacists. Our team has extensive experience in our current product offering and in the retail side of our business. As a result of this, we have established a great name for ourselves and take great pride in providing extra special service and individualized attention to our customers.

VIRUN

Calocurb

Booth #326

Booth #11104

VIRUN

1750 N. 8th St.

17B Farnham Street, Ste.13517, Parnell Auckland, Auckland, 1052

Colton, California, 92324

New Zealand

United States

Ph: (642) 196-5440

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: clinic@calocurb.com wholesale .calocurb .com

www .virun .com

Calocurb® is a natural supplement containing Amarasate®, a hop extract proven to significantly increase endogenous GLP-1 6.4x, CCK 6x, and PYY 1.7x over baseline. In clinical studies, Calocurb reduced average calorie intake, hunger, and cravings by 18%, 30%, and 40%, respectively. Calocurb can be used as part of a weight health program, as an ‘exit strategy’ from GLP-1 receptor agonists, or in conjunction with them. Practitioner-only Calocurb CLINICAL 250mg is now available… meet the team at booth 326.

VIRUN

Calroy Health Sciences

Booth #507

Booth #11104

14362 N Frank Lloyd Wright., Ste 1000

VIRUN

1750 N. 8th St.

Scottsdale, Arizona, 85260

Colton, California, 92324

United States

Ph: (505) 231-2115

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: support@calroy.com www .calroy .com

www .virun .com

Advancing Science. Enhancing Health. At Calroy, we translate breakthrough science into products without parallel. Through rigorous research and formulation, we develop transformative new solutions for health. Our team leads emerging scientific research, applies expertise on world-class natural ingredients, and then conducts formulationspecific research to optimize outcomes. The result is a highly focused approach, including the only dietary supplement patented to regress vulnerable plaque - Arterosil HP - and a revolutionary, long-lasting nitric oxide supplement - Vascanox HP.

VIRUN Booth

TURNKEY SOLUTIONS TO STREAMLINE YOUR SUPPLEMENT BUSINESS

Build, manage, and scale your supplement business with confidence.

Streamline Your practice

Simplify supplement management, increase revenue, and improve patient satisfaction

Fulfillment & Concierge Services

Shipping, and order management handled for you, so you can focus on growth, not logistics.

Private Label & Affiliate Programs

Build your own supplement brand or partner with us to expand your reach and revenue.

Turn-Key Solutions for Growth

Everything you need, including label design, website development, and marketing strategy.

Live US Based Customer Service

Unmatched customer support with 25 years of industry experience by your side at every stage.

VIRUN

CDRX Pharmacy

VIRUN

CellCore Biosciences + Biocidin Botanicals

Cellera

VIRUN

Booth

#543

Booth #11104

1000 Clint Moore Rd., Ste B201

VIRUN

1750 N. 8th St.

Boca Raton, Florida, 33487

Colton, California, 92324

United States

Ph: (561) 826-0711

Ph: (909) 618-3267

Email: info@cdrxpharmacy.com

Email: nickols.huang@virun.com

www .cdrxpharmacy .com

www .virun .com

CDRX Pharmacy delivers customized sterile and non-sterile compounded therapies supporting modern, outcomes-driven patient care across diverse healthcare environments. Through precision formulation, rigorous quality standards, and responsive clinical collaboration, we help healthcare professionals implement advanced treatment strategies, expand service offerings, and operate efficiently while maintaining consistency, compliance, and confidence in everyday clinical workflows.

Center City Pharmacy

Booth #946

416 Clematis St

West Palm Beach, Florida, 33401

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (561) 559-0047

United States

Ph: (909) 618-3267

Email: customersupport@centercityrx503a.com

www .centercityrx503a .com

Email: nickols.huang@virun.com

www .virun .com

A 503A & 503B compounding pharmacy with a full catalog—from anti-aging to weight loss, sterile to non-sterile solutions. Featuring our patented metered-dose liquid liposomal technology, we deliver a one-of-a-kind Liquid Liposomal Metered Dose that changes the game in patient care. Whether personalized prescriptions or large-scale supply, we provide precision, safety, and innovation nationwide— setting a new standard in compounding and helping patients and providers achieve better outcomes like never before.

Booth

#941

Booth #11104

3399 PGA Blvd., Ste 300

VIRUN

Palm Beach Gardens, Florida, 33410

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (866) 902-1525

Ph: (909) 618-3267

Email: support@cellcore.com

Email: nickols.huang@virun.com

cellcore .com

www .virun .com

CellCore + Biocidin deliver patient-first solutions that address the root causes of dysfunction. From microbial balance, biofilm disruption, and the broad-spectrum botanicals of Biocidin® 18 to detoxification, drainage, and mitochondrial support powered by BioActive Carbon®, our portfolios work together to restore energy, resilience, and long-term cellular health.

VIRUN

Central Drugs Compounding Pharmacy

Booth #11104

Booth #701

VIRUN

520 W. La Habra Blvd.

1750 N. 8th St.

La Habra, California, 90631

Colton, California, 92324

United States

Ph: (562) 691-6754

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: clinicalrph@centraldrugsrx.com centraldrugsrx .com

www .virun .com

Central Drugs is an industry leader in the art and science of custom compounding and individualized health-care solutions with a team of expert pharmacists at our state-of-the-art 503A compounding pharmacy. Central Drugs is your pharmacy partner, working with clinics to provide resources, education, and services to improve the overall health of your patients. Central Drugs specializes in compounding, seeking the most innovative, effective and trending formulations to meet the needs of clinics across 30 states.

Booth #11104

Booth #445

VIRUN

1819 West Ave.

Miami, Florida, 33139

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (305) 323-5460

Ph: (909) 618-3267

Email: drivanrusilko@gmail.com cellera .ai

Email: nickols.huang@virun.com www .virun .com

Cellera is an AI-powered Longevity Operating Ecosystem that transforms your clinic into a seamless, precision-driven wellness engine. It automatically ingests labs, intake forms, wearables, and patient history—then organizes everything into a single digital fingerprint for every patient. In seconds, Cellera generates advanced, citationbacked longevity protocols with built-in safety checks for contraindications and evidence-based recommendations. With integrated fulfillment— including e-prescribing, diagnostics, nutraceutical prescribing, and the Cellera Institute—physicians can optimize outcomes at scale while eliminating repetitive administrative work.

VIRUN

Cerbo

Booth #333

Booth #11104

VIRUN

1750 N. 8th St.

501 Union St., Ste 545 Nashville, Tennessee, 37219

Colton, California, 92324

United States

Ph: (509) 220-0770

Ph: (909) 618-3267

Email: sales@cer.bo cer .bo/explore-the-demo/

Email: nickols.huang@virun.com www .virun .com

Cerbo is simply the best EHR + Patient Portal for functional medicine. Scheduling includes online requests, custom reminders, and native telehealth. Charting is ultra-flexible, with eRx and supplements, inventory, IVs, injections, pelleting, and your custom recommendations, plus powerful templating tools. Integrated merchant services include credit/ ACH, subscriptions, and payment plans. And your Patient Portal with custom patient forms is styled to match your website. And lots more! All with incredible configuration & support. Demo: cer.bo/explore-the-demo/

VIRUN

Booth #

VIRUN

VIRUN

Circulate Health

VIRUN

Clinicians Supplement Consultants

Booth #1133

Booth #11104

1424 11th Ave., Ste 400

VIRUN

Seattle, Washington, 98122

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (206) 289-9700

Email: info@circulate.health

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .circulate .health

www .virun .com

Circulate Health advances longevity medicine through safe, expertly delivered therapeutic plasma exchange (TPE). As a dedicated clinical care provider, we partner with clinics to operationalize TPE as a validated, scalable medical service—delivered by specialized apheresis nurses and guided by standardized protocols that ensure exceptional safety, comfort, and quality.

PHARMACY

CRE8 Pharmacy

VIRUN

3700 NW 126th Avenue

Coral Springs, Florida, 33065

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (888) 224-5181

United States

Email: david@cre8rx.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .cre8pharmacy .com

www .virun .com

CRE8 Pharmacy (503A Pharmacy) offers compounding services for personalized medicine and patient-specific prescriptions. We are a team, working at creating perfect formulations, dispensing orders reliably and resolving any issues promptly. Specializing in Peptides, Hormone Replacement Therapy, Sexual Wellness, Weight Loss & Energy, Cognitive & Mental Health formulas, Sterile & Non-Sterile compounds, Generic & Brand medications. Welcome to the future of compounding pharmacy.

Booth #11104

Booth #731

VIRUN

180 Froehlich Farm Blvd.

Woodbury, New York, 11797

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (516) 222-2288

Ph: (909) 618-3267

Email: dlc@cscprivatelabel.com

Email: nickols.huang@virun.com

www .cscprivatelabel .com

www .virun .com

Clinicians Supplement Consultants allows practitioners to provide concierge service and sales of professional supplement brands and practitioners own private label supplements to their patients. CSC has an exclusive professional only brand, a concierge supplement fulfillment service, a private label development and management program. CSC allows practitioners focus on the patient while CSC handles all aspects of inventory, dispensing, fulfillment, and patient compliance . CSC handles the supplement business allowing practitioners to focus on their patients.

VIRUN

Corepay

Booth #11104

VIRUN

1750 N. 8th St.

1133 Louisiana Ave., Ste 212 Winter Park, Florida, 32789

United States

Colton, California, 92324

Ph: (407) 250-1012

United States

Ph: (909) 618-3267

Email: info@corepay.net corepay .net

Email: nickols.huang@virun.com www .virun .com

For nine years, Corepay has been a trusted payment partner for specialty and regulated industries, with deep expertise supporting healthcare and telehealth businesses. As a fullservice payment processor, we deliver secure credit card and alternative payment solutions built to meet the compliance and operational demands of modern medical commerce. Our tailored approach supports telehealth platforms, healthcare providers, med spas, longevity clinics, health and wellness brands, and subscription models, offering transparent pricing, dependable approvals, and scalable infrastructure with no hidden fees.

Cyrex Laboratories

VIRUN

Booth #11104

VIRUN

2602 S. 24th Street

1750 N. 8th St.

Phoenix, Arizona, 85034

Colton, California, 92324

United States

Ph: (602) 759-1245

Ph: (909) 618-3267

Email: Kristina.C@cyrexlabs.com

Email: nickols.huang@virun.com

www .JoinCyrex .com

www .virun .com

Cyrex Laboratories is a clinical laboratory specializing in advanced functional immunology testing. By pioneering a system-based approach, Cyrex provides healthcare practitioners with precision diagnostics that uncover hidden immune reactivity, barrier integrity dysfunction, and early predictors of autoimmunity.

With innovative test panels designed to map complex immune responses, Cyrex empowers practitioners to move beyond symptom management—helping them identify root causes and intervene earlier in the disease process.

VIRUN

Daiwa By US Jaclean, Inc.

Booth #11104

Booth #835

VIRUN

1816 W. 135th St.

1750 N. 8th St.

Gardena, California, 90249

Colton, California, 92324

United States

Ph: (310) 508-5960

United States

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: prodriguez@usjaclean.com www .daiwamassage .com

www .virun .com

U.S. Jaclean, Inc. is one of the leading health and wellness massage chairs distributors in the United States since 1982. Our mission: To improve the health and wellness of Americans through quality products that can be used from the comfort of home.

Booth #130

VIRUN

Booth #11104

A Pellet So Advanced It’s Patented

The EvexiPEL Method was engineered to raise the clinical standard, from formulation to insertion. Because advanced therapy isn’t just about what you prescribe… it’s how reliably you deliver it.

• Patented pellet formulation

• Blunt-tip trocar for controlled placement

• Designed for procedural consistency

• Built to support patient satisfaction and provider confidence

See the EvexiPEL difference at Booth 401

Learn why more practitioners are choosing the EvexiPEL Method.

VIRUN

Designer Drugs Labs

Booth #530

Booth #11104

7304 Jarnigan Rd.

VIRUN

Chattanooga, Tennessee, 37421

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (423) 954-2585

United States

Email: sales@designerdrugslabs.com

Ph: (909) 618-3267

www .designerdrugslabs .com

Email: nickols.huang@virun.com

www .virun .com

For more than 25 years, Designer Drugs has been working with patients and physicians to provide custom solutions for their pharmaceutical needs. Our pharmacy proudly compounds ophthalmics, injections, dermatologic preparations, hormone replacement options, and many more products. These preparations are designed specifically to meet individual needs with the highest level of safety and accuracy. Designer Drugs is licensed to ship prescriptions to all fifty states.

VIRUN

Diadia Health Booth #342

Booth #

433 Broadway St., Ste 601 New York, New York, 10013

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (408) 357-4347

United States

Ph: (909) 618-3267

Email: info@diadiahealth.com

diadiahealth .com

Email: nickols.huang@virun.com

www .virun .com

The best longevity clinicians don’t need more data. They need better reasoning. Diadia Health is the AI-powered reasoning layer for functional and longevity medicine — turning epigenetics, biomarkers, diagnostics, and lifestyle data to surface root drivers and personalize protocols to each unique biology. The result: faster timeto-insight, explainable recommendations your team can act on, and consistent clinical quality — whether you have one provider or twenty. Unlike any other AI, we give you full transparency and 0 tolerance for hallucinations.

VIRUN

Designs for Health

Booth #11104

Booth #601

VIRUN

31 Lupi Ct.

Palm Coast, FL 32137

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (386) 225-0135

Ph: (909) 618-3267

Email: sciencefirst@designsforhealth.com

Email: nickols.huang@virun.com

www .designsforhealth .com

www .virun .com

Our Mission: Designing a Well World We are driven by a higher purpose. We are activists for health - rooted in and united by science. Transforming boundaries, breaking barriers, setting new standards, disrupting the status quo. We believe in science-based nutrition and natural medicine, developing health products without compromise, and advancing the way education and technology support wellness for all. We design a new paradigm. We design a well world.

Diagnostic Solutions Laboratory

Booth #

VIRUN Booth #11104

928

31 Lupi Ct., Ste 230

VIRUN

Palm Coast, Florida, 32137

United States

1750 N. 8th St. Colton, California, 92324

Ph: (877) 485-5336

United States

Ph: (909) 618-3267

Email: CS@DIAGNOSTICSOLUTIONSLAB.COM

WWW .DIAGNOSTICSOLUTIONSLAB .COM

Email: nickols.huang@virun.com

www .virun .com

Diagnostic Solutions Laboratory bridges the gap between clinicians and the clinical lab with advanced testing, including the GI-MAP® stool test, StoolOMX™ add-on, OAp™ Organic Acids Profile, and OMX™ Organic Metabolomics. Our comprehensive menu uncovers root causes of symptoms and chronic conditions, delivering actionable insights clinicians can trust. From gastrointestinal health to metabolomics, our results support targeted, effective treatment plans. Elevate your practice with innovative testing from Diagnostic Solutions Laboratory that strengthen patient care and outcomes.

Detox Pure Elements, LLC

VIRUN

Booth #1114

Booth #11104

VIRUN

123 Sesame Street

1750 N. 8th St.

Tampa, Florida, 33602

Colton, California, 92324

United States

Ph: (813) 575-7934

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: customerservice@detoxpure.com detoxpure .com

www .virun .com

DetoxPure Elements is a cutting-edge supplement brand designed to help your body detoxify from harmful toxic molds and other environmental toxins. Mycotoxins, which are toxic compounds produced by mold and fungi, can accumulate in your body and impact your health in various ways—causing fatigue, brain fog, digestive issues, and more. DetoxPure Elements was developed to combat these hidden dangers and assist your body in cleansing itself naturally and effectively.

DocLoop, Inc.

VIRUN

Booth #1107

Booth #11104

14351 Commerce Way

Miami Lakes, Florida, 33016

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (702) 321-9716

Ph: (909) 618-3267

Email: jpowell@docloop.com docloop .com

Email: nickols.huang@virun.com www .virun .com

The Practice Growth Platform for Longevity, Functional, and Preventative Medicine. DocLoop brings your entire practice into sync – from AIpowered lab analysis and personalized protocols to fulfillment and patient engagement.

VIRUN

Doctor’s Data, Inc.

Booth #213

Booth #11104

3755 Illinois Ave.

VIRUN

St. Charles, Illinois, 60174

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (630) 377-8139

United States

Email: info@DoctorsData.com

Ph: (909) 618-3267

www .doctorsdata .com

Email: nickols.huang@virun.com

www .virun .com

Doctor’s Data, Inc. has provided innovative specialty testing to healthcare practitioners around the world from our advanced, CLIAlicensed clinical laboratory since 1972. A specialist and pioneer in essential and toxic elemental testing, the laboratory provides a wide array of functional testing to aid in decision making and better patient outcomes. Choose DDI to help you assess and treat heavy metal burden, nutritional deficiencies, gastrointestinal function, hormone status, cardiovascular risk, liver and metabolic abnormalities, and more.

DX Web Management LLC

VIRUN

5355 Town Center Rd.

VIRUN

Boca Raton, Florida, 33486

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (561) 544-7944

United States

Email: info@dx-web.com

Ph: (909) 618-3267

www .dx-web .com

Email: nickols.huang@virun.com

www .virun .com

DxScript is an AI-driven, cloud-based ePrescribing solution with EPCS, PDMP, and a patient portal, designed to function as a stand-alone or fully integrated application within your health system. The platform is mobile-ready, certified, and built for fast deployment. DxScript offers seamless integration with EMR and EHR systems and provides unmatched 24/7 live, U.S.-based customer support to ensure providers have reliable access and assistance at all times.

United States

Colton, California, 92324

Ph: (210) 872-4621

United States

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: grayson@dosedaily.co dosedaily .co

www .virun .com

VIRUN

DUTCH Test

Booth #11104

Booth #201

3138 NE Rivergate

McMinnville, Oregon, 97128

VIRUN 1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (503) 687-2050

Email: events@dutchtest.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .dutchtest .com

www .virun .com

Precision Analytical’s DUTCH Test® (Dried Urine Test for Comprehensive Hormones) helps practitioners answer complex clinical questions by providing the most comprehensive hormone monitoring results with simple patient collection. Our rigorous pursuit for the truth in hormone testing has produced three peer-reviewed studies proving the effectiveness of our 24-hour, four spot, dried urine testing as an alternative to serum (blood) or saliva for monitoring a variety of hormone therapy applications.

Dynamic DNA Laboratories

VIRUN

Booth

#635

Booth #11104

VIRUN

1750 N. 8th St.

2144 E. Republic Rd. Springfield, Missouri, 65804

Colton, California, 92324

United States

Ph: (417) 319-1047

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: info@dynamicdnalabs.com dynamicdnalabs .com

www .virun .com

Dynamic DNA Laboratories is a CLIA-certified genetics lab specializing in personalized DNA testing for clinical, wellness, and lifestyle optimization. We translate genetic insights into actionable guidance across nutrition, fitness, skin, substance response, mental wellness, pharmacogenomics, disease predisposition screening, and emerging areas of human performance. Our sciencedriven, consumer-friendly reports empower practitioners and individuals to make informed, personalized health decisions - bridging advanced genomics with integrative and functional medicine. All testing is performed in-house, ensuring accuracy, faster turnaround times, and competitive pricing.

VIRUN

Echolight Medical

Booth

Booth #934

#11104

VIRUN 1750 N. 8th St.

1800 West Loop South., Ste 1600 Houston, Texas, 77027

United States

Colton, California, 92324

Ph: (484) 800-6268

United States

Ph: (909) 618-3267

Email: info@echolightmedical.com us .echolightmedical .com

Email: nickols.huang@virun.com www .virun .com

Echolight provides Radiofrequency Echographic Multi Spectometry (REMS) technology, an ultrasound-based bone density scan that is an alternative to DXA scans. This technology is portable, with no lead-lined room required and is a better choice for pregnant patients as well as pediatric and oncology patients for monitoring bone health. See a demonstration in our booth. Echolight is headquartered in Italy and in 2020, opened offices in the United States.

Science. Soul. Service.

At this year’s Spring Congress, come meet with our compounding pharmacists, dedicated to helping your patients and practice thrive.

And we’ve spent more than 25 years helping providers grow their practice by creating treatments precisely tailored to each patient.

Our Areas of Expertise Include: We’re Licensed in All 50 States. Visit Booth 530 to explore how we can collaborate to benefit your patients, your team, and your practice.

Bio-Identical Hormone Replacement Therapy

NAD+ Injection and Nasal Spray

Eye Health and Anti-Aging Ophthalmics

Methylene Blue and GHK-Cu Peptide

VIRUN

ecoNugenics

Booth

#331

Booth #11104

VIRUN

1750 N. 8th St.

811 Broad St., Ste 600 Chattanooga, Tennessee, 37402

United States

Colton, California, 92324

Ph: (800) 308-5518

United States

Email: sales@econugenics.com

Ph: (909) 618-3267

www .pro .econugenics .com

Email: nickols.huang@virun.com

www .virun .com

ecoNugenics was founded in 1995 by an integrative medicine pioneer, to provide evidencebased health solutions. Our professional line of formulas and protocols are designed to offer powerful results, addressing today’s most critical health concerns. We have built a reputation as an industry leader in nutraceutical science, driven by a commitment to clinical substantiation. Our mission is to partner with healthcare practitioners to improve patient outcomes with, clinically effective ingredients, formulas, and protocols.

VIRUN

Elite Tax Strategists

Booth #243

Booth #11104 VIRUN

312 S. Black Horse Pike

Blackwood, New Jersey, 8012

United States

1750 N. 8th St. Colton, California, 92324

Ph: (609) 254-9650

United States

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: info@elitetaxstrategists.com elitetaxstrategists .com

www .virun .com

Elite Tax Strategists is a specialized advisory firm based in New Jersey that serves medical providers and high-income professionals nationwide. The firm helps clients reduce tax liability through advanced, fully compliant tax strategies. Unlike traditional accountants who focus primarily on filing tax returns, Elite Tax Strategists goes beyond compliance. We prepare accurate and timely tax returns while also designing proactive, forward-looking tax strategies. When needed, we collaborate with your CPA to ensure seamless coordination and maximum tax efficiency.

VIRUN

Emergentmedtech

Booth #11104

#1040

VIRUN

27 Eayres Pond Rd

1750 N. 8th St.

Hudson, New Hampshire, 3051

Colton, California, 92324

United States

Ph: (401) 300-2294

Ph: (909) 618-3267

Email: edwin@emergentmedtech.com emergentmedtech .com

Email: nickols.huang@virun.com www .virun .com

EmergentMedTech delivers next-generation regenerative technologies to forward-thinking aesthetic practices across the country. As the most established NeoGen PSR distributor, and official Cell Sound distrubutor in the US, we combine powerful devices with real partnership, offering clinical expertise, strategic growth support, and performance-backed confidence.

VIRUN

EndoAxis

Booth #1047

#11104

Endymed Medical Inc.

VIRUN

Booth #944

Booth #11104

VIRUN

21 Esfahan Drive

824 Sheridan Rd.

1750 N. 8th St.

San Jose, California, 95111

Colton, California, 92324

United States

Ph: (669) 333-3823

Email: Contact@eNavvi.com

Ph: (909) 618-3267

enavvi .com/home

Email: nickols.huang@virun.com

www .virun .com

eNavvi is a physician-built digital prescribing platform that connects clinicians to a nationwide network of PCAB-accredited compounding pharmacies, enabling secure digital prescribing outside of the EHR. The platform supports personalized care by improving access, transparency, and prescribing efficiency— anywhere, on any device.

1750 N. 8th St.

Glencoe, Illinois, 60022

United States

Colton, California, 92324

Ph: (708) 406-5154

United States

Ph: (909) 618-3267

Email: cs@endoaxis.com

Email: nickols.huang@virun.com

www .endoaxis .com

www .virun .com

EndoAxis is a precision-focused hormone health platform transforming how practitioners interpret complex lab results and support patients. Using advanced pattern recognition, it analyzes hormone, gut, and endocrine data to deliver clear, actionable insights. Founded to empower providers with rapid analysis and tailored solutions, EndoAxis blends naturopathic expertise with evidence-based care. Its bespoke formulations, known as precision hormone care in a bottle, address individual hormonal patterns holistically and focus on restoring systemic balance rather than simply relieving symptoms.

4400 Rt. 9 South., Ste 1000

Freehold, New Jersey, 7731

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (855) 363-9633

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: salesusa@endymed.com endymed .com

www .virun .com

EndyMed Medical is a global aesthetic technology company known for its proprietary 3DEEP® RF technology, designed to deliver comfortable, consistent energy for skin tightening and rejuvenation. Our systems help practices expand treatment offerings with predictable results across face and body, backed by hands-on clinical education and responsive support. Visit us to see what’s new and learn how EndyMed can elevate outcomes and patient experience.

Booth

VIRUN Booth #11104

Booth

VIRUN

VIRUN

Ergo-Flex Technologies

Booth #834

Booth #11104

VIRUN

1750 N. 8th St.

136 Poplar Circle., Ste 403 Conroe, Texas, 77304

United States

Colton, California, 92324

Ph: (936) 588-5510

United States

Email: sales@ergoflextechnologies.com

Ph: (909) 618-3267

www .ergoflextechnologies .com

Email: nickols.huang@virun.com

www .virun .com

Ergo-Flex Technologies a company that designs and deploys non-invasive, drug-free systems to support athletic performance, recovery, and long-term cellular wellness. Our equipment is intentionally engineered to be simple to operate, highly reliable, and turnkey, requiring minimal training while integrating seamlessly into highperformance, medical, and recovery environments.

Ergo-Flex systems are in use across 2,500+ locations nationwide and 8 other countries, including medical practices, physical therapy and chiropractic clinics, professional and collegiate training environments, gyms, wellness facilities, Medi-spas, and select high-net-worth clients.

E X O C E U T I C A L S

VIRUN

Exoceuticals

Booth #1134

VIRUN

641 Lexington Ave., 15th floor

New York, New York, 10022

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (212) 584-4178

United States

Ph: (909) 618-3267

Email: cs@exoceuticals.com

www .exoceuticals .com

Email: nickols.huang@virun.com

www .virun .com

Exoceuticals is a science-first skin longevity brand redefining topical skincare by using a patented exosome technology and other innovative ingredients. Powered by clinically studied eXo³ and aloe³ Exosomes, our formulas work at the cellular level to help support regeneration, repair, and resilience. Delivering high-performance, fragrance-free skincare designed for long-term skin health is at the core of everything we do. Exoceuticals makes premium products in the skin, hair and personal care categories.

VIRUN

EVEXIAS Health Solutions

Booth #11104

Booth #401

VIRUN

920 S. Kimball Ave., Ste 100

Southlake, Texas, 76092

United States

1750 N. 8th St. Colton, California, 92324

Ph: (817) 725-9677

United States

Ph: (909) 618-3267

Email: Tripp.Bushnell@evexias.com

Email: nickols.huang@virun.com

www .evexias .com

www .virun .com

EVEXIAS® Health Solutions, LLC., is privately owned, based in Southlake, Texas, founded in 2018. Since that time EVEXIAS has proudly redefined the standard for personalized healthcare, including the innovative EvexiPEL Method.

EVEXIAS has a clear mission: Restore balance and vitality through innovative hormone therapies that treat the whole person, not just symptoms.

We strive to ensure patients live healthier, more fulfilling lives, while enabling practices to thrive in today’s rapidly evolving healthcare landscape.

Evoskin

VIRUN

Booth

#25

Booth #11104

4300 Biscayne Blvd., Ste 303 Miami, Florida, 33137

United States

VIRUN 1750 N. 8th St. Colton, California, 92324

United States

Ph: (802) 386-7546

Email: info@evoskin.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

WWW .EVOSKIN .COM

www .virun .com

Evoskin is a U.S. distributor of advanced regenerative and aesthetic medical technologies for plastic surgeons, dermatologists, cosmetic physicians, and longevity-focused practices. We specialize in science-driven solutions including Endoret® PRGF®, a next-generation autologous growth factor system, and LongevHA™, a noncrosslinked hyaluronic acid enhanced with NAD+, mannitol, resveratrol, and peptides. Our portfolio is carefully selected for clinical innovation, safety, and strong ROI, supported by exceptional customer service and warranties.

VIRUN

fatty15

Booth #11104

Booth #831

VIRUN

2907 Shelter Island Dr., Ste 105-411

San Diego, California, 92106

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (619) 407-9225

Ph: (909) 618-3267

Email: HCP@fatty15.com

Email: nickols.huang@virun.com

fatty15.com

www .virun .com

Fatty15 was founded following Dr. Stephanie Venn-Watson’s groundbreaking discovery of C15:0, the first essential fatty acid since omega-3, over 90 years prior. Stephanie and her husband, Dr. Eric Venn-Watson, developed the first pure C15:0 supplement available, aiming to address nutritional C15:0 deficiencies, which effects up to one-third of the global population. Fatty15 was launched as a dietary supplement in 2021 in order to replenish global C15:0 levels and became the Inc. 5000 fastest growing supplement company in America in 2025.

VIRUN

FirmTech

Booth #747

Booth #11104

VIRUN

7466 Cottonwood Rd. Bozeman, Montana, 59718

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (609) 468-0234

Ph: (909) 618-3267

Email: info@myfirmtech.com www .myfirmtech .com

Email: nickols.huang@virun.com www .virun .com

At FirmTech, we’ve developed a revolutionary FDA-registered wearable smart device and mobile app that are transforming preventive healthcare by monitoring sexual and nocturnal erections, which serve as vital indicators of both sexual function and cardiovascular health. Our TechRing provides men and their healthcare providers with objective, personal, and actionable data to assess health status and treatment eligibility, and then monitor progress over time.

Booth #11104

Security Cap DoseLockTM Base with Integrated Safety Tabs — Senior Friendly Design

Flavent Relief LLC

VIRUN

Booth #1105

Booth #11104

540 B Road

VIRUN

Labelle, Florida, 33935

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (863) 674-5775

United States

Email: Flavent Relief LLC

Ph: (909) 618-3267

www .flaventrelief .com

Email: nickols.huang@virun.com

www .virun .com

Flavent Relief LLC stands out as a beneficial wellness brand by leveraging botanical flavonoids—powerful plant compounds known in longevity science for their antioxidant, antiinflammatory, and cellular-protective properties. Proprietary blends with quercetin, rutin, luteolin, apigenin, and more target aging pathways via tinctures, topicals, powders, and chews. Promoting the “flavonoid entourage effect” for superior bioavailability and broad-spectrum benefits, Flavent aids inflammation control, brain vitality, immune support, and cellular health— core elements of natural, plant-based healthy aging and extended health span.

Fujiiryoki

Booth #240

VIRUN

1750 N. 8th St.

371 Van Ness Way.,Ste 220 Torrance, California, 90501

United States

Colton, California, 92324

Ph: (757) 839-5314

United States

Ph: (909) 618-3267

Email: Myles.dessi@fujiiryoki.com

Email: nickols.huang@virun.com

syncamassagechair .com

www .virun .com

Leader in massage chair technology.

Virun is an established cGMP-certified liquid dietary supplement manufacturer headquartered in Southern California, with over 25 years of industry expertise.

Specialized in turnkey, custom private-label liquid supplement manufacturing—offering everything from formulation to bottling and pouching—all under one roof. To better serve international clients, Virun also provides manufacturing capabilities for the European market through our facility in Dublin, Ireland.

VIRUN

Flowpresso

Booth #11104

Booth #336

VIRUN

5900 Balcones Drive., Ste 100

Austin, Texas, 78731

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (941) 404-0619

Ph: (909) 618-3267

Email: nick@flowpressousa.com

Email: nickols.huang@virun.com

www .flowpressousa .com

www .virun .com

Medella Health is revolutionizing the landscape of health and wellness with state-of-the-art, non-invasive lymphatic drainage technology. Their product, Flowpresso®, is a cutting-edge, non-invasive lymphatic drainage suit with FDA Class II Medical Device clearance designed to support the body’s natural healing processes through the delivery of a three-in-one treatment of deep pressure stimulation, heat, and compression. This innovative technology improves lymphatic drainage and restores a “flow state” to the body, thereby promoting relaxation, repair, and performance.

Fullscript

VIRUN

Booth

#311

Booth #11104

VIRUN

1750 Elm St., #1200

Manchester, New Hampshire, 3104

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (866) 807-3828

Email: support@fullscript.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

fullscript .com

www .virun .com

Fullscript empowers healthcare providers to deliver the personalized care patients deserve — more confidently and efficiently — by capturing clearer clinical insights, fueling smarter supplement plans, and promoting ongoing engagement. Join 125,000+ providers building the future of whole person care today.

FoodMarble

VIRUN

Booth #145

Booth

#11104

VIRUN

Guinness Enterprise Centre, Taylor Dublin, Dublin, D08T1WY

Ireland

1750 N. 8th St. Colton, California, 92324

United States

Ph: (860) 333-8721

Ph: (909) 618-3267

Email: gwenn@foodmarble.com foodmarble .com/gi

Email: nickols.huang@virun.com www .virun .com

FoodMarble is the world’s first personal hydrogen and methane breath tester. The MedAire2 device provides objective data for treatment of IBS. It is a practice-changing device- it can be used for SIBO testing as well as lactose, fructose, sucrose and other food intolerance testing. Patients perform the tests at home through an appguided process. There is no extra cost to patients for repeat testing so we are able to treat SIBO and IBS more effectively.

VIRUN

GAINSWave

Booth #913

Booth #11104

VIRUN

2980 NE 207th St., #503

1750 N. 8th St.

Aventura, Florida, 33180

United States

Colton, California, 92324

United States

Ph: (855) 383-5779

Ph: (909) 618-3267

Email: team@gainswave.com

gainswave .com

Email: nickols.huang@virun.com www .virun .com

GAINSWave empowers providers to deliver next-generation shockwave therapy for overall regenerative health as well as sexual wellness. Backed by proven protocols, advanced technology, and a nationwide network of trained providers, we help clinics elevate patient outcomes while building thriving, future-ready practices.

VIRUN

Booth #11104

NEOGEN PSR®

Nitrogen Plasma Skin Regeneration

7 FDA-approved indications

Resurfaces, regenerates & tightens

Non-ablative, treats all skin layers

From gentle renewal to full resurfacing

CELLSOUND® AESTHETICS

Electrosonic Resonance® Technology

Non-invasive body contouring & skin tightening

Reduces cellulite & stimulates collagen

Multi-zone treatment: face & body

Zero downtime

GB HealthWatch

VIRUN

Booth #533

Booth #11104

VIRUN

1750 N. 8th St.

6310 Greenwich Drive., Ste 100 San Diego, California, 92122

United States

Colton, California, 92324

Ph: (858) 788-9274

United States

Email: support@gbhealthwatch.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .gbhealthwatch .com/gbinsight

www .virun .com

GB HealthWatch is a genetic-based preventive health and longevity company. Our flagship GB Longevity100 Suite uses advanced nextgeneration sequencing to identify genetic markers of longevity and modifiable risks for cardiometabolic and age-related diseases. We translate genetic insights into personalized, evidence-based action plans that enable proactive prevention and optimization of healthspan and lifespan. GB genetic testing is used by leading hospitals and clinics to support precision and preventive medicine.

Genova Diagnostics

Zillicoa Street

Asheville, North Carolina, 28801

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (828) 210-7362

United States

Ph: (909) 618-3267

Email: info@gdx.net

Email: nickols.huang@virun.com

www .gdx .net

www .virun .com

Genova Diagnostics is a leading force in the world of healthcare, transforming the way chronic diseases are diagnosed, treated, and prevented. With a focus on empowering individuals to achieve optimal well-being, our advanced lab testing methodologies target crucial areas like gut health, nutritional status, immune function, and hormonal health. At Genova, we’re shaping a brighter and healthier future, where innovative approaches to personalized healthcare empower individuals to thrive. Learn more at www.gdx.net/getstarted

VIRUN

Generation Lab

Booth #11104

Booth #1139

VIRUN

1701 Bayshore Hwy.

Burlingame, California, 94010

United States

1750 N. 8th St. Colton, California, 92324

Ph: (626) 628-5068

United States

Email: info@generationlab.co

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .virun .com

Generation Lab is a longevity diagnostics company spun out of UC Berkeley and built on Dr. Irina Conboy’s 20+ years of pioneering aging research. Our SystemAge™ platform measures biological age and pace of aging across 21 organ systems using 460+ biomarkers transforming raw biological data into personalized, science-backed longevity care. We empower clinicians and patients to slow aging, reduce disease risk, and track measurable progress with precision.

VIRUN

Genesis Regenerative

Booth

#746

Booth #11104

VIRUN

15500 Roosevelt Blvd. Clearwater, Florida, 33760

United States

1750 N. 8th St. Colton, California, 92324

Ph: (410) 703-4569

United States

Email: levans@novobioalliance.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .genesisregenerative .com

www .virun .com

Genesis Regenerative provides advanced regenerative therapies that enhance patient quality of life and support clinicians in healing the “whole patient.” Regenerative Protein Array (RPA) represents advanced science in human regeneration, consisting of a sophisticated array of proteins, growth factors, and cytokines derived from placental tissue. By modifying the cellular environment through key biological messaging, RPA delivers a concentrated source of bioactive regenerative components that play a pivotal role in tissue regeneration and overall healing outcomes.

VIRUN

Genus Lifesciences

Booth

Booth #

#15

11104

514 North 12th Street

VIRUN

1750 N. 8th St.

Allentown, Pennsylvania, 18102

Colton, California, 92324

United States

Ph: (610) 782-9780

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: Info@GenusLifesciences.com genuslifesciences .com

www .virun .com

Genus Lifesciences, founded in 1999, is a manufacturer of branded and generic pharmaceutical products, headquartered in Allentown, PA. Genus Lifesciences is one of the leading companies in the United States successful in obtaining FDA approval for marketed unapproved drugs.

VIRUN

Global Life Rejuvenation

Booth #11104

Booth #436

VIRUN

168 East Main Street (Route 53)

1750 N. 8th St.

Denville, New Jersey, 7834

Colton, California, 92324

United States

Ph: (866) 793-9933

Email: Contact@GlobalLifeRejuvenation.com

Ph: (909) 618-3267

GlobalLifeRejuvenation .com

Email: nickols.huang@virun.com

www .virun .com

Join our Nationwide Network of Providers! We do the heavy lifting that most front office staff doesn’t have time for. Our highly trained staff nurtures HRT/TRT leads For You. We take the time to educate, schedule, order products from top compounding pharmacies, stem cell & biologic companies, and ensure patient treatment compliance & follow-up retention.

You treat the patient - Leave the rest to us! Global Life Rejuvenation - A Leader in Anti-Aging Medicine & HRT/TRT for Men and Women

VIRUN

Hallandale Pharmacy

Booth #613

Booth #11104

2666 SW 36th Street

VIRUN

Fort Lauderdale, Florida, 33312

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (954) 455-3822

United States

Email: Hallandalerx.com

Ph: (909) 618-3267

www .Hallandalerx .com

Email: nickols.huang@virun.com

www .virun .com

Hallandale Pharmacy is a 503a designated and PCAB accredited compounding pharmacy that is committed to providing quality and affordable custom prescription formulations nationwide. The cGMP guidelines that Hallandale Pharmacy has adopted is led by our Quality Assurance team and supporting staff. While quality is the foundation of our practice, our service to our patients and providers drives our mission. We regard our relationships with our trusted practitioners as a partnership.

VIRUN

Hillstone Pharmacy

Booth #1141

9947 Kingston Pike

VIRUN

Knoxville, Tennessee, 37922

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (865) 909-9713

Email: support@hillstonepharmacy.com

Ph: (909) 618-3267

www .hillstonepharmacy .com

Email: nickols.huang@virun.com

www .virun .com

Hillstone Pharmacy is redefining personalized medicine through precision compounding. As a trusted 503A pharmacy, we partner with forwardthinking providers to deliver customized therapies that elevate patient outcomes across hormone health, dermatology, weight management, and wellness. Backed by rigorous quality standards and modern compounding innovation, Hillstone blends clinical expertise with responsive service; helping practices move beyond one-size-fitsall care and into truly individualized treatment solutions.

VIRUN

Heads Up

Booth #11104

Booth #627

VIRUN

4400 N Scottsdale Rd Suite 9445

Scottsdale, Arizona, 85251

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (602) 671-3074

Ph: (909) 618-3267

Email: sales@headsup.health

Email: nickols.huang@virun.com

www .headsuphealth .com

www .virun .com

Heads Up is an AI-powered clinical intelligence platform that unifies and structures all client data - labs and wearables, EHRs, devices, and lifestyle inputs - into a single, clean longitudinal record. Practitioners gain a complete view without jumping between portals.With AI tools like pre-visit briefs, change summaries, natural language queries, and structured data extraction, Heads Up is your clinical co-pilot. Agentic AI surfaces cross-domain insights and automates workflows, shifting care toward proactive, preventive medicine.

VIRUN

Booth #11104

1250 S. Capital of TX Hwy.1-360

VIRUN

1750 N. 8th St.

Austin, Texas, 78746

United States

Colton, California, 92324

Ph: (512) 448-4477

United States

Ph: (909) 618-3267

Email: professional@humann.com

Email: nickols.huang@virun.com

www .pro .humann .com

www .virun .com

Humann is a leading cardiovascular health company helping people ages 18 to 120 support heart health, healthy blood pressure, boost energy, endurance, and recovery. Founded in 2009 and incepted from a University of Texas Health Science Center research program, Humann translates breakthrough science into performance-driven supplements. Trusted by more than 200 professional and collegiate teams, Humann is a 10-time Inc. 5000 honoree, with over 700 million doses delivered and 27 million products sold. Used by over 6,000 medical professional offices.

Healthgevity

VIRUN

Booth #541

Booth #11104

21a Allen Ave

VIRUN

1750 N. 8th St.

Allenhurst, New Jersey, 7711

Colton, California, 92324

United States

Ph: (833) 940-4898

Ph: (909) 618-3267

Email: support@healthgev.com

Email: nickols.huang@virun.com

www .healthgev .com

www .virun .com

Healthgevity pioneers natural bioactives and peptides to enhance longevity, optimize healthspan, and elevate well-being. In collaboration with leading physicians and scientific partners, we advance precision signaling nutrition—translating cutting-edge research into clinically informed, mechanism-driven formulations. Each product is meticulously crafted for efficacy and safety, empowering practitioners and individuals with science-driven solutions that target the biological pathways of aging and support resilient, long-term health. Our mission is to make the future of longevity accessible today.

Hydro Heal

VIRUN

Booth #1130

Booth #11104

VIRUN

1985 Longwood Lake Mary Rd. Longwood, Florida, 32750

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (866) 775-5411

Ph: (909) 618-3267

Email: Info@HydroHeal.com hydroheal .com

Email: nickols.huang@virun.com www .virun .com

Hydro Heal isn’t just another add-on, it’s a gamechanger. Infused with Molecular Hydrogen, Hydro Heal amplifies treatment results from the inside out reducing inflammation, neutralizing oxidative stress, and accelerating posttreatment recovery.

Booth #11104

Memory decline is one of the most feared consequences of aging.

Nothing works well, until now.

Peer-reviewed research demonstrated a 226% improvement in memory performance in older adults: #1 Neuroscience paper of the last 5 years. And the biggest memory improvement ever discovered.

This comes from nightly Olfactory Enrichment therapy delivered during sleep. 20 studies now show it’s causal, not merely correlational.

Developed with Neuroscientist and Professor Michael Leon of University of California Irvine. And ranked in the Top 1% of All Scientists Worldwide.

No drugs. No pills. No protocols. No work.

Just structured neurostimulation and neuroplasticity during sleep. All from gentle and pleasant Olfactory Enrichment.

VIRUN

i-On By Dr. Xi Skincare

IGNITON

VIRUN

Booth #1119

Booth #11104

15 Heather Ridge Ln.

VIRUN

Montvale, New Jersey, 7645

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (201) 925-1988

United States

Ph: (909) 618-3267

Email: DrXiHuang@ionskincare.com

Email: nickols.huang@virun.com

www .ionskincare .com

www .virun .com

i-On By Dr. Xi is a science-driven skincare and wellness brand founded by Dr. Xi Huang, a former NYU medical school professor and ironbiology researcher. i-On pioneers a clinically proven anti-aging paradigm by addressing excess iron-driven oxidation through its patented DeIronizing Inducer (DII®) technology, delivered through advanced topical skincare and targeted ingestible formulations to support whole-body balance, boost energy, reduce discomfort, and enhance beauty.

491 N. Wendover Rd.

Charlotte, North Carolina, 28211

United States

1750 N. 8th St. Colton, California, 92324

Ph: (980) 256-2022

United States

Email: discovery@goinfusive.com

Ph: (909) 618-3267

www .goinfusive .com

Email: nickols.huang@virun.com www .virun .com

Easily scale your wellness clinic with ZERO confusion Or chaos. WE HANDLE EVERYTHING: Inventory, Vendors, Procurement & PricingBy Installing Our Dedicated Team & Software Solution. Infusive is the ONLY dedicated team management solution, and software platform for all your clinic’s needs. We take supply chain chaos off your plate—centralizing vendors, securing better pricing, and safeguarding your clinic from constant disruptions.Clinics trust us because we deliver stability, transparency, and growth.

Booth #11104

Booth #519

VIRUN

833 W. South Boulder Rd., Bldg. G Louisville, Colorado, 80027

United States

1750 N. 8th St. Colton, California, 92324

Ph: (303) 222-3440

United States

Ph: (909) 618-3267

Email: info@igniton.com

Email: nickols.huang@virun.com

igniton .com

www .virun .com

Igniton™ is the world’s only quantum wellness company developing clinically studied supplements enhanced with ignitons—neutral, subatomic quasi-particles embedded using advanced cold plasma and laser photonics systems. Our formulations are designed to support biofield coherence, cognitive performance, stress resilience, and healthy aging. Backed by university studies published in peer-reviewed journals, Igniton bridges quantum physics, systems biology, and integrative longevity science to elevate human performance without pharmaceuticals.

VIRUN

2299 Summer St., #1095

Stamford, Connecticut, 6905

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (617) 216-5568

United States

Email: marketing@jona.health

Ph: (909) 618-3267

jona .health

Email: nickols.huang@virun.com

www .virun .com

Jona is a clinical-grade gut microbiome platform that uses shotgun metagenomic sequencing and AI to translate gut microbiome science into clear, personalized insights. Built on shotgun metagenomic sequencing and AI informed by 220,000+ peer-reviewed studies, Jona maps individual gut microbiome data to a wide range of health and disease patterns— including metabolic, neurological, hormonal, skin, and performance outcomes. Using digitaltwin modeling, Jona generates transparent, evidence-based, and editable action plans that evolve with a patient’s goals and clinical context.

VIRUN

InBody

Booth #207

Booth #11104

VIRUN

13850 Cerritos Corporate Dr., Unit C Cerritos, California, 90703

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (323) 932-6503

Ph: (909) 618-3267

Email: convention@inbody.com www .inbodyusa .com

Email: nickols.huang@virun.com www .virun .com

Since 1996, InBody has grown from a biotech startup to a multinational corporation serving 100+ countries across medical, fitness, research, and wellness industries. Our comprehensive ecosystem includes professional body composition analyzers, fall risk assessment devices, smart consultation kiosks, consumer products, cloud platforms, and educational solutions. Validated by 5,500+ clinical studies, InBody’s medical-grade technology empowers healthcare and fitness professionals worldwide with precise, actionable data that drives better client outcomes. Learn more at inbody.com.

KBMO Diagnostics

VIRUN

Booth #426

Booth #11104

VIRUN

4 Business Way

1750 N. 8th St.

Hopedale, Massachusetts, 2332

Colton, California, 92324

United States

Ph: (617) 933-8130

Ph: (909) 618-3267

Email: jwhite@kbmodiagnostics.com kbmodiagnostics .com

Email: nickols.huang@virun.com www .virun .com

KBMO Diagnostics is an integrated medical diagnostics company known for its patented Food Inflammation Test (FIT), which measures sensitivities to 176 foods, colorings, and additives. Built on a commitment to empowering practitioners and patients, KBMO has expanded into advanced molecular diagnostics, including its next-generation Organic Acids (MIP) and Glyphosate tests. In partnership with leading experts, the company provides comprehensive testing solutions along with educational resources that support improved patient health and informed clinical decision-making.

Booth #11104

Jona

Booth #235

KeraFactor

VIRUN

Booth #1146

Booth #11104

9663 S. Santa Monica., Ste 586

VIRUN

Beverly Hills, California, 90210

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (813) 431-8088

Email: Kerafactor@skinqri.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .mykerafactor .com

www .virun .com

KeraFactor is a science driven scalp and hair health company dedicated to restoring thicker, stronger, healthier looking hair through advanced growth factor technology. Our patented formulations combine bioengineered peptides, biomimetic proteins, and targeted delivery systems to support follicle vitality and optimize scalp function. Designed for both in office treatments and at home care, KeraFactor partners with leading physicians worldwide to deliver clinically backed, drug free solutions that elevate results and redefine modern hair rejuvenation globally.

Klotho Skin

VIRUN

Booth #434

Booth #11104

VIRUN

1750 N. 8th St.

655 Redwood Highway., Ste 160 Mill Valley, California, 94941

Colton, California, 92324

United States

Ph: (310) 874-8706

United States

Ph: (909) 618-3267

Email: Gail.Humble@klothoskin.com

Email: nickols.huang@virun.com

www .klothoskin .com

www .virun .com

Klotho Skin is a biotech company introducing an innovative skin care line. Our patented process utilizes mesenchymal stem cells genetically modified to up-regulate the age suppressor gene Klotho. We have the first and only viable human cell line modified to produce second generation growth factors and the Klotho protein. Our cellular studies suggest Klotho Skin reverses skin atrophy and increases type IV collagen after exposure to UVB insult. Klotho Skin is regenerative, protective, and preventative.

VIRUN

Kimera Labs, Inc

Booth #11104

Booth #1037

VIRUN

2810 N Commerce Pkwy

Miramar, Florida, 33025

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (305) 454-7836

Email: info@kimeralabs.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .kimeralabs .com

www .virun .com

Kimera Labs is the leading exosome biotechnology laboratory specializing in the production of perinatal mesenchymal stem cell (MSC)–derived exosome products for cosmetic and research applications. Through rigorous scientific validation, advanced manufacturing standards, and a commitment to purity and consistency, Kimera Labs delivers high-quality exosome products trusted by professionals.

Kiwi Biosciences (FODZYME)

VIRUN

Booth #443

Booth #11104

VIRUN

1750 N. 8th St.

68 Harrison Ave., Ste 605 PMB 75731 Boston, Massachusetts, 2111

Colton, California, 92324

United States

Ph: (857) 257-4948

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: partners@fodzyme.com fodzyme .com

www .virun .com

FODZYME® is a clinically validated enzyme blend that helps patients enjoy foods they love without FODMAP-related symptoms. Its targeted formula breaks down fructans, GOS, and lactose. At its core is a proprietary fructan hydrolase, the only enzyme shown to efficiently degrade the broad spectrum of fructans found in garlic, onion, and wheat. Delivered as an easy-to-use powder, FODZYME® works at first contact with food, offering greater efficacy than encapsulated enzymes and helping patients expand diets and restore food confidence.

Life Support Health Products

VIRUN

Booth #116

Booth #11104

800E. 101st Terr., Ste 100

Kansas City, Missouri, 64131

United States

VIRUN 1750 N. 8th St. Colton, California, 92324

United States

Ph: (816) 673-1230

Ph: (909) 618-3267

Email: info@lifesupporthp.com

www .lifesupporthp .com

Email: nickols.huang@virun.com

www .virun .com

As a company, we seek to create the highest quality supplements that exist in the world. All products are created by a functional medicine doctor who is currently in practice. We have solved the problem of having to take too many pills by creating concentrated products that deal with all aspects of a patients biochemistry. We know compliance is key for a patient to get a result and start referring. Let the healing begin.

LifeMetrics

VIRUN

Booth #937

Booth #11104

6507 Jester Blvd., Ste 5120-Q

Austin, Texas, 78750

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (512) 517-4867

Ph: (909) 618-3267

Email: kaylynn@lifemetrics.com lifemetrics .com

Email: nickols.huang@virun.com www .virun .com

LifeMetrics is a multi-omics health intelligence platform that empowers practitioners to deliver personalized, science backed programs using advanced genetics and lab diagnostics. Through GeneMetrics and FullMetrics, we translate complex data into clear, actionable reports under your brand. Clinics use LifeMetrics to improve patient outcomes, increase retention, and grow revenue through modern, scalable diagnostic solutions.

Balance is the Foundation of Longevity.

Longevity isn’t built on isolated interventions — it’s built on stable physiology. When the terrain is supported and systems are balanced, the body responds as it was designed to — moving from survival mode to sustainable vitality.*

Optimize drainage pathways to prepare the body for e ective detoxiﬁcation*

Intelligently bind and clear toxins to reduce total toxic burden*

Support microbial terrain balance without overwhelming the system*

Replenish essential nutrients to rebuild cellular reserves*

Fuel mitochondrial performance and healthy glutathione production*

Strengthen foundational resilience for long-term clinical outcomes*

WELLNESS CLUB

The NUTRAFi Wellness Club offers an exciting, passive income addition for qualiﬁed wellness partners and allows you to earn in 2 powerful ways:

CURRENT MODEL

Qualiﬁcations: Purchase a total of 250 sprays as a wholesale partner

In-person sales opportunities ONLINE & SOCIAL MEDIA with NUTRAFi’s done-for-you drop shipping platform TURN ENGAGEMENT INTO EARNINGS!

Unlock your portal: Receive access to your own back-ofﬁce dashboard with website link, unique QR code and real-time tracking system

WHOLESALE PARTNERS

• NUTRAFi products for 50%-75% margins

• Add to memberships, wellness programs and treatment packages

• Utilize sprays as add-ons or loyalty perks

ONLINE & SOCIAL MEDIA SALES

• Monetize your existing social media presence

• Use your link in bio & unique QR code. Perfect for: ✓reels ✓posts ✓stories ✓emails ✓website

• Powered by NUTRAFi’s done-for-you drop shipping platform MSRP $35 (single spray) / $99 (3-pack)

LivOn Labs

VIRUN

Booth #847

Booth #11104

VIRUN

1750 N. 8th St.

2654 W. Horizon Ridge Pkwy., Ste B5-108 Henderson, Nevada, 89052

United States

Colton, California, 92324

Ph: (412) 260-3906

United States

Email: service@livonlabs.com

Ph: (909) 618-3267

www .livonlabs .com

Email: nickols.huang@virun.com

www .virun .com

LivOn Labs made liposomal a thing when they introduced the first liposome-encapsulated dietary supplement in 2004. Operating on its stated mission to heal the world, LivOn Labs has since introduced more liposomal supplements that deliver time-tested, critical nutrients for absorption in the cells. Lypo-Spheric® Vitamin C, B Complex Plus, Glutathione, R-Alpha Lipoic Acid, and Magnesium are available in 80+ countries.

McArthur Insurance Agency, Inc.

Booth

#

VIRUN

12605 Ulmerton Rd.

Largo, Florida, 33774

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (800) 982-0398

Ph: (909) 618-3267

Email: ScottH@McArthuragency.com

Email: nickols.huang@virun.com

www .McArthurAgency .com

www .virun .com

McArthur Insurance Agency specializes in malpractice and risk management solutions for regenerative, longevity, anti-aging, integrative, and functional medicine practices nationwide. With over 30 years of experience and access to 35+ carriers, we understand the complexities of innovative and emerging therapies. Our team delivers customized, comprehensive coverage designed to protect modern medical practices as they evolve.

VIRUN

Longevity AI

Booth

#10

Booth #11104

VIRUN

2033 Gateway Place., Ste 420 San Jose, California, 95110

United States

1750 N. 8th St. Colton, California, 92324

Ph: (323) 649-9024

United States

Email: hadar.berkman@longevity-ai.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .longevity-ai .com

www .virun .com

Longevity AI is a clinical-grade AI platform that helps physicians deliver proactive, personalized longevity care, without adding to their workload. Our AI co-pilot, Florence, transforms complex lab, lifestyle, and wearable data into clear, evidencebased insights in seconds. By automating documentation and generating structured care plans, we help clinics save time, reduce administrative burden, and strengthen patient relationships. Proactive care. Smarter workflows. Better healthspan outcomes.

VIRUN

McGuff Company Inc. Booth #819

Booth #11104

VIRUN

1750 N. 8th St.

3524 West Lake Center Dr. Santa Ana, California, 92704

United States

Colton, California, 92324

Ph: (800) 854-7220

United States

Ph: (909) 618-3267

Email: answers@mcguff.com

www .mcguff .com

Email: nickols.huang@virun.com

www .virun .com

McGuff is the one-stop shop to grow your practice.

The McGuff Family of Companies includes: McGuff Medical, McGuff Pharmaceuticals and McGuff Outsourcing Solutions (503B). As a trusted family & veteran-owned business for over 50 years, we support practitioners with medical supplies, pharmaceuticals and 503B products. We proudly manufacture ASCOR®, the original FDA-Approved Ascorbic Acid Injection.

We prioritize quality, compliance and exceptional customer support. Our orders are processed on the same day and delivered free within 3 days.

VIRUN

MaxGen Labs

Booth #11104

Booth #931

VIRUN

1750 N. 8th St.

170 E Main St., Ste D Hendersonville, Tennessee, 37075

Colton, California, 92324

United States

Ph: (832) 683-1574

Ph: (909) 618-3267

Email: accounts@maxgenlabs.com www .maxgenlabs .com

Email: nickols.huang@virun.com www .virun .com

MaxGen Lab was created by practicing physicians to provide a safe, accurate, and easy-tounderstand way for people to learn about their bodies. Our reports are based on cutting-edge research, trusted by hundreds of physicians worldwide, and have received rave reviews and success stories.

All of our reports contain actionable steps with easy-to-understand and implement results. Our simple and precise DNA tests have helped thousands of individuals make more proactive choices toward optimal health and healing.

VIRUN

Medeia

Booth

#844

Booth #11104

VIRUN 1750 N. 8th St.

7 W. Figueroa St., Ste 215 Santa Barbara, California, 93101

Colton, California, 92324

United States

Ph: 18004334609

United States

Email: info@medeia.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

medeia .com

www .virun .com

Since its inception in 1992, Medeia, Inc. has been on the forefront in the manufacture and distribution of Neuro Diagnostic and Heart Rate Variability / ANS products. Medeia Inc specializes in the development of state of the art biometrical software and hardware products intended to monitor physiology for research and educational purposes.

VIRUN

Medivant Healthcare

VIRUN

MediVera Compounding Pharmacy

Booth #917

Booth #11104

158 S Kyrene Rd

VIRUN

1750 N. 8th St.

Chandler, Arizona, 85226

Colton, California, 92324

United States

Ph: (855) 784-4555

United States

Email: hrt@Medivanthealth.com

Ph: (909) 618-3267

www .medivanthealth .com

Email: nickols.huang@virun.com

www .virun .com

Medivant Healthcare (FDA registered), is a pioneer in the pharmaceutical industry, providing high quality products efficiently, reliably, affordably and at scale for hospitals and healthcare providers. Founded in 2015 and based in Phoenix, Arizona, Medivant Healthcare operates two fully automated CGMP FDA registered facilities, that produce Single Dose liquid injectable vials and pre-filled syringes.

Metagenics

VIRUN

25 Enterprise., Ste 200

1750 N. 8th St.

Aliso Viejo, California, 92656

United States

Colton, California, 92324

Ph: (800) 692-9400

United States

Ph: (909) 618-3267

Email: Info.customerservice@metagenics.com

Email: nickols.huang@virun.com

www .metagenics .com/en-us

www .virun .com

Metagenics is a science driven wellness brand rooted in over 40 years of clinical research and practitioner partnership. Trusted by healthcare professionals, Metagenics delivers precision crafted, professional grade supplements designed to work with the body and deliver results you can feel. Through clinically validated ingredients, transparent quality standards, and innovation across key health systems, Metagenics redefines supplements from guesswork to measurable outcomes.

Booth

#233

Booth #11104

5225 Crooks Rd.

VIRUN

Troy, Michigan, 48098

United States

1750 N. 8th St. Colton, California, 92324

Ph: (313) 433-6561

United States

Ph: (909) 618-3267

Email: Support@mediverarx.com

Email: nickols.huang@virun.com

mediverarx .com

www .virun .com

MediVera Compounding Pharmacy™ is a family-owned, PCAB-accredited 503A pharmacy with 25+ years of experience in personalized medicine. Located in a state-of-the-art 56,000 sq ft facility in Troy, Michigan, we serve providers nationwide across 45+ states. We specialize in customized medications for Hormone Replacement, Sexual Health, Weight Management, Longevity, Dermatology, and Veterinary needs. Our Impressed Advantage delivers streamlined prescribing, direct pharmacist consults, telehealth fulfillment, and dedicated support—so you can focus on patient care.

VIRUN

Melbourne Pharma

Booth #1032

Booth #11104

2235 S. Babcock St.

VIRUN

1750 N. 8th St.

Melbourne, Florida, 32901

Colton, California, 92324

United States

Ph: (833) 655-7500

Ph: (909) 618-3267

Email: info@melbournepharma.com www .melbournepharma .com

Email: nickols.huang@virun.com www .virun .com

Melbourne Pharma is a forward-thinking 503A compounding pharmacy specializing in dermatology, wellness, and chronic disease management. Our commitment to quality, service, innovation, and education shapes every patient and prescriber interaction. Providers benefit from streamlined ordering and innovative formulations produced in our state-of-the-art labs. Patients experience fast turnaround times, responsive support, and competitive pricing. Our specialized pharmacists actively participate in leading medical academies and provide ongoing education and training for both patients and healthcare professionals nationwide.

Microbiome Labs

VIRUN

Booth #417

Booth #11104

VIRUN

1750 N. 8th St.

77 Perry’s Chapel Church Rd. Franklinton, North Carolina, 27525

Colton, California, 92324

United States

Ph: (904) 940-2208

Ph: (909) 618-3267

Email: info@microbiomelabs.com

Email: nickols.huang@virun.com

www .microbiomelabs .com

www .virun .com

At Microbiome Labs (part of Novonesis Group), we are building a culture of pioneers. Those who are on the cutting-edge of products and protocols. Practitioners who value innovation but want to stand with a backbone of research-based science. Clinicians who want to stand beside us as we unlock the full potential of the human microbiome. We pioneer health by connecting the dots of the human biological system, so we can discover new solutions that revolutionize healthcare.

miraDry, Inc.

VIRUN

Booth #728

Booth #11104

100 Bayview Circle, Ste 360 Newport Beach, California, 92660

United States

VIRUN 1750 N. 8th St. Colton, California, 92324

Ph: (408) 579-8700

United States

Ph: (909) 618-3267

Email: marketing@miradry.com

miraDry .com

Email: nickols.huang@virun.com www .virun .com

miraDry is an innovative, FDA-cleared treatment that provides a long-lasting solution for excessive underarm sweat, odor and hair. Safe, immediate and non-surgical, miraDry effectively reduces sweat glands and hair follicles in the underarms, offering lasting results and 90% patient satisfaction. miraDry remains the first and only of its kind and is available globally, with more than 500,000 patients treated to date and growing. Learn more at miraDry.com.

VIRUN

Booth #11104

VIRUN

Mitozen Scientific

Booth

#334

Booth #11104

1014 NEast Ave

VIRUN

1750 N. 8th St.

Sarasota, Florida, 34237

United States

Colton, California, 92324

Ph: (941) 298-1138

United States

Email: 941-298-1138

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .mitozen .com

www .virun .com

MitoZen Scientific, founded by Dr. John Lieurance, is a nutraceutical company specializing in supplements that target mitochondrial health to unlock profound vitality and healing at the cellular level. Drawing from Dr. Lieurance’s expertise in detoxification, neurology, and natural healing, MitoZen targets root causes of ailments such as chronic fatigue, inflammation, sleep disorders, sinus issues, and post-COVID recovery. Some of our products include Lumetol Blue™ Bars, SandMan™ Suppositories, and Glutastat™ Nasal Spray for enhanced cellular rejuvenation, mitochondrial support, and gentle detox.

Myomar Molecular

56 Walford Rd.

1750 N. 8th St.

Sudbury, Ontario, P3E2H3

Canada

Colton, California, 92324

Ph: (902) 293-6349

United States

Email: support@myomarmolecular.com

Ph: (909) 618-3267

www .myomarmolecular .ca

Email: nickols.huang@virun.com

www .virun .com

Myomar Molecular is a biotech innovator revolutionizing the way we understand muscle health and function. We deliver the world’s first non-invasive, urine-based test that detects early muscle atrophy through precise biomarker analysis, providing personalized insights and actionable scores for clinicians, and patients. Empower proactive care, preserve strength, and transform lives—partner with Myomar today for cutting-edge muscle monitoring!

VIRUN

MyAdvice

Booth #11104

Booth #737

1850 West Ashton Blvd., Ste 500

VIRUN

Lehi, Utah, 84043

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (435) 575-7470

Ph: (909) 618-3267

Email: sales@myadvice.com

Email: nickols.huang@virun.com

myadvice .com

www .virun .com

MyAdvice helps businesses grow profitably with the Success Center, an AI-powered platform that unifies marketing, automation, and operations into one compounding system. It captures and qualifies leads 24/7, structures digital signals for modern search, and surfaces next best actions so teams move faster. Inside, Mya, your AI Growth Assistant, drives momentum with prompts, automations, and clear ROI. The result: more visibility, higher conversion, and revenue gains without tool sprawl. Show up. Stand out. Get chosen. Learn more at myadvice.com.

Mymycolab, LLC

VIRUN

Booth

#1112

Booth #11104

17849 Hunting Bow Circle., Ste 102

VIRUN

1750 N. 8th St.

Lutz, Florida, 33558

Colton, California, 92324

United States

Ph: (561) 631-3901

Ph: (909) 618-3267

Email: spenaranda@mymycolab.com

Mymycolab .com

Email: nickols.huang@virun.com www .virun .com

MyMycoLab is a laboratory specializing in blood serum antibody testing for mycotoxins. Our laboratory tests for 14 different mycotoxins for both IgG and IgE antibodies. This is the most precise and accurate method to determine if a person has been exposed to mycotoxins. Mycotoxins and molds have been called “The Great Masquerader” by the World Health Organization. This is because they imitate so many other illnesses and conditions that they are difficult to diagnose and treat.

VIRUN

Nano Genesis Labs

VIRUN

National Hair Loss Medical Aesthetics

Booth #344

Booth

#11104

VIRUN

8583 Irvine Center Dr., Ste 341

1750 N. 8th St.

Irvine, California, 92618

United States

Colton, California, 92324

Ph: (949) 506-7548

United States

Ph: (909) 618-3267

Email: info@nanogenesislabs.com

Email: nickols.huang@virun.com

www .nanogenesislabs .com

www .virun .com

Our mission is to elevate human performance at the cellular level. Born from a pursuit to solve inflammation, fatigue, and mental fog at their root, we engineered a breakthrough — the world’s most bioavailable, water-soluble Carbon 60. Inspired by the Nobel Prize–winning discovery of the C60 molecule, our team transformed it into a clean, potent, and clinically backed form the body can actually use. Every product we create is built on this foundation: science, purity, and results you can feel.

Booth

#227

#11104

VIRUN 1750 N. 8th St.

7000 E. Shea Blvd., Ste C-1580 Scottsdale, Arizona, 85254

Colton, California, 92324

United States

Ph: (602) 283-2355

Ph: (909) 618-3267

Email: info@nhlma.com

Email: nickols.huang@virun.com

www .nhlma .com

www .virun .com

National Hair Loss Company supports patients and professionals through medically focused, non-surgical hair loss solutions and advanced education. We specialize in hair replacement for medical alopecia, including chemotherapy, autoimmune disorders, and other clinical hair loss conditions. Our company also provides comprehensive medical alopecia training and certification courses for stylists, nurses, and clinicians, emphasizing scalp health, patient care, and evidence-based techniques to deliver natural, compassionate, and confident results.

Booth #1034

VIRUN

NewMind Neurofeedback

VIRUN

Next Generation Compounding Pharmacy

Booth #444

Booth #11104

VIRUN

9058 Main St., Ste 100

Woodstock, Georgia, 30188

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (847) 268-2879

United States

Email: sales@newmindtech.com

Ph: (909) 618-3267

newmind .tech

Email: nickols.huang@virun.com

www .virun .com

Unlock better outcomes with functional neurofeedback—a clear, practical approach that helps you understand the whole client rather than relying only on brainwave patterns. Expand your practice without expanding your space using our easy-to-use Home Training system, giving you the ability to deliver and monitor protocols in real time from anywhere. Get support for success with personalized training, guided mentoring, and a peer community that meets live three times each week to help you ramp up quickly and confidently.

Norsan, Inc.

444 Brickell Ave., #700

Miami, Florida, 33131

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (786) 690-0743

United States

Ph: (909) 618-3267

Email: info@norsan-health.com

www .norsan-health .com

Email: nickols.huang@virun.com

www .virun .com

NORSAN is Europe’s leading specialist in highdose Omega-3, dedicated to restoring fatty acid balance through science nature. Our Omega-3 Vegan line features 100% natural algae oil—never concentrated—delivering a potent 2,000 mg of EPA and DHA per dose. By sourcing directly from microalgae grown in controlled environments, we offer a sustainable, pollutant-free alternative to fish oil with a pleasant lemon taste and zero “fishy” aftertaste. Trusted by over 10,000 medical professionals, NORSAN bridges the gap between ethical living and clinical efficacy.

Booth

#241

Booth #11104

5448 Hwy. 11E

VIRUN

Piney Flats, Tennessee, 37686

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (866) 777-7476

Ph: (909) 618-3267

Email: pharmacystaff@ngcprx.com

Email: nickols.huang@virun.com

www .ngcprx .com

www .virun .com

At Next Generation, we specialize in customized medications tailored to individual patient needs— whether it’s specialized Weight loss products or patient specific medications. Every product is crafted with precision, care, and a commitment to quality that reflects our founders’ decades of combined experience.

Niagen Bioscience

VIRUN

Booth

#11104

#935

VIRUN

10900 Wilshire Blvd., Ste 600

1750 N. 8th St.

Los Angeles, California, 90024

Colton, California, 92324

United States

Ph: (949) 410-3984

United States

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: wholesale@Truniagen.com pro .truniagen .com

www .virun .com

Niagen Bioscience is the global leader in NAD+ research. Tru Niagen is backed by 40+ clinical studies and partnerships with Mayo Clinic, the NIH, Harvard, and Cambridge. Niagen Plus brings clinical-grade NAD+ IV therapy to wellness clinics nationwide. Recognized by the FDA, Health Canada, EFSA, and Australia’s TGA.

VIRUN

North

VIRUN

Novoxa Biotech ( Subsidiary of LeoCorps)

Booth #11104

Booth #1026

VIRUN

250 Stephenson Highway

1750 N. 8th St.

Troy, Michigan, 48083

United States

Colton, California, 92324

Ph: (847) 421-9515

United States

Ph: (909) 618-3267

Email: sales@north.com

Email: nickols.huang@virun.com

www .north .com

www .virun .com

Founded in 1992, North is a leading financial technology company building innovative, frictionless, end-to-end payment solutions for businesses of all sizes and industry types. North’s superior solutions span the entire payment ecosystem, from development, to partnerships that expand the landscape, creating a flexible universe that supports growth and scale for small businesses and merchants, as well larger enterprises with over $100 billion per year in electronic transaction volume.

Booth #11104

Booth #148

VIRUN

4623 West Nevso Dr. Las Vegas, Nevada, 89103

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (833) 536-7183

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: info@leocorps.oeg www .leocorps .org

www .virun .com

Novoxa Biotech subsidiary of LeoCorps is an ISO certified biotechnology and bioservices company with a focus on accelerating biomedical research and cell therapy by manufacturing, processing, and distributing high-quality, high purity and 3rd party tested human cellular and acellular products worldwide.

VIRUN

Booth #11104

VIRUN

Booth #926

NUTRAFi

Nuchido

VIRUN

Booth #341

Booth #11104

Dissington Hall

VIRUN

Dalton, England, NE180AD

1750 N. 8th St.

United Kingdom

Colton, California, 92324

Ph: (314) 260-7874

United States

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: partners@nuchido.com nuchido .com

www .virun .com

Nuchido translates the latest breakthroughs in aging science into advanced solutions that restore cellular health and reverse biological age. Founded by longevity expert Dr. Nichola Conlon, our flagship product Nuchido TIME+, is a nextgeneration NAD+ boosting supplement. Using a systems-based approach, our formulation goes beyond single-ingredient products to address the root causes of NAD+ decline. Nuchido integrates into clinical longevity protocols to support your patients’ cellular health.

NutriDyn

431

5414 Hwy.12

VIRUN

Maple Plain, Minnesota, 55359

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (800) 444-9998

United States

Email: info@nutridyn.com

Ph: (909) 618-3267

NutriDyn .com

Email: nickols.huang@virun.com

www .virun .com

NutriDyn is a practitioner-exclusive nutraceutical company serving licensed healthcare professionals since 1973. Family-owned and operated, we formulate and manufacture GMPcertified, third-party tested supplements designed for clinical performance and measurable patient outcomes. Our products are available only through qualified practitioners, preserving clinical integrity and supporting functional medicine with science-driven formulations that prioritize quality, transparency, and results.

VIRUN

NuMedica

Booth #11104

Booth #634

VIRUN

9503 E. 55th Place

1750 N. 8th St.

Tulsa, Oklahoma, 74145

United States

Colton, California, 92324

Ph: (800) 869-8100

United States

Email: mail@numedica.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .numedica .com

www .virun .com

NuMedica® is an NSF® GMP Certified, FDA registered company dedicated to advancing clinical nutrition and serving healthcare professionals with the highest quality, cuttingedge formulas. Our formulas are designed with active ingredients for higher performance along with advanced nutrient delivery methods and Enhanced Absorption Technologies™ offering value through increased bioavailability. We are committed to the quality, safety and performance of our formulas.

VIRUN

NUTRAFi

Booth #1031

Booth #11104

12144 US 301 N., #409

VIRUN

1750 N. 8th St.

Parrish, Florida, 34219

Colton, California, 92324

United States

Ph: (941) 920-1011

Ph: (909) 618-3267

Email: inquiries@nutrafi.com

Email: nickols.huang@virun.com

www .nutrafi .com

www .virun .com

NUTRAFi® is a category-leading wellness brand delivering premium oral spray supplements through an innovative, partner-driven model. Designed for today’s health-conscious consumer, NUTRAFi combines science-backed formulations, advanced absorption technology, and scalable programs for wellness, hospitality, and travel partners. Our mission is simple: elevate wellness experiences while creating powerful growth opportunities worldwide.

VIRUN

Olympia Pharmaceuticals

#11104

VIRUN

6700 Conroy Road., Ste 155

1750 N. 8th St.

Orlando, Florida, 32835

Colton, California, 92324

United States

Ph: (407) 673-2222

United States

Ph: (909) 618-3267

Email: inquiries@olympiapharmacy.com

Email: nickols.huang@virun.com

www .olympiapharmacy .com

www .virun .com

Olympia Pharmaceuticals is an FDA-registered 503(B) outsourcing facility based out of Orlando, Florida. The facility serves 49 states nationwide across a wide range of industries, including Longevity, Weight Management, Sexual Health, Wellness, Immunity, and Nutrition. In 2025, Olympia launched its sister brand and third location, Wesley Pharmaceuticals. This stateof-the-art 503(B) facility was designed to help optimize production and meet the growing demand of providers across the nation.

VIRUN

Optimal Balance Pharmacy

Booth #11104

Booth #1144

2204 FM 1960 W., Ste F

Houston, Texas, 77090

VIRUN 1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (832) 904-5327

Ph: (909) 618-3267

Email: events@obprx.com

Email: nickols.huang@virun.com

OBPrx .com

www .virun .com

503a Compounding pharmacy. We provide peptides, GLP-1’s, hormones and vitamins.

Age well with Methyl-Action*

Fueling normal methylation processes is important for healthy aging at the cellular level.*

Methyl-Action is formulated to support essential methylation with B-vitamins in their active forms * Healthy methylation is vital for normal homocysteine metabolism.* Maintaining normal homocysteine levels promotes neurological, cardiovascular, eye, and bone health *

Methylation Support

B-2 and B-6 are essential f or the activation of folate into 5-methyltetrahydrofolate *

Homocysteine Regulation*

Betaine, a methyl donor, and B-12 are critical for the recycling of harmful homocysteine into methionine.*

Hypromellose

**MTHF = Methyltetrahydrofolate

In amber glass bottle to preserve freshness UNIQUE FORMULA!

NEW FORMUL AS BOOTH 901

VIRUN

OrganoLeaf

Booth #440

Booth #11104

1720 Diplomacy Row

VIRUN

Orlando, Florida, 32809

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (407) 730-4137

Ph: (909) 618-3267

Email: info@organoleaf.com

organoleafwholesale .com

Email: nickols.huang@virun.com

www .virun .com

We are NSF and GMP certified contract manufacturer and also operate our own brand, primarily serving practitioners and practitionerfocused brands. We specialize in producing highquality, sugar-free gummies made with allulose, monk fruit, or other accepted natural sweeteners, using pectin. Quality is our top priority, and all products are fully lab tested, which is why practitioners trust our manufacturing and brand.

Ortho Molecular Products

VIRUN

Booth #221

Booth #11104

28160 W. Northwest Hwy., Ste 100

VIRUN

Barrington, Illinois, 60010

United States

1750 N. 8th St. Colton, California, 92324

Ph: (815) 206-6586

United States

Email: l.grendel@ompimail.com

Ph: (909) 618-3267

www .orthomolecularproducts .com

Email: nickols.huang@virun.com

www .virun .com

For over 30 years, Ortho Molecular Products has partnered exclusively with health care providers to deliver nutritional solutions of the highest efficacy. The most trusted voices in health care put their trust in our products to help patients get better, faster. Our commitment to science, careful raw ingredient selection, and strict quality standards goes into every supplement we formulate. To learn more, visit www.orthomolecularproducts.com or call 1-800-332-2351.

VIRUN

Oxygen Health Systems

Booth #11104

Booth #30

6810 Route 53

Woodbridge, Illinois, 60517

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (630) 812-7865

Ph: (909) 618-3267

Email: sales@OxygenHealthSystems.com

Email: nickols.huang@virun.com

www .oxygenhealthsystems .com

www .virun .com

Founded in 2016, our Chicagoland-based hyperbaric company is backed by 120+ years of engineering and manufacturing expertise from global innovators, including AT&T, Bell Labs, HP, Nokia, Samsung, and AbbVie. Of 40+ available chamber models, more than 25 are showcased in our stunning showroom—the largest in the nation. Trusted by the NY Yankees, NY Giants, and elite institutions worldwide, we deliver globally with direct engineer access and 150+ five-star reviews, defining luxury hyperbaric excellence at competitive prices.

Path Peptides LLC

VIRUN

Booth #11104

PD Labs

VIRUN

Booth #337

10719 Norwalk Blvd

VIRUN

1750 N. 8th St.

Santa Fe Springs, California, 90670

United States

Colton, California, 92324

United States

Ph: (562) 906-8888

Email: info@oxyhealth.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .oxyhealth .com

www .virun .com

OxyHealth has forever changed the way the medical industry practices hyperbaric therapy. Since our inception, we are devoted to providing quality and brilliantly safe portable hyperbaric chambers to physicians, professional athletes, wellness centers, and families. All OxyHealth chambers are designed for patients to easily selftreat, which has fostered a cutting-edge trend in hyperbaric technology.

VIRUN

7244 SW 42 Terr

1750 N. 8th St.

Miami, Florida, 33155

Colton, California, 92324

United States

Ph: (305) 710-5799

Ph: (909) 618-3267

Email: info@pathpeptides.com

Email: nickols.huang@virun.com

pathpeptides .com

www .virun .com

Path Peptides is a B2B peptide distribution platform serving licensed physicians, clinics, and medical practices across the United States. We provide batch-verified products supported by third-party Certificates of Analysis. Our infrastructure enables scalable ordering, account-level pricing, and transparency to support clinical practices integrating peptides. Path partners with medical professionals seeking reliable sourcing, quality assurance, and operational consistency.

1750 N. 8th St.

1513 East New Hope Dr., Bldg E Cedar Park, Texas, 78641

Colton, California, 92324

United States

Ph: (512) 219-0724

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: info@pdlabsrx.com pdlabsrx .com

www .virun .com

PD Labs is a nationally licensed compounding pharmacy and your trusted partner in advanced formulations for Lyme, Mold/CIRS, hormonal and thyroid health, cognitive support, peptide therapies, and men’s and women’s care. With proprietary LPT technology and personalized service, we support complex protocols with precision and dependable turnaround. Dedicated to innovation, excellence, and community wellbeing, we proudly ship nationwide. Discover the difference with PD Labs.

VIRUN

Booth #11104

VIRUN

Physicians Lab

Booth #730

Booth #11104

VIRUN

1750 N. 8th St.

4850 T Rex Ave., Ste 150 Boca Raton, Florida, 33431

United States

Colton, California, 92324

Ph: (877) 326-5969

United States

Email: info@physicianslab.com

Ph: (909) 618-3267

physicianslab .com

Email: nickols.huang@virun.com

www .virun .com

We provide state-of-the-art science to a growing number of physicians focused on integrative medicine and wellness for an aging population. We provide superior solutions to practices and patients who are actively seeking to manage their health through innovations in technology and preventive medicine. Physicians Lab delivers precise and reliable results while providing the tools necessary to complete convenient, affordable, and timely lab testing.

VIRUN

PNOE, Inc.

Booth #319

Booth #11104

67 Maplewood St.

VIRUN

1750 N. 8th St.

Malden, Massachusetts, 2148

United States

Colton, California, 92324

Ph: (650) 670-4450

United States

Email: info@pnoe.com

Ph: (909) 618-3267

pnoe .com

Email: nickols.huang@virun.com

www .virun .com

PNOĒ is a breakthrough in health and fitness, making breath analysis, a key tool for understanding metabolism, fitness levels, and overall health, easily accessible to health professionals. Along with its special software and expert team support, PNOĒ helps health experts give personalized advice on diet, workout, and lifestyle. It simplifies identifying health issues and offers custom recommendations.

VIRUN

Power2Practice

Booth #1115

Booth #11104

VIRUN

1750 N. 8th St.

601 S. Saginaw St., 5th Fl Flint, Michigan, 48502

Colton, California, 92324

United States

Ph: (855) 934-1764

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: sales@power2practice.com power2practice .com

www .virun .com

Power2Practice (P2P) is an all-in-one, cloudbased EMR and practice management platform built specifically for functional, integrative, and concierge healthcare clinics. It streamlines scheduling, charting, labs, billing, and patient communication—helping teams reduce admin time, improve workflow efficiency, and deliver a better patient experience.

This year, we’re also launching P2Pai, our nextgeneration evolution of P2P; designed to bring smarter, faster workflows and AI-enabled support to the clinical and administrative experience.

PQ Pharmacy

Booth #330

VIRUN Booth #11104

VIRUN

15215 Technology Drive

1750 N. 8th St.

Brooksville, Florida, 34604

Colton, California, 92324

United States

Ph: (888) 933-9073

Ph: (909) 618-3267

Email: info@pqpharmacy.com

Email: nickols.huang@virun.com

www .pqpharmacy .com

www .virun .com

Located in Brooksville, Florida, PQ Pharmacy is a USP 800 and CGMP compliant FDA-Registered 503B Outsourcing Facility. We provide highquality sterile compounded products in bulk to qualified healthcare facilities. The quality assurance program at our 12,000 square-foot facility encompasses compliance with FDA regulations, CGMP standards, and a robust environmental monitoring program. We take pride in going above and beyond industry standard. All batches of medication are tested by an independent lab for multiple standards such as sterility and potency.

VIRUN

Precision Point Diagnostics

Booth #11104

Booth #908

VIRUN

9 Dunwoody Park., Ste 122

1750 N. 8th St.

Dunwoody, Georgia, 30338

Colton, California, 92324

United States

Ph: (678) 736-6374

United States

Email: info@precisionpointdiagnostics.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

www .precisionpointdiagnostics .com

www .virun .com

Precision Point Diagnostics is an innovator of testing solutions that assist in the diagnosis and management of conditions commonly addressed by Functional Medicine. The Gut Ox Stress Test measures key biomarkers that reveal how well the gut, immune system, and detoxification pathways are functioning. Our NEW Advanced Food Sensitivity test has been updated: more foods, IgA, IgG1-3 ( not total), Zonulin and more. Our founders, Dr. Burdette and Dr. Agolli, will be at the booth to review all testing advancements.

VIRUN

PRENUVO

Booth #128

Booth

#11104

550 Biltmore Way., Ste 118

Coral Gables, Florida, 33134

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (833) 544-1281

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: practioners@prenuvo.com www .prenuvo .com

www .virun .com

Prenuvo delivers a comprehensive, radiation-free whole-body MRI designed for early detection and proactive health management. Its standardized protocol screens for hundreds of conditions in a single, comfortable session, giving patients a clear, actionable view of their health. With concierge-level care, fast results, and clinically rigorous imaging, Prenuvo empowers people to catch issues earlier, make informed decisions, and take control of their long-term well-being through advanced, preventive diagnostics.

Unlock the Secret to Healthy Aging

by nicotinamide riboside, Longevity Essentials NAD+ helps support the cellular foundation of your patients’ energy, clarity, and long-term metabolic health.*

As NAD+ drops with age, so does your capacity to keep up.

Longevity Essentials NAD+, featuring nicotinamide riboside, helps restore your energy so you can stay sharp and ready for the people and activities you care about.* This powerful formula helps support the clarity, energy, and resilience you rely on today and in the years to come.*

Prime Health Solutions

VIRUN

Booth #732

Booth #11104

1016 Michigan Blvd.

VIRUN

Dunedin, Florida, 34698

1750 N. 8th St.

United States

Colton, California, 92324

Ph: (912) 571-4323

United States

Email: primehealthsol@gmail.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

primehealthsolutionsUSA .com

www .virun .com

Prime Health Solutions is a national practice operations consultant and distributor of specialty products and services designed to advance clinical services and financial performance. Together with our partners and suppliers, we work to provide innovative life-changing products and therapies for providers across the country.

Pure Encapsulations

490 Boston Post Rd.

1750 N. 8th St.

Sudbury, Massachusetts, 1776

United States

Colton, California, 92324

Ph: (800) 753-2277

United States

Ph: (909) 618-3267

Email: customerservice@PureEncapsulations.com www .pureencapsulationspro .com

Email: nickols.huang@virun.com www .virun .com

At Pure Encapsulations®, we know it’s what’s inside that counts. That’s why we’ve spent the last 30 years researching, innovating, and developing our comprehensive line of premium supplements, to bring you over 400 uniquely formulated products made with high-quality, pure ingredients backed by verifiable science to complement your plan of care. Everything your patients need and nothing they don’t—that’s goodness encapsulated.

VIRUN

Professional Health Products

Booth #11104

Booth #927

VIRUN

2104 Babcock Blvd.

Pittsburgh, Pennsylvania, 15209

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (412) 760-1115

Ph: (909) 618-3267

Email: hlord@phpltd.com

Email: nickols.huang@virun.com

www .phpltd .com

www .virun .com

Cutting corners when it comes to quality is an all too common practice in the supplement industry. We at PHP® have been committed to using the highest quality ingredients, backed by science, in our formulations since our beginning in 1978. Our integrity and ingenuity goes into every product in our comprehensive line; making the partnership we have with clinicians above industry standard.

Protocol For Life Balance

VIRUN

Booth #646

Booth #11104

244 Knollwood Drive

VIRUN

1750 N. 8th St.

Bloomingdale, Illinois, 60108

Colton, California, 92324

United States

Ph: (877) 776-8610

Ph: (909) 618-3267

Email: sales@protocolforlife.com

Email: nickols.huang@virun.com

www .protocolforlife .com

www .virun .com

Protocol For Life Balance is a well-researched, potent, and efficacious brand of high-quality dietary supplements and natural products sold exclusively through licensed healthcare practitioners. Protocol For Life Balance offers many unique formulas and products, that come with a money -back guarantee if any patient is less than 100% satisfied. Our mission is simply to provide quality products that lead to healthy patients and satisfied physicians. Family Owned and Operated.

Purepell

VIRUN

Booth

#430

VIRUN

Booth #1111

5 Cowboys Way., Ste 300

Frisco, Texas, 75034

VIRUN 1750 N. 8th St.

Colton, California, 92324

United States

Ph: (469) 277-7580

Ph: (909) 618-3267

Email: sales@purepell.com

Email: nickols.huang@virun.com

www .purepell .com

www .virun .com

Purepell is a turnkey Bioidentical Hormone Replacement Therapy solution for medical practices. We equip providers with clinical training, ongoing support, and proven marketing systems to integrate BHRT with confidence. Patients benefit from safe, consistent hormone optimization delivered by certified professionals. Purepell connects patients with trained providers and helps practices grow while elevating care standards. Our mission is simple: help patients feel younger and live better through evidencebased hormone therapy for sustainable practice growth and long-term patient trust and clinical excellence.

VIRUN

3600 FAU Blvd., Ste 101

Boca Raton, Florida, 33431

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (561) 368-1880

United States

Ph: (909) 618-3267

Email: ebo2sales@purxcell.com purxcell .com

Email: nickols.huang@virun.com www .virun .com

PURXCELL trains clinics worldwide to implement EBO2 (Extracorporeal Blood Oxygenation & Ozonation), an advanced regenerative protocol designed to enhance oxygenation, immune modulation, and patient recovery. Led by Dr. Joseph Purita, board-certified orthopedic surgeon and regenerative medicine pioneer, PURXCELL provides hands-on physician training, clinical protocols, and integration support to help practices deliver better outcomes through nextlevel regenerative care.

Booth #11104

Push Patch

VIRUN

Booth #901

Booth #11104

VIRUN

1750 N. 8th St.

3683 Garden Court Grove City, Ohio, 43123

United States

Colton, California, 92324

Ph: (951) 840-8769

United States

Email: orders@pushpatch.com

Ph: (909) 618-3267

www .pushpatch .com

Email: nickols.huang@virun.com

www .virun .com

Push Patch employs iontophoresis, utilizing minimal electrical charges to transmit medication through the skin-absolutely pain-free. Think of it as a magnet-like operation, but with two electrodes instead or magnets. Applying the patch initiates a charge, propelling the medication through your skin and directly into your bloodstream. This is advantageous as it evades the gastrointestinal system, where medication is often compromised.

Quality Aesthetics

VIRUN

6396 McLeod Dr., Ste 1

Las Vegas, Nevada, 89120

1750 N. 8th St.

United States

Colton, California, 92324

United States

Ph: (702) 483-1446

Email: info@quality-aesthetics.com

Ph: (909) 618-3267

Email: nickols.huang@virun.com

quality-aesthetics .com

www .virun .com

We are a premier B2B provider of aesthetics consumables and equipment, founded by healthcare industry veterans with decades of combined experience. Our leadership team brings deep expertise from Clinical Diagnostic Labs, Compounding Pharmacies, and other vertically integrated healthcare solutions, positioning us uniquely to serve the evolving needs of aesthetic practices nationwide

VIRUN

Qualia Life Sciences

Booth #11104

Booth #534

VIRUN

2011 Palomar Airport Rd., Ste 101 PBM 160

1750 N. 8th St.

Carlsbad, California, 92011

United States

Colton, California, 92324

Ph: (855) 281-2328

United States

Ph: (909) 618-3267

Email: practitioner@qualialife.com

Email: nickols.huang@virun.com

www .qualialife .com

www .virun .com

Qualia Life Sciences was established in 2015. Their products aim to change the way people age through pioneering standards that include human studies on every formula prior to release. Their expanding product lineup includes support for brain health, cellular health, NAD+levels, magnesium, and the recently released Qualia Stem Cell.

VIRUN

Qualiphy PC

Booth #11104

Booth #545

113 N. San Vicente Blvd, 3rd Floor

VIRUN

Beverly Hills, California, 90211

United States

1750 N. 8th St. Colton, California, 92324

United States

Ph: (213) 285-0233

Ph: (909) 618-3267

Email: nickols.huang@virun.com

Email: sales@qualiphy.me qualiphy .me

www .virun .com

Qualiphy delivers whitle-label telehealth consultations on behalf of medical practices across the nation. We enable white-label medical clearances, prescription fulfillment for peptides, urgent care and wellness treatments. Consultations are available via synchronous (livevideo) or asynchronous (form-based) formats, on-demand with no scheduling required. With transparent, pay-per-use pricing and no monthly fees, Qualiphy supports seamless API integrations, and real-time results tracking. Available 7 days a week, 365 days a year, from 6am-7pm PST. Qualiphy empowers practices to scale compliant care—instantly and nationwide

Quicksilver Scientific

VIRUN

1960 Cherry St

Louisville, Colorado, 80027

1750 N. 8th St.

Colton, California, 92324

United States

Ph: (303) 531-0861

Ph: (909) 618-3267

Email: support@quicksilverscientific.com

Email: nickols.huang@virun.com

www .quicksilverscientific .com

www .virun .com

Quicksilver Scientific® is a leading manufacturer of advanced nutritional systems with a focus on detoxification. We specialize in superior liposomal delivery systems and heavy metal testing to support optimal health. Our advanced liposomal supplements are highly absorbable and support the body in the elimination of the broad range of toxins we’re exposed to. We are passionate about health and well-being and are committed to improving the lives of everyone we touch.

VIRUN

Regenative Labs

Booth #50

Booth #11104

VIRUN

1700 West Main St., Ste 500

1750 N. 8th St.

Pensacola, Florida, 32502

Colton, California, 92324

United States

Ph: (800) 891-3452

Ph: (909) 618-3267

Email: info@regenativelabs.com www .regenativelabs .com

Email: nickols.huang@virun.com www .virun .com

Regenative Labs is a human tissue allograft manufacturer specializing in birth tissue (amniotic membrane, umbilical cord).

Booth #11104

VIRUN

Booth #807

Rejuvatide

Regenerative Research Group

Booth

#446

1912 Capital Ave., Ste 500 Cheyenne, Wyoming, 82001

United States

Ph: (720) 459-6229

Email: info@rrg.bio

rrg .bio

Regenerative Research Group, based out of Utah, is a biologics supply and implementation support company serving medical clinics. We provide perinatal tissue based products along with training, compliance guidance, and operational support to help practices responsibly integrate regenerative service lines. Our team focuses on proper handling, education, and clinic infrastructure so providers can expand treatment options while maintaining regulatory awareness and patient centered care.

Rejuvatide Peptides

Booth

#1103

784 US Highway 1 Unit 12

North Palm Beach, Florida, 33408

United States

Ph: (877) 890-7678

Email: Hello@RejuvatidePeptides.com

www .rejuvatidepeptides .com

Rejuvatide Peptides; domestic manufactures of bio-identical research peptide compounds with over 99% purity. Direct research use (retail), wholesale, private label and affiliate links available for qualified accounts.

Rejuvenation Technologies Inc.

Booth

#842

415 Clyde Ave., Ste 107 Mountain View, California, 94043

United States

Ph: (669) 321-5238

Email: info@rejuvenationtech.com

rejuvenationtech .com/

Rejuvenation is pioneering advanced technologies to rewind cellular mechanisms of aging, including therapeutic telomere extension. Short telomeres are now recognized as a fundamental cause of aging-related diseases, including pulmonary fibrosis, liver disease, and bone marrow failure. Our breakthrough technology can safely lengthen telomeres in specific cells, potentially reversing cellular aging and preventing or treating diseases and conditions caused by short telomeres.

solutions for life

Researched Nutritionals

Booth #527

PO Box 224

Los Olivos, California, 93441

United States

Ph: (805) 693-1802

Email: customerservice@researchednutritionals. com

www .researchednutritionals .com

Researched Nutritionals® is passionate about research because we know facts make all the difference. This is why we publish peer-reviewed clinical research on our industry-leading formulations. With products focused on key areas of health such as mitochondrial function, immune support, detoxification, and cytokine health, Researched Nutritionals® is a leader within the practitioner-exclusive dietary supplement market and is dedicated to working directly with healthcare practitioners for their most challenging patient needs.

3330 Chastain Meadows., Ste 101

Kennesaw, Georgia, 30144

United States

Ph: (678) 549-0728

Email: sales@revelationpharma.com

revelationpharma .com

Revelation Pharma is a national network of 503A and 503B compounding pharmacies providing innovative and quality pharmacy preparations and services through “industry best” patient care and solutions for customers.

1501 S 8th Street

Las Vegas, Nevada, 89401

United States

Ph: (205) 821-8068

Email: sales@reverrahealth.com www .reverrahealth .com

Reverra is a modern health and wellness company built on expertise, not hype. In a crowded market of trends and underwhelming products, we raise the standard through clinical-grade compounds and fast-acting oral strip delivery systems designed for efficient peptide absorption. Backed by decades of experience in healthcare, pharmacy, and peptide distribution, we’ve supported thousands of doctors and clinics in implementing proven protocols — and are now making those same trusted tools accessible to everyone.

Revelation Pharma Booth #147

Reverra Booth #1147

By Power2Practice®

Ai-Powered Practice Management for Functional and Integrative Medicine

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TASK MANAGEMENT DASHBOARD AI POWERED SCRIBING, VISIT SUMMARIES, LAB PRESCRIPTION ORDERING, AND SCHEDULING

SYSTEMS HEALTH MATRIX

SECURED INTERNAL MESSAGING

CUSTOM FORMS BUILDER WITH PATIENT PORTAL INTEGRATION

CLINICAL CHARTING & SOAP NOTES

ReviveRX

Booth #1007

3831 Golf Dr.

Houston, Texas, 77018

United States

Ph: (888) 689-2271

Email: info@reviverxpharmacy.com reviverx .com

ReviveRX is a leading licensed mail-order pharmacy specializing in commercially available and compounded medications. Our compounds are expertly crafted in USP-certified clean rooms at our Houston headquarters, ensuring the highest quality standards. We work closely with best-in-class pharmacists, scientists, healthcare providers, and pharmaceutical manufacturers to provide high-quality, dependable products to our patients and clinic partners.

RGCC North America

Booth

#102

8354 Northfield Blvd., Ste 3700

Denver, Colorado, 80238

United States

Ph: (720) 647-2424

Email: events@rgcc-international-northamerica. com

myrgcc .com

At RGCC North America, we are deeply committed to advancing personalized cancer care within the integrative oncology space. Our mission is to empower individuals facing cancer with tailored insights that can transform their journey. We are also passionate about engaging with the oncology community to share our work and foster meaningful discussions around innovative approaches in the field.

RHO Nutrition

Booth

#642

100 Brickell Ave., Ste 715 #1123

Miami, Florida, 33131

United States

Ph: (754) 231-3542

Email: support@rhonutrition.com

www .rhonutrition .com

Rho Nutrution is a next-generation liquid vitamin therapy brand built on one core belief: absorption matters. While most supplements come as pills or powders, Rho uses liposomal delivery—nutrients encapsulated in phospholipids—to help protect ingredients through digestion and support effective cellular use. Our formulas are developed by biotech experts, manufactured in a cGMPcertified, FDA-registered U.S. facility, and thirdparty tested for purity and potency. Rho focuses on smarter delivery, clinically studied ingredients, and daily consistency.

Rush Pharmacy

1977 Alafaya Trail., Ste 112 Oviedo, Florida, 32765

United States

Ph: (407) 205-7336

Email: sales@rushpharmacy.com www .rushpharmacy .com

Rush Pharmacy is a nationally licensed compounding pharmacy focused on quality, compliance, and patient-centered care. With expertise in sterile and non-sterile compounding, Rush partners with clinics and providers to deliver customized therapies backed by rigorous testing, responsive service, and fast nationwide shipping. Our team is committed to innovative and reliable solutions that support better outcomes for patients and practices alike.

Rx Harmony

Booth #110

45 Technology Pky. S, Ste 225

Peachtree Corners, Georgia, 30092

United States

Ph: (770) 800-3585 x130

Email: clinicalsupport@thejoigroup.com

www .rx-harmony .com

RxHarmony is a managed healthcare services partner that turns integrative and wellness practices into predictable recurring revenue engines while improving patient outcomes. Acting as an extension of your team, we deliver concierge prescription management, personalized medication programs, and ongoing patient education and support—reducing practitioner effort, increasing engagement, and maximizing profitability. Integrate evidence-based programs without adding to your schedule, and restore the joy of practicing medicine.

Sanoviv Medical Institute

Booth #120

Km 39 carr libre Tijuana-Ensenada Playas De Rosarito, Baja California, 22712

Mexico

Ph: (385) 695-2328

Email: www.sanoviv.com www .sanoviv .com

Sanoviv Medical institute is a fully-licensed integrative hospital, located in beautiful Rosarito Beach, Mexico, just south of San Diego. Our whole-body approach focuses on getting to the root cause of illness, not just treating symptoms, while immersing each guest in a healing environment. Due to our location, we can offer treatments that are not available in the US or other areas. Sanoviv is the perfect solution for integrative patients who are not progressing or who need advanced in-patient care.

Booth #101

Science Lab 3 Inc.

Booth #540

6619 S Dixie Hwy

Miami, Florida, 33143

United States

Ph: (305) 989-4139

Email: info@memoryair.com

www .memoryair .com

Science Lab 3 is a neuroscience-driven longevity company advancing cognitive health through non-invasive sensory innovation. Its flagship technology, Memory Air, delivers clinically studied olfactory stimulation during sleep to support memory, mood, and brain resilience—without drugs or behavioral burden. In peer-reviewed research, nightly olfactory enrichment demonstrated a 226% improvement in memory performance. Science Lab 3 partners with physicians and care leaders to bring scalable, evidence-based brain enrichment into clinical and at-home settings.

seca

Booth #513

1439 Stuart Engals Blvd., Ste 200 Mount Pleasant, South Carolina, 29464

United States

Ph: (800) 542-7322

Email: info.us@seca.com

www .secambca .com

seca is a global HealthTech leader redefining medical-grade measurement. Founded in 1840, seca delivers clinically validated body composition solutions for functional and longevity practices. With MRI-validated accuracy and research-backed credibility, seca transforms Medical Biometric Data into defensible treatment guidance through integrated hardware and Analytics 125 software. More than results, seca provides an ecosystem with AI Health Insights and Treatment Tracker functionality that strengthens clinical confidence, streamlines workflows, and supports measurable, individualized longevity care.

SFI Health

Booth #1136

795 Trademark Dr. Reno, Nevada, 89521

United States

Ph: (775) 850-8800

Email: customerserviceusa@sfihealth.com us .sfihealth .com

At SFI Health®, we’re shaping the future of natural healthcare through science-driven innovation and a legacy rooted in microbiome excellence. Our journey began in 1969 with Klaire Labs® founder Clair Farr, a pioneer in clean, hypoallergenic formulations long before gut health was mainstream. Today, we build on that foundation with advanced microbiome and cognitive health solutions—empowering healthcare professionals to support mental clarity, focus, mood, and better patient outcomes.

SigmaMD

Booth #945

1200 Riverside Dr., #1265

Reno, Nevada, 89503

United States

Ph: (956) 332-3030

Email: contact@sigmamd.com sigmamd .com

SigmaMD is an all-in-one care management platform for modern clinics. We combine a powerful EHR, retail membership and employer plan management, payments, patient and clinician apps, and built-in communication tools while integrating AI directly into clinical and operational workflows. SigmaMD supports operational and clinical scale from individual practices to employer-backed care models while keeping the focus on patient care.

SensIQ Nootropics & Adaptogens

Booth #1045

61 W. Palisade Ave. Englewood, New Jersey, 7631

United States

Ph: +1 (305) 921-0537

Email: hello@sensiqnootropics.com sensiqnootropics .com

At SensIQ, our mission is to enhance cognitive wellness with safe, evidence-based formulations that support the brain’s natural pathways for focus, memory, sleep, and stress resilience. Every product is doctor-designed, non-hormonal, and rooted in clinical research to deliver meaningful support for everyday cognitive performance. Trusted by thousands of healthcare practitioners, we’re committed to transparency, quality, and scientific integrity. Our goal is simple: to make advanced, neurologist-formulated supplements accessible to anyone seeking clearer thinking, calmer days, and long-term brain health.

SilverCeuticals Inc.

Booth #726

1396 W. 200 South., Ste 2C Lindon, Utah, 84042

United States

Ph: (385) 212-4044

Email: sales@silverceuticals.com www .silverceuticals .com

SilverCeuticals features cutting-edge Ag4O4 nano-silver technology, engineered for superior bioavailability and efficacy compared to traditional silver particles (according to 3rd party testing). Our professional-grade lineup includes advanced wound care, immune support, oral health, and anti-aging aesthetics designed for clinical results. By targeting cellular health and tissue rejuvenation, we provide practitioners with innovative, non-toxic solutions to enhance patient outcomes. Discover how our multivalent silver molecule technology is redefining restorative medicine and graceful aging. Experience SaferSilver™.

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SKIN|ATP

Booth #947

3315 Industrial Pkwy.

Jeffersonville, Indiana, 47130

United States

Ph: (812) 920-0596

Email: customercare@skinatp.com

www .skinatp .com

Ageless beauty starts at the cellular level and cell energy is the key. Healthy skin is powered by adenosine triphosphate (ATP) and is the energy source behind every cellular function. ATP fuels collagen and elastin production, cellular repair, hydration and renewal. As we age, skin ATP levels decrease leading to visible changes in skin texture. ATPv, is a scientific breakthrough technology clinically proven to deliver ATP to skin cells.

Sofwave

Booth #131

1211 Puerto Del Sol., Ste 200 San Clemente, California, 92673

United States

Ph: (855) 763-9283

Email: tricia.smith@sofwave.com

www .sofwave .com

Sofwave is an innovative medical aesthetics company specializing in non-invasive skin solutions for total body regenerative medicine.

STATÜR Skin Solutions

Booth #343

2156 W. Northwest Hwy., Ste 305 Dallas, Texas, 75220

United States

Ph: (702) 704-0101

Email: amanda@staturskin.com

staturskin .com

European inspiration, American innovation. Simplified skincare designed for skin longevity. Fewer steps, better results.Our promise is to develop science forward formulas that are better than the best products on the market, offer them for a better price and deliver results through a simplified approach designed for consistency. Advanced formulas plus consistent use creates lasting results. Instead of creating a single product for each issue, our formulas combine multiple scienceforward activities to address a range of concerns in one product.

Strive Pharmacy

Booth #501

1275 E. Baseline Rd., Ste 104

Gilbert, Arizona, 85233

United States

Ph: (480) 660-4566

Email: Info@strivepharmacy.com www .strivepharmacy .com

STRIVING SINCE 2018 | We Take Medicine Personally

Strive is more than a compounding pharmacy; we’re on a mission to redefine the standard of personal wellness. We reject the one-size-fits-all approach to medicine because we believe more options lead to better outcomes. From support for hormones and weight loss to mental health, we provide the personalized medications your unique journey requires.

We’re striving for the personal side of healthcare. Join us in Defying the Odds.

Spring Creek Pharmacy

Booth #535

3737 Mapleshade Ln Plano, Texas, 75075

United States

Ph: (972) 517-7900

Email: info@springcreekpharmacy.com

www .springcreekpharmacy .com

Spring Creek Pharmacy is a full-service compounding pharmacy based in Plano, Texas. We hold non-resident pharmacy licenses in 45 states, allowing us to dispense and deliver compounded IV wellness therapies nationwide. We routinely fill prescriptions ranging from everyday maintenance medications to complex compounded formulations, with same-day or next-day shipping. Our highly trained staff is committed to setting the standard for patient care and takes pride in offering transparent, competitive pricing for self-pay patients.

Sweetgrass Pharmacy Carolina Park

Booth #1108

3485 Pharmacy Carolina Park

Mount Pleasant, South Carolina, 29466

United States

Ph: (843) 696-9103

Email: Team@sweetgrasspharmacy.com

www .sweetgrasspharmacy .com

Sweetgrass is a double nationally accredited 503A compounding pharmacy licensed in 34 states and Puerto Rico. We partner with thousands of providers and patients to deliver high quality, life-enhancing formulas, including:

• GLP-1s

• Bioidentical hormones

• Wellness injectables (FDA approved peptides, vitamins, sexual health, more)

• Dermatology topicals for medical and cosmetic conditions

Prescribing is easy:

• Submit patient-pay prescriptions through any EMR

• Create a dedicated account for office-pay orders and preferred pricing

T.A. Sciences

Booth #113

7975 N Hayden Rd,. Ste C-101

Scottsdale, Arizona, 85258

United States

Ph: (212) 588-8805

Email: info@tasciences.com

www .tasciences .com

T.A. Sciences®, founded in 2002, is dedicated exclusively to creating research-based, clinically tested wellness products that help address telomere shortening through the science of Telomerase Activation.

Built upon a foundation grounded in scientific evidence, T.A. Sciences® is recognized as the leader in the field of Telomere Biology. T.A. Sciences® spends over $1 million each year on leading edge scientific research, including double-blind, randomized placebo-controlled studies proving the safety and effectiveness of its premiere product TA-65®

Tailor Made Compounding

Booth #441

200 Moore Drive

Nicholasville, Kentucky, 40356

United States

Ph: (859) 887-0013

Email: cs@tmcrx.com

www .tailormadecompounding .com

The Tailor Made Difference

A Higher Standard of Care

As experts in compounded medications, we provide custom wellness solutions to satisfy the unique needs of all types of patients. Our individualized treatments not only yield better health results - but maintain them for years to come.

Visit us at www.tailormadecompounding.com to learn more about our integrative care treatments!

Terra Biological LLC

Booth #643

3830 Valley Centre Drive., Ste 705, PMB 561

San Diego, California, 92130

United States

Ph: (858) 947-5722

Email: acash@TerraBiological.com

www .oxaloacetateCFS .com

Terra Biological develops therapeutic compounds that target the metabolic environment for support of anti-aging, improved energy and better cellular functioning. Its flagship product, “benaGene” (Oxaloacetate) delivers many benefits:

• Anti-Aging. A potent calorie restriction mimetic

• Glucose System Support. AMPK activation for stable glucose support

• Fights Fatigue/Increases Endurance. Used by Olympic and National Athletes

• Supports Mitochondria. Stimulates mitochondrial biogenesis

• Reduces Inflammation Pathways. Reduction in the mTOR and NF-kB inflammation pathways www.benaGene.com

The Akkermansia Company

Booth #841

1000 N. West Street., Ste 1200

Wilmington, Delaware, 19801

United States

Ph: (833) 962-6382

Email: info@theakkermansiacompany.com www .theakkermansiacompany .com

The Akkermansia Company discovered and decoded Akkermansia muciniphila, then developed its most effective form—pasteurized Akkermansia MucT®— the most studied and well-understood form of this bacterium clinically shown to support gut and metabolic health and longevity.

The Akkermansia Company offers supplements formulated to deliver clinically proven doses of Akkermansia MucT® to address core aspects of metabolic health, support gut lining integrity, and promote overall wellness.

The Guest House Ocala

Booth

#1140

3230 Northeast 55th Avenue

Silver Springs, Florida, 34488

United States

Ph: (855) 483-7800

Email: info@theguesthouseocala.com www .theguesthouseocala .com

The Guest House Ocala provides premierquality treatment to those who suffer from self-defeating behaviors related to trauma. Our safe and confidential environment supports healing from trauma-induced substance abuse, process addiction, anxiety, and depression. Our dedicated approach includes Dr Yousef Elyman, our Functional Medicine Director, who focuses on the medical aspects of care. We are committed to helping our guests achieve lasting recovery and enhanced well-being through a holistic approach that addresses both physical and emotional needs.

The Light System

Booth #743

30 N. Gould Street, Ste N Sheridan, Wyoming, 82801

United States

Ph: (954) 738-4704

Email: contact@thelightsystems.com www .thelightsystems .com/

The Light System™ is a proprietary, non-invasive wellness technology that integrates light, color, frequency, sacred geometry, and intention to support whole-being balance. Designed to activate the body’s innate intelligence and restore harmony across the physical, emotional, mental, and energetic systems. It generates coherent biophotonic fields that supports nervous system regulation, emotional release, and vitality. With 16 unique programs, these systems are used in homes, retreats, and holistic centers worldwide to deliver deeply restorative experiences—all while simply sitting within the field.

Next-Generation Biologics.

ZEO ScientifiX™ develops and manufactures biologic products designed for investigational and regulated clinical environments. Our products are produced in an FDA-registered, cGMP-compliant facility using controlled manufacturing processes and rigorous documented quality systems.

Patient Pure X® (PPX®)

Autologous extracellular vesicle concentrate

Derived from a patient’s own peripheral blood

• Standardized EV concentrate

DayZero™ Exosomes

Perinatal tissue–derived extracellular vesicles

High-purity vesicle preparations

Available in aesthetic and therapeutic formats

Umbilical Cord Stem Cells

• Umbilical cord–derived mesenchymal stem cells

• Manufactured under controlled laboratory conditions

• Available in vials and ready-to-use IV bags in multiple concentrations

Wharton’s Jelly Matrix

Extracellular matrix derived from umbilical cord tissue

Naturally occurring growth factors and signaling molecules

• Prepared using controlled tissue processing protocols

The Liver Clinic

Booth #734

2030 Main St., Ste 1300

Irvine, California, 92614

United States

Ph: (310) 775-3655

Email: antonia@loveyourliver.com

www .loveyourcliver .com

The Liver Clinic is a physician-partnered division of Equilibrium Labs focused on liver disease prevention, metabolic health optimization, and the identification and management of direct liver-related conditions. Using liver health as a foundational driver of whole-body metabolism, the Clinic emphasizes early risk detection and effective intervention, with the primary use of its novel proprietary formula, de-liver-ance®, to support clinically grounded, scalable programs that improve long-term metabolic and liver health outcomes for patients.

The Pharmacy Hub

Booth #1041

15600 NW 15th Ave., Ste C

Miami, Florida, 33169

United States

Ph: (888) 958-1382

Email: partnerships@thepharmacyhub.com

www .Thepharmacyhub .com

The Pharmacy Hub is a National B2B fulfilment pharmacy for commercial and compounded prescription medications. We provide compliant, scalable while labeled pharmacy fulfilment across all 50 states, supporting innovative healthcare partners with accurate, timely, and high-volume dispensing of both compounded and traditional medications shipped directly to patients.

Thinnr

Booth

#141

3225 S. Macdill Ave., Ste 129-151 Tampa, Florida, 33629

United States

Ph: (908) 720-6069

Email: matthew@thinnrweightloss.com getthinnr .com

Thinnr is the first provider-guided, all-natural, FDA-registered medical weight loss solution designed to help patients achieve sustainable, science-backed results. We empower medical spas, aesthetic practices, and healthcare providers with an innovative, easy-to-implement program that enhances their patient offerings and boosts revenue.

Tiny Health

Booth #1028

6104 Old Fredericksburg Rd., Ste 91622 Austin, Texas, 78749

United States

Ph: (512) 549-6369

Email: practitioners@tinyhealth.com poweredbytiny .com

The first and only precision microbiome wellness platform designed for lifelong health, from the first 1,000 days to the last. Founded in 2020 and built by microbiome scientists and physicians, Tiny Health uses shotgun metagenomics to deliver strain-level and functional microbiome insights. Its research-backed gut and vaginal tests help families and practitioners address the root causes of many chronic conditions with evidence-based interventions. Trusted by over 100,000 people, Tiny Health is redefining the microbiome as a cornerstone of personalized wellness.

Topi Click

Booth #1106

300 Parkebrook Place., Ste 210 Woodstock, Georgia, 30189

United States

Ph: (877) 870-8448

Email: info.TopiClICK@cordicamedical.com topi-click .com/

Topi-CLICK®, the industry leader in metered dosing applicators, offers a wide range of dosing methods to support its flagship brand, Topi-CLICK® 35. Unrelenting in pursuing new technologies and innovation, Topi-CLICK® has created leading-edge advancements in dosing applicators. Request FREE copies of the Analytical Research Laboratories’ accuracy studies and FREE product samples at https://topi-click.com/.

TruDiagnostic

Booth #1100

881 Corporate Drive Lexington, Kentucky, 40503

United States

Ph: (502) 648-3789

Email: support@trudiagnostic.com www .TruDiagnostic .com

TruDiagnostic is transforming personalized health through advanced epigenetic testing. Working with world-leading institutions, we empower healthcare providers, individuals, and researchers with insights to take proactive steps toward better health and breakthrough discoveries. Driven by a passion to understand aging and optimize health, we’re building a future where lives are longer, healthier, and more vibrant. Join us to make a meaningful impact and be part of something truly extraordinary.

The Biologics Standard.

Advancing biologics through controlled manufacturing, ethical sourcing, and scientific collaboration.

ZEO ScientifiX™ is a research and manufacturing company specializing in biologic materials for investigational, regulated clinical environments, and for commercial distribution to licensed providers and institutions.

Operating in partnership with Nova Southeastern University, Florida’s largest private research university, ZEO ScientifiX is headquartered within NSU’s Collaborative Center for Research. Our products are developed through controlled quality systems and rigorous release standards while supporting ongoing clinical research initiatives.

Biologic Portfolio

• Umbilical Cord Stem Cells

• Patient Pure X® (PPX®)

• DayZero™ Exosomes

• Wharton’s Jelly matrix

• Wound Care Biologics

(In partnership with Cytora and Made Scientific)

Ethical Sourcing

• 100% non-fetal, non-embryonic materials

• AABB-Accredited Tissue Banks

• Traceable sourcing chain

Manufacturing Dicipline

• FDA-registered HCT/P manufacturer (21CFR Part 1271)

• cGMP-compliant facility

• Independent 3rd-party testing

Vale Medical

Booth #1000

7231 S. 900 East., Ste 200 Midvale, Utah, 84047

United States

Ph: (561) 379-6230

Email: carmine@valemedical.com

valemedical .com/

At Vale Medical, our commitment to excellence is at the heart of every customer relationship. We go beyond delivering devices by fostering long-term partnerships built on trust and support. From advanced shockwave therapy solutions to comprehensive rehabilitation technologies, we are dedicated to supporting clinical success through ongoing education and collaboration. By prioritizing continuous growth and shared outcomes, we ensure our customers feel confident and supported at every stage of patient care.

Vertisis Custom Pharmacy

Booth #5

9343 E. Bahia Drive., Ste 200 Scottsdale, Arizona, 85260

United States

Ph: (303) 476-3447

Email: matthewb@vertisis.com

www .vertisis .com

Vertisis is one of the most unique sterileinjectable compounding pharmacies in the United States. Our focus is on going “above and beyond” traditional compounding pharmacies by raising the standards of 503A compounding pharmacies to include exceptional products, unique delivery, advanced education, and an amazing relationship with health care providers with a seamless delivery of care. We are Vertisis Custom Pharmacy, your custom compounding pharmacy for integrative and naturopathic IV therapies and compounds.

Vitalgenics Stem Cells & Biologics

Booth #906

1203 NE 23rd St.

Mineral Wells, Texas, 76067

United States

Ph: (303) 886-1898

Email: joey.edge@Vitalgenics.net

Vitalgenics .net

Vitalgenics supplies the vanguard of umbilical cord blood–derived stem cells and exosomes, delivering rigorously sourced, science-driven biologics to forward-thinking physicians and clinics nationwide. Beyond biologics, the Vitalgenics platform supports healthcare professionals through clinical education, treatment protocols, and compliance guidance— empowering providers to safely integrate cutting-edge regenerative solutions that promote healing, longevity, and optimized outcomes at the cellular level, supported by transparent quality standards, advanced processing, and ethical sourcing.

VitaminLab

2-2110 Store

Victoria, British Columbia, VAT4R4

Canada

Ph: (778) 288-5509

Email: info@getvitaminlab.com

getvitaminlab .com

VitaminLab works with practitioners and testing companies (blood, DNA, microbiome) to create truly custom supplement formulas that are effective and accurate.Founded on the basis of biochemical individuality, VitaminLab is committed to providing one of a kind personalized and custom vitamin health solutions to as many individuals as possible. We produce all our vitamins in our cGMP facility in Canada.

Vibrant Wellness

Booth #813

3521 Leonard Ct

Santa Clara, California, 95054

United States

Ph: (816) 868-5964

Email: support@vibrant-america.com

www .vibrant-wellness .com

Vibrant Wellness is a leading science and technology company delivering life-transforming laboratory services using an integrated microarray platform that enables multiplex testing at an affordable cost.

VITL

Booth #546

222 2nd Ave S

Nashville, Tennessee, 37201

United States

Ph: (952) 500-2156

Email: justyn@vitlrx.com www .vitlrx .com

VITL is the modern medication operating system for cash-pay clinics - prioritizing speed, transparency and simplicity. We let providers e-prescribe compounded medications across a network of pharmacies, all from a single, intuitive platform - sending prescriptions in seconds, not minutes. Staff save hours each week through centralized ordering, tracking and customer support. The result is lower operational friction, lower medication costs, and a better experience for patients. No cost, no contracts. Just a better way to e-prescribe.

Booth #833

Viviscal PRO

Booth #1015

500 Charles Ewing Blvd

Ewing, New Jersey, 8628

United States

Ph: (800) 277-3316

Email: support@vxprohair.com

www .vxprohair .com

Rethink thinning hair with clinically studied Viviscal PRO. The drug free blend of vital nutrients, including our exclusive AminoMar™ marine complex, promotes healthy hair growth from within.

• Made with AminoMar™ which has been studied in 10 clinical trials

• Clinically shown to nourish thinning hair, improve scalp coverage and support growth*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

VO2 Master Health Sensors Inc.

Booth #840

2906 33rd Street

Vernon, British Columbia, V1T 5S7

Canada

Ph: (778) 475-5755

Email: info@vo2master.com

vo2master .com

VO2 Master enables longevity professionals to move beyond estimates and confidently assess metabolic health with precision. By directly measuring oxygen consumption during active and resting tests, practitioners gain objective insight to personalize exercise prescriptions, guide long-term vitality strategies, and support proactive healthspan optimization. Quantifying aerobic fitness—one of the strongest predictors of longevity—allows professionals to track physiological aging over time, validate intervention effectiveness, and clearly demonstrate measurable improvements in metabolic health using specific, actionable data clients can understand and trust.

VSL#3 - Actial Nutrition

Booth #1113

808 S. Public Rd., Ste 202

Lafayette, Colorado, 80026

United States

Ph: (866) 438-8753

Email: support@vsl3usa.com

www .vsl3 .com

VSL#3 is a medical food probiotic for the dietary management of IBS, UC and pouchitis. Countless patients have relied on VSL#3 to manage their gut issues for over a decade in the US.

VSL#3 is currently the #1 gastroenterologistrecommended multi-strain probiotics brand in the US.

We Care Pharmacy

516 Fletcher Dr. Warrenton, Virginia, 20186

United States

Ph: (540) 428-7002

Email: Paula@wecarepharm.com

wecarepharm .com

WeCare Pharmacy is a full-service compounding pharmacy specializing in IV therapy, BHRT, weight-loss, mean’s and Woman’s health, other integrative and anti-aging therapies. Our goal is to come alongside your practice and provide you with creative products that help make you effective clinicians, innovative business owners and valued clinicians to your patients.

Weave

Booth #236

1331 W Powell Way

Lehi, Utah, 84043

United States

Ph: (435) 503-5337

Email: becky.petersen@getweave.com

www .getweave .com

Weave is the all-in-one experience platform for small- and medium-sized healthcare businesses. From the first phone call to the final invoice and every touchpoint in between, Weave connects the entire customer journey. Weave’s software solutions transform how healthcare businesses attract, communicate with, and engage patients to grow their business.

Wellness Pharmacy

Booth #106

3401 Independence Dr., Birmingham, Alabama, 35209

United States

Ph: (800) 227-2627

Email: info@wellnesspharmacy.com

www .wellnesspharmacy .com

With over 60 years of compounding experience, Wellness Pharmacy is considered the industry leader in quality and customer service. Our specialties include chelation, bioidentical hormones, autism support, and preservativefree injectables. Wellness Pharmacy is also the only pharmacy to successfully patent the preparation of injectable glutathione. PCABaccredited.

Booth #432

Wells Pharmacy Network

Booth #933

3420 Fairlane Farms Rd., Ste 300 Wellington, Florida, 33414

United States

Ph: (561) 793-1568 x2631

Email: info@wellsrx.com

www .wellsrx .com

Wells Pharmacy Network is a privately held, nationwide, compounding pharmacy specializing in solutions for wellness and anti-aging medicine including: Bio-Identical Hormone Replacement Therapy, Peptide & Regenerative Therapies, Weight Management, Sexual Wellness, Aesthetic Dermatology and Thyroid & Adrenal Health. This includes operating a 20,000SF 503A pharmacy and a 21,000SF FDA Registered 503B Outsourcing Facility that produces bulk medication. Our mission is to elevate compounding industry standards through a unique combination of superior science and service.

WorldHealth.net

Booth #154

1510 West Montana Street

Chicago, Illinois, 60614

United States

Ph: (773) 528-6100

Email: worldhealthnet@gmail.com

www .worldhealth .net

Unlock the secrets to a longer, healthier life with our free, science-backed resource dedicated to extending your healthspan. We provide actionable, expert-reviewed information on nutrition, exercise, sleep optimization, and lifestyle strategies designed to combat aging, reduce chronic disease risk, and improve vitality at any age. Discover evidence-based hacks, from boosting cellular health to managing stress, enabling you to live not just longer, but better. Explore our curated insights and start enhancing your longevity journey today.

Xhalo360

Booth #645

11501 Dublin Blvd., Ste 200 Dublin, California, 94568

United States

Ph: (925) 989-8818

Email: zarina.bafaiz@xhalo360.com

www .xhalo360 .com

XHalo360 is an AI-powered wellness and longevity platform designed for concierge and specialty practices. It unifies treatment plan management, membership automation, medication and lab integrations, billing workflows, and patient engagement into one intelligent system. Providers can build outcome-driven programs such as GLP-1 weight loss, hormone optimization, and preventive care with structured tracking and renewal automation. Patients use a connected app for check-ins, tasks, and progress monitoring, enabling scalable, data-driven, and highly profitable care delivery.

ZEO ScientifiX

Booth #707

3300 S. University Drive., Ste 246 Fort Lauderdale, Florida, 33328

United States

Ph: (800) 541-6682

Email: info@zeoscientifix.com

zeoscientifix .com

ZEO ScientifiX (OTCQB: ZEOX) is a research and manufacturing company focused on the controlled production of biologic materials for investigational, research, and regulated clinical applications. Based at Nova Southeastern University’s Collaborative Center for Research, we support providers and institutions with documented quality systems and release standards while advancing a clinical research pipeline. Our portfolio includes ethically sourced birth-tissue-derived products, including mesenchymal stem cells, stem cell-derived exosomes, Wharton’s Jelly matrix, placental membrane tissues, and amniotic fluid, manufactured in FDA-registered, cGMP-compliant facilities.

Zizion® Group Inc.

Booth #907

141 NW 20th Street., Ste G1

Boca Raton, Florida, 33431

United States

Ph: (561) 221-1000

Email: bruce@zizion.com

www .zizion .com

Zizion® Group, an FDA-registered medical distributor, through its division RegenOMedix™, specializes in integrative therapies for hair regeneration, aesthetics, orthopedics, sexual wellness and wound healing. We empower health professionals with advance products, such as Peptides, stem cells, exosomes, PRP, Nanopen®, targeted training, and innovative marketing that enhance patient outcomes and expand practices. Through a collaborative partnership model, we provide tailored solutions, expert guidance, and ongoing support, ensuring, longterm success and growth.

ZRT Laboratory

Booth

#607

8605 SW Creekside Pl Beaverton, Oregon, 97008

United States

Ph: (503) 466-2445

Email: info@zrtlab.com

www .zrtlab .com

ZRT Laboratory, a CLIA-certified commercial and research laboratory, is the recognized leader in innovative and meaningful hormone and wellness testing. ZRT has pioneered testing methods for hormones, neurotransmitters, heavy metals and more, offering health care professionals convenient testing options in different body fluids including saliva, dried blood spot and dried urine. ZRT provides comprehensive test results that allow providers to create personalized treatments for optimal outcomes.

FEATURED SPEAKERS 34 TH ANNUAL WORLD CONGRESS

Join us for 4 days with 200+ sessions, 9,000+ attendees, and unmatched networking. From metabolic science to regenerative medicine, experience the longevity innovations shaping the future of healthspan.

Robin Berzin, MD

Jeﬀ Bland, PhD

Brian Kennedy, PhD

Robert Love, PhD

Vincent Pedre, MD

A4M | Anti-Aging Medical News - Spring 2026

Dear Longevity Leaders,

Show Regulations

MEET THE PLANNING COMMITTEE MEMBERS

Sponsors

PLATINUM

Thank you! Partners

WORKSHOPS (NON-CME)

Brain Energy, Aging & Injury

Targeting Metabolic Constraints in Older Adults

The Only Lab That Pairs Functional Biomarkers with Whole-Genome Intelligence

Transforming Gut Health with GI Effects®

METABOLIC DYSFUNCTIONASSOCIATED FATTY

LIVER DISEASE: Epidemiology, Pathogenesis, Disease Progression, and Unmet Needs

Abstract

Introduction and Evolution of Nomenclature

Global Incidence and Prevalence

Worldwide Burden

Incidence, Age, and Sex Eﬀects

Ethnicity and Socioeconomic Determinants

Etiology and Risk Factors

Obesity and Adipose Tissue Dysfunction

Dietary Drivers: Sugars, Ultra-Processed Foods, and Sweeteners

Genetic Susceptibility and Epigenetic Regulation

The Gut-Liver Axis

Pathogenesis of Hepatic Injury

Organelle Stress

Inﬂammation and Immune Activation

Fibrogenesis and Matrix Remodeling

Progression to MASH, Cirrhosis, and Hepatocellular Carcinoma

Metabolic Dysfunction-Associated Steatohepatitis

Cirrhosis and Decompensation

Hepatocellular Carcinoma

MAFLD as a Multisystem Disease: Extrahepatic Manifestations and Systemic Consequences

Cardiovascular Disease

Brain Function and Neurocognitive Health

Skeletal Muscle and Sarcopenia

Bone Metabolism and Osteoporosis

Chronic Kidney Disease

Intestinal Function and the Gut Barrier

Adipose Tissue as an Endocrine Organ

Knowledge Gaps and Unmet Needs

Future Directions

Essential References for Further Reading

Become a Registered DUTCH Provider

OPTIMIZING ESTROGEN THERAPY IN

MENOPAUSE:

Why Hormone Testing Matters for Osteoporosis Prevention

Estrogen’s role in women’s bone health

How much estrogen is needed for bone protection?

Hormone testing allows optimization of estrogen therapy for bone protection

References:

Mitochondrial Function

Detoxification Capacity

Nutrient Metabolism

Neurotransmitter Support

METABOLIC ASSESSMENT AS A CORNERSTONE OF ANTI-AGING MEDICINE:

Clinical Insights from Comprehensive Urinary Biomarker Analysis

Introduction

Mitochondrial Function, Energy Production, and Aging

Detoxiﬁcation Pathways, Oxidative Stress, and Longevity

The Gut is important for Metabolism and Mental Health

Neurotransmitter Metabolism and Cognitive Aging

Measuring Nutrients in the Body can assist Anti-Aging

Clinical Integration in Anti-Aging Practice

References:

Advanced Hormone Testing Led by Science & Innovation

Peptide Science Meets Postbiotic Power with NeuroCalm

Supporting Healthy Aging Through Gut–Brain and GABA Pathway Modulation

Designs for Health

Lactobacillus gasseri CP2305: A HeatTreated Para-Psychobiotic

Stress Resilience in Clinical Trials with L. gasseri CP2305

Lactium® (α-Casozepine): Central GABAA Receptor Support

Clinical Stress and Sleep Outcomes with Lactium® (α-Casozepine)

Summary: Integrating Gut-Brain and GABA Pathways in Healthy Aging Care

Author Biography

References:

Bioactive Peptides for Restorative Sleep Powered By SleepTides™

MODULATING THE OREXIN PATHWAY: A Melatonin-Free, Peptide-Based Strategy for Restorative Sleep

Biotics Research Team