New Discoveries Of Metformin

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New Discoveries Of Metformin Metformin, as a global core drug for type 2 diabetes, has a market size of more than 6 billion yuan in total in sales terminals such as public medical institutions and physical pharmacies in China in 2018. With the deep research, the therapeutic potential of the magic drug metformin has been continuously expanded. Let's take a look at the new discoveries of metformin.

1. Metformin can repair brain damage In Nature Medicine journal, researchers from the Institute of Medical Sciences of the University of Toronto in Canada and the Toronto Children's Hospital published a clinical trial. For children with brain tumors who have been treated with craniocerebral radiotherapy, metformin significantly improved their working and declarative memory functions and repaired damage to white matter compared with placebo.

The researchers concluded that the effects of metformin on cognition and brain structure is feasible in long-term survivors of pediatric brain tumors and metformin is safe and tolerable in this population. This pilot trial was not intended to test the efficacy of metformin for cognitive recovery and brain growth, but the preliminary results are encouraging and warrant further investigation in a large multicenter phase 3 trial.

2. Metformin can help you lose weight Metformin is a kind of hypoglycemic drug that can lose weight. It can increase insulin sensitivity and reduce fat synthesis. For many type 2 diabetes patients, weight loss is helpful for stabilizing blood sugar. A study by the United States Diabetes Prevention Program (DPP) research team showed that patients receiving metformin treatment lost an average of 3.1 kg in weight in 7-8 years.

Metformin is a kind of diabetes can reduce weight.It can increase insulin sensitivity, reduce adipose synthesis.And for a lot of sugar type 2 friends, weight reduction is in itself a something for the stable blood sugar control.A study by the American Diabetes Prevention Program (DPP) research team showed that patients treated with metformin lost an average of 3.1 kilograms of weight over a seven-year to eight-year period in an open-access study.

3. Metformin can delay aging A few days ago, the FDA approved a clinical trial of “metformin against aging�. Foreign scientists use metformin as an anti-aging drug candidate probably because metformin can increase the number of oxygen molecules released into cells. In theory, it seems to increase the body's fitness and extend life.

4. Metformin can reverse biological age

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The international scientific journal Nature published a blockbuster news. Reports show that a small clinical study in California showed for the first time that it is possible to reverse the human epigenetic clock. In the past year, nine healthy volunteers took a mixture of growth hormone and two diabetes drugs, including metformin. By analyzing markers in a person's genome, their biological age dropped by an average of 2.5 years.

5. Metformin can help you quit smoking Researchers from the University of Pennsylvania have found that long-term nicotine use can lead to the activation of the AMPK signaling pathway, and the AMPK signaling pathway is inhibited when nicotine withdrawal. Therefore, they inferred that if drugs are used to activate the AMPK signaling pathway, they may alleviate the withdrawal response.

Metformin is an AMPK agonist. When the researchers gave metformin to mice that had nicotine withdrawal, they found that it relieved the withdrawal response in the mice. Their study shows that metformin can be used to help quit smoking.

6. Metformin can inhibit inflammation Preclinical studies and clinical studies have shown that metformin not only improve chronic inflammation by improving metabolic parameters such as hyperglycemia, insulin resistance and atherosclerotic dyslipidemia, but also has a direct anti-inflammatory effect.

Studies have pointed out that metformin can inhibit inflammation, primarily through AMP-activated protein kinase (AMPK)-dependent or independent inhibition of nuclear transcription factor B (NFB).

7. Metformin can promote hair growth and treat hair loss

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The team of Huang Jing, a Chinese scientist from the University of California, Los Angeles, discovered that drugs such as metformin and rapamycin can stimulate the hair follicles in the resting phase of mice to enter the growth phase and promote hair growth. Related research has been published in the famous academic journal Cell Reports. Moreover, when using metformin to treat patients with polycystic ovary syndrome in China and India, scientists have also observed that metformin is associated with hair loss.

8. Metformin can reduce the risk of miscarriage and preterm birth in certain pregnant women Metformin may reduce the risk of miscarriage and preterm birth in certain pregnant women. According to reports, scientists from Norwegian University of Science and Technology the Norwegian University of Science and Technology (NTNU) and St. Olavs Hospital conducted a nearly 20-year study and found that patients with polycystic ovary syndrome taking metformin at the end of 3 months of pregnancy may reduce post-term miscarriage and miscarriage. Risk of premature birth.

9. Metformin can inhibit tumor growth Researchers at the European Institute of Cancer Research have found that metformin and fasting can work synergistically to inhibit tumor growth in mice.Further studies have shown that metformin and fasting inhibit tumor growth through the PP2A-GSK3 -MCL-1 pathway. This research was published on Cancer Cell.

10. Metformin can treat three-negative breast cancer A team led by Dr. Marsha Rich Rosner of the University of Chicago, found that metformin, in combination with another older drug, Panhematin, could target triple-negative breast cancer, which is a serious threat to women's health. And there is evidence that the treatment strategy may be effective against a wide range of cancers, including lung cancer, kidney cancer, uterine cancer, prostate cancer and acute myeloid leukemia, according to the study published in journal Nature.

Metformin is the first-line drug for the treatment of type 2 diabetes (T2DM) and it has been widely used in clinical practice. Huateng Pharma, a leading pharmaceutical company focusing on R&D of pharmaceutical intermediates, we provide Anti-Diabetic intermediates such as semaglutide intermediates and liraglutide intermediates with high purity.

Reference: Assessment Of Cognitive And Neural Recovery In Survivors Of Pediatric Brain Tumors In A Pilot Clinical

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[5] Does Metformin Benefit The Risk And Survival Of Lung Cancer In T2DM Patients?