Bula Expec

123145 789

! " # $ 8% 8 & '

()* + ,( + * + - +

012034 6789 9 8 8 8

8 8 8 8 8 8 8

0 ,! 3"#$% % &0 3"&0 %' ()*(+ -./012034/ 25 /6/75738193 : 1/254/ 25 ;/4<==1/ : >598/34/ 25 =?21/

"2@0A0 "#B0A )30/;5C D03=-/ -/7 EFG7HC

IA% %@"J IA% " IJ % 0 20 K @ 3% "3 &" 0 L " %A 0 " 0

3%&2%A #$% +323 M 7H 2/ 630/;5 -/94N7O -./012034/ 25 /6/75738193CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCF7P 1/254/ 25 ;/4<==1/CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEGG7P >598/34/ 25 =?21/CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCFG7P PQ31R595=193CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSG7P T5U-Q./V WC=C;CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCM7H V X1545./=5Y =3-30193 =?21-3Y X120?612/ 25 =?21/Y 5==Z9-13 25 R037>/5=3Y 5==Z9-13 25 -30375./Y -/03945 T5075.X/ >/0253Q6Y -1-.3734/ 25 =?21/Y <.-//. 54U.1-/Y <-12/ -U401-/Y <PQ3 ;Q01R1-323C

!%@&"#B0A "% 2"3 0 0

[\ 2"@" ]I0 0A 0 &0 3"&0 % ^ 3" %_ ()*(+, 5=4< 1921-32/ 9/ 403437594/ =194/7<41-/ 23 4/==5 `10014341T3Y 9a/ ;0/2Q41T3Y 5=;3=7?21-3Y =5-3b 3==/-1323 3 T<013= -/921cd5= 05=;1034?013=C

L\ 3%&% 0A 0 &0 3"&0 % !I 3 % "_ ()*(+, N Q7 7521-37594/ 39414Q==UP59/ 5 56;5-4/03945Y 05=Q.43945 23 3==/-13ca/ 23 /6/75738193Y 3941eX1=437U91-/ 25 =U945=5Y 2/432/ 25 ;0/;0152325= 39414Q==UP593= 5 =52341T3=f PQ31R595=193Y 3941==N;41-/ 23= T13= 05=;1034?013= 5 56;5-4/03945f >598/34/ 25 =?21/Y R.Q121R1-3945 23= =5-05cd5= >0g9WQ1-3= 5 56;5-4/03945C

h\ ]I" % $% 0i% IA"@ 0A 0 &0 3"&0 %_ ()*(+, N -/94031921-32/ j= ;5==/3= =59=UT51= 3/= -/7;/95945= 23 R?07Q.3Y 3 ;3-15945= =59=UT51= 3/ 1/2/ /Q WQ5 3;05=59437 19=QR1-1Z9-13 05=;1034?013Y WQ3.WQ50 WQ5 =5k3 / P03QY 3R5-cd5= X5;<41-3= 5 05931= P03T5=C

0 6 8 l 68 9

6 8 9 89 L 8 \

m\ % ]I0 0i% A"n0@ " 0A 0 IA"@ 0A 0 &0 3"&0 %_ (=45 ;0/2Q4/ 25T5 =50 327191=4032/ -/7 7Q14/ -Q1232/ 57 ;3-15945= WQ5 3;05=59437 43WQ1-30213Y 19=QR1-1Z9-13 -302U3-3 /Q R3.Z9-13 -/0/9301393C o945= 2/ 19U-1/ 2/ 403437594/ 39414Q==UP59/Y N -/9T5915945 WQ5 =5 19T5=41PQ57 3= -3Q=3= 23 4/==5Y ;303 125941R1-30 3WQ5.3= WQ5 05WQ5057 403437594/ 541/.?P1-/ ;0?;01/Y ;019-1;3.75945 3=73Y -p9-50Y 3R5-cd5= 592/>0g9WQ1-3=Y 59405 /Q403=C +3=/ 3 4/==5 ;50=1=43 3;?= 3 327191=403ca/ 25 39414Q==UP59/ 57 2/=5= Q=Q31=Y 9a/ N -/9T5915945 WQ5 =5 3Q75945 3 ;/=/./P13Y 73= WQ5 =5 R3c3 Q73 05T1=a/ 23 =14Q3ca/ -.U91-3C q 25=3-/9=5.X32/ / -/9=Q7/ 25 >5>123= 3.-?/.1-3= 2Q03945 / 403437594/ -/7 ()*(+, 25T12/ j ;05=59c3 25 /6/75738193C r5T5e=5 450 -3Q45.3 3/ 327191=4030 3 1921TU2Q/= -/92Q4/05= 25 T5U-Q./= /Q 7<WQ193= ;/459-13.75945 ;501P/=3=Y 25T12/ 3/ 01=-/ 25 =/9/.Z9-13C

s9 t O 3 19/-Q12325 25 ()*(+, 2Q03945 3 P03T1258 31923 9a/ R/1 5=43>5.5-123C */04394/Y 05-/75923e=5 WQ5 3 =Q3 Q41.183ca/ =/75945 =5k3 R5143 3;?= 3T3.13ca/ 23 05.3ca/ 01=-/e>595RU-1/C

89 8 l 68 86899u 6

9 t

t u 6

8 9

8 8 8 l9 8\ 89 8 l 68

8\

9 vw, 6 8

()*(+ ;/25 ;/459-13.1830 /= 25;05==/05= 2/ xy+Y >57 -/7/ /= 340/;U91-/= -594031=Y WQ392/ 57 3==/-13ca/ -/7 /Q403= =Q>=4p9-13= 3941-/.19N0P1-3= `/Q40/= 3941eX1=437U91-/=Y 25;05==/05= 171;037U91-/=Y 95Q0/.N;41-/= R59/4138U91-/=Y 3941;30z1=/9139/= 3941-/.19N0P1-/=Y 39415=;3=7?21-/= 340/;U91-/= 5 21=/;1037123bC

0 234 54654789 69 547 82 98543 42

4 3 49 3384 4 7 8 49 33 78 8 5 78

8978 3 5

5 3

! "# $%&' # '& # (&) *% +&"+! " , '- "+. !/ % #" % !0(# #+ %&'! + 1 2) #" %&'! + " ' 3'& + % "# $%&' 1 4 % " 5 &( " 5! ! "#! "!6%1

71 829:; <8=8 : 48> ?@A2B8 B:=48 48CC8 D@A>9A> :CB: =:9 <A=:2B8E F 69 9 7 92

7G8 69 69 HIJK LMJK N 49 O

2P 7 69 7 2O 3 54

26 % 0 + %!+!" % !Q &'!R) ,!0&%!%S ,&% Q!0!( 1

2) #" %&'! + ' 5 !/ % ,!0&%!% , '&% 1 D#! %* "#! Q!0!( &(& !01 V TUNTK 3 69 W3 5474 X 4 7 8 4Y 6 54 43

7

4Y 547 3 G4 4 4 Z 7G4 3

A +" % #"! ; Q" , !"5'+ % %&'! + 1 <!" 0 "+[! 5 !/ % ,!0&%!% , '- Q" , !0(# ! #%! R! !"5'+ ; ' "#0+ ! !'-#+&' 5! ! "!Q " 5 % . #+&0&/.*0 1

B898 =:9 <A=:2B8 9:\: C:> =A2B 98 ]8>A 98 A^<A2<: 9AC <> A2_AC1

`1 <8=8 9:\8 @CA> :CB: =:9 <A=:2B8E A%#0+ a 947 I7b c P 3 4 8

< &! R!" % d ! ` ! "S 947 I7b L e P 3 4 8

< &! R!" % ` ! fd ! "a 947 I7b e c P 3 4 8

C&(! ' +! + % % #"! 1 : '!" % %6,&%!" " Q "+ %&'! + ; 5 '# & +!R) % ! !'-#+&' 1 2) %"!5! ' % " "& + !"; 5 '# & +!R) % "# $%&' # '& # (&) * % +&"+!1

g1 8 ?@: 9:\8 ]Ah:> ?@A298 :@ =: :C?@:<:> 9: @CA> :CB: =:9 <A=:2B8E i47

43 3387 j2 3 7G

T69 9 694Y 3 398 kX874 4 4 84

43 3 O2869 Y 3 9

43 3j2 58

5469862 4 9 9 7 694 546Z4 7 35 894 lm4 298 8P 4 4G 4

43

547 63 27

43 3j2 58

: '!" % %6,&%!"; 5 '# & +!R) % ! !'-#+&' # % "# $%&' ; # '& # (&) *% +&"+!1

n1 ?@A C 8C =A^:C ?@: :CB: =:9 <A=:2B8 489: =: <A@CA>E 0 84 94 49 3384 4 86 2P8 5 343 43 84 8374Y 547 8 3 5 om4

3 O p6 2 3 Xk5 86 3 5474 3 6 3 83Y

5 87 83 9 j2 4G q6j285 3r 5

59 8P W3 4 8 3 3 2 os 3 529p6 3 56 Z4 7 3Y 2 8O8643 3 42 89 7 943 3Y 5 Z 8 3 0 Z 894

34 7 83 54727 69 4G3

4 3464 t658 T69 9 694Y 7 83

7 69 Y 4 W3 4G3 546398 om4 9 6om4 2 86 8 Y 546Z23m4 7 69 Y G45 3 5 Y Z 8943 O 39 869 3986 83 7 9852 8694 p658

8O 398 Y 83586 38 3 9

8 3Y 254 68

O 62 458943

A0+ !Ru" % v! " 0!Q !+ &!&" V N4 5 23

4 84 94 49 3384Y TUNTK 4 869 Z 8 643 X 7 3

9 786 om4

Z26om4

98 48

! "# $%&' ; '& # (&) *% +&"+! # ! !'-#+&' !5! '& + % !Ru" & %"[.,&" 50 #" % %&'! + 1 +! Q$ w 5 "! !+ !,$" % "# " ,&R % !+ %& + 1

x1 8 ?@: ]Ah:> C: A^D@y= @CA> @=A ?@A2B 9A9: =A 8> 98 ?@: A 29 <A9A 9:CB: =:9 <A=:2B8E z 8 4 3 6o

4X47 7 P86 Y 4 j2

4 4 3 5

59 8P

4 4 33m4 547 0 9 9 7 694 386947 9854 Y 692 7 69 Y 4 3 6 5 33 8 3 8 om4 338398

42 98Z858

698546 2 38 69 3

: '!" % #" % ( ! % {#! +&%!% %"+ %&'! + ; 5 '# !5&%! + " ' $%&' 0, !

Q!0!( # Q#0! % %&'! + ; " 5 ""|,01 ^&(# 5! ! }n}} gdd `}}f; " , '- 5 '&"! % !&" & +!Ru"1

9 h:>:C ^:DA C ~ 7 3 a z F 8 9p68 N 8 K ~W N 6J L O F a 6J H c L M H

> (&"+ !% 5 S bT lz lz i ~ F K i K biz 4 4 8 4 6 839 ~ 658354 O28 N 4 6o Y 7 M

012334 6789131 1

43 4 21 6 6 ! "# $$# $ % & '( )*& 0* &+ &*

,-./01-23453/6 7

43 4 21

4 89:4;<;;4=;;>;;4 ???@ABC/-D25E-/F-@13F@./4

4

G

012345167 9

3 5 7 9

972 9 2 122 7

35 16 972 9 31 7 731 16 7

3 5 972 9 2 3 5 2 9

2 3 97 97 3 97 97 22 37 3 9 39

2 52 2 5 2 3 2 2 2

3 7

91 3

91 3

91 3

91 3

57 7 ! " "#$ 5

617 9 2 %(&-.*/* 01234,01+56* * 5?B?=* +676* 8 * 3 9 : ; < = > ? * K L A = : ? *:?M* %&'()')(%&* +',* 39@:@A;*BC*5CDE?* +',* +',* +',* +',* ?=* 7I'7IJ* %)(MN* 3EC9=* BC*F<;A*/*G24* * H('%)* *

**