National and State Syphilis Trends, 2021-2024 In recent years, primary and secondary (P&S) syphilis rates among American Indian and Alaska Native (AI/AN) adults have declined nationwide. However, the rates for P&S and congenital syphilis were highest among AI/AN compared to all other races. In addition, Oklahoma continues to face increasing rates for syphilis and in 2023 ranked among the top 5 states with the highest number of AI/AN syphilis cases. The following report will present recent syphilis trends in the country and among Oklahomans.
28.8
30.7
31.8
2021
2022
27.7 2023
17.3
26.5
15.1
2021
2022
17.0 9.8 2023
2024
Unknown/Late Syphilis Rates 91.5
La
e
14.2
y
4.1
greater for
La
x
greater for
x
tent Sy
p
te nt/ U nk
...compared to their White counterparts (2024).1
108.5
In 2023, Oklahoma was one of the
64.4 39.8
2021
s
16.8
16.1
28.2
S S y p h ili
2.7
rl
P&
greater for
x Ea
Early Latent Syphilis Rates 25.1
2.3
2024
lis
35.2
In Oklahoma, rates among American Indian and Alaska Native adults were....
hi
46.0
wn
53.2
no
Statewide AI/AN
Local Disparities
Lat
Oklahoma Rates (per 100,000 people)
1
P&S Syphilis Rates
37.4
39.6
43.3
2022
2023
2024
TOP 5 STATES
with the greatest number of 2 syphilis cases among AI/AN people.
Congenital Syphilis U.S. Congenital Syphilis Rates by Race 3
National Trends (2023) 680.8 600
In a 10-year period (2014-2023), congenital syphilis rates have increased
5,250%
*per 100,000 live births AI/AN
2
for AI/AN communities across the country.
400
222 200
0
Black/African American
125
Hispanic/Latino
57.3
White
2019
2020
2021
2022
2023
2024 Oklahoma Congenital Syphilis (CS) Rate
118.9
In the U.S., the rate of P&S syphilis among AI/AN women was nearly
10 times higher than White women.2
For free, at-home syphilis and HIV tests
per 100,000 live births 2024 National CS Average Rate: 109.6
Scan the following QR code for more information and resources.
1. Oklahoma State Department of Health. (n.d.). OK2SHARE. Retrieved July 2025 and 2026, from https://ok2share.health.ok.gov 2. Reilley, B., Hoover, A., & Leston, J. (2025). Hidden in Plain Sight: Syphilis Inequities Among American Indian and Alaska Native People, 2022-2023. The American journal of medicine, 138(7), 1106–1109. https://doi.org/10.1016/j.amjmed.2025.02.037 3. Centers for Disease Control and Prevention. (n.d.). STI statistics: Data visualizations. U.S. Department of Health & Human Services. Retrieved July 25, 2025, from https://www.cdc.gov/sti-statistics/data-vis/index.html