Seoul National University College of Medicine Brochure 2018

From the finest Medical University  in Korea  To leading international medical research center

01 S N U C M

G

02

C O N T E N T S •Dean’s Message

04 – 05

•History of Seoul National University College of Medicine

06 – 13

•Part 1. Education and Research

14 – 29

Education

16

Research

24

Campus Life

28

•Part 2. Connection and Expansion

30 – 45

Lee Jong Wook – Seoul Project

32

JW LEE Center for Global Medicine

34

Institute for Health and Unification Studies

36

International Partnerships

40

Alumni

42

Training Hospitals

44

Dean's Message

4

Seoul National University College of Medicine Aiming High for World-class Seoul National University College of Medicine boasts 520 dedicated professors who have an outstanding reputation for excellence in teaching and medical research. With over 2,000 students in undergraduate and graduate programs, we offer the exceptional education and training under the mission of nurturing competent health care providers and scientists. I have the utmost confidence that graduates of our college will play a pivotal role in health care and medical research not just in Korea but also across the world in the future.

After finishing two-year Premedical course, students are provided with in-depth knowledge and scientific understanding of diseases, in addition to vital interpersonal communication skills to engage with patients at the College of Medicine for 4 years.

We also offer a wide range of disciplines of more than 50’s master’s and doctoral programs in biomedical research to help students reach their career goals.

Our faculty is devoted to providing the highest standard of medical treatment and research in all fields of medical science as well as the public contribution to improve global health care and the future of the Korea.

Now we are about to leap towards the world-class institute.

Our goal is to become a leading research-oriented medical college based on fundamental basic science, cutting-edge clinical research, and multidisciplinary biomedical collaboration. We will continue to hone our brilliant academic tradition accumulated by numerous outstanding graduates.

I sincerely hope you to support our journey into a bright future as we continue to aim high for the world-class level. Thank you.

Chan Soo Shin Dean Seoul National University College of Medicine

5

History

1885 Jejungwon

濟衆院

1899 National Medical School

醫學校

Establishment of the first medical school accreditation system in Korea

Establishment of the first modern national hospital in Korea

1946 Seoul National University College of Medicine

Foundation for Korean modern medicine Korea’s history of advancing modern medicine coincides with the history of Seoul National University College of Medicine.

SNUCM was established in 1946, pursuing the philosophy of Ji Seok-yeong, Korea’s founding father of modern medicine.

SNUCM produced its first graduates in 1947, thereby laying the foundation for Korea’s modern medicine.

Song Chon Ji Seok-yeong, Principal of National Medical school

1899

1902

1908

HISTORY National Medical School opened / Ji Seok-young was the school’s first principal / Kim Ik-nam was the first instructor

6

First commencement ceremony of the National Medical School was held / 19 certified doctors were produced

Kim Ik-nam and other graduates of the National Medical School formed the Doctors’ Association/Parent organization of the Korean Medical Association

SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE Daehan Hospital Main Building (Clock Tower) 1 9 0 7

Daehan Hospital Operating Room 1 9 0 7

First Diploma of Graduation at SNUCM 1 9 4 7

SNUCM Main Building 1 9 4 6

1946

Two Seoul Medical Colleges were merged to form SNUCM

1947

First commencement ceremony of SNUCM was held

1952

SNUCM’s first six Ph.D.’s in medicine were awarded

1954-61

Minnesota Project was launched and completed

7

History

Multi-Disciplinary Laboratory opend 1 9 7 5

Kim Soo Tae, Liver transplantation 1 9 8 8

Since Seoul National University College of Medicine first opened in 1946, we set a goal to develop competent qualified doctors.

As a result, we have produced extremely talented and dedicated medical professionals.

Taking pride in shouldering the grave responsibility of bearing the future of Korea’s medicine with our school’s future, we are spearheading the advancement of Korea’s medicine

The first successful birth through in vitro fertilization in Korea 1 9 8 5

1963

Korea’s first successful open-heart surgery using a heart-lung machine was performed

8

1972

The Institute of Reproductive Medicine and Population opened

1974

The Medical Library was opened

1975

The MultiDisciplinary Laboratory (MDL) opened

1976

The Museum of Medicine opened

1977

World’s first hepatitis B vaccine was developed

Trailblazer for Advancing Medical Science Global medicine to Korea, Korean medicine to the World!

Seoul National University College of Medicine is soaring to the top ranks of the world’s foremost medical research and educational institutions.

Seoul National University College of Medicine strives to exceed its current successes, will continue to blaze new trails, and make its mark as a global leader in the field of medicine.

1978

Seoul National University Hospital (SNUH) was established as a special corporation

1984

The Liver Research Institute opened

1985

The Children’s Hospital opened

1990

The Research Building opened

1994

Korea’s first successful remote cardiac transplantation performed

1999

New dormitory building opened

9

History

SNUCM is a promise towards the future of medicine through the cultivation of world-class medical professionals.

We strive to cultivate a new generation of international health care providers with a solid educational foundation based on empathy and communication, securing a vibrant future for the health care industry.

Establishment of the Convergence Research Building 2 0 1 6

2003

A new Cancer Research Institute opened / Dr. Lee Jong-wook was elected Director-General of WHO

10

2007

Department of Biomedical Sciences was established

2008

SNU Biomedical Science Building opened

2012

Institute for Health and Unification Studies and JW LEE Center for Global Medicine opened

2013

Ji Seok-yeong Center (Clinical Training Center) and Health Quotient Center opened

SNUCM is soaring high in the world.

2018 QS World University Rankings Ranked 42nd in Medical Field (4th in Asia)

2014

Protein Metabolism Medical Research Center and Wide River Institute of Immunology established

2015

Commemoration ceremony of 116th year anniversary of the first medical school in Korea.

Announcement of the new education program

2016

The 100th anniversary of Kyung Sung Medical School.

The 90th anniversary of the foundation of Medical Department in Kyung Sung University.

Establishment of the Convergence Research Building

11

SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE Our Mission Development of the finest medical scientists to tackle the problems of health care.

Cultivation of leaders in the industry with the highest skills in medical research.

Production of humanitarian doctors contributing toward the betterment of humanity.

12

Part. 1

Strengthening the Future of Health Care

Education and Research

Seoul National University College of Medicine

14

15

Part. 1

Education The core educational principles of SNUCM are built upon a foundation of respect for humanity.

Conducting creative scientific research

Promoting health and relieving the pain and suffering of disease Educational Goals

SNUCM aims to produce graduates with the following capabilities and qualifications Acting ethically and professionally, with a focus on service

Leading society with an international perspective

Seoul National University College of Medicine Educational Course

01

Premedical Course (2Years)

02

College of Medicine (4Years)

03

Graduate School

At SNUCM, the foundational education on medicine is reinforced by character growth, leadership skills, and altruistic principles. Through such efforts, we strive to develop the proper clinical skills in our students to correctly diagnose and treat patients, as well as developing researchers and medical scientists to fight the diseases that ail humanity. SNUCM continues to support the advancement of medical science and technology by encouraging communication and collaboration across all the various departments. We believe that this philosophy will be the engine that drives the future of the global health.

16

01

Premedical Course

The Premedical Course encourages close collaboration and integration among the Medicine, Natural Sciences, Engineering, and the Social Sciences, leading to a synergy that will help strengthen the performance of future doctors.

•Educational Principles The Premedical Course recognizes the diverse backgrounds of each student and allows a degree of freedom that will bolster responsibility and self-motivation. The students will build upon their own strengths and weaknesses, nurturing them to become independent thinkers by self-directed learning.

01

02

03

04

Encouraging self-

Expanding social and

directed learning by

human science courses

Building communal ties

between students

offering a diverse

in order to lay down a

and leadership skills

and faculty in order to

options for courses

firm foundation in ethical

through various support

encourage self-motivation

and levels.

principles for the future.

programs.

and pride.

Developing close ties

•Educational Goals and Skill Sets Goals

Skill Sets

Critical skills to understand individuals and society

•Foundational knowledge of the Arts and Culture

•Analytical grasp on Historical, Social, and Economical issues

•A respect and understanding of diversity

•Recognition and practice of social responsibilities

Comprehensive knowledge of science and technology

•Foundational Knowledge of Natural Science

•Foundational Knowledge of Biomedical Science

•Foundational Knowledge of Mathematics

•Foundational Knowledge of Engineering

Fitness and overcoming adversity

•Strengthening overall fitness

•Balancing mind and body

•Overcoming adversity through teamwork

•Self-development through cultural activity

Communication skills within an intellectual community

•Logical thinking and expressive competency

•Deductive reasoning and problem solving skills

•Understanding and involvement in knowledge creation

•Global communication skills 17

Part. 1

Eduction on humanities for comprehensive understanding of disease

Human

Society

and patients

02

College of Medicine Seoul 2016 Lee Jong-Wook Curriculum

•Human – Society – Medicine The final objective of Human – Society – Medicine is to foster the knowledge and attitude needed in order to grow as a professional health care provider. Through the curriculum, students should seek ethical and moral conscientiousness, empathy, emotional and behavioral self-control, communication skills, communal understanding, social responsibility, critical thinking and problem solving, broad insights and respect for diversity. The program is made up of six areas, which includes Understanding of Humanity, Medical Ethics, Doctors and Society, Self-Development and Leadership, preventive and Environmental Medicine, and International Healthcare. These are taught in block courses for 1- 2 weeks each semester. The main difference in curriculum with other institutions is the fusion of all six areas throughout the curriculum. In addition, discussion groups are activated to promote self- motivated learning, subleting big class lectures.

18

Medicine

•Medical Research Program

Medical Research ➊

Advanced Elective Courses

Near the end of the freshman year, a

For six-weeks during the senior year,

The Medical Research Program spans

two-week Medical Research 1 class

students are offered a wide variety of

the entire 4-years in order to strengthen

teaches students Medical Statistics,

Advanced Elective Courses with the

medical research skills.

Research Ethics, and Laboratory

purpose of widening future options and

Safety Education, so that they will

give students a chance to experience

have a firm foundational understanding

fields outside their main curriculum.

for the basic and clinical research.

Medical Research ➊

Medical Research ➋ Mentor-Mentee relationship For a ten-week period In the sophomore year, each student is matched with a professor to allow one-on-one correspondence through regular research meetings and discussions. The students are given the opportunity to work on their own research

Medical Research ➋

projects in order to gain hands-on experience.

Autonomous research performance By participating in medical research, the students run through the entire process themselves, from framing hypotheses, designing research protocols, acquiring analysis skills, formulating conclusions, and writing research papers. Through this process, even

Advanced Elective Courses

students can build up fundamental ability as a scientist and leading clinician.

The Cultivation of Medical Scientists to be the Future Leaders of the Health Industry

19

Part. 1

Cultivate self-motivated education within students in clinical medicine and other fields.

03

Graduate School

•Overview Basic Medical Science Anatomy, Pathology, Microbiology and Immunology, Preventive, Parasitology and Tropical Medicine, History of Medicine & Medical Humanities, Forensic Medicine, Health Policy and Management, Biomedical Engineering, Medical Education

Department of Medicine

Clinical Science Internal Medicine, Surgery, Pediatrics, Obstetrics and Gynecology, Orthopaedic Surgery, Urology, Otorhinolaryngology-Head & Neck Surgery, Thoracic and Cardiovascular Surgery, Neurosurgery, Psychiatry, Ophthalmology, Dermatology, Radiology, Anesthesiology and Pain medicine, Plastic & Reconstructive Surgery, Radiation Oncology, Laboratory medicine, Rehabilitation medicine, Nuclear Medicine, Family Medicine, Emergency Medicine Translational Medicine

Based on 2018 Medical Majors

Physiology & Neuroscience Molecular Medicine & Oncology

Department of Biomedical Sciences

Systems Medicine, Informatics and Precision Medicine Immunology Biomedical Imaging

Department of Clinical Medicine Sciences – Interdisciplinary Programs: Cancer Biology / Clinical Pharmacology and Therapeutics / Medical Informatics / Stem-Cell Biology 20

21

Part. 1

Advanced Education for Clinician-Scientists •Basic Research Training Program for M.D. The SNUCM has been operating the Basic Research Training Program for M.D. to foster the next generation of leading medical researchers.

The Program combines training in basic science and clinical medicine. SNUCM provides financial support and a guarantee of status for the trainees to stable the atmosphere for education.

Purpose of Establishment ➊ Combined training in basic science and clinical medicine

for the next generation of leading medical scientists. ➋ Stable environment for academic pursuits. ➌ Steady flow of trained medical scientists with advanced skills

in basic research, clinical application, and Industrialization through advance of biomedical science.

22

Educational Goals

Creative thinking to identify novel issues Health care professionals must be

Data analysis abilities using diverse research methodology are

able to identify and understand new

capabilities for data analysis

problems that continue to rise with the

and diverse research methodology

advancement of international

are essential to diagnose and solve

biomedical field.

new problems.

Continuous research activities and acquisition of new knowledge

Contributions towards welfare and the improvement of human health

Through continuous research and

A sense of duty must be instilled towards

the acquisition of new knowledge,

improving welfare and the overall health

medical scientists will be able to gain

of humankind to further advancements

global competitiveness.

in Biomedical Science.

23

Part. 1

Research Training future generations of medical scientists on state-of-art technology and creativity.

The ultimate goal of medical research is to identify the causes and mechanism of diseases and to develop innovative technology to prevent, diagnose, and cure diseases.

24

Main Research Centers

Research Facilities Cancer Research Institute Liver Research Institute SNU Institute on Aging Wide River Institute of Immunology Institute of Reproductive Medicine and Population Institute of Endemic Diseases Neuroscience Research Institute Institute of Medical and Biological Engineering, Medical Research Center Institute of Environmental Medicine Institute of Radiation Medicine Genomic Medicine Institute Institute of Allergy and Clinical Immunology Laboratory of Transplantation Immunology Institute of Human Behavioral Medicine Institute of Human Environment Interface Biology Institute of forensic science Sensory Organ Research Institute Institute of Health Policy and Management Kidney Research Institute Ischemic/Hypoxic Disease Institute

Core Labs Biomedical Center for Animal Resource Development Core Research Facilities Medical Research Collaborating Center Institute for Experimental Animals

Hongcheon Research Institute

Liver Research Institute

Cancer Research Institute

25

Part. 1

Research Goals

The ultimate goal of research at the SNUCM is the development of innovative fundamental technology and treatment techniques to enter clinical practice for treatment of patients. With ongoing financial support of the government and the hard work of our professors, the university is proud to be ranked the 1st in both the number of research papers published each year and the amount of research funding among medical colleges in Korea. The influence of these research outcomes outstands across the globe through various kind of contribution, helping educate students and treating patients.

Unit: Persons

2018.3.1. Standard

Researchers by status

Faculty

Student College of Medicine Students

Graduate Students

Researcher / Staff

Premedical Course Students

875

517

26

Clinical Science

412

Basic Science

105

4th Year

152

3rd Year

154

905 618

2nd Year

156

1st Year

162

2nd Year

107

1st Year

144

Masters Program

487

Staff

175

PhD Program

418

Researcher

443

2017 Annual Statistics

$ 232.1 million

Research Fund Amount

Total Research Papers Published

Top In Korea

2797

Papers published in high impact journals* * Thomson impact factor > 10.0

141

The New England Journal of Medicine The Journal of The American Medical Association Immunity Cancer Cell The

n e w e ng l a n d j o u r na l

of

m e dic i n e

original article

Tofacitinib versus Methotrexate in Rheumatoid Arthritis Eun Bong Lee, M.D., Roy Fleischmann, M.D., Stephen Hall, M.D., Bethanie Wilkinson, Ph.D., John D. Bradley, M.D., David Gruben, Ph.D., Research Tamas Koncz, M.D., Sriram Krishnaswami, Ph.D., Gene V. Wallenstein, Ph.D., Chuanbo Zang, Ph.D., Samuel H. Zwillich, M.D., and Ronald F. van Vollenhoven, M.D., Original Investigation for the ORAL Start Investigators*

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors vs Conventional Chemotherapy in Non–Small Cell Lung Cancer Harboring Wild-Type Epidermal Growth Factor Receptor A Meta-analysis

A bs t r ac t Background

Methotrexate is the most frequently used first-line antirheumatic drug. We report the From Seoul National University College findings of a phase 3 study of monotherapy with tofacitinib, an oral Janus kinase inhibi- of Medicine, Seoul, South Korea (E.B.L.); Metroplex Clinical Research Center, Dallas tor, as compared with methotrexate monotherapy in patients with rheumatoid arthritis (R.F.); Cabrini Health and Monash University, Melbourne, VIC, Australia (S.H.); June-Koo Lee, MD; Seokyung Hahn, PhD; Dong-Wan Kim, MD, PhD; Koung Jin Suh, MD; Bhumsuk Keam, MD; who had not previously received methotrexate or therapeutic doses of methotrexate.

Groton,Lee, CT MD, (B.W., J.D.B., D.G.,Heo, S.K.,MD, PhD Tae Min Kim, MD,Pfizer, PhD; Se-Hoon PhD; Dae Seog

Methods

Immunity

G.V.W., C.Z., S.H.Z.); Pfizer, New York

Article

We randomly assigned 958 patients to receive 5 mg or 10 mg of tofacitinib twice (T.K.); and Karolinska Institute, Stockholm Supplemental content at Address reprint requests to Dr. daily or methotrexate at a dose that was incrementally increased to 20 mg perIMPORTANCE week (R.F.V.). jama.com Current at guidelines recommend both epidermal growth factor receptor (EGFR) Wilkinson Pfizer, 445 Eastern Point Rd., over 8 weeks; 956 patients received a study drug. The coprimary end points atkinase tyrosine (TKIs) andGroton, cytotoxic chemotherapy drugs as standard treatment Bldg.inhibitors 98, MS 8260-2517, CT 06340, options with wild-type (WT) EGFR who were previously treated for non–small cell month 6 were the mean change from baseline in the van der Heijde modified totalfor patients or at bethanie.wilkinson@pfizer.com. lung cancer (NSCLC). However, it is not clear that EGFR TKIs are as efficacious as Sharp score (which ranges from 0 to 448, with higher scores indicating greater * A in complete investigators in the chemotherapy patientslist withofWT EGFR. structural joint damage) and the proportion of patients with an American College ORAL Start study is provided in the Suppleof Rheumatology (ACR) 70 response (≥70% reduction in the number of both tender mentary Appendix, available at NEJM.org.

OBJECTIVE To determine the association between first-generation EGFR TKI vs and swollen joints and ≥70% improvement in three of five other criteria: the pa- N Engl 2014;370:2377-86. chemotherapy andJ Med survival in advanced NSCLC patients with WT EGFR. tient’s assessment of pain, level of disability, C-reactive protein level or erythrocyte DOI: 10.1056/NEJMoa1310476 Copyright © 2014EMBASE, Massachusetts Medical Society. sedimentation rate, global assessment of disease by the patient, and global assessDATA SOURCES PubMed, Cochrane database, and meeting abstracts Sang-Uk of the Seo,1 Nobuhiko Kamada,2 Raúl Muñoz-Planillo,1 Yun-Gi Kim,1 Donghyun Kim,1 Yukiko Koizumi,1 Mizuho Hasegawa,1 Stephanie D. Himpsl,3 Hilary P. Browne,4 Trevor D. Lawley,4 Harry L.T. Mobley,3 Naohiro Inohara,1 American Society of Clinical Oncology and European Society of Medical Oncology through ment of disease by the physician).

Distinct Commensals Induce Interleukin-1b via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury Cancer Cell

Article

and Gabriel Núñez1,*

December 2013.

Results

1Department

of Pathology and Comprehensive Cancer Center

2Division of Gastroenterology, Department of Internal Medicine Mean changes in the modified total Sharp score from baseline to month 6 were sigSTUDY SELECTION Eligible studies were randomized controlled trials comparing3Department EGFR TKI of Microbiology and Immunology nificantly smaller in the tofacitinib groups than in the methotrexate group, but changes with conventional chemotherapy in patients with advanced NSCLC. Out of 1947 retrieved The University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA were modest in all three groups (0.2 points in the 5-mg tofacitinib group and <0.1articles, point11 trials incorporating 1605 patients with WT EGFR were included. 4Bacterial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK in the 10-mg tofacitinib group, as compared with 0.8 points in the methotrexate group *Correspondence: gabriel.nunez@umich.edu DATA EXTRACTION AND SYNTHESIS Two reviewers extracted trial characteristics and [P<0.001 for both comparisons]). Among the patients receiving tofacitinib, 25.5% in http://dx.doi.org/10.1016/j.immuni.2015.03.004 outcomes. the 5-mg group and 37.7% in the 10-mg group had an ACR 70 response at month 6, as The risk of bias was evaluated using the Cochrane tool. All measures were pooled using random-effects models and 95% CIs were calculated. compared with 12.0% of patients in the methotrexate group (P<0.001 for both com5,12 VOL U MYang-Soon E 34 NU M B E6RYanghee 34 DKim, EC E1 MSo B E Hee R 1 ,Nam, 2 0 116 Jinkuk Kim,1,3,12 In-Hee Lee,1,2,12 Hee Jin Cho,1,4,12 Chul-Kee Park, Jung, SUMMARY are hyporesponsive to bacterial Toll-like receptor ligands such parisons). Herpes zoster developed in 31 of 770 patients who received tofacitinibMAIN (4.0%) Byung Sup Kim,6 Mark D. Johnson,8 Doo-Sik Kong,6 Ho Jun Seol,6 Jung-Il Lee,6 Kyeung Min Joo,1,4,7 Yeup Yoon,1,4 OUTCOMES AND MEASURES The primary outcome was progression-free survival (PFS), as lipopolysaccharides (Lotz et al., 2006; Smythies et al., Woong-Yang Park,1,2,4 Jeongwu Lee,11 Peter J. Park,9,10,13,* and Do-Hyun Nam1,4,6,13,* and in 2 of 186 patients who received methotrexate (1.1%). Confirmed cases of measured cancer as hazard ratios (HRs). The secondary outcomes were objective response rate and The microbiota stimulates inflammation, but the sig- 2005). In addition, several barriers including the mucus layer 1Samsung JOURNAL OF CLINICAL ONCOLOGY Biomedical Research Institute (including three cases of lymphoma) developed in 5 patients who received tofacitinib

Spatiotemporal Evolution of the Primary Glioblastoma Genome •

overall survival, expressed as relative risks and HRs, respectively.

naling pathways and the members of the microbiota

and in 1 patient who received methotrexate. Tofacitinib was associated with increases involved remain poorly understood. We found that with microbiota induces interleukin-1b (IL-1b) release in creatinine levels and in low-density and high-density lipoprotein cholesterolRESULTS levels. Among patients with WT EGFR tumors, chemotherapy was associatedthe improvement of PFS, compared with TKI (HR for TKI, 1.41; 95% CI, 1.10-1.81). Noupon statistically intestinal injury and that this is mediated Author Affiliations: Department of significant subgroup difference was identified in terms of line of treatment (first-line vs NLRP3 inflammasome. via the Enterobacteriaceae

Conclusions

Internal Medicine, Seoul National In patients who had not previously received methotrexate or therapeutic doses ofsecondmeth-or later-line), experimental drug, dominant ethnicity, or EGFR mutationand analysis in particular University the pathobiont mirabilis, Hospital, Seoul,Proteus Republic otrexate, tofacitinib monotherapy was superior to methotrexate in reducing signs and Trials using more sensitive platforms than direct sequencing were associated method. withrobust a of Korearelease (J.-K. Lee, D.-W. Suh, comparable induced IL-1b thatKim, was Keam, T.M. Kim, S.-H. Lee, Heo); significant symptoms of rheumatoid arthritis and inhibiting the progression of structural joint PFS benefit with chemotherapy (HR for TKI, 1.84; 95% CI, 1.35-2.52).toThe that induced by the pathogen Salmonella. Upon Medical Research Collaborating association or injury, production epithelial of IL-1b in the intestine damage. The benefits of tofacitinib need to be considered in the context of the risks of of chemotherapy with improvement in PFS was also significant in secondCenter, Seoul National University later-line trials (HR, 1.34; 95% CI, 1.09-1.65). The objective response rate was higher was with largely mediated intestinal Ly6Chigh monoHospital,by Seoul, Republic of Korea adverse events. (Funded by Pfizer; ORAL Start ClinicalTrials.gov number, NCT01039688.)

(Hahn); Department of Medicine, chemotherapy (92/549, 16.8%, vs 39/540, 7.2%, for TKI; relative risk for TKI, 1.11; 95% CI, cytes, required chemokine receptor CCR2 and was Seoul National University College of 1.02-1.21); however, no statistically significant difference was observed with respect to overall abolished by deletion of IL-1b in CCR2+ blood mono2377 n engl j med 370;25 nejm.org june 19, 2014 Medicine, Seoul, Republic of Korea survival (HR for TKI, 1.08; 95% CI, 0.96-1.22). cytes. Furthermore, colonization with P. mirabilis (Hahn); Cancer Research Institute, The New England Journal of Medicine Seoul National University College of promoted intestinal inflammation upon intestinal Medicine, Seoul, Republic of Korea Downloaded from nejm.org at Seoul National University on June 21, 2018. For personal use only.

No other uses without permission.

CONCLUSIONS AND RELEVANCE Among patients with advanced NSCLC harboring WT EGFR, injury via the production of hemolysin, which (D.-W. Kim, Keam, T.M. Kim, S.-H. Copyright © 2014 Massachusetts Medical Society. All rights reserved. conventional chemotherapy, compared with first-generation EGFR TKI, was associated with required NLRP3 and IL-1 receptor signaling in vivo.

Lee, Heo). improvement in PFS but not overall survival.

Thus, upon intestinal injury, selective members of Corresponding Author: Dong-Wan

the microbiota stimulate newly recruited monocytes Kim, MD, PhD, Department of Internal Medicine, Seoul National to induce NLRP3-dependent IL-1b release, which University Hospital, 101 Daehak-ro, promotes inflammation in the intestine.

Jongno-gu, Seoul 110-744, Republic of Korea (kimdw@snu.ac.kr).

JAMA. 2014;311(14):1430-1437. doi:10.1001/jama.2014.3314

INTRODUCTION

1430

jama.com

The intestine is inhabited by trillions of resident bacteria that can Copyright 2014 American Medical Association. All rights reserved.

Downloaded From: by a College of Medicine of Seoul National Univ. User on 05/29/2018

provide beneficial effects to the host (Kamada et al., 2013). For example, bacterial metabolites including vitamins and shortchain fatty acids contribute to appropriate development of the host. Resident bacteria also confer resistance against pathogen infection and are critically involved in the development of lymphoid populations in the intestine (Kamada et al., 2013).

Because commensal bacteria can stimulate the immune system, the host has evolved several mechanisms to prevent inappropriate activation of inflammatory responses in the intestine. For instance, the intestinal epithelium and resident macrophages 744 Immunity 42, 744–755, April 21, 2015 ª2015 Elsevier Inc.

•

O R I G I N A L

R E P O R T

and antimicrobial peptides limit the contact between microbes 2Samsung Genome Institute and the hostSamsung immuneMedical system Center, and contribute to gutKorea homeostasis Seoul 06351, 3Samsung (Kamada and Núñez, 2014).

A role for the eliciting Electronics Co., Ltd., Seoul 06351, Korea Advanced Institute of microbiota Technology,inSamsung 4Department of Health Sciences and Technology, Samsung Advanced Institute for Health Science and Technology (SAIHST), Sungkyunkwan intestinal inflammation is supported by findings that chemiUniversity, Seoul 06351, Korea cally-induced and spontaneous colitis are reduced or abolished 5Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 06351, Korea in antibiotic-treated mice and germ-free mice (Garrett et al., 6Department of Neurosurgery, Samsung Medical Center 2007; Hudcovic et al., 2001; Kirkland et al., 2012; Kitajima 7Department of Anatomy and Cell Biology et al., 2001; Vijay-Kumar et al., 2007). In mouse models, certain Sungkyunkwan University School of Medicine, Seoul 06351, Korea members of8 the microbiota have been linked to inflammatory reDepartment of Neurosurgery sponses and intestinal pathology. For example, Bacteroides 9Division of Genetics Sang Min Park, Young Ho Yun, Young Ae Kim, Minkyung Jo, Young-Joo Won, Joung Hwan Back, and species andBrigham members ofWomen’s the Enterobacteriaceae family including and Hospital, Boston, MA 02115, USA Eun-Sook Lee 10Department Klebsiella pneumoniae and mirabilis can promote of Proteus Biomedical Informatics, Harvardcolitis Medical School, Boston, MA 02115, USA 11Department (Bloom et al., 2011; Garrett et al.,Cell 2010).

However, the signaling of Stem Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA 12Co-first author Sang Min Park and Young Ho Yun, Seoul pathways by which resident bacteria stimulate the host immune A B S T R A C T 13Co-senior author National University College of Medicine; system to induce inflammation in vivo remain poorly understood.

Joung(D.-H.N.) Hwan Back, National Health peter_park@harvard.edu (P.J.P.), nsnam@skku.edu A critical *Correspondence: step in the activation of inflammatory responses is Purpose Insurance Service, Seoul; Young Ae Kim, http://dx.doi.org/10.1016/j.ccell.2015.07.013 the recognition of microbes or endogenous molecules produced Male cancer survivors have a higher risk of cancer than the general population, which might be Minkyung Jo, Young-Joo Won, and in the setting of infection or cellular injury by host pattern-recogEun-Sook Lee, National Cancer Center, caused by an increased prevalence of obesity or susceptibility to obesity-related carcinogenesis. We nition receptors (Takeuchi and Akira, 2010). A major innate Goyang, Republic of Korea. assessed the effects of obesity before the diagnosis of a first cancer on the development of signaling pathway is the inflammasome, a multi-protein platform Published online ahead of print at SUMMARY secondary primary cancers (SPCs). that activates caspase-1 leading to the proteolytic processing of www.jco.org on October 10, 2016. pro-interleukin-1b (IL-1b) and pro-IL-18 into their mature active Methodsmultiforme (GBM) Tumor recurrence following treatment is the majorSupported causebyofNational mortality for glioblastoma Cancer Center The study population consisted of 239,615 Korean male cancer survivors between January 2003 and forms (Schroder and Tschopp, 2010). To date, four bona fide Grant 1310252 and 1532200. patients. Thus, insights on the evolutionary process atNos. recurrence are critical for improved patient care. inflammasomes have been described, of which three, the December 2010. Incident SPCs were assessed throughout follow-up until December 2011. Cox Here, we describe our genomic analyses of the initial recurrent disclosures of potentialtumor conflicts specimens from each of 38 Authors’and NLRP1, NLRP3 and NLRC4 inflammasomes, contain a member proportional hazards models were used to calculate the hazard ratios of SPCs associated with of interest are in thealterations article online at was associated with distant GBM Nod-like patients.

A substantial divergence in the landscape offound driver of the intracellular receptor (NLR) family (Franchi et al., prediagnosis body mass index (BMI), which were compared with those of first cancers in all cohort www.jco.org. Author contributions are appearance of a recurrentNLRP3 tumoris from theby initial tumor, suggesting that the genomic profile of the initial tumor 2012b). Among the NLR inflammasomes, activated participants. found at the end of this article. can including mislead bacterial targetedpore-forming therapies toxins, for theATP, distally recurred tumor. In addition, in contrast to IDH1-mutated multiple stimuli Corresponding author: Eun-Sook Lee, Results gliomas, IDH1-wild-type primary et GBMs rarely developed hypermutation following temozolomide (TMZ) treatmicrobial RNA, and particulate matter (Hornung al., 2008; MD, PhD, National Research Institute, Kei Muro*,we Hyunobserved Cheol Chung, 4,799 Veena Shankaran, Geva,SPC. Daniel Catenacci, Shilpa Gupta, Joseph Paul Eder, Talia Golan, Dung T Le, 1,614,583 person-years of follow-up, patientsRavit with The ageMariathasanment, et al.,indicating 2006). In low contrast, NLRC4 activation ishypermutation risk for TMZ-induced for these tumors under After the standard regimen.

National Cancer Center, 323 Ilsan-ro, Burtness, Autumn J was McRee,1.1 Chia-Chi Lin, higher Kumudu Pathiraja, Jared Kenneth Emancipator, Jonathan Juco, Minori Koshiji, standardized incidence rate of cancer Barbara in cancer survivors times than that ofLunceford, the induced by several Gram-negative pathogens by the translocaIlsandong-gu, Goyang-si, Gyeonggi-do Yung-Jue general population. We found positive linearBang* trends between prediagnosis BMI and risk of alltion of small amounts of flagellin or PrgJ-like rod proteins into

Prediagnosis Body Mass Index and Risk of Secondary Primary Cancer in Male Cancer Survivors: A Large Cohort Study

Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre,ORIGINAL open-label, RESEARCH ARTICLE phase 1b trial

Exploring Coronary Circulatory Response to Stenosis and Its Association With Invasive Physiologic Indexes Using Absolute Myocardial Blood Flow and Coronary Pressure Letter

10408, Korea; e-mail: eslee@ncc.re.kr.

combined, colorectal, liver, lymphoma, biliary tract, kidney, and obesity-related SPCs. The magnithe host cytosol (Franchi et al., 2006; Miao et al., 2010). In the © 2016

by American Clinical INTRODUCTION onset.

MoreSociety than of90% of GBMs present as de novo GBMs intestine, NLRC4-dependent IL-1b production is triggered by tude of the BMI-SPC risk association in Summary male cancer survivors was stronger than that for first cancers Oncology (primary GBMs), and the remainder progress from low-grade been In shown to be upregulated Salmonella in resident phagocytes, which contribute to host the general population, whereas the Background mean BMI Expression was similarofinPD-L1 both has groups. the severely obese in some patients with gastric cancer. As part of the Glioblastoma multiforme (GBM; World Health Organization0732-183X/16/3434w-4116w/$20.00 (grades I–III) gliomas (secondaryinGBMs).

The current therapeu2 phase 1b KEYNOTE-012 study, we aimed assess the(1.41; safety95% and activity of the anti-PD-1 antibody pembrolizumab in defense through the recruitment of neutrophils (Franchi et al., $ 30 kg/m ), the adjusted hazard ratios for SPCs among cancertosurvivors grade IV glioma) is the most common and most aggressive brainDOI: tics for GBM serve mostly ascategory palliative(BMI measures.

Despite 10.1200/JCO.2016.66.4920 patients PD-L1-positive recurrent or metastatic of the stomach or gastro-oesophageal junction.

2012a). The role of the NLRP3 inflammasome in intestinal CI, radiation, 1.15 to 1.74) were significantly higher than with those for first cancers among all cohort adenocarcinoma participants tumor (Furnari et al., 2007; Tanaka et al., 2013). GBMs can be aggressive treatment with surgery, and the alkylating (1.12; 95%always CI, 1.09 to 1.16; classified into two categories, on the basis of the history of tumor agent temozolomide (TMZ), GBM almost recurs, and Pheterogeneity , .01).

4116

© 2016 by American Society of Clinical Oncology

worldwide, with a high incidence in east Asia.1 Most cases, especially in the USA and Europe, are diagnosed at a late stage, and treatment options are mostly restricted to cytotoxic chemotherapy, which is associated with poor outcomes.2 Despite the availability of trastuzumab for

Downloaded from ascopubs.org by Seoul National University Medical Library on HER2-positive June 21, 2018 from 147.046.161.082 patients with disease and the approval of Copyright © 2018 American Society of Clinical All rights reserved. antibody ramucirumab as theOncology. anti-VEGFR2 monoclonal

a second-line therapy, there remains a need for effective treatment options for advanced gastric cancer.

PD-1 is a negative co-stimulatory receptor expressed mainly on activated T cells,6 which downregulates excessive immune responses by binding to its ligands, PD-L1 and PD-L2.7,8 PD-L1 is constitutively expressed in various tissues and can also be expressed in several tumour types, including gastric cancer.6,9–12 In tumour tissues, binding of PD-1 to PD-L1 inhibits effector T-cell function, leading to suppression of the antitumour immune response and enabling neoplastic growth.6,7 3–5

Lancet Oncology

Published Online May 3, 2016 http://dx.doi.org/10.1016/ S1470-2045(16)00175-3

OPEN doi:10.1038/nature20098

Joo Myung Lee, MD, MPH, PhD Doyeon Hwang, MD Sourasky Medical Center, factor for cancer in the general population,12-15 Jonghanne Park, MD indexes, according to different anatomic and hemodynamic lesion Findings Oct 23, 2013, Maybody 5, 2014, 39 patients for response by central Tel Aviv, Israel (R Geva MD); cancer screening andFromprevious studiesto on weight and SPCwere riskenrolled. 36 were evaluable of Chicago, Chicago, Jinlong Zhang, MD severity, have not been fullyUniversity demonstrated in patients with coronary artery assessment.

(22%,largely 95% CI 10–39) patients wereofjudged treatment have led to continuously increasing sur- Eight have been confined to survivors breastto have had an overall response at central review; IL, USA (D Catenacci MD); Yaliang Tong, MD disease. all responses were partial.

All 39 patients were included in the safety analyses. Five (13%) patients had a total of University of Minnesota, an incancer (CRC)17; there are vival,1,2 these advances have been offset by cancer16 or colorectal Jeong-Sun Seo1,2,3,4,5*, Arang Chee rhie1,2,3 *, Junsoo Kim1,4*, Sangjin Lee1,5*, Min-Hwan Sohn1,2,3, chang-Uk Kim1,2,3, Alex Hastie6, Hae Kim, MD six grade 3 or 4 treatment-related adverse events, consisting of two cases of grade 3 fatigue, one case each of grade 3 Minneapolis, MN, USA 6 1,5 1,5 1,5 1,5 1,5 4 4 4 creased risk of secondary primary cancers (SPCs). few studies about these associations among male , Ji-Young Yun , Jihye Kim , Junho Han cao (S Gupta MD);patients Yale University,with left anterior descending METHODS: Oneofhundred Ji-In Bang, MD Kuk , Gun Hwa Park , Juhyeok Kim , Hanna ryu , Jongbum Kim , Mira roh , pemphigoid, grade 3 hypothyroidism, and grade 3 peripheral sensory neuropathy, and one case grade 4 fifteen Jeonghun baek4, Michael W. Hunkapiller7, Jonas Korlach7, Jong-Yeon Shin1,5 & changhoon Kim4 New Haven, CT, USA Many previous studies have demonstratedpneumonitis. that the cancer survivors. In deaths addition, few studies have No treatment-related occurred.

Minseok Suh, MD emission artery stenosis who underwent both 13N-ammonia positron (J P Eder MD); Sheba Medical risk of developing an SPC among cancer survivors examined how obesity might contribute to inCenter, Ramat Gan, Israel Jin Chul Paeng, MD, PhD tomography and invasive physiological measurement were analyzed. might be as great as or greater than that among the creased SPC risk. Only one study, Gibson or et metastatic al,17 Interpretation In this population of patients withby recurrent PD-L1-positive gastric cancer, pembrolizumab (T Golan MD); Kimmel Cancer Gi phasing Jeong Cheon, MD, PhD provide an opportunity (Extended Data Fig. 2a). Reads were assembled and error-corrected Myocardial blood flow (MBF) measured with positron Advances emissionin genome assembly and not suggested that elevated cancer riskantitumour in survivorsactivity, of general population.3-6 SPCs could be due hadtoa manageable toxicity profi le and promising warranting further study in phase 2 and 3 trials. Center, Johns Hopkins to investigate the diploid architecture of theKoo, human genome Bon-Kwon MD, PhD and with FALCON and Quiver5 to generate 3,128 contigs with a contig Baltimore, MD, USA tomography and invasively University, measured coronary pressures were used to only the late carcinogenic effects of cancer treatment CRC compared with the general population might reveal the full range of structural variation across population N50 length of 17.9 Mb (Extended Data Table 1, Extended Data Fig. 2b (D T Le MD); Fox Chase Cancer calculate microvascular resistance and stenosis resistance. but also the influence of shared behavioral riskMerckbe&caused by an increased prevalence of obesity Funding Co. groups. Here we report the de novo assembly and haplotype phasing and Supplementary Tables 1–3). To anchor these contigs into larger Center, Philadelphia, PA, USA (B Burtness MD); University of of the Korean individual AK1 (ref. 1) using single-molecule real- scaffolds, we used next-generation mapping (NGM) from BioNano factors or increased susceptibility to carcinogenesis. rather than increased susceptibility to obesity2 Carolina Lineberger RESULTS: Withhigh-affi progressive worsening of angiographic stenosis severity, time sequencing , next-generation mapping3, microfluidics- Genomics Irys System, which produces physical maps with unique Introduction Pembrolizumab is a selective, humanised, nity North Among shared behavioral risk factors, most related tumorigenesis. However, in that study, Comprehensive Cancer Center, based linked reads4, and bacterial artificial chromosome (BAC) sequence motifs that can provide long-range structural information bothdesigned restingtoand transstenotic pressure gradient and stenosis IgG4-κ monoclonal antibody bindhyperemic to PD-1 Chapel the fiof fthsecondary most common cancer cancers studies have focused on the associationsGastric betweencancer the is number obesity-related Hill, NC, USA

www.thelancet.com/oncology Vol 17 June 2016

Downloaded from http://circ.ahajournals.org/ by guest on June 21, 2018

318 Cancer Cell 28, 318–328, September 14, 2015 ª2015 Elsevier Inc.

Journal of Clinical Oncology

Lancet Oncol 2016; 17: 717–26

Methods This study was a multicentre, open-label, phase 1b trial done at 13 cancer research centres in the USA, Israel, See Comment page 682 Conclusion Japan, South Korea, and Taiwan. We enrolled patients with PD-L1-positive recurrent or metastatic adenocarcinoma of *Contributed equally Prediagnosis obesity is a risk factor for andorindividual SPCs, andjunction. the strength of received the BMItheoverall stomach gastro-oesophageal Patients intravenous pembrolizumab at 10 mg/kg once every Cancer Center Hospital, cancer association is slightly stronger 2inweeks malefor cancer survivors than in the general population.

24 months or until progression or unacceptable toxic effects occurred. Response was assessed every 8 weeks Aichi Nagoya, Japan (K Muro MD); Significance in accordance with Response Evaluation Criteria in Solid Tumors version 1.1. The primary objectives were safety in Yonsei Cancer Center, Yonsei J Clin Oncol 34:4116-4124. © 2016 by American Society atofleast Clinical Oncology patients who received one dose of pembrolizumab and the proportion of patients achieving overall responses in University College of Medicine, Although previous sequencing studies examined the genomic landscape of GBMs and their evolution, they did not relate South Korea BACKGROUND: AlthoughSeoul, invasive physiological assessment for coronary patients who received at least one pembrolizumab dose and who either had a post-baseline scan or who discontinued genomic evolution patterns to tumor location or treatment regimens. Our integrative clinical and genomic analyses of 38 (Prof H C Chung MD); University 5,7-9 10,11 longitudinal pairs reveal that a recurrent tumor at a distant brain site from the initial tumor has a highly divergent genomic therapy because of clinical disease progression a treatment-related adverse event before the first post-baseline tobacco and alcohol useorand the risk of stenosis has become scan. a standard practice to guide treatment strategy, of Washington, Seattle, WA, profile compared with the initial tumor, suggesting that the location of recurrence should be considered whenINTRODUCTION using the The study is registered with ClinicalTrials.gov, NCT01848834, and is ongoing but no longercirculatory enrolling patients.

SPCs. Although obesity is a number well-known risk USA (V Shankaran MD); Tel Avivin invasive physiological coronary response and changes genomic profile of the initial tumor to guide targeted therapies for the recurrent tumor. Our study also demonstrates that IDH1-wild-type primary GBMs have low risk for TMZ-induced hypermutation following the standard regimen. These findings Although improvements in provide critical insights for informed clinical decisions.

Nature

Articles

De novo assembly and phasing of a Korean human genome

sequencing approaches. Single-molecule sequencing coupled with and thus block the interaction between PD-1 and its (A J McRee resistance increased (P<0.001 forMD); all)National and hyperemic MBF (P<0.001) next-generation mapping generated a highly contiguous assembly, Taiwan University Hospital, ligands.13 Pembrolizumab a manageable safety resistance andhas resting microvascular (P=0.012) decreased. with aResting contig N50MBF size of 17.9 Mb and a scaffold N50 size of 44.8 Mb, profile and has shown promising antitumour activity Taipei, Taiwan (C-C Lin MD); Merck & Co, Kenilworth,resistance NJ, (P=0.383) and hyperemic microvascular (P=0.431) resolvingwere 8 chromosomal arms into single scaffolds. The de novo in several types of advanced solid tumours and USA (K Pathiraja MA, assembly, along with local assemblies and spanning long reads, 14 not changed and maintained stable. haematological malignancies.

Pembrolizumab is J Lunceford PhD, Both fractional flow reserve and closesstenosis 105 and severity, extends into 72 out of 190 euchromatic gaps in K Emancipator MD, J Juco MD, instantaneous wave-freeof ratio decreased as angiographic approved in several countries for the treatment the reference genome, adding 1.03 Mb of previously intractable M Koshiji MD); and Seoul advanced melanoma andstenosis is approved in the USA and for the resistance, transstenotic gradient increased National Universitypressure College of sequence.

Highand concordance between the assembly and paired-end treatment of metastatichyperemic non-small-cell cancer (all Medicine, Seoul, South Korea MBFlung decreased P<0.001).

When the presence myocardial sequencesof from 62,758 BAC clones provides strong support for the that has progressed on or after platinum-containing (Prof Y-J Bang MD) robustness of the assembly. We identify 18,210 structural variants ischemia was defined by both low hyperemic MBF and low coronary chemotherapy and expresses PD-L1, as assessed with the Correspondence to: by direct comparison of the assembly with the human reference, flowkitreserve, the diagnostic of Center fractional flow reserve and Kei Muro, Aichi Cancer PD-L1 IHC 22C3 pharmDx (Dako North America, Dr accuracy Correspondence Bon-Kwon have identifying thousands of breakpoints that, to ourto: knowledge, Hospital, Nagoya 464-8681, instantaneous wave-free did not differ, regardlessnotofbeen cutoff values of ManyKoo, Carpinteria, CA, USA; approved by the US Food and ratio MD,insertions PhD, Department reported before. of the are reflected in Japan of Internal Medicine Drug Administration).13–15hyperemic MBF and coronary the transcriptome and are shared across the Asian and population. We flow reserve. kmuro@aichi-cc.jp Center, Findings from several studies support targeting of the performed haplotype phasing Cardiovascular of the assembly withSeoul short reads, National University Hospital, 101 and PD-1 pathway in gastric cancer.

Preclinical data suggest long readscirculation and linked reads from whole-genome sequencing CONCLUSIONS: This study demonstrated how the coronary Daehang-ro, Chongno-gu, Seoul, with short reads from 31,719 BAC clones, thereby achieving phased that PD-L1 expression changes is signifiin cantly upregulated response to increasing coronary stenosis severity using 110-744, Korea.

E-mail bkkoo@ blocks with an N50 size of 11.6 Mb. Haplotigs assembled from singlefollowing Helicobacter pylori infection and that the 13 N-ammonium positron emission tomography–derived MBF and invasively snu.ac.kr molecule real-time reads assigned to haplotypes on phased blocks resulting decrease in T-cell proliferation can be reversed measured pressure data. Currently used resting and hyperemic covered 89%pressure– of genes. The haplotigs Sourcesaccurately of Funding,characterized see page 1807the hypervariable major histocompatability complex region as well as derived invasive physiological indexes have similar patterns of relationships 717 Key Words: coronary artery demonstrating allele configuration in clinically relevant genes such to the different anatomic and hemodynamic lesion severities. disease fractional flow reserve, as CYP2D6. This work presents the most◼contiguous diploid human myocardial ◼ instantaneous wave genome assembly so far, with extensive investigation of unreported CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. free ratio myocardial ischemia and Asian-specific structural variants, and◼high-quality haplotyping Unique identifier: NCT01366404. ◼ myocardial perfusion imaging of clinically relevant alleles for precision medicine. tomography Although massively parallel ◼ positron-emission sequencing approaches have been widely used to study genomic variation, simple alignment of short © 2017 American Heart reads to a reference genome cannot be used to investigate the full Association, Inc. range of structural variation and phased diploid architecture, which are important for precision medicine. By contrast, the single-molecule real-time sequencingDOI: platform produces long reads that can Circulation. (SMRT) 2017;136:1798–1808.

10.1161/CIRCULATIONAHA.117.029911 1798 November 7, 2017 resolve repetitive structures effectively. We integrated this technology with several other sequencing approaches to construct a high-quality Korean diploid genome assembly (Extended Data Fig. 1).

SMRT sequencing of the genome of a Korean individual AK1, for whom we have previously reported the annotated variations assessed with BAC clones and array comparative genomic hybridization1, was performed at 101× coverage using Pacific Biosciences (PacBio) RSII

of the genome. Two rounds of NGM at 97× and 108× coverage were performed, with the second designed to protect fragments better from breakage at fragile sites, providing improved long-range anchoring (Supplementary Table 4). The optical maps were assembled de novo into genome maps. Hybrid scaffolding of the contigs and genome maps resulted in 2,832 scaffolds with a scaffold N50 size of 44.8 Mb (Extended Data Table 1 and Extended Data Fig. 3a). Because NGMs provide orders of magnitude longer range information (Supplementary Table 4) compared to long reads from the SMRT platform (Supplementary Table 1), we relied on the genome map when there were conflicts between the two datasets. Checks for consistency between genome maps and contigs corrected potential assembly errors within 23 contigs (Extended Data Fig. 3b and Supplementary Table 5). The final assembly after polishing with Illumina reads (Extended Data Fig. 4a) is characterized by marked contiguity that has not been achieved by non-reference assemblies of the human diploid genome6-8 so far, and improves on the previous best6 N50 length by 18 Mb (Table 1). The largest 91 scaffolds, for example, cover 90% of the genome and 8 chromosomal arms are spanned by single scaffolds (Fig. 1a).

The scaffolding accuracy of the AK1 assembly was assessed using paired-end sequences from AK1 BAC library1 from 62,758 BAC clones (Extended Data Fig. 1). Most (95.4%) of the uniquely aligned BAC clones were in concordance with the assembly (Extended Data Table 2), as expected since the genomic DNA originated from the same individual. From the set of BAC clones that aligned concordant with the reference genome, 99.8% also aligned concordant with the AK1 assembly, with most of the discrepancies caused by phase differences (Supplementary Table 6). The base accuracy of the assembly was assessed by Illumina short reads (72×). The read-depth distributions of the reads mapped to GRCh37, GRCh38 and AK1 show similar patterns (Extended Data Fig. 4b). The estimated base-level error rate of the assembly was less than 10−5 based on the count of single nucleotide polymorphisms (SNPs) with unexpected alleles (Extended Data Fig. 4c and Supplementary Table 7).

We used the AK1 assembly to close gaps remaining in human genome reference GRCh38. Of 190 euchromatic gaps (Supplementary Table 8), 65 were closed entirely by our de novo assembly (Fig. 1b and Extended Data Fig. 5). Local realignment and reassembly, and use of spanning reads, resolved a further 40 gaps. The closed gaps were

1

Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul 110-799, South Korea. 2Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 110-799, South Korea. 3Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110-799, South Korea. 4Bioinformatics Institute, Macrogen Inc., Seoul 153-023, South Korea. 5Genome Institute, Macrogen Inc., Seoul 153-023, South Korea. 6BioNano Genomics, San Diego, California 92121, USA. 7Pacific Biosciences of California, Inc., Menlo Park, California 94025, USA. *These authors contributed equally to this work.

1 3 O c t O b e r 2 0 1 6 | VO L 5 3 8 | NAt U r e | 2 4 3

© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Circulation

27

Part. 1

Campus Life Students create a lively campus culture and attractive atmosphere through the student union and student societies.

28

Extracurricular Activities CaSA

AMSA

Songchon Medical Volunteer Community

Easten Medicine Research Society

Ieaul Treatment Club (MFC) Coexist (Group) Gugu Treatment Club

Academic Soieties

Medical Volunteer Work

SNUCM supports the numerous extracurricular activities which

Sprout International Public Health Forum MD Winners

Ukkedongmu (Group)

MExIM

Seoul Undergraduate Hospice

Soundelight

Salt Society Hiking Club

Hobby

Art Club

Culture and Arts

Wine heart Theater Club PAIM PLAY Soccer Club Freeze

Tennis Club

Sports

Choir

Religion

including medical volunteer work, culture and arts, religion, academic pursuit, hobbies, and sports.

Student Council Seoul National University Student Council The student council consists of the regulatory division and legislative body, although the regulatory division is considered the main body of the student council. The regulatory division is Office, Information Office, PR Office, Culture and Welfare Office.

Rights Commission. Also, the student council oversees the yearly festival week, producing various programs for campaigning, welfare services and career exploration for the students.

Representatives for Each Class and Study Group Representatives for each class gather into groups and plan for the yearly events. In addition to that, the representatives are

Basketball Club

MOCA (A capella)

Yun-gun Christian Association

participate in 41 different societies in seven different fields

A special affiliated body is also underway to establish a Human Photography Club

Magic

CMF

efforts and leadership skills. Currently, students actively

divided into the Planning and Administrative Office, Financial

Arpegio Music Club

help to strengthen communal bonds and cultivate volunteering

Baseball Club Weight-lifting Club

responsible to communicate important information to the rest of the student body. Study groups allow greater learning through teamwork and cooperation.

Standing Committee The Standing Committee is a legislative organization, which was completely reshaped in 2017 by the Student Council, and is now

IVF (Korean Christian Student Association)

Volleyball Club

Yun-gun Bhuddist Association

Swim Club

Catholic Bible Reading Groupl

Table Tennis Club

made up of the Student Body President, the Undergraduate School Representative, the Pre-Medical Science Representative, and the Extracurricular Union President. The Standing Committee meets each week in conference and discusses proposals to better the needs of the student body.

29

Part. 2

Joining the World Through

Connection and Expansion

Seoul National University College of Medicine

30

31

Part. 2

Lee Jong Wook – Seoul Project Seoul National University College of Medicine transfers advanced medial technology and knowledge to the world.

'Minnesota Project' in the 1950s

In the 1950s, the ‘Minnesota Project’ was a catalyst to spur the rapid development of the Seoul National University College of Medicine. Half a century later, the Lee Jong Wook – Seoul Project gives us the opportunity to pay back that debt by sharing our advancements in medical technology with developing nations.

MOU with University of Health Sciences of Lao PDR in 2011

In 2011, SNUCM and University of Health Sciences of Lao PDR signed an MOU. SNUCM invites exchange students from Laos and provides medical equipment to their home country.

SNUCM is striving to meet its social responsibility by helping Laos improve its medical technology and welfare.

32

The Lee Jong Wook â&#x20AC;&#x201C; Seoul Project was created with the financial support of KOFIH (Korea Foundation for International Health). Planned to run from 2010 to 2020, the program is named after the late Lee Jong Wook, former Director-General of the WHO, famous for his lifelong dedication towards the advancement of the Third World countries health care. The locational naming scheme was inspired by the Minnesota Project. The program was started in 2009 after Korea obtained its DAC (Development Assistance Committee) membership within OECD (Organization for Economic Cooperation and Development), changing from a country which received aid to one that gave it out. This allowed us to pass on the vital financial aid that was received through the Minnesota Project to the developing nation of Laos. Starting with the first exchange student in 2011, the program will continue on into the present, boasting 68 Laos professors now trained and continuing into the future. The eighth program begins in April of 2018, ending on the ninth in 2020. In addition, SNUCM provides additional on-site advisors and consulting, as well as providing equipment, giving guest lectures, creating a long term relationship with Laos in order to lower the mortality rate and improve overall health standards.

33

Part. 2

JW LEE Center for Global Medicine Strengthening the Capacity Building

Congenital heart diseases (CHD) are treatable conditions if the diagnosis and the surgical intervention are provided in a timely manner. Nevertheless, due to the limited medical infrastructure and specialized health professionals for diagnosis and operation, many patients have been being left out from the benefit of the surgical treatment in countries where the ability of operation and patient care is limited.

This situation has motivated JW LEE Center for Global Medicine (CGM) of Seoul National University College of Medicine (SNUCM) to support in aspects of both physical infrastructure and human resource training to strengthen the capacity of countries for the cardiac surgery. The project has been conducted in several countries, including Ethiopia, Uzbekistan, Nepal, Mongolia, and China for several years.

We expect to see that the capacity of countries for cardiac surgery will raise enough to provide the surgical treatment to their patients without support from outside. Hence, all CHD patients should enjoy healthy lives.

Under close relationship and cooperation with governments and hospitals in developing countries, SNUCM educates local medical staffs through on-site and invitational training, particularly in the field of cardiac surgery. The training in Korea gives an opportunity for local medical staffs to be exposed to cutting-edge skills and knowledge of treatment and care for patients with CHD as well as to an advanced healthcare system. On-site training at local hospitals enables Korean staffs to supervise local health professionals in diagnosing, operating, and caring for patients. Overall, this project aims at enabling medical personnels in developing countries to treat patients with CHD on their own.

34

ETHIOPIA – Tikur Anbessa Specialized Hospital(TASH)

UZBEKISTAN – Tashkent Pediatric Medical Institute

35

Part. 2

Institute for Health and Unification Studies Institute for Health and Unification Studies has tried to build healthy community in Korean peninsula through reducing healthcare gap between North and South Korea by research and education programs.

Healthcare support projects and â&#x20AC;&#x2DC;Medicine and Korean Reunification Forumâ&#x20AC;&#x2122;

Preparing Inter-Korean Exchange and Cooperation and education and training program of public health manpower for unification

36

In 2008, Seoul National University Children’s Hospital and Okedongmu Children in Korea built a Pyongyang Okedongmu Children’s clinic and Pediatric Ward in Pyongyang Medical College Hospital, and provided training program for North Korean health professionals since 2009.

Based on the experiences, Institute for Health and Unification Studies(IHUS) was founded in 11th of June 2012 for not only understanding healthcare gap between North and South Korea also improving public health in North Korea to prepare a unification of Korean peninsula.

IHUS has focused healthcare in North Korea and healthcare in whole Korean peninsula because North and South Korea are strongly related to build a healthy society. IHUS has also focused training program of public health manpower for unification.

IHUS suggested healthcare R&D between North and South Korea because North and South Korea have their own strength in public health and it can help to reduce healthcare gap between two Koreas.

IHUS has provided manpower training program for citizens, practitioners, researchers, and experts on healthcare and unification. There are two kinds of manpower training programs, one is public lecture series called ‘Tong-Tong open lecture’, the other is academic program for young leaders called ‘Tong-Bo-Ri Academy’. These two training and education programs provide understanding on current health issues in North and South Korea such as One Health and Health Security topics.

Currently, IHUS is preparing healthcare cooperation with China, North and South Korea by considering change of situation in Korean peninsula. Through this approach, we expect to resume a training program for North Korean health professionals in Pyongyang Medical College and academic exchanges in public health.

37

Part. 2

International Partnerships Global Activities in International Health and Medicine.

International Exchange

The faculty members at SNUCM are leaders in domestic medical advancement, as well as showing incredible prowess within the international medical academia. By establishing MOUs and sharing knowledge with various domestic and international medical schools, students and professors are given more oppurtunities in the international exchange program so that the globalisation of medical education will rise beyond spatial and temporal boundary.

Unit: Persons

Status of Foreign Trainees Europe Oceania Asia Middle East North America Central America Africa

2013 2014

13

7

19

28

7

2015 2016 2017

44

7 1 49 19

43

8

12

38

17

96 22

64

2

100

1

106

14

15

2 99

23

172

2 3

16

14

210

SNUCM provides foreign students with practical training in hospitals and various knowledge exchange programs, bringing in more foreigners each year.

Unit: Persons

Status of students studying abroad in the last 3 years

151

32

29

74

6

Europe Oceania Asia

10

Middle East North America

SNUCM provides international education experience for students with the student exchange program, allowing a widening of perspective needed to become global leaders.

38

Signing MOU with International Institutions

EUROPE

country

continent

country

Institution name University of Hong Kong Li Ka Shing Faculty of Medicine

Canada

McMaster University

Hong Kong

Canada

University of British Columbia

Thailand

Thammasat University Faculty of Medicine

USA

University of California, Los Angeles(UCLA) David Geffen School of Medicine

Thailand

Chulalornkorn University Faculty of Medicine

USA

University of Southern California Keck School of Medicine

Thailand

Chiang Mai University Faculty of Medicine

USA

Temple University Of The Commonwealth System of Higher Education

Thailand

Mahidol University Faculty of Medicine

USA

Johns Hopkins University Bloomberg School of Public Health

Kazakhstan

Kazakh Medicine University

USA

University of Rochester Medical Center

Kazakhstan

Al-Farabi Kazakh National University

USA

University of Nebraska Medical Center

Kazakhstan

Astana Medical University

USA

George Washington University School of Medicine and Health Sciences

China

Harbin Medical University

USA

University of South Florida Morsani College of Medicine

China

Jilin University School of Public Health

USA

University of Chicago Medicine

China

Jilin Univesity Norman Bethune College of Medicine

USA

Michigan State University

China

Yanbian University College of Medicine

USA

New York University School of Medicine

China

Shanghai Jiao Tong University School of Medicine

USA

Rutgers-The State University of New Jersey (Biomedical)

China

Peking University Health Science Center

USA

University of Utah

China

Sun Yatďź?Sen University Zhongsan School of Medicine

USA

Columbia University(in the City of New York)

China

Tianjin Medical University /Tianjin Cancer Institute

USA

University of Pennsylvania Perelman School of Medicine

China

Peking Union Medical College

USA

Western University of Health Sciences

China

Yanda Group

USA

University of Texas, MD Anderson Cancer Center

China

Capital Medical University

USA

Rutgers-Robert Wood Johnson Medical School

Japan

Kyoto Prefectural University of Meidicne

USA

University of California, Irvine School of Medicine

Japan

University of Tokushima Faculty of Medicine

USA

Emory University School of Medicine

Japan

Tokyo Medical University

Hungary

Semmelweis University Faculty of Medicine

Japan

Tokyo Medical and Dental University Faculty of Medicine

Czech Republic

Charles University 2nd Faculty of Medicine

Japan

Kyoto University Faculty and Graduate School of Medicine

England

King's College London

Japan

Nagoya University Graduate School of Medicine

England

Liverpool School of Tropical Medicine

Japan

Osaka City University Faculty of Medicine

Spain

Universidad AutĂłnoma de Madrid School of Medicine

Japan

Osaka Medical College

Swiss

University of Basel Faculty of Medicine

Japan

Fujita Health University

Russia

I.M. Sechenov First Moscow State Medical University

Japan

Jikei University School of Medicine

Germany

University Medical Center Goettingen

Indonesia

Gadjah Mada University Faculty of Medicine

Germany

Goethe University of Frankfurt Medical Faculty

Netherlands

Maastricht University Faculty of Health, Medicine and Life Sciences

Singapore

Netherlands

University Medical Center Rotterdam Erasmus MC

Vietnam

Hanoi Medical University

Vietnam

175 Military Hospital at Ho Chi Minh City

Vietnam

The University of Medicine and Pharmacy at Ho Chi Minh City

Australia/ Domestic OCEANIA

Institution name

ASIA

NORTH AMERICA

continent

SNUCM promotes international student exchange programs and researchers academic activities in its MOU-bound active cooperation with a network of prestigious medical schools in Korea and overseas and associated international organizations, thereby continuing to bolster expansion of mutual exchanges.

University of South Australia, Quality Use of Medicine and Pharmacy Research Centre, Sansom Institute/Korea Institute of Drug Safety & Risk Management

Uzbekistan Ministry of Health via Republican Research Center of Emergency Medicine National University Singapore Yong-Loo Lin School of Medicine

Myanmar

University of Medicine 1 University of Health Sciences of Lao PDR

Australia

University of Melbourne

Laos

Australia

University of New South Wales

Taiwan

Kaohsiung Medical University

Australia

University of Sydney

Taiwan

National Taiwan University College of Medicine

New Zealand

University of Queensland School of Medicine

Taiwan

National Yang-Ming University School of Medicine

New Zealand

University of Auckland

Taiwan

Taipei Medical University College of Medicine

AFRICA

Ethiopia

St. Paul Hospital - KOFIH - Seoul University Hospital

Nepal

Kathmandu University School of Medical Sciences

ETC

Overseas

The World Health Organization(WHO/WPRO)-WHO West-Pacific Division

UAE

UAE University College of Medicine & Health Sciences

UAE

Sheikh Khalifa Specialty Hospital

39

Part. 2

SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE INTERNATIONAL PARTNERSHIPS

HUNGARY Semmelweis University Faculty of Medicine

CZECH REPUBLIC

HONG KONG

Charles University 2nd Faculty of Medicine

University of Hong Kong Li Ka Shing Faculty of Medicine

UNITED KINGDOM

THAILAND

King's College London Liverpool School of Tropical Medicine

Thammasat University Faculty of Medicine Chulalornkorn University Faculty of Medicine Chiang Mai University Faculty of Medicine Mahidol University Faculty of Medicine

SPAIN Universidad Autónoma de Madrid School of Medicine

SWITZERLAND University of Basel Faculty of Medicine

RUSSIA I.M. Sechenov First Moscow State Medical University

GERMANY University Medical Center Goettingen Goethe University of Frankfurt Medical Faculty

NETHERLANDS Maastricht University Faculty of Health, Medicine and Life Sciences University Medical Center Rotterdam Erasmus MC

40

AUSTRALIA University of South Australia, Quality Use of Medicine and Pharmacy Research Centre, Sansom Institute/한국의약품안전관리원 University of Melbourne University of New South Wales University of Sydney

NEW ZEALAND University of Queensland School of Medicine University of Auckland

ETHIOPIA St. Paul Hospital - KOFIH - Seoul University Hospital

KAZAKHSTAN Kazakh Medicine University Al-Farabi Kazakh National University Astana Medical University

CHINA Harbin Medical University Jilin University School of Public Health Jilin Univesity Norman Bethune College of Medicine Yanbian University College of Medicine Shanghai Jiao Tong University School of Medicine Peking University Health Science Center Sun Yat－Sen University Zhongsan School of Medicine Tianjin Medical University /Tianjin Cancer Institute Peking Union Medical College Yanda Group Capital Medical University

JAPAN

MYANMAR University of Medicine 1

LAO PDR University of Health Sciences of Lao PDR

TAIWAN Kaohsiung Medical University National Taiwan University College of Medicine National Yang-Ming University School of Medicine Taipei Medical University College of Medicine

NEPAL

Kyoto Prefectural University of Meidicne University of Tokushima Faculty of Medicine Tokyo Medical University Tokyo Medical and Dental University Faculty of Medicine Kyoto University Faculty and Graduate School of Medicine Nagoya University Graduate School of Medicine Osaka City University Faculty of Medicine Osaka Medical College Fujita Health University Jikei University School of Medicine

INDONESIA Gadjah Mada University Faculty of Medicine

UZBEKISTAN Ministry of Health via Republican Research Center of Emergency Medicine

SINGAPORE National University Singapore Yong-Loo Lin School of Medicine

Kathmandu University School of Medical Sciences

UNITED ARAB EMIRATES UAE University College of Medicine & Health Sciences Sheikh Khalifa Specialty Hospital

VIETNAM Hanoi Medical University 175 Military Hospital at Ho Chi Minh City The University of Medicine and Pharmacy at Ho Chi Minh City

CANADA McMaster University University of British Columbia

University of California, Los Angeles(UCLA) David Geffen School of Medicine University of Southern California Keck School of Medicine Temple University Of The Commonwealth System of Higher Education Johns Hopkins University Bloomberg School of Public Health University of Rochester Medical Center University of Nebraska Medical Center George Washington University School of Medicine and Health Sciences University of South Florida Morsani College of Medicine University of Chicago Medicine Michigan State University New York University School of Medicine Rutgers-The State University of New Jersey (Biomedical) University of Utah Columbia University(in the City of New York) University of Pennsylvania Perelman School of Medicine Western University of Health Sciences University of Texas, MD Anderson Cancer Center Rutgers-Robert Wood Johnson Medical School University of California, Irvine School of Medicine Emory University School of Medicine

ETC. The World Health Organization(WHO/WPRO)-WHO West-Pacific Division

41

Part. 2

Leaders in Society

Proud Alumni of Seoul National University College of Medicine The alumni of SNUCM have left deep footprints in our society as well as the history of mankind. Being the first ever medical institute in Korea, SNUCM is proud to have nurtured the very finest leaders in education, research and treatment.

the late

Lee Jong Wook•

23rd Graduating Class 1969

In 1983, Lee Jong Wook began working at the WHO as a director of leprosy elimination in the South-Pacific. He led the efforts of reducing the world’s polio

Shin Young Soo•

patients down to 1 in 10,000, and got the nickname ‘King of Vaccine'. He was

23rd Graduating Class 1969

appointed a Director-General of the WHO

Served as a Professor of Health Policy and

in 2003. He was called "Schweizer of Asia"

Management at SNUCM. He worked as a

due to his noble spirit, and was named "The

Served diverse positions of education

President of the Health Insurance Review

100 Most Influential People in the World"

and health politics, such as Professor of

and Assessment Service of Korea. He was

by Time magazine in 2004.

Preventive Medicine at SNUCM, Dean

elected as the head of the World Health

of SNUCM, President of Seoul National

Organization's Western Pacific Region

University, and President of Korea National

(WHO/WPRO), who is in charge of

University of Education. He was also deeply

health and welfare of approximately 1.8

Kwon Lee Hyuk• 1st Graduating Class 1948

Major Positions • Director of Center for Disease Prevention and Control, WHO/WPRO

involved in the government affairs as a

billion people, or about 30% of the world's

• Director of Vaccine Safety, WHO

Minister of Education, Health and Welfare,

population.

• 6th Director-General of WHO

• Director of Tuberculosis, WHO

and Environment.

Major Positions Major Positions

42

• Honorary President of Dong-A Socio Holdings

• 10th~12th Dean of SNUCM

• President of Korea Pharmaceutical Manufacturers Association

• 2nd President of Seoul National University Hospital

• Germany First Cross Merit awardee

• 15th President of Seoul National University

• Chairman of Sangju High School Foundation

• 26th Minister of Education

• Foundational President of the 16th Korean Youth Association

Leaders in Medicine

the late

Kim Chung Yong•

13th Graduating Class 1959

In the late 1960s, the major cause of chronic liver disease in Korea was hepatitis B virus infection. In 1973, he succeeded in isolating the hepatitis B virus antigen from

Lee Ho Wang•

the serum. Then, he developed the safest and most effective vaccine against hepatitis

8th Graduating Class 1954

B, cirrhosis and primary hepatocellular

Leading medical scientist and microbiologist

carcinoma associated with hepatitis B virus.

in Korea. He discovered the 'Hantan Virus'

His broad contribution to public health by

and 'Seoul Virus', which are epidemic

significant reduction of hepatitis prevalence

hemorrhagic fever pathogens, for the first

in Korea, gave him a nickname 'Liver

In 1980, he volunteered at the National

time in the world and contributed to human

Doctor'.

Sorokdo Hospital, and started to take care of

Kim In Kwon• 29th Graduating Class 1975

health welfare by developing preventive

the leprosy patients. In 1983, he gave

vaccine and diagnosis method.

up all his profits and started to work for

He is also the first Korean member of the

Major Positions

rehabilitation and human rights for the

American Academy of Arts and Science,

• President of Korean Society of Internal Medicine

underprivileged at Yeosu Aeyang Hospital.

• President of Korea Research Foundation

Since the mid-1990s, he continued his

and the honorary member of the Japan Academy.

• Korea Science Award • National Medal of the Mugunghwa

service for the neglected class of people whoc is suffering from arthritis.

Major Positions • US Best Citizen's Merit • Awardee of Inchon Prize, Science Prize, Ho-Am Prize

Major Positions

• Prince Mahidal Award of Thailand

• Awarded the 2nd Jang Kiryu Award

• Changjojang Medal for Excellence in Science and Technology

• National Medal of the Mugunghwa

• Induction to Korean Science and Technology Hall of Fame

• 4th Sungchun Award

• Korean Science and Technology Man of Merit

• Honorary Director of Yeosu Aeyang Hospital

43

Part. 2

Training Hospitals

Six centers for efficient research and training 01

h tt p : / / w w w. s n u h . o r g

02

h tt p : / / w w w. s n u b h . o r g

03

h tt p : / / w w w. b r m h . o r g

04

h tt p : / / w w w. s n u h . o r g / ch i l d /

05

h tt p : / / c a n c e r. s n u h . o r g

06

h tt p : / / h e a l t h c a r e . s n u h . o r g

44

01

02

03

Seoul National University Hospital

SNU Bundang Hospital

As Korea’s leading hospital,

SNU Bundang Hospital is equipped with

SNUH is endeavoring to raise Korean

cutting-edge digital facilities and systems,

Seoul Metropolitan Government-SNU Boramae Medical Center

medicine to the global standard.

providing preeminent medical services

SMG-SNU Boramae Medical Center

for patients.

provides reliable, high-quality medical

•Ranked first in the Korea Brand Power Index for 18 consecutive years •Ranked first in the National Brand Competitiveness Index

•Korea’s first EMR (Electronic Medical Record) Hospital •First to be awarded the “Beautiful Hospital” prize

•The first university hospital to earn

service to all Seoul citizens.

•2018 Best medical institution for stroke treatment •The first metropolitan/provincial public hospital to be certified by the Ministry of Health and Welfare

Healthcare Organization accreditation from the Ministry of Health and Welfare

04

05

06

SNU Children’s Hospital

SNU Cancer Hospital

SNU Children’s Hospital opened up

With state-of-the-art medical

SNU Hospital Healthcare System Gangnam Center

new frontiers for treatment and cures for

facilities and relentless research,

With its outstanding medical staffs and

children’s diseases.

SNU Cancer Hospital is

superior facilities, SNU Hospital Healthcare

moving closer to curing cancer.

System Gangnam Center is providing

•Opened in 1985, Korea’s first hospital specializing in children

•Opened in 2011 •28 Professional Centers

unrivalled medical service.

•Ranked first in the Korea Brand Power(Healthcare System) Index for 5 consecutive years •2010 Grand Prize of Medical Korea Awards

45

Pro d u c e d by STO RYM A KER CO M PA N Y

From the finest

www. s to r y ma ke r- c o mp a ny. c o m

Medical University in Korea To leading international medical research center

SE O U L N AT IO N A L U N IV E R SIT Y C O LLE G E O F M E D IC IN E

SNUCM 03080 103, Daehak-ro, Jongno-gu, Seoul, Republic of Korea TEL. 02–740–8114

FAX. 02–740–8190 http://medicine.snu.ac.kr