Lu-177-PSMA Therapy

This handout provides informa on for lute um-177 prostate specific membrane an gen therapy

and destroys them. Thus, it delivers the radioac ve material directly to the areas where the cancer

4-6 cycles depending on clinical response to treatment. The dose is injected over 2-5 minutes. You may also receive prescrip ons for medica ons to help you avoid nausea or vomi ng.

Your referring doctor recommended this treatment to manage your metasta c prostate cancer because you meet the following qualifica ons: Tumor is inoperable (cannot be treated with surgery) You must have adequate bone marrow and kidney func on, and general mobility (can handle self-care and not immobile or using a wheelchair) to receive this treatment If treatment becomes toxic to your kidney or bone marrow, we will reduce your treatment dose or delay your treatment If these toxici es persist, it may be necessary to discon nue treatment No fy your therapy team if you have urinary incon nence Is there any special prepara on for this treatment?

You will be seen in the nuclear medicine clinic with prescrip on to assess suitability for therapy.

Blood tests will be done approximately 2 weeks before therapy, such as kidney func on and blood counts, before star ng treatment and before each subsequent therapy.

(200 millicurie) every 6 weeks for up to a total of 6 doses Group 1 had a 4-month longer overall survival or Group 1 lived 5.3 months longer without cancer growing or spreading (progression-free survival or

Note: These side effects occurred in approximately 20 out of 100 people The most common laboratory results that worsened hemoglobin, leukocytes, platelets, calcium, and sodium.

Note: These abnormal labs occurred in approximately 30 out of 100 people.

The major poten al severe side effects are renal toxicity (decrease in kidney func on) and myelosuppression (decrease in bone marrow func on).

Myelosuppression important to have your oncologist con nue to monitor you closely during your therapy. We will order

results.

Renal toxicity

Do I have to follow specific instruc ons to manage radia on exposure to family, friends or the general public?

As Lu-177 is radioac ve, there are certain precau ons to limit the exposure of the people around you.

Although the health risks to your family members and the general public are low; however, you must Night- me restric ons: No. of Days Sleep in a separate bed (separated at least 3 feet) 2 to 3 Sleep in a separate bedroom from infants or children.

7 Sleep in a separate bedroom from pregnant partners.

15 Day- me restric ons: You may return to work a er 2 to 3 Avoid close contact (less than 3 feet) with children and pregnant women.

7 Avoid extended me in public places.

2 to 3 Do not share items that come into contact with the mouth (i.e.: toothbrushes, ea ng 2 to 3 utensils) Use separate or disposable ea ng utensils.

2 to 3 Use a separate bathroom, if possible, and keep the toilet clean. Flush 2-3 mes a er 2 to 3 each use.

Use separate towels and washcloths.

2 to 3

of radionuclide within the body. This may or may not be required a er each scan, based on clinical needs.

References:

Photo credits: Sunway Cancer Centre