Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
• Cell membranes • ATP prod
Autophagosome
DNA
• Plasma membrane • Lysosome
No
Yes
Yes
Yes
No
Yes
Yes
Yes
• Yes • Neutrophils
Minimal
No
No
• Cell groups • Cell swelling • Picnosis
• Single cells • Lysis
• Single cells • Single cells • Cell shrinkage • Cell-‐in-‐cell • Picnosis
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
h2p://www.interpathology.org
Triglyceride – (fat)
O R-‐C-‐O-‐CH + lipase + Ca++ = (3) RCOO-‐Ca++ (soap) O R-‐C-‐O-‐CH2 O
Irreversible Cell Injury
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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Principles of Pathology
Irreversible Cell Injury
h2p://www.interpathology.org
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