Neuroscience Research Institute 2024 Impact Report

Neuroscience Research Institute 2024 Impact Report

Neuroscience Research Institute: Advancing the treatment of neurological disease and injury through innovative research and educational initiatives Mission: • To create a world-class infrastructure and collaborative community that

facilitates interdisciplinary research of neurological disease and injury

• To build bridges between innovative translational neuroscience research

and clinical implementation

• To foster educational and professional development opportunities for

junior investigators in the field

Director Ben Segal, MD; Associate Director Erica Bell, PhD

Leadership and organizational structure LEADERSHIP

LEADERSHIP COUNCIL

Benjamin Segal, MD Chair, Neurology Director, Neuroscience Research Institute

Benjamin Segal, MD Chair, Neurology Director, Neuroscience Research Institute

Erica Bell, PhD Associate Professor, Neurology Associate Director, Neuroscience Research Institute

Erica Bell, PhD Associate Professor, Neurology Associate Director, Neuroscience Research Institute Russ Lonser, MD Chair, Neurosurgery Luan Phan, MD Chair, Psychiatry

Phil Popovich, PhD Chair, Neuroscience John Sheridan, PhD Director, IBMR Elaine Mardis, PhD Co-Director, Nationwide Children’s Hospital – Institute of Genomic Medicine Anne Connolly, MD Chief of Neurology, Nationwide Children’s Hospital Sayoko Moroi, MD, PhD Chair, Ophthalmology and Visual Sciences

COMMITTEE STRUCTURE Leadership Council

Translational Research and Cross-Collaborations Committee

Biorepository, Brain Bank, and Integrated Database Committee

Education and Mentorship Committee

2024 IMPACT REPORT | 1

Neuroscience at Ohio State is growing Affiliated research funding increased by about 35% year over year.

NRI-Affiliated Neuroscience Research Funding (in $M) 110.8 82.1 58.6 31.1

36.6

2020

45.9

2021

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2022

2023

2024

Seed grants $375,000 in seed grants have been awarded since 2021

15 Grants Awarded • 8 Junior Faculty Awardees • 7 Postdoctoral Scholar/Research Scientist Awardees

7 Departments Represented • Cancer Biology and Genetics

• Neurosurgery

• Institute of Genomic Medicine

• Pediatric Neurology

(Nationwide Children’s Hospital) • Neurology • Neuroscience

(Nationwide Children’s Hospital) • Psychiatry (Institute of Behavioral

Medicine and Research)

Two trainee winners have secured roles with the NIH and as faculty.

Additional funding has stemmed from NRI seed grants including a Department of Defense grant and two NIH Research Career Development Awards, collectively amounting to more than $2 million in extramural funding.

2024 IMPACT REPORT | 3

Brain Bank and Biorepository by the numbers Patient Enrollment Over Time 1096

240

102

Jun ’22

604

456

Jan ’23

Jun ’23

801

Jan ’24

Oct ’24

Lifetime Patient Enrollment by Division 317 Neuroimmunology 249 Neurocognitive 211 Parkinson’s Disease and Movement Disorders 158 Lumbar Puncture Clinic 116 Neuromuscular 45 Others

Total Specimen in the Biorepository Plasma CSF Supernatant PBMCs Serum

3921 7610

3776 1181 609

DNA CSF Cell Pellet

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9106

Expanding resources to support Ohio State’s growing neuroscience community

Brain Bank Top Dx (127 total) Alzheimer’s Other Dx Lewy Body Dementia Frontotemporal lobar degeneration (FTLD)

73

11 18 25

Top Diagnoses 237 Multiple Sclerosis 207 Parkinson’s Disease 92 Alzheimer’s Disease

Number of Specimen Distributed Since 2021 Whole CSF Skin Biopsies Fibroblasts

24 13 6 4 100

Brain Slices . . . . . . . . . 20 CSF . . . . . . . . . . . . . . . . 54 Fresh Blood . . . . . . . . . . 2

Whole Blood

Fresh CSF. . . . . . . . . . . . 2

Muscle Needle Biopsy

Plasma . . . . . . . . . . . . 324 Serum . . . . . . . . . . . . . . 20

2024 IMPACT REPORT | 5

Providing neuroscience education opportunities Educational Symposiums Neurogenetics Symposium – Sept. 2021

Health Services Research – May 2024

Neuroimaging Symposium – Oct. 2022

Neurodegeneration – coming in 2025

Neuroimmunology Symposium – June 2023

Translational Neuroscience Research Short Course

70

This rigorous, enrollment capped, multidisciplinary neuroscience translational research training provides trainees and faculty the skills needed to advance their diagnostic capabilities and effective management of Participants neurological disorders.

“

10

Departments Represented

WHAT I ENJOYED ABOUT THE SHORT COURSE…

The step by step content that really walked you through the process of getting a translational research project started.”

2024 NRI Annual Retreat

Held on November 15, the NRI Annual Retreat was attended by students, faculty, researchers and clinicians from across Ohio State and Nationwide Children’s Hospital

330+ Registrants

“

125 Abstracts Submitted

108

Poster Presentations

21

Departments and Nationwide Children’s Hospital Departments Represented

WHAT I ENJOYED ABOUT THE RETREAT…

The variety of presentations—I love how each presentation is so nuanced in its subsection within the larger field of neuroscience.”

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Advanced interdisciplinary and translational research collaboration tools Unique, innovative resources enhance collaboration across the institution Rapid Sequencing Pipeline The rapid sequencing pipeline allows NRI staff to efficiently process fresh blood and cerebrospinal fluid samples for single-cell RNA sequencing (scRNA-seq) using the 10x Genomics platform. This includes TCR and BCR sequencing, providing valuable insights for neuroimmunological research.

Currently, the pipeline is supporting a funded grant focused on immunophenotyping individuals with Guillain-Barré Syndrome, as well as an investigator-initiated trial (IIT) targeting rare neuroimmune disorders.

Buffered human peripheral blood

Plasma PBMCs Ficoll

Ficoll

Erythrocytes (RBCs)

Collaboration Tool The NRI web-based collaboration tool connects researcher collaborators focused on translational neuroscience research projects. It also supports experimental design of translational projects.

Learn more about NRI tools and resources

2024 IMPACT REPORT | 7

Ongoing projects and collaborations Projects • Markers of Biological Aging in Multiple Sclerosis (PI: Zhang) • Impact of central nervous system injury on form and function of the

neuromuscular junction (PIs: Quatman and Balch)

• Understanding the genetic causes of Parkinson’s disease (PI: Park) • Validation of a cell-free messenger-RNA based diagnostic biomarker for

Alzheimer’s disease (PIs: Bell, Scharre, Harari)

• Skin fibroblast isolation for the derivation of induced-pluripotent stem cells for

tissue culture models of Neurological disease (PI: Kolb)

Collaborations • Superfluid Dx

superfluiddx.com

• Global Parkinson’s Genetics Program (GP2)

gp2.org/

• State of Ohio Action for Resiliency (SOAR) biospecimen storage

medicine.osu.edu/departments/psychiatry-and-behavioral-health/ research-and-clinical-trials/soar-study

NRI-BBB samples have been cited in the following journals: • The FASEB Journal

faseb.onlinelibrary.wiley.com/journal/15306860

• Acta Neuropathologica

link.springer.com/journal/401

• Nature Neuroscience

nature.com/neuro/

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Last Look Photos from 2024 NRI Annual Retreat

2024 IMPACT REPORT | 7

Neuroscience Research Institute go.osu.edu/NRI