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HELP FOR FIP® FIP TREATMENT SUPPORT HANDBOOK FIP CURE AWARENESS · SUPPORT · EDUCATION

by Debra Roberts

Table of Contents 3

About Help for FIP®

What is GS441524?

FIP Diagnostic Checklist

Veterinary Needs List

Using the Help for FIP® Treatment Tracking Web App

Is FIP Contagious?

FIP Treatment Protocol

FIP Treatment Process

FIP Treatment Timeline

Normal and Abnormal Expectations

Injection Tutorial and Supplies

GS-441524 Options and Oral Formulations

Supportive Care

Interactions, Other Treatments, and Feeding for FIP

Understanding Your Cat’s Bloodwork

Drug-Resistance, Relapses, and Entering Observation

35 Dr. Pedersen’s Summary 41 Other Frequently Asked Questions 44

Help for FIP® Articles, Tools, Copyright, and References

The Help for FIP® Mission

During the treatment journey, FIP cat owners and their vets can navigate the fear and uncertainty of FIP and attain a successful treatment and cure for their cats. This book is a guide that compiles and summarizes everything you need to know and understand about FIP research and treatment options. You, the owner, treat your cat and make every decision with the Help for FIP® experienced team, which helps you find safe, tested treatments and assists you in avoiding the many internet scams and untested products. FIP is time-sensitive, and delays affect the cat's response time to the treatment. We work together quickly to ensure your cat has the best chance of survival. Our highly efficient team has a free treatment-tracking web application at Help for FIP® (https://helpforfip.com). We also have public (education) and private (treatment-based) Facebook communities where you can share your success and ask questions of other FIP cat owners and experienced mentors. Please collaborate with your veterinarian for supportive care to ensure the most successful treatment. Never take on the treatment process alone. We can also help you find a supportive vet for FIP treatment in your area. Euthanization should be an absolute last resort. Treatment with GS-441524 can work in even the most critical conditions. We emphasize that owners work with their veterinarian whenever possible and select one knowledgeable about FIP and the use of GS-441524. Your veterinarians' most important role is to help ensure that the diagnosis of FIP is accurate and to identify any other complicating health problems. Some veterinarians are now prescribing the newer compounded GS4415245 formulations to their clients. Advisors are online Monday through Saturday EST, 9 am to 6 pm, to answer your questions and after hours for new cases. We appreciate your patience as we respond to many messages daily. Our regular jobs and families keep us busy, but your cat is our priority. We know firsthand what it means to save the lives of our precious cats and the frustration of waiting, finding the proper help, or relying on outdated and inaccurate information on the internet. For fast help with a FIP-diagnosed cat, please visit https://www.helpforfip.com. You can also message us using WhatsApp at 614-622-2340 or helpforfip@gmail.com. Your data and privacy is always protected and secure. To purchase a hardcopy of this book, please visit THIS SITE. No part of this book may be downloaded or printed without the author’s consent. Page 3

Using the Help for FIP® Treatment Tracking Web App Help for FIP® has a free web-based application to help track your cat's dosing.

Cat's Name

Once you submit your cat's "health and status intake," advisors will "Set the Treatment" by entering your chosen GS brand and the dose specific to your cat's type of FIP (Wet, Neuro, Ocular, Pleural, Dry, or combo). The beginning dose will be calculated using your cat's starting weight. It never decreases and only increases as your cat gains weight. . Each Monday, you'll weigh your cat and enter the updated weight in pounds/ounces or kilograms (preferred). The web app automatically converts the weight to kilograms for proper dosing. Your dose may or may not change depending on whether the cat gained enough to "tip the scale" to the next level at every .25kg. Dosing never goes backward, even if your cat loses weight.

www.helpforfip.com Page 10

Is FIP Contagious? Is FIP Contagious in Multi-Cat Environments? The short answer is "No." The long answer is... While contact transmission wasn't observed in experimental settings, researchers know that FIPV exists in the feces of some cats with FIP. Horizontal transmission is theoretically possible and may explain why cats in the same environment develop FIP. Dr. Pedersen doesn't believe exposing a cured FIP cat to a coronavirus-positive cat will cause a relapse in the cured FIP cat, but that, too, is theoretically possible. In summary, separating a FIP cat from its housemates is more stressful than allowing them to live as they're accustomed to, with cat-to-cat transmission of FIPV rare. 95% of cats have been or will be exposed to (and test positive for) the feline coronavirus (FCoV). A small percentage with FCoV will mutate and develop FIP. FCoV is transmitted through the fecal-oral route and is common for cats to become exposed in multi-cat households, shelters, feral colonies, or catteries. Most cats that contract FCoV won't develop FIP. The virus must undergo a mutation within the cat to cause FIP. The virus lives in the digestive tract and is shed in the feces. Cats can shed the virus continuously or intermittently for four to six months and even up to one year or more continuously or intermittently. Recurrent infections are also common. FCoV is spread through litter and carried on bodies and clothing. Virus-contaminated material is easily transferred to the paws and fur of susceptible cats and ingested during grooming. Younger cats are at a greater risk of developing FIP. The most common mode of transmission of FCoV is believed to occur when infected queens pass the virus to their kittens at five to eight weeks of age. Cats in shelters and catteries are more susceptible to the development of FIP. The same applies to purebred, male, and geriatric cats for unclear reasons. Stress depresses immunity and increases the likelihood of a FIPV mutation. Stressors include overcrowding, weaning, spaying/neutering, infections, a new household, new cats coming into a home, shipping cats, and the stress of pregnancy and lactation. Good hygiene practices, staunch litterbox maintenance, minimizing household stress, and managing existing infections are essential to reducing FCoV transmission and potential FIP mutation. Avoid stress and overcrowding. The coronavirus is easily killed with bleach and other disinfectants. If you've lost a cat to FIP, remove cat-related items that can't be washed or disinfected, such as scratching posts or soft toys. Clean and disinfect everything in the environment. Time will take care of the rest because viruses of this type are not long-lived in the environment. A few months are recommended, which is standard for most infectious diseases. Page 11

A Abdominal Effusion 24 Adverse Interactions and Reactions 25 A/G Albumin to Globulin Ratio 7 Alternatives to GS441524 39-40 Anemia 6 Antibiotics 25 Antibody Test 13 Appetite Stimulant 9 Assisted Feeding 24

B B12 9 BID (twice per day) Dosing 12, 24 Biopsy 7 Blood Draws 12, 13 Blood Transfusion 9, 24 Blood Values 7, 28-31 Blood/Lab Tracking Log 13, 51 Body Score 44-46 Body Temperature 14 Breeders 42, 49-50 Buffering GS441524 17

C Calm and Cozy Cat Wrap 22 Catteries 42, 49-50 Causes of FIP 5 Cerenia 9 Chest Fluid Draining 24 Chinese GS441524 4 Contagiousness 11 Copyright 52 Cure Determination 37 Cure Rate 12 Cytology 7

D Dehydration 15

Deworming 26 Diagnostics for FIP 5-8 Diarrhea Treatment 15 Diatomaceous Earth 47-48 Diluting GS441524 17 Dosing Calculations 10, 36, 52 Dosing Twice Daily (BID) 12 Dr. Niels Pedersen 3, 4, 35 Drug Contraindications 25 Drug Interactions 25 Drug Resistance 32 Drug Trials 13 Dry FIP 13

E Effusion Draining 24 EIDD 2801 (Molnupiravir) 39-40 Expectations 15, 35

F Facebook Group 3, 12 Facebook Page 3, 12-13 FAQ 41-42 FCOV Mutation to FIPV 7 Feeding a FIP Cat 27 Feeding Tube 23 Feeding a FIP Cat 24 Feline Coronavirus (FCOV) 7, 41 Fever 23 Flea Treatment 26 Frequently Asked Questions 41

G GC376 32, 40 Genetics and FIP 49-50 Gilead Sciences 4 GS441524 4, 20 GS441524 Storage 19 Page 56

Help For FIP 3 Hydration 23 Hypothermia 23

Observation 34, 36 Ocular FIP 13, 16, Ongoing Research 32-42 Oral Formulations 21

I Injection Process 17-19 Injection Supplies 17 Injections 17 Instagram 3

Jaundice 16

Parasites 25-26 PCR Test 5, 7 Pedersen, Niels 35-40 Pills and Tablets 21 Pleural Fluid 24 Prednisolone 9, 15

Lab Values 7, 28-31 Lab Work 13 Legal Treatment 4 Lesions and Sores 15-16 L-lysine 25 Luna First GS441524 Survivor 3 Luna's FIP Legacy 3

References and Works Cited 53 Refrigerate 19 Relapses 33, 38 Research 32-42 Resistance 39 Respirations 15 Rivalta Test 8 RT PCR FIPV Biotype 7, 51

M Measuring the Abdomen 24 Mirataz 9 Missed Injections 19 Molnupiravir (EIDD 2801) 32

N Nausea and Vomiting 9 Needles 17 Neurological FIP 13 Neuter/Spay 9, 42 Normal Treatment Expectations 15 Nucleoside Analog 4

S Scammers 43 Side Effects 39 Sock FIP Website 12 Sores and Lesions 15-16 Spay/Neuter 9, 42 Subcutaneous Fluids 9 Supportive Care 23 Syringe Feeding 24 Syringes 17

Page 57

T Temperature 23 Tests for FIP 5, 12 Tick Treatment 26 Transmission of FIP 11 Treatment Length 12-14, 41 Treatment Process 13 Treatment Protocol 12 Treatment Response 12-13, 15 Treatment Ending/Stopping 13, 41 Treatment Timeline 14 Treatment Tracking 10 Twice per day (BID) Dosing 12, 24

U Upper Respiratory Infections 15

V Vaccinations 25 Veterinarians and GS441524 4, 9 Veterinary Needs 9 Videos 17-19 Vitamin B12 9

W Website, Help for FIP 3 Website, Luna's FIP Legacy 3 Weighing Your Cat 13 Wet/Effusive FIP 13, 16, 24

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HELP FOR FIP® FIP TREATMENT SUPPORT

FIP CURE AWARENESS · SUPPORT · EDUCATION If a cat or kitten has been diagnosed with deadly FIP, we can help. Our team and very supportive community follow the advice and protocols of UC Davis’s researcher and professor emeritus, Dr. Niels Pedersen. The Help for FIP® team is highly experienced with all forms of FIP, including the critical supportive care factors that accompany FIP, and has helped over 3000 cats navigate a FIP diagnosis, including those in the most critical conditions. The Help for FIP® advisors are not veterinarians and always encourage owners to work with their vets during treatment. Debra Roberts, the group founder, participated in the 2017 UC Davis FIP drug trial with researcher and professor emeritus Dr. Niels Pedersen, where her cat, Luna, became the first to be cured with GS441524. By advocating and sharing current research, discouraging unnecessary euthanasia, and supporting the treatment process, Help for FIP® has guided thousands of owners through the 84-day treatment process. Please note: Help for FIP® is NOT affiliated with any other FIP group or organization. For immediate assistance: Email: helpforfip@gmail.com Website: www.helpforfip.com Phone: 614.622.2340 Facebook: www.facebook.com/groups/fipeducation