AE Rates Increase as CKD Progresses

Researchers analyzed data from NDD-CKD and prevalent and incident dialysis patients

THE PREVALENCE OF comorbidities and adverse events (AEs) increase with chronic kidney disease (CKD) stage, especially once dialysis is initiated, a new study finds.

Using the 2004-2017 UK Clinical Practice Research Datalink, Dustin J. Little, MD, of AstraZeneca in Gaithersburg, Maryland, and colleagues identified 310,953 patients with stage 3-5D CKD based on estimated glomerular filtration rate (eGFR).

Patients with nondialysis-dependent CKD (NDD-CKD), prevalent dialysis patients, and incident dialysis patients had high baseline rates of hypertension (32.1%, 60.4%, and 61.5%, respectively) and diabetes (13.1%, 40.1%, and 41.3%, respectively), investigators reported in BMC Nephrology Comorbidities were more common, median hemoglobin values were lower, and C-reactive protein values were higher in the dialysis than non-dialysis groups. As eGFR