Longitudinal section of an axon showing a current flow.
a) an action potential; b) record of microelectrode in neuron.
External transducer Implantable transducer • SQUID magnetometer • Renview bight • induction sensor • amperometric biosensor
DrEng Rostyslav Sklyar, Verchratskogo 15-1, Lviv 79010 Ukraine
Superconducting Organic and CNT FETs Based Biosensor/Transducer.
in vivo
VGS =
Fi 1 A SFETb
i
d
gDS
× JJ
di
(
i
- +
Rgate
receiving unit
VGS
°
Gate
visual and m un
lb h i
)
Cryostat following external units
(Bio)Telemetry
Cin/2
unit
SuFET Draine transmitting Cin/2
Source
B
QG hωT (QG ) + 1 − 1 − (ibio / I 0 ) 2 2e C
d bi
gate
Vg Voutbio
channel‘s
myelin
axons
SFET SuFET
ionic currents
nerve NI impulse
A
A- implantation of the whole SuFET variant; B- tapping of BS on the external SuFET by implantable wire contacts.
SuFETTr as the inclusion of a SuFET device into the nerve fibre.
2
Shield
H
C0
i
Source
× JJ
g DS
C in /2
- +
C in /2
Cryostat
Draine
SuFET
R gate
and
gdn=I0/V C
V GS
°
Gate
Nerve fibre, synapses of neurons, DNA spiral
JJ- indicates Josephson junction.
…
bi o
(EN) =4kTSuFET γnoise/gdn
L
~
E0
R
PC
Equivalent circuit of a SuFETTr of vortical magnetic field H around a biochemical medium.
Superconducting Organic and CNT FETs Based Biosensor/Transducer- Design of the Circuit
bio
A
B
A- the schematic structure of the fabricated OFET; B- transfer characteristics of the single crystal FET device at a source-drain voltage Vd of -30 V.
OFET of organic single crystals with bottom-contact configuration.
i
U out
t
i bio
A
V o ut
B
bio
Vsup=const
i
0
200
-
Q, nS 400 -
t
I
Vout
1
Vg, V
A 4 by 4 crossed NW-FET array
Operational pattern of a parallel SuFETTr.
An organic SuFET device Schematic of the electrolyte and its electrodes. gate measurement.
Superconducting Organic and CNT FETs Based Biosensor/Transducer.
implantab.
decoding
the BSs of
nucleoted
recognition
propag. of
BS along
DNA’s
spirals
DNA
molec.
centr. of m.
molec.
DNA’s sp.
namic on
length dy-
space and
type of
Molecules and chem. BSs→ con-
+i bio(fN)
sens. imp.
di bio/dx
di bio/dt,
external
outputs
teds → 4
4 nucleo-
molec.
and chem.
ΣBSs=Σbio
1 fibre
work or
Σi bio=1 net-
implantab.
PARALLEL
ΣBSs=1
i bio(f2)+…
ntrol or
i bio=1 co- i bio=i bio(f1)+
external
SERIAL
BSs→bio variation of
NI
MEDIUM
MODE
Table: Dependence of the received BS parameters on the mode of SuFETTr’s functioning.
Author contact information: DrEng. Rostyslav Sklyar Verchratskogo st. 15-1, Lviv 79010 Ukraine. Tel. +38 097 3365495 Fax:+38 0322 769613; sklyar@cb-igph.lviv.ua
1. Sklyar R., A SuFET Based Either Implantable or Non-Invasive (Bio)Transducer of Nerve Impulses", 13th International Symposium on Measurement and Control in Robotics ISMCR'03, Madrid, Spain (2003), pp. 121-126; 2. Sklyar R., Superconducting Organic and CNT FETs as a Biochemical Transducer, ISMCR 2004: 14th International Symposium on Measurement and Control in Robotics, 16-18 September 2004 - NASA Johnson Space Center, Houston, Texas, section 24 (the second), (13 pages); 3. Sklyar.R., A superconducting biosensor of the biosignals, Eurosensors XVIII, September 13-15, 2004, Roma; Italy, Digest Book (4 pages).
Superconducting Organic and CNT FETs Based Biosensor/Transducer.