Superconducting Organic and CNT FETsBased Biosensor/Transducer

Longitudinal section of an axon showing a current flow.

a) an action potential; b) record of microelectrode in neuron.

External transducer Implantable transducer • SQUID magnetometer • Renview bight • induction sensor • amperometric biosensor

DrEng Rostyslav Sklyar, Verchratskogo 15-1, Lviv 79010 Ukraine

Superconducting Organic and CNT FETs Based Biosensor/Transducer.

in vivo

VGS =

Fi 1 A SFETb

i

d

gDS

× JJ

di

(

i

- +

Rgate

receiving unit

VGS

°

Gate

visual and m un

lb h i

)

Cryostat following external units

(Bio)Telemetry

Cin/2

unit

SuFET Draine transmitting Cin/2

Source

B

QG hωT (QG ) + 1 − 1 − (ibio / I 0 ) 2 2e C

d bi

gate

Vg Voutbio

channel‘s

myelin

axons

SFET SuFET

ionic currents

nerve NI impulse

A

A- implantation of the whole SuFET variant; B- tapping of BS on the external SuFET by implantable wire contacts.

SuFETTr as the inclusion of a SuFET device into the nerve fibre.

2

Shield

H

C0

i

Source

× JJ

g DS

C in /2

- +

C in /2

Cryostat

Draine

SuFET

R gate

and

gdn=I0/V C

V GS

°

Gate

Nerve fibre, synapses of neurons, DNA spiral

JJ- indicates Josephson junction.

…

bi o

(EN) =4kTSuFET γnoise/gdn

L

~

E0

R

PC

Equivalent circuit of a SuFETTr of vortical magnetic field H around a biochemical medium.

Superconducting Organic and CNT FETs Based Biosensor/Transducer- Design of the Circuit

bio

A

B

A- the schematic structure of the fabricated OFET; B- transfer characteristics of the single crystal FET device at a source-drain voltage Vd of -30 V.

OFET of organic single crystals with bottom-contact configuration.

i

U out

t

i bio

A

V o ut

B

bio

Vsup=const

i

0

200

-

Q, nS 400 -

t

I

Vout

1

Vg, V

A 4 by 4 crossed NW-FET array

Operational pattern of a parallel SuFETTr.

An organic SuFET device Schematic of the electrolyte and its electrodes. gate measurement.

Superconducting Organic and CNT FETs Based Biosensor/Transducer.

implantab.

decoding

the BSs of

nucleoted

recognition

propag. of

BS along

DNA’s

spirals

DNA

molec.

centr. of m.

molec.

DNA’s sp.

namic on

length dy-

space and

type of

Molecules and chem. BSs→ con-

+i bio(fN)

sens. imp.

di bio/dx

di bio/dt,

external

outputs

teds → 4

4 nucleo-

molec.

and chem.

ΣBSs=Σbio

1 fibre

work or

Σi bio=1 net-

implantab.

PARALLEL

ΣBSs=1

i bio(f2)+…

ntrol or

i bio=1 co- i bio=i bio(f1)+

external

SERIAL

BSs→bio variation of

NI

MEDIUM

MODE

Table: Dependence of the received BS parameters on the mode of SuFETTr’s functioning.

Author contact information: DrEng. Rostyslav Sklyar Verchratskogo st. 15-1, Lviv 79010 Ukraine.

Tel. +38 097 3365495 Fax:+38 0322 769613; sklyar@cb-igph.lviv.ua

1. Sklyar R., A SuFET Based Either Implantable or Non-Invasive (Bio)Transducer of Nerve Impulses", 13th International Symposium on Measurement and Control in Robotics ISMCR'03, Madrid, Spain (2003), pp.

121-126; 2. Sklyar R., Superconducting Organic and CNT FETs as a Biochemical Transducer, ISMCR 2004: 14th International Symposium on Measurement and Control in Robotics, 16-18 September 2004 - NASA Johnson Space Center, Houston, Texas, section 24 (the second), (13 pages); 3. Sklyar.R., A superconducting biosensor of the biosignals, Eurosensors XVIII, September 13-15, 2004, Roma; Italy, Digest Book (4 pages).

Superconducting Organic and CNT FETs Based Biosensor/Transducer.