Explore the science behind creatine’s role in brain energy metabolism during sleep loss—how cerebral creatine and ATP buffering support working memory, decision-making, attention, and mood under fatigue. This PDF reviews clinical and preclinical evidence, proposed mechanisms (mitochondrial support, neurotransmitter balance, neuroprotection), practical dosing/timing considerations, safety, and emerging delivery technologies from Project Creatine to optimize cognitive recovery during sleep deprivation.