Timeline of Semaglutide development and approval

Timeline

of

Semaglutide

approval

development

and

-By Polypeptide.ltd

Authoritative source：PubChem More recently, Semaglutide powder has grown in popularity as an injectable weight-loss medication.

There has been a long history of research on semaglutide. The development history of semaglutide is marked by its progression from an innovative treatment for type 2 diabetes to an effective medication for weight management. Here’s a timeline of key events in the development and approval of semaglutide and its related products: 2008: Phase II clinical trial studying semaglutide begins.

Custom Synthesis Peptide Manufacturers

https://www.polypeptide.ltd/

2012: Researchers at Novo Nordisk develop semaglutide as a potential diabetes therapy.

2016-2017: Clinical trials evaluating semaglutide’s efficacy in blood sugar control and cardiovascular risk reduction are conducted.

October 2017: FDA Advisory Committee unanimously approves semaglutide for diabetes treatment.

December 2017: Semaglutide, branded as Ozempic, receives FDA approval for diabetes management in the United States.

January 2018: Ozempic is approved for use in Canada.

February 2018: Authorization is granted for Ozempic’s use in the European Union.

Japan approves Ozempic for medical use.

August 2019: Australia approves Ozempic for medical use.

Oral semaglutide (Rybelsus) receives FDA approval for diabetes treatment in the United States.

April 2020: Rybelsus gains approval for medical use in the European Union.

June 2021:

Custom Synthesis Peptide Manufacturers

https://www.polypeptide.ltd/

A higher-dose version of semaglutide, Wegovy, gains FDA approval for long-term weight management in adults.

November 2021: The CHMP of the European Medicines Agency recommends marketing authorization for Wegovy.

January 2022: Wegovy gains approval for medical use in the European Union.

January 2023: The label for Rybelsus is updated to reflect its use as a first-line treatment for adults with type 2 diabetes.

This timeline highlights the key milestones in semaglutide’s development, from its initial research and clinical trials to its various approvals for diabetes management, weight loss, and cardiovascular risk reduction, prove that semaglutide powder is a effective medicine for weight loss and type 2 diabetes treatment. Research into semaglutide’s mechanisms of action, safety, and efficacy continues, with ongoing studies investigating its effects on metabolic health and potential applications beyond diabetes and obesity. Peptide researchers who want to buy semaglutide powder to do the research will find that buying semaglutide powder online is a cost-effective choice.

Though many semaglutide powder for sale online, finding a reputable semaglutide peptide manufacturer will be a challenge.

How does semaglutide works?

Semaglutide operates through its role as a glucagon-like peptide-1 (GLP-1) receptor agonist, closely emulating the actions of the natural GLP-1 hormone released post-meal. By binding to GLP-1 receptors on pancreatic beta cells, semaglutide stimulates insulin secretion, aiding in glucose uptake and lowering blood sugar levels. Simultaneously, it suppresses glucagon release, curbing liver-generated glucose output. The medication also slows gastric emptying, fostering prolonged fullness and controlled nutrient absorption. This is reinforced by heightened feelings of satiety and reduced appetite facilitated by semaglutide’s interaction with GLP-1 receptors in the brain. These mechanisms collectively contribute to improved blood sugar control, reduced appetite and sustainable weight loss, making semaglutide a valuable medication for both diabetes management and long-term weight management.

Custom Synthesis Peptide Manufacturers

https://www.polypeptide.ltd/

Reference citations [1] Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group.”Once-Weekly Semaglutide in Adults with Overweight or Obesity.”N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10.PMID: 33567185 [2] Rubino DM, Greenway FL, Khalid U, O’Neil PM, Rosenstock J, Sørrig R, Wadden TA, Wizert A, Garvey WT; STEP 8 Investigators.”Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.”JAMA. 2022 Jan 11;327(2):138-150. doi: 10.1001/jama.2021.23619.PMID: 35015037 [3] Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K; SURPASS-2 Investigators.”Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.”N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25.PMID: 34170647 [4] Weghuber D, Barrett T, Barrientos-Pérez M, Gies I, Hesse D, Jeppesen OK, Kelly AS, Mastrandrea LD, Sørrig R, Arslanian S; STEP TEENS Investigators.”Once-Weekly Semaglutide in Adolescents with Obesity.”N Engl J Med. 2022 Dec 15;387(24):2245-2257. doi: 10.1056/NEJMoa2208601. Epub 2022 Nov 2.PMID: 36322838 [5] Smits MM, Van Raalte DH.”Safety of Semaglutide.”Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563. eCollection 2021.PMID: 34305810 [6] Rubino D, Abrahamsson N, Davies M, Hesse D, Greenway FL, Jensen C, Lingvay I, Mosenzon O, Rosenstock J, Rubio MA, Rudofsky G, Tadayon S, Wadden TA, Dicker D; STEP 4 Investigators.”Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial.”JAMA. 2021 Apr 13;325(14):1414-1425. doi: 10.1001/jama.2021.3224.PMID: 33755728 [7] O’Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, Carson CG, Jepsen CH, Kabisch M, Wilding JPH.”Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial.”Lancet. 2018 Aug 25;392(10148):637-649. doi:

Custom Synthesis Peptide Manufacturers

https://www.polypeptide.ltd/

10.1016/S0140-6736(18)31773-2. Epub 2018 Aug 16.PMID: 30122305 [8 ]Chao AM, Tronieri JS, Amaro A, Wadden TA.”Semaglutide for the treatment of obesity.”Trends Cardiovasc Med. 2023 Apr;33(3):159-166. doi: 10.1016/j.tcm.2021.12.008. Epub 2021 Dec 21.PMID: 34942372 [9] Singh G, Krauthamer M, Bjalme-Evans M.”Wegovy (semaglutide): a new weight loss drug for chronic weight management.”J Investig Med. 2022 Jan;70(1):5-13. doi: 10.1136/jim-2021-001952.

Epub 2021 Oct 27.PMID: 34706925 [10] Wadden TA, Bailey TS, Billings LK, Davies M, Frias JP, Koroleva A, Lingvay I, O’Neil PM, Rubino DM, Skovgaard D, Wallenstein SOR, Garvey WT; STEP 3 Investigators.”Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial.”JAMA. 2021 Apr 13;325(14):1403-1413. doi: 10.1001/jama.2021.1831.PMID: 33625476 [11] Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN.”Semaglutide as a promising antiobesity drug.”Obes Rev. 2019 Jun;20(6):805-815. doi: 10.1111/obr.12839. Epub 2019 Feb 15.PMID: 30768766 [12] Meier JJ.”Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation.”Front Endocrinol (Lausanne). 2021 Jun 25;12:645617. doi: 10.3389/fendo.2021.645617. eCollection 2021.PMID: 34248838 [13] Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, Jódar E, Kandler K, Rigas G, Wadden TA, Wharton S; STEP 5 Study Group.”Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.”Nat Med. 2022 Oct;28(10):2083-2091. doi: 10.1038/s41591-022-02026-4. Epub 2022 Oct 10.PMID: 36216945 [14] Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbøll T, Warren ML, Bain SC; PIONEER 6 Investigators.”Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.”N Engl J Med. 2019 Aug 29;381(9):841-851. doi: 10.1056/NEJMoa1901118. Epub 2019 Jun 11.PMID: 31185157 [15] Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, Lingvay I, McGowan BM, Oral TK, Rosenstock J, Wadden TA, Wharton S, Yokote K, Kushner RF; STEP 1 Study Group.”Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.”Diabetes Obes Metab. 2022 Aug;24(8):1553-1564. doi: 10.1111/dom.14725.

Custom Synthesis Peptide Manufacturers

https://www.polypeptide.ltd/

Epub 2022 May 19.PMID: 35441470

Custom Synthesis Peptide Manufacturers

https://www.polypeptide.ltd/