TadalafilProperties
ProductNameTadalafilpowder
-ByPhcoker
Chemical Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1 ′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
BrandNameCialis,Adcirca,Alyq,Entadfi,Tadliq
CASNumber171596-29-5
InChIKeyWOXKDUGGOYFFRN-IIBYNOLFSA-N
Molecular Formula
Molecular Weight
Monoisotopic Mass
C22H19N3O4
389.4
389.138g/mol
MeltingPoint298-300°C
Color
Solubility
Storage Temperature
Tadalafil Application
WhitetoOff-WhiteCyrstallineSolidPowder
SolubleinDMSO(78mg/mlat25°C),methanol,water(<1mg/mlat25°C), dichloromethane,andethanol(<1mg/mlat25°C)
Storeatroomtemperaturebetween59°Fand86°F(15°Cand30°C)Don’tstore thismedicationinmoistordampareas.
tablets,pills,capsules,functionaldrinks,candy,coffee
PeptideGMPManufacturers
www.phcoker.com PopularpeptideTadalafilpowderinPhcoker
TadalafilHistory丨TadalafilBackground
Tadalafilpowderistheactiveingredientoftadalafil-basedmedicine,itisaselective phosphodiesterase-5inhibitorthatisusedinthetreatmentoferectiledysfunction(ED),pulmonary arterialhypertension(PAH),andbenignprostatichypertrophy.Hereistimetableoftadalafil development:
August1991:TadalafilwasdiscoveredbyGlaxoWellcome(nowGlaxoSmithKline)undera partnershipbetweenGlaxoandICOStodevelopnewdrugs.
In1993:TheBothell,Washington,biotechnologycompanyICOSCorporationbeganstudying compoundIC351,aphosphodiesterasetype5(PDE5)enzymeinhibitor
In1994：ICOSreceivedapatentforcompoundIC351(structurallyunlikesildenafilandvardenafil), andPhase1clinicaltrialsbeganin1995In1997,thePhase2clinicalstudieswereinitiatedfor malesexperiencingED,thenprogressedtothePhase3trialsthatsupportedthedrug'sFDA approval.
In1998:tadalafilbefurtherdevelopandcommercializeasatreatmentforED.
May2002:CinicaltrialtestingdemonstratedthatTadalafilwaseffectiveforupto36hours
In2003:TadalafilbeapprovedbyFDA
October2011:TadalafilapprovedbyUSFDAtotreatthesignsandsymptomsofbenignprostatic hyperplasia
ByviewingthebackgroundintroductionofTadalafil,youcanhaveaclearerunderstandingofthe entiredevelopmenthistoryoftadalafilAsoneofthebestsellEDtreatmentdrugsinthemarket,
Tadalafilsoldunderdifferentbrandnameanddifferentformsincludeoralpill,capsule,tablet.Cialis andAdcircaaretwoofthepopularbrandname
Tadalafilpowderastheactiveingredientoftadalafil-baseddrugs,wecanhaveadeeper understandingoftadalafilpowderthroughtheserelatedproducts,includingitsbenefits,side effectsetcLet'scontinuetohavealook
WhatIsTadalafil丨TadalafilPowder?
Tadalafilisamedicineusedtotreaterectiledysfunction(ED,alsocalledimpotence)andproblems withurinationcausedbyanenlargedprostate(benignprostatichypertrophyorBPH)Itis sometimesknownbyitsgenericnametadalafil,andsometimesknownbyitstradename,Cialis Therearealsootherbrandsofthismedicineavailable,suchasAdcirca,Alyq,Entadfi,Tadliq.
Tadalafilpowderistheactiveingredientofthetadalafilbrandproduct.Itisawhitetooff-white powder,manufactureredbychemicalfactories,ChinaandIndiaarethetwomajorsuppliersof Tadalafilpowder.Tadalafilpowdersuppliedwithdifferentpuritystandard,thebestis99.99%pure rawpowderformTadalafilpowderpriceinIndiaistotallydifferentthanChinaResearchers seekingtadalafilpowderforresearchpurposeorindividualwhoreselltadalafilpowderfoundthat, althoughthetadalafilpowdermanufacturersclaimthepurityis>99%,butthetestingresultistotally different,someofthemevennoanyeffects.Soitischallengetofindoutthebestsupplierfromso manytadalafilpowdermanufacturers.
HowDoesTadalafilWork丨MechanismOfActionOfTadalafil
Tadalafilisapopularproductinthemarket,individualcanbuytadalafilwithprescriptionfrom pharmacyorthedoctorprescribesitforyouHowistadalafilwork?Whatisthemechanismof actionoftadalafil?Tadalafilmainlyactsinthreedirections,heretheyare:
Tadalafilforerectiledysfunction(ED):Ifyouhaveerectiledysfunctionalsocalledsexualimpotence, whensexuallyaroused,itoperatesbytransientlyboostingbloodcirculationtothepenis.However,
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withoutphysicalstimulationtothepenis,suchasduringsexualintercourse,tadalafilwillnotinduce anerection
Tadalafilforbenignprostatichyperplasia(BPH):TadalafilAidsinalleviatingsymptoms associatedwithanenlargedprostateglandbyrelaxingthemusclesinboththeprostateandbladder IndividualswithBPHtypicallyexperiencechallengeswithurination,includingdecreasedflowand hesitancyattheonsetofurination.
Tadalafilforpulmonaryhypertensiontreatment:Menandwemenwhoexperiencingsymptoms ofpulmonaryarterialhypertension,wherethesmallerbloodvesselsinthelungsbecomemore
resistanttobloodflow,findthattherightventricleoftheheartmustexertgreatereffortto adequatelypumpbloodthroughthelungsTadalafilactsonthePDE5enzymewithinthelungsto
relaxbloodvessels,therebyenhancingbloodsupplytothelungsandalleviatingtheheart's workload.
ItispreciselybecauseTadalafilworksthroughtheabove3waysandbringsgreatconvenienceto people'slivesthatmoreandmorepeoplearebuyingTadalafilfordifferentpurposesTadalafil relateddrugsoldunderdifferentbrandnamefordifferentpurpose,liketadalafil5mg,tadalafil 20mgtabletfororal,peoplecanchoosetobuytheformofTadalafilthatsuitsthemaccordingto theirneedsButtadalafilpriceisdifferentfromplacetoplace,besurebuyitfromthebesttadalafil suppliers!
WhatAreTheBenefitsYouCanGetFromTadalafil丨TadalafilBen efits
Oneofthemostwell-knownbenefitsoftadalafilisasatreatmentformaleerectiledysfunction(ED)
Whilethisisthecommonbenefitsoftadalafil,tadalafilhavesomeothergoodbenefitsformenand wemen,herearetheprimary8benefitsoftadalafilin2024:
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TadalafilforErectileDysfunction(ED):Tadalafilispopularsellforsexualfunctionproblem treatment,incombinationwithsexualstimulation,tadalafilworksbyincreasingbloodflowtothe penistohelpamangetandkeepanerectionThistypeofTadalafildrugisusuallyavailableonthe marketindifferentdosagestrengths,fromsmalldosage25mgtolargedosage20mg
Tadalafilforenlargedprostate:Researchshowthattadalafilhelpstotreatandprevent enlargementoftheprostate,althoughtadalafilisnotthefirstlinetreatmentforprostateconditions, butithelpstorelievesymptomsofBPH
Tadalafilforheartperformanceimprovement:Amongtheremarkablehealthadvantages associatedwithtadalafilisitscapacitytoenhanceheartfunctionResearchindicatesthatuse tadalafilcanalleviatesymptomsofpulmonaryarterialhypertensionandenhancephysicalendurance inindividualssufferingfromchronicheartfailure.Notably,astudyrevealedthatindividualswho took20mgdosesoftadalafilforsixmonthsexperiencedenhancedbloodcirculationandincreased oxygendeliverytotheirhearts.
Tadalafilforbloodpressurecontrol:Anotherbenefitsoftadalafiluseisithelpsreduceblood pressureStudiesshowthatalotofpatientshavereportedtadalafilcanreducesystolicblood pressureby4-5mmHgovera24-hourperiod
Tadalafilissafetouse:asaprescriptiondrug,tadalafilhasquitemildsideeffects.Researchdatas showthattakingdailydosageoftadalafil2.5mgor5mgmeanshavingaconstantworking concentratoninyourbody,insteadofthepeaksandtroughsyougetwithoccasionaldosing,this helptoreducestheirritatingsideeffectsoftadalafil
Tadalafilforlongevity:Studiesin2020foundanotherusefulbenefitsoftadalafilThestudy showedthatTadalafilhasapositiveeffectonvascularendothelialcellregenerationbyincreasing theamountofendothelialprogenitorcellsandCXCR4expressionwhichislinkedtothecGMP
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cellularmessengersystemresultinginimprovedrepairofvasculardamage.Soitmeantadalafilcan helptoimprovetherepairandrecoveryoftheliningofbloodvesselwallsthusimproving cardiovascularhealthandlongevity
Tadalafilforantidepressantuse:Oneofthemostexcitinghealthbenefitsoftadalafilisits potentialforfightdepression.Thereareresearchresultsindicatethattadalafiliseffectiveintreating depressioninmenbyboostingserotoninlevelsinthebrain,whichhelpsliftmoodandfightoff feelingsofsadnessanddespair.
Tadalafilforself-confidencebuilding:Erectiledysfunctionisaproblemfacedbymoreandmore men,andtheirself-confidenceisseverelyaffectedbythisproblemTadalafilisamedicationwhich comesundertheclassofselectivePDE5inhibitors,itworksquicklyandeffectivelytohelpmen withEDgetandmaintainanerection.Therebyhelpingmenincreasetheirself-confidenceand improvetheirhappinessinlife.
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Authorofthisarticle:
Dr.JeanZenggraduatedfromking’scollegelondonFacultyofLifeSciences&Medicine.
ScientificJournalpaperAuthor:
1MiaoTang
DepartmentofPharmacy,Women'sHospital,ZhejiangUniversitySchoolofMedicine,Hangzhou 310006,China
2TomohiroNishimura
FacultyofPharmacy,KeioUniversity,1-5-30Shibakoen,Minato-ku,Tokyo,105-8512,Japan
3.EkkehardGrünigMD
ThoraxklinikatHeidelbergUniversityHospitalandTranslationalLungResearchCenter,German CenterforLungResearch,Heidelberg,Germany
4JaneSunZhangMD
DepartmentofDermatology,UniversityofIllinoisatChicago,Chicago,Illinois
5DhruvanshiGol
DepartmentofPharmaceuticalQualityAssurance,B.K.ModyGovernmentPharmacyCollege,
Polytechniccampus,NearAjidam,Rajkot,360003,Gujarat,India