1.WhatisSemaglutide?
Semaglutide(Wegovy,Ozempic,Rybelsus)isamedicineusedforweightlossinspecificpatients, andtolowerbloodsugarlevelsandreducetheriskofmajorcardiovasculareventssuchasheart attackorstrokeintypetwodiabetespatients.SemaglutideisaGLP-1agonistandworksby increasinginsulinrelease,loweringtheamountofglucagonreleased,delayinggastricemptyingand reducingappetiteInadditiontoregulatingbloodsugarlevels,semaglutidehasbeenfoundto significantlyreducebodyweight,makingitavaluableoptionforweightlossinspecificpatients.
2.HowdoesSemagutidework?
SemaglutideworksasaGLP-1agonist,meaningitmimicstheeffectsofahormonecalled glucagon-likepeptide-1(GLP-1)inthebody.GLP-1isnaturallyreleasedbytheintestinesin responsetofoodintakeandplaysacrucialroleinregulatingbloodsugarlevelsandappetite
Whensemaglutideisinjected,itbindstoandactivatesGLP-1receptorsonvariouscellsinthebody, includingpancreaticcells.Thisactivationleadstoseveralbeneficialeffects.First,semaglutide increasesinsulinreleasefromthepancreas,whichhelpslowerbloodsugarlevelsbyfacilitatingthe uptakeofglucoseintocellsforenergyIncreasedinsulinalsohelpstoreducetheproductionof glucosebytheliver.
Second,semaglutidesuppressesthereleaseofglucagon,ahormonethatraisesbloodsugarlevels Byreducingglucagonlevels,semaglutidefurthercontributestotheoverallcontrolofbloodsugar.
Anothereffectofsemaglutideistheslowingdownofgastricemptying,whichmeansthatfoodstays inthestomachforalongertimebeforemovingintothesmallintestineThisdelayinstomach emptyinghelpstoregulatetheabsorptionofnutrientsandcancontributetofeelingsoffullnessand reducedappetite.
Combined,thesemechanismsofactionhelpregulatebloodsugarlevels,promoteinsulinrelease, lowerglucagonrelease,andreduceappetiteAsaresult,semaglutidecanbeeffectiveinmanaging type2diabetes,aidinginweightloss,andreducingtheriskofcardiovasculareventsinspecific
patientpopulations.
3.WhatarethebenefitsofusingSemaglutide?
Semaglutideoffersseveralbenefitswhenusedasprescribedforitsapprovedindications.The specificbenefitsmayvarydependingontheconditionbeingtreated.Herearetheprimarybenefits associatedwiththeuseofsemaglutide:
❶Improvedbloodsugarcontrol.Semaglutide,asaGLP-1receptoragonist,helpsregulateblood sugarlevelsinindividualswithtype2diabetesItstimulatesinsulinreleasefromthepancreas, whichleadstobetterglucoseutilizationbythebody'scells.Byreducingglucagonsecretionand slowingdowngastricemptying,semaglutidehelpslowerbloodsugarlevelsandmaintainbetter glycemiccontrol.
❷Weightloss.Semaglutidehasbeenfoundtopromoteweightlosswhenusedforweight managementinindividualswithobesityorexcessweight.Bysuppressingappetiteandinducinga feelingoffullness,itcanhelpreducecalorieintakeandcontributetosustainableweightlosswhen combinedwithareduced-caloriedietandexercise.
❸Cardiovascularriskreduction.Inindividualswithtype2diabetesandestablished cardiovasculardisease,semaglutide(specificallyOzempic)hasbeenshowntoreducetheriskof majorcardiovasculareventslikeheartattackorstrokeThisbenefitcanprovideadditional protectiontoindividualswithbothdiabetesandcardiovascularconditions.
❹Potentialbenefitsincognition.Semaglutidehasshownpotentialbenefitsinimprovingcognitive function,particularlyinindividualswithmildcognitiveimpairmentormilddementiacausedby Alzheimer'sdiseaseIthasbeenfoundtoprotectagainstamyloid-βplaques,whichareassociated withcognitivedeclineinAlzheimer'sdisease.Preclinicalstudiesandongoingclinicaltrialsare evaluatingsemaglutide'simpactoncognitivefunctionResultsfromthesetrialswillprovidemore informationaboutsemaglutide'seffectivenessinimprovingcognitiveabilitiesinAlzheimer's disease
4.SideeffectsofSemaglutide
Sideeffectsfromsemaglutideinjectionmightoccur.Ifanyofthesesymptomsaresevereordonot goaway,letyourdoctorknowrightonce:
•vomiting
•nausea
•diarrhea
•abdominalpain
•constipation
•heartburn
•burping
Somesideeffectscanbeserious.Callyourdoctorrightawayifyouencounteranyofthese symptoms,orseekemergencycare:
•ongoingpainthatbeginsintheupperleftormiddleofthestomachbutmayspreadtotheback, withorwithoutvomiting
•rash;itching;swellingoftheeyes,face,mouth,tongue,orthroat;ordifficultybreathingor swallowing
•decreasedurination;orswellingoflegs,ankles,orfeet
•visionchanges
•faintingordizziness
•paininupperstomach;yellowingofskinoreyes;fever;orclay-coloredstools(inthosereceiving semaglutide[Wegovy]formanagementofweightloss)
•apoundingheart
OthernegativeeffectsfromsemaglutideinjectionarepossibleIfyouhaveanystrangeissueswhile takingthisdrug,callyourdoctorrightaway.
5.SemaglutidedosageInformation
(1)ForType2DiabetesMellitus
❶Ozempic(semaglutideinjection):
•InitialDose:0.25mgsubcutaneouslyonceweeklyfor4weeks.
•MaintenanceDose:Aftertheinitial4weeks,increasethedoseto05mgsubcutaneouslyonce weekly.
•FurtherDoseAdjustment:Ifglycemiccontrolisnotachievedafteratleast4weeksonthe05mg dose,thedosecanbeincreasedto1mgonceweekly
•MaximumDose:Ifneeded,thedosecanbefurtherincreasedto2mgonceweekly,butitshould notexceed2mgperweek
❷Rybelsus(oralsemaglutidetablets):
•InitialDose:3mgorallyoncedailyfor30days(intendedfortreatmentinitiation,notforglycemic control).
•MaintenanceDose:After30daysonthe3mgdose,increasethedoseto7mgorallyoncedaily
•FurtherDoseAdjustment:Ifadditionalglycemiccontrolisneeded,thedosecanbeincreasedto14 mgorallyoncedaily
•Note:Takingtwo7mgtabletstoachievethe14mgdoseisnotrecommended.
❸SwitchingbetweenOzempicandRybelsus:
•SwitchingfromRybelsustoOzempic:Startwith0.5mgsubcutaneouslyonceweeklyontheday afterthelastRybelsusdose
•SwitchingfromOzempictoRybelsus:Startwith7mgor14mgorallyoncedaily,upto7days afterthelastOzempicinjection.Thereisnoequivalentoraldoseforthe1mgOzempicdose.
(2)ForWeightManagement
❶Wegovy(semaglutideinjection):
•InitiationandDoseEscalation:Startwithalowdoseandgraduallyescalatetoamaintenancedose of24mgsubcutaneouslyonceweeklytominimizegastrointestinaladversereactions
•DoseAdjustment:Ifunabletotolerateadoseduringescalation,considerdelayingdoseescalation for4weeks.Ifunabletotoleratethemaintenancedoseof2.4mgonceweekly,atemporarydecrease to17mgonceweeklyispossibleforamaximumof4weeksAfter4weeks,increasebacktothe maintenancedoseof2.4mgonceweekly.Discontinueifnottoleratedafterthesecondattempt.
Pleasenotethattheaboveisforinformationalpurposesonly.Youmustfollowthespecificdosage instructionsprovidedbyyourhealthcareprofessional.Theywilldeterminetheappropriatedose basedonyourindividualneeds,medicalcondition,andresponsetotreatment
6.WhatisthedifferencebetweenWegovy,Ozempic andRybelus?
Themanysemaglutidebrandscomeinavarietyofformatsandareusedforvariouspurposes:
❶Aparticularpatientpopulationusesthesubcutaneousinjectablewegovy(forweightcontrol), whichisadministeredonceaweek.
❷Forindividualswithtype2diabetes,Ozempic(subcutaneousinjection)isusedinconjunction withdietandexercisetoreducebloodsugarlevelsTheriskofseriouscardiovasculareventslikea heartattackorstrokeisalsoreducedindiabetespeoplewhoalreadyhavecardiovasculardisease. Everyweek,asubcutaneousinjectionofOzempicisadministered
❸Rybelsus(tablet),whichistakenasatabletonceperday,isusedtoreducebloodsugarlevelsfor type2diabetespatientstogetherwithdietandexercise
Strength0.25mgor0.5mg dosepen,1mgdose pen,2mgdosepen.
UsesUsedtohelpcontrol bloodsugarlevelsin type2diabetic patients,itisused togetherwithdiet andexercise.Itis alsousedtoreduce theriskofmajor cardiaceventssuch asheartattackand strokesintype2 diabeticpatientswho alreadyhave cardiovascular disease.
0.25mgdosepen,0.5 mgdosepen,1mg dosepen,1.7mgdose pen,24mgdosepen
Usedforweightloss forpatientswhohave aninitialBMI(body massindex)of 30kg/m2orgreateror patientswhohavea BMIof27kg/m2or greaterandalsohave leastone weight-related condition,suchashigh bloodpressure,type2 diabetesandhigh cholesterolItisuse togetherwithdietand exercise.
3mgtablet,7mg tablet,14mgtablet
Usedtohelpcontrol bloodsugarlevelsin type2diabetic patients,itisused togetherwithdiet andexercise.
7.StoragerequirementsforSemaglutide?
•Priortofirstuse,Ozempicshouldbestoredinarefrigeratorbetween36ºFto46ºF(2ºCto8ºC). StoreawayfromthefreezerandthecoolingelementoftherefrigeratorOzempicshouldn'tbe frozen,andifithasbeenfrozen,itshouldn'tbeused.
•TheOzempicpencanbekeptinarefrigerator(36°Fto46°F;2°Cto8°C)oratregulatedroom temperature(59°Fto86°F;15°Cto30°C)for56daysafterthefirstusage.Avoidfreezing.
•Whennotinuse,keepthepencapon.Ozempichastobeshieldedfromthesunandextremeheat.
•Aftereachinjection,alwaysremovetheneedleandproperlydisposeofitStoretheOzempicpen withouttheneedleattached.Foreveryinjection,anewneedleshouldbeused.
https://www.polypeptide.ltd/
❷Wegovy
•Keepthesingle-dosepenbetween2°Cand8°C(36°Fand46°F)intherefrigerator.Thepencanbe storedat8°Cto30°C(46°Fto86°F)forupto28daysifnecessarybeforethecapisremovedAvoid freezing.KeepthelightoutforWegovy.Uptothetimeofadministration,Wegovymustbe maintainedintheoriginalcartonAfterusing,throwawaytheWegovypen
❸Rybelsus
•Storemedicationsbetween68°and77°F(20°and25°C);excursionsareallowedto59°to86°F (15°to30°C)[seeUSPControlledRoomTemperature].Intheoriginalbottle,keepandusethe contents.
•Topreventpillsfromabsorbingmoisture,keepthemintheiroriginalbottleuntiluse.Keepthis medicationdryandfreefrommoisturewhilenotinuse
8.Whatotherdrugswillaffectsemaglutide?
Yourdigestionmaybeslowedbysemaglutide,andyourbodymaytakelongertoabsorbanyoral medicationsyoutake.
Tellyourdoctoraboutallofyourothermedications,notablyinsulinandanydiabeticmedications youmaybetaking,includingByetta,Trulicity,Victoza,exenatide,dulaglutide,andliraglutide.
Semaglutidemayinteractwithothermedications,includingprescriptionandover-the-counter medicine,vitamins,andherbalproductsTellyourdoctorofallotherdrugsyouuse
9.WheretobuySemaglutidefrom?
Polypeptide.ltdisthereliablemanufacturerofSemaglutide,producesSemaglutidestrictlyaccording tocGMPstandards,andisequippedwithHPLC,GC,andotheranalyticalinstrumentsTestscanbe doneonIR,GC/MS,LC/MS,and400NMRattheSIOCthroughacontract.Customsynthesized peptide.Ithasafullyautomaticinjectionfillinglinewithmultiplefillingmodulesandabuilt-in freezedryer,whichcanfillvials,syringes,andcartridgesofvarioussizesandcanalsoproduce
CustomSynthesisPeptideManufacturers
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Referencecitations
[1]BjerreKnudsenL,MadsenLW,AndersenS,AlmholtK,deBoerAS,DruckerDJ,etal(April 2010)."Glucagon-likePeptide-1receptoragonistsactivaterodentthyroidC-cellscausingcalcitonin releaseandC-cellproliferation"Endocrinology151(4):1473–1486
[2]Jumpupto:abc"Rybelsus-oralsemaglutidetablet".DailyMed.Archivedfromtheoriginalon5 June2021Retrieved5June2021
[3]Jumpupto:abc"Wegovy-semaglutideinjection,solution".DailyMed.4June 2021Archivedfromtheoriginalon14December2021Retrieved11March2022
[4]DuttaD,KumarM,ShivaprasadKS,KumarA,SharmaM(June2022)"Impactofsemaglutide onbiochemicalandradiologicmeasuresofmetabolic-dysfunctionassociatedfattyliverdisease acrossthespectrumofglycaemia:Ameta-analysis"Diabetes&MetabolicSyndrome16(6): 102539doi:101016/jdsx2022102539PMID35709586S2CID249584781
[5]"TheTop300of2020"ClinCalcArchivedfromtheoriginalon18March2020Retrieved7 October2022.
[6]"Rybelsus–SummaryofProductCharacteristics(SmPC)"(emc)25November 2020.Archivedfromtheoriginalon6June2021.Retrieved6June2021.
[7]Jumpupto:ab"RybelsusEPAR".EuropeanMedicinesAgency(EMA).29January 2020Archivedfromtheoriginalon14August2020Retrieved26September2020
[8]Jumpupto:abc"WegovyEPAR".EuropeanMedicinesAgency.11November
2021.Archivedfromtheoriginalon2July2022.Retrieved11March2022.
[9]DanielGilbert(12June2023)"InsurersclampingdownondoctorswhoprescribeOzempicfor weightloss".TheWashingtonPost.
[10]PhillipsA,ClementsJN(February2022)"Clinicalreviewofsubcutaneoussemaglutidefor obesity".JournalofClinicalPharmacyandTherapeutics.47(2): 184–193doi:101111/jcpt13574PMID34964141S2CID245538758
[11]"Semaglutide–DrugUsageStatistics"ClinCalcArchivedfromtheoriginalon8October 2022.Retrieved7October2022.
[12]"FDAApprovesNewDrugTreatmentforChronicWeightManagement,FirstSince 2014".U.S.FoodandDrugAdministration(FDA)(Pressrelease).4June2021.Archivedfromthe originalon4June2021Retrieved5June2021
[13]"Wegovy:PendingECdecision".EuropeanMedicinesAgency.11November 2021Archivedfromtheoriginalon13November2021Retrieved13November2021Textwas copiedfromthissourcewhichiscopyrightEuropeanMedicinesAgency.Reproductionisauthorized providedthesourceisacknowledged
[14]MüllerTD,BlüherM,TschöpMH,DiMarchiRD(March2022)."Anti-obesitydrugdiscovery: advancesandchallenges"NatureReviewsDrugDiscovery21(3): 201–223.doi:10.1038/s41573-021-00337-8.PMC8609996.PMID34815532.
[15]ZhangS(19May2023)."DidScientistsAccidentallyInventanAnti-addictionDrug?".The Atlantic.Retrieved21May2023.
[16]CunhaJP,ed.(18January2023)."SideEffectsofWegovy(SemaglutideInjection),Warnings, Uses"RxList(partoftheWebMDnetwork)
https://www.polypeptide.ltd/