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Authoritativesource：PubChem
WhatdoesNootropicpeptideSelankdevelo pedinRussialooklike?
SelankPeptideStructure
SelankHistory
BulkSelankpeptideisasyntheticpeptidethatispopularinthenootropicmarketin recentyearsduetoitsnumeroushealthbenefitsBulkSelankwasdevelopedbythe InstituteofMolecularGeneticsoftheRussianAcademyofSciences.TheRussian nameofSelankpeptideisCеланк.
PeptideSelankpowderisasyntheticpeptidederivedfromtuftsinthatwasfirst discoveredin1983,andnamedafter“TuftsUniversity”
WhatIsSelank?
Selankpeptideisasyntheticcompoundderivedfromthenaturallyoccurring tetrapeptidetuftsin,whichisessentialforregulatingtheimmunesystem.Selankhas gainedpopularityforitsvarioushealthbenefits,includingenhancingcognitive function,reducinganxietyandstress,improvingmoodandsleep,andboostingthe immuneresponse.
Oneoftheprimarybenefitsofselankisitsabilitytoreduceanxietyandstresslevels ItachievesthisbystimulatingGABAreceptors,whichpromoterelaxationand calmnesswhilereducingtensionandrestlessness.Additionally,selankhelpsregulate cortisollevelsinthebody,whichareresponsibleforinducingstressresponses.
Furthermore,selankmaycontributetoimprovedmentalclarityandfocus,aswellas promotingbettersleepquality.Itisworthnotingthatwhileselankhasbeen approvedforuseinsomecountrieslikeUkraineandRussiafortreatinggeneralized
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anxietydisorder(GAD),itremainsoutsidethesupervisionandregulationoftheFood andDrugAdministration(FDA)intheUnitedStates.
WhatIsTuftsin?
Tuftsinwasfirstdiscoveredin1983,isanendogenouspeptidewhichisanaturally occurringcompoundinthehumanbody,thatalsoshowsanxiolyticeffects.Tuftsin peptidewasnamedafter“TuftsUniversity”.
Usually,theamountandconcentrationofthenaturaltuftsinpeptideinourbodies areminimal.However,whenthebodyisunderstress,itreleasesmoretuftsintosettle downthestressorandcalmthebody
Unfortunately,thelifespanoftuftsinisveryshort,nomorethanseveralminutes, meaningitseffectsonournervoussystemistransient.Toprolongtheeffectsof tuftsin,scientistsareworkingonanothersyntheticpeptidethatmimicsitbutwith higherstability.ThatisSelankpeptide.
HowDoesNootropicPeptideSelankWork?
Clinicalstudieshaveshownthesimilarityofthespectrumofphysiologicaleffectsof Selankandclassicalbenzodiazepines,suchasdiazepamandphenazepam.These datasuggestthatthereisasimilarbasisoftheirmechanismofaction.Hereishow doesthenootropicpeptideSelankwork.
Selankworkingmethod1:Immunomodulatory
Fromapurelypharmacologicalstandpoint,peptpideselankmimicsalotofthe effectsoftuftsinwhichistheendogenouspeptideitisbaseduponTheseeffects includethebalanceofThelpercellsandthemodulationoftheexpressionof Interleukin-6.
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Additionally,thereisevidencethatsuggestsnootropicselankmaymodulatethe expressionofbrain-derivedneurotropicfactor(BDNF).
ReferencedCitations
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[2]NarkevichVB,KudrinVS,KlodtPM,PokrovskiĭAA,KozlovskaiaMM,Maĭskiĭ AI,RaevskiĭKS(2008)"[Effectsofheptapeptideselankonthecontentofmono aminesandtheirmetabolitesinthebrainofBALB/CandC57Bl/6mice:acom parativestudy]".Eksperimental'naiaiKlinicheskaiaFarmakologiia.71(5):8–12.P MID19093364
[3]SemenovaTP,KozlovskiĭII,ZakharovaNM,KozlovskaiaMM(August2010)." [Experimentaloptimizationoflearningandmemoryprocessesbyselank]".Eksp erimental'naiaiKlinicheskaiaFarmakologiia.73(8):2–5.PMID20919548
[4]SemenovaTP,KozlovskiĭII,ZakharovaNM,KozlovskaiaMM(2009)"[Compari sonoftheeffectsofselankandtuftsinonthemetabolismofserotonininthe brainofratspretreatedwithPCPA]".Eksperimental'naiaiKlinicheskaiaFarmakol ogiia.72(4):6–8.PMID19803361
[5]InozemtsevaLS,KarpenkoEA,DolotovOV,LevitskayaNG,KamenskyAA,An dreevaLA,GrivennikovIA(2008)."IntranasaladministrationofthepeptideSela nkregulatesBDNFexpressionintherathippocampusinvivo".DokladyBiologi calSciences421:241–243doi:101134/s0012496608040066PMID18841804S2 CID40709909
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NF,ZozuliaAA(2001)."Semaxandselankinhibittheenkephalin-degradingenz ymesfromhumanserum".BioorganicheskaiaKhimiia(inRussian).27(3):180–1 83doi:101023/A:1011373002885PMID11443939S2CID26029820
[7]Solov'evVB,GenginMT,SollertinskaiaTN,LatynovaIV,ZhivaevaLV(2012)" [Effectofselankonthemaincarboxypeptidasesintheratnervoustissue]"Zh urnalEvoliutsionnoiBiokhimiiIFiziologii(inRussian).48(3):254–257.PMID22 827026
[8]SarkisovaKI,KozlovskiĭII,KozlovskaiaMM(2008)."[Effectsofheptapeptides elankongenetically-basedandsituation-provokedsymptomsofdepressionin behaviorinWAG/RijandWistarrats,andinBALB/cmice]".ZhurnalVyssheiNe rvnoiDeiatelnostiImeniIPPavlova(inRussian).58(2):226–237.PMID186617 85
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[10]Solov’evVB,GenginMT,SollertinskaiaTN,LatynovaIV,ZhivaevaLV(2012). “[Effectofselankonthemaincarboxypeptidasesintheratnervoustissue]”. ZhurnalEvoliutsionnoiBiokhimiiIFiziologii(inRussian)48(3):254–257PMID 22827026
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