Melanotan II Pharmaceutical Grade Raw Powder is Full in Stock! -By Polypeptide.ltd
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Introduction Polypeptide Melanotan II, also known as MT-2, is a synthetic version of the peptide hormone -melanocyte-stimulating hormone, which is a naturally occurring molecule in your body that is responsible for the creation of skin-darkening pigments known as melanin. It functions by attaching
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to melanocortin receptors. Melanotan 2 binds to MC-1R to promote skin and hair darkening. It also increases sexual excitement in women and encourages penile erection by tying to the MC-4R.
How does Melanotan II(MT2) Work on our body? Melanotan II is up to 1000 times more powerful than endogenous -MSH, attaching to melanocortin receptors to various degrees and causing a variety of effects. Melanotan-II (MT2) works by interacting with specific receptors in the body, primarily the melanocortin receptors, to produce its effects. Here is a list of the receptors involved: MC1R: Melanocytes, which produce pigment in the skin, hair follicles, and eyes, are the primary cells that express MC1R. The activation of MC1R by alpha-melanocyte-stimulating hormone (-MSH) promotes melanin production and distribution, resulting in skin and hair pigmentation. MC2R: It is present mostly in the adrenal glands, specifically in the outer layer known as the adrenal cortex. It is essential for the generation and release of cortisol, a hormone implicated in stress reactions and a variety of metabolic activities. MC3R: It is found throughout the central nervous system, including sites important in hunger regulation and energy balance, such as the hypothalamus. It is also prevalent in peripheral tissues such as the GI tract and adipose tissue.[3][4] MC4R: It is found mostly in the brain, notably in areas linked with hunger control, such as the hypothalamus. It is essential for controlling food intake and energy expenditure. Mutations in the MC4R gene have been linked to inherited forms of obesity. MC5R: MC5R is found in a variety of tissues, including the skin, hair follicles, immune cells, and exocrine glands. Its precise roles are currently being researched. It is worth noting that the MC1R is nearly entirely a pigment receptor that is present on cells where pigmentation is known to be significant, such as the eyes. To avoid the sunless tanning characteristics of melanocortins, it would be critical to avoid binding to this receptor. Though MT2 binds to MC1R with less affinity than MT1 or -MSH, it nevertheless binds and causes skin pigmentation. The MC3R, like the MC4R, is broadly distributed in the central nervous system. These two receptors are expected to be of considerable importance in the future since they are most likely to
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govern the effects of melanocortin on things like behavior. One of the primary goals of melanotan 2 and other melanocortin research is to understand how these receptors work and how they may be precisely targeted.
Reference citations [1] Wessells H, Levine N, Hadley ME, Dorr R, Hruby V. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9. doi: 10.1038/sj.ijir.3900582. PMID: 11035391. [2] Hadley, M. E., & Dorr, R. T. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides, 27(4), 921–930. [3] M. M. Sirufo, L. M. Magnanimi, L. Ginaldi, and M. De Martinis, “Anorexia nervosa and autoimmune comorbidities: A bidirectional route?,” CNS Neurosci. Ther., vol. 28, no. 12, pp. 1921–1929, Sep. 2022, doi: 10.1111/cns.13953. [4] Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol. 2004 Jul;182(1):123-32. doi: 10.1677/joe.0.1820123. PMID: 15225137. [5] Olney JJ, Sprow GM, Navarro M, Thiele TE. The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice. Neuropeptides. 2014;48(1):47-51. doi:10.1016/j.npep.2013.11.001. [6] Hjuler, K. F., & Lorentzen, H. F. (2014). Melanoma associated with the use of melanotan-II. Dermatology (Basel, Switzerland), 228(1), 34–36. [7] J. K. van den Heuvel et al., “Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets,” Front. Behav. Neurosci., vol. 9, p. 358, Dec. 2015, doi: 10.3389/fnbeh.2015.00358. [8] Zhang Y, Collazo R, Gao Y, Li G, Scarpace PJ. Intermittent MTII application evokes repeated anorexia and robust fat and weight loss. Peptides. 2010;31(4):639-643. doi:10.1016/j.peptides.2009.12.019.
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[9] Han D, Wang Y, Chen J, Zhang J, Yu P, Zhang R, Li S, Tao B, Wang Y, Qiu Y, Xu M, Gao E, Cao F. Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury. J Pineal Res. 2019 Aug;67(1):e12571. doi: 10.1111/jpi.12571. Epub 2019 Apr 12. PMID: 30903623. [10] Wang W, Guo DY, Lin YJ, Tao YX. Melanocortin Regulation of Inflammation. Front Endocrinol (Lausanne). 2019;10:683. Published 2019 Oct 9. doi:10.3389/fendo.2019.00683. [11]ANDAs for Certain Highly Purified Synthetic Peptide Drug Products That Refer to Listed Drugs of rDNA Origin (2021). [12]Krashes, M. J., Lowell, B://. B., & Garfield, A. S. (2016). Melanocortin-4 receptor-regulated energy homeostasis. Nature neuroscience, 19(2), 206–219. Author of this article: Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine. Scientific Journal paper Author: Mariël P Ter Laak Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands Joakim Riikonen Department of Physics and Mathematics, University of Eastern Finland, Kuopio, Finland Ryouichi Banno Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine Hiroshi Arima Department of Metabolic Diseases, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiyskaya Street, 125315 Moscow, Russia In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Polypeptide.ltd has no affiliation or relationship, implied or otherwise, with this
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physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this peptide.
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