Nicotinamide riboside chloride: Overview, benefits, dosage & side effects

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Nicotinamide riboside chloride: Overview, benefits, dosage & side effects What is Nicotinamide riboside chloride?

Nicotinamide riboside (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD +) precursor vitamin. The crystalline form of NR chloride is called NIAGEN, which is a synthetic form of nicotinamide riboside and a source from which nicotinamide in the form of nicotinic acid can be bioavailable and is generally considered safe (GRAS). NR chloride is the subject of two new dietary ingredient notices, which are mainly used in food supplements.

Nicotinamide Riboside Chloride is a natural ingredient that is found in milk. It is actually related to niacin and other forms of vitamin B3. Some researches have found that Nicotinamide Riboside Chloride have some unique characteristics that can boost one’s metabolism to help burn off more calories and prevent weight gain. In addition to weight loss, it also helps boost muscle performance, increase energy expenditure, and minimize the risk factors of diabetes.

Also, a research in humans has shown that both Nicotinamide Riboside Chloride raise NAD+ levels, which helps to ameliorate some age related conditions, although it is too soon to know yet how effective it will be.

How does Nicotinamide riboside chloride work?

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NAD+ is a vital substance for human life activities. Without it, your body will have various disease problems. Nicotinamide riboside is the precursor of NAD+, which is changed in the body to a chemical called NAD+. When NAD+ is lacking in the body, it produces NAD+ that makes the body return to normal work.

Taking nicotinamide riboside can help raise these low NAD+ levels, so as to maintain the normal operation of all parts of the body.

The benefits of Nicotinamide riboside chloride Nicotinamide riboside chloride is a synthetic form of nicotinamide riboside, its benefits/function is same as nicotinamide riboside. It participating in metabolism in the body, can be used to prevent pellagra or other niacin defection disease and to lower cholesterol and triglycerides in the blood. It is also used to lower the risk of heart attack in people with high cholesterol who have already had a heart attack.

Sometimes it is used to treat coronary artery disease(atherosclerosis), protect protect the brain and the liver (cardiovascular, diabetes, Alzheimer’s disease).

Besides, Nicotinamide riboside chloride also have other benefits in human: ♦Proper digestion and absorption of proteins and fats; ♦Help convert the essential amino acid tryptophan into niacin; ♦Reduce vomiting, and reduce results of taking antidepressants due to dry mouth and difficulty urinating; ♦Promote nucleic acid synthesis and prevent aging of tissues and organs, thereby achieving the purpose of delaying aging; 2

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♦Slow nocturnal muscle spasm, spastic paralysis and hand and foot neuritis; ♦Treatment of congenital hypometabolism and enhancement of metabolism; ♦Prevention and treatment of vitamin B6 deficiency; ♦Treatment of carpal tunnel syndrome; ♦Helps lose weight and strengthens muscle function. ♦Improve the body’s resistance to cancer cells ♦Prevent hearing loss ♦Is a natural diuretic.

Taking large doses can relieve drug addiction and have a good detoxification effect.

Improve the function of epidermal cells, as well as the functions of other cells in the human body, to keep the skin radiant.

How to take Nicotinamide riboside chloride?

Because Nicotinamide riboside chloride has beneficial medicine properties, it is often used as dietary supplements and medicine.

(1)Standard dose Nicotinamide riboside chloride is available in powder, tablet or capsule form in market, you can find it at some health-food stores, on Amazon or online retailers and supplement manufacturer.

In 2016, the nicotinamide riboside chloride supplement won the GRAS status. A year before, the FDA had approved of it as a source of niacin and a dietary ingredient at a daily dose of 180mg. Most NRC supplement brands recommend taking 180–300 mg 3

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per day, the equivalent of 1–2 capsules per day depending on the brand.

(2)How long does Nicotinamide riboside chloride therapy last?

Clinical studies have shown that NRC supplements can safely and effectively increase the level of NAD in the blood after 6-8 weeks. Researchers claim that people who take 300 mg of supplements daily for 8 weeks can increase NAD by 40-50%.

(3) Will there be any impact if it is too high or too low?

Although the side effects of NRC on the body are small, it does not mean that the more you use, the better. Studies have shown that patients who take 300 mg daily and 1000 mg daily have a significant increase in NAD+, and no significant difference between the two is found, so whether it is used for one month or 3 months or longer, take the dose of NRC only needs to be kept within the standard dose.

As for the dosage that is lower than the standard dosage, it may not achieve the effect you want.

Is there any side effects for Nicotinamide riboside chloride?

Nicotinamide ribose may be safe with few side effects.

In human studies, 1,000-2,000 mg daily has no harmful effects. However, some users have reported mild to moderate side effects, such as nausea, bloating, fatigue, headache, diarrhea, stomach upset, indigestion, or skin discomfort (such as itching and excessive sweating).

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Reference: [1]Conze D, Brenner C, Kruger CL. Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci Rep. 2019 Jul 5;9(1):9772. doi: 10.1038/s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.

[2]Bogan, K.L., Brenner, C. (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”.

Annu. Rev. Nutr. 28: 115–130. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.

[3]Chi Y, Sauve AA (November 2013). “Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection”. Curr Opin Clin Nutr Metab Care. 16 (6): 657–61. doi:10.1097/MCO.0b013e32836510c0. PMID 24071780.

[4]Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside – The Current State of Research and Therapeutic Uses.

[5]Martens, Christopher R., Blair A. Denman, Melissa R. Mazzo, Michael L. Armstrong, Nichole Reisdorph, Matthew B. McQueen, Michel Chonchol, and Douglas R. Seals.

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NADthplus in healthy middle-aged and older adults Nature Communications 9, no. 1 (March 2018). https://doi.org/10.1038/s41467-018-03421-7.

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