How does L-Ergothioneine (EGT) powder do on human health?

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

L-Ergothioneine (EGT) powder Specifications Product Name

L-(+)-Ergothioneine (EGT)

Chemical Name

ERGOTHIONEINE; L-Ergothioneine; Sympectothion; l ergothioneine

Brand Name

N/A

Drug Class

N/A

CAS Number

497-30-3

InChIKey

SSISHJJTAXXQAX-ZETCQYMHSA-N

Molecular Formula

C9H15N3O2S

Molecular Weight

229.3 g/mol

Monoisotopic Mass

229.088498 g/mol

Boiling point

N/A

Freezing Point

N/A

Biological Half-Life

N/A

Color

White or off-white powder

Solubility

Soluble in Water (up to 10 mg/ml)

Storage Temperature

−20°C

Application

l ergothioneine powder has used in healthy supplements

1

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

Overview L-ergothioneine is a naturally occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. This compound is made in relatively few organisms, notably Actinobacteria, Cyanobacteria, and certain fungi.

Ergothioneine requires a specific transporter, L-Ergothioneine (EGT), also known as OCTN1 (gene symbol SLC22A4), to enter cells. EGT expression has been confirmed in human and animal cell lines and its functional ability to transport ergothioneine has been confirmed in vivo.

L-ergothioneine is a naturally occurring amino acid and is a thiol/thione derivative of histidine. L-ergothioneine is found in highest concentrations in mushrooms and bacteria and in lower amounts in other foods including king crab, beef, pork, lamb, and chicken.

Despite the presence of L-ergothioneine in foods humans consume, its biosynthesis has only been observed in certain bacteria and fungi.

What is L-(+)-Ergothioneine (EGT) ?

L-Ergothioneine is an amino acid that is found mainly in mushrooms, but also in king crab, meat from animals that have grazed on grasses containing ergothioneine, and

2

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

other foods. Amino acids are chemicals that are the building blocks for proteins.

Ergothioneine is used as medicine.

People take ergothioneine for liver damage, cataracts, Alzheimer's disease, diabetes, and heart disease.

L-(+)-ERGOTHIO is a natural chiral amino-acid antioxidant biosynthesized in certain bacteria and fungi. It is an important bioactive compound which has been used as a radical scavenger, an ultraviolet ray filter, a regulator of oxidation-reduction reactions and cellular bioenergetics, and a physiological cytoprotector, etc.

L-Ergothioneine is sometimes applied directly to the skin to prevent wrinkles, reduce signs of aging skin, and reduce sun damage.

3

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

L-(+)-Ergothioneine (EGT) benefits

L-ergothioneine is exceptional in that it can reach the very core of certain cells such as erythrocytes, unlike other classic antioxidants such as vitamins C and E. It actually has a gene which codes for a carrier protein, enabling it to be taken right to the heart of cells. It is thus a potent intracellular antioxidant, as important as L-glutathione. In addition, it has also been shown to be a powerful chelator, enabling it to bind to toxic heavy metals, while protecting blood cells from all types of damage.

Encouraged by its antioxidant properties, researchers subsequently investigated its anti-inflammatory effects, since ergothioneine acts on, amongst others, the pro-inflammatory cytokine, interleukin. L-Ergothioneine (EGT) therefore has multiple properties actively working inside the human body:

 neutralizes reactive oxygen molecules (free radicals), thus combatting oxidative stress and reducing damage to mitochondrial DNA, oxidation of proteins and lipid peroxidation;  Chelates – or traps – various positive metallic cations;  Can activate antioxidant enzymes such as glutathione peroxidase or SOD, while inhibiting enzymes that generate the superoxide radical; 4

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

 Reduces oxidation of various haemoproteins such as hemoglobin and myoglobin;  Protects mitochondria;  L-ergothioneine reduces the harmful effects of UV rays, as a protective agent for Skin Care.  Preserves and maintains levels of other antioxidants such as vitamins C and E, glutathione and SOD;  Protects the brain from neurotoxins and thus plays a preventive role against cognitive decline;  Encourages cellular respiration and fat lipolysis, thus increasing energy and stamina for physical exercise;  When combined with hyaluronic acid, glucosamine, collagen, it was shown to significantly reduce joint pain and increase joint mobility, associated in particular with poor postural work habits, after just six weeks' use.

L-Ergothioneine (EGT) powder safety

Although l-ergothioneine shares a name and can come from ergot fungus, it's not poisonous in any way.

The European Union has stricter supplement standards than the United States and has determined that l-ergothioneine supplements are safe and produce no adverse 5

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

effects in adults and children over.

The Panel on Dietetic Products for the European Food Safety Authority finds that safe daily limits of 2.82 mg/kg of body weight for infants, 3.39 mg/kg for small children, and 1.31 mg/kg for adults, including pregnant and breastfeeding women.

L-(+)-Ergothioneine (EGT) powder uses and application Appropriate supplementation and/or an improved diet including longevity vitamins such as L-ergothioneine supplement may reduce much of the consequent risk of chronic disease and premature ageing.

6

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

L-ergothioneine powder is an ideal ingredient for a healthy ageing, nutraceutical formula.

Research suggests that L-ergothioneine antioxidant potential functions as an anti-inflammatory to further protect cells against physiological and neurodegenerative diseases.

1. Inflammation Research shows that as an antioxidant, L-ergothioneine might defend against inflammation.

Rheumatoid arthritis is an autoimmune disorder marked by intense (and often unexplained) inflammation.

It's possible that L-ergothioneine (EGT) may reduce inflammation in patients with rheumatoid arthritis.

2. Neurodegenerative Diseases As a cytoprotectant, L-ergothioneine (EGT) is a popular supplement among Alzheimer's and Parkinson's patients.

M-ergothioneine (EGT) supports your body's natural antioxidant defense system and may protect brain cells from oxidative damage and stress from free radicals.

By protecting brain cells, its plausible to prevent brain cell death in the first place and 7

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

protect against neurodegenerative diseases.

3. Liver Disease Thanks to its cytoprotectant and antioxidant potential, L-ergothioneine (EGT) is a favorite amino acid in patients with liver disease.

4. Anti-Aging Potential You'll often find L-ergothioneine (EGT) in many skincare products because of its cytoprotectant and antioxidant properties- which may protect skin cells from oxidative damage.

Free radical damage and oxidative stress are major contributors to premature aging, sagging skin, and wrinkles.

5. Lung Diseases The US Department of Defense awarded a $1.34 million grant to researchers at the University of Colorado to study EGT’s antioxidant action for fighting lung diseases in combat veterans.

Reference:

[1]. Oumari M, et al. Regeneration of ergothioneine after reaction with singlet 8

Email: info@phcoker.com

Phcoker

Xuchang shangke Chemical Co., Ltd

www.phcoker.com

oxygen. Free Radic Biol Med. 2019 Apr;134:498-504.

[2] Cheah, L.K., Halliwell, B. Ergothioneine; antioxidant potential, physiological function and role in disease, Biochim. Biophys. Acta 2012; (5): 784-793.

[3] Genghof, D. S. Biosynthesis of Ergothioneine and Hercynine by. Fungi and Actinomycetales, J. Bacteriol., 1970; 103(2): 475–478.

[4] Repine, J.E., Elkins, N.D. Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats, Prev. Med. 2012; (54): S79-S82.

[5] EFSA Panel on Dietetic Products, Nutrition and Allergies (2017). "Statement on the safety of synthetic l-ergothioneine as a novel food – supplementary dietary exposure and safety assessment for infants and young children, pregnant and breastfeeding women". EFSA Journal. 15 (11): 5060. doi:10.2903/j.efsa.2017.5060.

9

Email: info@phcoker.com