Can Alpha-GPC Improve Cognition?

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Can Alpha-GPC Improve Cognition?

What is Alpha GPC (Choline Alfoscerate) powder (28319-77-9)?

Alpha GPC is the common name for L-Alpha glycerylphosphorylcholine, a cholinergic nootropic that occurs naturally but can also be taken as a supplement. Alpha GPC powder is best known for quickly and reliably delivering choline to the brain for the creation of the cognition-boosting neurotransmitter acetylcholine.

It has powerful benefits for both brain and body and may enhance the full range of cognitive functions, promote cellular health, and help maintain essential neurochemical balance in the brain.

Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of acetylcholine. It is a non-prescription drug in most countries. The FDA determined that intake of no more than 196.2 mg/person/day is considered GRAS. In some European countries, it is regulated as a prescription drug and used for the treatment of Alzheimer’s disease.

How does Alpha GPC work? Mechanism of Action?

Alpha-GPC supports the whole nervous system by boosting acetylcholine and cholinergic activity. It may also raise the levels of other brain-protective messengers such as: GABA Dopamine Serotonin

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Inositol phosphate Plus, as mentioned, it might boost growth hormone levels as well.

Some potential benefits of Alpha GPC      

Improved Memory and Enhanced Cognition Neuroprotectant Improves Stroke Recovery Boosts Athletic Performance,Increased Strength and Rapid Post-Workout Recovery May Improve Eyesight May Protect Against Radiation

Alpha GPC recommended dosage Alpha GPC is about 40% choline by weight. So 1,000 mg of Alpha GPC powder provides approximately 400 mg of choline.

Alpha GPC suggested dosage for cognitive benefits is 250–1,200 mg per day. Here’s a breakdown of the dosing regimens: -- Alzheimer’s disease and dementia: 400 mg, 3X daily for 6 – 12 months.

-- Stroke recovery: 1,000 mg daily for 1 month (as injections).

-- 400 mg orally, 3X daily for 5 months afterward -- Athletic performance: 250 mg daily for 1 week [11] -- 600 mg daily for 1 – 6 days.

-- Eyesight: 400 mg, 2X daily for 2 months.

According to anecdotal evidence, the dose for nootropic effects ranges from 400 to 1,200 mg/day. You might want to start on the lower end and track your response.

Side effects of Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9) Alpha-GPC powder was safe in all clinical trials. In a fraction of patients, it caused mild side effects such as:  Heartburn  Nausea  Irritability  Headache In safety studies on dogs and rats, megadoses (up to 3,000 mg/kg) only slightly reduced the animals’ activity.

Researchers concluded that long-term (26 weeks) alpha-GCP consumption of 150 mg/kg (over 10 g daily for adult men) bears no health risks.

Due to the lack of safety data, children and pregnant women may want to avoid alpha-GPC.

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