PD Research Day Program 2026

2026

APRIL 15, 2026 Penn Dental Medicine 10:00am – 6:00pm

2026 WELCOME It is our great pleasure to welcome alumni, faculty, staff, students and friends to Penn Dental Medicine Research Day 2026.

We invite you to join us in celebrating as faculty, students, and research staff once again come together to showcase the breadth and strength of PDM’s research in a single venue. We look forward to a day of exchange and collaboration across disciplines that highlights the quality, depth, and diversity of the School’s research.

We warmly welcome this year’s keynote speakers. Jonathan Epstein, MD, Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System, will deliver the Joseph L. Rabinowitz Memorial Lecture, “Treating Fibrosis with mRNA and CAR T Cells.” Laurie McCauley, DDS, MS, PhD, Provost and Executive Vice President for Academic Affairs at the University of Michigan, will present the PDM Research Day Keynote Lecture, “A Journey in Hormonal Actions, Immunology, Bone Biology and Discovery Science.” We are honored to have you with us for this important day.

Another highlight of the day is the presentation of research awards recognizing excellence and innovation across our community. Among these is the Joseph and Josephine Rabinowitz Award for Excellence in Research, established in 1992 by the late Dr. Joseph Rabinowitz, a longtime member of the School’s Biochemistry faculty, and his wife, Josephine, to support independent and collaborative faculty research. Today, this tradition has grown to include a broader portfolio of awards that celebrate outstanding achievement and encourage interdisciplinary scholarship across Penn Dental Medicine.

Research Day will also recognize student and trainee accomplishments through a series of competitive awards and travel opportunities that support continued scholarly development. These include the AADOCR Student Research Day Award and the Student Competition for Advancing Dental Research and its Application (SCADA), as well as Penn Dental Medicine’s AADOCR Travel Awards, the Gail Schupak Travel Award, the Oral Cancer Award and the Vernon Brightman Award. Together, these programs provide critical support for students and junior investigators to present their work at national meetings, foster professional growth, and contribute to the future of dental research and discovery.

Penn Dental Medicine continues to build as a leader in the generation of new knowledge and in the cultivation of the next generation of oral health researchers. We hope the day will spark new collaborations, fresh insights, and continued innovation. Enjoy the day.

Mark S. Wolff, D.D.S, PhD Morton Amsterdam Dean

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Dana Graves, DDS, DMSc

Vice Dean for Scholarship and Research

RESEARCH DAY COMMITTEE Dr. Dana T. Graves Chair Dr. Esra Sahingur Co-chair Dr. Joseph Fiorellini Dr. Michael Glick Dr. George Hajishengallis Dr. Monica Chenshuang Li Dr. Rob Ricciardi Pamela Rice

SCHEDULE 9:55 AM

OPENING REMARKS Arthur E. Corby Auditorium

Dana T. Graves, DDS, DMSc

10:00 AM

PENN DENTAL MEDICINE FACULTY PRESENTATIONS Arthur E. Corby Auditorium

MODERATOR: Cagla Akay-Espinoza, MD

“Senescence, Inflammaging and Microbiome Axis in Periodontal Aging” Esra Sahingur, DDS, MS, PhD

Associate Dean of Graduate Studies & Student Research Associate Professor, Department of Periodontics

MODERATOR: Hyeran Helen Jeon, DDS, MSD, DScD

“Unraveling Clinical and Molecular Pathways of Periodontitis Progression” Flavia Teles, DDS, MS, DMSc

Professor, Department of Basic & Translational Sciences

MODERATOR: Yijing Su, PhD

“The Healing Blueprint: Enhanced Therapeutic Potentials of GMSCs” Anh D. Le, DDS, PhD

Chair and Norman Vine Endowed Professor of Oral Rehabilitation, Department of Oral & Maxillofacial Surgery/Pharmacology

11:00 AM THE JOSEPH L. RABINOWITZ MEMORIAL LECTURE Arthur E. Corby Auditorium

MODERATOR: Henry Daniell, PhD

“Treating Fibrosis with mRNA and CAR T cells” Jonathan Epstein, MD

ean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the D University of Pennsylvania for the Health System

12:00 PM

LUNCH Fonseca Gardens

12:45 PM

POSTER PRESENTATIONS AND COMPETITIONS Schattner Lobby, Lerner Pavilion, and Schattner Patient Waiting

2:45 PM

TRANSITION BREAK

3:00 PM

PDM RESEARCH DAY KEYNOTE LECTURE Arthur E. Corby Auditorium

MODERATOR: Alonso Carrasco Labra, DDS, MSc, PhD

“ A Journey in Hormonal Actions, Immunology, Bone Biology and Discovery Science” Laurie McCauley, DDS, MS, PhD Provost and Executive Vice President for Academic Affairs, University of Michigan

4:15 PM

RECEPTION, RECOGNITION AND AWARDS Fonseca Gardens

Esra Sahingur, DDS, MS, PhD RESEARCH DAY 2026 3

KEYNOTE SPEAKERS

PDM RESEARCH DAY KEYNOTE SPEAKER LAURIE McCAULEY, DDS, MS, PhD Provost and Executive Vice President for Academic Affairs University of Michigan Dr. Laurie McCauley serves as provost and executive vice president for academic affairs at the University of Michigan. Her leadership priorities have included student success, support for those with disabilities, and co-leading U-M’s Campus Planning and Strategic Visioning processes.

Dr. McCauley is a member of the National Academy of Medicine and a fellow of the American Association for the Advancement of Science. An NIH-supported researcher for over 25 years, her work focuses on bone biology and prostate cancer skeletal metastasis, contributing to regenerative medicine and treatments for bone loss.

Dr. McCauley is the former dean of the U-M School of Dentistry and the William K. and Mary Anne Najjar Professor of Periodontics as well as a professor of pathology in the Medical School.

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KEYNOTE SPEAKERS

THE JOSEPH L. RABINOWITZ MEMORIAL LECTURE JONATHAN EPSTEIN, MD Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System Jonathan A. Epstein, MD, serves as Dean of the Raymond and Ruth Perelman School of Medicine and Executive Vice President of the University of Pennsylvania for the Health System, together comprising Penn Medicine, an $11.9 billion enterprise dedicated to medical education, biomedical research, and patient care.

Founded in 1765, the Perelman School of Medicine is the nation’s first medical school and now includes more than 3,100 faculty and over 4,500 learners, with more than $1 billion in annual sponsored research. The University of Pennsylvania Health System features nationally ranked hospitals and a broad clinical network across primary and specialty care.

Dr. Epstein, a graduate of Harvard College and Harvard Medical School, completed his training at Brigham and Women’s Hospital and joined Penn in 1996. Over nearly three decades, he has held key leadership roles, including Executive Vice Dean and Chief Scientific Officer, helping to shape Penn Medicine into a global leader in research and innovation.

He holds the Robert G. Dunlop Professorship and previously chaired the Department of Cell and Developmental Biology, served as Scientific Director of the Penn Cardiovascular Institute, and co-founded the Penn Institute for Regenerative Medicine.

A leading physician-scientist, his research focuses on congenital heart disease, heart failure, stem cell biology, and epigenetics, with recent advances in mRNA-based therapies. His honors include the Sir William Osler Young Investigator Award and election to the American Academy of Arts and Sciences and the National Academy of Medicine.

RESEARCH DAY 2026 5

2026 JOSEPH AND JOSEPHINE RABINOWITZ AWARD RECIPIENTS Lauren C. Yap DMD, MPH

Clinical Assistant Professor, Assistant Program Director for Postdoctoral Pediatric Dentistry Program Department of Preventive and Restorative Sciences, Division of Pediatric Dentistry Oral Microbiome Changes in Children Placed on a Ketogenic Diet

JOSEPH AND JOSEPHINE RABINOWITZ AWARD FOR EXCELLENCE IN RESEARCH The Joseph and Josephine Rabinowitz Award for Excellence in Research was designed to help Penn Dental Medicine faculty undertake pilot projects that will enable them to successfully apply for extramural sources of funding. Designed through the lens of a researcher, this ongoing grant evaluates research proposals for their scholarly merit, creativity and innovation; the significance of the research in advancing scientific knowledge; the prospects for future extramural funding; the availability of alternate funding sources; and in the case of junior faculty, evidence that the applicant will be working as an independent investigator and forwarding of the School’s research objectives. It was under development as early as 1994 with the first award presented in 2002.

This award was endowed through the generosity of the late Dr. Joseph “Jose” Rabinowitz, an active member of the School’s biochemistry faculty for 29 years, and his wife, the late Dr. Josephine “Josy,” a fellow Penn alum.

Josy’s PhD was in the field of education. Her strong endorsement of education and research provided a hand in the development of this grant. Jose was known for his research in lipid and steroid biochemistry, and made the seminal discovery that HMG CoA was a key intermediate in cholesterol biosynthesis. His research helped lead to the development of the important class of cholesterollowering drugs known as statins.

The Rabinowitz family continues to support the values and priorities of this award and congratulates its newest recipients.

6 PENN DENTAL MEDICINE

The ketogenic diet is comprised of a high-fat, low-carbohydrate regimen used for weight management and therapeutic purposes in conditions such as epilepsy, Alzheimer’s disease, and type 2 diabetes. The objective of the study is to determine the effect of the ketogenic diet on the composition and functional potential of the dental plaque microbiome in children. By identifying microbial shifts and changes in metabolic pathways associated with a ketogenic diet, critical insight can be provided into the potential oral health implications of ketogenic dietary therapy. The link between carbohydrate consumption and the pathogenesis of dental caries is well-documented, however the impact of the ketogenic diet on oral ecology remains largely unexplored. This pilot study seeks to characterize changes in dental plaque microbial composition following the initiation of this diet regimen. By investigating these shifts, the project intends to unveil how dietary-induced ketosis modulates oral health, potentially informing novel diagnostic and therapeutic strategies for the pediatric populations.

Wenjing Yu, DDS, PhD, DScD, DMD

Assistant Professor, Associate Director of Predoctoral Orthodontics Program Department of Orthodontics The role of Gli1+ Chondroprogenitor Cells in Degenerative Temporomandibular joint (TMJ) Diseases Temporomandibular joint disease (TMD) is a degenerative musculoskeletal disorder that causes morphological and functional abnormalities. Degenerative Joint Disorders (DJD) of the temporomandibular joint (TMJ) represent a challenging and multifaceted group of conditions that severely impact the joint’s function and patient’s quality of life. Histologically, the DJD of the TMJ is caused by damage or breakdown of the joint cartilage between bones. Despite its prevalence and impact, there are no specific therapeutics that target its root cause. We hypothesize that a group of chondroprogenitor cells (CPC) plays a critical role in maintaining bone homeostasis and preventing the progression of degenerative joint disease in the TMJ. This proposed study aims to identify novel endogenous stem/progenitor cell sources for cartilage tissue regeneration, with a focus on Gli1+ CPCs, derived from the mandibular condyle, that exhibit cartilage regenerative capacity.

FACULTY PRESENTATIONS

RESEARCH DAY 2026 7

FACULTY PRESENTATIONS

Presentations SENESCENCE, INFLAMMAGING AND MICROBIOME AXIS IN PERIODONTAL AGING Esra Sahingur, DDS, MS, PhD

Associate Dean of Graduate Studies & Student Research Associate Professor, Department of Periodontics

This lecture explores the interplay between inflammation, cellular senescence, and the microbiome in periodontal aging.

It highlights how chronic inflammation and microbial dysbiosis drive senescence, leading to a cycle of “inflammaging” that contributes to periodontal disease progression and systemic health connections. The session also introduces emerging therapeutic strategies, including senotherapeutics, targeting senescence and inflammation to improve periodontal outcomes Educational Objectives •D escribe the role of cellular senescence and SASP in the pathogenesis of periodontal disease.

• E xplain the interactions between inflammation, microbial dysbiosis, and aging in periodontal tissues.

•D iscuss emerging senotherapeutic approaches and their potential impact on periodontal and systemic health.

UNRAVELING CLINICAL AND MOLECULAR PATHWAYS OF PERIODONTITIS PROGRESSION Flavia Teles, DDS, MS, DMSc

Professor, Department of Basic & Translational Sciences

Periodontitis is a complex, multifactorial inflammatory disease that results in the destruction of the tooth-supporting tissues and remains one of the most prevalent chronic conditions worldwide. Despite decades of research, the mechanisms that determine why some individuals experience rapid disease progression while others remain stable remain unclear. This lecture explores how integrative clinical and molecular approaches are reshaping our understanding of periodontitis progression, highlighting novel biomarkers, microbial signatures, and host–microbe interactions that define disease trajectories. Through a synthesis of clinical evidence and mechanistic insight, this lecture invites participants to reconsider periodontitis not as a static disease entity but as a dynamic process shaped by continuous host–microbial interactions. Understanding these pathways holds the promise of transforming diagnosis, monitoring, and treatment.

Educational Objectives •D escribe how integrative clinical and molecular approaches—such as longitudinal cohort studies and multi-omics analyses— enhance understanding of the mechanisms driving periodontitis progression and patient heterogeneity.

• E xplain the key biological pathways involved in periodontal tissue destruction and resolution failure, including the roles of host inflammatory mediators, complement activation, cellular senescence, and microbial dysbiosis.

• E valuate emerging translational tools and molecular biomarkers that support early detection, personalized risk assessment, and precision-based interventions in periodontal care.

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FACULTY PRESENTATIONS

THE HEALING BLUEPRINT: ENHANCED THERAPEUTIC POTENTIALS OF GMSCS Anh D. Le, DDS, PhD

Chair and Norman Vine Endowed Professor of Oral Rehabilitation Department of Oral & Maxillofacial Surgery/Pharmacology

Orofacial mesenchymal stem cells, easily accessible and enriched in neural crest properties, rapid proliferation, and multipotent differentiation, are excellent candidate cell sources for potential application in tissue engineering and regenerative therapy.

Our research group has extensively characterized mesenchymal stem cells derived from human gingival tissues (GMSCs) as unique stem cells for tissue engineering, soft and hard tissue regeneration, and immunomodulatory functions. Patient derived GMSC could be directly induced into multipotent NPCs (iNPCs) under minimally manipulated culture conditions without the introduction of exogenous genes. These induced GMSCs are also capable of releasing extracellular vesicles (EVs), including exosomes, with potent biological functions and therapeutic effects in several preclinical animal models, providing a safe cell-free therapeutic approach for tissue regeneration.

Educational Objectives •O rofacial MSCs have enriched neural crest properties •M SCs derived from gingival tissues (GMSCs) are capable of multipotent differentiation •M SCs have immunomodulatory functions

RESEARCH DAY 2026 9

FACULTY PRESENTATIONS

FACULTY AND JUNIOR INVESTIGATOR POSTERS

*Junior Investigators include the following categories: Masters students, DScD students, Residents, Postdocs, Research Associates and Junior Faculty

10 PENN DENTAL MEDICINE

RESEARCH DAY 2026 10

FACULTY AND JUNIOR INVESTIGATOR POSTERS RD-1

RD-4

RD-7

HIV Disrupts CD4-Dependent Oral Microbiome–Inflammation Crosstalk in Pediatric Caries

In-Vitro Comparative Study of Fit Accuracy Between Conventional, 3D‑Printed, and Hybrid Hollow Bulb Obturators Using Digital Superimposition and Heat‑Map Analysis

Treatment Planning for Periodontally Compromised Teeth: To Treat and Maintain or to Extract and Pursue Implant Therapy

Mohammad Alshemali1 Nupur Patel1,2,3, Brian M. Chang2,4,5,6, Francis Mante7, Yu-Chun Lin7, Harshiv Karia8, Sebastian Ollinger2

University of Pennsylvania School of Dental Medicine

Ibukun J. Abulude1, Aris Llada2, Allison Mann3, Sukhwinder Singh2, Esosa Osagie4, Paul Akhigbe4, Anil Kumar5, Ozoemene Obuekwe6, Vincent P. Richards7, Praise Okoh-Aihe5 Modupe O. Coker5,8,9 University of Pennsylvania School of Dental Medicine, Rutgers New Jersey Medical School, Department of Pathology, Immunology and Laboratory Medicine, 3 University of Wyoming, Department of Anthropology, 4 Institute of Human Virology Nigeria, International Research Centre for Excellence, 5University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 6University of Benin Teaching Hospital, 7Clemson University, Department of Biological Sciences, 8University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 9 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences 1

2

RD-2 mTOR Activation in Adipo-Precursor Remodels Marrow Niche and Bone Homeostasis Arwa Abumansour1, Xiaobin Huang1, Shilan Zhang2 Chider Chen3

University of Pennsylvania School of Dental Medicine, Department of Prosthodontics, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Advanced Education Program in Prosthodontics, 4University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 5 Hospital of University of Pennsylvania, Maxillofacial Prosthodontics, 6Hospital of University of Pennsylvania, The Penn Center for Innovative & Personalized Oral Rehabilitation, 7University of Pennsylvania School of Dental Medicine, 8University of Connecticut School of Dental Medicine 1

RD-5 Designing Bispecific Antibodies Targeting Glycoproteins gB and gD of Herpes Simplex Virus

1

Doina Atansiu1, Wan Ting Saw1 Harvey M. Friedman2,3, Gary H. Cohen1

2

1

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3 University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania Perelman School of Medicine, Division of Infectious Diseases, 3Penn Institute for RNA Innovation

RD-3

RD-6

Cross Kingdom Biofilm Analysis on Inlays and Onlays Construct of Piezoelectric Composite

Local Drug Delivery of 1,4 DPCA using PLGA Therapeutic Ligatures: A Novel Strategy for Periodontal Bone Regeneration.

Ahmed Alqalam1, Hyejoo Kim2, Pratik Nag2 Geelsu Hwang2,3,4

Lina Baeesa1, Jiaxin Liu1, Azamat Aslanukov2 Ellen Heber-Katz2, George Hajishengallis1

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

Mirza A. Baig

RD-8 Matrix Mechanics Regulate TumorMyeloid Crosstalk in Oral Squamous Cell Carcinomas Amanda S. Bluem1, Fathmeh Tavakoli Joorabi1,2, Yu-Chang J. Chen1,2 Kyle H. Vining2,3,4 University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 2 University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

RD-9 Antibody Responses to Key Epitopes in HSV-2 gC, gD and gE Fluctuate Over Time In Persons with Frequent Genital Recurrences Tina M. Cairns1, Lauren M. Hook2, Doina Atansiu1, Wan Ting Saw1, Christine Johnston3, Anna Wald3, Harvey M. Friedman2,4 Gary H. Cohen1 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania Perelman School of Medicine, Division of Infectious Diseases, 3University of Washington, Department of Medicine, 4Penn Institute for RNA Innovation 1

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 Lankenau Institute for Medical Research, Clinical Research 1

RESEARCH DAY 2026 11

FACULTY AND JUNIOR INVESTIGATOR POSTERS RD-10

RD-13

RD-16

Investigating the Mechano-Inflammatory Response of Dental Pulp Stem Cells Using 3D Artificial Extracellular Matrix

Reliability of Full-Arch Tooth-Supported Digital Impression and Accuracy of Selective Rescanning of Finish Line Under Lock Area Feature

Evaluation of an Injectable Zn–MOF Hydrogel for Antibacterial Treatment of Periodontal Infection

BingLing Chen1,2,3, Shuchen Zhang4, Jingyi Liu4,5,6, Hardikk Makkar4,6, Yu-Chang J. Chen5,7, Kyle H. Vining4,5,6,7 University of Pennsylvania School of Arts and Sciences, Department of Biology, 2Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 3University of Pennsylvania School of Dental Medicine, 4University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 5University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 6University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 7University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering 1

Selina Guo1 Nupur Patel1,2,3 University of Pennsylvania School of Dental Medicine, Department of Prosthodontics, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Advanced Education Program in Prosthodontics 1

RD-14

RD-11

Bacteria-Induced Cellular Redistrubiton of β-Catenin -E-Cadherin is Foxo1 Dependent and May Impact Barrier Function

Matrix Stress Relaxation Regulates the Functions of Stem Cell-Derived Dendritic Cells

Yu Jung Heo1, Minyoung A. Kwon2,3, Styliani Alimperti4,5 Dana T. Graves1,6,7

Yu-Chang J. Chen1,2, Nghi M. Tran2, Shuchen Zhang3, Amanda S. Bluem2, Fathmeh Tavakoli Joorabi1,2, Kexin Zhang1, Hardikk Makkar3,4 Kyle H. Vining1,3,4 University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 2University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

RD-12 Transcriptomic Profiling of Host Immune Responses to Aggregatibacter actinomycetemcomitans Leukotoxin and Cytolethal Distending Toxin Using Bulk RNA Sequencing Rebecca Choi1 Kathleen Boesze-Battaglia2, Anuradha Dhingra2, Bruce Shenker2, John Tobias3, Taewan Kim1 University of Pennsylvania School of Dental Medicine, Department of Periodontics, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Science, 3University of Pennsylvania Perelman School of Medicine, Department of Bioinformatics 1

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University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania School of Dental Medicine, 3 Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 4University of Georgetown, Translational Medicine, 5Georgetown University, Biochemistry and Molecular & Cellular Biology Academic Department, 6 University of Pennsylvania School of Dental Medicine, Department of Periodontics, 7University of Pennsylvania Perelman School of Medicine, The Penn Center for Musculoskeletal Disorders 1

RD-15 Salivary Metagenomic Signatures Reveal Early Microbial Predictors of Periodontitis Progression and Stability Cecilia C. Horchos1,2,3, Evelyn Santana3, Weiming Hu4,5, Kyle Bittinger5, Lynn Martin3,6 Flavia R.F. Teles2,3,6 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 2 University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4Children’s Hospital of Philadelphia, Research Institute, 5Children’s Hospital of Philadelphia, Microbiome Center, 6University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

Jiayi Kang1, Keyu Chen2, Marco Tizzano3,4, Matteo Tizzano5, Flavia Teles4, Jiaxin Liu4, Jingyi Liu1,6,7, Rima Amin5 Kyle H. Vining6,7,8 University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 2 University of Michigan, Department of Materials Science and Engineering, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 4University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 5University of Pennsylvania School of Dental Medicine, 6University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 7University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 8University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering 1

RD-17 Microstructural, Optical, and Mechanical Characterization of a New Dental Ceramic: Zpex4.m Yttria-Stabilized Zirconia Min Joo Kim1, Zheng Li2,3 Yu Zhang2,3 University of Pennsylvania School of Arts and Sciences, Department of Biology, 2University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences 1

RD-18 Inflammatory Profile After Third Molar Extraction is Associated with Supplemental Opioid Use Miguel A. De Leon1, Stacey A. Secreto1,2, Gaurav Gupta3, Steven Wang1,4, Neeraj Panchal1, Brian P. Ford1, John T. Ford5, Elliot V. Hersh1, Tilo Grosser6 Katherine N. Theken1 University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, 4University of Pennsylvania Perelman School of Medicine, Department of Oral and Maxillofacial Surgery, 5University of Pennsylvania Perelman School of Medicine, 6Bielefeld University 1

FACULTY AND JUNIOR INVESTIGATOR POSTERS RD-19

RD-23

RD-26

DEL-1 is a Novel Endogenous Senolytic Protein that Inhibits SenescenceAssociated Bone Loss

Potential Causes and Management of External Cervical Resorption in a Previously Endodontically Treated Tooth: A Case Report

Pain as Pathology and Prognosticator: Management in Oral and Maxillofacial Surgery

Jong-Hyung Lim University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

Angélica Medina Montañez Meeta Chawla University of Pennsylvania School of Dental Medicine

RD-20 Oral Microbiome Changes in Children Placed on a Ketogenic Diet

RD-24

Amy S. Lin1, Lauren Yap1,2, Yuan Liu3, Evlambia Hajishengallis1,2 University of Pennsylvania School of Dental Medicine, Department of Clinical Pediatric Dentistry, 2Children’s Hospital of Philadelphia, Department of Pediatrics, 3 Maurice H. Kornberg School of Dentistry at Temple University, Department of Oral Health Sciences 1

Biomechanical Assessment of ImplantSupported Prostheses in Fibula Free Flap Jaw-in-a-Day Reconstruction Using Finite Element Analysis Dina Mesmar1,2, Won Joo3, Brian M. Chang1,4,5,6 Nupur Patel1,2,7, Brian P. Ford4,8,9 University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Dental Medicine, Advanced Education Program in Prosthodontics, 3Robert Morris University, School of Engineering and Science Engineering, 4University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 5 Hospital of University of Pennsylvania, Maxillofacial Prosthodontics, 6Hospital of University of Pennsylvania, The Penn Center for Innovative & Personalized Oral Rehabilitation, 7University of Pennsylvania School of Dental Medicine, Department of Prosthodontics, 8 Philadelphia VA Medical Center, 9Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

RD-21 Sublingual Caruncle Taste Buds drive Taste Perception and Salivary Reflexes Jiaxin Liu1, Ranhui Xi1 Marco Tizzano1,2 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

RD-22

RD-25

The ECM-Cytoskeletal-Nuclear Axis Regulates Gingival Immune Homeostasis Through Stiffness-Dependent Nuclear Compaction and DNA Methylation

The Upside Down and Restorations: Stranger Biofilms on HydroxyapatiteBased Tooth Models

Hardikk Makkar , Vinayak Vinayak , Kang I I. Ko , Rebecca G. Wells6,7, Vivek B. Shenoy3,7 Kyle H. Vining1,2,3 1,2

3

4,5

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 5University of Pennsylvania School of Dental Medicine, Department of Periodontics, 6University of Pennsylvania Perelman School of Medicine, Department of Gastroenterology, 7Center for Engineering Mechanobiology 1

Pratik Nag1, Hyejoo Kim1 Geelsu Hwang1,2,3 University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

Richard Ni1, Monica Shen2 Brian P. Ford1,3,4 University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, 3Philadelphia VA Medical Center, 4 Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

RD-27 Identifying Early Biomarkers Linking Periodontal Inflammation and Alzheimer’s Disease Madison Orr1, Evelyn Santana2, Flavia R.F. Teles2,3,4 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Periodontics, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

2

RD-28 Single-cell Spatial Transcriptomics Unveil Pathologic Signatures of Inflamed Peri-Implant Free-Flaps Kawintip Prasongyuenyong1, Brian Kim2, Neeraj Panchal3, Brian P. Ford3, Faizan Alawi4,5 Kang I I. Ko1,6 University of Pennsylvania School of Dental Medicine, Department of Periodontics, 2University of Pennsylvania School of Dental Medicine, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 4 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 5 University of Pennsylvania School of Dental Medicine, Department of Academic Affairs, 6University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

RESEARCH DAY 2026 13

FACULTY AND JUNIOR INVESTIGATOR POSTERS RD-29

RD-32

RD-34

Maladaptive Trained Immunity: A Novel Link Between Metabolic DysfunctionAssociated Steatohepatitis and Periodontal Bone Loss

ECM Stress Relaxation Drives Tumor Invasion and Immune Evasion Through YAP/TAZ and TGF-β Signaling

Inter-Individual Variability in Ibuprofen Analgesia is Associated with Neutrophil PGE2 Production Capacity

Fathmeh Tavakoli Joorabi1,2, Amanda S. Bluem2, Dayoon Chang3, Yu-Chang J. Chen1,2 Kyle H. Vining1,3,4

Heba Turkstani1, Miguel A. De Leon2, Berlinda Beauvais2,3, Naser Alkandari1,4, Stacey A. Secreto2,5, John B. Lankalis2, Steven Wang2, Brian P. Ford2, Joseph A. Foote2, Neeraj Panchal2, Elliot V. Hersh2 Katherine N. Theken2

Gundappa Saha1, Jonathan Korostoff2, Triantafyllos Chavakis3 George Hajishengallis1 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3Technische Universität Dresden, Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine 1

RD-30 Establishment of a Biorepository Based on a Longitudinal Study of Periodontitis Progression: PerioPredict Biobank (P2B) Evelyn Santana , Lynn Martin Flavia R.F. Teles1,2,3 1

1,2

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3 University of Pennsylvania School of Dental Medicine, Department of Periodontics 1

RD-31 Longitudinal Effects of Simulated Dental Wear in Human Molars Carinna Solano Vargas1, Diego Contreras2,3, Kristin L. Krueger4, Gavin Hale5, Lillian Befeler5 Myra F. Laird2,6 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3 McGill University, 4Loyola University Chicago, Department of Anthropology, 5Loyola University Chicago, 6University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 2University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3 University of Pennsylvania, 4Kuwait University Faculty of Dentistry, Department of Diagnostics, 5University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

RD-33 Precision Local Delivery of mRNA to Dental Pulp Utilizing Bisphosphonate Conjugated Ionizable Lipid

RD-35

Jed Thussananutiyakul1,2,3, Jingyi Liu2,4,5, Ilchul Yoon2, Fatma Fenesha6, Gabriella Wandling6 Michael J. Mitchell4, Sarah B. Peters6, Kyle H. Vining2,5,7

Xudong Wang George Hajishengallis

University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 2University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 4University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 6The Ohio State University, College of Dentistry, 7University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering

Hematopoietic Stem Cell Aging as a Driver of Inflammatory Bone Loss

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

1

RD-36 Nanoarchitected Platforms for Targeted Enzyme Delivery Toward Cross-Kingdom Biofilm Inhibition Ilchul Yoon1, Hyejoo Kim1 Geelsu Hwang1,2,3 University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

RD-37 Voluntary Physical Exercise Modulates Hematopoiesis and Attenuates Periodontitis Ying Zhou George Hajishengallis University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

14 PENN DENTAL MEDICINE

STUDENT POSTERS

STUDENT POSTERS RD-41

RD-44

RESEARCH HONORS

Acetaldehyde-Induced DNA Damage: The Oral Microbiome’s Carcinogenic Role

RD-38

Yesul Kang1 Flavia R.F. Teles1,2,3, Evelyn Santana1

Targeted Delivery of STAT3-siRNA Using a Mineralized Tissue-Targeting Expression System (MiTEX) for Periodontal Disease Therapy

DMD STUDENT

Viscoelasticity of Surrounding Matrix Regulates Oral Cancer Spheroid Growth Dayoon Chang1, Fathmeh Tavakoli Joorabi2,3, Yu-Chang J. Chen2,3, Amanda S. Bluem3 Kyle H. Vining1,2,4 University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

RD-39 A Small Synthetic molecule Reduces Pro-Inflammatory Cytokines in a Ligature-Induced Periodontitis Model Aleena S. Defreitas1, Taewan Kim2, Anuradha Dhingra3 Kathleen Boesze-Battaglia3 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences

University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2University of Pennsylvania School of Dental Medicine, Department of Periodontics, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

RD-42 Compensatory E-Cadherin Remodeling Following Bacterial Challenge in the Oral Epithelium Minyoung A. Kwon1,2, Yu Jung Heo3, Styliani Alimperti4,5 Dana T. Graves3,6,7 University of Pennsylvania School of Dental Medicine, Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4University of Georgetown, Translational Medicine, 5Georgetown University, Biochemistry and Molecular & Cellular Biology Academic Department, 6University of Pennsylvania School of Dental Medicine, Department of Periodontics, 7University of Pennsylvania Perelman School of Medicine, The Penn Center for Musculoskeletal Disorders 1

2

Eliana (Nhi) Diep1, Serena C. Liu2 Daniell Henry2,3 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

16 PENN DENTAL MEDICINE

RD-45 Antimicrobial Peptide Suppression of Carcinogenic Acetaldehyde Production in OSCC Patients Serena C. Liu1, Geetanjali Wakade2 Daniell Henry1,2 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

Antimicrobial Therapeutic Strategies Targeting Carcinogenic Acetaldehyde Production by Polymicrobial Oral Cocultures in Oral Squamous Cell Carcinoma

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Department of Periodontics, 5 University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 6University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 7 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

1

RD-40

Yuantong (Rachel) Li1, Jingyi Liu1,2,3, Doris Chen1,4, Hardikk Makkar1,3, Yu-Chang J. Chen2,5, Jed Thussananutiyakul1,6,7, Shuchen Zhang1 Kyle H. Vining1,2,3,5

RD-43 Optimization and Standardization of Human Peripheral Blood Mononuclear Cell (PBMC)–Derived Macrophage Culture for Reproducible Inflammatory Analyses Yin-Chu (Ingrid) Lai , Katherine Baek , Miguel A. De Leon2, Berlinda Beauvais2,3, Stacey A. Secreto2,4, Katherine N. Theken2 1

1

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3University of Pennsylvania, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

RD-46 Panoramic Radiographs for Bone Fragility Screening in PWH Stephanie Moga1, Kevin Fan1, Praise Okoh-Aihe1, Adeyinka Dayo2, Mel Mupparapu2 Temitope T. Omolehinwa1,2 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 2 University of Pennsylvania School of Dental Medicine, Department of Oral Medicine 1

STUDENT POSTERS RD-47 Progressive Partially Methylated Domain Erosion and Targeted ZNF471 Silencing Define Two Independent Epigenetic Programs in Oral Premalignancy Michael E. Troka James C. Gates2

1

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

RD-48 Exploring Sex-Dimorphism in Periodontitis Severity and Progression Amy M. Wong1, Michael J. Kallan2 Flavia R.F. Teles3,4,5 University of Pennsylvania School of Dental Medicine, 2 University of Pennsylvania Perelman School of Medicine, Center for Clinical Epidemiology and Biostatistics, 3University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4University of Pennsylvania School of Dental Medicine, Department of Periodontics, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

DMD STUDENT

RD-52

SUMMER RESEARCH

Topical Delivery of mRNA Therapeutics to Dentin Using Lipid Nanoparticles

RD-49

Jimmy Cheng1, Jed Thussananutiyakul2,3,4, Ilchul Yoon3, Michael J. Mitchell5 Kyle H. Vining3,6,7

Spatial Distribution of Streptococcus mutans and Candida albicans Biofilms on 3D-Printed Molar Models Sachet Amin1 Pratik Nag2, Geelsu Hwang2,3,4 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

RD-50 Quercetin Inhibits MRGPRX2-Mediated Mast Cell Activation; Implication for Periodontal Disease Bahar Azadi1,2 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 2 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences 1

RD-51 Transforming Dental Restorations with Embedded BTO-AU Nanoparticles Victoria Chan1, Ilchul Yoon2, Pratik Nag2 Geelsu Hwang2,3,4 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 5University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 6University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 7University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering 1

2

RD-53 The Role of YAP/TAZ in Bone Marrow Mesenchymal Stem Cells Kaining (Kenny) Feng1 Chider Chen2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

RD-54 Effect of Osteoarthritis on Peri-Implantitis Edwin Lee University of Pennsylvania School of Dental Medicine

RD-55 Application of Shikonin for Targeted Inhibition of OSCC Cell Viability and Related Tumor-Associated Macrophages Zicong Li1 Qunzhou Zhang2, Ahn D. Le2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

RESEARCH DAY 2026 17

STUDENT POSTERS RD-56

RD-59

RD-63

Reprogramming M2-like Tumor Associated Macrophages by TLR7/8 Agonists Towards M1-like Phenotypes in Oral Cancer

Braces vs Clear Aligners: A Comparative Study on Surgical Morbidity in Orthognathic Surgery

Bite to Bolus: Understanding Food Particle Breakdown and Chewing Efficiency

Christina Li Qunzhou Zhang, Anh Le, Shihong Shi

Amanda Mavricos , John Button , Gina Chryssofos3 Brian P. Ford1,4,5

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

RD-57 Ferroptosis Drives Pro-Inflammatory Macrophage and Neutrophil Activation in Experimental Periodontitis and is Suppressed by UAMC-3203 Annabella Li1, William S. Kim2, Yeriel Yoon2 Kang I. Ko2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Periodontics 1

2

RD-58 Antibiofilm Impact of Barium Titanate-Gold Nanoparticle Coating on Tooth Surfaces Emily Luo1 Geelsu Hwang2,3,4 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

1

1,2

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 3University of Pennsylvania School of Dental Medicine, 4Philadelphia VA Medical Center, 5Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

RD-60 MRGPRX2-Dependent Mast Cell Activation

by Antimicrobial Polymers for Oral Immunity Harsha Meduru University of Pennsylvania School of Dental Medicine

RD-61 Natural Flavonoid Fisetin Mitigates Cellular Senescence in Gingival Epithelial Cells Jeslyn Mei1, Jenna M. Fattore2, Samuel F. Suslavich3, Megi G. Hysa3,4,5, Xia-Juan Xia3, S Esra S. Sahingur3 University of Pennsylvania School of Dental Medicine, University of Tampa, 3University of Pennsylvania School of Dental Medicine, Department of Periodontics, 4University of Pennsylvania School of Arts and Sciences, Department of Biology, 5University of Pennsylvania 1

2

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 5 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences 1

RD-64 TSC’s Proliferative and Differentiation Properties for Tissue Regeneration Gina J. Oh1 Chider Chen2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

RD-65 Topography-Dependent Cross-Kingdom Biofilm Formation on Hydroxyapatite Tooth Models Rachel Park University of Pennsylvania School of Dental Medicine

RD-66

RD-62

Condylar Changes in Temporomandibular Joint Development in Mice Animal Models

Effect of Immediate Implant Bone Augmentation of Post-Op Inflammatory Conditions

Renali Patel1, Shilan Zhang2 Wenjing Yu3

Sean Moran University of Pennsylvania School of Dental Medicine

18 PENN DENTAL MEDICINE

Artie P. Nayak1, Amy M. Wong1, Stephanie L. Canington2, Taylor Rutigliano1, Geelsu Hwang2,3,4 Myra F. Laird2,5

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3 University of Pennsylvania School of Dental Medicine, Department of Orthodontics 1

2

STUDENT POSTERS RD-67

RD-70

RD-73

Microplastic Exposure as an Emerging Risk Factor for Cardiovascular Disease and Diabetes Mellitus

Preoperative Psychological Predictors of Outpatient Pain Trajectory Post-ThirdMolar Extraction

Investigating the Impact of MechanoEducated Dendritic Cells on OSCC Response to Anti-PD1 Therapy

Parth Patel1 Hyeran Jeon2

Natalie H. Wang1, Emily F. Shekhtman1, Steven Wang2,3, Stacey A. Secreto3,4, Rania A. Habib3, Brian P. Ford3,5,6, Neeraj Panchal3, Elliot V. Hersh3 Katherine N. Theken3

Shuchen Zhang1, Amanda S. Bluem2, Fathmeh Tavakoli Joorabi2,3, Kexin Zhang3 Yu-Chang J. Chen2,3, Kyle H. Vining1,2,3,4

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Orthodontics 1

2

University of Pennsylvania School of Dental Medicine, 2 University of Pennsylvania Perelman School of Medicine, Department of Oral and Maxillofacial Surgery, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 5Philadelphia VA Medical Center, 6Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

RD-68 Utilization of Enzyme-Loaded Nanocarriers to Disrupt Oral Biofilms Dhruvi Patel1 Geelsu Hwang2,3,4 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

2

RD-69

Mesenchymal Stem Cell Behaviors during Rapid Maxillary Expansion Lia Wilmoth1 Wenjing Yu2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Orthodontics 2

Connor Riesenberger , Longfei He Yu Zhang2,5 1

2,3,4

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 Stomatological Hospital of Weifang People’s Hospital, Department of Pediatric Dentistry, 4Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 5 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences 2

RD-71

1

Flexural Strength of Compositional Gradient Multilayer Zirconia under High-Speed Sintering

1

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 3 University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

RD-72 Osteoblast-specific FoxO1 Deficiency Mitigates T2DM-Induced Bone Loss You (Grace) Wu1, Yang Yang2, Longyu Li2, Abdulaziz Hakeem2,3,4, Shuting Yang2 Dana T. Graves2,5,6, Shuying Yang2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3Umm Al Qura University School of Dentistry, Department of Basic and Translation Science, 4University of Pennsylvania Perelman School of Medicine, Department of Orthopaedic Surgery, 5University of Pennsylvania School of Dental Medicine, Department of Periodontics, 6University of Pennsylvania Perelman School of Medicine, The Penn Center for Musculoskeletal Disorders 1

2

RESEARCH DAY 2026 19

STUDENT POSTERS DMD STUDENT

OTHER RESEARCH RD-74

RD-77

RD-81

Full Pulpotomy Versus Root Canal Treatment in Mature Permanent Teeth with Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-Analysis

Relationship Between Adipokines and Opioid Use Following Third Molar Extraction Nicole M. Farkouh1, Camille Jordan1,2, Stacey A. Secreto3,4, Steven Wang4,5, Rania A. Habib4, Brian P. Ford4, Neeraj Panchal4, Elliot V. Hersh4 Katherine N. Theken4

Association Between Obstructive Sleep Apnea and Postoperative Opioid Utilization After Orthognathic Surgery: A Retrospective Cohort Study

Seowon Chang

Ryan A. Alt1, John Button2, Amanda Mavricos1 Brian P. Ford1,3,4

Individual Patient Solutions (IPS) Implants® Preprosthetic for Complex Dental Rehabilitation: An Alternative Treatment Modality

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Arts and Sciences, Department of Biology, 3University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 4University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 5University of Pennsylvania Perelman School of Medicine, Department of Oral and Maxillofacial Surgery

Dylan M. Crann1 Brian P. Ford1,2,3

RD-82

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2Philadelphia VA Medical Center, 3 Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery

MOLAR Audit Study: Evaluating Access to Dental Care Across Public and Private Insurance

University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 2University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 3Philadelphia VA Medical Center, 4Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

University of Pennsylvania School of Dental Medicine

RD-78

1

RD-75 Effect of Polishing Methods on Surface Roughness and Gloss of Additive Manufactured Restorative Materials

RD-79 Quantifying Epigenetic Aging Acceleration Among Individuals with and without HIV

University of Pennsylvania School of Dental Medicine, University of North Carolina at Chapel Hill, Adams School of Dentistry, Department of Restorative Sciences

Sonia Dalal1, Anil Kumar2, Peter Kavecky2, Yijing Su3, Temitope T. Omolehinwa2,3, Modupe O. Coker2,3,4

2

RD-76 Identifying Meaningful Potentially Modifiable Metabolic Abnormalities in Oral Cancer Patients Gabriella N. Casiano, Dylan M. Crann James C. Gates University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

University of Pennsylvania School of Dental Medicine, 2University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 4University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences 1

RD-80 Microbial Community Patterns in Medication-Related Osteonecrosis of the Jaw: A Culture-Based Analysis Taylor M. DeVine1, Ryan Elder1, Srighana Nadella2 Katherine N. Theken2, Neeraj Panchal2, Puhan He2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

20 PENN DENTAL MEDICINE

2

Sonia Gazula, Alyssia Liu, Heather Loo

Helen Alvis1, Tariq Alsahafi2 Taiseer Sulaiman2 1

1

University of Pennsylvania School of Dental Medicine

RD-83 Variation in Fiber Type Phenotypes Across Development in the Chewing Muscles of Sapajus Julia M. Gerstman1, Myra F. Laird2,3, Megan A. Holmes4 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research, 3 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 4Duke University School of Medicine, Department of Family Medicine and Community Health 1

2

STUDENT POSTERS RD-84

RD-87

RD-90

Grinding Out the Details: How Wear Reshapes Tooth Morphology

Detection and Control of Hydrogen Sulfide Produced by Oral CancerAssociated Bacteria

GIMAP6 is a Novel Regulator of Osteoblast-Mediated Bone Formation

Shahd L. Habeb1, Diego Contreras1,2, Tucker Sprayberry1, Stephanie L. Canington1, Kristin L. Krueger3 Myra F. Laird1,4 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2McGill University, 3Loyola University Chicago, Department of Anthropology, 4University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

RD-85 A Holistic Analysis of the Association Between Temporomandibular Disorders, Obstructive Sleep Apnea, and Psychosocial Conditions: A Review of Literature Farraz Haider1, Issa Elabed2, Allison Lo2, Taylor M. DeVine2, Anna-Maria Haddad2, Rubba Al-Kafaji2, Mohammad Asfour2, Mutasem Al Jariri2, Hadi Bouali3 Stefania Brazzoli1 University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

RD-86 Preoperative Orthodontic Measures of Overjet and Overbite as Predictors of Anesthesia Time, Operative Time, and Complications in Orthognathic Surgery Matthew Halpert1,2, Jasmine Shokri1,2, John Button2,3, Amanda Mavricos2 Brian P. Ford2,4,5 University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3 University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 4Philadelphia VA Medical Center, 5Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

Korrie Han1, Serena C. Liu1 Daniell Henry1,2 University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research 1

RD-88 Impacts of Intimate Partner Violence on Head and Neck Health and Survivors’ Healthcare Experiences Lauren A. Hogstrom1, Carolina Guillen1, Lilian Arce1, Maggie Junkin2 Katherine A. France3,4 University of Pennsylvania School of Dental Medicine, Maurice H. Kornberg School of Dentistry at Temple University, 3University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 4University of Pennsylvania School of Dental Medicine, Care Center for Persons with Disabilities 1

2

RD-89 Targeting the STAT3 Signaling Pathway to Modulate Inflammation and Enhance Regenerative Potential in Dental Pulp Stem Cells Seoyun Jang1, Shuchen Zhang2, BingLing Chen1,3,4 Kyle H. Vining2,5,6 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Arts and Sciences, Department of Biology, 4Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 6University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering 1

John Kim1, Abdulaziz Hakeem1,2,3, Tarun Sama1, Shuting Yang1, Ken Chen1 Shuying Yang1 1University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 2Umm Al Qura University School of Dentistry, Department of Basic and Translation Science, 3University of Pennsylvania Perelman School of Medicine, Department of Orthopaedic Surgery

RD-91 From Accommodation to Standard of Care: Sensory-Adapted Dentistry to Improve Treatment Tolerance in Neurodiverse Young Adults with Autism Spectrum Disorder Kimberlyn Ledesma, Anngella Orraiz Orraiz University of Pennsylvania School of Dental Medicine

RD-92 Therapeutic Potential of Optimized GMSC-derived Secretomes on Temporomandibular Joint Osteoarthritis Annabel S. Liao1, Uddhab Karki2, Shihong Shi2, Qunzhou Zhang2 Ahn D. Le2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

2

RD-93 Evaluation of CYP2C9 Polymorphisms as Predictors of NSAID Response After Third Molar Extractions Sydney Liu1 Katherine N. Theken2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

RESEARCH DAY 2026 21

STUDENT POSTERS RD-94

RD-98

RD-101

Bonding Performance of a Universal Adhesive Resin Cementation System on Zirconia, Lithium Disilicate Glass-Ceramic, Enamel, and Dentin Surfaces

The Interplay Between Neutrophils and Mid-Palatal Suture Mesenchymal Stem Cells (MSCs)

Variability in Occlusal Force Distribution During Instructed Biting Tasks

Allison Liu , Asha Sunkara , Adam Kadan Fusun Ozer1, Markus B. Blatz1,2 1

1

1

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

RD-95 Factors Influencing Access to Dental Care and Maintenance of Oral Health Dylan N. Ohayon1, Joonhyeog Park2, Jaelyn Liu2, Xinyue Li2, Jinbo Niu2,3 Katherine A. France3,4, Tamara J. Cadet2,3 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Social Policy and Practice, 3University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 4University of Pennsylvania School of Dental Medicine, Care Center for Persons with Disabilities 1

2

RD-96 Direct vs. Indirect Veneers on Demineralized Enamel: Material Selection, Adhesive Predictability, and Ethical Boundaries After Orthodontic Treatment.

A Clinical Case Anngella Orraiz Orraiz University of Pennsylvania School of Dental Medicine

RD-97 Clinical Performance of Two Fluoride Releasing Resin Materials in Class I Posterior Restorations After 12 Years Brittnie Pang1, Markus B. Blatz2,3, Oksana Yakymiv1 Fusun Ozer2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

2

22 PENN DENTAL MEDICINE

Ghazaal Parastooei Wenjing Yu3

1,2

Taylor Rutigliano1, Artie P. Nayak1, Amy M. Wong1, Stephanie L. Canington2, Geelsu Hwang3,4,5 Myra F. Laird2,5 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences, 3 University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 4 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry, 5University of Pennsylvania School of Dental Medicine, Center for Clinical and Translational Research

1

1

2

2

University of Pennsylvania School of Dental Medicine, University of Maryland School of Dentistry, Department of Neural and Pain Sciences, 3University of Pennsylvania School of Dental Medicine, Department of Orthodontics

RD-99 Cell Origins and Key Molecular Regulators of the Craniobase Skeletal Development Christy Qian1 Chenshuang Li2, Chider Chen3 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Orthodontics, 3University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology 1

2

RD-100 Population-Level Harms of Systemic Oral Antibiotic use in the U.S. Dental Care Settings: Preliminary Findings of a Systematic Review Andrian Radaios1, Matthias Wallach Weinstein, DDS2, Carla Massignan, DDS, MSc, PhD3 Francisca Verdugo-Paiva, DDS, MSc4, Alonso Carrasco-Labra, DDS, MSc, PhD4 University of Pennsylvania School of Dental Medicine, 2Universidad del Desarrollo, Santiago, Chile, Departamento de Morfología, Facultad de Medicina, 3 University of Illinois Chicago College of Dentistry, Chicago, IL, Clinical Associate Professor, Department of Pediatric Dentistry, 4University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health 1

RD-102 Comparative Effects of Conventional and High-Speed Sintering on the Translucency of Compositional Gradient Multilayer Zirconia Spencer J. Sattazahn1,2, Longfei He1,3,4 Yu Zhang1,5 University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery, 3Stomatological Hospital of Weifang People’s Hospital, Department of Pediatric Dentistry, 4Children’s Hospital of Philadelphia, Craniofacial Orthodontics, 5University of Pennsylvania School of Dental Medicine, Department of Basic and Translational Sciences 1

RD-103 The Influence of Framework Material on Fit Accuracy of Complete Arch Implant Supported Prostheses Fabricated with Different Digital Impression Techniques Emma S. Savitsky1, Sebastian Ollinger2 Markus B. Blatz2,3 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 3 University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

2

STUDENT POSTERS RD-104

RD-107

RD-110

Gene-Specific Dental and Oral Manifestations of Epidermolysis Bullosa

Fisetin Targets Senescence Pathways to Suppress Periodontal Inflammaging

Modeling Pulpitis Inflammation via TNF-α Activation of Peripheral Blood Monocytes

Natalie Shah1,2, David Shon3, Marissa Perman4, Hannah Mumber4, Elizabeth Bhoj5 Kei Katsura1,6

Samuel F. Suslavich1, Jenna M. Fattore2, Xia-Juan Xia1, S M Ziauddin3, Megi G. Hysa1,4,5 S Esra S. Sahingur1

Suyoung Yun1, Kexin Zhang2, Yuchen Jiang1,2, Kyle H. Vining2,3,4,5

Children’s Hospital of Philadelphia, Department of Pediatrics, 2University of Pennsylvania School of Dental Medicine, Department of Clinical Pediatric Dentistry, 3 University of Pennsylvania School of Arts and Sciences, Department of Biology, 4University of Pennsylvania Perelman School of Medicine, Department of Dermatology, 5Children’s Hospital of Philadelphia, Division of Human Genetics, 6University of California, San Francisco

1

1

University of Pennsylvania School of Dental Medicine, Department of Periodontics, 2University of Tampa, 3 Adams School of Dentistry, University of North Carolina at Chapel Hill, Department of Periodontology, Endodontics, and Dental Hygiene, 4University of Pennsylvania School of Arts and Sciences, Department of Biology, 5University of Pennsylvania

University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 4University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 5University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

2

RD-108 RD-105 Preoperative Airway Assessment in Orthognathic Surgery: Implications for Orthodontics Jasmine Shokri1,2, Matthew Halpert1,2, John Button2,3, Amanda Mavricos2 Brian P. Ford2,4,5 University of Pennsylvania School of Dental Medicine, Department of Oral Medicine, 2University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology, 3 University of Pennsylvania School of Dental Medicine, Center for Integrative Global Oral Health, 4Philadelphia VA Medical Center, 5Children’s Hospital of Philadelphia, Division of Plastic and Reconstructive Surgery 1

RD-106 Matrix Stiffness Regulates the Morphology of Dental Pulp Stem Cells and their Immunomodulatory Functions Heewon (Karen) Sohn1, Myung Jin (Jina) Lee1, Yu-Chang J. Chen2,3 Kyle H. Vining1,2,4

A Digital Twin of the Extraction Socket: Predicting Patient-Specific Alveolar Ridge Resorption William C. Tsai1, Akshaya N. Bhati2,3, Dayoon Chang4 Yu-Cheng Chang5, Rahul Mangharam2 University of Pennsylvania School of Dental Medicine, University of Pennsylvania School of Engineering and Applied Science, Department of Electrical and Systems Engineering, 3University of Pennsylvania School of Veterinary Medicine, 4University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 5University of Pennsylvania School of Dental Medicine, Department of Periodontics 1

2

RD-109 Association between PTGS1 Polymorphisms and Opioid Use After Third Molar Extraction Marvin Min Tun Katherine N. Theken University of Pennsylvania School of Dental Medicine, Department of Oral & Maxillofacial Surgery / Pharmacology

University of Pennsylvania School of Dental Medicine, Department of Preventive and Restorative Sciences, 2 University of Pennsylvania School of Engineering and Applied Science, Department of Materials Science and Engineering, 3University of Pennsylvania School of Engineering and Applied Science, Department of Bioengineering, 4University of Pennsylvania School of Dental Medicine, Center for Innovation & Precision Dentistry 1

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