PHLBI Annual Report 2017

ANNUAL REPORT

2017

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2017 ANNUAL REPORT

2017 ANNUAL REPORT

Lung & Blood t r a He innovative ideas i Inst c itu nto ifi evelop effe c te cti ve Pa idly d enerate hope through Vi sio n:

OUR TEAM

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OUR EVENTS

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FINANCIALS

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OUR SPONSORS

“Dr. Cameron gave me hope when there was none.

Because of him, and his incredible experience and skills as a surgeon, I am here four years later and able to give this review. Thank you Dr. Cameron for the many years that you have put into helping others with Mesothelioma. It paid off for me. So you can imagine how easy it was for me to donate my tissue and specimen to the Pacific Mesothelioma’s International Tissue Bank for this research. I pray that one day soon, he will find a cure for this dreadful disease. I encourage everyone to become a Research Associate , just like me, by donating your specimen/tissue to this research program. It is so easy and you can help make a difference” ~ Kathy

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Increase Stakeholder Satisfaction & Engagement

Our dedication Our people are and integrity empowered, improves the skilled and way we work effective Our Culture is high performing and innovative n u

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Excellence in Research

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SURVIVOR STORIES

Deliver excellent research

Support through patient & family outreach

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Expand Patient & Family Outreach

education on treatment options

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WHO WE ARE

ell Governed Be W

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Expand Resources For Sustainable Funding

inancially Stron Be F g

THANK YOU

th : G pport & education rese e n u a o s i rch s s i , M takeholder S & F oc nt us tie a Provide P

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CONTENTS

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Be Responsible Stewards Of The Funds Received

a tio n w We o pu ed w t q g We ua hin d per lity at the heart of evert ro u p f o e W e m We rm research of which we’r ers ities ak v a l ue oth un ea our relationships with omm m ea c our surabl e difference to

Our Values

In the spring of 2017, the Board of Directors convened for a two-day retreat, with the purpose of refining PHLBI’s strategy.

PHLBI will continue to deliver excellence in research, provide education

and support through our outreach programs, and be good stewards of the funds we receive.

Our vision mission, strategic aims and values are listed in this diagram.

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OUR TEAM

WHO WE ARE

SURVIVOR STORIES

OUR EVENTS

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What a sterling year we had! We received a million-dollar grant, hired two new scientists, expanded our lab, purchased new equipment, exceeded our budget, and had some wonderful events, to name a few accomplishments.

The Pacific Heart, Lung & Blood Institute (PHLBI) focuses on orphan diseases of the heart, lung and blood that receive little attention and funding. One of the divisions of PHLBI, The Pacific Mesothelioma Center (PMC), is currently developing cancer therapies using mesenchymal stem cells (MSCs) derived from placenta and bone marrow. These cells are modified to express large amounts of Interleukin 12, which stimulates the immune system to reject cancer cells. In 2017 we filed a patent for our MSC project, and we are excited to see where this takes us.

A generous anonymous million-dollar grant enabled the appointment of two world-class research scientists, Dr. Masahide Tone and Dr. Yukiko Tone. Masahide Tone received his PhD at Tohoku University in Japan. His wife Yukiko Tone received her DSc at Tokyo Metropolitan University in Japan. Both scientists have worked at the universities of Cambridge and Oxford in the UK, and the University of Pennsylvania and Cedars Sinai Medical Center in Los Angeles. They are now collaborating with our Scientific Advisor, Dr. Robert B. Cameron, MD, FACS, who is Professor of Cardiothoracic Surgery, Surgical Oncology at UCLA, Director of the UCLA Mesothelioma Comprehensive Research Program at the David Geffen School of Medicine at UCLA, and Chief of Thoracic Surgery at the West Los Angeles Veterans’ Administration.

A project for the clinical trial of IL-4-immuno-toxin (IL-4R) mesothelioma therapy, primarily developed by the Cameron team, has found that mesothelioma expresses IL-4R at high levels, and a recent study also suggests that IL-4R expression levels in mesothelioma are significant to survival rates.

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A strength in our institute is that the clinical and research teams are directly connected, allowing us access to patient specimens for our tissue bank, which is the best environment in which to develop cancer immunotherapy strategies. This positions us favorably over other research institutions for research breakthroughs.

Establishing new therapeutic strategies is our highest priority.

We are also proud to continue supporting our International Symposiums on Malignant Pleural Mesothelioma. The symposiums give unrivaled opportunities both to the medically savvy and to the general public, including mesothelioma patients, to not only learn first-hand about groundbreaking discoveries, but also to exchange ideas.

The symposiums are held on the last Saturday of the month each year in September.

Our hard-working board of directors convened in the spring of 2017 to create a new strategic plan which will guide us in expanding our unique capabilities while ensuring continued financial sustainability and strong governance. A special thanks this year to PHLBI’s fabulous executive director, Clare Cameron. Clare’s dedication and fundraising acumen continues to make PHLBI hugely successful, as we transform PHLBI into a cutting edge-non-profit medical research institution.

Our board also welcomed new members: Kellie Sutherland as Board Secretary; and Joseph Garland and Michael Arlen as Directors. Our new members bring diverse professional skill sets to us and extensive experience in executive leadership.

I am so encouraged by their generosity, creativity and giving spirit.

Lastly, perhaps you are aware that PHLBI provides early career training and mentorship in medical research to undergraduate student interns from UCLA and LMU. At PHLBI, our interns have the unique opportunity to gain real-world experience and fill meaningful roles in medical research at a young age. In return, PHLBI’s core mission of conducting cancer immunotherapy research benefits from their involvement.

Please join me in doing everything that we can to help our wonderful organization. Everyone is doing great work and is truly deserving.

Our door will always be open when you visit and thank you always for keeping us in your mind and in your hearts.

With gratitude,

Rhonda Ozanian Board Chair

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THANK YOU

OUR TEAM

BOARD OF DIRECTORS

SCIENTIFIC ADVISORY BOARD

Rhonda Ozanian, PhD – Board Chair

HEART

VA West Los Angeles Medical Center

Peyman Benharash, M.D. UCLA

Robert M. Strieter, M.D., FCCP, MACP Global Translational Medicine Head for Respiratory, Novartis Institutes for BioMedical Research, Inc.

LUNG

Anne S. Tsao, M.D. Associate Professor, Director, Mesothelioma Program Director, Thoracic Chemo-Radiation Program University of Texas M.D. Anderson Cancer Center

National Association of Corporate Directors (NACD) Governance Fellow Retired Lieutenant Colonel - Department of Defense

Alexa McCulloch – Treasurer

President, Harvard Business School Association of Southern California

Kellie Sutherland – Secretary

WHO WE ARE

Engineer, Northrop Grumman

Michael Arlen – Director

Entrepreneur

Douglas Gamble – Director

SURVIVOR STORIES

International Vice President of the Western States Conference Heat and Frost Insulators and Allied Workers International Union (formerly the Asbestos Workers Union)

Warren S. Grundfest, MD, FACS – Director Professor of Bioengineering, UCLA

Joseph Garland – Director

Managing Partner and CEO at Centennial Harvest Group

Brent Keeton – Director

OUR EVENTS

Co- Founder, Chairman and Chief Investment Officer, Grange Capital

Radha Savitala – Director

Deputy General Counsel Prime Healthcare Services

PHLBI STAFF FINANCIALS

OUR SPONSORS

Dr. Robert B. Cameron, M.D. Scientific Advisor Clare Cameron Executive Director

Lien Hua-Feng, RN, MSN, FNP-C Nurse Practitioner

Masahide Tone, Ph.D., Research Scientist

Christina McSherry Marketing & PR

Yukiko Tone, Ph.D., Research Scientist

Victoria Adams Consultant

Our staff functions in multiple capacities to maximize the use of our human and fiscal resources for administration, research and consumer health education.

Robert B. Cameron, M.D. Cardiothoracic Surgery and Surgical Oncology Professor, David Geffen School of Medicine at UCLA Director, Comprehensive Mesothelioma Program & Chief of Thoracic Surgery, VA West Los Angeles Medical Center Diana Gage, M.D., Ph.D. Director, Stereotactic Radiosurgery Program Director, Radiation Oncology Wellness Program Department of Radiation Oncology, VA Greater Los Angeles Health Care System Dr. Warren S. Grundfest – Director Professor of Bioengineering, Electrical Engineering and Surgery at UCLA Senior West Coast Clinical Advisor and Portfolio Manager for Nanomedicine and Biomaterials for TATRC (the Telemedicine and Advanced Technology Research Center of the U.S. Army) Dr. Jim teWaterNaude MBChB, MPhil (MCH), FCPHM Cape Town, South Africa Sherven Sharma, Ph.D. David Geffen School of Medicine at UCLA and

Olga M. Olevsky, M.D. Assistant Clinical Professor, David Geffen School of Medicine at UCLA

BLOOD Gary L. Schiller, M.D. Professor of Medicine, David Geffen School of Medicine at UCLA

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OUR TEAM

WHO WE ARE

WHO WE ARE ABOUT US Established in 2002, the Pacific Heart, Lung & Blood Institute (PHLBI) is a 501 (c) (3) non-profit, research institution that is committed to advancing medical research that may lead to new treatments, early detection and prevention programs for chronic disorders— including diseases of the heart, lung and blood.

Modeled on the National Heart, Lung & Blood Institutes of the NIH, PHLBI is divided into divisions and centers:

SURVIVOR STORIES

• Pacific Heart • Pacific Lung • Pacific Mesothelioma Center • Pacific Thymus Center • Pacific Blood

OUR EVENTS

One of the divisions of the PHLBI is the Pacific Mesothelioma Center (PMC) whose focus is on finding better treatments for malignant pleural mesothelioma (MPM), an asbestos-related cancer affecting the lining of the chest - the pleura.

PHLBI’S MISSION Generate hope through research, support and education.

FINANCIALS

PHLBI’S VISION Rapidly develop innovative ideas into effective treatments.

INSERT QUOTE FROM GUIDESTAR OUR SPONSORS

PA C I F I C H E A R T

PA C I F I C L U N G Pacific Mesothelioma Center • Pacific Thymus Center •

DIFFERENTIATORS What makes the Pacific Mesothelioma Center (PMC) at The Pacific Heart Lung & Blood Institute (PHLBI) different?

PA C I F I C B L O O D

reviews from the people that we serve, our volunteers and our donors. www.toprated.greatnonprofits.org/

• PHLBI is the only non-profit research institute that deals with cancers of the chest and that does in-house research (intramural).

• We have our own in-house labs – The Punch lab at UCLA and a newer lab on Santa Monica • We have our own scientists • We have coordinated research • We have an in-house research portfolio • We are associated with a major university - UCLA

GREAT NONPROFITS TOP-RATED AWARDS In 2017, PHLBI was recognized with the prestigious Great Nonprofits Top-Rated Award, a “people’s choice” award that is earned based on

GUIDESTAR EXCHANGE GOLD LEVEL In order to earn GuideStar’s Gold level designation, PHLBI provides additional transparency to financial statements and operational details. The PHLBI believes that sharing governance, leadership and financial impact information is vital for donors to understand and support our mission. www.guidestar.org

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RESEARCHER SPOTLIGHT

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Dr. Robert B. Cameron, MD FACS, is one of the leading experts in North America on the treatment of pleural mesothelioma.

He has been treating mesothelioma patients for over 20 years and is an early innovator of the lung-sparing pleurectomy with decortication (P/D) surgical procedure for mesothelioma. He has authored or co-authored over 40 papers on oncology, thoracic surgery and other topics.

Dr. Cameron attended medical school at UCLA, where he obtained his medical degree. He completed three years of training as a clinical associate in surgical oncology at the National Cancer Institute of the National Institutes of Health in Bethesda, Maryland, a five-year residency in general surgery at UCLA, and a two-year fellowship in cardiothoracic surgery at Cornell-New York Hospital and Memorial Sloan-Kettering Cancer Center in New York City.

RESEARCHER SPOTLIGHT Dr. Masahide Tone has led research groups in molecular biology, immunology, immunotherapy, and cancer immunology at Hoechst (Japan), the Universities of Cambridge and Oxford (UK), the University of Pennsylvania, and Cedars Sinai Medical Center. His vast area of research expertise is in molecular and cellular immunology, CRISPR gene editing, gene regulation, antibody engineering, cytokines, macrophages, dendritic cells, T-cells and regulatory T-cells (Treg). In addition to his work as a researcher, Masahide has served as an associate editor for the Journal of Immunology and a review editor for Frontiers in Immunological Tolerance.

Throughout his research career he has mentored many post-doctoral fellows, graduate and undergraduate students. His most recent work at Cedars Sinai Medical Center centered around the study of development and function of Treg to develop cancer immunotherapy, and drug resistance induced by differential gene expression in tumor environments. Masahide will bring his immense knowledge, vast skills, and leadership capabilities to the PMC lab as Senior Researcher and Director of Research.

RESEARCHER SPOTLIGHT

OUR SPONSORS

Doctor Yukiko Tone is a molecular biologist whose skill set includes gene cloning, DNA/RNA/protein analysis, antibody engineering, BAC (Bacterial Artificial Chromosome) technology and CRISPR gene editing. After finishing her academic studies, Yukiko moved to Great Britain where she studied molecular mechanisms of

the thyroid hormone receptor at the University of Cambridge. She then moved on to the University of Oxford where she worked on regulation of gene expression of cytokines (IL-12, IL-18 and IL-10) and TNF/TNFR superfamilies (CD40, OX40 and GITR, GITR ligand). Later she worked at the University of Pennsylvania where she studied regulatory T-cell (Treg) mediated immune responses. After moving to Los Angeles, she worked as a project scientist where she continued her work studying Foxp3 gene expression in Treg. She recently focused on gene regulation in cancer cells to overcome drug resistance and to reduce cancer cell survivability in tumor microenvironments. Her diverse research background and enormous dedication to her work make her an asset as a Senior Researcher on the PHLBI team.

RESEARCHER SPOTLIGHT Nurse Practitioner Lien HuaFeng embodies PHLBI’s commitment to patient care and treatment in her work. Through our partnership with the Department of Veterans Affairs, Nurse Lien meets with veterans and their families to discuss clinical care options and treatment modalities. She is a vital resource to thousands of people, from all walks of life and all parts of the country, answering questions on available treatment and support. Because mesothelioma is rare, there are very few experienced medical staff like Nurse Lien, and patient care resources are limited. PHLBI is working to expand our dedicated staff but we cannot do this without more sources of funding. Hiring experienced and dedicated nurses like Nurse Lien is something we are working towards!

CURRENT RESEARCH Our primary focus at PHLBI is centered on developing Immunotherapy strategies using Mesenchymal Stem Cells (MSC) against cancers, particularly the aggressive form of Mesothelioma. To date, we have amassed significant baseline data that will power our current efforts. Even though the data is not published yet, we are actually well positioned for a successful 2018 based on our new research team. Our new team has assessed our accomplishments and performance in 2017, and have taken steps to better position our institute.

A strength in our institute is that the clinical (headed by Dr. Robert B., Cameron) and research teams are directly connected, and this allows us for faster innovation and patient participation.

This is the best environment to develop cancer Immunotherapy strategies. Our access to patient specimens is an additional advantage. We add on average two tumor samples a week for our research, thereby increasing the robustness of our tissue bank. Our abundant access to Mesothelioma samples (40 in our tissue bank), even though Mesothelioma is a rare aggressive cancer, positions us favorably for research breakthroughs.

Our new research team started at the end of August 2017. They have since reorganized the research operation by upgrading the laboratory and acquiring new and necessary equipment in order to perform world class molecular immunology research. A highlight of their efforts is their recent acquisition of FACS and qPCR platforms. They have already discovered several new findings and are working on publishing these. The new team is actively pursuing three projects (the “Aims” described here), centered on the development of cancer immunotherapy using mesenchymal stem cells.

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AIM 1: Developing cancer immunotherapy strategies using tumor-homing mesenchymal stem cells (MSC). The goal of Aim1 is generating the anti-tumor cytokine expressing MSC for cancer immunotherapy (Fig. 1B). We will generate several potential cytokine expressing MSCs (potential cytokines: IL-2, IFN-γ, IL-12, and IL-15) and, in three years, we will examine and select which cytokine expressing MSC can effectively activate anti-tumor immune cells. These data will be published to contribute to developing all MSC-mediated immunotherapy strategies. In the fourth year, we will work to develop clinical trial strategies based on the findings. To this end, we must consider safety issues of the modified MSC, compared to other stem cell and immunotherapy developments.

AIM2: Investigating MSC properties to develop cancer immunotherapy strategies. The goal of Aim 2 is generating the best MSCs for cancer immunotherapy.

However, these stem cells also express some immune-suppressive molecules that might inhibit cancer therapy. We will therefore analyze gene expression in MSCs, and based on the data, we will modify the MSC that is suitable for cancer therapy. The obtained data is critical for developing immunotherapy strategies. We believe that we can select and/or generate the best MSCs for the Immunotherapy strategy in the next three years. These data are important not only for developing our strategies but also for developing all other MSC-mediated immunotherapy strategies. Therefore, we will publish the data for developing all MSC-mediated immunotherapy strategies. In the last year, we will generate anti-tumor cytokine expressing MSC (as described in Aim 1) using the best MSCs generated using the strategy proposed in this Aim. The cytokine expressing MSCs generated using plans described in Aim 1 and Aim 2 will be used for clinical trial.

AIM 3: characterizing mesothelioma to develop diagnosis and targeting immunotherapy strategies. Mesothelioma is an aggressive cancer with few treatment options and low survival rate. Establishing therapeutic strategies against this cancer is urgently required, and therefore, we selected this cancer as the first target of our developing immunotherapy (described in Aim 1). In Aim 3, we also plan experiments to identify bio-markers on mesothelioma cells. By identifying bio-markers, we can also develop new mesothelioma immunotherapy strategies. Previously, the Cameron team identified IL-4R as expressed on mesothelioma cells at high levels and developing the IL-4-immuno-toxin mesothelioma therapy strategy. To reach the clinical trial stage, we will further analyze IL-4R expression using mesothelioma samples from our international tissue bank.

Normally, our immune systems have the ability to remove abnormal cells, including cancer cells. However, some cancer cells cunningly escape from the immune-system by producing immuno-suppressive regulatory proteins (e.g. PD-L1, CTLA4, TGF-β, IL-10, and HLA-G). Indeed, many immune cells are disabled around the tumor sites (Fig. 1A). To solve this problem, we will re-activate immune

cells using anti-tumor regulatory proteins (e.g. anti-tumor cytokines) delivered by MSC (Aim1).

Since MSCs gather to the tumor sites with their tumor-homing properties, we can deliver anti-tumor cytokines to the cancer site by generating the cytokine expressing MSC (Fig. 1B).

INTERNATIONAL TISSUE BANK The PHLBI received Institutional Review Board (IRB) approval in 2016 for its international tissue bank.

Diseases of the heart, lung and blood affect a large number of people in the U.S. and throughout the world each year. It is imperative that both personal health information and tissue samples are collected from as many patients as possible in order to understand: • The normal tissue biology • The natural history of the disease • Outcomes from current treatments

• The advantages and disadvantages of • potential future novel therapies PHLBI is soliciting tissue specimens and seeks study participants who wish to donate their tissue and personal health information for current and future research at the institute.

If you’d like to assist PHLBI by donating urine or blood, please call our offices at 310.478.4678 to set up an appointment, or ask your doctor to take a sample that can be shipped overnight to us.

STUDENT INTERNSHIP PHLBI provides undergraduate student interns from nearby colleges, UCLA and Loyola Marymount University, early career training and mentorship in medical research. Our interns are given hands-on educational opportunities that are difficult to obtain at their host universities as undergraduate students. University research labs are often constrained by limited budgets, where

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The experience of working in a lab with research scientists may help them realize what they may want to do with their careers, whether it is in the sciences, a surgeon, a doctor, a physician’s assistant, or nursing, their experience will teach them how to hone leadership and teamwork skills as they collaborate with others. And most importantly, the research process assists students in developing skills which they will use throughout their lives. Participating in research teaches students how to communicate with their ideas and how to analyze and critique the work of others.

OUR TEAM

WHO WE ARE

INTERN SPOTLIGHTS

SURVIVOR STORIES

OUR EVENTS

FINANCIALS

resources are typically prioritized for post-doctoral fellows and graduate students pursuing advanced degrees. At PHLBI, our interns have the unique opportunity to gain real-world experience and fill meaningful roles in medical research at a young age. In return, PHLBI’s core mission of conducting cancer immunotherapy research benefits from their involvement.

The new student will initially be trained by our research scientists. Once the new student becomes familiar with lab protocols, he/she will operate with minimal supervision. The successful students will have a natural ability to concentrate on meticulous hands-on tasks for extended periods.

The students are given individual projects and also help us with our tissue bank.

The tissue bank was set up in 2015, with the purpose of collecting health information and tissue samples from participants who wish to donate their tissue for future research at The Pacific Heart, Lung & Blood Institute.

OUR SPONSORS

Both normal and diseased tissue samples are collected and placed into database, maintained at PHLBI. Their job is to assist with the handling and processing of human tissue, blood and urine specimens collected from cancer patients undergoing treatment at UCLA.

“By working in the lab with live tissue obtained from patients’ surgeries, I have come to understand how closely research and clinical treatments are linked. The findings obtained from an experiment in the lab. can directly provide knowledge required for the development of clinical treatments, which is incredibly exciting. I find fulfillment in knowing that my daily work with cell cultures could contribute not only to the general body of scientific knowledge, but also someday to improving patient’s lives”. ~ Tonya “As an intern at Pacific Heart, Lung & Blood Institute, I have learned how to apply my textbook knowledge to real experiments. Under the guidance of Dr. Cameron, I am able to design, conduct, and analyze experiments that track cell growth and viability with the addition of different interleukins. I am very thankful to be able to participate in research that can potentially help so many patients and their family. As an intern, I have learned so much about the mechanism of mesothelioma cells, which inspires me to learn more about the mechanism of other diseases throughout my future career”. ~ Minh

“Working at PHLBI was my first exposure to research and has pushed me to pursue a career in academic medicine. From processing tissue specimen, to growing and modifying mesenchymal stem cell lines, to conducting clinical research, I’ve been able to see the small, incremental steps necessary for answering a research question and have grown to appreciate what it takes to advance medicine by actually getting to do it. PHLBI has given me a glimpse into the challenges and rewards of advocating for patients at every step in the process of their care” ~ Blair

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OUR TEAM

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OUR EVENTS

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David Theobold

A 10 YEAR SURVIVOR OF MESOTHELIOMA

In late 2007 David had really bad pains in his chest. Saint Jude Medical Center in Fullerton thought he was having a heart attack, but after a stress test, EKG and more, they said “No, you’re fine.” A couple of days later, at his son’s school band concert, the pain was so bad he could not breathe. After various doctor visits without a diagnosis, he finally had a CT scan and that’s when his GP said, “Have you been around asbestos?” “No,” David replied, “and I had no idea what he was implying, none whatsoever.” In the new year they did a biopsy and referred him to City of Hope hospital. There, Dr. Kemp Kernstine performed another biopsy and the diagnosis of pleural malignant mesothelioma (“meso”) was confirmed. It had taken about 3 months to get an answer. David’s treatment started with debulking, which is surgical removal of as much of the tumor as possible, performed by Dr. Kernstine.

Today, ten years later, David says the greatest challenge at that time was not the meso, but that he had to sort through and understand his treatment choices. It was a help when Dr. Kernstine referred him to a consultation with Dr. Robert B. Cameron at UCLA, one of the leading experts in North America on the treatment of pleural mesothelioma.

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David felt fine. He took up cycling, including participating in several of the Lance Armstrong cycling events for raising cancer awareness. “There was no rhyme or reason why the meso stopped. I put this down to the treatment and also, maybe, to my attitude of being positive and active.”

He also never paused in his profession as a machinist in manufacturing aerospace defense, even during chemo. Some days he’d go home early or go in late, “but I went to work every day. We are a small company so I don’t sit behind a desk. I’m out in the shop with sleeves rolled up, whatever it takes.”

WHO WE ARE

SURVIVOR STORIES

frequency of scanning was dropped to just a yearly CT scan. “Fortunately, it worked. I got 10 years out of it!”

He then did eight cycles of chemo. “I felt pretty rough but I never ever thought that it was going to beat me. I wanted to see my boy through high school and graduate from high school and I set that as a goal.” After four or five years his

To this day David has never figured out exactly where and when he was exposed to asbestos. “Back in the early 70s when I was a kid in England, it was everywhere. When I was 5 or 6 years old they were knocking down some old prefabs and the roofing was corrugated sheets of asbestos. We kids were playing around on the demolition site and we were putting these sheets of asbestos over a little fire. Then we rode our bikes and did the Evel Knievel thing over the fire. Things were breaking and going up in the air. That is probably the worst thing you could ever do! But who knows? Who really knows?”

And then at Christmas last year, he felt something in his back and shoulder. Upon having his annual scan at Saint Jude’s in March, the CT scan showed some new growth. A PET scan and biopsy confirmed that the cancer was back in the same area in his left lung as ten years ago. David thought he’d have debulking again, but this time was told that it was inoperable. “I was pretty much devastated.”

But then Dr. Cameron scheduled David for a new procedure at UCLA, called cryoablation. The radiologist, Dr. Fereidoun Abtin, inserted a hollow needle while David was in a CT scan, so they could see the cancer. Cryoablation freezes and kills mesothelioma cells. “You can see the cancer cells and they change color,” reported David.

Dr. Cameron also offered the opinion that it wasn’t going to be effective for David to have any more chemo sessions, because he’d already had it 10 years ago. Instead, as a patient of Dr. Cameron, David will undergo immunotherapy, which will trigger his white blood cells to attack the cancer cells. Next steps will depend on the efficacy of that and the cryoablation.

As David puts it, “It’s a mindset. If you’re a positive person you put positive people in your corner and have positive thoughts. Yes, you can have bad days, and it’s 10 years later and I am fighting the same battle. It’s very easy to lay on a couch and feel very sorry for yourself, but then the couch is winning.

I get up every morning and thank the big man for another day and I get on with it.” Overall, David’s advice is to “go to work, stay positive, and lead a normal life.”

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OUR TEAM

“Once in a while you run across a virtuoso in the medical field who is all about quality of life and not simply enamored with capital and a surgery job. Dr. Robert Cameron has become the expert in mesothelioma (in hospitals and for the legal biz) and was kind enough to find creative solutions to my very large fibrous tumor that was pressing on my lung and heart and attached to my diaphragm. Other chest surgeons that I went to wanted to remove the tumor and possibly the lung.

Dr. Cameron saved my lung and my life and I continue to enjoy a quality of life because of him. I will continue to help Dr. Cameron and his Executive Director, Clare Cameron in every way possible. If you have mesothelioma and want the latest and greatest....Dr. Cameron is your solution without a doubt. He is kind, sensitive, intellectual, and a superb surgeon. Everyone should support the Pacific Heart, Lung, and Blood Institute and their research”. ~Larry Wilcox

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Cindi Hausheer Cindi Hausheer has myasthenia gravis, myositis and Hashimoto’s disease. “Just a few autoimmune diseases,” she says, almost casually. She also has Type 2 diabetes and is a lung cancer survivor.

Cindi retired from teaching in 2013. She not only taught every grade from kindergarten to eighth, she was very involved with math workshops that promoted “girls understanding and enjoying math.” She has had a lot of other interests too, such as glass fusion, making bowls, menorahs, and jewelry. “Visualize a piece of glass, then putting other pieces of glass on top and melting it in a kiln.” She also had a business making and drying pasta, and another making small heat compresses.

It was purely “by luck” that she started seeing Dr. Robert Cameron in 2005. At the time she could hardly swallow, and she’d already seen many doctors. She had also suffered through pneumonia. When her son underwent some chest surgery that year, she asked her son’s doctor to recommend someone for her issues. That was Dr. Cameron. That year he performed a thymectomy (surgical removal of the thymus gland), giving her immediate relief for the pain in swallowing. The thymus was found to be cancerous, so she had 6 weeks of radiation, a fatiguing time accompanied by weight loss.

In 2010 she was diagnosed with myasthenia gravis. “You can feel very weak and it’s hard to walk. I also have weakness with my hands.”

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Her lung cancer was found by Dr. Cameron while he was looking at her lungs with a CT scan (computed tomography, a combination of X-rays and a computer). In 2012, Dr. Cameron performed an 8-hour lung operation. Every six months

2017 ANNUAL REPORT

since, overseen by Dr. Cameron, she continues to have CT scans. These days she is at a steady state with her conditions, aided by medications, but she still deals with fatigue and weakness. She “pushes through.” Fortunately, her myositis is in remission. And she hasn’t found Type 2 diabetes to be a burden. She takes metformin (a glucose lowering drug) and watches what she eats.

With all that, she has her strategies to keep busy.

Her two sons and a daughter live and work locally, so are able to visit and lend support to her and her husband, a soccer referee and coach, who is currently recovering from some surgeries.

She enjoys yoga and is taking a philosophy class.

How else does she cope? “My friends, I can talk to them. Going to classes and just keeping my mind on other things. It’s too easy to stay isolated in your house.”

CARE GIVER SUPPORT GROUP This marks the second year since PMC began offering monthly caregiver support group meetings.

The support group led by PMC Nurse Practitioner Lien Hua-Feng and coordinated by Christina McSherry was created to give caregivers of mesothelioma patients an outlet to ask questions, share stories, and release difficult emotions. The group helps caregivers connect with other caregivers who can directly relate to their experiences.

Cindi gives high praise to everybody at PHLBI, as always friendly and helpful, and has nothing but superlatives for Dr. Cameron. “He is an incredible, incredible doctor and person. He saved my life twice and I love him for that. He’s extremely kind and the best.”

VOLUNTEER SPOTLIGHT One thing Robin Olin has always strived to do is to help others in whatever way she can. After moving to the US from Montreal, Quebec she has worked as an advocate in a number of nonprofit settings including animal welfare, homelessness, and human empowerment.

Her current position as a cold cap therapist involves working with cancer patients to preserve their hair while undergoing chemotherapy, something she finds truly rewarding after her own battle with breast cancer. Robin started volunteering with PHLBI in 2014. Robin’s roles have included serving on committees for PHLBI events, assisting with multiple events, and going door to door fundraising for the organization’s 5K Walk for Mesothelioma. Robin’s dedication, tenacity, and willingness to help PHLBI further showcases how our greatest assets are our volunteers.

21 2017 ANNUAL REPORT

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OUR TEAM

OUR EVENTS

WHO WE ARE

SURVIVOR STORIES

OUR EVENTS THE GREATEST ESCAPE MOTORCYCLE RIDE

FINANCIALS

OUR SPONSORS

The 5th annual “The Greatest Escape” Motorcycle Ride presented by asbestos law firm Worthington & Caron P.C. was held on Sunday, June 4th. The ride originated as a tribute to “The Great Escape” movie, starring actor Steve McQueen, who died of mesothelioma. Since its inception, hundreds have gathered each year to honor those who have lost the fight against mesothelioma and to raise money for research. In 2017 we raised $78,640 and 100% of proceeds from the ride will be applied directly to the Punch Worthington Laboratory at UCLA and the Pacific Mesothelioma Center laboratory on Santa Monica Boulevard, to further our important research on mesothelioma.

More than 200 riders, passengers, and attendees enjoyed the scenic ride that kicked off from Top Rocker Harley-Davidson in Canoga Park and also, Antelope Valley Harley Davidson and traveled the breathtaking path through the Angeles

National Forrest, ending at the historic Newcomb’s Ranch on Angeles Crest Highway 2. The event was hosted by Grand Marshall, Fabio and the riders were joined by actress Kristy Swanson, Olympic Gold Medalist Lloyd Eisler, the cast of

the new FX series The Mayans MC, actor Larry Wilcox, and actor/professor Roger McGrath, who knew Steve McQueen personally.

Thank you for your support and we’d love to see everyone again next year.

“We have been to the wonderful fundraisers for mesothelioma, and the Pacific Heart Lung & Blood Institute has developed and nurtured amazing events. Watching the behind-the-scenes staff showed us an incredible team effort and always a success. I can’t say enough about this staff and we have been there to witness it. Personally, I have done events, but this magnitude of these kind of events takes leadership and organizing. The events are a very upscale with a lot of thought and hard work. Everything is done with class. People get involved because of the management who work so hard putting it on. We salute you Pacific Heart Lung & Blood Institute staff and all of your team!” ~ Ovarian Cancer Survivor

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OUR TEAM

2017 ANNUAL REPORT

“Recently I attended the 5K Mesothelioma hike at the Paramount Ranch in Agoura Hills. The setting was beautiful, a set location of a western town with a backdrop of mountains that seemed to protect this magical place of a time gone by. The Pacific Heart Ling & Blood Institute thought of everything that could make the day perfect for all who attended, while at the same time making sure that all of those who lost their battle with mesothelioma were remembered. I found myself walking for those I did not know personally but whom I felt deeply connected to, knowing that each step I took was honoring those who can’t be there and those who are just beginning their fight with this devastating disease. What a great event for such a worthwhile cause.” ~Anonymous

WHO WE ARE

SURVIVOR STORIES “TOGETHER WE WALK AS ONE,” ANNUAL 5K WALK/HIKE FOR MESOTHELIOMA

OUR EVENTS

FINANCIALS

OUR SPONSORS

The 6th annual 5K Walk/Hike for Mesothelioma took place on October 22nd, 2017, at the Paramount Ranch in Agoura Hills. With over 350 walkers, the event raised over $160,000 to find better treatments for malignant pleural mesothelioma. In the words of Master of Ceremonies, CHiPS star Larry Wilcox, “Asbestos is everywhere, and once you inhale it it’s a major problem. It’s important that people get educated about it, and the walk is a great way to increase awareness and funding.”

Presented by Worthington & Caron, P.C, the event brought together thirty-two teams, as well as supporting organizations and individual walkers, who gathered at the park at 9 a.m. Each registrant received a complimentary T-shirt, fruit products generously donated by Dole, and sunscreen, before leaving on the hike.

Afterwards, participants enjoyed a catered lunch by local Agoura Hills favorite Italia Deli. The event also offered David’s Tea, Duverger Macaroons, Monster energy drinks, Mustache Mike’s Italian Ice and a concert by The Six Billion Dollar Band. The live auction featured items such as a photo safari for two in South Africa and a Maui luxury package. The silent auction and drawing featured items such as gift baskets, experiences, dining and adventure certificates,

and weekend getaways.

her fight against mesothelioma.

Some teams took a creative route in raising funds and awareness for the cause, such as a pasta party by “Team Jarvis,” a bake sale at UCLA by “Team Cameron’s Cruisers,” and Powerball at Captain’s Treasure Chest by “Team Ganoe.” The top fundraising team, “Double Nickels,” captained

by Cubby Winkel, raised over $19,000. Cubby Winkel walks to support his wife, Judy Winkel, in

“I’m glad that my team and I were able to participate again in this year’s walk,” walker and mesothelioma survivor Philip Prokop said. “I will continue to support and help in any way that I can.”

For more information on the 5K Walk for Mesothelioma in 2018 visit: www.phlbi.org/5k-walk-for-mesothelioma

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“I have volunteered for a few PHLBI events. Having volunteered for many, many organizations for the past 25 years, I can say that PHLBI is one of the best organizations to volunteer for--there is just so much heart in everything they do!

Unlike those experiences you have when you know you are just a number on a volunteer list, PHLBI really stands out by personalizing their communication with you, making it a point to know your name, and showing sincere appreciation for your contribution that would turn the head of even Dale Carnegie. This is the type of treatment you want as a volunteer--knowing that you aren't just disposable free labor invited out to do the work the employees don't want to do. Nope, with PHLBI, you are invited to help them do the work they are doing right alongside you.

As a volunteer, you are treated just like a donor or sponsor--a relationship is being cultivated with care for the long run. What else can you ask for? To me, that kind of attention is worth far more than a rough cotton T-shirt!” ~ Rebecca

WHO WE ARE

SURVIVOR STORIES

OUR EVENTS

FINANCIALS

OUR SPONSORS

7TH INTERNATIONAL SYMPOSIUM ON MALIGNANT PLEURAL MESOTHELIOMA The 7th International Symposium on Malignant Pleural Mesothelioma was held on Saturday, September 30, at the UCLA Meyer & Renee Luskin Conference Center. The focal point of the symposium was on clinical therapies and research data to prevent, detect and treat malignant pleural mesothelioma. Health care professionals including physicians, nurses, and scientists joined students, mesothelioma patients and their families to attend this informative and educational conference. The Symposium was co-hosted by UCLA and the Pacific Mesothelioma Center (PMC).

The morning session was opened by symposium chair, Dr. Robert B. Cameron, MD, FACS, who discussed The Future of Mesothelioma Surgery. “Although surgery in mesothelioma has decreased due to a perceived lack of efficacy among oncologists and other physicians, there are therapies, such as preoperative radia-

tion, cryoablation and Betadine lavage, which are keeping surgical results ahead of other therapies.” said Dr. Cameron, Professor of Clinical Cardiothoracic Surgery and Surgical Oncology.

The highlights of his presentation centered on how these therapies supplemented standard of care treatments through preoperative, intraoperative, and postoperative therapeutic modalities.

The symposium’s other distinguished faculty included: Anna Nowak, PhD of the University of Western Australia; Luana Calabrò, MD, University Hospital of Sienna, Italy; David S. Schrump, MD, National Cancer Institute, Maryland; Jacques P. Fontaine, MD, Moffitt Cancer Center, Tampa; Brian Cunniff, PhD, University of Vermont; Haining Yang, MD, PhD, University of Hawaii; Arti Shukla, PhD, University of

Vermont ; Olga Olevsky, MD,UCLA Lien HuaFeng NP, UCLA /VA/PHLBI and Clare Cameron, executive director of the PHLBI. “This year has been incredibly hopeful as there are new biological advances, such as immunotherapy, anti-angiogenic therapy and others, that are likely to lead to improved treatments in the future” said Dr. Cameron. Immunotherapy is advancing rapidly and many other therapies, such as thermal, chemical, gene and cell-based therapies are on the horizon”.

The 8th International Symposium will be held once again at the UCLA Meyer & Renee Luskin Conference Center on Saturday, October 29th 2018.

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WHO WE ARE PHLBI HOLIDAY OPEN HOUSE PHLBI hosted its annual holiday open house on December 6th, 2017.

SURVIVOR STORIES AN EXCLUSIVE SHOWING OF ORIGINAL WORKS OF ART AND COCKTAIL PARTY EVENT

OUR EVENTS

FINANCIALS

OUR SPONSORS

On Wednesday, January 25th 2017 Global Images USA hosted an art gallery viewing and cocktail evening showcasing iconic works from world-renowned photographers and artists at a private residence in Hollywood. Guests had the opportunity to enjoy beautiful art, great company, and award-winning locally brewed beer, cocktails, delicious food and entertainment. A portion of proceeds from the sale of these art pieces benefited The Pacific Mesothelioma Center.

This event was geared towards art collectors, photography fans, and old Hollywood aficionados. The prints and original art works for sale covered a broad spectrum of themes, offering something of interest for everyone. The eclectic assortment included high fashion prints, intimate portraits, behind the scenes old Hollywood elite, aerial photography, and conceptual oil and acrylic paintings.

Guests had the opportunity to purchase these works through a silent auction with a minimum bid and a buy-out option. The lists of artists whose works were for sale included Helmut Newton, Frank Worth, David LaChapelle, Timothy White, Daniel Furon, Arney Freytag, Stephan Wayda, Ann McFerran, and many more.

Additionally, some of the artists were present at the event, offering perspective and background on their work and personally signing their newly acquired prints.

The annual open house showcased the innovative research conducted at PMC at their in-house research laboratory in Los Angeles. This event was held at one of the two laboratories that PHLBI operates. The other laboratory is the David Punch Worthington Laboratory, located at the David Geffen School of Medicine at the UCLA Medical Center.

Attendees met the PMC researchers, learned about the exciting research taking place in the lab, ate delicious food from French- Moroccan eatery Chez Marie, and watched student interns perform live demonstrations.

Individuals new to PHLBI are encouraged to attend next year’s open house so they can learn more about the institute and its exciting research, and learn more about events held throughout the year to raise awareness and funds for research.

“My father was diagnosed with mesothelioma in 2016 and was given an estimated year to year and a half to live. This doctor said that the disease was rare and there wasn’t much he could offer except palliative measures. I refused to give in to this and had started my own research when I came across Dr. Cameron at UCLA who specializes in mesothelioma. While working to get my father seen by this specialist my mother and I were offered the opportunity to participate in a caregiver support group organized by the PHLBI, which was extremely helpful and often times a source of hope for my family. Sharing experiences and tips on how to care for family members helped us to feel less helpless, knowing that whatever my dad was going through was experienced before by someone else and that there were ways to help him was reassuring. The PHLBI also organizes different events, such as a 5k walk/run/hike to fundraise for mesothelioma research which my family has attended the past 2 years. Getting to see the survivors, fighters and supporters work towards helping find other forms of treatment is truly inspiring. I am thankful for the PHLBI and all the work they do for those suffering from mesothelioma.” ~ Client

29 2017 ANNUAL REPORT

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OUR TEAM

WHO WE ARE

SURVIVOR STORIES

OUR EVENTS

FINANCIALS

Pacific Heart Lung and Blood Institute Financial Statements for the Year ending December 31, 2017

FINANCIALS

2017 Revenue

Pacific Heart Lung and Blood Institute Statement of Function Expenses for the year ended December 31, 2017

676,153

Fundraising contributions

273,336

Investment income

49,773

Total revenue

999,262

Total expenses

Program service expenses

Management Fundraising and general expenses expenses

Compensation

499,105

327,609

171,496

-

Compensation

499,105

Rent

64,174

34,894

29,279

-

Rent

64,174

Lab expenses

90,137

90,137

-

-

Lab expenses

90,137

Employee benefits

25,505

14,491

11,013

-

Fundraising events

24,584

Contract labor

7,175

2,152

4,305

717

Employee benefits

25,505

Depreciation

13,794

13,794

-

-

Contract labor

7,175

Insurance

7,411

2,963

3,707

741

Depreciation

13,794

Advertising

4,010

-

-

4,010

Insurance

7,411

Grants paid

12,190

12,190

-

-

Advertising

4,010

Other expenses

39,099

10,480

25,133

3,486

Grants paid

12,190

Total functional expenses

762,600

508,711

244,934

8,955

Other expenses

39,099

100.00%

66.71%

32.12%

1.17%

Pacific Heart Lung and Blood Institute Fundraising Activities for the year ended December 31, 2017 Fundraising Events

OUR SPONSORS

Contributions

Event Revenue

273,336

Event Expenses

24,584

Net fundraising revenue

248,752 91.01%

Expenses

Total expenses

787,184

Revenue less expenses

212,078

Total assets

1,082,209

Total liabilities

14,743

Net assets or fund balances

1,067,466

31 2017 ANNUAL REPORT

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OUR SPONSORS $1M AND ABOVE

WHO WE ARE

SURVIVOR STORIES

OUR EVENTS

FINANCIALS

OUR SPONSORS

Worthington, Roger

PLATINUM $20,000 - $1M

Baukholt, Hans and Mary Belvedere, Noella Bergquist, Erwin Caron, John and Suzanne Crawford, Patricia Curran, Florence Donnelly, Jeffrey Donnelly, Julie English, Michael Farag, Nasseem and Sena Harriet H. Samuelsson Foundation Hatfield, Meris Hazen, Sandra Jackson, Jacqueline and Robert Jager, Jacob and Norma Jarvis, Sonia Jarvis-Bayek, Sonia Jasniy, Victor Johnson, Michael and Nicole Kazan McClain Partners Foundation Koch, Irene LaMonica, Peter and Exine Losch, Maria Mandelbrot Law Firm McCarthy, Rosanne Sharkey, Joanne Simmon Cooper LLC “Simon Greenstone Panatier Bartlett“ Sutherland, Mike Susie Kay Keeton Foundation “The Oregon Community Foundation “ The Peterson Firm “The Richard M. Schultze Family Foundation“ Tran, Mongdon Vanderhyde, David and Pilar Waters & Kraus, LLP Worthington & Caron PC Worthington, David

GOLD: $10,000 $19,999.99

Bittner, Michael Bodnar, John CD Medical Legal Consulting Chomo, Antony Ganoe, Rosemarie “Heat and Frost Insulators and Asbestos Workers“ Keeney, Rick Latham, Terry and Maryla

Lepore, Geri Markovich, John “Napoli Bern Ripka & Associates LLP “ Sanchez, Joel Schuyler, Joanne Sommerfield, Margo Stirdivant, Rosemary Vitale, Robert Winkel, John Worthington, Juniel

SILVER $1,000 - $9,999.99

“American General Private Security Corp“ Amgen Inc Anderson, Henrik and Monica Armand, Jean-Louis Arnold, Susan Asbestos.com Baeza, Jennipher Belfer, Lawrence Bell, Bruce Benzeevi, Benny Bergin, Margaret Blanks, Joesph and Kim Blonsky, David and Cheryl Botti, Daniel Brown, Nicholas Brown, Koro & Romag, LLP Buhler-Zamudio, Monica Burrows, Elizabeth Anne Burton, Sherie Cameron, Clare Cameron, Elizabeth Cameron, Robert Capitol Group Charitable Foundation Card, Melissa Casey, Gerald and Judith Christiansen, Allen Churchill, Richard Costa, Peter and Teresa Curran, Michael Demster, Lawrence Elfman, Danny and Bridgette “Employees Community Fund of Boeing California“ Evens, Laura Evens, Virginia The Farrise Firm Feng, Sue-Ying First American Title Insurance Freisen, Doris Fukuda, Susan George, John Ghavami, Dana Ghavami, Maryam Ghavami, Nina Ghavami, Zia

Gilpatric, Cliff and Kay Gold Law Firm Goline, Holly Gori Julian and Associates Greeff, Derek Grgich, Marilyn and Reed Ha Zarlin Construction Harowitz & Tigerman, LLP Hart, Vicki Herford, Douglas Jarvis, Charles JR Jarvis, James Julian, Gori and P.C, Associates Keisling, Kathryn Keller, Fishback & Jackson LLP Kovacs, Maria and Zoltan Kraus, Waters and Paul, Lange, Erik Lange, Irene “Los Angeles Airport Police Athletics and Activities League“ Losch, Joseph Luebke, Kurt Lundy, Charles Marx, Wesly and Judith Mascoli, Eugene and Lucille “McLaughlin, Kourtni“ Michail, Angelene Michail, Sobhi Mintra, Sanjit Mitra Family Giving Account Munoz, Arturo and Martha Northrop Grumman One Beacon Charitable Trust Ozanian, Rhonda Perkins Foundation Perone, Todd Phillips, Charity “Physicians Foundation Medical Associates “ Pilato, Toney Poling-Schmidt, Marta and Stephan Porteous, Joan and Don Prime Healthcare Services Putman, Geneva Quest Diagnostics Radovcich, George and Jeana Reed, Lorraine and Tom Reinholz, Kristy Renehan, Joan Rickbeil, Jane Rocket Entertainment, INC Rosenfeld, Dennis Rourke, Lea Savitala, Radha Schackne, Kathy Shank, Mary Sherman, Michael “Simmons Mesothelioma Foundation “

Sipos Foundation South Coast Hospice Speziali Greenwald & Hawkins Stanley, David Sutherland, Suszie The Tagliaferri Foundation Taylor, Stanley and Kathleen The John H. Johnson Charitable Union Bank Vitale, Jamie Weitz & Luxenberg Welter, Kristin

BRONZE $1 - $999

A-Hi Computers & Electronics Abdun-Nur, Glen and Donna Abdun-Nur, Donna Abtin, Fereidoun Acker, Kimberly Acorn Appliance Service Adams, Cindy Adams, Dorothy Adams, Erik Adams, Lea Adams, Matthew Adams, Tom and Laura Adams, Victoria Aegerter, Christina Aguilar, Louis and Linda Ahn, Raymond Aid to Injured Motorcyclists Aiello, Paul and Betty Aipa, Val Akerstrom, Carmen and Thomas Al Lowe Construction Alba, Lauren Alcina, Gerald Aldrete, Florentina Aldrich, Lynne Aldrich, Marylyn Alexander, Jim and Bene Align Health Center Almaraz, Patricia Alonzo, Eileen Alper, Michelle Alphabet Soup Puppeteers Altmann, Jessell Altmann, Jim Alviar, Roselyn Amalfitano, Frank and Susan “American Contractors Indemnity“ American Legion Riders Chapter 741 AML Communications Anderson, Brian Anderson, Carol and Jon Anderson, Dana and Sue Anderson, Deborah Anderson, Gene and Shirley

Andlovec, Wayne Andonian, Michael Andreanelli, Nora Andrews-Willis, Vickie Angelopoulos, Patty Ankenbrandt, David Anshus, John Antenucci, James Anthold, David Antrim, Erin and Michael Anwar, Shannon Apeles, Filoteo Aquino, Joji Aranda, Carolyn Arbetman, Joan Archard, Kathleen Archer-Allen, Denise Archhuleta, Lucy Arevalo, Lauren Arevalo, Tony Arias, Jose and Tonia Arias, Valerie Arkelian, Airapet Arlen, Michael Arlen, Phebe Armand, Christopher Armand, Gregory Arnst, Karen Aronson, Max Arretche, Jesse Arrozogaray, Alicia Arvizu, Isaiah Arzola, Jessica “Asbestos Disease Awareness Organization“ Asbestos Workers Local Ashbaugh, Sally Ashbaugh, William and Sara Askin, Carol Asp, Kathryn Aspen Land Company Aston, Robert and Patricia Atkinson, Caral Atwood, John Augelepi, Tom Ault, Del and Patricia Austin, Gerald and Betty AutoFinders, Inc. Avery, Stuart Avila, Rick Awrey, Jennifer Awrey, Julianne Ayala, Saul and Serena Aycock, Amanda Babcock, Stephanie Baby Sacks Baca, Leroy Bach, James Backhus, Leah Backman, Stevie Bacon, Pamela Baer, David Baeza, Andrea Baeza, Caleb Baeza, Chris Baeza, Colette and Michael Baeza, Gabriel Baeza, Jennipher and David Baeza, Justin Baeza, Michael Baeza, Nicole Noemi Baeza Baeza, Rebecca Baeza, Richard Baeza, Ruben Baeza, Steven Baeza, Vana Baganz, Pat Bailey, Colleen Baker, Dona and Joseph

Baker, Joann Baker, Roman and Jennifer Balesteri, Sandy and Joesphine Balestrieri, Jeanne and Neal Balolong, Rachelle Balsano, Lillian Balsano, Vittorio Bandler, James and Dianne Baranic, Robert and Phyllis Barbieri, Lucretia Barcroft, Lois Bargar, Lisa Barillas, Christian Barlcom, Barry Barlett, Erin Barlow- Williams Realty Barnett, Donald Barnett, Larry Barra, Gino and Christine Barron, Sharon Bartel, Robert Bartlett, Jack Bartlett, Jennifer Bartlett, Michael Basso, Genevieve Baugher, Fred Baumann, Sam Bautista, Raquel Bayek, Edward Bayek, Ronald Beach Garden Cafe Becerra, Olivina Beck, Karlene Beckel, Len and Phyllis Beckendorf, Steven and Denise Becker, Mervyn and Elaine Beckman, Martha Behen, Timothy and Denise Beley, Katie Bell, Ina and John Bell, Mary Beller, Robert and Kathryn Belvedere, Armando Belvedere, Devyn Belvedere, Dustin Belvedere, Kara Belyavsky, Lilit Bendot, E Jeanne Benrich Service Company Benstead, Nancy Bentley, Jim Bentovoja, Barbara Beoshanz, Carol Bereni, Sylvie Bergantz, Raenell Bergin, Dominic Bergin, Eileen and Dan Bergin, Jason Bergin, Peggy Bergman, Richard Berkley, Roger Berliner, Robert Bernal, Crystal Bernal, Jesus and Vilma Bernard, Jeanne Berrebi, Ellie Beserra, Alice and Edward Bessette, Normad and Jessica Betancourt, Allen and Susan Beyersdorf, Allen Beyersdorf, Andreas Beyersdorf, Lenora Beyersdorf, Lieselotte Beyne, Bruce and Judith Bidet, Sylvie Bidwell, Geraldine Bilderain, Christine and Olsen, Lillian Birch, Michele Bird, Tracee

Birkemeyer, Doris Bishop, Carl and Ella Bishop, Les Bissell, Michael Bizzini, Karen Blacklock, Eunice Blair, Robert and Janet Blanco, Carol Blatt, Sara Blatter, Lois Blau, Keith Blazewich, Patricia Blonsky, Barry Blonsky, Cheryl Blonsky, Dave Blonsky, Jerry Blonsky, Katie Blonsky, Natasha Bluekube Technologies “Blumenfeld-James “ Blumenfield-James, Athena Blumenfield-James, Eleni Blumenfield-James, Jordan Blumenfield-James, Persephone Blundell, David BMW BNL Designs Boatwright, Camille Bober, Steve Bodnar, Joell Boecker, Lisa and Donald Bonsell, George and Vera Booth, Peter Booth, Shannon BOP-A-RAZZI Productions Borchard, Cynthia Borkar, Gitanjali Bortolott, Richard and Linda Bostrom, Herbert and Patricia Bothwell, Claire Bothwell, Jillian Bothwell, Katrina Bothwell, Will Boudreau, Carla Boudreau, James and Carla Boudreau, Matthew Bouza, Robert Boyle, Anna and Terrance Boyle, Timothy and Nadine Brabner, William and Patricia Bradford, Timothy Bradfute, Sherie Brady, Kevin Bragg, Ray and Bragg, Karolyn Brannis, John and Joyce Breese, Oliver Breiner, Charles Brenner, Michelle Brenner, Suzanne Brigham Family Trust Brioso, Elizabeth Brisbane, Lucille Britt-Smith, Linda Brodkin, Selma Brooks, Mai Brosterman, Julie and Marc Browman, Linda Brown, Ivanna Brown, James Brown, Maxine Brown, Russ Brown, Tim Bruno, Michael and Sharon Brusca, Joe Brzezinski, Jacek and Brzezinnski, Krystyna Buccieri, Gail Buck, Joyce Bunde, Rex Burfeind, Mary

Burgess, Fred and Lorraine Burja, Joseph and Sarah Burns Environmental Services Burton, Jennifer Bush, Kathy Bustamante, Ernie and Lucia Bustamante, Ernie Bustamante, Lucia Bustillos, Albert Butcher, Jaquie Butler, John Butvich, Frank Byfield, Kaily Bynder, Jodi Bynder, Madeline Byrd, Ronnie Byun, Ernie Caballero, Teresa Cabral, Dovie Cabrera, Ashield Cabrera, Yolanda Cabuang, Rene Cadiente, Helen Cahill, Karen “Cal Coast Construction Specialists, Inc “ Calandrino, Curtis Caldwell, Megan Califano, Irene Califano, John Califano, Pat and Irene Califano, Rosary Califano, Rosary Calivg, Johnathan and Estee Callaghan, George Callaghan, Sybil Camacho, Feather Camarillo Health Care District Cameron, Angela Cameron, Barbara Cameron, Bill Cameron, Robert Cameron, Scott Cameron, Steven and Kay Cameron, William Camino, Janeen Cammareri, Gracelyn Campadonia, Lauren Campbell, Finola Campbell, John Campopiano, Tony Campos, Henry and Alice Campos, Thais Candelaria, Ma Dulce Cannon, Dana Canuso III, Vito and Canuso, Renee Capiro, Nina Caponetto, John Caporusso, Joseph and Clarice Capuano, Chris Caraveo, Joyce Card, Melissa Cardarelli, Jennifer Carden, Anthony Carden, Edward Carden, Jim and Anne Cardenad, Linda Carlin, John Carmichael, Cindy Carnegie, Winifred Carolyn Serling Trust Caron, Suzanne Carpenter, Jack Carpenters and Joiners of America Carradine, Stephon Carroll, Allison Carroll, Deborah Carson, John Carson, Leslie

Carson, Thomas and Shirley Carswell, Rosalia and James Cartwright, Christian and Chip Carvajal, Anaelisa Carvajal, Kimberly Casady, Mark and Holly Casares, Alma Casey, Sharon Cashion, Dewey and Dorris Cassell, Marc Cassidy, Jayne Cassidy, June Castaneda, Dorothy Castaneda, Susan Castillo, Jennifer Castillo, Melinda Castrege, Carina Castro, Ely Cebrini, Helen Champion, Craig and Sharon Chan, Kenny and Shelley Chan, Kitty Chan, Natasha Chang, Calvin Chawki, Rose Chaz Distributing LLC Cheingpratoom, Mali Chen, Julia Chen, Justin Chen, Lydia Cheski, Richard Chespak, Lindsey Chespak, Margaret Chifo, Peter Chima, Rupinder Chimarusti, Mark Ching, Steven Chinn, Julie Chiu, Mike Chomo, Nancy Chona, Priya Christ, Richard Christen, Elizabeth Christian, Roberta Chung, Myung Churchill, Randy Cimorell, Eileen Ciolino, Peter and Christina Cirri, Lauren Ciulla, Anthony Ciuro, Lauren Clair, Collette Clark, Janet Clarke, Jim Clarke, Pam and Dick Clay, Cindy Clement, Gail Clenens, John and Elizabeth Clifford, Angela Coco, Olivia Cohen, Susan Colbert, Devon Coleman, James Coleman-Ackerman, Cathy Coles, Leslie Ann Colicchio, Paul Colman, Deborah Colton, Mike and Theresa Conley, Daniel and Kathleen Conner, Tom and Kay Considine Cortelyou, Honora Conte, David Conte, Marsha Contreras, Leonardo Contreras, Raul Contreras, Ruby Conway, Connie Conway, Conrad and Shirley Coons, Holly Coons, Terry

33

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OUR EVENTS

FINANCIALS

OUR SPONSORS

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