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Solvent Compatibility Guide for Seals The table below contains general guidelines for choosing the best seal material for your application. Actual results may vary depending on operating conditions such as temperature and concentration of solvent, etc. For a specific recommendation based on your operating conditions, please contact OPTIMIZE TECHNOLOGIES SUPPORT. R = Recommend G = Good (better choice might be available) N = Not Recommended (material degradation probable)

Mobile Phase Solvent Acetamide Acetone Acetonitrile Acrylonitrile Aqueous/Aqueous Buffered Benzene Butanol Carbon Tetrachloride Chloroform Cyclohexane Cyclohexanone Dichloroethane Dichloromethane Dimethyl Formamide (DMF) Dimethyl Sulfoxide Ethanol Ethyl Acetate Ethyl Ether Ethylene Diamine Ethylene Glycol Heptane Hexane Iso-octane Isopropyl Alcohol Methanol Methyl Ethyl Ketone Pentane Pyridine Tetrahydrofuran (THF) Toluene Xylene

OPTI-SEAL® (UHMW-PE) R N R R R N R N N N N N N R R G N N R N G N N R R G N G N N G

ITB™ (PTFE) G R G G G R G R R R R R R N N R R R G R R R R G G R R R R R R

INNOVATIVE HPLC, UHPLC & LC/MS PRODUCTS

t 800.669.9015

f 503.669.9995

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Seals and Pistons  

a campatibility guide

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