New Force in CINV Annotation

Page 1

B63 @3H=<71 /<<=B/B32 A/:3A /72


7<B@=2C17<5 @3H=<71´B63 =<:G A7<5:3 =@/: 2=A3 <3C@=97<7< <9 @313>B=@ /<B/5=<7AB @3H=<71 1=@3 ;3AA/53 @3H=<71 Wa bVS O\bWS[SbWQ b`SOb[S\b bVOb eWbV O aW\UZS ^]bS\b ]`OZ R]aS ]T @3H=<71 ^`SdS\ba QVS[]bVS`O^g W\RcQSR \OcaSO O\R d][WbW\U 17<D T]` O TcZZ # ROga O\R Wa QZW\WQOZZg ^`]dS\ b] VSZ^ ^ObWS\ba [OW\bOW\ bVSW` ROWZg Tc\QbW]\OZ ZWdW\U 7a bVS`S O \SSR-

EVOb @3H=<71 QO\ R]

2Sa^WbS bVS eWRSa^`SOR caS ]T # 6B!a [O\g ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ O\R OZa] bV]aS `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g abWZZ acTTS` T`][ 17<D /a g]c QO\ aSS T`][ bVS PO` U`O^V PSZ]e SdS\ eWbV H=4@/< O\R RSfO[SbVOa]\S c^ b] #% ]` #& ]T ^ObWS\ba Sf^S`WS\QSR 17<D Rc`W\U bVS # ROga T]ZZ]eW\U SWbVS` VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g `Sa^SQbWdSZg BVS `O\US ]T ^ObWS\ba abWZZ Sf^S`WS\QW\U 17<D W\ bVS PO` U`O^V Q][Sa T`][ bVS # ROg TOWZc`S \c[PS`a ]T bVS Q]\b`]Z O`[a W\ bVS O^`S^WbO\b O\R @3H=<71 QZW\WQOZ b`WOZa BVSaS abcRWSa eS`S caSR PSQOcaS abcRWSa ]T ]ZRS` # 6B!a RWR \]b SfO[W\S 17<D ]dS` # ROga bg^WQOZZg OQcbS( ROg ]` ROga b] ! 7b Wa dS`g W[^]`bO\b b] SRcQObS Qcab][S`a OP]cb bVS aWU\W¿QO\b c\[Sb \SSR O\R b] VSZ^ bVS[ `SQ]U\WhS bVOb bVS W\QWRS\QS ]T 17<D ]dS` # ROga eWbV []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g Wa dS`g aW[WZO` b] bVS W\QWRS\QS eWbV VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

@3H=<71 ^`SdS\ba 17<D T]` O TcZZ # ROga eWbV Xcab O aW\UZS R]aS ' ]T ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g ;]`S bVO\ % ]T ^ObWS\ba `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g @3H=<71 VSZ^a ^ObWS\ba [OW\bOW\ bVSW` ROWZg Tc\QbW]\OZ ZWdW\U %% ]T ^ObWS\ba eS`S OPZS b] U] OP]cb bVSW` ROWZg ZWdSa eWbV]cb 17<D ZW[WbW\U bVSW` OPWZWbg b] Tc\QbW]\

2Sa^WbS bVS eWRSa^`SOR caS ]T # 6B!a [O\g ^ObWS\ba abWZZ acTTS` T`][ 17<D

EVg O aW\UZS ]`OZ R]aS0SQOcaS Wb Wa ^]bS\b Wb Wa SOag O\R Wb UWdSa QZW\WQWO\a U`SObS` Q]\b`]Z ]dS` OR[W\Wab`ObW]\ O\R 17<D ^`SdS\bW]\ Oa O eV]ZS 7\ [O`YSb `SaSO`QV ]\Q]Z]UWaba O\R ]\Q]Z]Ug \c`aSa PSZWSdSR bVOb AW\UZS =`OZ 2]aS @3H=<71 eOa []`S ^]eS`TcZ bVO\ bVS ! ROg ]`OZ `SUW[S\ ]T 3[S\R O^`S^WbO\b BVSg OZa] TSZb bVOb Wb e]cZR [OYS bVSW` O\R bVSW` ^ObWS\ba¸ ZWdSa SOaWS`

>/B73<BA AB7:: 3F>3@73<17<5 17<D 23A>7B3 B@3/B;3<B E7B6 =<2/<A3B@=< /<2 23F/;3B6/A=<3 =D3@ # 2/GA AbcRg

7[^]`bO\bZg Qcab][S`a eS`S VWUVZg []bWdObSR Pg bVS OPWZWbg b] ^`SdS\b 17<D T]` O TcZZ # ROga 1c``S\b O\bWS[SbWQa TOZZ aV]`b Ob SWbVS` ROg # 6B!a ]` ROg ! 3[S\R 1]dS`W\U P]bV bVS OQcbS O\R RSZOgSR ^VOaSa ]T S[SaWa eWbV O aW\UZS R]aS ^`]dSR b] PS bVS ab`]\USab RWTTS`S\bWOb]` T]` @3H=<71 7\ TOQb eVS\ Sf^]aSR b] bVS ^`]RcQb ^`]¿ZS T]` @3H=<71 P]bV VWUV O\R Z]e 3[S\R caS`a ZO`USZg ^`STS``SR @3H=<71 ]dS` 3[S\R

6756 DA :=E 3;3<2 CA3@A

&

&

$

$

AbcRg

&

>/B73<BA

B=> @3/A=<A 4=@ >@343@3<13 4=@ @3H=<71 =D3@ 3;3<2

>@=2C1B >@343@3<13

!

!" #%

" #&

abWZZ Sf^S`WS\QS 17<D

abWZZ Sf^S`WS\QS 17<D

6756:G 3;3B=53<71 163;=B63@/>G

;=23@/B3:G 3;3B=53<71 163;=B63@/>G

$

"

#"

$

"

"

!$

'

#

&

@3H=<71

3[S\R

:]e 3[S\R CaS`a

0]bV O`S bVS aO[S

!$

"

<SWbVS` @3H=<71 ]` 3[S\R

6WUV 3[S\R CaS`a

#

$

0SbbS` STTWQOQg

>`STS` ROg b`SOb[S\b R]aS

:]e 3[S\R CaS`a

7[^`SaaWdS RObO

6WUV 3[S\R CaS`a

3[S\R Wa O `SUWabS`SR b`ORS[O`Y ]T ;S`QY 1] 7\Q

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


EVg O`S a] [O\g abWZZ acTTS`W\U/QQ]`RW\U b] O ac`dSg Pg 5`c\PS`U Sb OZ ]\Q]Z]UWaba O\R ]\Q]Z]Ug \c`aSa aWU\W¿QO\bZg c\RS`SabW[ObS bVS W\QWRS\QS ]T 17<D 7\ bVWa [cZbW\ObW]\OZ ^`]a^SQbWdS ]PaS`dObW]\OZ abcRg ]T ^ObWS\ba `SQSWdW\U SWbVS` VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g <+ '& ]\Q]Z]UWaba ^`SRWQbSR bVOb ]\Zg ' ]T ^ObWS\ba e]cZR Sf^S`WS\QS 17<D eVWZS ]\ O # 6B! O\R RSfO[SbVOa]\S) \c`aSa ^`SRWQbSR # BVS `SOZWbg eOa bVOb # ]T ^ObWS\ba Sf^S`WS\QSR aWU\W¿QO\b S[SaWa eVWZS ]\ bVS abO\RO`R O\bWS[SbWQ `SUW[S\ BVSaS RObO Tc`bVS` `SW\T]`QS bVS \SSR T]` <9 cbWZWhObW]\

>3@13>B7=< DA @3/:7BG 7<1723<13 =4 23:/G32 3;3A7A 7< >/B73<B @3137D7<5 6756:G 3;3B=53<71 163;=B63@/>G"

>3@13<B

$

#

"

BVS Qc``S\b <9 [O`YSb 3[S\R VOa PSS\ ]\ bVS [O`YSb \SO`Zg $ gSO`a) V]eSdS` ]\Zg % ]T VWUVZg O\R # ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g ^ObWS\ba O`S `SQSWdW\U O\ <9 1C@@3<B <9 CB7:7H/B=< E7B6 6756:G 3;3B=53<71 163;=B63@/>G#

% G3A

#

'

7[^]`bO\bZg [O\g QVS[]bVS`O^WSa ^S`QSWdSR b] PS []RS`ObSZg S[Sb]US\WQ aV]cZR OQbcOZZg PS QZOaaW¿SR Oa VWUVZg S[Sb]US\WQ BVS 6SaYSbV 3[Sb]US\WQWbg 4]`[cZO Wa O dOZcOPZS b]]Z bVOb eWZZ PS caSR b] SRcQObS ]c` Qcab][S`a OP]cb bV]aS QVS[]bVS`O^g `SUW[S\a bVOb aV]cZR OZeOga PS OQQ][^O\WSR Pg @3H=<71 ^Zca O # 6B! O\R RSfO[SbVOa]\S 1O^bc`W\U []`S ]T bVS []RS`ObS ^]^cZObW]\ eWZZ PS Q`WbWQOZ b] bVS acQQSaa ]T @3H=<71

1C@@3<B <9 CB7:7H/B=< E7B6 ;=23@/B3:G 3;3B=53<71 163;=B63@/>G#

# G3A

;SO\ ]\Q]Z]UWab ^`SRWQbW]\

;SO\ @< ^`SRWQbW]\

/QbcOZ ^ObWS\b Sf^S`WS\QS

&! <= <]b @SQSWdW\U O\ <9

EVS`S Wa bVS ]^^]`bc\Wbg T]` @3H=<71BVS`S Wa b`S[S\R]ca ]^^]`bc\Wbg T]` @3H=<71 /a aV]e\ W\ bVS U`O^V PSZ]e ]\Zg ]T ^ObWS\ba eV] \SSR O\ <9 O`S Qc``S\bZg `SQSWdW\U ]\S /a bVS UcWRSZW\Sa abObS /:: ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g aV]cZR Ob bVS ¿`ab QgQZS `SQSWdS O\ <9 W\ ORRWbW]\ b] O # 6B! O\R RSfO[SbVOa]\S

17<D >/B73<B >=B3<B7/: B=E3@ #

'# <= @SQSWdW\U O\ <9

<]b @SQSWdW\U O\ <9

@SQSWdW\U O\ <9

=\Q]Z]UWaba O\R ]\Q]Z]Ug \c`aSa US\S`OZZg TSZb bVOb 3[S\R eOa O dOZcOPZS O\bWS[SbWQ T]` bV]aS ^ObWS\ba eV] TOWZ ]\ O # 6B! O\R RSfO[SbVOa]\S OZ]\S BVSg []ab ]TbS\ `SaS`dS 3[S\R T]` acPaS_cS\b QgQZSa ]T QVS[]bVS`O^g ]\QS O ^ObWS\b VOa Sf^S`WS\QSR aWU\W¿QO\b 17<D Rc`W\U bVSW` ¿`ab QgQZS BVWa Wa ]T bVS Vc`RZSa eS \SSR b] ]dS`Q][S W\ ]`RS` b] ]^bW[WhS c^ bOYS ]T @3H=<71 7\ `SaSO`QV eS ZSO`\SR bVS`S O`S aSdS`OZ `SOa]\a T]` bVS [W\W[OZ caS ]T 3[S\R( /QQSaa´RWT¿QcZb ^`]QSaa b] USb ^`W]` OcbV]`WhObW]\

" % ;; D7A7BA /@3 <9 3:7570:3 0CB <=B B@3/B32

1]ab b] bVS ^ObWS\b

:OQY ]T acT¿QWS\b Y\]eZSRUS ]` [Wa^S`QS^bW]\a `SUO`RW\U S[Sb]US\WQWbg ]T QVS[]bVS`O^g `SUW[S\a

1][^ZWO\QS eWbV O ! ROg ]`OZ `SUW[S\

&

$

#"

"

&

''

;O`YSb 0cWZRW\U

2WaQ]\\SQb PSbeSS\ OQbcOZ ^ObWS\b Sf^S`WS\QS O\R ^VgaWQWO\ O\R \c`aS ^S`QS^bW]\ ZOQY ]T Q][[c\WQObW]\

@SORg ASb 5] <]e bVOb g]c VOdS a][S POQYU`]c\R W\T]`[ObW]\ Wb Wa bW[S b] USb b] bVS VSO`b ]T bVS @3H=<71 QO[^OWU\ O\R bVS RObO bVOb ^`]dS @3H=<71 ^`]dWRSa # ROg 17<D ^`SdS\bW]\ eWbV O aW\UZS ]`OZ R]aS BVS `S[OW\RS` ]T bVWa UcWRS eWZZ bOYS g]c abS^ Pg abS^ bV`]cUV bVS @3H=<71 aOZSa OWR O\R ^`]dWRS Q]`S ]PXSQbWdSa aO[^ZS aOZSa [SaaOUSa O\R W[^]`bO\b TOQba

B]bOZ QVS[] ^ObWS\ba dWaWba

6WUVZg O\R ;]RS`ObSZg 3[Sb]US\WQ 1VS[]bVS`O^g

@SQSWdS O\bWS[SbWQ

B`SObSR eWbV # 6B!

B`SObSR eWbV <9 O\bOU]\Wab

/ZZ [OX]` O\bWS[SbWQ UcWRSZW\Sa `SQ][[S\R bVS caS ]T O\ <9 W\ OZZ 631 ^ObWS\ba O\R W\ aSZSQbWdS ;31 ^ObWS\ba /ZbV]cUV OZ[]ab OZZ ^ObWS\ba R] `SQSWdS O # 6B! Oa W\RWQObSR Pg bVS [OX]` UcWRSZW\Sa []ab R] \]b `SQSWdS O\ <9

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


B63 @3H=<71 :/C<16 1/;>/75<

A/:3A /72 1=D3@

BVS 1]\QS^b

1]`S ]PXSQbWdS

BVS Q`SObWdS Q]\QS^b T]` @3H=<71 RS[]\ab`ObSa bVS ^]bS\Qg ]T bVS \Se aW\UZS ]`OZ R]aS <9 O\R WZZcab`ObSa eVOb bVOb ^]bS\Qg Q]cZR [SO\ b] ^ObWS\ba

BVS ]PXSQbWdS ]T bVS Q]dS` Wa b] W\b`]RcQS Qcab][S`a b] O ^]eS`TcZ \Se T]`QS T]` 17<D ^`SdS\bW]\ B VS Q]dS` ]T bVS aOZSa OWR OQba Oa O R`O[ObWQ W\b`]RcQbW]\ ]T O \Se ^`]RcQb T]` 17<D ^`SdS\bW]\ BVS ab]\S 17<D Wa O ab`]\U RWT¿QcZb b] ^S\Sb`ObS ]PXSQb `SW\T]`QW\U bVS ^]bS\Qg ]T O aW\UZS ]`OZ R]aS Oa Wb Wa OPZS b] STT]`bZSaaZg µPZOab bV`]cUV¶ 17<D BVS VSORZW\S OUOW\ `SW\ T]`QSa bVS ^]eS` ]T AW\UZS =`OZ 2]aS @3H=<71

BVS ^]eS`TcZ @3H=<71 ^WZZ e`O^a O aVWSZR O`]c\R bVS ^ObWS\b Q][[c\WQObW\U Q]\bW\c]ca 17<D ^`SdS\bW]\ BVWa U`O^VWQ RS[]\ab`ObSa bVS ^ObWS\b S\R PS\S¿b´\] 17<D S_cOZa O PSbbS` QVO\QS b] U] OP]cb ROWZg ZWdW\U AW\QS bVWa ^ObWS\b Wa ^`]bSQbSR Pg @3H=<71 aVS Wa OPZS b] ^`S^O`S O [SOZ´aWUVba O\R a[SZZa R]\¸b P]bVS` VS` AVS Wa SdS\ OPZS b] S\X]g bVWa bW[S eWbV VS` Z]dSR ]\S

B VS @3H=<71 ^WZZ O\R bVS µPcZZSb ab`SO[¶ PSQ][S O\ ]e\OPZS P`O\RW\U WQ]\ Oa aV]e\ W\ bVS Q]`S dWacOZ

7<B@=2C17<5 / <3E <9 @313>B=@ /<B/5=<7AB /A >/@B =4 /< /<B73;3B71 @357;3<

A7<5:3 =@/: 2=A3 @3H=<71 7[^]`bO\b TOQb

AO[^ZS aOZSa [SaaOUS

7\ [O`YSb `SaSO`QV ]c` Qcab][S`a TSZb bVOb bVS Q]\QS^b ^]`b`OgSR µ^]eS` eWbV O ^c`^]aS ¶ 7b eOa W[^]`bO\b T]` bVS[ b] aSS bVS [SO\W\UTcZ W[^OQb bVOb @3H=<71 QO\ VOdS ]\ bVSW` ^ObWS\ba¸ ZWdSa BVSg OZa] c\RS`ab]]R bVS Q]`S [SaaOUS ]T R]aS O\R bVOb ^ObWS\ba eWZZ PS T`SS T`][ 17<D T]` # TcZZ ROga O\R bVS`ST]`S OPZS b] [OW\bOW\ ROWZg OQbWdWbWSa

µ <]e bVS`S Wa O \Se ^]eS`TcZ T]`QS T]` # ROg ^`SdS\bW]\ ]T QVS[]bVS`O^g W\RcQSR \OcaSO O\R d][WbW\U ¶

7[^]`bO\b TOQb < ]b OZZ ]T ]c` Qcab][S`a O`S TO[WZWO` eWbV bVS OPP`SdWObW]\ 17<D a] b] Od]WR Q]\TcaW]\ dS`POZWhS QVS[]bVS`O^g W\RcQSR \OcaSO O\R d][WbW\U eVS\ ^`SaS\bW\U bVWa ^OUS

/ <3E 4=@13 4=@ # 2/G >@3D3<B7=<

>S`a]\W¿QObW]\ ]T bVS Q]`S [SaaOUS @3H=<71 Wa bVS O\bWS[SbWQ b`SOb[S\b bVOb eWbV O aW\UZS ^]bS\b R]aS ]T @3H=<71 ^`SdS\ba 17<D T]` O TcZZ # ROga O\R Wa QZW\WQOZZg ^`]dS\ b] VSZ^ ^ObWS\ba [OW\bOW\ bVSW` ROWZg Tc\QbW]\OZ ZWdW\U AW\UZS ^]bS\b R]aS >`SdS\ba 17<D T]` O TcZZ # ROga >ObWS\ba [OW\bOW\ bVSW` ROWZg Tc\QbW]\OZ ZWdW\U

BVS @3H=<71 Z]U] O\R bOUZW\S a g]c g]c QO\ aSS bVS µae]]aV¶ O`]c\R bVS / ^ObWS\b W\ bVS Q]`S U`O^VWQ Wa OZa] O\ SZS[S\b W\ bVS @3H=<71 Z]U] BVS bOUZW\S µ=\S <9 2]aS # 2Og >`SdS\bW]\ ¶ _cWQYZg O\R STTSQbWdSZg Q][[c\WQObSa ]c` ^]aWbW]\W\U abObS[S\b O\R YSg RWTTS`S\bWOb]`a

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


>/53

>/53 !

=>3<7<5 AC;;/@G A>@3/2

AC;;/@G A>@3/2

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] dWacOZZg ^]`b`Og bVS ^ObWS\b PS\S¿ba ]T AW\UZS =`OZ 2]aS @3H=<71 O\R ^`]dWRS O ag\]^aWa ]T bVS ST¿QOQg RObO /a g]c QO\ aSS bVS ^WZZ VOa e`O^^SR O aVWSZR O`]c\R bVS ^ObWS\b bVOb eWZZ ^`]bSQb VS` T`][ 17<D T]` O TcZZ # ROga O\R S\OPZS VS` b] U] OP]cb VS` ROWZg ZWdW\U CaS bVWa a^`SOR Oa O _cWQY W\b`]RcQbW]\ O\R bVS\ []dS ]\ b] bVS RObO a^`SORa eWbVW\ bVS aOZSa OWR) bVWa a^`SOR QO\ OZa] PS caSR Oa O `S[W\RS` QOZZ ]` eVS\ bW[S eWbV Qcab][S`a Wa ZW[WbSR

AO[^ZS aOZSa [SaaOUS

/ <3E 4=@13 4=@ # 2/G 17<D >@3D3<B7=<

µ /a ^O`b ]T O\ O\bWS[SbWQ `SUW[S\ AW\UZS =`OZ 2]aS @3H=<71 ]TTS`a VWUV ST¿QOQg `ObSa O\R bVS [OX]`Wbg ]T ^ObWS\ba ]\ bVS @3H=<71 @SUW[S\ `S^]`bSR \] W[^OQb ]T 17<D ]\ bVSW` ROWZg ZWdSa ¶

6WUV ST¿QOQg `ObSa T]` # TcZZ ROga \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g Á

7[^]`bO\b TOQb

7<B@=2C17<5 / <3E <9 @313>B=@ /<B/5=<7AB /A >/@B =4 /< /<B73;3B71 @357;3<

AO[^ZS aOZSa [SaaOUS

A7<5:3 =@/: 2=A3 @3H=<71 A7<5:3 =@/: 2=A3 @3H=<71

µ 7¸R ZWYS b] W\b`]RcQS @3H=<71 bVS ]\Zg aW\UZS ]`OZ R]aS \Sc`]YW\W\ `SQS^b]` O\bOU]\Wab T]` # ROg ^`SdS\bW]\ ]T 17<D T]ZZ]eW\U VWUVZg O\R []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g ¶

&$ W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g Á Á

%! W\ []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

;OW\bOW\SR ]dS` " VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g QgQZSa

>ObWS\ba¸ ROWZg Tc\QbW]\OZ ZWdW\U [OW\bOW\SR W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g %% ]T ^ObWS\ba `S^]`bSR \] W[^OQb ]T 17<D ]\ ROWZg ZWdSa

0S ac`S b] S[^VOaWhS eWbV Qcab][S`a bVOb @3H=<71 Wa OZeOga caSR W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQa O # 6B! O\R Q]`bWQ]abS`]WR

BVS ]\Zg 2Og AW\UZS =`OZ 2]aS <9 /Za] OdOWZOPZS W\ O\ 7D =`OZ =`OZ @3H=<71 @SUW[S\

AO[^ZS aOZSa [SaaOUS

CaSR W\ Q][PW\ObW]\ eWbV [cZbWROg # 6B O\R RSfO[SbVOa]\S

AOTSbg ^`]¿ZS W\ P]bV ]`OZ O\R 7D 1Oa]^WbO\b R]Sa \]b W[^OQb bVS ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\ Rc`W\U Q]OR[W\Wab`ObW]\ @3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba BVS []ab Q][[]\ ORdS`aS `SOQbW]\a t W\ ^ObWS\ba b`SObSR eWbV @3H=<71 T]` bVS ^`SdS\bW]\ ]T 17<D( \Scb`]^S\WO OZ]^SQWO TObWUcS ZScY]^S\WO bV`][P]Qgb]^S\WO Q]\abW^ObW]\ O\R O\S[WO

AW\UZS =`OZ 2]aS ]` ! 2Og 7D =`OZ @3H=<71 W\ Q][PW\ObW]\ eWbV ]\RO\aSb`]\ RSfO[SbVOa]\S

][^ZSbS `Sa^]\aS + \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS [SRWQObW]\ T`][ ROga bV`]cUV # V]c`a 1 @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRWSa W\ ^ObWS\ba `SQSWdW\U VWUVZg <+& ]` []RS`ObSZg <+ '!! S[Sb]US\WQ QVS[]bVS`O^g

µ 7\ ORRWbW]\ b] bVS aW\UZS ]`OZ R]aS @3H=<71 Wa OZa] STTSQbWdS Oa O\ 7D `SUW[S\´' [U 7D ]\ ROg T]ZZ]eSR Pg # [U ]`OZ ]\ ROga O\R ! ¶

AO[^ZS aOZSa [SaaOUS µ BVS []ab Q][[]\ ORdS`aS SdS\ba eS`S \Scb`]^S\WO OZ]^SQWO TObWUcS ZScY]^S\WO bV`][P]Qgb]^S\WO Q]\abW^ObW]\ O\R O\S[WO ¶

Á

@3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa O\R \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^WSa >ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

7[^]`bO\b TOQb NEW

@3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>!/ R`cUa

BVS P`WRUS µ 4]` Tc`bVS` RWaQcaaW]\ b]ROg eVOb W\T]`[ObW]\ `SUO`RW\U \Se AW\UZS =`OZ 2]aS @3H=<71 e]cZR g]c ZWYS b] ZSO`\ []`S OP]cb-¶

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


>/53 "

>/53 #

C<;3B <332 ;=/

C<;3B <332 ;=/

1]`S ]PXSQbWdS BVS ]PXSQbWdSa ]T bVWa c\P`O\RSR a^`SOR O`S( Â’ 3abOPZWaV bVS \SSR T]` O\ <9 Pg RS[]\ab`Ob W\U bVS aWU\W¿QO\b c\[Sb \SSR´aSS ^OUS # ]T bVWa UcWRS T]` Qc``S\b <9 ^S\Sb`ObW]\ W\ bVS 17<D [O`YSb Â’ 6SZ^ Qcab][S`a `SQ]U\WhS bVOb bVS W\QWRS\QS ]T 17<D ]dS` # ROga eWbV []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g Wa dS`g aW[WZO` b] bVS W\QWRS\QS eWbV VWUVZg S[Sb]US\WQ QVS[]bVS`O^g Â’ 3f^ZOW\ V]e O\ <9 e]`Ya ag\S`UWabWQOZZg eWbV Qc``S\b # 6B!a b] ^`]dWRS ORRWbW]\OZ 17<D ^`SdS\bW]\

Â’ # 6B! `SQS^b]` O\bOU]\Waba O`S bV]cUVb b] e]`Y ^S`W^VS`OZZg ^`W[O`WZg W\ bVS Ucb Pg W\VWPWbW\U bVS OQbWdObW]\ ]T aS`]b]\W\´[]ab STTSQbWdS W\ OQcbS 17<D

µ /RRW\U O\ <9 bOYSa 17<D ^`SdS\bW]\ aWU\W¿QO\bZg TO`bVS` /a bVS [SQVO\Wa[ ]T OQbW]\ U`O^V ]\ bVS `WUVb aV]ea O `SUW[S\ Q]\aWabW\U ]T O\ <9 W\ Q][PW\ObW]\ eWbV O # 6B! O\R O abS`]WR PZ]QYa YSg `SQS^b]`a W\d]ZdSR W\ 17<D 0g PZ]QYW\U bVSaS YSg ^ObVeOga g]c QO\ ^`]dWRS U`SObS` 17<D ^`SdS\bW]\ T]` []`S ]T g]c` ^ObWS\ba ¶

Â’ ASZSQbWdS <9 `SQS^b]` O\bOU]\Waba O`S bV]cUVb b] e]`Y ^`W[O`WZg ]\ bVS QS\b`OZ \S`d]ca agabS[ Pg PZ]QYW\U OQbWdObW]\ ]T acPabO\QS >´[]ab STTSQbWdS W\ RSZOgSR 17<D

7[^]`bO\b TOQb

# 6B!a 6/D3 B/93< 17<D >@3D3<B7=< 4/@ /227<5 /< <9 B/93A 17<D >@3D3<B7=< A75<7471/<B:G 4C@B63@

5ZOf]A[WbV9ZW\S W\b`]RcQSR bVS ¿`ab SdS` # 6B!´ H=4@/<• ]\RO\aSb`]\

H=4@/< `Sd]ZcbW]\WhSR QO\QS` bVS`O^g Pg bOYW\U OQcbS 17<D [O\OUS[S\b T`][ b`SOb[S\b b] ^`SdS\bW]\ O\R UOdS VSOZbV QO`S ^`]dWRS`a U`SObS` Q]\b`]Z ]T eVS`S O\R V]e QVS[]bVS`O^g Wa OR[W\WabS`SR

AO[^ZS aOZSa [SaaOUS µ # 6B!a VOdS bOYS\ 17<D ^`SdS\bW]\ TO` 7\ '' 5A9 W\b`]RcQSR H=4@/< O\R VSZ^SR `Sd]ZcbW]\WhS QO\QS` bVS`O^g ¶

2Sa^WbS bVS eWRSa^`SOR caS ]T # 6B!a [O\g ^ObWS\ba abWZZ acTTS` T`][ 17<D !

/ `SUW[S\ Q]\aWabW\U ]T O\ <9 `SQS^b]` O\bOU]\Wab UWdS\ W\ Q][PW\ObW]\ eWbV O # 6B! `SQS^b]` O\bOU]\Wab O\R O Q]`bWQ]abS`]WR PZ]QYa YSg `SQS^b]`a W\d]ZdSR W\ 17<D

>/B73<BA AB7:: 3F>3@73<17<5 17<D 23A>7B3 B@3/B;3<B E7B6 =<2/<A3B@=< /<2 23F/;3B6/A=<3 =D3@ # 2/GA

7[^]`bO\b TOQb

AbcRg

Â’ 7\ [O`YSb `SaSO`QV [O\g VSOZbV QO`S ^`]TSaaW]\OZa VOR O dS`g ab`]\U Q]\\SQbW]\ eWbV 5A9 PSQOcaS ]T bVS VS`WbOUS eWbV H=4@/< BVSg `SQOZZSR bVS b`S[S\R]ca RWTTS`S\QS H=4@/< [ORS T]` bVSW` ^ObWS\ba BVS TOQb bVOb @3H=<71 Wa PSW\U W\b`]RcQSR Pg bVS [OYS`a ]T H=4@/< `Sa]\ObSR eSZZ eWbV Qcab][S`a O\R SZWQWbSR Q]\¿RS\QS

>/B73<BA

<9 @SQS^b]` <9 @SQS^b]` /\bOU]\Wab

AbcRg

1S\b`OZ >ObVeOg

!" #%

<9 @SQS^b]`a

abWZZ Sf^S`WS\QS 17<D

$

>S`W^VS`OZ >ObVeOg

AS`]b]\W\

BVS P`WRUS

# 6B! @SQS^b]`a

µ 7 e]cZR \]e ZWYS b] aVO`S eWbV g]c V]e 5A9 Wa Q]\bW\cW\U b] QVO\US bVS ZWdSa ]T ^ObWS\ba `SQSWdW\U QVS[]bVS`O^g eWbV O \Se O\bWS[SbWQ bVS`O^g bVOb VSZ^a ^`SdS\b 17<D T]` # ROga eWbV Xcab O aW\UZS R]aS ¶

;=23@/B3:G 3;3B=53<71 163;=B63@/>G

bcRg 2SaWU\( 1]\b`]Z O`[a T`][ \Sc`]YW\W\ <9 O\bOU]\Wab abcRWSa O^`S^WbO\b O\R A QOa]^WbO\b >ObWS\ba `SQSWdSR [cZbWROg ]\RO\aSb`]\ O\R RSfO[SbVOa]\S T]` bVS ^`SdS\bW]\ ]T 17<D

/a STTSQbWdS Oa # 6B!a O`S bVSg QO\ ]\Zg bOYS 17<D ^`SdS\bW]\ a] TO`

AO[^ZS aOZSa [SaaOUS

17<D >`SdS\bW]\

# 6B # 6B!! @SQS^b]` @SQS^b]` /\bOU]\Wab /\bOU]\Wab

"

6756:G 3;3B=53<71 163;=B63@/>G

Â’ CaS bVS _cSabW]\a T]` Q]\aWRS`ObW]\ b] US\S`ObS RWaQcaaW]\ ]\ caS W\ P]bV VWUVZg O\R []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g ^ObWS\ba O\R USb O aS\aS ]T Qc``S\b ST¿QOQg ^S`QS^bW]\a

7<6707B 13<B@/: /<2 >3@7>63@/: A75</:7<5 7< 17<D

&

C<;3B <332 ;=/

''

µ 2Sa^WbS bVS eWRSa^`SOR caS ]T # 6B!a [O\g ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ O\R OZa] bV]aS `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g abWZZ acTTS` T`][ 17<D /a g]c QO\ aSS T`][ bVWa PO` U`O^V SdS\ eWbV H=4@/< O\R RSfO[SbVOa]\S c^ b] #& ]T ^ObWS\ba Sf^S`WS\QSR 17<D Rc`W\U bVS # ROga T]ZZ]eW\U SWbVS` VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g /a STTSQbWdS Oa # 6B!a O`S bVSg QO\ ]\Zg bOYS 17<D ^`SdS\bW]\ a] TO` ¶

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

>`]dWRS U`SObS` 17<D ^`SdS\bW]\ T]` g]c` ^ObWS\ba Â’ ;]`S ^ObWS\ba [Og U`SObZg PS\S¿b T`][ ORRW\U O\ <9 `SQS^b]` O\bOU]\Wab b] O # 6B! `SQS^b]` O\bOU]\Wab O\R RSfO[SbVOa]\S ^`]dWRW\U aWU\W¿QO\bZg VWUVS` 17<D ^`SdS\bW]\ ?C3AB7=<A 4=@ 1=<A723@/B7=<

Â’ 7\ g]c` ^`OQbWQS V]e ]TbS\ R] g]c aSS ^ObWS\ba ]\ VWUVZg Oa eSZZ Oa bV]aS ]\ []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g T]` eV][ O # 6B! `SQS^b]` O\bOU]\Wab O\R O Q]`bWQ]abS`]WR O`S \]b S\]cUV b] Q]\b`]Z 17<D-

Â’ 2] g]c caS O\ <9 `SQS^b]` O\bOU]\Wab W\ g]c` ^`OQbWQS- 7T a] T]` eVOb ^S`QS\bOUS ]T ^ObWS\ba R]Sa Wb ^`SdS\b 17<D-

BVS []ab Q][[]\Zg `S^]`bSR ORdS`aS SdS\ba W\ ^ObWS\ba `SQSWdW\U H=4@/< W\ QZW\WQOZ b`WOZa eS`S VSOROQVS # b] % RWO``VSO * b] $ Q]\abW^ObW]\ * b] ' TSdS` * b] & O\R [OZOWaS TObWUcS b] !

"

#

7[^]`bO\b TOQb Â’ BVS `O\US ]T ^ObWS\ba abWZZ Sf^S`WS\QW\U 17<D W\ bVS PO` U`O^V Q][Sa T`][ bVS # ROg TOWZc`S \c[PS`a ]T bVS Q]\b`]Z O`[a W\ bVS O^`S^WbO\b O\R @3H=<71 QZW\WQOZ b`WOZa BVSaS abcRWSa eS`S caSR PSQOcaS abcRWSa ]T ]ZRS` # 6B!a RWR \]b SfO[W\S 17<D ]dS` # ROga bg^WQOZZg OQcbS( ROg ]` ROga b] !

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


>/53 $

>/53 %

6756:G 3;3B=53<71 163;=B63@/>G

6756:G 3;3B=53<71 163;=B63@/>G

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] aV]e VSOZbV QO`S ^`]dWRS`a bVOb @3H=<71 ]TTS`a aWU\W¿QO\bZg W[^`]dSR 17<D ^`SdS\bW]\ W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g Q][^O`SR eWbV O # 6B! O\R RSfO[SbVOa]\S OZ]\S

AO[^ZS aOZSa [SaaOUS

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

µ :Sb [S aVO`S W\ U`SObS` RSbOWZ W\T]`[ObW]\ OP]cb AW\UZS =`OZ 2]aS @3H=<71 O \Se T]`QS T]` # ROg 17<D ^`SdS\bW]\ W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g /a g]c QO\ aSS bVS @3H=<71 `SUW[S\ ^`]dWRSR O abObWabWQOZZg aWU\W¿QO\b PS\S¿b T]` P]bV OQcbS O\R RSZOgSR 17<D 7\ TOQb &$ ]T ^ObWS\ba VOR \] d][WbW\U \] `SbQVW\U O\R `S_cW`SR \] caS ]T `SaQcS [SRWQObW]\ T]` # ROga W\ QgQZS ¶

µ BVS VWUV ST¿QOQg `ObS eOa acabOW\SR ]dS` [cZbW^ZS QgQZSa ¶

/A >/@B =4 /< /<B73;3B71 @357;3<

@3H=<71 4=@ # 2/G 17<D >@3D3<B7=< 7< 6756:G 3;3B=53<71 163;=B63@/>G

6WUV ST¿QOQg acabOW\SR ]dS` [cZbW^ZS VWUVZg S[Sb]US\WQ QVS[]bVS`O^g QgQZSa

&$ ]T ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g OQVWSdSR O Q][^ZSbS `Sa^]\aS T]` # TcZZ ROga eWbV bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ da $$ bOYW\U ]\RO\aSb`]\ O\R RSfO[SbVOa]\S OZ]\S Q]\b`]Z

2c`W\U OZZ acPaS_cS\b b`SOb[S\b QgQZSa bV`]cUV " []ab ^ObWS\ba [OW\bOW\SR O Q][^ZSbS `Sa^]\aS eWbV bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

6756:G 3;3B=53<71

&$ ´\] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g T]` # ROga QgQZS W\ O ZO`US ^VOaS ! QZW\WQOZ b`WOZ <+&

1=;>:3B3 @3A>=<A3 /1@=AA 6756:G 3;3B=53<71 163;=B63@/>G 1G1:3A " <= D=;7B7<5 @3B167<5 /<2 <= CA3 =4 @3A1C3 B63@/>G

1=;>:3B3 @3A>=<A3 >@7;/@G 3<2 >=7<B 4@=; 2/G B6@=C56 2/G # 7< 1G1:3 <= D=;7B7<5 @3B167<5 /<2 <= CA3 =4 @3A1C3 B63@/>G ]\RO\aSb`]\ RSfO[SbVOa]\S \+ $#

7[^]`bO\b TOQba

]\RO\aSb`]\ RSfO[SbVOa]\S

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S \+ $$

>/B73<BA

BVS ^`W[O`g S\R ^]W\b 1][^ZSbS @Sa^]\aS eOa RS¿\SR Oa <= d][WbW\U `SbQVW\U O\R <= caS ]T `SaQcS bVS`O^g ]dS` # ROga BVWa S\R ^]W\b RWR \]b W\QZcRS \OcaSO

$

&&

'#

'"

&

&$

$$

"

>/B73<BA

&$

&

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

$

'

%%

'!

%&

%"

\+ "$

\+ !

\+ &

\+'%

\+&'

\+%#

1G1:3

7\ [O`YSb `SaSO`QV bVSaS RObO eS`S VWUVZg W[^OQbTcZ´]c` Qcab][S`a PSZWSdSR bVOb bVS ST¿QOQg ]T @3H=<71 eOa eWbV]cb R]cPb U`SObS` bVO\ bVOb ]T O # 6B! O\R Q]`bWQ]abS`]WR OZ]\S O\R [O\g PSZWSdSR Wb b] PS VWUVS` bVO\ bVS ST¿QOQg \c[PS`a T]` 3[S\R Oa eSZZ

=D3@/::

2/G

2/GA #

>*

>+ ""

>*

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ ^`W[O`WZg Zc\U QO\QS` ^ObWS\ba <+& `SQSWdW\U QWa^ZObW\ POaSR QVS[]bVS`O^g >ObWS\ba eS`S OR[W\WabS`SR AW\UZS =`OZ 2]aS @3H=<71 ]\ ROg ]\RO\aSb`]\ ]\ ROg O\R RSfO[SbVOa]\S ]\ ROga b] "

1G1:3 !

BVS ^ObWS\b QOaS abcRWSa ]\ SOQV a^`SOR QO\ VSZ^ g]c ^OW\b bVS ^WQbc`S ]T bVS ^ObWS\b T]` eV][ VSOZbV QO`S ^`]TSaaW]\OZa aV]cZR PS ^`SaQ`WPW\U @3H=<71

1G1:3 "

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ ^`W[O`WZg Zc\U QO\QS` ^ObWS\ba <+& `SQSWdW\U QWa^ZObW\ POaSR QVS[]bVS`O^g >ObWS\ba eS`S OR[W\WabS`SR AW\UZS =`OZ 2]aS @3H=<71 ]\ ROg ]\RO\aSb`]\ ]\ ROg O\R RSfO[SbVOa]\S ]\ ROga b] "

>=B3<B7/: 17<D >/B73<B ´17<D @7A9

' ^ObWS\ba VOR \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g T]` # TcZZ ROga

AbS^VO\WS( "# gSO`a ]ZR []bVS` ]T ^O`b bW[S PO\Y bSZZS` \]\ a[OZZ QSZZ Zc\U QO\QS` 1VS[]bVS`O^g( VWUVZg S[Sb]US\WQ QWa^ZObW\ O\R R]QSbOfSZ /\bWS[SbWQ bVS`O^g( AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

BVS bSOZ P]f Ob bVS P]bb][ ]T SOQV a^`SOR Wa W\bS\RSR b] `SW\T]`QS V]e @3H=<71 Wa UWdS\ Oa ^O`b ]T O `SUW[S\

>6GA717/< 7<A756B 9\]eW\U bVOb O `SUW[S\ Q]\bOW\W\U QWa^ZObW\ O\R R]QSbOfSZ QO\ PS _cWbS S[Sb]US\WQ T`][ QgQZS bVWa ^ObWS\b \SSRa bVS 17<D ^`SdS\bW]\ ]T bVS @3H=<71 @SUW[S\

<3E 4@=; 5:/F=A;7B69:7<3´;/93@ =4 H=4@/< @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa

AO[^ZS aOZSa [SaaOUS µ EVOb bVWa [SO\a Wa bVOb Pg caW\U AW\UZS =`OZ 2]aS @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQa g]c eWZZ ^`]dWRS aWU\W¿QO\b 17<D ^`SdS\bW]\ T]` ' ]T ^ObWS\ba ]dS` # TcZZ ROga ¶

µ @]PS`b Wa O ^ObWS\b ZWYS bV]aS g]c [Og aSS W\ g]c` ^`OQbWQS 6S VOa \]\ a[OZZ QSZZ Zc\U QO\QS` T]` eVWQV VS eWZZ `SQSWdS QO`P]^ZObW\ O\R bOf]Z O VWUVZg S[Sb]US\WQ `SUW[S\ 4`][ bVS PSUW\\W\U ]T VWa QVS[]bVS`O^g bVWa ^ObWS\b `SOZZg \SSRa bVS 17<D ^`SdS\bW]\ bVOb QO\ PS OQVWSdSR eWbV bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ ¶

7[^]`bO\b TOQba

AO[^ZS aOZSa [SaaOUS

@3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba 1V`]\WQ ROWZg caS ]T @3H=<71 Wa \]b `SQ][[S\RSR BVS QV`]\WQ ROWZg caS ]T @3H=<71 T]` ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U VOa \]b PSS\ abcRWSR O\R [Og OZbS` R`cU W\bS`OQbW]\ ^`]¿ZSa 1][^ZSbS `Sa^]\aS eOa RS¿\SR Oa \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS [SRWQObW]\ T`][ ROga bV`]cUV # b] V]c`a 6g^]bVSbWQOZ ^ObWS\b ^`]¿ZS <]b OQbcOZ ^ObWS\b ]` ^VgaWQWO\

BVS P`WRUS

BVS @3H=<71 @SUW[S\ ´ # TcZZ ROga ]T 17<D ^`SdS\bW]\ eWbV O aW\UZS <9 R]aS AW\UZS =`OZ 2]aS @3H=<71 ORRSR b] ]\RO\aSb`]\ O\R [cZbWROg RSfO[SbVOa]\S ^`SdS\ba 17<D T]` # ROga W\ ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

>ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

NEW

$

%

µ G]c O`S ^`]POPZg []ab OQQcab][SR b] caW\U O\ <9 eWbV VWUVZg S[Sb]US\WQ QVS[]bVS`O^g Pcb eVOb OP]cb bVS [O\g ^ObWS\ba eV] Q]\bW\cS b] acTTS` ]\ []RS`ObSZg S[Sb]US\WQ `SUW[S\a- 7¸R ZWYS b] aV]e g]c V]e @3H=<71 QO\ VSZ^ bV]aS ^ObWS\ba Oa eSZZ ¶

7[^]`bO\b TOQb BVS ZO\UcOUS µ' ]T ^ObWS\ba¶ VSZ^a b] P`W\U bVS RObO b] ZWTS O\R OZZ]ea bVS Qcab][S` b] S\dWaW]\ VWa ]` VS` ^ObWS\b ^]^cZObW]\ 8cab bVW\Y eWbV @3H=<71 ORRWbW]\OZ ^ObWS\ba ]T SdS`g Q]cZR PS T`SS T`][ d][WbW\U `SbQVW\U O\R caS ]T `SaQcS bVS`O^g T]` # TcZZ ROga

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4>= >


>/53 &

>/53 '

;=23@/B3:G 3;3B=53<71 163;=B63@/>G

;=23@/B3:G 3;3B=53<71 163;=B63@/>G

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] Q]\dW\QS VSOZbV ^`]TSaaW]\OZa bVOb @3H=<71 ]TTS`a aWU\W¿QO\bZg W[^`]dSR 17<D ^`SdS\bW]\ W\ []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g Q][^O`SR eWbV O # 6B! O\R RSfO[SbVOa]\S OZ]\S O\R b] SZSdObS bVS caS ]T @3H=<71 W\ bVS []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g ^]^cZObW]\

AO[^ZS aOZSa [SaaOUS

µ BVWa VWUV ST¿QOQg `ObS eOa acabOW\SR ]dS` [cZbW^ZS QgQZSa Oa aV]e\ W\ bVWa QVO`b ¶

/A >/@B =4 /< /<B73;3B71 @357;3<

@3H=<71 4=@ # 2/G 17<D >@3D3<B7=< 7< ;=23@/B3:G 3;3B=53<71 163;=B63@/>G

%! ´\] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g T]` # ROga QgQZS W\ bVS ZO`USab []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g b`WOZ b] RObS <+ '!!

6WUV `Sa^]\aS acabOW\SR bV`]cUV [cZbW^ZS []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g QgQZSa

AO[^ZS aOZSa [SaaOUS

%! ]T ^ObWS\ba `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g OQVWSdSR O Q][^ZSbS `Sa^]\aS T]` # TcZZ ROga eWbV bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ da #' eWbV Q]\b`]Z

2c`W\U acPaS_cS\b QgQZSa bV`]cUV " []ab ^ObWS\ba [OW\bOW\SR O Q][^ZSbS `Sa^]\aS eWbV bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

µ 2] g]c aSS ^ObWS\ba ZWYS ASZS\O W\ g]c` ^`OQbWQS¬g]c\U e][S\ eWbV P`SOab QO\QS` eV] O`S Ob ^O`bWQcZO` `WaY ]T Sf^S`WS\QW\U 17<D- BVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ QO\ VSZ^ bVSaS ^ObWS\ba `S[OW\ T`SS T`][ S[SaWa SdS\ OTbS` bVSg U] V][S ]\ bVS ROga T]ZZ]eW\U QVS[]bVS`O^g ¶

1=;>:3B3 @3A>=<A3 >@7;/@G 3<2 >=7<B 4@=; 2/G B6@=C56 2/G # 7< 1G1:3 <= D=;7B7<5 @3B167<5 /<2 <= CA3 =4 @3A1C3 B63@/>G

<= D=;7B7<5 @3B167<5 /<2 <= CA3 =4 @3A1C3 B63@/>G

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S \+"%'

]\RO\aSb`]\ RSfO[SbVOa]\S

>/B73<BA

&

/a W\ bVS VWUVZg S[Sb]US\WQ QVS[]bVS`O^g b`WOZ bVS ^`W[O`g S\R ^]W\b 1][^ZSbS @Sa^]\aS eOa RS¿\SR Oa <= d][WbW\U `SbQVW\U O\R <= caS ]T `SaQcS bVS`O^g ]dS` # ROga BVWa S\R ^]W\b RWR \]b W\QZcRS \OcaSO

%!

&#

&&

%!

$

#' "

&

>/B73<BA

7[^]`bO\b TOQba

$

&

&

%'

$'

$%

$!

7[^]`bO\b TOQb

\+!%%

\+!&!

\+!!!

\+!"#

\+ &'

;O\g []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g `SUW[S\a O`S []`S S[Sb]US\WQ bVO\ Qcab][S`a PSZWSdS O\R bVS`ST]`S ^ObWS\ba O`S abWZZ acTTS`W\U =\ bVS 6SaYSbV aQOZS O\ /1 QgQZ]^V]a^VO[WRS O\R O bOfO\S `SUW[S\ Wa Q]\aWRS`SR VWUVZg S[Sb]US\WQ 1]\dW\QW\U Qcab][S`a ]T bVWa O\R bVOb ^ObWS\ba \SSR bVS ORRWbWdS ^`SdS\bW]\ ]T @3H=<71 Wa W[^S`ObWdS$

\+! $

=D3@/::

2/G

2/GA #

>*

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ P`SOab QO\QS` ^ObWS\ba <+ '!! `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g >ObWS\ba eS`S OR[W\WabS`SR AW\UZS =`OZ 2]aS @3H=<71 ]\ ROg ]\RO\aSb`]\ ]\ ROga b] ! O\R RSfO[SbVOa]\S ]\ ROg

7\ [O`YSb `SaSO`QV bVSaS RObO eS`S ZSaa Q][^SZZW\U bVO\ bVS VWUVZg S[Sb]US\WQ RObO´V]eSdS` Qcab][S`a RWR aSS bVWa Oa PSW\U O ac^S`W]` `SUW[S\ b] O # 6B! O\R Q]`bWQ]abS`]WR OZ]\S

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

;=23@/B3:G 3;3B=53<71

]\RO\aSb`]\ RSfO[SbVOa]\S \+"%'

1=;>:3B3 @3A>=<A3 /1@=AA ;=23@/B3:G 3;3B=53<71 163;=B63@/>G 1G1:3A "

@SOaac`S Qcab][S`a bVOb bVS []RS`ObS \c[PS`a O`S Z]eS` ^]aaWPZg RcS b] bVS dS`g ZO`US \c[PS` ]T TS[OZS ^OWS\ba W\ bVS b`WOZ Wb Wa PSZWSdSR bVOb 17<D W\ e][S\ [Og PS []`S RWT¿QcZb b] ^`SdS\b O\R bVOb ^ObWS\ba RWR \]b `SQSWdS RSfO[SbVOa]\S ]\ ROga O\R ! Oa W\ bVS VWUVZg S[Sb]US\WQQVS[]bVS`O^g b`WOZ

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

µ AW\UZS =`OZ 2]aS @3H=<71 Wa O \Se T]`QS T]` # ROg 17<D ^`SdS\bW]\ T]` bVS [O\g ^ObWS\ba `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g eV] Q]\bW\cS b] acTTS` =dS`OZZ %! ]T ^ObWS\ba Sf^S`WS\QSR \] d][WbW\U \] `SbQVW\U O\R `S_cW`SR \] `SaQcS [SRWQObW]\ T]` # ROga W\ QgQZS EVWZS bVSaS `SacZba O`S abObWabWQOZZg aWU\W¿QO\b bVS `SOZ PS\S¿b ]T bVS @3H=<71 @SUW[S\ QO\ PS aSS\ W\ ROga bV`]cUV # ¶

1G1:3

1G1:3 "

1G1:3 !

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ P`SOab QO\QS` ^ObWS\ba <+ '!! `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g >ObWS\ba eS`S OR[W\WabS`SR AW\UZS =`OZ 2]aS @3H=<71 ]\ ROg ]\RO\aSb`]\ ]\ ROga b] ! O\R RSfO[SbVOa]\S ]\ ROg

>=B3<B7/: 17<D >/B73<B ´;C:B7>:3 @7A9 4/1B=@A

% ^ObWS\ba VOR \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g T]` # TcZZ ROga

8O\Sb( "! gSO`a ]ZR `SQS\bZg RWd]`QSR ZOegS` P`SOab QO\QS` 1VS[]bVS`O^g( []RS`ObSZg S[Sb]US\WQ /1 R]f]`cPWQW\ QgQZ]^V]a^VO[WRS /\bWS[SbWQ bVS`O^g( AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

>6GA717/< 7<A756B 1 7<D Wa OZeOga O Q]\QS`\ Sa^SQWOZZg W\ g]c\U e][S\ /RRW\U @3H=<71 Wa O aW[^ZS STTSQbWdS eOg ]T S\ac`W\U bVSg VOdS bVS ^]eS`TcZ 17<D ^`SdS\bW]\ ]\QS bVSg U] V][S

<3E 4@=; 5:/F=A;7B69:7<3´;/93@ =4 H=4@/< @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^WSa @3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba

BVS @3H=<71 @SUW[S\ ´ # TcZZ ROga ]T 17<D ^`SdS\bW]\ eWbV O aW\UZS <9 R]aS

BVS P`WRUS

AW\UZS =`OZ 2]aS @3H=<71 ORRSR b] [cZbWROg ]\RO\aSb`]\ O\R RSfO[SbVOa]\S ^`SdS\ba 17<D T]` # ROga W\ ^ObWS\ba `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

µ <]e bVOb g]c VOdS O\ c\RS`abO\RW\U ]T bVS ^]eS`TcZ 17<D ^`SdS\bW]\ OQVWSdSR eWbV AW\UZS =`OZ 2]aS @3H=<71 7¸R ZWYS b] aVO`S eWbV g]c eVOb bVWa QO\ [SO\ T]` g]c` ^ObWS\ba ¶

1V`]\WQ ROWZg caS ]T @3H=<71 Wa \]b `SQ][[S\RSR BVS QV`]\WQ ROWZg caS ]T @3H=<71 T]` ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U VOa \]b PSS\ abcRWSR O\R [Og OZbS` R`cU W\bS`OQbW]\ ^`]¿ZSa 1][^ZSbS `Sa^]\aS eOa RS¿\SR Oa \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS [SRWQObW]\ T`][ ROga bV`]cUV # b] V]c`a 6g^]bVSbWQOZ ^ObWS\b ^`]¿ZS <]b OQbcOZ ^ObWS\b ]` ^VgaWQWO\

>ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

NEW

&

'

AO[^ZS aOZSa [SaaOUS µ EVOb bVWa [SO\a Wa bVOb Pg caW\U AW\UZS =`OZ 2]aS @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQa g]c eWZZ ^`]dWRS aWU\W¿QO\b # ROg 17<D ^`SdS\bW]\ T]` % ]T ]` []`S ]T SdS`g ^ObWS\ba Q][^O`SR eWbV O # 6B! O\R RSfO[SbVOa]\S OZ]\S ¶

7[^]`bO\b TOQb G]c` Qcab][S`a Q]cZR aSS O\ ORRWbW]\OZ ]T SdS`g ^ObWS\ba OQVWSdW\U aWU\W¿QO\b PS\S¿ba T`][ @3H=<71 eWbV \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g T]` # TcZZ ROga T]ZZ]eW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g 4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


>/53

>/53

4C<1B7=</: :7D7<5 7<23F³3;3A7A 4:73

4C<1B7=</: :7D7<5 7<23F³3;3A7A 4:73

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] RS[]\ab`ObS V]e ORRW\U AW\UZS =`OZ 2]aS @3H=<71 [Og SZW[W\ObS bVS W[^OQb ]T 17<D ]\ ^ObWS\ba¸ SdS`gROg ZWdW\U

AO[^ZS aOZSa [SaaOUS @3H=<71 63:>A 17<D >/B73<BA @3137D7<5 6756:G 3;3B=53<71 163;=B63@/>G ;/7<B/7< B637@ 2/7:G 4C<1B7=</: :7D7<5

7[^]`bO\b TOQba

%% ]T ^ObWS\ba ]\ bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ `S^]`bSR \] W[^OQb ]T \OcaSO O\R d][WbW\U ]\ bVSW` ROWZg ZWdSa T]` # TcZZ ROga eVWZS `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g da $" eWbV Q]\b`]Z

µ EVS\ 17<D Wa ^`SdS\bSR eWbV AW\UZS =`OZ 2]aS @3H=<71 ^ObWS\ba eS`S OPZS b] R] []`S ZWYS S\X]g O `SQ`SObW]\OZ OQbWdWbg Q]]Y SOb R`W\Y ÀcWRa O\R a^S\R bW[S eWbV TO[WZg O\R T`WS\Ra ¶

/A >/@B =4 /< /<B73;3B71 @357;3<

>ObWS\ba QO\ R] aWU\W¿QO\bZg []`S eVS\ 17<D Wa ^`SdS\bSR " %% ´\] W[^OQb ]T 17<D ]\ ROWZg ZWdSa T]` # TcZZ ROga W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

7\ [O`YSb `SaSO`QV bVSaS RObO eS`S ]T ^O`bWQcZO` W[^]`bO\QS b] ]\Q]Z]Ug \c`aSa

@SQ`SObW]\ ]` ZSWac`S OQbWdWbg

;OYS [SOZa R] bOaYa

/PWZWbg b] S\X]g [SOZ

3\X]g R`W\YW\U ÀcWRa

ASS TO[WZg T`WS\Ra

2OWZg Tc\QbW]\W\U

EWbV]cb ^S`a]\OZ VO`RaVW^

EWbV]cb VO`RaVW^ ]\ ]bVS`a

AO[^ZS aOZSa [SaaOUS

<= 7;>/1B =4 17<D =< 2/7:G :7D3A 4@=; 2/G B6@=C56 2/G # 7< 1G1:3

]\RO\aSb`]\ RSfO[SbVOa]\S

BVS W[^OQb ]T \OcaSO O\R d][WbW\U ]\ ROWZg ZWTS eOa SdOZcObSR caW\U 4c\QbW]\OZ :WdW\U 7\RSf´3[SaWa 4:73 O\ & WbS[ 42/ dOZWRObSR ^ObWS\b `S^]`bSR _cSabW]\\OW`S

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

B VS W[^OQb ]T \OcaSO O\R d][WbW\U ]\ ROWZg ZWTS eOa SdOZcObSR caW\U 4:73 4c\QbW]\OZ :WdW\U 7\RSf´3[SaWa O\ & WbS[ dOZWRObSR ^ObWS\b `S^]`bSR _cSabW]\\OW`S

$

´ 1 ][^O`Wa]\ ]T 4:73 WbS[ aQ]`Sa Ob POaSZW\S O\R Ob ROg $ aV]eSR aWU\W¿QO\b RWTTS`S\QSa

$"

>* # TOd]`W\U bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\"

"

%& ´\] aWU\W¿QO\b \OcaSO T]` # ROga W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

\+ $#

\+ $$

6756:G 3;3B=53<71 163;=B63@/>G >* #

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ ^`W[O`WZg Zc\U QO\QS` ^ObWS\ba <+& `SQSWdW\U QWa^ZObW\ POaSR QVS[]bVS`O^g >ObWS\ba eS`S OR[W\WabS`SR AW\UZS =`OZ 2]aS @3H=<71 ]\ ROg ]\RO\aSb`]\ ]\ ROg O\R RSfO[SbVOa]\S ]\ ROga b] "

BVS ROg $ b]bOZ 4:73 aQ]`S \OcaSO 4:73 R][OW\ aQ]`S O\R d][WbW\U 4:73 R][OW\ aQ]`S eS`S bSabSR caW\U O EWZQ]f]\ `O\Y ac[ bSab T]` RWTTS`S\QSa W\ RWab`WPcbW]\a PSbeSS\ bVS Q]\b`]Z O\R SOQV QOa]^WbO\b b`SOb[S\b U`]c^

2/7:G 4C<1B7=</: :7D7<5

>/B73<BA

&

>ObWS\ba Q][^ZSbSR bVS 4:73 _cSabW]\\OW`S Ob POaSZW\S ^`W]` b] `SQSWdW\U QVS[]bVS`O^g O\R ]\ ROg $ OTbS` Q][^ZSbW]\ ]T bVS ¿`ab QgQZS ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^g O\R caS ]T bVS abcRg R`cU

& ]cb ]T ^ObWS\ba [OW\bOW\SR Tc\QbW]\OZ ZWdW\U

µ EVWZS g]c QO\ OQVWSdS VWUV ST¿QOQg `SacZba bVOb `SRcQS bVS W[^OQb ]T 17<D ]\ ^ObWS\ba¸ ZWdSa eWbV AW\UZS =`OZ 2]aS @3H=<71 W\ Q][PW\ObW]\ eWbV O # 6B! O\R RSfO[SbVOa]\S g]c [Og VOdS ^ObWS\ba T]` eV][ O\ 7D `SUW[S\ e]cZR PS []`S O^^`]^`WObS ¶

>=B3<B7/: 17<D >/B73<B ´17<D 0C@23<

@]PS`b( $ gSO`a ]ZR [O``WSR b`cQY R`WdS` \]\ a[OZZ QSZZ Zc\U QO\QS` 1VS[]bVS`O^g( VWUVZg S[Sb]US\WQ QWa^ZObW\ US[QWbOPW\S /\bWS[SbWQ bVS`O^g( AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

@3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa

>6GA717/< 7<A756B 7b Wa W[^]`bO\b T]` ^ObWS\ba ZWYS @]PS`b bVOb 17<D R]Sa \]b PSQ][S O VcUS Pc`RS\ EWbV @3H=<71 17<D RWR \]b W[^OQb VWa OPWZWbg b] Tc\QbW]\

<3E 4@=; 5:/F=A;7B69:7<3´;/93@ =4 H=4@/<

AW\UZS =`OZ 2]aS @3H=<71 ORRSR b] ]\RO\aSb`]\ O\R [cZbWROg RSfO[SbVOa]\S ^`SdS\ba 17<D T]` # ROga W\ ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

@3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba ASZSQb WbS[a T`][ ]`WUW\OZ ZWab ]T ' 4:73 Q`WbS`WO 6g^]bVSbWQOZ ^ObWS\b ^`]¿ZS <]b OQbcOZ ^ObWS\b ]` ^VgaWQWO\

>ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

NEW

AO[^ZS aOZSa [SaaOUS µ & ]T ^ObWS\ba [OW\bOW\SR Tc\QbW]\OZ ZWdW\U eVWQV [SO\a bVOb bVS ROWZg ZWTS ]T []`S ^ObWS\b ]cb ]T SdS`g eWZZ \]b PS W[^OQbSR Pg 17<D ¶

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

µ 4]` Zc\U QO\QS` ^ObWS\ba ZWYS AbS^VO\WS [OW\bOW\W\U ROWZg Tc\QbW]\OZ ZWdW\U Pg ^`SdS\bW\U 17<D Wa ]T ^O`bWQcZO` W[^]`bO\QS >`]dWRW\U bVS[ eWbV bVS ^]bS\b ST¿QOQg ]T AW\UZS =`OZ 2]aS @3H=<71 QO\ VSZ^ SZW[W\ObS bVS W[^OQb ]T 17<D ]\ bVSW` ROWZg ZWdSa ¶

BVS P`WRUS

%& ]T ^ObWS\ba ]\ bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ RWR \]b VOdS aWU\W¿QO\b \OcaSO T]` # TcZZ ROga da $' eWbV Q]\b`]Z >+ %

BVS @3H=<71 @SUW[S\ ´# ROg 17<D ^`SdS\bW]\ bVOb VSZ^a ^`SaS`dS ^ObWS\ba ROWZg Tc\QbW]\OZ ZWdW\U

/ b]bOZ 4:73 aQ]`S , & eOa QObSU]`WhSR Oa \] W[^OQb ]\ ROWZg ZWTS <72: T]` \OcaSO O\R d][WbW\U BVSaS RObO O`S T`][ bVS VWUVZg S[Sb]US\WQ QVS[]bVS`O^g b`WOZ ]\Zg

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

µ 0Sg]\R VWUV ST¿QOQg `SacZba Wb Wa W[^]`bO\b T]` g]c b] Y\]e bVOb eVWZS ]\ O `SUW[S\ W\QZcRW\U AW\UZS =`OZ 2]aS @3H=<71 %% ]T ^ObWS\ba `S^]`bSR \] W[^OQb ]T 17<D ]\ bVSW` ROWZg ZWdSa T]` # TcZZ ROga BVSaS `SacZba eS`S abObWabWQOZZg aWU\W¿QO\b ¶


>/53

>/53 !

! 2/G 7D =@/:

! 2/G 7D =@/:

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa aV]e bVS ^]eS`TcZ ST¿QOQg ]T bVS ]bVS` R]aW\U ]^bW]\ T]` @3H=<71´7D ]\ ROg T]ZZ]eSR Pg ]`OZ ]\ ROga O\R ! 7D =`OZ =`OZ

AO[^ZS aOZSa [SaaOUS

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

µ @3H=<71 ]TTS`a ÀSfWPZS R]aW\U ]^bW]\a 7\ ORRWbW]\ b] bVS AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ g]c QO\ QV]]aS b] OR[W\WabS` 7D @3H=<71 ]\ ROg T]ZZ]eSR Pg ]`OZ R]aSa ]\ ROga O\R ! ¶

µ AW[WZO`Zg Ob ZSOab %" ]T ^ObWS\ba Sf^S`WS\QSR \] d][WbW\U \] `SbQVW\U O\R `S_cW`SR \] caS ]T `SaQcS bVS`O^g T]` # TcZZ ROga Rc`W\U [cZbW^ZS []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g QgQZSa ¶

/A >/@B =4 /< /<B73;3B71 @357;3<

@3H=<71 4=@ # 2/G 17<D >@3D3<B7=< =443@A B63 4:3F707:7BG =4 /< 7D @357;3<

BVS ! 2Og 7D =`OZ @3H=<71 @SUW[S\ OQVWSdSR O\R [OW\bOW\SR VWUV ST¿QOQg `ObSa W\ ^ObWS\ba ]\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

BVS ! 2Og 7D =`OZ @3H=<71 @SUW[S\ OQVWSdSR O\R [OW\bOW\SR VWUV ST¿QOQg `ObSa W\ ^ObWS\ba ]\ []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

& ]T ^ObWS\ba OQVWSdSR Q][^ZSbS `Sa^]\aS T]` # TcZZ ROga W\ QgQZS eWbV bVS ! 2Og 7D =`OZ @3H=<71 @SUW[S\ da $$ eWbV Q]\b`]Z

%" ]T ^ObWS\ba OQVWSdSR Q][^ZSbS `Sa^]\aS T]` # TcZZ ROga W\ QgQZS eWbV bVS ! 2Og 7D =`OZ @3H=<71 @SUW[S\ da #' eWbV Q]\b`]Z

1=;>:3B3 @3A>=<A3 4@=; 2/G B6@=C56 2/G # 7< 6756:G 3;3B=53<71 163;=B63@/>G´1G1:3 /<2 1G1:3A B= " "

AO[^ZS aOZSa [SaaOUS µ BVS 7D =`OZ =`OZ @SUW[S\ OQVWSdSR VWUV ST¿QOQg `ObSa W\ P]bV QZW\WQOZ b`WOZa & ]T ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g RWR \]b Sf^S`WS\QS d][WbW\U ]` `SbQVW\U O\R RWR \]b `S_cW`S `SaQcS bVS`O^g T]` # TcZZ ROga BVWa STTSQb eOa [OW\bOW\SR OQ`]aa " QVS[]bVS`O^g QgQZSa ¶

]\RO\aSb`]\ RSfO[SbVOa]\S

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

<= D=;7B7<5 @3B167<5 /<2 <= CA3 =4 @3A1C3 B63@/>G

! 2Og 7D =`OZ @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

]\RO\aSb`]\ RSfO[SbVOa]\S

&$ (P<0.0001)

&

&' %%

%&

&%

&& %%

(P=0.0004)

$$

"

&

>/B73<BA

>/B73<BA

AW\UZS =`OZ 2]aS @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

µ A] T]` ^ObWS\ba ZWYS 8OgZW\ T]` eV][ O\ 7D `SUW[S\ e]cZR PS ^`STS``SR g]c QO\ ^`SaQ`WPS bVS 7D =`OZ =`OZ @3H=<71 @SUW [S\ ¶

! 2Og 7D =`OZ @3H=<71 ]\RO\aSb`]\ RSfO[SbVOa]\S

&

$

AO[^ZS aOZSa [SaaOUS

1=;>:3B3 @3A>=<A3 4@=; 2/G B6@=C56 2/G # 7< ;=23@/B3:G 3;3B=53<71 163;=B63@/>G´1G1:3 /<2 1G1:3A B= " "

<= D=;7B7<5 @3B167<5 /<2 <= CA3 =4 @3A1C3 B63@/>G

%! %"

$

#'

(P<0.0001)

\+"%'

\+"%'

&

(P=0.0001)

$!

\+"%'

\+!%%

&"

&

$'

$%

7[^]`bO\b TOQb

\+ $#

\+ $$

\+ $'

\+ "$

\+ $

\+ &

\+

\+&'

\+%$

\+!!!

\+!"!

\+ &'

\+! "

1G1:3

1G1:3

1G1:3 !

1G1:3 "

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ ^`W[O`WZg Zc\U QO\QS` ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g <+& >ObWS\ba eS`S OR[W\WabS`SR aW\UZS ]`OZ R]aS ]` ! ROg 7D ]`OZ @3H=<71 ]\ ROg ]` ROga b] ! ]\RO\aSb`]\ ]\ ROg O\R RSfO[SbVOa]\S ]\ ROga b] "

7[^]`bO\b TOQba

\+!%

1G1:3

1G1:3 !

1G1:3 "

! 2/G 7D =@/: @357;3<

4]` a][S ^ObWS\ba O\ 7D `SUW[S\ Wa ^`STS``SR 1cab][S`a QO\ TSSZ Q]\¿RS\b bVSg eWZZ OQVWSdS bVS aO[S ZSdSZ ]T 17<D ^`SdS\bW]\ eWbV bVS 7D =`OZ =`OZ @SUW[S\ bVOb QO\ PS OQVWSdSR eWbV bVS AW\UZS =`OZ 2]aS @SUW[S\

1G1:3

AbcRg 2SaWU\( @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRg W\ P`SOab QO\QS` ^ObWS\ba `SQSWdW\U []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g <+ '!! >ObWS\ba eS`S OR[W\WabS`SR aW\UZS ]`OZ R]aS ]` ! ROg 7D ]`OZ @3H=<71 ]\ ROg ]` ROga b] ! ]\RO\aSb`]\ ]\ ROga b] ! O\R RSfO[SbVOa]\S ]\ ROg

>=B3<B7/: 17<D >/B73<B ´;C:B7>:3 B@3/B;3<B 4/1B=@A

BVS`SaO( # gSO`a ]ZR bSOQVS` P`SOab QO\QS` 1VS[]bVS`O^g( []RS`ObSZg S[Sb]US\WQ R]f]`cPWQW\ QgQZ]^V]a^VO[WRS /\bWS[SbWQ bVS`O^g( ! 2Og 7D =`OZ @3H=<71 @SUW[S\

BVS ^`W[O`g S\R ^]W\b 1][^ZSbS @Sa^]\aS eOa RS¿\SR Oa <= d][WbW\U `SbQVW\U O\R <= caS ]T `SaQcS bVS`O^g ]dS` # ROga BVWa S\R ^]W\b RWR \]b W\QZcRS \OcaSO

>6GA717/< 7<A756B BVS`S O`S a] [O\g TOQb]`a bVOb U] W\b] b`SObW\U O ^ObWS\b ZWYS BVS`SaO´T`][ OQQSaa b] Q][^ZWO\QS @3H=<71 OZZ]ea [S b] bOWZ]` BVS`SaO¸a O\bWS[SbWQ b`SOb[S\b b] VS` \SSRa

7\TcaW]\ aWbS bV`][P]^VZSPWbWa eOa `S^]`bSR W\ bVS VWUVZg S[Sb]US\WQ QVS[]bVS`O^g abcRg T]` QgQZS O\R W\TcaW]\ aWbS ^OW\ W\TcaW]\ aWbS `SOQbW]\ S`gbVS[O ]` bV`][P]^VZSPWbWa eS`S `S^]`bSR W\ bVS []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g abcRg T]` QgQZS

<3E 4@=; 5:/F=A;7B69:7<3´;/93@ =4 H=4@/<

@3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa O\R \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^WSa

! 2Og 7D =`OZ @3H=<71 ORRSR b] [cZbWROg ]\RO\aSb`]\ O\R RSfO[SbVOa]\S ^`SdS\ba 17<D T]` # ROga W\ ^ObWS\ba `SQSWdW\U VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

1][^ZSbS `Sa^]\aS eOa RS¿\SR Oa \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS [SRWQObW]\ T`][ ROga bV`]cUV # b] V]c`a 6g^]bVSbWQOZ ^ObWS\b ^`]¿ZS <]b OQbcOZ ^ObWS\b ]` ^VgaWQWO\

BVS P`WRUS

BVS @3H=<71 @SUW[S\ ´# 4cZZ 2Oga ]T 17<D >`SdS\bW]\

@3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba >ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

µ <]e bVOb g]c VOdS aSS\ bVS ST¿QOQg RObO T]` @3H=<71 7¸R ZWYS b] aVO`S eWbV g]c bVS R]aW\U `SUW[S\a caSR W\ bVS ^VOaS !

NEW

!

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

EVWZS a][S VSOZbV QO`S ^`]dWRS`a e]cZR ^`STS` caW\U O\ 7D `SUW[S\ ^`W[O`WZg T]` `SW[Pc`aS[S\b ^c`^]aSa a][S _cSabW]\SR eVg O ! ROg `SUW[S\ eOa `S_cW`SR AV]cZR g]c S\Q]c\bS` bVWa _cSabW]\ W\ bVS ¿SZR g]c QO\ Sf^ZOW\ bVOb bVS b`WOZ eOa RSaWU\SR b] W\QZcRS bVS `SUW[S\a W\WbWOZZg Sf^SQbSR b] ^`]dWRS bVS U`SObSab O\bWS[SbWQ ST¿QOQg ]dS` bVS # ROga T]ZZ]eW\U QVS[]bVS`O^g


>/53 "

>/53 #

/2;7<7AB@/B7=<

/2;7<7AB@/B7=<

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] QZSO`Zg Q][[c\WQObS b] Qcab][S`a bVOb @3H=<71 aV]cZR PS OR[W\WabS`SR eWbV O # 6B! O\R O Q]`bWQ]abS`]WR 7b Wa c^ b] bVS ^VgaWQWO\¸a RWaQ`SbW]\ Oa b] eVWQV bVS`O^WSa O`S caSR O\R Ob eVOb R]aSa BVS bOPZSa aV]e V]e @3H=<71 eOa OR[W\WabS`SR W\ bVS ^VOaS ! QZW\WQOZ b`WOZa eVWQV eS`S POaSR ]\ bVS H=4@/< >7 O\R Q][^ZWSR eWbV 42/ O\R 3;3/ `SUcZObW]\a T]` b`WOZ RSaWU\

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION. / <3E 4=@13 4=@ >=B3<B # 2/G 17<D >@3D3<B7=< 7< 0=B6 =@/: /<2 7D 4=@;C:/B7=<A

µ @3H=<71 ]TTS`a ^]bS\b 17<D ^`SdS\bW]\ W\ P]bV ]`OZ O\R 7D T]`[cZObW]\a T]` # TcZZ ROga O\R eOa abcRWSR W\ [cZbW^ZS `SUW[S\a @3H=<71 aV]cZR PS OR[W\WabS`SR eWbV g]c` QV]WQS ]T O # 6B! O\R RSfO[SbVOa]\S ¶

AW\UZS =`OZ 2]aS O\R ! 2Og 7D =`OZ @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQa O`S W\RWQObSR b] ^`SdS\b 17<D W\ VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

/\bWS[SbWQ BVS`O^g

2Og

2Og

2Og !

BVS aWU\W¿QO\b O\bWS[SbWQ OQbWdWbg ]T AW\UZS =`OZ 2]aS @3H=<71 [Og PS RcS b] bVS VWUVZg ^]bS\b O\bOU]\Wa[ ]T bVS <9 `SQS^b]` eWbV ,' ]QQc^O\Qg ]dS` $ V]c`a" @O^WR ]\aSb( ]`OZ OPa]`^bW]\ [SRWO\ b[Of %# V]c`a :]\U Rc`ObW]\( Z]\U VOZT ZWTS # $ b] % V]c`a

2=A7<5 @357;3< 7< 6756:G 3;3B=53<71 163;=B63@/>G B@7/:

7[^]`bO\b TOQb

2Og "

G]c QO\ ^`SaQ`WPS @3H=<71 eWbV []`S Q]\¿RS\QS W\ ^ObWS\ba bOYW\U eO`TO`W\

AO[^ZS aOZSa [SaaOUS

@3H=<71 # [U ]`OZ AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

µ BVSaS bOPZSa RS[]\ab`ObS V]e @3H=<71 eOa OR[W\WabS`SR W\ ORRWbW]\ b] O # 6B! O\R RSfO[SbVOa]\S W\ VWUVZg O\R []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g b`WOZa BVSaS `SUW[S\a eS`S QV]aS\ POaSR ]\ bVS H=4@/< ZOPSZ O\R ]\ 42/ O\R 3;3/ `S_cW`S[S\ba T]` b`OWZ RSaWU\ 7\ ORRWbW]\ bVS RSfO[SbVOa]\S R]aSa eS`S `SRcQSR b] OQQ]c\b T]` QVO\USa W\ Sf^]ac`S eVS\ Q]OR[W\WabS`SR eWbV @3H=<71 ¶

! 2Og 7D =`OZ @3H=<71 @SUW[S\

H=4@/< ! [U 7D RSfO[SbVOa]\S [U ]`OZ @3H=<71 ' [U 7D H=4@/< ! [U 7D RSfO[SbVOa]\S [U ]`OZ ]\QS ROWZg

@3H=<71 R]Sa \]b W[^OQb bVS ^VO`[OQ]YW\SbWQa ]` ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\ BVWa Wa W[^]`bO\b PSQOcaS [O\g QO\QS` ^ObWS\ba O`S ]TbS\ bOYW\U O\bWQ]OUcZO\ba b] [W\W[WhS bVS `WaY ]T PZ]]R QZ]ba 1cab][S`a QO\ ^`SaQ`WPS @3H=<71 eWbV Q]\¿RS\QS W\ bVSaS ^O bWS\ba

1ZW\WQOZ ^VO`[OQ]Z]Ug abcRWSa VOdS RS[]\ab`ObSR bVOb QOa]^WbO\b R]Sa <=B VOdS O QZW\WQOZZg `SZSdO\b W[^OQb ]\ bVS ^VO`[OQ]YW\SbWQa ]` ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\ RSfO[SbVOa]\S & [U ]`OZ beWQS ROWZg

RSfO[SbVOa]\S & [U ]`OZ beWQS ROWZg

@3H=<71 # [U ]`OZ

@3H=<71 # [U ]`OZ

RSfO[SbVOa]\S & [U ]`OZ ]\QS ROWZg

RSfO[SbVOa]\S & [U ]`OZ ]\QS ROWZg

RSfO[SbVOa]\S & [U ]`OZ beWQS ROWZg

RSfO[SbVOa]\S & [U ]`OZ ]\QS ROWZg

>=B3<B7/: 17<D >/B73<B ´@3?C7@3A /<B71=/5C:/<B B63@/>G

2O\WSZ( $ gSO`a ]ZR `SbW`SR VSOR \SQY QO\QS` 1VS[]bVS`O^g( VWUVZg S[Sb]US\WQ QWa^ZObW\ # Àc]`]c`OQWZ /\bWS[SbWQ bVS`O^g( AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

>6GA717/< 7<A756B 2O\WSZ Wa Ob VWUV `WaY T]` PZ]]R QZ]ba O\R Wa ]\ O\bWQ]OUcZO\b bVS`O^g EWbV @3H=<71 7 QO\ ^`SdS\b VWa 17<D eWbV]cb Wb W[^OQbW\U bVS ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\

2=A7<5 @357;3< 7< ;=23@/B3:G 3;3B=53<71 163;=B63@/>G B@7/: /\bWS[SbWQ BVS`O^g

2Og

2Og

2Og !

RSfO[SbVOa]\S & [U 7D

H=4@/< & [U ]`OZ beWQS ROWZg

H=4@/< & [U ]`OZ beWQS ROWZg

@3H=<71 ' [U 7D

@3H=<71 # [U ]`OZ

@3H=<71 # [U ]`OZ

H=4@/< & [U ]`OZ beWQS ROWZg

H=4@/< & [U ]`OZ beWQS ROWZg

H=4@/< & [U ]`OZ beWQS ROWZg

RSfO[SbVOa]\S & [U 7D

2SfO[SbVOa]\S Wa ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ BVS`ST]`S bVS R]aS ]T RSfO[SbVOa]\S [Og \SSR b] PS `SRcQSR eVS\ Q]OR[W\WabS`SR eWbV @3H=<71

BVS @3H=<71 @SUW[S\ ´# TcZZ ROga ]T 17<D ^`SdS\bW]\ AW\UZS =`OZ 2]aS ]` ! 2Og 7D =`OZ @3H=<71 ORRSR b] [cZbWROg ]\RO\aSb`]\ O\R RSfO[SbVOa]\S ^`SdS\ba 17<D T]` # ROga W\ ^ObWS\ba `SQSWdW\U VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

/2;7<7AB@/B7=<

! 2Og 7D =`OZ @3H=<71 @SUW[S\

H=4@/< & [U ]`OZ beWQS ROWZg

BVS P`WRUS

<3E 4@=; 5:/F=A;7B69:7<3´;/93@ =4 H=4@/<

@3H=<71 # [U ]`OZ AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\

7[^]`bO\b TOQb

3dS\ eWbV Z]eS` R]aSa ]T RSfO[SbVOa]\S W\ P]bV ^VOaS 777 QZW\WQOZ b`WOZa @3H=<71 ^`]dWRSR U`SObS` 17<D ^`SdS\bW]\ T]` # TcZZ ROg Q][^O`SR eWbV H=4@/< O\R RSfO[SbVOa]\S OZ]\S

µ 7\ ORRWbW]\ g]c QO\ ^`SaQ`WPS @3H=<71 eWbV []`S Q]\¿RS\QS W\ ^ObWS\ba bOYW\U eO`TO`W\ 1ZW\WQOZ ^VO`[OQ]Z]Ug abcRWSa VOdS RS[]\ab`ObSR bVOb @3H=<71 R]Sa \]b VOdS O QZW\WQOZZg `SZSdO\b W[^OQb ]\ bVS ^VO`[OQ]YW\SbWQa ]` ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\ ¶

/A >/@B =4 /< /<B73;3B71 @357;3<

AO[^ZS aOZSa [SaaOUS

AW\UZS =`OZ 2]aS( / aW\UZS ]`OZ R]aS ]T # [U @3H=<71 OR[W\WabS`SR ! b] $ [W\cbSa ^`W]` b] QVS[]bVS`O^g ]\ ROg ]\Zg ! 2Og 7D =`OZ( / ! [W\cbS 7D W\TcaW]\ ]T ' [U @3H=<71 OR[W\WabS`SR ! b] $ [W\cbSa ^`W]` b] QVS[]bVS`O^g ]\ ROg T]ZZ]eSR Pg # [U @3H=<71 ]`OZ R]aSa ]\ ROga O\R ! 1]\b`]Z( H=4@/< ! [U 7D O\R RSfO[SbVOa]\S [U ]`OZ ]\QS ROWZg ]\ ROg O\R RSfO[SbVOa]\S & [U ]`OZ beWQS ROWZg ]\ ROga b] " BVS R]aSa ]\ ROg O\R ROg ! aV]cZR PS bOYS\ O^^`]fW[ObSZg " O\R "& V]c`a `Sa^SQbWdSZg T]ZZ]eW\U bVS ¿`ab R]aS ]T @3H=<71 Á 1]\b`]Z( H=4@/< & [U ]`OZ beWQS ROWZg O\R RSfO[SbVOa]\S & [U 7D ]\ ROg O\R H=4@/< & [U ]`OZ beWQS ROWZg ]\ ROga O\R ! 6g^]bVSbWQOZ ^ObWS\b ^`]¿ZS <]b OQbcOZ ^ObWS\b ]` ^VgaWQWO\

@3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba 1]OR[W\Wab`ObW]\ ]T @3H=<71 [Og `SRcQS bVS ST¿QOQg ]T V]`[]\OZ Q]\b`OQS^bWdSa ASS ^OUS $ T]` []`S W\T]`[ObW]\ ]\ ^`SQOcbW]\O`g [SOac`Sa 7 \Q`SOaSa W\ ]`OZ RSfO[SbVOa]\S Sf^]ac`S VOdS PSS\ ]PaS`dSR eVS\ Q]OR[W\WabS`SR eWbV ]`OZ @3H=<71 ASS ^OUS ' T]` []`S W\T]`[ObW]\ ]\ R]aS ORXcab[S\ba

>ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

NEW

"

#

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

µ @3H=<71 Wa O VWUVZg STTSQbWdS O\bWS[SbWQ eVS\ caSR W\ Q][PW\ObW]\ eWbV O # 6B! O\R O Q]`bWQ]abS`]WR Tc`bVS` ^`SdS\bW\U 17<D W\ ^ObWS\ba `SQSWdW\U SWbVS` VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g 7 e]cZR ZWYS b] \]e aVO`S eWbV g]c bVS


>/53 $

>/53 %

/2D3@A3 @3/1B7=<A

/2D3@A3 @3/1B7=<A

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] QZSO`Zg Q][[c\WQObS bVS ORdS`aS `SOQbW]\a bVOb ]QQc``SR Rc`W\U bVS QZW\WQOZ b`WOZa ]T @3H=<71

AO[^ZS aOZSa [SaaOUS

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

µ 7\ `SUO`R b] bVS aOTSbg ^`]¿ZS ]T @3H=<71 bVS ORdS`aS SdS\ba O^^SO`W\U W\ U`SObS` bVO\ ]T ^ObWS\ba `SQSWdW\U VWUVZg S[Sb]US\WQ QVS[]bVS`O^g eS`S \Scb`]^S\WO ZScY]^S\WO bV`][P]Qgb]^S\WO O\R O\S[WO ¶

µ BVS ORdS`aS SdS\ba ]QQc``W\U W\ U`SObS` bVO\ ]T ^ObWS\ba W\ bVS []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g b`WOZ eS`S \Scb`]^S\WO OZ]^SQWO O\R TObWUcS ¶

A/43BG >@=47:3 7< BE= >6/A3 ! 1:7<71/: B@7/:A <+ &'#

;]RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

6WUVZg S[Sb]US\WQ QVS[]bVS`O^g

/2D3@A3 @3/1B7=<A =11C@@7<5 7< t# =4 >/B73<BA @3137D7<5 ;=23@/B3:G 3;3B=53<71 163;=B63@/>G @3H=<71 =<2/<A3B@=< /<2 23F/;3B6/A=<3´1G1:3

/2D3@A3 @3/1B7=<A =11C@@7<5 7< t# =4 >/B73<BA @3137D7<5 6756:G 3;3B=53<71 163;=B63@/>G @3H=<71 =<2/<A3B@=< /<2 23F/;3B6/A=<3´1G1:3 AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ \+ $%

7[^]`bO\b TOQb Â’ 7b Wa Q`WbWQOZ bVOb ]c` Qcab][S`a c\RS`abO\R bVOb bVSaS ORdS`aS `SOQbW]\a Q]cZR PS Obb`WPcbOPZS b] bVS QVS[]bVS`O^g WbaSZT ]` b] bVS Q]\Q][WbO\b [SRWQObW]\a ^ObWS\ba eS`S `SQSWdW\U Rc`W\U bVS b`WOZa

]\RO\aSb`]\S RSfO[SbVOa]\S \+ $#

<Scb`]^S\WO

!

!#

%

:ScY]^S\WO

&

"

!

'

/\S[WO

&

$

1]\abW^ObW]\

$

&

4ObWUcS

%

$

/\]`SfWO

&

'

#

6WQQc^a

$

%

BV`][P]Qgb]^S\WO

Â’ BVS b`WOZ RSaWU\a T]` @3H=<71 eS`S dS`g ab`W\US\b OP]cb V]e bVSg SdOZcObSR ORdS`aS SdS\ba 1ZW\WQOZ ZOP]`Ob]`g O\R VS[Ob]Z]UWQ aQ`SS\W\Ua eS`S ^S`T]`[SR ]\ ROg Ob bVS Q][^ZSbW]\ ]T bVS ¿`ab QgQZS O\R Ob bVS S\R ]T OZZ acPaS_cS\b QgQZSa /\ ORRWbW]\OZ VS[Ob]Z]Ug aQ`SS\W\U eOa R]\S ]\ ROga b] %

! 2Og 7D =`OZ @3H=<71 @SUW[S\ \+ %

AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ \+"&

! 2Og 7D =`OZ @3H=<71 @SUW[S\ \+"%'

]\RO\aSb`]\S RSfO[SbVOa]\S \+"%'

"

!&

!%

%

#

#

4ObWUcS

'

$

#

2ga^S^aWO

%

%

#

2WO``VSO

%

$

!

<Scb`]^S\WO /Z]^SQWO

/\]`SfWO

%

$

$

/\S[WO

#

#

"

2WhhW\Saa

"

/:B W\Q`SOaSR

$

!

"

"

AO[^ZS aOZSa [SaaOUS µ :]]YW\U Ob VS[Ob]Z]UWQ OP\]`[OZWbWSa W\ U`ORSa ! O\R " bVS`S eOa O RWTTS`S\QS W\ \Scb`]^VWZa da Q]\b`]Z 7\ ORRWbW]\ @3H=< 71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV R`cUa bVOb O`S VWUVZg RS^S\RS\b ]\ 1G>!/ T]` QZSO`O\QS ¶

0Z]]R Q`SObW\W\S W\Q`SOaSR 2WhhW\Saa

BVS P`WRUS

>3@13<B =4 >/B73<BA @3137D7<5 6756:G 3;3B=53<71 163;=B63@/>G @3H=<71 =<2/<A3B@=< /<2 23F/;3B6/A=<3 E7B6 5@/23 ! /<2 5@/23 " 63;/B=:=571 /0<=@;/:7B73A´1G1:3 AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ \+ $% 6S[Ob]Z]UWQ ^O`O[SbS`a

! 2Og 7D =`OZ @3H=<71 @SUW[S\ \+ %

5`ORS !

5`ORS "

5`ORS !

5`ORS "

2SQ`SOaSR VS[]UZ]PW\

*

2SQ`SOaSR ^ZObSZSba

#

2SQ`SOaSR \Scb`]^VWZa

"

! $

!

%

AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ \+"&

]\RO\aSb`]\S RSfO[SbVOa]\S \+ $#

! 2Og 7D =`OZ @3H=<71 @SUW[S\ \+"%'

]\RO\aSb`]\S RSfO[SbVOa]\S \+"%'

5`ORS !

5`ORS "

5`ORS !

5`ORS "

5`ORS !

5`ORS "

2SQ`SOaSR VS[]UZ]PW\

*

*

*

!

2SQ`SOaSR ^ZObSZSba

*

*

*

*

#

!

!

%

&

%

5`ORS !

5`ORS "

µ 7\ ORRWbW]\ b] ORdS`aS `SOQbW]\a bVS`S Wa a][S W[^]`bO\b W\T]`[ObW]\ 7 e]cZR ZWYS b] aVO`S eWbV g]c `SUO`RW\U OQQSaa O\R @3H=<71 aOTSbg ¶

>3@13<B =4 >/B73<BA @3137D7<5 ;=23@/B3:G 3;3B=53<71 163;=B63@/>G @3H=<71 =<2/<A3B@=< /<2 23F/;3B6/A=<3 E7B6 5@/23 ! /<2 5@/23 " 63;/B=:=571 /0<=@;/:7B73A´1G1:3

6S[Ob]Z]UWQ ^O`O[SbS`a

2SQ`SOaSR \Scb`]^VWZa

@3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa O\R \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^WSa

ASS ^OUS " T]` Tc`bVS` W\T]`[ObW]\ OP]cb R]aW\U ]T bVS @3H=<71 @SUW[S\

>ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba

ONE NK-1 DOSE. 5-DAY PREVENTION.

/2D3@A3 @3/1B7=<A

@3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba

NEW

$

%

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


>/53 &

>/53 '

/113AA 7;>=@B/<B A/43BG 7<4=@;/B7=<

/113AA 7;>=@B/<B A/43BG 7<4=@;/B7=<

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa a^`SOR Wa b] OZZSdWObS Q]\QS`\a `SUO`RW\U OQQSaa O\R `SW[Pc`aS[S\b OaaWabO\QS O\R b] aVO`S bVS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ eWbV Qcab][S`a

AO[^ZS aOZSa [SaaOUS

AO[^ZS aOZSa [SaaOUS

ONE REZONIC DOSE. 5-DAY PREVENTION.

µ 5ZOf]A[WbV9ZW\S PSZWSdSa OZZ ^ObWS\ba aV]cZR VOdS OQQSaa b] bVS b`SOb[S\ba bVSg \SSR O\R bVOb bVS ^`]QSaa ]T `SW[Pc`aS[S\b aV]cZR PS Oa aW[^ZS Oa ^]aaWPZS 4]` @3H=<71 bVS`S Wa O Q][^`SVS\aWdS `SW[Pc`aS[S\b OaaWabO\QS ^`]U`O[ eWbV RSRWQObSR ^S`a]\\SZ O\R O @3H=<71 1O`Sa ^`]U`O[ T]` ^ObWS\ba W\ \SSR ¶

µ <]e ZSb¸a RWaQcaa bVS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` bVS ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg O\R []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g @3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV R`cUa bVOb O`S VWUVZg RS^S\RS\b ]\ 1G>!/ T]` QZSO`O\QS) T]` SfO[^ZS RSfO[SbVOa]\S 7\ ^VOaS ! b`WOZa eWbV @3H=<71 O R]aS `SRcQbW]\ ]T ]`OZ RSfO[SbVOa]\S eOa caSR /Za] Q]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV ]bVS` QVS[]bVS`O^g OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba 4W\OZZg QV`]\WQ ROWZg caS ]T @3H=<71 T]` bVS ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U VOa \]b PSS\ abcRWSR ¶

1=;>@363<A7D3 @37;0C@A3;3<B /AA7AB/<13 E7B6 / A7<5:3 >6=<3 1/:: 7[^]`bO\b AOTSbg 7\T]`[ObW]\

2SRWQObSR >S`a]\\SZ 1]dS`OUS WRS\bW¿QObW]\ O\R QZOW[a ^`]QSaaW\U ´ /ZbS`\ObWdS `SQ][[S\RObW]\a T]` ^ObWS\ba eWbV ZW[WbSR ]` \] Q]dS`OUS 3fbS\RSR RObW\U Wa OdOWZOPZS b] TOQWZWbObS [O\cOZ ^`]QSaaW\U ]T [WaQSZZO\S]ca 8 Q]RSa

1][^`SVS\aWdS ^`W]` OcbV]`WhObW]\ ac^^]`b 1ZOW[a b`OQYW\U 1ZOW[a RS\WOZ O^^SOZ OaaWabO\QS

EO`\W\Ua O\R >`SQOcbW]\a @3H=<71 Wa O R]aS RS^S\RS\b W\VWPWb]` ]T 1G>!/ ESOY b] []RS`ObS W\VWPWbW]\ ]T 1G>!/ T]ZZ]eW\U OR[W\Wab`ObW]\ ]T @3H=<71 R]aS `SUW[S\a W\RWQObSR T]` bVS ^`SdS\bW]\ ]T 17<D [Og `SacZb W\ SZSdObSR ^ZOa[O Q]\QS\b`ObW]\a ]T Q]OR[W\WabS`SR 1G>!/ acPab`ObSa 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba

5A9 Ac^^]`b 1S\bS` OaaWabO\QS

2`cU 7\bS`OQbW]\a 1G>!/ [SbOP]ZWhSR 1VS[]bVS`O^g /US\ba( 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QS`bOW\ QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ S U dW\]`SZPW\S Sb]^]aWRS [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba acQV Oa 5`ORS " \Scb`]^S\WO

3Oag /QQSaa @SW[Pc`aS[S\b T]`[a OdOWZOPZS Ob eee `Sh]\WQ Q][

@3H=<71 1O`Sa Ac^^]`b ^`]U`O[ T]` SZWUWPZS ^ObWS\ba eV] ZOQY acT¿QWS\b Q]dS`OUS

5A9 Ac^^]`b 1S\bS`

1]\b`OW\RWQObW]\a @3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV R`cUa bVOb O`S VWUVZg RS^S\RS\b ]\ 1G>!/ T]` QZSO`O\QS O\R T]` eVWQV SZSdObSR ^ZOa[O Q]\QS\b`ObW]\a O`S Oaa]QWObSR eWbV ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS

Ob eee `Sh]\WQ Q][

& ### !" ;]\ROg³4`WROg & /;³& >; 3OabS`\ BW[S

2SfO[SbVOa]\S( 7\Q`SOaSa W\ ]`OZ RSfO[SbVOa]\S Sf^]ac`S VOdS PSS\ ]PaS`dSR eVS\ Q]OR[W\WabS`SR eWbV ]`OZ @3H=<71 / `SRcQbW]\ W\ ]`OZ RSfO[SbVOa]\S R]aS [Og PS Q]\aWRS`SR eVS\ OR[W\WabS`SR eWbV @3H=<71 @3H=<71 R]Sa \]b VOdS O QZW\WQOZZg `SZSdO\b W[^OQb ]\ bVS ^VO`[OQ]YW\SbWQa ]T aW\UZS R]aSa ]T 7D =`OZ 1]\b`OQS^bWdSa( 1]OR[W\Wab`ObW]\ ]T @3H=<71 [Og `SRcQS bVS ST¿QOQg ]T V]`[]\OZ Q]\b`OQS^bWdSa >ObWS\ba aV]cZR PS W\ab`cQbSR b] caS OZbS`\ObWdS [SbV]Ra ]T Q]\b`OQS^bW]\ acQV Oa R]cPZS PO``WS` Rc`W\U b`SOb[S\b eWbV @3H=<71 O\R T]` $ eSSYa T]ZZ]eW\U bVS ZOab R]aS ]T @3H=<71 2c`ObW]\ ]T CaS 1V`]\WQ ROWZg caS ]T @3H=<71 Wa \]b `SQ][[S\RSR BVS QV`]\WQ ROWZg caS ]T @3H=<71 T]` ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U VOa \]b PSS\ abcRWSR O\R Wb [Og OZbS` bVS R`cU W\bS`OQbW]\ ^`]¿ZS

7[^]`bO\b TOQb

/RdS`aS @SOQbW]\a W\ 1ZW\WQOZ B`WOZa EWbV VWUVZg S[Sb]US\WQ QVS[]bVS`O^g bVS T]ZZ]eW\U ORdS`aS `SOQbW]\a ]QQc``SR W\ ≥ ]T ^ObWS\ba bOYW\U @3H=<71 ^Zca O abO\RO`R O\bW S[SbWQ `SUW[S\ ]T ]\RO\aSb`]\ O\R RSfO[SbVOa]\S dS`aca bVS abO\RO`R O\bW S[SbWQ `SUW[S\ OZ]\S( \Scb`]^S\WO !# da % ZScY]^S\WO da " bV`][P]Qgb]^S\WO ! da O\S[WO da $ Q]\abW^ObW]\ da & O\R 4ObWUcS da $ @37;0C@A3;3<B A/43BG

EWbV []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g bVS T]ZZ]eW\U /RdS`aS @SOQbW]\a ]QQc``SR W\ ≥ ]T ^ObWS\ba bOYW\U @3H=<71 ^Zca O abO\RO`R O\bW S[SbWQ `SUW[S\ ]T ]\RO\aSb`]\ O\R RSfO[SbVOa]\S dS`aca bVS abO\RO`R O\bW S[SbWQ `SUW[S\ OZ]\S( \Scb`]^S\WO " da !% OZ]^SQWO % da # TObWUcS ' da # 0ST]`S ^`SaQ`WPW\U @3H=<71 ^ZSOaS `SOR OQQ][^O\gW\U >`SaQ`WPW\U 7\T]`[ObW]\ 7\RWQObW]\ @3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa) O\R T]` bVS ^`SdS\bW]\ ]T \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^WSa @STS`S\QSa( @Sh]\WQ >`SaQ`WPW\U 7\T]`[ObW]\ @SaSO`QV B`WO\UZS >O`Y <1( 5ZOf]A[WbV9ZW\S) & H]T`O\ >`SaQ`WPW\U 7\T]`[ObW]\ @SaSO`QV B`WO\UZS >O`Y <1( 5ZOf]A[WbV9ZW\S) $ ! 3[S\R >`SaQ`WPW\U 7\T]`[ObW]\ EVWbSV]caS AbObW]\ <8( ;S`QY 1] 7\Q) $ " 2ObO ]\ ¿ZS 5ZOf]A[WbV9ZW\S >VWZORSZ^VWO >/

ONE NK-1 DOSE. 5-DAY PREVENTION.

NEW

&

'

7\ [O`YSb `SaSO`QV Qcab][S`a eS`S _cWbS Q]\QS`\SR OP]cb bVS 1G>!/ W\bS`OQbW]\a Oa aSdS`OZ QVS[]bVS`O^g OUS\ba O`S [SbOP]ZWhSR dWO bVWa ^ObVeOg BVS`S eOa \]b QZSO` c\RS`abO\RW\U bVOb 3[S\R OZa] QO``WSa bVWa eO`\W\U O\R bVOb Wb Wa ZWYSZg O QZOaa STTSQb 1ZSO`Zg Q][[c\WQObW\U bVWa b] Qcab][S`a Wa ]T bVS cb[]ab W[^]`bO\QS b] Od]WR ^]bS\bWOZZg aS`W]ca R`cU W\bS`OQbW]\a

BVS P`WRUS µ BVO\Y g]c T]` g]c` bW[S b]ROg b] VSO` OP]cb bVS aWU\W¿QO\b PS\S¿ba O\R aOTSbg W\T]`[ObW]\ ]T \Se @3H=<71 7\ QZ]aW\U 7¸R ZWYS b] `SQO^ bVS YSg ^]W\ba b] `S[S[PS` bVS \Sfb bW[S g]c O`S ^`SaQ`WPW\U O\ O\bWS[SbWQ `SUW[S\ ¶

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


>/53

0/19 1=D3@

<=B3A

1]`S ]PXSQbWdS BVS ]PXSQbWdS ]T bVWa ^OUS Wa b] S\ac`S bVOb Qcab][S`a VOdS O QZSO` c\RS`abO\RW\U ]T @3H=<71 O\R Wba YSg PS\S¿ba Oa eSZZ Oa b] QZ]aS bVS QOZZ Pg OaYW\U T]` bVS PcaW\Saa

AO[^ZS aOZSa [SaaOUS µ /a ^O`b ]T O\ O\bWS[SbWQ `SUW[S\ AW\UZS =`OZ 2]aS @3H=<71 Wa O \Se T]`QS T]` # ROg 17<D ^`SdS\bW]\ @3H=<71 RS[]\ ab`ObSR VWUV ST¿QOQg `ObSa T]` # TcZZ ROga W\ P]bV VWUVZg O\R []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g bVOb eS`S acabOW\SR ]dS` acPaS_cS\b QgQZSa ¶

ONE REZONIC DOSE. 5-DAY PREVENTION

7<B@=2C17<5 / <3E <9 @313>B=@ /<B/5=<7AB /A >/@B =4 /< /<B73;3B71 @357;3<

A7<5:3 =@/: 2=A3 @3H=<71 / <3E 4=@13 4=@ # 2/G 17<D >@3D3<B7=< 6WUV ST¿QOQg `ObSa T]` # TcZZ ROga \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS bVS`O^g &$ W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

7[^]`bO\b TOQb

%! W\ []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g

0S ac`S b] S[^VOaWhS eWbV Qcab][S`a bVOb @3H=<71 Wa OZeOga caSR W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQa # 6B! O\R O Q]`bWQ]abS`]WR

>ObWS\b ROWZg Tc\QbW]\OZ ZWdW\U [OW\bOW\SR W\ VWUVZg S[Sb]US\WQ QVS[]bVS`O^g

AO[^ZS aOZSa [SaaOUS µ %% ]T ^ObWS\ba `SQSWdW\U @3H=<71 `S^]`bSR VOdW\U \] W[^OQb ]T 17<D ]\ bVSW` ROWZg ZWdSa ¶

3T¿QOQg [OW\bOW\SR bV`]cUV " VWUVZg ]` []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g QgQZSa %% ]T ^ObWS\ba `S^]`bSR \] W[^OQb ]T 17<D ]\ bVSW` ROWZg ZWdSa BVS =\Zg 2Og AW\UZS =`OZ 2]aS <9 /Za] OdOWZOPZS W\ O ! 2Og 7D =`OZ `SUW[S\ CaSR W\ Q][PW\ObW]\ eWbV [cZbWROg # 6B O\R RSfO[SbVOa]\S >ZSOaS aSS ^OUS " T]` []`S W\T]`[ObW]\ AOTSbg ^`]¿ZS W\ P]bV ]`OZ O\R 7D 1Oa]^WbO\b R]Sa \]b W[^OQb bVS ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\ Rc`W\U Q]OR[W\Wab`ObW]\ @3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>! R`cUa acQV Oa OabS[Wh]ZS QWaO^`WRS ]` ^W[]hWRS RcS b] ^]bS\bWOZZg aS`W]ca O\R ]` ZWTS bV`SObS\W\U `SOQbW]\a @3H=<71 Wa O R]aS RS^S\RS\b 1G>!/ W\VWPWb]` 1]OR[W\Wab`ObW]\ ]T @3H=<71 eWbV QVS[]bVS`O^ScbWQ OUS\ba ^`W[O`WZg [SbOP]ZWhSR Pg 1G>!/ [Og `SacZb W\ W\Q`SOaSR b]fWQWbWSa ]T bVSaS OUS\ba BVS []ab Q][[]\ t ORdS`aS `SOQbW]\a W\ ^ObWS\ba eWbV @3H=<71 T]` bVS ^`SdS\bW]\ ]T 17<D( \Scb`]^S\WO OZ]^SQWO TObWUcS ZScY]^S\WO bV`][P]Qgb]^S\WO Q]\abW^ObW]\ O\R O\S[WO 5A9 Ac^^]`b 1S\bS`´ & ### !"´Q][^`SVS\aWdS `SW[Pc`aS[S\b OaaWabO\QS eWbV O aW\UZS ^V]\S QOZZ

AO[^ZS aOZSa [SaaOUS µ @3H=<71 Wa OZa] STTSQbWdS eVS\ R]aSR 7D ]\ ROg T]ZZ]eSR Pg ]`OZ ]\ ROga O\R ! ¶

AO[^ZS aOZSa [SaaOUS µ BVS aOTSbg ]T @3H=<71 VOa PSS\ SdOZcObSR W\ \SO`Zg ! ^ObWS\ba @3H=<71 R]Sa \]b W[^OQb bVS ^VO`[OQ]Rg\O[WQa ]T eO`TO`W\ O\R bVS []ab T`S_cS\bZg ]QQc``W\U ORdS`aS `SOQbW]\a ]dS` OZZ QgQZSa eS`S \Scb`]^S\WO OZ]^SQWO TObWUcS ZScY]^S\WO bV`][P]Qgb]^S\WO Q]\abW^ObW]\ O\R O\S[WO EWZZ g]c ^`SaQ`WPS @3H=<71 R]aS T]` # ROg ^`SdS\bW]\ T]` g]c` P]bV g]c` VWUVZg /<2 []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^g ^ObWS\ba-¶

>`SaQ`WPS bVS \Se AW\UZS =`OZ 2]aS @3H=<71 @SUW[S\ > b] VSZ^ ^`SdS\b 17<D T]` # TcZZ ROga

@3H=<71 W\ Q][PW\ObW]\ eWbV ]bVS` O\bWS[SbWQ OUS\ba Wa W\RWQObSR T]` ^`SdS\bW]\ ]T OQcbS O\R RSZOgSR \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T VWUVZg S[Sb]US\WQ QVS[]bVS`O^WSa O\R \OcaSO O\R d][WbW\U Oaa]QWObSR eWbV W\WbWOZ O\R `S^SOb Q]c`aSa ]T []RS`ObSZg S[Sb]US\WQ QVS[]bVS`O^WSa >ZSOaS aSS 7[^]`bO\b AOTSbg 7\T]`[ObW]\ ]\ ^OUS ' O\R OQQ][^O\gW\U Q][^ZSbS >`SaQ`WPW\U 7\T]`[ObW]\ W\QZcRW\U eO`\W\Ua ^`SQOcbW]\a O\R ORdS`aS SdS\ba 1][^ZSbS `Sa^]\aS eOa RS¿\SR Oa \] d][WbW\U `SbQVW\U O\R \] caS ]T `SaQcS [SRWQObW]\ T`][ ROga bV`]cUV # b] V]c`a @O\R][WhSR R]cPZS PZW\R Q]\b`]ZZSR ^O`OZZSZ U`]c^ abcRWSa W\ ^ObWS\ba `SQSWdW\U VWUVZg <+& ]` []RS`ObSZg <+ '!! S[Sb]US\WQ QVS[]bVS`O^g

& BVS 5ZOf]A[WbV9ZW\S 5`]c^ ]T 1][^O\WSa /ZZ `WUVba `SaS`dSR >`W\bSR W\ CA/ I1]RSK I2ObSK

ONE NK-1 DOSE. 5-DAY PREVENTION.

NEW

7[^]`bO\b TOQb @S[S[PS` @3H=<71 Wa Q]\b`OW\RWQObSR W\ Q][PW\ObW]\ eWbV VWUVZg RS^S\RS\b 1G>!/ R`cUa

@STS`S\QSa( 2ObO ]\ ¿ZS 5ZOf]A[WbV9ZW\S >VWZORSZ^VWO >/ @3H=<71 >`SaQ`WPW\U 7\T]`[ObW]\ @SaSO`QV B`WO\UZS >O`Y <1( 5ZOf]A[WbV9ZW\S) & ! 3[S\R >`SaQ`WPW\U 7\T]`[ObW]\ EVWbSV]caS AbObW]\ <8( ;S`QY 1] 7\Q) & " 5`c\PS`U ; 2Sca]\ @ ;Od`]a > 5SZW\U = Sb OZ 7\QWRS\QS ]T QVS[]bVS`O^g W\RcQSR \OcaSO O\R S[SaWa OTbS` []RS`\ O\bWS[SbWQa 1O\QS` ") ( $ $& # 7\b`W\aW? []\bVa S\RW\U /^`WZ & $ 6SaYSbV > 2S¿\W\U bVS S[Sb]US\WQWbg ]T QO\QS` QVS[]bVS`O^g `SUW[S\a( `SZSdO\QS b] QZW\WQOZ ^`OQbWQS =\Q]Z]UWab ''')"( ' '$

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A

4=@ 7<B3@</: B@/7<7<5 >C@>=A3A =<:G <=B B= 03 CA32 E7B6 63/:B6 1/@3 >@=43AA7=</:A


Issuu converts static files into: digital portfolios, online yearbooks, online catalogs, digital photo albums and more. Sign up and create your flipbook.