Cosmetiscope Apr 2018

APRIL 2018 • Vol. 24 No. 4

New York Society of Cosmetic Chemists

www.nyscc.org

Multi-targeted Delivery Strategy to Eliminate Dark Spots …by Martha L. Vázquez-González, Lucyanna Barbosa-Barros, and Olga López

INTRODUCTION

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kin pigmentation results from the synthesis and distribution of melanin in the skin. Increased melanin production is a result of either UV exposure or various disorders. The resulting dark spots, also called age spots, are permanent and increase over time with aging, being one of the main concerns of middle-aged women all over the world.1 There are several active ingredients that minimize these processes; however, most of them present serious limitations of use often related to their efficacy and safety. Some active ingredients are very aggressive and cause irritation. Some skin lightening agents can also be unspecific, causing depigmentation in areas that are not hyperpigmented, whereas others do not reach the desired site of action and lack efficacy.2 An efficient treatment to eliminate dark spots should promote penetration of the active ingredients to the site of action to prevent and block the principal processes involved in the formation, transport, and elimination of melanin.

It is also very important that the treatment be specific to the hyperpigmented areas in order to unify skin tone. Finally, the treatment should be respectful to the skin’s microstructure and maintain tissue health.

MULTI-TARGETED DELIVERY STRATEGY Bicosome is a skin delivery technology formed by two structures: internal smart disks that can incorporate different active ingredients, plus an external vesicle that encloses the disk structures as shown in Figure 1A. Bicosome structures are able to penetrate the skin, target

Figure 1: (A) Cryo-TEM (transmission electron microscopy) image of a bicosome (bar = 200 nm), (B) mechanism of bicosome penetration and delivery of actives into the skin, and (C) multi-target action of Bicowhite designed to block five main processes involved in the formation of dark spots.

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C O S M E T I C S I N T H E M I D D L E E A S T: A R E G U L AT O R Y P E R S P E C T I V E A p r i l 2 5 • L i b e r t y S c i e n c e C e n t e r, J e r s e y C i t y, N J

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2018 NYSCC BOARD OF DIRECTORS & PROGRAM CHAIRS CHAIR Cathy Piterski chair@nyscc.org

CHAIR-ELECT Sonia Dawson chair-elect@nyscc.org

TREASURER Michael Smith Treasurer@nyscc.org

TREASURER-ELECT Stephen Carter treasurer-elect@nyscc.org

SECRETARY Roumelia Alina secretary@nyscc.org

ADVISOR Marie Thadal advisor@nyscc.org

HOUSE Suzanne Dawis house@nyscc.org

MEMBERSHIP Mohamed Abdulla mohamed.abdulla@airliquide.com

PROGRAM Steve Herman steveh50@optonline.net

COMMUNICATIONS Theresa Phamduy webmaster@nyscc.org

SPECIAL EVENTS Amy Marshall amy.marshall@altana.com

COSMETISCOPE EDITOR Roger McMullen roger_mcmullen@fdu.edu

COSMETISCOPE ADVERTISING Bret Clark rbclark@ashland.com 2

Monthly Meeting Group Discount The NYSCC is offering a group discount of 15% to companies who send 5 or more employees to a monthly meeting. All five employees would need to be registered at the same time to receive the discount. Once purchased, registrations are non-refundable.

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Letter from the Chair

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…Cathy Piterski

he nor’easters have not stopped and neither have we! The day after one of these recurring storms, the NYSCC and American Society of Perfumers held a symposium themed Fragrance Today: Science – Regulation – Creation.

There was record registration for the event, which took place on March 22nd at the Legacy Castle in Pompton Plains, NJ. Once again, we had to deal with snow and hazardous road conditions. While many attendees did not make the first bell, by 10:00 a.m. the room was full, the engagement was real, and the conference retained its “record-breaking attendance” title! Many thanks to Steve Herman for pulling together the extraordinary program in such a remarkable venue. The theme of “Art and Science” resonated and was a great “preview” for this year’s Suppliers’ Day themed “The Art and Science of Formulation!”

Our next symposium is on April 25th at the Liberty Science Center entitled Cosmetics in the Middle East: A Regulatory Perspective. Trends will be a focal point and the halal designation will be one of the key takeaways from the day’s content and information exchange.

It is shocking to think that we are almost at the mid-point of the year and that our next Cosmetiscope issue will focus on NYSCC Suppliers’ Day, taking place May 15-16, 2018 at the Jacob K. Javits Center in New York City. The show is the anchor of what has become known as “Beauty Week NYC.” Suppliers’ Day is poised to offer the most innovative solutions currently available across the globe and will feature more than 50 individual conference sessions and curated educational programs, and 450+ exhibitors with attendees representing 60+ countries. Specialty areas on the show floor include the Future Chemists Workshop, Presentation Theater, and French Pavillion. If you have not registered to attend, do so today. Review all the latest updates on the Suppliers’ Day website and know, without a doubt, that this is the must-attend North American exposition!

Hopefully, when we meet at the April symposium, we will have ditched our snow boots and are sporting some sunglasses! Until then, ensure that you register for upcoming programs including Suppliers’ Day, and also encourage your colleagues to join the SCC, if they are not already members. Our offerings have expanded, the networking is unmatched, and the ability to become involved and influence the trajectory of your career is real!

Upcoming 2018 NYSCC Events Calendar • For updated NYSCC information, visit us on the web at: www.nyscc.org • For National SCC information: www.scconline.org April 25 Cosmetics in the Middle East: A Regulatory Perspective – Liberty Science Center, Jersey City, NJ May 15-16 NYSCC Suppliers’ Day – Jacob K. Javits Convention Center, New York, NY June 5 Microbiome Symposium – L’Oréal USA, Clark, NJ July 23 NYSCC Golf Outing – Crystal Springs Golf Course, Hamburg, NJ September 12 Sunscreen Symposium: Extending Your Invisible Umbrella – Renaissance Woodbridge Hotel, Iselin, NJ September 20 Culinary Event – Midtown Loft & Terrace, New York, NY October 17 Sustainable Cosmetic Science Seminar – Chart House, Weehawken, NJ November 7 Inflammatory Skin Diseases and Barrier Function Seminar – Valley Regency, Clifton, NJ

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Multi-targeted Delivery Strategy to Eliminate Dark Spots

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specific skin layers, and deliver the active ingredients where they are needed. The biomimetic mechanism of interaction of bicosomes with the skin allows for the active ingredients to be released slowly over time while bicosome’s own lipid structures reinforce the skin. Bicosomes remain in the skin until they are freed through the skin’s renewal process (Figure 1B).

In this study, we evaluated the in vitro and in vivo efficacy of a sophisticated bicosome complex containing five active ingredients, which is referred to hereinafter as Bicowhite. Bicowhite aims to act simultaneously on five processes that lead to the formation of dark spots by (1) inhibiting melanin formation and (2) transfer, (3) blocking inflammatory processes and (4) oxidative stress, and (5) accelerating cell renewal. The bicosomes boost the efficacy of each active ingredient by transporting them to the target levels of the skin where they should work, as indicated in Figure 1C.

IN VITRO EFFICACY STUDIES Assessment of Whitening Activity In this experiment, 1% and 3% Bicowhite solutions were applied to reconstructed human epidermis tissues and compared with 0.1% kojic acid. After treatment, the amount of melanin per mg of epithelium was measured and compared with the control. In four days of treatment, 1% and 3% Bicowhite demonstrated a higher capacity to decrease melanin content than kojic acid (see Figure 2A).

Figure 2: (A) Melanin reduction after four applications in reconstructed human epidermis tissues, and (B) histological analysis of reconstructed human epidermis control tissue and tissues treated with 1% and 3% Bicowhite and 0.1% kojic acid.

Protective Effect on the Skin Structure As demonstrated in Figure 2B, histological analysis shows that tissues treated with Bicowhite at 1% and 3% were unaffected by the treatment. However, the tissue treated with kojic acid showed partial loss of stratum corneum and vacuolization in the granular layer, which indicates that this active ingredient promotes disruption of the skin structures. This assay demonstrates that the Bicowhite system exerts whitening activity without disrupting skin structures, which is explained by the mechanism of interaction of bicosome with the skin.

Whitening Activity in Skin Exposed to UV Radiation An adequate treatment to eliminate dark spots should be effective even when the skin is exposed to UV radiation, this way it is possible to have effective treatments yearround, even in summer. In order to assess the whitening activity of Bicowhite in skin exposed to UV radiation, a 10-day experiment was carried out using human skin explants. The irradiated explants received a 0.5-1 J/cm2 dose of UV light daily for nine days. Measurements were performed on day 0, 5, and 10. Figure 3 demonstrates that the use of 1% and 3% Bicowhite prevents an increase in 4

Figure 3: Melanin variation of skin explants not irradiated and not treated (light pink bar), irradiated and not treated (orange bar), irradiated and treated with 1% Biocowhite (light violet bar), and irradiated and treated with 3% Bicowhite.

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melanin content of skin explants exposed to UV radiation and even reduces the initial melanin values by 40-45% after 10 days.

IN VIVO EFFICACY STUDIES In order to evaluate the efficacy of the system, a clinical study was performed with 20 Caucasian females ranging from 35 to 65 years of age for 56 days. All volunteers used a gel formulation incorporating 3% Bicowhite, as the sole active ingredient, twice a day (morning and night).

Depigmenting Effect Figure 4A shows that the treatment with 3% Bicowhite gel reduced the melanin index (ΔM) by 26% after 56 days. In addition, as shown in Figure 4B, the non-hyperpigmented areas presented practically no variation of the melanin during the treatment, which indicates that the depigmenting effect is highly specific for the spot areas. This contributes not only to the depigmenting efficacy, but also helps even out skin tone.

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Figure 4: (A) Decrease of ΔM after 56 days of treatment with a 3% Bicowhite gel, and (B) melanin content in dark spots and non-hyperpigmented areas.

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The whitening and brightening effects of Bicowhite were seen in both spot and non-pigmented areas after 56 days of treatment with 3% Bicowhite gel; however, a much more pronounced effect is observed in the spot areas, indicating once again the high specificity of the treatment.

Figure 5: Whitening and luminosity effect assessed after 56 days of treatment with a 3% Bicowhite gel.

Colorimetric measurements were performed using a TM CM-700d Minolta spectrophotometer.

Clinical Evaluation Spot Color Intensity and Uniformity of the Skin The efficacy of Bicowhite was also assessed by clinical evaluation. Parameters related to spot color and uniformity of the skin were assessed on day 0, 28, and 56 of the study. Additionally, high resolution photographs of all volunteers were taken using a Fotofinder Medioscope system in reproducible lighting conditions.

After treatment with 3% Bicowhite gel, clinical evaluation indicates that the spot color intensity decreased by 34% and the uniformity of the skin improved by 35% after 56 days (Figure 6A).

The photographs of the volunteers clearly show the decrease of spot color and the unification of skin tone in relevant spots from day 0 to day 56 (Figure 6B, arrows).

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Multi-targeted Delivery Strategy to Eliminate Dark Spots

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Figure 6: (A) Clinical evaluation of spot color intensity and uniformity of the skin,

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and (B) high resolution photos of two volunteers before and after 56 days of treatment with 3% Bicowhite gel (arrows point to relevant spot areas).

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CONCLUSIONS The results of this study provide evidence that the proposed multi-target delivery strategy opens up new possibilities and may solve some of the most important limitations of whitening treatments, such as lack of penetration, disruption of skin structures, irritation, non-specificity, seasonality of treatments, and limited efficacy.

REFERENCES 1. G.E. Costin and V.J. Hearing, Human skin pigmentation: melanocytes modulate skin color in response to stress, FASEB J., 21, 976-994 (2007).

2. E.C. Davis and V.D. Callender, Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color, J. Clin. Aesthet. Dermatol., 3, 20-31 (2010).

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About the Authors n

Martha Vázquez González, Ph.D.

Martha Vázquez González graduated as a Chemical Engineer with a Master’s degree in Research, Development, and Control of Medicines. She completed her postgraduate work in Pharmaceutical Sciences with a Ph.D. specifically focused on transdermal drug delivery systems. Martha has nine years of experience in design, characterization, and evaluation of nanostructured systems, and is responsible for R&D project management and scientific publications at BICOSOME. n

Lucyanna Barbosa-Barros, Ph.D.

Lucyanna Barbosa-Barros completed a Doctor of Pharmacy and then went on to pursue postgraduate studies in Pharmaceutical Care and Management. Later, she pursued a Ph.D. in Pharmaceutical Technology, Master’s in Innovation, and Executive MBA. She is a businesswoman with experience in the management of multidisciplinary projects, basic and applied research, and design and development of skin care technologies.

She worked directly in the creation of Bicosome® technology and is co-founder and CEO of BICOSOME. 6

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Olga López, Ph.D.

Olga López holds a Ph.D. in Chemistry and has over 30 years of experience in lipid systems research and dermatological and cosmetic applications. She has a broad science curriculum at the Institute of Advanced Chemistry of the CSIC (IQAC-CSIC) and more than a hundred publications on lipid technologies to treat skin disorders. She is a pioneer in research with Bicosome® technology and is co-founder and Scientific Advisor of BICOSOME.

Call for Papers

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he Cosmetiscope editorial committee invites all interested parties to submit feature technical articles for publication in the NYSCC monthly newsletter. Authors of feature articles are eligible to win the prestigous NYSCC Literature Award ($1,000) for the best front-page article published during the calendar year. Also, authors receive $200 reimbursement to attend a theatrical performance of their choice.

Writing an article for your peers is a very rewarding experience, both personally and professionally, and would reserve your place in NYSCC history. You may choose whatever topic you feel would be interesting to fellow colleagues in our industry. We also welcome any other types of commentaries or articles that may be published in the Career Corner, Technical Tidbit section, or as a Letter to the Editor.

Please send correspondence to: roger_mcmullen@fdu.edu.

Microbiome Symposium June 5, 2018 L’Oréal USA, Clark, NJ

Join the Conversation Before SUPPLIERS’ DAY Doors Open!

• Follow the NYSCC and Suppliers’ Day on Twitter, Instagram, and Facebook.

• Send photos and press releases of things you wish to highlight and we will share it on our accounts.

• When talking about Suppliers’ Day on social media, use #SuppliersDayNY.

Like, Connect & Tweet About Us!

FACEBOOK: NEW YORK LINKED IN: NEW YORK SCC TWITTER: @NYSCC INSTAGRAM: NYSCCMAIN SOCIETY OF COSMETIC CHEMISTS These connections are possible by the NYSCC Social Media Committee

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Joint Symposium – March 22, 2018 ENJOY SUCCESSFUL PARTNERSHIPS Brenntag Specialties, Inc. 1 Cragwood Road, Suite 302 South Plainfield, NJ 07080 Phone: 800 732-0562 Fine Ingredients, Minerals, Colors, Surface Treatments, Proteins, Powders

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With strong roots, we’re green and growing.

Cosmetics in the Middle East: A Regulatory Perspective It’s only Bio.Logical. to contact us: (800) 223-7054 acme-hardesty.com

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April 25, 2018 • Liberty Science Center • Jersey City, NJ

any of us have heard of the term halal, or perhaps “The Halal Guys”, if you are from the tri-state area! Most of us associate the term with Islamic dietary laws. However, halal is not exclusive to the food industry anymore. Nor is halal solely connected to religion. Halal certification has become increasingly popular in the personal care industry and has signified a standard of quality. Clients are encouraging their manufacturers to become halal certified, and more and more raw material suppliers are becoming certified or proving compliance within halal guidelines. The NYSCC April 2018 event—Cosmetics in the Middle East: A Regulatory Perspective—will begin with a “Halal 101” lecture by Mohamed Omer of Revlon. This lecture will provide a comprehensive definition and overview of halal, its transition from the food to personal care industry, and why it is trending in cosmetics.

Afterwards, attendees will gain further insight on halal from three different perspectives within the personal care industry: raw materials, nail polish, and oral care manufacturers. John Gromley, the Director of Regulatory Affairs of Grant Industries, Inc. will share “The Essential Steps to Becoming a Global Halal Certified Ingredient Supplier”. Maya Cosmetics founders, Bilal Saeed and Javed Younis will discuss the making of Maya Cosmetics, manufacturer of luxurious, 100% halal, nail lacquers. And, Dr. Sayed Ibrahim, founder of Sprinjene, will share his story in developing an original, meticulously handcrafted, and halal certified toothpaste line.

Following these presentations, attendees can enjoy traditional Middle Eastern cuisine.

After lunch, we will take a look into the regulations of the Middle East. The Middle East is a leading market, and cosmetic companies are eager to sell their products in this region of the world. But, what does it take to have a finished product in the Middle East, from a legal stance? When it comes to regulatory affairs, most people agree that the European Union sets the most rigid framework with the EC 1223/2009, an outline that many other regions follow. The Middle East is, in fact, one of those regions.

However, it still has its own distinctions when it comes to processes, ingredients, labelling, and claims. George Bouboulis of the Personal Care Products Council (PCPC) will discuss the Middle East’s regulatory framework, known as GCC Regulation (GSO 1943/2016). This presentation will include an overview and a comparative look against the frameworks of the United States and European Union as well as a future look, as this regulatory outline is scheduled to be updated by 2020. In addition, attendees will learn about regulatory advocacy in the Middle East.

The event will close with a Halal Discussion Panel consisting of Gromley, Saeed, and Ibrahim, which will be moderated by Omer, to discuss the challenges and advantages regarding Halal Certification in the beauty industry.

To register for the event, please visit www.nyscc.org.

Event Chair

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– Leor Fay Tal

eor Fay Tal, who earned her B.A. in Biological Sciences from Rutgers University in 2010, took her first step into the personal care industry with MANA Products, a cosmetic manufacturing company, in June 2015. Leor began in Powder Lab R&D, with a focus on color. Leor’s great attention to detail allowed her to pick up shade matching quickly. Because her good eye allowed her to complete projects rapidly, she also took on the responsibly to reorganize the lab based on raw material and vendor, and establish an inventory system to replenish the lab. Her devotion to raw materials was quickly recognized. After a year in R&D, Leor was transferred to the Regulatory Department, where she is currently a Regulatory Affairs Specialist, with a focus on Raw

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Materials. There, she handles all matters regarding ingredients, including sourcing, vetting, document control, ensuring safety and compliance, coding, and much more. Leor Fay may be fairly new to personal care, but she is very happy to be working in such an exciting industry and always eager to learn and take on new projects and opportunities, including this NYSCC April 2018 event.

Agenda 9:00 – 9:30 a.m. Registration and Breakfast

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9:30 – 9:40 a.m. Introduction – Leor Fay Tal (MANA Products) 9:40 – 10:15 a.m. Halal 101 – Mohammed Omer (Revlon) 10:15 – 10:45 a.m. The Essential Steps to Becoming a Global Halal Certified Ingredient Supplier – John Gormley (Grant Industries Inc.)

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10:45 – 11:00 a.m. Break 11:00 – 11:30 a.m. Story of Maya Cosmetics – Javed Younis (Maya Cosmetics) and Bilal Saeed (Maya Cosmetics) 11:30 a.m. – 12:00 p.m. Story of Sprinjene – Sayed Ibrahim (Sprinjene) 12:00 – 1:00 p.m. Lunch 1:00 – 1:45 p.m. Overview of GCC Regulations (GSO 1943/2016) and Regulatory Advocacy – George Bouboulis (PCPC) 1:45 – 2:00 p.m. NYSCC Announcements – Cathy Piterski (Givaudan) and Mohamed Omer (Revlon) 2:00 – 3:00 p.m. Halal Discussion Panel – Sayed Ibrahim (Sprinjene), John Gormley (Grant Industries Inc.), Bilal Saeed (Maya Cosmetics), and Mohamed Omer (Moderator – Revlon)

--------------- Speakers and Abstracts ---------------

Halal 101

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– Mohamed Omer

e will start the event by providing a halal overview. Attendees will learn the definition of halal and its extension from the food industry to the personal care industry, develop an understanding of ingredients, become aware of its distinction from kosher, and gain insight on why it is trending with great demand in personal care. n Mohamed

Omer

Mohamed Omer is currently Hair Category Manager at Revlon. Before Revlon, Mohamed was the Associate Vice-president for Strategic Foresight and Innovation at L’Oréal USA. Mohamed received a Master’s degree in Physical Chemistry from Iowa State University and subsequently joined the New York City Police Department (NYPD) Crime Scene Laboratory, where he became a narcotics expert and managed the intoxicated driver unit before he pursued a career in Cosmetic Chemistry. For the last fifteen years, Omer has focused on product development, trends, and innovation, and assumed various roles in companies such as Colgate-Palmolive, Unilever, Mintel, and L’Oréal, where he helped develop a range of innovative products across multiple categories. Mohamed is an active member of the NYSCC where he serves on the Scientific Committee and was Chair of the Open Innovation Symposium. _____________________________________________

The Essential Steps to Becoming a Global Halal Certified Ingredient Supplier – John Gormley

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he decision to become a global ingredient supplier that achieves and maintains a halal certification is the first essential step in this process and one that should not be made lightly. Our company decided to be proactive in getting certified and to lead in this area. At the start of this project, we were not aware of any other U.S. cosmetic ingredient company being certified, so we had no precedent to follow.

Our research indicated both a business and social benefit to acquiring certifications to meet demand in (Continued on page 12)

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Cosmetics in the Middle East: A Regulatory Perspective

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predominantly Muslim communities around the globe. Our firm selected almost 400 products comprised of over 200 unique ingredients for certification, so organization of the data set and working with the auditor was a daunting task. Development of mutual trust is paramount as the auditor is provided many details of key internal operations. There are significant costs involved and some costs cannot be predicted. For instance, depending on feedstocks, you may have to reformulate ingredients that are not compatible with the rules.

The entire process requires support at the highest level of the company and will unexpectedly reveal many levels of challenges (internal and external) that need to be worked through in order to achieve a successful certification. As a U.S. based company, the act of finding a local halal certifier with global approvals was not a simple task and we suddenly were in the position of first auditing the auditors. My presentation will address several pros and cons in the selection process and the challenges of data collection, followed by some lessons from the audit process. Overall, achieving halal certification is an important step towards supporting a diverse global cosmetic community as they ask to be supported. This presentation is especially aimed to those about to start on this certification journey. n John

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Gormley

John is currently Director, Global Regulatory Affairs and New Chemistry Business Development at Grant Industries Inc. He obtained a B.S. in Chemistry from Rutgers University and an M.S. Chemistry/Biochemistry from Stevens Institute of Technology.

John has spent 32 years working in applied industrial chemistry as a regulatory specialist, inventor, and project manager. He has been issued a number of patents resulting in several commercially successful products on the market. John is experienced in chemistry and mentors talented individuals and teams to effectively yield results. During his career, he has worked at various important corporations in the personal care industry including ICI/Uniquema, Mona Industries, National Starch and Chemical, and Unilever Research USA. _____________________________________________

Story of Maya Cosmetics – Javed Younis and Bilal Saeed

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aya Cosmetics was created to solve a significant barrier preventing many consumers from wearing nail polish: the “halal” aspect (or lack thereof). This need was witnessed within the founders’ own families and close friends, and thus formed the impetus behind the product and company. Creating a halal-certified product translated into several key benefits, assisting a wide array of consumers. Maya nail polish is breathable, vegan, and 9-Free (i.e. free of 9 common toxins found in mainstream cosmetics), among other significant attributes. Maya Cosmetics is one of the first companies to have such a nail polish available in the market, and has created a reputation that can be trusted amongst the targeted clientele. Maya’s nail polish is certified by several large regulatory and scientific bodies, appealing to a wide spectrum of consumers. Maya is currently available in over 30 countries.

n Javed Younis

Mr. Younis was born and raised in the United Kingdom of Pakistani parentage.

He received his undergraduate degree from Northern Illinois University and went on to spend the next 20+ years in the healthcare and personal care markets. In that time, he has built distributor relationships around the world that have remained loyal throughout the decades. Mr. Younis along with business partner, Bilal Saeed, cofounded Maya Cosmetics in the spring of 2016. Maya was the first company to launch halal-certified nail polish that is made in the U.S. The company has just completed two years in business and is currently available in 30+ countries. n Bilal

Saeed

Mr. Saeed was born and raised in Chicago, Illinois. He began his undergraduate studies at College of DuPage before transferring to the American University in Cairo (Egypt) to specialize in Middle Eastern Studies. Upon returning to the U.S., he went on to complete a Master’s in Project Management from Boston University, with a specialization in Business Marketing. Before creating Maya Cosmetics with Javed Younis, he worked with Younis in the personal care market, and currently co-manages a real estate investment firm.

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Story of SprinJene – Sayed Ibrahim

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prinJene NaturalR toothpaste is a brand name of Health and Natural Beauty USA Corp. It was founded

by Dr. Sayed Ibrahim in 2012 in a small laboratory in New Brunswick, NJ. The idea of SprinJene NaturalR oral care products is to disrupt the all-chemical toothpaste and provide a natural, safe, and effective toothpaste for consumers of all life styles. That is why the patented technology of SprinJene NaturalR was born, bursting the benefits of the amazing black seed oil. SprinJene is the only toothpaste in the world that is certified in the five categories of gluten-free, vegan, kosher, halal, and animal cruelty free. These certifications make SprinJene the politically and socially correct toothpaste for people with different life styles and needs.

n Sayed

Ibrahim, Ph.D.

Dr. Sayed Ibrahim is the CEO and Founder of Health and Natural Beauty USA Corp., a contract manufacturing company, and its subsidiary, SprinJene, a branded oral care company. Dr. Ibrahim started his career as a Liaison Officer for the British NGO Action Aide. He first worked in relief in Africa and then managed the International Procurement for the World Bank project. Dr. Ibrahim received his international procurement training at the International Law Institute (ILI) and Georgetown University. From there, he moved to Colgate-Palmolive, where he managed new technology, with a focus in oral care, from 1997-2007. At the same time, Dr. Ibrahim started his transportation enterprise in medical transportation in 2000, by acquiring 50% of Peace Invalid Coach. And in 2003, he started Mercy Transportation, which focused on School and Public Transportation.

In 2007, Dr. Ibrahim left his Senior Chemist position at Colgate-Palmolive to follow his dream of creating premium, handcrafted toothpastes. After years of vigorous scientific testing, SprinJene was born. All toothpastes feature Dr. Ibrahim’s patented formula of black seed oil and zinc, and are the only toothpastes in the world that boast the following five certifications: halal, kosher, cruelty-free, vegan, and gluten-free. _____________________________________________

Overview of GCC Regulation (GSO 1943/2016) and Regulatory Advocacy – George Bouboulis

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ulf Cooperation Council (GCC) consumers spend $9.3 billion on cosmetics and personal care products. The region also boasts one of the strongest growth rates in this sector in the world. The overall regulatory framework governing these products was finalized in 2016. This presentation will provide an overview of the GCC regulation (GSO 1943/2016) and how it compares with those of the European Union and other countries. The presenter will also offer insight into industry advocacy in the region and potential future regulatory challenges. n George

Bouboulis

George is an Associate Director with the Global Strategies department of the Personal Care Products Council (PCPC). His regional policy portfolio covers Europe, Middle East, and Africa. In this capacity, George has been responsible for industry advocacy for the overarching GSO framework for cosmetics (GSO 1943/2016), the GSO standard for cosmetic claims (GSO 2528/2016), and numerous in-country industry issues. Prior to joining PCPC, he worked on Capitol Hill, for a State advocacy firm in Massachusetts, at a management consulting firm, and for the European Commission Delegation in Athens, Greece. _____________________________________________

Halal Discussion Panel – Sayed Ibrahim, John Gormley, Bilal Saeed, and Mohamed Omer (Moderator)

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he Halal Panel will be comprised of professionals with different perspectives within the personal care industry, including oral care, nail care, and raw materials supply chain. Panel participants will share their stories about their work, company, and/or products in relation to halal. Panel members and attendees will interact in a Q&A format, moderated by Mohamed Omer, to learn more about processes, (Continued on page 14) challenges, and advantages as they relate to halal certification.

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Cosmetics in the Middle East: A Regulatory Perspective

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Professional Henna Tattoo

Send news of interest, guest editorials, and comments to Roger McMullen, Editor • E-mail: roger_mcmullen @fdu.edu

Receive a professional henna tattoo at the April 2018 NYSCC event. _____________________________________________

Event Location Explore the Liberty Science Center • 222 Jersey City Boulevard, Jersey City, NJ

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ttendees will have the option to explore the Liberty Science Center after the program ends for a discounted price. Please check out the links below to see what is currently being offered.

• Current exhibitions: https://lsc.org/explore/today • Current movies and planetarium shows: https://lsc.org/explore/planetarium-films-laser-shows

Registration Information Pre-registration cost/at door cost: • SCC members: $35/$70 • Non-SCC members: $70/$100 • Students: $10/$50 • Emeritus: $0/$10 To register, please visit the Events section of the NYSCC website: www.nyscc.org.

Employment Opportunities For complete ads please go to the NYSCC website: https://www.nyscc.org/employment-listings.html.

n Technical Sales – Cosmetic Ingredients IFC Solutions Linden, NJ

n Product Manager – Global Personal Care Elementis Specialties East Windsor, NJ n Regional Marketing Manager NA IFF-Lucas Meyer Cosmetics New York, NY n Formulation Chemist IL MAKIAGE New York, NY 14

n Sales Agent – Personal Care Bloomage Freada Biopharm USA Inc. n Laboratory Technician TRI-Princeton Princeton, NJ n Purchasing Manager Sozio Piscataway, NJ n Midwest Sales Representative EES Cosmetic Solutions Chicago, IL or Indianopolis, IN

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