6 minute read

CBN AND SLEEP WELLNESS

from Feb. 2021 — MD Leaf

by Northwest Leaf / Oregon Leaf / Alaska Leaf / Maryland Leaf / California Leaf / Northeast Leaf

from Feb. 2021 — MD Leaf, page 30

CONNOR’S COURAGE

CURIO WELLNESS’ INNOVATIONS CBN& sLEEP

Curio Wellness’Good Night Pulse Released Tablets are one of the first medical Cannabis products to hit the market specifically formulated to address chronic sleep conditions. While many current products are marketed as sleep aids, it is hard to determine exactly what about a given product makes it sleep specific. Indeed, many products out there are essentially just a generic THC product with a label on it that says something sleep-related, without any real rhyme or reason as to how it targets sleep. Good Night on the other hand is not generic and has been clinically validated as a product for sleep.

It is definitely true that THC helps with sleep symptoms, but it also helps with all symptoms under the therapeutic umbrella of the endocannabinoid system, so for a lot of patients using sleep products, it’s hit or miss as to whether or not they feel a true drowsy effect, or just general relief that leads to a better night’s sleep overall. Since both outcomes will work for a patient to varying degrees, this discrepancy in the market hasn’t been fully sussed out.

Curio, however, did notice and came in to fill the gap with a specifically formulated product designed to do one thing, and one thing only: help you get to sleep and stay asleep.

There are some sleep products that utilize CBN, a known soporific cannabinoid, or compounds like melatonin and valerian root, to snowball the entourage effect in the direction of sleep – but none of these products have done a good job at explaining the research (if any) that led them to formulate their products the way they did, which inevitably leaves the patient confused about what does and does not work for them.

For example, if a patient uses one product and finds that it does improve their sleep symptoms, and their local dispensary sells out of that particular product, it becomes very difficult to match a product from another company to achieve those same effects.

Or the opposite can happen, wherein a product doesn’t have anything but just a THC dosage, in which case a patient can choose virtually any product in the same dosage range/ product category for the cheapest price, eventually leading to a decline in overall quality in the market. The truth of the matter is that we all must develop our own Cannabis regimens catered to our own personal biochemical needs, and that has a lot to do with the product formulation itself, the dosage of the product, the tolerance and lifestyle of the patient, and the nuances of sleep-related disorders themselves.

Curio has addressed these gaps in knowledge with their Good Night Tablets in two major ways. First, they utilize Pulse Release Technology that allows for targeted dosages at targeted times to interact with the patient’s system, and second, they base all their formulation off independent third party sleep studies that mimic a clinical trial.

Curio relied on data around specific cannabinoid formulation ratios in relation to their target patient demographic, and specifically to the symptoms they intend to target, to provide a true sleep aid based on the latest Cannabis research, as well as their own independent third party research study.

The company partnered with SleepScore Labs to conduct an observational sleep study with 35 certified Maryland medical Cannabis patients with sleep disorders and their new Good Night Tablets. Their formulation is a 2:1 THC:CBN ratio with each tablet containing 10mg THC and 5mg CBN.

Participants completed a six-week comparative study, where for the first three weeks their sleep was monitored in accordance with their existing sleep routine, including any sleep aids they already used. In the second three weeks, patients replaced their routine with use of Good Night according to the independent study protocol.

Across all phases of the study, participants’ sleep was monitored via the SleepScore Max Device and the completion of self surveys via the SleepScore research app.

Participants were also required to stop using any other Cannabis product within three hours of bedtime, to avoid clouding the data while trialing the Good Night product.

The results were successful, and patients showed marked improvement in their objective sleep metrics when using Good Night Tablets as well as participant’s subjective feedback indicating improvement in overall sleep quality. For me, it’s in the staying asleep aspect that really helps this product stand out from the crowd. My rule for Cannabis is that if you get high enough, you will eventually get drowsy. But with all the Cannabis products and profiles out there that cause a drowsy high, none of them address the longevity of the high itself. Eventually your body will process all the cannabinoids and the effects will wear off, which translates to some sleep patients waking up in the middle of the night.

Indeed, a large portion of the sleep-affected community has tremendous difficulty staying asleep and gaining the benefit of a full night’s rest. Falling asleep may be difficult, but staying asleep is what prevents A large portion of many of us from reaching our REM sleep and achieving a well-rested body. Curio’s Pulse Release Technology enthe sleep-affected community sures that several hours after ingestion, a has tremendous second wave of effects enters the body to difficulty staying help keep the patient asleep. So by tak- asleep and gaining ing one dose, you are getting the initial drowsy effects to help you fall asleep, as well as a second targeted release of the the benefit of a full night’s rest. cannabinoids several hours after ingestion to help you stay asleep – greatly increasing the probability of a patient sleeping through the entire night.

Everything with Cannabis is dose-dependent around an individual’s tolerance, but once you know which dose works best for you, Curio Good Night Tablets promote an improved night’s sleep with science backed data, a differentiator from any other Cannabis sleep aid on the market.

I really appreciate when a company puts this much thought behind their formulation and takes the time to test it out before finalizing. Curio is setting an industry standard that other companies are sure to follow and they aren’t stopping there – look out for two new products coming out in 2021 that are targeted specifically for pain and digestive health, using similar observational studies!