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MSDI is a leading company in the dental industry.

Based in Israel, MSDI provides premium products at affordable prices to meet the high standard of the dental industry.

Contents: A

Bone Graft Hypro-Oss Sintbone

B

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Membranes Hypro-Sorb M

C

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Haemostatics Hypro-Sorb R Hypro-Sorb x

D

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Sutures PTFE Suture PGA-LA Rapid Sutures

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Bone Graft Hypro-Oss Hypro-Oss- a natural bovine bone substitution material with incorporated atelocollagen.

Hypro-Oss is used for the permanent filling or reconstruction of antiseptic bone defects.

Each granule consists of approximately 30% atelocollagen and 70% hydroxyapatite.

Grain size - 0.5 - 1 mm

Indications: • Sinus lift • Vertical and horizontal augmentation • Intraosseous defects • Peri-implant defects • Extraction sockets • Furcation defects • Filling of cysts • Periodontal defects

HV Spot WD Mag 20 kV 4.0 8.7 mm 500x

Det Sig ETD SE

Pressure -----20.0um---

Hypro-oss electron microscope view

Properties and advantages:

Hypro-Oss is produced with patented atelopeptidation and lyophilization technologies.

These result in the following important characteristics: 1 Native bovine bone graft composite for enhanced new bone formation 2 Telopeptide-free collagen components; non-immunogenic peptide 3 Acceleration of physiological tissue healing process 4 Protects grafting site from infection (bacteriostatic effect of atelocollagen) 5 Hydrophilic property: optimal cell adhesion and blood absorption 6 Capability to carry medication to the surgical site 7 Highest biocompatibility: absence of any foreign body response 8 Natural structures of collagen and hydroxyapatite due to lyophilization processing 9 Osteoinductive atelocollagen components and osteoconductive hydroxyapatite components 10 Native crystalline structure guarantees long-term dimensional stability 11 Powerful haemostatic effect of the atelocollagen that averts haematoma formation after surgical procedures.

These characteristics allow enhanced and consistent new bone formation, and per sistent integration between mature new formed bone and existing bone materials.

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Histology after 14 weeks

Histology after 4 weeks

Sintbone Sintbone - a synthetic bone graft filling material based on a copolymer of PLA/PGA (polyactic and polyglycholic acids).

Sintbone is a space maintainer permeable to cells and osteons and does not induce phenomena of rejection or phlogosis. Sintbone permits blood orginiating from bone tissue to penetrate it and be progressively and totally replaced by trabecular bone.

It is easy and safe to use, destined for the filling of bone cavities, natural or pathologic, which necessitate the regenerate of new bone. Available in three different forms for your convenience: Sponge, Powder and Gel. The 3 forms which may be used individually or in combination, permit placing the material in the best possible way and consequently there is a better integration with the tissues.

Sintbone is highly biocompatible and biologically tolerated and it is absorbed completely within 4-6 months.

SINTBONE Unit Weight Unit Volume

SPONGE (Block) 240 mg 0.86 ml

POWDER 500 mg 2 ml

GEL (Syringe) 500 mg 0.5 ml

Properties and advantages: • Low density, guarantees a total absorption time from 4 to 6 months.

• Completely substituted by mineralized newly formed bone.

• The only product that is available in 3 forms: Gel, Sponge and Powder.

• The spongy structure of SINTBONE does not create an obstacle to the advancement of the osteons which are absorbed in a physiological manner, favoring their solidification into bone tissue.

• All the subsequent biocompatibility studies, first in animals then in man, document that SINTBONE is extremely biocompatible.

• Risk Free – Zero risk from cross contamination (e.g. BSE, HBV, HIV).

• Doesn't require a membrane in most cases.

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FISIOGRAFT Sponge

FISIOGRAFT Gel

Magnification: 200x

Magnification: 200x

Magnification: 500x

Magnification: 500x

published in “Implantologia Orale (2003; 4:77-80)”, entitled “Biomaterials utilized in bone regeneration: histological results”, 6-8 months after the various space-maintainers had been grafted. The data expressed in the chart below, indicates that SINTBONE was shown to be the most absorbable material.

BIOCORAL BIO-OSS BIOGLASS DFDBA SINTBONE HYDROXYAPATITE AUTOLOGOUS BONE PEP-GEN P-15 CALCIUM SULFATE

Newly Formed Bone 42% 39% 40% 29% 43% 41% 42% 40% 48%

Medullary Spaces 40% 34% 43% 37% 56% 30% 40% 37% 39%

Residual Material 18% 27% 17% 34% 1% 31% 18% 23% 13%

The histological results confirm that SINTBONE has the characteristic of being the “ideal space maintainer”. Its centripetal and progressive erosion, up until when it is totally degraded, permits bone tissue to regenerate without any outside interference with the physiologic repair process.

Fisiograft The biopsies show mature cortical bone tissue with signs of remodeling in the apical spaces, while in the central portion, bone which is more trabecular in present.

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Bio-Oss Most of the biomaterial appears surrounded by neoformed bone, in particular the most peripheral areas, while, in the central zone, inside the lacunae aells with morphological characteristics different from those of osteocytes. Bio-oss shows a very low level of absorption.

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Atelocollagen - a name given to the collagen that has been freed from telopeptides which fulfill the function of antigenic determinants while preserving its quasi-crystalline structure, i.e., regularly arranged triple helical conformation. Assets of this material include the highest degree of biocompatibility, excellent tolerance by the live tissue and resorbability after implantation.

min 4

mg 80

Time of bleeding(min) Blood Loss(mg)

3

60

2

40

1

20

0

0 Hypro-Sorb (Atelocollagen)

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Thrombin

Oxidized cellulose

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Thromboplastin

Control

Membranes Hypro-Sorb M Hypro Sorb M - biphasic, bilayer membranes of pure, crystalline atelocollagen derived from bovine origin. The resorption process happens in two phases. During the first four to six weeks, Hypro Sorb M stays intact. Only after that time does resorption start. The membrane will be completely resorbed within six months.

The Hypro-Sorb M membranes are indicated for use in dental and maxillofacial surgery as well as implantology: • Sinus floor elevation • Segment growing of the alveolar tissue • Peri-implantitis • Furcation treatment • Maxillofacial surgery • Cystectomy • Periodontal surgery • Cleft lip and palate

Available in 3 sizes: 16 x 20 mm 22 x 32 mm 32 x 42 mm

Properties and Advantages: • Pure, crystalline atelocollagen type I – free of telopeptides.

• Highest degree of tissue biocompatibility with excellent wound healing characteristics.

• Quick adaptation to the defect due to its potent hydro philic properties.

• Reduced risk of dehiscence formation due to the texture and mild bacteriostatic effect of atelocollagen.

• Can be attached with pins and suturing material.

• Sufficiently long barrier function – membranes stay intact for the first six weeks.

• Naturally resorbable within six months.

• Long shelf life – safe and sterile for five years after pro duction.

• Consistent availability and safety.

• Reliable clinical results.

• Unmistakable rough and smooth sides.

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Haemostatics Hypro-Sorb R Hypro-Sorb R - is sterilie pure native crystalline bioabsorbable bovine atelocollagen.

Hypro-Sorb R is indicated for the control of capillary and parenchymatous bleeding in surgery, dentistry and traumatology, as well as an ancillary aid to other haemostatic techniques.

Properties and Advantages: • Highest degree of tissue biocompatibility with excellent wound healing characteristics.

• Resorbs spontaneously within two to four weeks.

• Usable in infected wounds or with medically compromised patients.

• It can also be used as resorbable cyst filling in surgery, stomatology and traumatology.

• Can be cut to size without loss of haemostatic properties.

• Long shelf life – safe and sterile for five years.

Available size: 20x25 mm, 6 pcs/box

Hypro-Sorb x Hypro-Sorb X - is a sterile bovine atelocollagen type I, non-cross linked that has been especially prepared, purified and chemically modificated utilizing a unique technology.

The material is biocompatible, apyrogenic, non-immunogenic, non-allergenic, supports the healing processes and preserving the alveolar ridge after tooth extraction.

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Available size: 6x10x20 mm con,10 pcs/box

Indications: • Haemostatic.

• Alveolar ridge preservation.

• Extraction socket.

• Fenestration defect.

• Furcation defects (class I-II).

• Intraosseous defects (1-3 walls).

Properties and Advantages: • Natural atelocollagen, 99.9% collagen type I free of telopeptide.

• The specially designed conus form presents an excellent atelo collagen type I three-dimen sional matrix for one formation after tooth extraction.

• Accelerated soft tissue healing.

• Highest degree of tissue biocompatibility.

• Potent haemostatic property.

• Resorbed within 2-4 weeks.

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Sutures PTFE Suture PTFE Suture - monofilament, biocompatible, non-absorbable threads for surgeries (Periodontal, Bone Graft and Implant Surgeries).

These PTFE sutures are an excellent choice for any periodontal, bone graft or implant surgery. Thanks to being completely non-absorbable and biologically inert, these sutures cause minimal inflammatory response in the moist environment of the oral cavity. They are soft and comfortable for the patients and have great handling properties and knot security for the doctor. The suture is undyed and contains no additives Manufactured from 100% polytetrafluoroethylene polymer (PTFE), PTFE has been shown in clinical trials to elicit minimal tissue reaction. The PTFE Suture is not absorbed or subject to weakening by tissue enzymes, and does not degrade in the presence of infection.

Each package contains 12 sterile sutures attached to a needle.

Applications: • Dental bone grafting • Soft tissue grafting • Implant surgery • Periodontal surgery • Ridge augmentation • Guided tissue regeneration (GTR)

Characteristics:

• Completely non-absorbable, 100% pure PTFE. • Monofilament; prevents bacterial wicking.

• Biologically inert and chemically non-reactive.

• High tensile strength; does not weaken when moistened.

• Decreased inflammation and faster wound repair.

• Soft; comfortable for patients.

• Great handling properties and knot security.

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Available in Reverse cutting 3/8 circle, 75cm suture length: 19mm needle length, thread size: 3/0 and 4/0.

16mm needle length, thread size: 4/0 and 5/0.

PGA-LA Rapid Sutures PGA-LA Rapid Sutures - absorbable, synthetic & sterile surgical suture.

The absorbable 100% polyglycolic acid sutures are braided and coated. PGA is a synthetic, undyed, sterile, surgical absorbable suture material, which consists of polymers of glycolic acid.

PGA Suture is intended for suturing of soft tissues and/or for imposing of ligatures. They are also widely used in ophthalmology and in other surgical procedures.

Each package contains 12 sterile sutures attached to a needle.

Available in Reverse cutting 3/8 circle, 75cm Suture length: 20mm needle length, thread size: 3/0 and 4/0.

The reverse cutting (RC) needles are all made of 300 series stainless steel wire, have smooth surface and excellent penetration capacity even when used in tough tissues. They are especially popular for dental implant and bone grafting procedures.

PTFE Suture NEEDLE BODY CROSS-SECTION

SUTURE LENGTH

NEEDLE DICRIPTION

NEEDLE LENGTH

Reverse cutting 3/8 circle

16mm

75cm

Reverse cutting 3/8 circle

19mm

75cm

APPROXIMATE USP SIZE 3/0

4/0

5/0

PGA-LA Rapid Suture NEEDLE DICRIPTION Reverse cutting 3/8 circle

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NEEDLE LENGTH

NEEDLE BODY CROSS-SECTION

20mm

SUTURE LENGTH 75cm

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APPROXIMATE USP SIZE 3/0

4/0

Address: Havradim 16, Israel 3679104

Tel: +972-52-846-0950 www.msdi-ltd.com All rights reserved

E-mail: marketing@msdi-ltd.com