Needle-Free Buccal Peptide Delivery: How It Works and Where NeoPep Fits
NeoPep Research | neopeplife.com
How buccal delivery works 1
2
3
4
5
Place
Release
Reach
Cross
Enter
Patch sits against the inner cheek
Formulation controls how the peptide becomes available
Peptide stays near the buccal mucosa
Peptide moves through the mucosal tissue
Peptide reaches systemic circulation
Unlike a swallowed peptide, it does not have to pass the stomach and intestines first, so initial GI exposure is reduced.
Buccal vs oral vs injectable Factor
Buccal
Swallowed oral
Injectable
Route
Through the cheek mucosa
Through the GI tract
Through injection
GI exposure
Reduced initial exposure
Direct exposure
Generally avoided
First-pass metabolism
Can reduce hepatic exposure
Can occur after absorption
Generally bypassed
Needle required
No
No
Yes
Bioavailability still depends on the peptide: size, structure, stability and permeability all matter.
5 benefits of buccal delivery 1
Needle-free
2
Reduced GI exposure
3
Less first-pass exposure
4
Controlled release
5
Formulation flexibility
No injection required
Formulation decides the outcome
Less contact with acid and enzymes
Can reduce the hepatic first-pass effect
Hydrogels and polymers shape release
Multilayer designs suit each peptide
Stability, controlled release and mucosal contact must work together for the peptide to cross the tissue.
The NeoPep patch platform TD-IntelGel™
Muco-SmartSeal®
Hydrogel-based tri-layer patch system
Keeps the patch in contact with the cheek
Stabilized peptide matrix Controlled trans-diffusion through the buccal membrane Cold manufacturing to preserve structure and potency
Maintains patch position Helps limit peptide loss into saliva Supports buccal absorption at the delivery site
What the 81% result means 100
81% TD-IntelGel buccal patch in PermeaPad testing. NeoPep Innovations internal testing.
80
81.0
60
40 32.0 20
0
1.0
2.0
2.0
1.0
3.0
4.0
In-vitro result only. It is not clinical bioavailability, which needs pharmacokinetic data from living subjects.
Thank You Building a peptide product? Talk to our team about the TD-IntelGel buccal delivery platform.
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