NC State Oncology Research

ONCOLOGY

CVMResearchOffice@ncsu.edu P: 919.513.6213

Matthew Breen Professor, Genomics

BS: University of Liverpool, UK PhD: University of Liverpool Research Interest: Investigating the role that spontaneous animal models play in genetic diseases, especially cancers. This research has primarily involved studies of cancers in purebred dogs, comparative genome mapping and the identification of genomic features in animal cancers that are suggestive of an ancestral mechanism of pathogenesis.

Contact Email: matthew_breen@ncsu.edu Office: 919-513-1467

Tracy Gieger Clinical Assistant Professor, Radiation Oncology

DVM: Louisiana State University Research Interest: Feline lymphoma and canine nasal cancer.

Diplomate: American College of Veterinary Radiology, Radiation Oncology.

Diplomate: American College of Veterinary Internal Medicine, Oncology and Small Animal Internal Medicine.

Clinical Specialty: Canine and feline medical and radiation oncology.

Contact Email: tracey_gieger@ncsu.edu Office: 919-513-6238

Paul Hess Professor, Pharmacology

BA: New Brunswick DVM: Mississippi State PhD: North Carolina State Research Interests: Development of T-Cell based immunotherapies for hematologic malignancies of the dog.

Diplomate: American College of Internal Veterinary Medicine, Small Animal Internal Medicine; Oncology.

Clinical Specialty: Hematologic cancers.

Contact Email: paul_hess@ncsu.edu Office: 919-513-6183

Joanne Intile Clinical Assistant Professor of Medical Oncology

BS: Hofstra University MS: Hofstra University DVM: Cornell University Research Interests: Clinical trials (lymphoma rescue, mast cell tumors, electrochemotherapy, osteosarcoma), educational methods for veterinary students, house officers, and pete owners, medical journalism.

Diplomate: American College Veterinary Internal Medicine, Oncology Contact Email: jlintile@ncsu.edu Office: 919-515-7042

Jennifer Luff Assistant Professor

BS: Cornell University VMD: University of Pennsylvania PhD: University of California at Davis Research Interest: My overall research program focuses on virally driven cancers in domestic animals, with particular interest in papillomavirus infection and squamous cell carcinoma. One of my research projects is focused on viral immunity and the interferon response in the skin. I am interested in learning the different innate immune pathways involved in viral recognition in canine keratinocytes, the target cell for papillomavirus infections, and the mechanisms behind how papillomaviruses can dampen the immune response to escape detection.

Contact Email: jaluff@ncsu.edu Office: 919-513-8009

Christopher Mariani Assistant Professor, Medical Oncology

BSc: University of Guelph, Ontario DVM: University of Guelph, Ontario PhD: University of Florida, Gainesville Research Interest: Brain tumor characterization and therapy, epilepsy , inflammatory brain disease Diplomate: American College of Veterinary Internal Medicine, Neurology Clinical Specialty: Neurology Contact Email: Chris_mariani@ncsu.edu Office: 919-513-0302

Michael Mastromauro Assistant Professor, Medical Oncology

DVM: Cornell University Research Interest: Clinically focused with primary interest in clinical trials and tumors of special interest including lymphoma, multiple myeloma, and osteosarcoma.

Clinical Specialty: Hematopoietic tumors, osteosarcoma and clinical trails Contact Email: mlmastro@ncsu.edu Office: 919-513-8274

Michael Nolan Assistant Professor, Radiation Oncology and Biology

BS: SUNY Stony Brook DVM: Virginia-Maryland PhD: Colorado State Univeristy Research Interest: Developmental therapeutics (cancer drug development, particularly in companion animals with naturally-occurring cancer). Normal tissue complications after radiation therapy. Cancer and cancer treatments associated pain.

Diplomate: American College Veterinary Radiology Clinical Specialty: Veterinary radiation Oncology Contact Email: Michael_nolan@ncsu.edu Office: 919-513-6487

Marcelo Rodriguez-Puebla Associate Professor, Cancer Biology

MSc: University of Buenos Aires PhD: University of Buenos Aires Research Interests: Cell cycle deregulation in human cancer. The overall goal is to study the cell cycle regulation in mouse models that mimic human cancer. Our interest are to determine: 1) How deregulation of the cell-cycle controllers CDKs (cyclin-dependent kinases) affect tumor initiation and malignant progression.

2) Define the molecular mechanisms governing gene expression upon CDK/DNA interaction.

3) How the core of the cell-cycle responds during tumor initiation in epithelial cells and the role of epidermal stem cells.

Contact Email: marcelo_rodriguez-puebla@ncsu.edu Office: 919-515-7409

Steven Suter Associate Professor of Medical Oncology & Medical Director of the Canine Bone Marrow Transplant Unit

BS: University of Pennsylvania Education MS: New York Medical College PhD: University of Pennsylvania Research Interests: Understanding the molecular underpinnings of canine hematologic malignancies using a variety of sophisticated “genomics� techniques such as qRT-PCR, gene expression profiling, epigenetic profiling, RNAseq, and GWAS studies. The laboratory also houses the vast majority of published canine lymphoid cell lines which we use for a variety of cell cytotoxicity studies to evaluate novel therapeutics. Finally, the laboratory houses the Canine/Feline Oncology Diagnostic Laboratory which offers a variety of PCR-based diagnostic tests for both NCSU CVM and referring veterinarians.

Clinical Specialties: Diagnosis and treatment of canine and feline cancer. Canine bone marrow transplantation. Apheresis procedures such as therapeutic plasma exchange, leukoreductions, mononuclear cell collections, plateletpheresis.

Contact Email: steven_suter@ncsu.edu Office: 919-513-0813

Laurianne Van Landeghem Assistant Professor

MS: University of Bordeaux, France PhD: University of Nantes, France Research Interest: My laboratory explores the impact of the molecular crosstalk of normal and cancer intestinal stem cells with enteric glial cells on gut physiology and carcinogenesis. We have a unique dual expertise in enteric glia and intestinal stem cell biology that permits us to study in vivo, ex vivo and in vitro how glia regulates stemness in health and diseases with a special emphasis on cancer. A better understanding of the molecules that regulate stem cell functions is likely to help the development of innovative therapies aiming to stimulate healthy intestinal stem cells to promote regeneration or block cancer stem cells to limit colorectal cancer relapse and metastasis.

Contact Email: lcvanlan@ncsu.edu Office: 919-513-6801

Hiroto Yoshikawa Assistant Professor

DVM: Gifu University, Japan PhD: Colorado State University Research Interests: Radiation biology, cancer biology, molecular mechanisms in relation to resistance to radiation damage, cancer stem cells and multimodal targeted therapy.

Diplomate: American College of Veterinary Radiology, Radiation Oncology Clinical Specialty: Radiation therapy for veterinary patients; Sterotatic radiation therapy, conventional fractionated radiation therapy for many different body locations, with definitive and palliative intent treatment.

Contact Email: hyoshik@ncsu.edu Office: 919-513-6988

ABOUT THE COLLEGE OF VETERINARY MEDICINE

Ranked third in the nation by U.S. News & World Report, NC State’s College of Veterinary Medicine is a driving force in both animal and human health and a global center of medical excellence.

Our world-leading faculty and clinicians are at the forefront of interdisciplinary biomedical innovation, conducting solution-driven research that defines the interconnection between animal and human health.

Our extensive partnerships with business, industry and government build a culture of collaboration that helps solve today’s most pressing health challenges. As the national leader in experiential teaching and learning, we are training the next generation of skilled, compassionate veterinary health professionals equipped to serve the global community.

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