MUSC Catalyst

March 29, 2013

MEDICAL UNIVERSITY of SOUTH CAROLINA

Vol. 31, No. 31

Inside TAKE TIME TO SAY THANK YOU

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MUSC offers patients several ways to say thank you to physicians during National Doctors’ Day, March 30.

T-DM1 RECEIVES FDA APPROVAL

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Advanced breast cancer patients have a new treatment option with Kadcyla, formerly known as T-DM1 during its development phase.

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Meet Daryl

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News Center

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Classified ads

T H E C ATA LY S T ONLINE

http://www. musc.edu/ catalyst

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Dental volunteers offer free care

BY ANNALISE BAKER-WHITCOMB Public Relations

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USC dental students and professionals from the community volunteered together on March 1 during the Give Kids a Smile event for National Children’s Dental Health month.

The volunteers gave children free examinations, radiographs, cleanings and restorative treatment, as well as education

on dental hygiene. The event had about 60 appointments in addition to walk-in patients ranging from 3 to 16 years of age, according to Katherine Renne, DMD, an assistant professor in the College of Dental Medicine.

Renne said the event was a “huge community collaboration” of dental students from MUSC and Trident Technical College, MUSC dental faculty and other local professionals totaling 64 dental students and 25 dental professionals. The donated

dental treatment was valued at approximately $25,600.

For many children, this was their first experience at the dentist’s office. MUSC volunteers tried to make it fun by providing face painting and other activities. Amy Fisher said her youngest daughter, 3-year-old Brennan, is “scared of all big chairs, especially in a doctor’s office,” but was calmed by how friendly the dental students were who

See Dental on page 8

2 THE CATALYST, March 29, 2013

1ST FRANKLIN FINANCIAL HELPS MUSC

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Employee Wellness

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tatistics show that one in two men and one in three women are at risk for heart disease, and research shows that poor lifestyle is a major contributor.

Taking a walk each day can greatly help. ! It’s easy – walking costs nothing to get started. It doesn’t require any memberships or equipment, and it has the lowest dropout rate of any type of exercise. ! It works – studies show that for every hour of walking, life expectancy may increase by two hours, and walking for as few as 30 minutes a day provides heart health benefits. ! It’s good for business – physically active people save $500 a year in health care costs. Fitness programs can reduce employer health care costs by 20 to 55

Editorial of fice MUSC Office of Public Relations 135 Cannon Street, Suite 403C, Charleston, SC 29425.

843-792-4107 Fax: 843-792-6723 Editor: Kim Draughn catalyst@musc.edu Catalyst staff: Cindy Abole, aboleca@musc.edu Ashley Barker, barkera@musc.edu

percent, absenteeism by 2 percent and increase productivity by 9 percent.

On April 3, MUSC will join companies, organizations and individuals across America by taking 30 minutes to walk and pledge to live heart-healthy lives. The MUSC Medical Mile is approximately one mile and will be led by President Ray Greenberg, M.D., Ph.D., and Pat Cawley, M.D., in support of Employee Wellness.

Participants should meet at noon at the Horseshoe and are encouraged to wear Heart Walk or “I heart” T-shirts, which will be available for purchase.

Free pedometers, bottled water and fruit will be available while supplies last. For information, email musc-empwell@musc. edu.

The Catalyst is published once a week.

Paid adver tisements, which do not represent an endorsement by MUSC or the State of South Carolina, are handled by Island Publications Inc., Moultrie News, 134 Columbus St., Charleston, S.C., 843-849-1778 or 843-958-7490. E-mail: sales@moultrienews.com.

U02= >E +'`'IBK>' ;E+>EB@4 ;KZ National Doctors’ Day, recognized each year on March 30, is a day to celebrate the contribution of physicians who serve the country by caring for its citizens.

U.S. News & World Report ranked MUSC the No. 1 hospital in South Carolina, recognizing 48 MUSC physicians from 24 specialty areas as “Top Doctors,” and Best Doctors Inc. recognized more than 270 MUSC physicians as Best Doctors.

Following are comments made to MUSC physicians from patients: “Dr. Walter Limehouse (Emergency Medicine) was professional and concerned to resolve my issue. Dr. Limehouse has a great bedside manner!”

“We thank Dr. Margaret Villers (OBGYN) for her calming/knowledgeable help in my labor experience. She was amazing!”

“Dr. Scott Bradley (surgery) and all of the members of the MUSC Children’s Heart Program, pleases accept our thanks for the work you do on behalf of “heart kids” across South Carolina. You are the best.”

“Our heartfelt thanks to Drs. Eric Powers (cardiology) and Robert Fenning (hematology) for their excellent care, patience and listening.”

“It was a sincere pleasure to have Dr. Robert Stroud (OB-GYN) as my attending physician. He was cheerful, positive and upbeat, and took the time to answer my questions. I feel blessed to have such a caring and dedicated doctor assigned to my care. He is an asset to his profession and MUSC.” “My Dr. Stuart Leon (General Surgery), is truly an outstanding surgeon in every respect.

He is caring and takes the time to ensure a patient’s needs are met. I have never left his office without knowing I received the very best of care possible.”

“Dr. Edwin Smith (Specialty Care West Ashley Rheumatology & Immunology) listens to what I have to say. I know he cares about me and will do everything he can to help me with my problems. I am confident that I get the best care available when I see Dr. Smith.”

“I have been so pleased with the care I have received from Drs. Gretchen Reinhart

WANT TO SAY THANK YOU? MUSC will host a Doctors’ Day social media campaign, where patients and their families can recognize doctors by posting comments on MUSC and MUSC Children’s Hospital Facebook, Twitter and community blog sites.

Twitter: Hashtag: #MUSCDoctorsDay; @MUSChealth; @MUSCkids Facebook: Facebook.com/ MUSCCharleston; Facebook.com/ MUSCkids Blog: MUSChealth.com/thanks and Robbie Conatser (Specialty Care West Ashley OB-GYN). I would recommend these wonderful doctors to anyone and everyone who would listen!”

“Dr. Shane Woolf (Specialty Care North Charleston Orthopaedic Surgery) is an excellent communicator and extremely compassionate, outstanding with both patient and patient's family.”

“Dr. Eric Lentsch (Specialty Care North Charleston Otolaryngology) is very approachable, kind and professional. Dr. Lentsch had the best bedside manner of any doctor I have ever seen.”

“I would highly recommend my physician, Dr. Paul Underwood (East Cooper Women’s Center). In addition to his medical expertise, he was personable and compassionate.”

“It was the incredible team work of my MUSC doctors, nurses, lab technicians, assistants and staff who I refer to as my MUSC family that I celebrate today and every day. My family includes Drs. Robert Stuart (hematology/oncology), William McKibbin (orthopaedic surgery), Jeffrey Akhtar (Carolina Family Care), Karim Tazi (hematology/oncology), Chelsea Rainwater (hematology/oncology), Megan Baker (surgery), Toya Pound (OB-GYN), and all the pathologists, radiologists and cardiologists whom I have never met but have worked on my case. You have truly ‘Changed What’s Possible’ for me and my family.”

THE CATALYST, March 29, 2013 3

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BY ASHLEY BARKER Public Relations

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new drug is on the market that has fewer side effects and works better than prior standard treatments for advanced breast cancer patients.

The Food and Drug Administration recently approved the use of Kadcyla, which was known as T-DM1 during its development phase, for patients who have HER2-amplified metastatic breast cancer and who have progressed beyond standard therapies.

The “smart” new treatment links a toxin to a monoclonal antibody against the gene HER2 so that HER2-amplified cancer cells are destroyed in a twostage attack. T-DM1 attaches to the cancer cell and inhibits growth signals through HER2. Then the drug is internalized and the toxin is released to kill the cancer cell.

T-DM1 delivers a killing agent only to the cancer cells that express HER2, a gene found in 15 - 20 percent of breast cancers, according to Rita Kramer, M.D., breast oncologist and associate professor in the MUSC Division of Hematology and Oncology. Previous treatment strategies involved asking patients to take two different medications at the same time, one targeting HER2 and a second non-targeted chemotherapy.

?B'K@> EF+E`E$!@> ;BM 3!>K WBKG'BO `'%>O ^!>" =K!>`!F U'F$`'BO 3MTMO F<B@' DBK+>!>!EF'BH X<)Z YEB>EFO 3MTMO +`!F!+K` F<B@' `'K)'BH KF) WK>"'B!F' YK``EBKFO 3MTMO %EBG'B @><)Z +EEB)!FK>EB %EB +`!F!+K` >B!K`@ K> YE``!F$@ =KF+'B ='F>'BM “T-DM1 patients have less diarrhea, less nausea, less soreness of the mouth and fewer side effects involving the hands and feet turning red, being tender and peeling,” Kramer said. “The cytotoxic chemotherapy is going more directly where it needs to go and is better at controlling the patient’s disease, shrinking the disease,

and extending the duration of time before the disease worsens, which helps the patient live longer.”

A clinical trial to research T-DM1, involving 991 patients at 213 centers in 26 countries, was conducted from February 2009 until October 2011. Half of the patients were given T-DM1 and the others received lapatinib and capecitabine, the previous standard of care. One of those patients was at MUSC in the care of the breast medical oncology team at Hollings Cancer Center. The team consisted of Kramer, Neal Christiansen, M.D., and Frank Brescia, M.D. “You have to be pretty brave to do this. Those women get the therapy, and they let us follow them along.

We look at what happens and compare the results of the new drug to the old drug. That’s what generates the data that allows the FDA to say this one is better than that one,” Kramer said. “MUSC contributed to getting this data. The women who went on the trial contributed to us getting that information.”

When someone has metastatic cancer and a cure is not available, Kramer said, the goals are to help the patient feel better and control the disease as long as possible. T-DM1 patients lived longer and lived better.

“That’s what this drug does. The patient might respond to one treatment, but then the disease learns

See Option on page 4

4 THE CATALYST, March 29, 2013

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BY ANNALISE BAKER-WHITCOMB Public Relations Less than a year after Willette Burnham, Ph.D., started at MUSC in 2006, her husband and mother died within nine days of each other. Burnham, who is the executive director of student programs, was amazed and encouraged by the outpouring of support from people within the MUSC community, many of whom she didn’t even know.

“I thought long and hard afterward about just retiring, and I would have done that if I had not seen this community respond to me and my family in that way,” said Burnham. Those tragic events and MUSC’s reaction to them solidified her decision to remain a part of the MUSC staff.

Since then, Burnham has made great strides in her work in student affairs and student diversity. Burnham stresses making MUSC a place where any person, regardless of their background, will feel welcome and part of the community.

One of Burnham’s most memorable achievements at MUSC was implementing a program for each first-year student, across all programs, to have a minimum of three hours of diversity training. She did this with the creation of the Office of Training and Intercultural Education and the help and commitment of all the colleges and deans, to stress the importance of diversity in a health care setting.

Burnham supervises all recognized-student organizations including the Student Government Association, which during her tenure has successfully initiated a smoke- and tobacco-free campus, and the inclusion of sexual orientation in MUSC’s admissions non-discrimination statement.

;BM .!``'>>' ?<BF"KG Since being a resident assistant in her own college dorm, Burnham has been heavily involved in student life, totaling more than three decades of service. A South Carolina native, Burnham started out working at Williamsburg Technical College and then moved on to The Citadel, the College of Charleston and eventually MUSC, always working in student affairs.

Burnham faced some challenges as a black woman in education during her tenure across several state institutions. She was often the only black woman and administrator in her area. Burnham said she fought

hard to be thought of as more than “the black woman in higher education.” She maneuvered through many of her barriers through strong networks, perseverance and commitment to her beliefs.

“Always make sure you treat people, regardless of their gender, their ethnicity, their upbringing, their experience in life, as you want to be treated. I think that if you approach your work and your life in that way then that doesn’t leave any room for making people feel alienated and isolated, or alone.” Burnham said.

“I want to be in places where people generally want everyone in the community to be welcomed, and they make an extra effort to make sure that happens.”

When Burnham became the executive director of student programs at MUSC in 2006, she sought to create a more team-oriented work environment, instead of student affairs operating as separate entities.

Burnham, who has been working with the same core group of people, said teamwork and all-around dedication are what allows the group to function so efficiently and to grow every year.

“I just think I work with the best people in the world.

We’re like family,” she said.

Burnham loves to cook, especially comfort food and big family dinners. She has three adult children and three granddaughters who are 5 years old and under, all living in the Charleston area.

Burnham also loves to travel, hoping to see all she can in the United States. She hopes to take her grandchildren to all the places she wishes she could have gone at their age and works to leave them a proud legacy.

Editor’s note: In honor of National Women’s History Month, The Catalyst will feature women who are making a difference at MUSC.

OPTION Continued from Page Three to outsmart that drug. They might respond to the second treatment, but the disease will probably outsmart that one, too. So we keep trying different treatments,” Kramer said.

Progression-free survival is how long the disease is controlled with the one treatment before the drug must be switched to something else. Results from the trial, published in The New England Journal of Medicine, showed that the median progression-free survival was 9.6 months with T-DM1 versus 6.4 months with the other standard drugs,

as assessed by independent review. Investigators also found the median overall survival rate increased from 25.1 months for standard drugs to 30.9 months for T-DM1 users.

“The entire breast cancer team of physicians, nurse practitioners, nurses and clinical trial coordinators at Hollings Cancer Center is committed to improving therapies for their patients through clinical trials. The women who went on that trial made therapy better for all the women who came after them,” Kramer said. “We want the therapy to benefit

the women who go on the study, but it’s also benefitting all the women who come after them with this type of disease.”

Kadcyla can cause liver toxicity, heart toxicity, severe life-threatening birth defects and death, according to a warning from the FDA. The most common side effects from Kadcyla reported by patients were nausea, fatigue, pain in the muscles or joints, low levels of platelets in the blood, increased levels of liver enzymes, headache and constipation.

When T-DM1 was in the clinical trial stage it was only

available to patients in the study.

Since its FDA approval on Feb. 22, Kadcyla is now an option for advanced HER2amplified metastatic breast cancer patients and is already in use at MUSC. “This is our new secondline standard therapy,” Kramer said. “We translated this molecular biology finding to a new therapy. We’ve proven that it works, and now we can just get it off the pharmacy shelf. We’re excited because it’s a new therapy that works better and has less toxicity. This is a big advance.”

TEG!F''@ @E<$"> %EB %K+<`>Z @'B:!+' K^KB) Nominations for the MUSC Foundation’s Distinguished Faculty Service Award are being accepted. This award recognizes faculty members who have provided exceptional service and contributions in teaching, research, health care or public service.

In order to nominate someone, provide written justification to include a typed or printed narrative of no more than two single-spaced pages addressing the contributions made to MUSC. The deadline is April 22. Nominations should be submitted to Mark S. Sothmann, vice president for academic affairs and provost, 179 Ashley Avenue, Colcock Hall, MSC 002, MUSC.

THE CATALYST, March 29, 2013 5

MEET DARYL

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6 THE CATALYST, March 29, 2013

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BY CINDY ABOLE Public Relations Elizabeth “Betsy” Pilcher, DMD, is a female dentist striving to have it all.

This career practitioner, dental educator, mentor and single mother has pushed to achieve a successful worklife balance with her family and career responsibilities.

And, she’s doing well in making it work.

Throughout her career, Pilcher has made important strides at home and at work to achieve her goals.

This mother of two, one of which has special needs, managed to defy the odds and enjoy success in both areas.

Pilcher grew up around big cities along the East Coast. During summers she visited her mother’s family in Charleston. Her journey to dental school came by way of some adversity. Choosing to attend college in South Carolina, Pilcher was intent on going the pre-med route. She remembers being discouraged by a chemistry professor who told her that women should not be pursuing careers in medicine or dentistry. Not wasting any time, she immediately dropped that course and resumed classes with another instructor.

Pilcher thought dentistry would provide an ideal career without sacrificing family time. In 1977, she was one of seven women enrolled in a class of 56 dental students at MUSC. Women in Pilcher’s dental class banded together and became close. In 1970, only 1 percent of dental students in the U.S. were women, according to the American Dental Association.

“There were many perceptions about women in dentistry, such as women in dental school weren’t serious about their studies and not maximizing their training and education in the same way men were.

These perceptions have changed greatly over time,” said Pilcher. It was striving to balance work and family life that drove Pilcher to choose dentistry over medicine as her profession of choice. Since then, she has been committed to changing the perception of women in dentistry and in the workplace.

After graduating from dental school in 1981, Pilcher worked in public health for eight years and on Saturdays in a private dental practice. It was an ideal time for Pilcher to begin her family with the arrival of Christopher, born with Down syndrome in 1984, and Beth in 1987. In 1989, she returned to the dental school as a full-time instructor. For years she was the college’s sole full-time female faculty member, working in the Department of Crown & Bridge Dentistry, Division of Fixed Prosthodontics and later in the Department of Restorative Dentistry. For guidance early in her career, she networked and connected with women professionals outside of the dental school for mentoring support and career direction.

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“It was tough balancing life – first as a wife and dental student, and later as a mother and practitioner. There’s constantly a trade off to achieve balance.” ;BM ?'>@Z 6!`+"'B “It was tough balancing life – first as a wife and dental student, and later as a mother and practitioner.

There’s constantly a trade off to achieve balance,” said Pilcher, who chose to become active in the Charleston community as a mother of a child with disabilities. In 1991, she was among several parents who organized the Down Syndrome Association of the Lowcountry chapter, a local support group and resource for families.

She also was a local trailblazer for special education in area public schools. In 1989, Pilcher approached school administrators and advocated for her son and other children with special needs to receive their education in regular education classrooms through Charleston County Schools. “Chris was highly functional, and I knew the best place for him was to attend school in a regular education setting with the proper support and an adaptive curriculum,” she said.

Despite her early struggles, Pilcher feels happy with both her personal and career choices.

“I love working in a campus environment where there are lots of people, and I can watch and participate in the institution’s progress. I love teaching and working with faculty and preparing the next generation of dental educators. Working in academics provides the right amount of excitement and variety that’s different from

working in private practice,” Pilcher said.

The College of Dental Medicine consists of about 30 percent women faculty. Yet the ratio of women holding leadership roles in dental schools and managing state dental associations remains low. Pilcher believes this can be attributed to fewer qualified women professionals in the pipeline due to age, lack of experience and mentoring opportunities. “It takes mentoring to know when to promote one’s self.

Chances are women won’t do this on their own,” she said.

Pilcher is doing her share by leading the college’s mentoring efforts with both faculty and staff and serves as associate dean for Institutional Effectiveness. She’s also involved in leadership development efforts with the American Dental Education Association’s new Emerging Academic Leader’s program, mentoring eight junior dental faculty professionals in a peer group that offers training in negotiating skills, leadership development, goal setting, career building and advancement. Its goal is to prepare the next level of chairpersons, deans and administrators in academic medicine.

Within the past five years, Pilcher also has emerged as a leader sharing her skills as director of university strategic planning to help guide MUSC’s core missions and direct strategies for the future. She’s a graduate fellow of the Higher Education Resource Services Institute, ADEA Emerging Leaders Program, and Hedwig van Ameringen Executive Leadership in Academic Medicine Program for Women. She’s also involved in campus activities through the Women’s Scholars Initiative.

For now, Pilcher’s goals are to stay involved in academic leadership and strategic planning. “It’s a joy to come to work in the morning, blink and realize its 5 p.m. Time passes by quickly at work, and that translates to how much I enjoy my job and what I do. It’s exciting to watch and play a part in enacting change through the institution’s strategic plan initiatives and programs.

We have some great leaders on MUSC’s campus that I’ve been privileged to learn from. I’d like to continue working with them and others in many areas.”

Today, Pilcher’s children are grown and have lives of their own. She has more time to devote to her job through teaching, working in academic leadership and treating patients. She also enjoys travel and sailboat racing, a long-time hobby and passion.

“I find it exciting to be part of the university’s change.

At both the university and college level, I play a part in something that is very important and, to me, it’s very rewarding,” she said.

Editor’s note: In honor of National Women’s History Month, The Catalyst will feature women who are making a difference at MUSC.

THE CATALYST, March 29, 2013 7

NEWS CENTER — NEWS YOU CAN USE

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8 THE CATALYST, March 29, 2013

DENTAL

Continued from Page One

worked on her older sister, who had an earlier appointment.

Many of the children being treated were from underserved communities or were without dental insurance, said Renne. The volunteers emphasized follow-up appointments and continued dental care with parents, raising awareness about the need for year-round oral hygiene and care.

Candice Vinson, a third-year dental student at MUSC, said she was glad to have the opportunity to participate

and had a lot of fun. Vinson said the volunteers tried to get all the treatment done for each child on that day so that they would not have to make another appointment.

Chrystal Still, a mother of three, was transitioning between insurance plans and said the clinic happened at the “perfect time.” Still heard about the clinic through her daughter’s preschool, Bethany United Methodist. She said that because of this visit, she will most likely stay with MUSC for future dental care and described the entire experience as “extremely positive” for her children.

THE CATALYST, March 29, 2013 9

10 THE CATALYST, March 29, 2013

THE CATALYST, March 29, 2013 11

TO ADVERTISE IN THE CATALYST CALL 849-1778

12 THE CATALYST, March 29, 2013

WRAPPED IN HOPE - MADE WITH LOVE

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