2025 Moffitt Scientific Symposium

023

PROGRAM AGENDA Day 1 – Monday, May 12th, 2025 SRB Ted Couch Auditorium 4:00-5:00 PM

Moffitt Researcher of the Year lecture: Frederick Locke, MD

5:00-6:00 PM

Reception in SRB Atrium

Day 2 – Tuesday, May 13th, 2025 USF Marshall Student Center 8:00-9:00 AM

Registration, Breakfast & Poster Viewing in the Ballroom

9:00-9:10 AM

Welcome, Dr. Patrick Hwu, President, and CEO (Oval Theater)

9:10-9:50 AM

Featured Poster Presentations - Session I (Oval Theater) Moderator: Dr. Heather Owens Rojan Chimeh Rad (Gomes) “Aging drives TNBC lung metastasis dependency on FGFR-triggered metabolic reprogramming exposing an age-induced liability with therapeutic potential” Dr. Paige Aiello (Lee) “The Significance of Micrometastatic Axillary Disease after Neoadjuvant Chemotherapy in Breast Cancer” Dr. Evan Davis (Permuth) “Applying Large Language Models for Clinical Data Abstraction in Patients with Pancreatic Tumors” Dr. M A Masud (Anderson) “The role of tissue homeostasis in regulating basal cell carcinoma growth dynamics” Dr. Jeremy Frieling (Lynch) “Defining immune – stromal cell crosstalk during γδ CAR-T targeting of bone metastatic prostate tumors” Dr. Michelle Dugan (Zager) “A Comparison of Isolated Limb Infusion/Perfusion, Immune Checkpoint Inhibitors, and Intralesional Therapy as First-Line Treatment for Patients with Melanoma In-Transit Metastases” Dr. Charles Hoogland (D. Vidrine, J. Vidrine) “Baseline Sociodemographic, Smoking-Related, and Psychosocial Characteristics of Participants Recruited In-person vs. Online to a Smoking Cessation RCT Targeting People with Food Insecurity” Dr. Larissa Carvalho (K. Smalley “Defining the anti-tumor activity and immune affects of the RASMULTI(ON) inhibitor RMC-7977 in preclinical models of NRAS-mutant melanoma”

9:50-10:25 AM

Featured Poster Presentations - Session II (Oval Theater) Moderator: Dr. Mitchell Hayes Dr. Victor Gazivoda (Pimiento) “Prophylactic Robotic Assisted Total Gastrectomy is a safe practice in patients with hereditary diffuse gastric cancer ” Dr. Thales Nepomuceno (Monteiro) “CDK9 promotes DNA repair independently of its role in transcription”

Dr. Paulo Cilas Morais Lyra Junior (Goecks) “Optimizing Cancer Analyses with Best-Practices Machine Learning: A Web Application” Dr. Mariam Khaled (I. Smalley) “Multiomic analyses revealed disruptive immune and metabolic microenvironment in leptomeningeal disease” Dr. Jeffrey Johnson (Chahoud) “Updated Efficacy, Safety, and Correlative Analysis of a Phase II Trial in Metastatic Renal Cell Carcinoma with Short Course Pembrolizumab and High Dose IL-2” Dr. Xiaonan Xu (Karreth) “Novel mouse models recapitulate human uveal melanoma” Sabeen Ahmed (Rasool) “Multimodal AI for Accurate Prediction of Cancer Cachexia” 10:30-11:30 AM

Poster Session #1 (Ballroom) Odd Numbered Posters

11:00- 12:00 PM

Lunch (Ballroom)

11:30-12:30 PM

Poster Session #2 (Ballroom) Even Numbered Posters

12:30-1:20 PM

Oral Presentations – Session I (Oval Theater) Moderator: Dr. Daniel Antfolk Dr. Oyedolapo Anyawu (Gwede) “Baseline Data and Protocol for a Multibehavioral, Multilevel Intervention to Promote Concurrent Colorectal Cancer and Hepatitis C Screening Uptake among Patients Aged 45-75” Dr. Jianan Chen (Etame) “Integrative Transcriptomic and Single-Cell Analysis Reveals RNF135 as a Prognostic and Immunological Biomarker in Glioblastoma” Dr. Karla Feliciano Salva (Hansen) “Impact of Plasma Cell Burden (PCB) on Response and Survival in Relapsed/Refractory Multiple Myeloma (RRMM) Patients Receiving Standard of Care Idecabtagene Vicleucel (ide-cel)” Dr. Daniel Glazar (Brady-Nicholls) “Patient-reported symptoms correlate with early progression in non-small cell lung cancer treated with immune checkpoint inhibitors” Dr. Felicia Lazure (Gomes) “Aging drives the differential evolution of KRAS-driven lung adenocarcinoma towards a primitive stem-like state”

1:20-2:10 PM

Oral Presentations – Session II (Oval Theater) Moderator: Dr. Emily Keit Sarah Lulu (Hwu) “Intratumoral treatment of glioblastoma (GBM) with chimeric antigen receptor (CAR)T-cells expressing membrane-bound CD40L and activated by TLR agonism increases survival in syngeneic CT2A mouse model” Olabisi Osunmakinde (Ruffell) “Investigating cholesterol transfer between macrophages and prostate cancer cells” Dr. Samantha Seitter (Sinnamon) “Routine Staging Laparoscopy Prior to Neoadjuvant Therapy for Pancreatic Cancer Yields Significant Rate of Occult Metastatic Disease” Dr. Shahrzad Zamani (Schabath) “Analysis of sexual orientation and gender identity (SOGI) data reveals real-world cancer disparities among sexual and gender minorities (SGM) at the Moffitt Cancer Center” Dr. Md Muntasir Zitu (Rollison) “Large Language Models for Cancer Registry Coding Using RealWorld Moffitt Patient Data: Performance Evaluation and Error Analysis”

2:10-2:20 PM 2:20-2:30 PM

Patient Experience, Mary Margaret Braddock (Oval Theater) Best Poster Awards and Postdoc Poster Winner Announcement (Oval Theater)

TRANSPORTATION A Moffitt shuttle bus will be running a continuous route between Moffitt and the USF Marshall Center on Tuesday, May 13th from 7:30AM-3:00PM. You may also choose to walk or drive your personal vehicle if you have an appropriate USF parking permit.

Please see map below for exact shuttle stop locations.

Moderators and Oral/Featured Presenters will be provided with reserved parking in the Crescent Hall Parking Garage.

Shuttle stop =

POSTER MAP USF Marshall Student Center Ballroom

Featured Posters 001-015

MOFFITT SCIENTIFIC SYMPOSIUM FREQUENTLY ASKED QUESTIONS (FAQ) 1. Where is the Symposium located?

Monday, May 12th, 2025 - the Moffitt Researcher of the Year lecture will take place in the Stabile Research Building (SRB) Ted Couch Auditorium followed by a reception in the SRB Atrium.

Tuesday, May 13th, 2025 - all activities will be at the USF Marshall Student Center.

2. How can I get to the Marshall Center? Is there parking?

Reserved parking has been set aside for featured posters, oral presenters, committee members and speakers only. General attendees should walk to the Marshall Center or take the Moffitt shuttle which will be continuously running between Moffitt and the Marshall Center. Please review the transportation page in this guide for shuttle locations and times.

3. How do I know what poster session I can find certain presenters?

This guidebook shows the poster number for every presenter. The poster sessions are divided up by odd numbered posters (poster session #1) and even numbered posters (poster session #2).

4. Is there Wi-Fi available at the Symposium?

Wireless access is provided to guests of USF. Please follow these directions: 1.)

2.)

3.)

4.)

5.)

6.)

Open your list of wireless connections on your device and select “USF-Guest” Once you are connected, open your web browser and attempt to navigate to a website. You will automatically be redirected to the Guest Registration page On this page, select your preferred method of contact. Either “call me on my phone” or “send me a text message” You will receive a temporary access code within 5 minutes. Select the option “I have my access code”. You will need to agree to the acceptable use policy to continue Enter your mobile phone number and the registration code you received and hit “submit” You are now connected to the USF-Guest network. The registration will last for 24 hours and is valid for 1 device.

6. What will the food options be?

May 12th Reception: selection of hors d’oeuvres including vegetarian, vegan, and gluten free options with beer/wine bar May 13th Breakfast: assorted muffins, scones, danish, fresh fruit, coffee, juice, and tea May 13th Lunch: assorted sandwiches and wraps including vegan, vegetarian, and gluten free options.

Water and coffee will be available all day in the Ballroom on May 13th 7. How do I vote for the Best Poster awards?

All attendees will use the poster voting QR code located on the back of the attendee badge to vote for the best poster in each of the 5 poster categories. Please only vote once! The winners will be announced at the end of the Symposium.

8. Do I have to RSVP to attend the Symposium?

Submitting an RSVP is not absolutely required for attendance, but it is highly useful for the planning committee.

FEATURED POSTERS Presenter Chimeh, Rojan

Aiello, Paige Davis, Evan Masud, M A Frieling, Jeremy Dugan, Michelle

Hoogland, Charles

Carvalho, Larissa

Gazivoda, Victor Nepomuceno, Thales Morais Lyra Junior, Paulo Cilas Khaled, Mariam Johnson, Jeffrey

Xu, Xiaonan Ahmed, Sabeen

Title (mentor) Aging drives TNBC lung metastasis dependency on FGFR-triggered metabolic reprogramming exposing an age-induced liability with therapeutic potential (Gomes) The Significance of Micrometastatic Axillary Disease after Neoadjuvant Chemotherapy in Breast Cancer (Lee) Applying Large Language Models for Clinical Data Abstraction in Patients with Pancreatic Tumors (Permuth) The role of tissue homeostasis in regulating basal cell carcinoma growth dynamics (Anderson) Defining immune – stromal cell crosstalk during γδ CAR-T targeting of bone metastatic prostate tumors (Lynch) A Comparison of Isolated Limb Infusion/Perfusion, Immune Checkpoint Inhibitors, and Intralesional Therapy as First-Line Treatment for Patients with Melanoma In-Transit Metastases (Zager) Baseline Sociodemographic, Smoking-Related, and Psychosocial Characteristics of Participants Recruited In-person vs. Online to a Smoking Cessation RCT Targeting People with Food Insecurity (D. Vidrine, J. Vidrine) Defining the anti-tumor activity and immune affects of the RASMULTI(ON) inhibitor RMC-7977 in preclinical models of NRAS-mutant melanoma (K. Smalley) Prophylactic Robotic Assisted Total Gastrectomy is a safe practice in patients with hereditary diffuse gastric cancer (Pimiento) CDK9 promotes DNA repair independently of its role in transcription (Monteiro) Optimizing Cancer Analyses with Best-Practices Machine Learning: A Web Application (Goecks) Multiomic analyses revealed disruptive immune and metabolic microenvironment in leptomeningeal disease (I. Smalley) Updated Efficacy, Safety, and Correlative Analysis of a Phase II Trial in Metastatic Renal Cell Carcinoma with Short Course Pembrolizumab and High Dose IL-2 (Chahoud) Novel mouse models recapitulate human uveal melanoma (Karreth) Multimodal AI for Accurate Prediction of Cancer Cachexia (Rasool)

Poster # 001

002 003 004 005 006

007

008

009 010 011 012 013

014 015

BASIC SCIENCE POSTERS Listed alphabetically by last name Presenter Acevedo Acevedo, Suehelay Ackerman, Hayley Adhikary, Santanu

Beato, Francisca Bhattacherjee, Debojit Bishop, Ryan Bjornberg, Alicia Boucher, Justin Brunel, Alexia Caumont, Virgile Changizi, Shirin Chao, Ting Chen, Harry

Choudhury, Feroza Craig, Kendall Deshpande, Avani Drapela, Stanislav

Dumbali, Sandeep Emmons, Michael Fernandes, Vanessa Fidudusola, Fidara Galaktionova, Daria Gangadharan, Achintyan

Title (mentor) Metabolic reprogramming in 3D ex-vivo lung adenocarcinoma cancer models (Flores) TAp73 expression in the tumor microenvironment mediates antitumor immunity via regulation of lipid metabolism (Flores) Delta Np63/YAP regulates resistance to KRAS inhibitor via modulating tissue stiffness and metabolic alterations in lung adenocarcinoma (Flores) An Organoid Based T-Cell Cytotoxicity & Potency Assay (Permuth) Harnessing High-Throughput Chemical Proteomics for Tumor-Specific Target Discovery Using Fragment-Based Approaches (Rix) Spatial transcriptomic profiling of the immune landscape in multiple myeloma (Lynch) Cellular plasticity facilitates therapy resistance through enhancing adaptability (Marusyk) CAR T cells lacking CD3zeta can eliminate B cell lymphoma using NKG2D signaling (Guevara) TSPAN1/8-Dependent Mechanisms Maintain Dormancy and Therapy Resistance in Disseminated Breast Cancer Cells (Oskarsson) Non-cell autonomous interactions enhance plasticity-mediated therapy adaptation of lung adenocarcinoma cells (Marusyk) A Novel Photopolymerization Approach for Cellular Backpack Engineering in Immunotherapy (Dunne) Fragment probe library-based ligand screen for the identification of small molecules that decrease NRF2 activity (Jiang) Mechanisms of CMG Helicase Inhibition by the Retinoblastoma Protein Involve Direct CMG Binding and Potential Control of ATP Hydrolysis (Alexandrow) Tracing NRF2 dependent spatial metabolism during lung tumorigenesis (DeNicola) Synthesis of Novel CMG Helicase Inhibitors (CMGi) for Treatment of K-Ras-Driven Tumors (Alexandrow, N. Lawrence) Investigation of a novel lncRNA, TROLL-9, in breast cancer formation and progression (Flores) Microenvironment driven dynamic deposition of histone H3.3 controls entry and exit from dormancy in disseminated cancer cells (Gomes) Examining NNT’s Pleiotropic Regulation of Lung Cancer Mitochondria (Ward) Stress-induced HDAC8 reprogramming drives IL-11-mediated immune escape in melanoma (K. Smalley) Identification of new targets in small cell lung cancer using chemoproteomic-enabled fragment-based drug discovery (Rix) Therapeutic Potential of Solasodine in the Management of TripleNegative Breast Cancer (Solima) Unactivated Photoredox C–H Amination with Diazirine (Lopchuk) ALK1 as a regulatory of dendritic cell function (Ruffell)

Poster # 038 029 028

125 169 142 133 156 161 170 213 108 123

054 204 036 035

098 099 154 101 172 122

Georgei, Maria Hasan, Hasanain Hernandez, Diego

Huang, Yun Humphrey, Briley Ibrahim, Mohammed

Ilter, Didem Islam, Shamima Joseph, Manica Karanam, Laxmi Swetha Kashfi, Hossein

Kaur, Prerneet Kim, Yumi Knight, Andrew Krueger, Katharine Kumar, Pragya Lester, Daniel Li, Jie Lui, Ashley

Martin, Ryan Miner, Robert Miranda, Kaitlyn Napoli, Marco Nguyen, Loc

Mitochondrial Regulation of the Cytosolic Redox State Potentiates Ferroptosis (Ward) Non-invasive follicular thyroid neoplasms with TERT or TP53 mutations (Hernandez Prera) Impact of Translucent Sheet Bolus and Melanin Concentration on Recorded Optical Signal During Cherenkov Imaging in External Beam Radiation Therapy (Andreozzi) CRISPR screens identify GSR as a vulnerability for KEAP1/NRF2 mutant NSCLC (Jiang) Design and Synthesis of Small Molecule Inhibitors of ULK3 for Multiple Myeloma (N. Lawrence) Suppression of TNFα and IFNγ signaling are key molecular events in KRASG12C mutant cancer cells to confer therapeutic resistance to Sotorasib and promote immune evasion (Beg) Ferroptosis is a metabolic vulnerability of dormant disseminated breast cancer cells (Gomes) The E3 ubiquitin ligase Hectd3 controls immune colonic inflammation by restricting Myd88 signaling (Avram) Diabetes Mellitus Prevalence, Management, and Outcomes (Yedjou) Role of collagen I in the metabolic stress induced cancer cell dormancy and stemness (Nguyen) Quinolinic acid phosphoribosyl transferase (QPRT) expression is an essential liability of non-small cell lung cancer independently of its enzymatic function (Gomes) Metabolic shifts and Pathway alterations following Targeted AlphaParticle Therapy in Uveal Melanoma cells (Morse) PHGDH Supports Glutamine Levels and Promotes PDAC Progression (DeNicola) Chronic Glucocorticoid Exposure Protects Non-Small Cell Lung Cancer from Ferroptosis (Gomes) Mechanistic insights into RBFOX2-mediated alternative splicing events in pancreatic cancer progression and metastasis (Mann) Accelerated drug metabolism as a bona fide resistance mechanism to targeted therapies (Marusyk) Investigating the Lung Tumor Microenvironment in the naked mole rat (Kissil) The ectonucleotidase ENPP1 inhibits STING activation and anti-tumor immunity in BRCA-deficient breast cancer (Ruffell) RNA-Based Therapeutics to target the p53 pathway in high-grade serous ovarian cancer: TAp63-Regulated Oncogenic LncRNAs (TROLLs) as a novel therapeutic targets (Flores) Investigation of KEAP1-Independent Mechanisms of NRF2 Degradation in Non-Small Cell Lung Cancer (Jiang) Development of a novel, non-BCMA targeting CAR-T cell therapy for the treatment of multiple myeloma (Binning) Identifying therapeutic targets of delta Np63 driven metabolic reprogramming in Lung Squamous Cell Carcinoma (Flores) RNA-based therapeutics to target the p53 pathway in cancer (Flores) Actinium-225 targeted alpha-particle therapy causes cell-cycle DNA damage checkpoint arrest and programmed cell death in MC1R expressing uveal melanoma (Morse)

089 110 066

167 140 030

027 181 023 117 053

071 082 114 187 182 090 092 105

106 070 041 026 119

Nicolaci, Angelo Nyman, Karl Ochoa-Rios, Shaaron Olley, Maddison Palma, Flavio Raizada, Devesh Reddy, Megan Renatino Canevarolo, Rafael Riffas, Jamir Rix, Lily Rodriguez, Sheila Sakiyama, Marcelo Jun Silvane, Leonardo

Smallin, Marian Son, Juhyeon Soto-Vargas, Zulaida Sun, Le Jin Teixeira, Jennifer Tejero, Joanne Tian, Yijun Washington, Torus

Wright, Gabriela

Xiang, Shengyan Yadav, Vipin

Development of antibody-based strategies to target high-risk HPV E7 oncoprotein for cancer therapeutics (Binning) Single cell RNA-seq analysis of the aged murine multiple myeloma bone marrow microenvironment (Lynch) Identification and Characterization of GlycoRNAs in melanoma by Imaging Mass Spectrometry (Karreth) NRF2 Activation Sensitizes the Fe-S Cluster Synthesis Pathway to Iron Restriction (Ward) H3.1 oxidation promotes chromatin remodeling and cell phenotypic plasticity in breast cancer models (Bonini) Age-induced chronic accumulation of cortisol drives therapy resistance in lung cancer (Gomes) Different mitochondrial fitness landscapes drive differential evolution of lung adenocarcinoma (Gomes) Experimental Reconstruction of Breast Cancer Tumorigenesis and Metastasis (Silva) Uncoupling resistance and plasticity through models of acquired and intrinsic resistance (Marusyk) Novel therapeutic vulnerabilities of POU2F3 transcription factordriven small cell lung cancer (Rix) The Effect of T Cell Metabolism and Microenvironment (Rodriguez) Heavy metal exposures promote breast cancer chemoresistance via a novel mitochondria to nucleus ROS signaling (Bonini) Ablation of the transcription factor BCL11B in CD8+ TILs unleashes stemness, restricts exhaustion and improves memory to tumor (Avram) The Chromosome 19 MicroRNA Cluster Facilitates TIL-Based Immune Evasion in Human Cancers (Brohl) Targeting adaptive signaling in ALK and ROS1 fusion-positive nonsmall cell lung cancer (NSCLC) (Rix) MAFG-Driven HIF1A Stabilization: A Novel Mechanism Fueling Melanomagenesis (Karreth) Regulation of ATF4 by amino acid starvation in PDAC (DeNicola) Radiobiology of Ac-225 Alpha-Particle Radiotherapy Targeted to Uveal Melanoma: IR Stress Response (Morse) The transcobalamin receptor, CD320, is a therapeutic target for triple negative breast cancer (Gomes) Characterization of Native Allele Specific Methylation by Nanopore Adaptive Sampling Sequencing on Prostate Cancer Risk Loci (Wang) " BOWLS AREN’T JUST FOR CEREAL: Bowl-Ing for Breakthroughs, Scaling Down and Striking Out Lung Cancer with Silica Nanobowl Drug Delivery" (Morse) Expression of a cis-SAGe ADCK4-NUMBL fusion transcript accelerates proliferation in vitro, is prognostic of poor survival in lung adenocarcinoma patients and is elevated in the tumors of selfidentified Black patients (Cress) The Replicative CMG Helicase is a Druggable Vulnerability in Mutant K-Ras Driven Cancer Cells (Alexandrow) The Role of Melanin in Delayed Cyclobutane Pyrimidine Dimer Formation Following UV Exposure: Synthesis Pathway vs. Melanin Presence (Premi)

080 134 068 077 216 096 020 178 173 158 215 218 093

132 049 084 042 130 033 074 136

212

160 079

Yilmaz, Anyur Sanem

Matrix Metalloproteinase-Responsive Hydrogels for Targeting the Tumor Microenvironment (Dunne)

146

CLINICAL SCIENCE POSTERS Listed alphabetically by last name Presenter Aboujaoude, Michael Alzarkali, Omar

Ammad Ud Din, Mohammad

Amofa-Ho, Sam Arfa, Ahmed Avasthi, Kapil

Barnes, Anna Baumrucker, Camille Behne Sharma, Alexis Boozo, Mohammad Baraa

Cano, Carlos

Childers, Betzaira

Chiodo, Celina

Dave, Apeksha

Donovan, Eileen Elzaafarany, Osama Hammami, M Bakri Haney, Sean

Title (mentor) Relatlimab and Nivolumab with and without Radiation Therapy in the Management of Melanoma Brain Metastases (Ahmed) Progression-Free Survival and Overall Survival in Relapsed/Refractory T-cell Lymphoma patients on Chemotherapy vs Targeted Therapy (Saeed) The Real-World Safety and Tolerability of Pirtobrutinib among Patients with B cell lymphomas; a Single Center Experience (PinillaIbarz) Correlation between liver lesion biopsy cytopathology and histopathology reports – a retrospective review (Centeno) Complex Karyotype does not Worsen Survival in MDS/AML with inv(3)/t(3;3) (Hussaini) Development of a Multiplex PCR and NGS-Based Method for Detecting Cancer-Specific Splice Variants in Clear Cell Renal Cell Carcinoma (Wang) Comparison of Open and Percutaneous Instrumented Fixation for the Treatment of Spinal Metastases (Liu) Outcomes after Intratumoral Delivery of Immunotherapy in Breast Cancer (Lee) Incidence and Outcome of Pulmonary Hypertension in Myelofibrosis (Lee) A retrospective analysis of the incidence, clinical characteristics and outcomes of leptomeningeal disease in patients with metastatic melanoma (I. Smalley) Improvement of Diagnostic Accuracy in Breast Pathology, our Experience with Subspecialty Consensus Conference at a Cancer Center (Harper) An Evidence-Based Paradigm for Intraoperative Carcinoid Crisis Management: No Prophylaxis and a Bundle Treatment Protocol Improves Operative and Clinical Outcomes - A Single center experience with over 500 surgical cases (Anaya) Multi-institutional outcomes following chemotherapy, surgery, and locoregional and metastasis-directed radiation therapy for de novo oligometastatic breast cancer (Mills) "Missed" Rectal Organ Preservation with Pathologic Complete Response following Total Neoadjuvant Treatment: Why did they undergo mesorectal excision? (Felder) Role of Intraoperative Ablation in Patients Undergoing CurativeIntent Resection for Colorectal Liver Metastases (Denbo) Decoding NF2: Clinical and Genetic Insights from a Rare Disease Cohort (Moktari) Evaluating CAR-T cell therapy response in patients with Richter’s Transformation (Locke) Predictors of Survival Outcomes of Allogeneic Transplantation in Elderly Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome (Bejanyan)

Poster # 088 124

185

168 179 144

164 102 109 083

055

046

174

060

183 180 205 018

Harris, Nicole Jarallah, Osamah

Kale, Brandon

Khan, Anm Nazmul

Khant, Virika Khatri, Vaseem

Koo, Jihye Mazzacurati, Lucia Menon, Anjana Mitsakos, Anastasios

Nakashima, Justyn

Nasser, Nour Nazario, Gina Olabode, Kolade

Oliver, Mason Oseni, Saheed Ozoya, Oluwatobi Polce, Simran Poovathukaran Babu, Abida

Putra, Ilham

Post-Operative Impact of Negative Pressure Wound Therapy Following Oncoplastic Breast Surgery (Czerniecki) Safety And Efficacy of Concurrent and Maintenance Bruton Tyrosine Kinase Inhibitors (BTKi) for Patients with Mantle Cell Lymphoma (MCL) who Received Brexucabtagene Autoleucel (Brexu-Cel) (Mirza) NPM1-mutated myeloid neoplasms irrespective of blast count are associated with better outcomeswith acute myeloid leukemia treatment approach (Chan) Effects of Complement C3 Inhibition on Control of Malignant Effusions and on Neutrophil Phenotypes in Patients with Recurrent Metastatic Epithelial Ovarian Cancer: An Interim Analysis of an Ongoing Clinical Trial (NCT04919629) (Segal) Single and double strand break detection upon Ac-225-MTI201treatment in melanoma cells (Morse) Multi-institutional Report of Stereotactic Radiosurgery and Sacituzumab-Govitecan for Breast Cancer Brain Metastases (Ahmed) Impact of Contrast-Containing Bone Cement on Dose Calculation Accuracy in Radiation Therapy (Redler) Novel therapeutic approaches for recurrent high grade serous ovarian cancer (HGSOC) treatment (George) The effect of Bone Marrow Transplantation on Intraductal Papillary Mucinous Neoplasm progression (Luthra) A detailed evaluation of the clockwise anterior-to-posterior double isolation (CAP-DI) approach to portal lymphadenectomy for biliary tract cancers: lymph node yields, anatomical nodal distribution, and oncologic implications (Denbo) Clinical outcomes for extracranial oligometastatic renal cell carcinoma treated with stereotactic body radiotherapy – Institutional experience (Grass) PTV margin reduction for head and neck sequential boost treatments with online adaptive radiotherapy (Redler) Infrastructure expansion for an enduring Rapid Tissue Donation Program (RTD) (Schabath) Surgical outcomes and extrapolation to subsequent quality of life (QOL) for partial penectomy & glansectomy for penile squamous cell carcinoma (PSCC) (Johnstone) Delirium Prolonged Length of Hospital Stay in Patients After Cancer Surgery (Huang) Uncovering non-canonical tumor-specific antigens as novel immunotherapeutic targets for Melanoma and NSCLC (Hwu) Prevalence and Types of STAT5B Mutations in Myeloid Neoplasms from 2015 to 2024: A Single Center Experience (Zhang) Inpatient Radiotherapy: Insights for Hemostasis Consults (Johnstone) Low Risk of Relapse and Favorable Survival after Allogeneic Transplantation with Fludarabine and Melphalan Conditioning for Measurable Residual Acute Myeloid Leukemia (Bejanyan) Oncotype results of invasive lobular carcinoma; Two years’ experience in an academic cancer center (Zameel)

061 207

021

151

118 100

085 139 192 219

062

064 037 103

149 208 190 141 016

111

Rice, Komal Selvakumar, Sruthi

Shahzad, Moazzam Shannon, Adrienne

Strong, Erin

Tepper, Sarah Trivedi, Purvish Tuz Zahra, Fatima Whiting, Junmin

Wright, Corbin Wu, Qiong

Zervoudakis, Guston Zhao, Dekuang

Zhou, Zoe

Image-guided SmartClip Localization for Breast and Axillary Lesions: Placement and Outcomes Evaluation (Weinfurtner) Incidence of Major Adverse Cardiovascular Events with Venetoclax-based Therapy in Newly Diagnosed Acute Myeloid Leukemia (Lee) Outcomes of Neoadjuvant Therapy in Advanced Melanoma: A Systematic Review and Meta-Analysis (Jaglal) Survival Outcomes of Acral Lentiginous Melanoma in the Era of Modern Immune Checkpoint Inhibitor and Targeted Therapy (Perez) Patients Seeking Second Opinions at an NCI-Designated Comprehensive Cancer Center: A Population Segment with Unique Needs and Preferences (Anaya) Factors Related to Aseptic Loosening in Endoprosthetic Reconstruction of the Proximal Tibia (Lazarides) Novel voxel-based MRI risk score LADCT2 as a tool for prediction of prostate cancer (Yamoah) Real World Outcomes of Oral Azacitidine Maintenance Therapy forAcute Myeloid Leukemia: A Single Center Experience (Chan) Adverse event as informative biomarker in predicting clinical outcomes in colorectal cancer patient treated with immunotherapy (DT. Chen) Outcomes of patients with concurrent chronic lymphocytic leukemia and non-small cell lung carcinoma (Shafique) The reprogramming impact of SMAC-mimetic on glioblastoma stem cells and the immune tumor microenvironment evolution (Etame) Outcomes of Breast Cancer Metastases to the Appendicular Skeleton in the Setting of Current Treatment Modalities (Lazarides) Early Detection of Metastatic Progression by Circulating Tumor DNA in Patients Undergoing Bladder-preserving Trimodality Therapy (Grass) A Novel Patient-Derived 3D Microtumors Platform for Therapeutic Prediction in Ovarian Cancer (Sawyer, George)

031 166

032 017

210

034 052 044 075

067 025

198 022

024

POPULATION SCIENCE POSTERS Listed alphabetically by last name Presenter Adamus, Isabel

Amorrortu, Rossybelle

Antoine, Kiana Basinski, Toni

Berroa, Johnathan

Boxtha, Carol

Brockway, Samuel

Garcia, Melany

Gebert, Ryan

Geiss, Carley

Hernandez, Delilah Jones, Sarah

Lake, Paige

Matos, Madison

Title (mentor) Developing Literacy-Friendly Cancer Education Handouts for Hispanic/Latino Community Members: A Collaborative Approach (Christy) User-Centered Design of digital tools to enhance referral and enrollment of minority patients to cancer clinical trials (Vadaparampil) A feeding study examining the effects of diet-specific interventions on the gut microbiome (Carson) Development of an Educational Curriculum for Primary Care Providers Who Serve as the First Line of Defense Against Pancreatic Cancer in Underserved Communities (Permuth) An Iterative Approach to Updating an Educational Booklet to Promote Colorectal Cancer Screening and Hepatitis C Virus Screening (Gwede) My Portal CARES Interviews of Electronic Patient Portals Utilization Among Rural and Urban Setting Federally Qualified Health Centers (FQHC) in Central Florida (Meade) Baseline Sociodemographic, Smoking-Related, and Psychosocial Characteristics of Participants with Low vs. High Food Insecurity Enrolled in a Smoking Cessation RCT (D. Vidrine) Using the Socioecological Model for Formative Research to Develop and Refine Community Outreach and Digital Interventions to Enhance Diversity in Clinical Trials (Rollison) A Questionnaire-Based Cross-Sectional Survey of Cancer Patients and Healthy Participants in the Ponce Health Region of Puerto Rico (Cress) Assessing feasibility, appropriateness, and acceptability of digital patient journaling for qualitative data collection (Gonzalez) Preliminary use of an interactive decision aid educating patients about cancer clinical trials (Vadaparampil, Rollison) Associations between Wellness Plan Utilization, Treatment Engagement, and Smoking Abstinence: Secondary Analysis of an RCT Among Women with a History of Cervical Cancer (J. Vidrine) Application of a patient-centered communication (PCC) model in AYA cancer care: Exploring AYA patient and clinician perspectives on PCC and its role in addressing patient psychosocial well-being, fertility, and decision-making (Vadaparampil) Examining Organizational Capacity Pre/Post Implementation of Evidence-Based Interventions to Increase Adolescent Human Papillomavirus (HPV) Vaccination: Preliminary Results from the HPV MISTICS Trial (Vadaparampil)

Poster # 043

148

047 184

113

076

065

129

112

150

073 058

176

063

Murphy, Anastasia

Rivera, Madison Smith, Halle Tapia-Kwan, Elliott

Associations of social determinants of health with SARS-CoV-2 virus infection metrics and test-positivity among cancer patients evaluated at an NCI-Designated Cancer Center (Green) Advancing Tobacco Cessation in mHealth with TechnologyDriven Interventions: A Scoping Review (Vinci) Examining COVID-related distress among allogeneic hematopoietic stem cell transplant caregivers (Vinci) Developing a multi-pronged strategy to promote a multi-level intervention designed to increase patient diversity in clinical trials (Vadaparampil)

135

072 051 057

QUANTITATIVE SCIENCE POSTERS Listed alphabetically by last name Presenter Abudalou, Shatha Altinok, Oya Anderson, Hannah Barnett, Ari Barrios Ginart, Jorge Bhattacharya, Ranjini Cao, Biwei Carrasquilla, Alejandro Conahan, Piyawan

Duong, Thac Forero Pinto, Ana Froid, Matthew Gallaher, Jill Gatenbee, Chandler Hartsock, Iryna Havor, Phebe

Koutsoubis, Nikolas Kumar, Rikhil Li, Tao Makower, Gabriel Marzban, Sadegh Mizgalska, Katarzyna

Murthy, Amith

Title (mentor) Training Challenges of deep networks across readers in delineating Prostate gland anatomy (Balagurunathan) Radiomics with super-voxel segmentation improves HPV prediction accuracy significantly in oropharyngeal cancer (Schabath) Developing a virtual murine cohort for adoptive cell therapy in bladder cancer (Rejniak) Moment Informed Radiotherapy (West) A Question-Based Approach for Eligibility Representation in a PatientTrial Matching Chat Application (Eschrich) Resource Sharing Dynamics Shape Cancer Cell Foraging Strategies (Brown) B-STAR: Unifying Moffitt Research through a Centralized Tool Repository (Reich) Utilizing Machine Learning Models to Guide and Optimize Clinical Management of Cancer-Associated Compression Fractures (Tran) Using Explainable AI to Identify Key County-Level Factors for the Reduction of Blacks’ and Whites’ Late-Stage Lung Cancer Diagnosis and its associated disparities (Luo) Investigating ECM alternative splicing in solid tumors (Shaw) In silico modeling of cell-stroma mechanical interactions in DCIS progression (Rejniak) An Agent-Based Model of the Multiple Myeloma TME Provides Insights into TCE Resistance (Basanta) Identifying early progressors of adaptive therapy in metastatic castrate-sensitive prostate cancer (Anderson) Synergy between CAR T and the endogenous immune system is key to a complete response in large B cell lymphoma (Anderson) Improving Radiology Report Conciseness and Structure via Locally Run Large Language Models (Rasool) Circulating tumor DNA Dynamics as a Leading Indicating Biomarker for Time to Progression in HPV-associated Anal Squamous Cell Carcinoma (Brady-Nicholls) Harnessing Distributed Intelligence with Privacy Preservation: Federated Learning for the Early Detection of Lung Cancer (Rasool) Applying Shifted-Window Transformer Backbones to Cell Segmentation of Microscopy Images (El Naqa) A Tick-Tock model of tumor growth (Andor) A Multimodal AI Pipeline for BI-RADS Prediction: Addressing Bias and Class Imbalance in Breast Cancer Diagnosis (El Naqa) Mechanistic learning reveals stem cell state transitions as biomarkers for disease progression and therapy response in BCP-ALL (West) Mutations in drug binding sites: integrating computational chemistry and machine learning to understand mutation-induced resistance (Karolak) CLEAR-MATCH: Patient-centered, AI-powered clinical trial matching (Eschrich)

Poster # 188 059 107 186 147 045 214 206 097

126 056 193 165 127 050 175

137 200 128 197 152 091

145

Murugappan, Vishwa Obermayer, Alyssa Paz, Sheimy

Prabhakaran, Sandhya Pybus, Alyssa

Qi, Yunli Qiu, Junhao Scibilia, Kevin Robert Thompson, Zachery Tripathi, Aakash Upadhyaya, Diya Venkatesan, Kavya Waqas, Asim Xella, Agata

Molecular Characterization of Radiation Response Patterns Across Cancer Cell Lines (Shaw) Developing ShinyEvents: a generalizable framework for the analysis of longitudinal molecular and clinical data (Shaw) Incidence of DVT/PE in cancer patients undergoing endoscopy with general anesthesia: Leveraging ICD-Codes for data-efficient supervised fine-tuning of Transformers (El Naqa) Evolutionary immunotherapy in NSCLC: identifying optimal dosing strategies in TIL therapy using agent-based modeling (Anderson) Predicting patient response to immune checkpoint blockade therapy in multiple cancers using real-world clinical data and machine learning (Goecks) Learning Optimal Adaptive Therapies in Space and Time: Dynamic Threshold Therapy (Anderson) Accelerating Cancer Research with AI-Powered Software Agents (Goecks) Evolutionary therapy for metabolically heterogeneous tumors: The critical role of an acid-driven public bad (Anderson) An R Shiny Application for Analysis of Adverse Events and their Association with Clinical Outcomes in Clinical Trials (DT. Chen) HoneyBee: A Modular Framework for Embedding Multimodal Oncology Data (Rasool) Leveraging Patient-Reported Outcomes with Mathematical Modeling to Predict Tumor Volume Dynamics (Brady-Nicholls) Safety and Reliability of Large Language Models (LLMs) for Cancer Survivors - Preliminary Results (Rasool) Exploring Reasoning Capabilities of Large Language Models (LLMs) in Pathology (Schabath) ‘Go or grow’ phenotypic drift in an agent-based model of EpithelialTo-Mesenchymal Transformation (Anderson)

153 163 217

095 162

203 143 199 094 087 086 195 189 209

TRANSLATIONAL SCIENCE POSTERS Listed alphabetically by last name Presenter Abreu, Nickolas Arce Castro, Carolina Ayala-Navarro, Carlos

Balsay-Patel, Caitlyn

Carter, Michael Davis, Joshua

Fazili, Adnan

Hanzel, Sara Hendrick, Leah Hensley, Jacob Julia, Estefania Kunta, Vishaal Majumder, Anurima Neelature Sriramareddy, Sathya Obertopp, Nina Patel, Manishkumar

Phadke, Manali Shen, Daisy Solanki, Hitendra Singh

Varughese, Preethi

Title (mentor) FGD1 Splice Variants as Predictors of Brain and Bone Metastatic Organotropism in Clear Cell Renal Cell Carcinoma (Manley) Eco-evolutionary dynamics of breast cancer cell survival following chemotherapy (Gatenby) Appendiceal cancers display immunosuppressed microenvironment and mucin infiltration on multiplex immunofluorescence analysis (Dineen) Tumor antigen targeting type 1 conventional dendritic cells drive immune responses to eliminate metastasis initiating cancer cells (Czerniecki) Tumor Reactive T cells from the Cerebrospinal Fluid of Patients with Melanoma Leptomeningeal Disease (M-LMD) (Pilon-Thomas) SERTIN: Surfaceome Exporer with Refined Target Identification for Optimized Lead Candidate Nomination in a Cohort of Penile Cancer Patients (Shaw) Geospatial image analysis using multiplex immunofluorescence reveals tumor immune microenvironment spatial alteration that predict prognosis in penile cancer (Chahoud) Development of B7-H4 Targeted Chimeric Antigen Receptor (CAR) T-cell Therapy for Triple- Negative Breast Cancer (TNBC) (Hwu) Investigation of Patient-Derived Organoid Models as a System to Study Individualized Therapy for Colorectal Cancer (Permuth Heat-activated Drug Release from Microscale Hydrogels (Dunne) Engineering chimeric switch receptors with affinity tuned CD112R extracellular domain for targeting CD112 in solid tumors (Hwu) Ex vivo PI3K inhibition enhances T-cell memory and mitochondrial fitness for improved CAR T-cell therapy in CLL (Pinilla-Ibarz) Cell State Modulates the KRASG12C Proximal Proteome (Haura) The GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases (K. Smalley) Local single-dose radiation improves adoptive cell therapy with tumor infiltrating lymphocytes (Pilon-Thomas) Cell-free DNA Methylation-based Deconvolution and Fragmentomics Profiling for Cancer Detection using Short-Read Nanopore Sequencing (Wang) High CD8+ T cell TIM-3 expression predicts for sensitivity to TIM-3based triplet checkpoint inhibitor combinations (K. Smalley) Immune Profiling of Molecular Subtypes in Low-Grade Non-MuscleInvasive Bladder Cancer (Yu) RAS-GTP inhibition overcomes acquired resistance to KRASG12C inhibitors mediated by oncogenic and wildtype RAS activation in NSCLC preclinical models (Haura) Engineering Bispecific Nanobodies for the Detection of Breast Cancer Metastasis (Morse)

Poster # 120 194

048

019 155

196

202 211 039 177 201 157 121 081 040

159 115 104

078 131

Wang, Chao

Wong, Jodie

Adoptive cell therapy using tumor infiltrating lymphocytes induces impairment of tumor-infiltrating B cells in patient research biopsies (Creelan) Plasma cell-free DNA methylation-based prognosis in metastatic castrate-resistant prostate cancer progression (Wang)

138 116

2025 MOFFITT SCIENTIFIC SYMPOSIUM COMMITTEE Dr. Inna Smalley (Co-Chair) Dr. Evan Wuthrick (Co-Chair) Dr Yoga Balagurunathan Dr. Leidy Isenalumhe Dr. Zena Jameel Dr. Matthew Mills Dr. John Mullinax Dr. Thordur Oskarsson Dr. Ranjita Poudel Dr. Gage Redler Dr. Katarzyna Rejniak Dr. Michael Shafique Dr. Moazzam Shahzad Dr. Vani Simmons Dr. Erin Strong Dr. Lixin Wan Dr. Liang Wang

EVENT COORDINATORS Jill Fraley Angela Reagan Sarah Riordan