2024 Moffitt Scientific Symposium Guidebook

PROGRAM AGENDA Day 1 – Tuesday, May 7th, 2024 SRB Ted Couch Auditorium 4:00-5:00 PM

Moffitt Researcher of the Year lecture: Issam El-Naqa, PhD “Is Artificial Intelligence Real?”

5:00-6:00 PM

Reception in SRB Atrium

Day 2 – Wednesday, May 8th, 2024 USF Marshall Student Center 8:00-9:00 AM

Registration, Breakfast & Poster Viewing in the Ballroom

9:00-9:10 AM

Welcome, Dr. Patrick Hwu, President, and CEO (Oval Theater)

9:10-9:35 AM

Featured Poster Presentations - Session I (Oval Theater) Moderator: Dr. Thales Nepomuceno Aleena Boby “Hepatic and Overall Progression-Free Survival after Percutaneous Hepatic Perfusion as First-Line or Second-Line Therapy for Metastatic Uveal Melanoma” Elena Martinez Planes “IL-2-inducible T-cell kinase (ITK) is required for CD28 Y218 phosphorylation, an essential residue for IL-2 secretion and antitumor effect of CAR-T cells.”

Dr. Garima Pandey “Inhibition of endogenous wildtype RAS enhances JAK2 inhibitor therapy in preclinical models of myeloproliferative neoplasms” Helana Ghali “Tumor pigmentation in association with clinicopathological and immunological characteristics of primary melanomas” Hui-Ying Yang “Rates of Perceived Cognitive Impairment after the First Chemotherapy Infusion in a Large Sample of Cancer Patients” Dr. James McDonald “Tumor regression concordance between colon cancer metastasis to the liver treated with neoadjuvant chemotherapy and definitive resection” Kaizhen Wang “Non-canonical RNA binding of the MYBL2 transcription factor promotes melanoma” Maddison Olley “NRF2 Activation Sensitizes the Fe-S Cluster Synthesis Pathway to Iron Restriction”

9:35-10:00 AM

Featured Poster Presentations - Session II (Oval Theater) Moderator: Dr. Gage Redler Dr. Manishkumar Patel, “5hmc-sequencing identifies candidate genes in Puerto Rican Hispanic/Latino men with aggressive prostate cancer” Dr. Nadege Fackche “The Impact of Neighborhood Socioeconomic Deprivation on Overall Survival for Resectable Pancreatic Cancer Patients in Florida: An Incidence-Based Retrospective Cohort Study” Dr. Oscar Ospina “spatialGE: Empowering researchers to study the tumor microenvironment leveraging spatial transcriptomics”

Dr. Pompom Ghosh “Cell based high throughput screen of a diverse lead-like library identifies novel pharmacophores engaging the DDB1- CUL4 E3 ubiquitin ligase machinery, expanding the utility of DDB1 in targeted protein degradation.”

Dr. Richard Jacobson “Perioperative diet is associated with gut dysbiosis, antitumor immunity and tumor progression in a mouse model of metastatic colon cancer” Samantha Montoya “Provider Readiness for Implementation of Evidence-Based Intervention Strategies to Increase Colorectal Cancer Screening Uptake in Federally Qualified Health Centers (FQHCs) in Southwest Florida” Dr. Vural Tagal “A mathematical model revealing chemotherapy sensitivity as a function of cellular DNA content in triple-negative breast cancers” 10:00-11:30 AM

Poster Session #1 (Ballroom) Odd Numbered Posters

11:30- 12:30 PM

Lunch (Ballroom)

12:30-2:00 PM

Poster Session #2 (Ballroom) Even Numbered Posters

2:00-2:50 PM

Oral Presentations – Session I (Oval Theater) Moderator: Dr. Evan Wuthrick Dr. Bahram Dabiri “Mutations in TERT-p and NOTCH-1 are Associated with Better Survival in Penile Cancer” Dr. Hossein Kashfi “Quinolinic acid phosphoribosyl transferase (QPRT) expression is an essential liability of non-small cell lung cancer independently of its enzymatic function” Dr. James Yu “Clinical utility of circulating tumor DNA (ctDNA) in patients with early/resected biliary tract cancer (BTC)” Dr. Joshua Linscott “Tumor fraction and copy number burden from urinary cell-free tumor DNA (utDNA) predict minimal residual disease prior to repeat-transurethral resection in high-risk nonmuscle invasive bladder cancer (HR-NMIBC)” Dr. Kayode Olumoyin “An Early Determination of Patients Eligibility for a Bladder Cancer Immunotherapy using a Data Science Approach”

2:50-3:40 PM

Oral Presentations – Session II (Oval Theater) Moderator: Dr. Jong Park Dr. Piyawan Conahan “A Novel Approach towards an Accurate and Racially Unbiased Lung Cancer Screening Eligibility Mechanism from Real-World Data” Shiun Chang “Inhibition of FXR signaling in tumor-associated myeloid cells protects against melanoma progression” Sophie Moravec “Implementing Timely Germline Genetic Testing for Patients with Pancreatic Cancer via a Point-of-care Digital Education and Health Assessment Tool” Dr. Vivian Doerr “Impact of a Community-Based Weight Loss Intervention on Weight Loss, Physical Activity Ability, and Psychosocial Factors in African American Cancer Survivors and their Family Members” Dr. Yaakov Stern “Early transcriptional adaptation regulates duration of response to the KRAS G12C inhibitor sotorasib”

3:40-4:00 PM

Awards and Closing Remarks, Dr. Jong Park & Dr. Evan Wuthrick (Oval Theater)

TRANSPORTATION A Moffitt shuttle bus will be running a continuous route between Moffitt and the USF Marshall Center on Wednesday, May 8th from 7:30AM-4:30PM. You may also choose to walk or drive your personal vehicle if you have an appropriate USF parking permit.

Please see map below for exact shuttle stop locations.

Moderators and Oral/Featured Presenters will be provided with reserved parking in Lot 3.

Shuttle stop =

POSTER MAP USF Marshall Student Center Ballroom

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MOFFITT SCIENTIFIC SYMPOSIUM FREQUENTLY ASKED QUESTIONS (FAQ) 1. Where is the Symposium located?

Tuesday, May 7th, 2024 - the Moffitt Researcher of the Year lecture will take place in the Stabile Research Building (SRB) Ted Couch Auditorium followed by a reception in the SRB Atrium.

Wednesday, May 8th, 2024 - all activities will be at the USF Marshall Student Center.

2. Can I attend if I did not RSVP? Yes, we prefer that everyone RSVPs, but you can still attend if you forgot.

Link to RSVP: https://www.surveymonkey.com/r/HR5H6PL

3. How can I get to the Marshall Center? Is there parking?

Reserved parking has been set aside for featured posters, oral presenters, committee members and speakers only. General attendees should walk to the Marshall Center or take the Moffitt shuttle which will be continuously running between Moffitt and the Marshall Center. Please review the transportation page in this guide for shuttle locations and times.

4. How do I know what poster session I can find certain presenters?

This guidebook shows the poster number for every presenter. The poster sessions are divided up by odd numbered posters (poster session #1) and even numbered posters (poster session #2).

5. Is there Wi-Fi available at the Symposium?

Wireless access is provided to guests of USF. Please follow these directions: 1.)

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Open your list of wireless connections on your device and select “USF-Guest” Once you are connected, open your web browser and attempt to navigate to a website. You will automatically be redirected to the Guest Registration page On this page, select your preferred method of contact. Either “call me on my phone” or “send me a text message” You will receive a temporary access code within 5 minutes. Select the option “I have my access code”. You will need to agree to the acceptable use policy to continue

5.)

6.)

Enter your mobile phone number and the registration code you received and hit “submit” You are now connected to the USF-Guest network. The registration will last for 24 hours and is valid for 1 device.

6. What will the food options be?

May 7th Reception: selection of hors d’oeuvres including vegetarian, vegan, and gluten free options with beer/wine bar May 8th Breakfast: assorted muffins, scones, danish, fresh fruit, coffee, juice, and tea May 8th Lunch: assorted sandwiches and wraps including vegan, vegetarian, and gluten free options, garden salad, potato salad, assorted desserts, and fruit punch Water and coffee will be available all day in the Ballroom on May 8th 7. How do I vote for the People’s Choice award?

Everyone who attended the Symposium on May 8th (and signed in at the registration desk) will receive an electronic ballot via email on May 9th. Deadline to vote is Friday, May 10th by 5PM. The winner will be announced in Signals the week of May 13th. Featured Poster presenters and Oral presenters are not eligible for the People’s Choice award

FEATURED POSTERS Presenter Boby, Aleena

Martinez Planes, Elena

Pandey, Garima Ghali, Helana Yang, Hui-Ying McDonald, James

Wang, Kaizen Olley, Madison Patel, Manishkumar Fackche, Nadege

Ospina, Oscar Ghosh, Pompom

Jacobson, Richard

Montoya, Samantha

Tagal, Vural

Title (mentor) Hepatic and Overall Progression-Free Survival after Percutaneous Hepatic Perfusion as First-Line or Second-Line Therapy for Metastatic Uveal Melanoma (Zager) IL-2-inducible T-cell kinase (ITK) is required for CD28 Y218 phosphorylation, an essential residue for IL-2 secretion and antitumor effect of CAR-T cells (Abate-Daga) Inhibition of endogenous wildtype RAS enhances JAK2 inhibitor therapy in preclinical models of myeloproliferative neoplasms (Reuther) Tumor pigmentation in association with clinicopathological and immunological characteristics of primary melanomas (Karapetyan) Rates of Perceived Cognitive Impairment after the First Chemotherapy Infusion in a Large Sample of Cancer Patients (Jim) Tumor regression concordance between colon cancer metastasis to the liver treated with neoadjuvant chemotherapy and definitive resection (Felder) Non-canonical RNA binding of the MYBL2 transcription factor promotes melanoma (Karreth) NRF2 Activation Sensitizes the Fe-S Cluster Synthesis Pathway to Iron Restriction (Ward) 5hmc-sequencing identifies candidate genes in Puerto Rican Hispanic/Latino men with aggressive prostate cancer (L. Wang) The Impact of Neighborhood Socioeconomic Deprivation on Overall Survival for Resectable Pancreatic Cancer Patients in Florida: An Incidence-Based Retrospective Cohort Study (Anaya) spatialGE: Empowering researchers to study the tumor microenvironment leveraging spatial transcriptomics (X. Yu) Cell based high throughput screen of a diverse lead-like library identifies novel pharmacophores engaging the DDB1- CUL4 E3 ubiquitin ligase machinery, expanding the utility of DDB1 in targeted protein degradation (Duckett) Perioperative diet is associated with gut dysbiosis, antitumor immunity and tumor progression in a mouse model of metastatic colon cancer (Flem) Provider Readiness for Implementation of Evidence-Based Intervention Strategies to Increase Colorectal Cancer Screening Uptake in Federally Qualified Health Centers (FQHCs) in Southwest Florida (Gwede) A mathematical model revealing chemotherapy sensitivity as a function of cellular DNA content in triple-negative breast cancers (Andor)

Poster # 001

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BASIC SCIENCE POSTERS Listed alphabetically by last name Presenter Acevedo Acevedo, Suehelay

Title (mentor) Metabolic reprogramming in 3D ex-vivo lung adenocarcinoma cancer models (Flores) TAp73 expression in the tumor microenvironment mediates antitumor immunity via regulation of lipid metabolism (Flores) Delta Np63 drives resistance to KRAS G12C inhibitors altering the metabolic landscape in lung adenocarcinoma (Flores) Deciphering the link between Translational Dynamics and HLA-I Antigen Presentation (Jaeger) Evaluating Different Oncogenic KRASG12 Alleles at the Cellular and Molecular Levels in Non-Small Cell Lung Cancer (NSCLC) (Kissil)

Poster # 18

Redox Signaling Controls Drug Tolerance and Tumor Dormancy in Salivary Mucoepidermoid Carcinoma (Amelio) An FGFR-p53 developmental signaling axis drives progression of salivary cancer (Amelio)

32

Brunel, Alexia

Disseminated cancer cells express tetraspanins to promote chemoresistance in breast cancer (Oskarsson)

38

Bustos, Xiomar

Metabolic differences between gamma delta and alpha beta CAR T cells (Abate-Daga) Tumor Reactive T cells from the Cerebrospinal Fluid of Patients with Leptomeningeal Disease from Melanoma (Pilon-Thomas)

39

Stromal niche mediated positive ecological interaction between therapy-resistant and sensitive cells (Marusyk) Investigation of a novel lncRNA, TROLL-9, in breast cancer formation and progression (Flores) Dynamic deposition of histone H3.3 controls entry and exit from dormancy (Gomes) Identification of new targets in small cell lung cancer using chemoproteomic-enabled fragment-based drug discovery (Rix) Uncovering mechanisms of crosstalk between mesenchymal stem cells and γδ CAR-T cells to enhance immune targeting of bone metastatic prostate cancer (Lynch) Design and Synthesis of Chemical Probes to Investigate Small Molecule Inhibitors in ULK3 Driven Cancers (N. Lawrence) Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment immunotherapy response (Beg) RTK Signaling and WT RAS Activity as Vulnerabilities in Tumors with Acquired Resistance to GDP-state selective KRASG12C Inhibitors in Preclinical Models (Haura)

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Ackerman, Hayley Adhikary, Santanu Ali, Anika Amirifar, Parisa Bharambe, Harish

Billington, Julia

Carter, Michael Desai, Bina Deshpande, Avani Drapela, Stanislav Fernandes, Vanessa Frieling, Jeremy

Humphrey, Briley

Ibrahim, Mohammed

Imbody, Denis

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Islam, Shamima Jasani, Neel Khaled, Mariam

Kim, Yumi Krueger, Katharine

Kumar, Pragya Lazure, Felicia

Li, Jie Lockhart, John Lokhandwala, Jameela Londono, Nicole Lui, Ashley

Majumder, Anurima Mannan, Shahnewaj Manon, Chadourne Matar, Angelie Mecozzi, Nicol Miranda, Kaitlyn Napoli, Marco Nguy, Lindsey Nyman, Karl Onimus, Alexis Osunmakinde, Olabisi

The E3 ubiquitin ligase HECTD3 in the control of immune tumor microenvironment in colon cancer (Avram) MAPK pathway-mediated PHGDH induction establishes a metabolic vulnerability in melanoma (Karreth) Studying the efficacy of branched-chain keto acid-lowering therapy in managing neurological decline in preclinical leptomeningeal disease models (I. Smalley) PHGDH Promotes Glutamine Metabolism and Supports PDAC Progression (DeNicola) Deregulation of the RNA binding protein RBFOX2 promotes alternative splicing events driving pancreatic cancer progression (Mann) Cell extrinsic mechanisms of accelerated therapy resistance mediated by altered pharmacokinetics (Marusyk) Aging drives the differential evolution of KRAS-driven lung adenocarcinoma towards a primitive stem-like state that confers poor prognosis (Gomes) Targeting ENPP1 to boost anti-tumor immunity during PARP inhibition (Ruffell) Identification of metabolic shifts in lung adenocarcinoma progression using spatial metabolomics (Flores) Molecular mechanism of protein deglycation by Fructosamine-3kinase (Binning) Investigating Synergism Between Filanesib and Venetoclax in Ewing Sarcoma (Duckett) RNA Based Therapeutics to target the p53 pathway in cancer: TAp63Regulated Oncogenic LncRNAs (TROLLs) as novel therapeutic targets in cancer (Flores) Interrogating the proximal protein interactome of KRASG12C identifies novel therapeutic targets (Haura) Hectd3 regulates innate immune response through ubiquitination of MyD88 (Avram) The long non-coding RNA CDH3-AS1 regulates expression of the melanoma suppressor P-Cadherin (Karreth) Synthesis of novel PERK Inhibitors as Therapeutic Cancer Agents (N. Lawrence) circPMS1 promotes a pro-migratory phenotype in melanoma through non-canonical WNT pathway activation (Karreth) Investigating Pramlintide and MDM2 inhibition to modulate p53 family members in cutaneous squamous cell carcinoma (Flores) TAp63 and DeltaNp63 orchestrate the regulation of diverse biological processes by cooperating with distinct transcription factors (Flores) Establishing a platform for investigating PARP inhibitor sensitivity in PARP1 knockout cells (Monteiro) Dissecting the reciprocal effects of the aging bone stroma on multiple myeloma (Lynch) Taxane chemotherapy promotes response to immune checkpoint blockade through cGAS-STING activation and ER stress (Ruffell) Investigating cholesterol transfer between macrophages and prostate cancer cells (Ruffell)

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Prieto, Karol

Pramlintide decreases myeloid-derived suppressor cells during cutaneous squamous cell carcinoma treatment through the modulation of Myc (Tsai) Age-induced chronic accumulation of cortisol drives therapy resistance in lung cancer (Gomes) TCF12 downregulation promotes transcriptional reprogramming driving pancreatic cancer liver metastasis (Mann) Ex Vivo Mathematical Myeloma Advisor (EMMA) – a Clinical, Molecular, and Phenotypic Platform to Tailor Personalized Therapeutic Strategies for Multiple Myeloma (Silva) LonP1 Inhibition: A Novel Approach to Tackle Tumor-Associated Macrophages (Rodriguez) A novel model of tumor initiation in the naked mole-rat (Kissil) Deletion of BCL11B increases stemness and fitness of tumor infiltrating CD8+ T lymphocytes (Avram)

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Smallin, Marian

The Chromosome 19 MicroRNA Cluster Facilitates TIL Immune Evasion in Cancer (Brohl)

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Snedal, Sebastian

A novel T cell receptor targeting cancer testis antigen NY-ESO-1 (Abate-Daga) Polyphamacology mechanisms of dasatinib to treat RET-positive nonsmall cell lung cancer (Rix) Acetylation as a regulator of quinolinate phosphoribosyl transferase (QPRT) with consequences for lung cancer (Gomes) Collagen stabilization directs immune suppression in the head and neck squamous cell carcinoma hypoxic subtype (Amelio) Targeting NOS sensitizes the NRAS-mutant melanomas to MEK inhibition and induces CD8+ mediated anti-tumor immunity (Premi) Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells thereby suppressing anti-tumor immunity (Gomes) Chronic upregulation of glucocorticoid hormones triggers chromatin remodeling in NSCLC through dynamic regulation of Histone H3 chaperones (Gomes) Meningeal cells promote tumor growth and drug resistance in melanoma leptomeningeal metastasis through upregulation of SERPINA3 mediated pathway (I. Smalley) Development of the Cu-64-MTI-201 Companion PET Imaging Tracer for Ac-225-MTI-201 Targeted Alpha-Particle Therapy (Morse) Single Cell RNA Abseq analysis of head and neck squamous cell carcinoma treated with a CHK1/2 dual inhibitor (prexasertib) and a nucleoside analog (gemcitabine) reveals unique immune cell tumor infiltration (Duckett) Engineering a new mouse model to study Translational Dynamics and Antigen Presentation IN VIVO (Jaeger) Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function (Alexandrow) Characterizing the mechanism of uveal melanoma in vivo via novel mouse models (Karreth) Design and characterization of next generation, drug like sunscreen compounds (Premi)

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Raizada, Devesh Ranjouri, Mohammadreza Renatino Canevarolo, Rafael

Rocha Munguba, Leo Shepard, Alyssa Silvane, Leonardo

Son, Juhyeon Spegel, Júlia Srivastava, Sonal Srivastava, Jyoti Tejero, Joanne Traversa, Benito

Vallebuona, Ethan

Varughese, Preethi Walker-Mimms, Hannah

Weeden, Andrew Xiang, Shengyan

Xu, Xiaonan Yadav, Vipin Kumar

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Yoon, Sang Jun Zelenka, Tomas Zorro Manrique, Soraya

Mechanism and role of non-canonical cystathionine synthesis in cancer (DeNicola) Bcl11b regulates stemness, exhaustion and cytotoxicity in tumorinfiltrating CD8+ T cells (Avram) CRISPR-mediated metabolic reprograming of adoptively transferred CD8+ T cells via PDHB potentiates antitumor response (Hwu)

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CLINICAL SCIENCE POSTERS Listed alphabetically by last name Presenter Aboukheir Aboukheir, Aihab

Aflatooni, Shaliz Ammad Ud Din, Mohammad Avalos Hernandez, Sara Avasthi, Kapil Benyahia, Steven

Boozo, Baraa Boyd, Frank

Byrd, Clifton Carmella, Rachel

Childers, Betzaira Chitsaz, Mahsa

Clampitt, Bryan

Davaro, Elizabeth Detz, David Dohm, Ammoren

Domino, Joseph Drake, Justin

Title (mentor) Lymph Node Metastatic Pattern Following Robotic Lobectomy and Systematic Lymph Node Dissection in Non-Small Cell Lung Cancer (Freyaldenhoven) Isolated limb infusion for limb threatening sarcomas (Zager) Clinical Characteristics, Treatment Strategies, and Outcomes for CLL Patients with BTK Mutation; a single center study (Pinilla-Ibarz) Comparison of immunohistochemical stains for the evaluation of atypia in breast proliferative intraductal lesions (Rosa) Distinct Proteome Profiles in Plasma Exosomes of Lung and Prostate Cancer Patients (L. Wang) Evaluating Quality Outcomes after Implementation of an Inpatient Hospitalist Service for a Subset of Malignant Hematology Patients (Abdallah) Leptomeningeal Disease from Metastatic Melanoma - Insights from a Decade at the Moffitt Cancer Center (I. Smalley) Safety USHERSS: A Quality Improvement Initiative on Utilizing the Safety Huddle to Empower Residents as Safety Stewards: University of South Florida Pathology Residency Experience (Bajestani) Appropriateness of Acute Breast Symptom Recommendations Provided by ChatGPT (Ataya) Enhancing Stool Collection among Ostomized Patients: Tailored Instructions and Collaborative Strategies in a Cancer Research Setting (Siegel) Results of a Stakeholder Geriatric Surgery Survey at a Dedicated Cancer Hospital (Stefanou) SWI/SNF (SWItch/Sucrose Non-Fermentable) -related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4 (SMARCA4)-Deficient Undifferentiated Tumors: A Comprehensive Institutional Review (Bui) Correlations between lesion avidity, immune effector cellassociated neurotoxicity syndrome scoring, and fracture risk in patients with multiple myeloma undergoing chimeric antigen receptor T-cell therapy (Lazarides) Validation of Cytology Specimens for Next-Generation Sequencing: An Institutional Experience (Boyle) Feasibility of Electromagnetic Clip Bracketed Localization for Breast-Conserving Surgery (M. Lee) Clinical outcomes of melanoma brain metastases treated with nivolumab and ipilimumab alone versus nivolumab and ipilimumab with stereotactic radiosurgery (Ahmed) Carbon fiber-reinforced PEEK spinal instrumentation utilization to improve radiographic surveillance and radiation delivery (Tran) Gastrectomy for Patients with Gastric Cancer Peritoneal Metastases: Safety and Outcomes from an Initial Experience (Dineen)

Poster # 17

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Dugan, Michelle El Sayed, Bassel Farooq, Muhammad Flores, Kristen

Guske, Christopher Hanssen, Diego Hendrick, Leah

Huynh, Thien Huong

Jesin, Noel

Khadka, Monica

Khatri, Vaseem

Koo, Jihye Miller, Justin

Moriarty, Jacob Nakashima, Justyn

Peroza, John Peterson, John Rashid, Wasiq Saha, Aditi

Sarcar, Bhaswati

Isolated Limb Infusion as First, Second, or Third-Line Therapy for Melanoma with In-Transit Metastasis (Zager) Risk of kyphoplasty failure in the treatment of cancer associated compression fractures: A retrospective analysis (Tran) Gender Disparities in the National Institutes of Health Funding for Gastrointestinal Oncology (Jaglal) Development of Novel Disease-Specific Composite End Points of Toxicity-Free, Progression-Free Survival (TPFS) after Chimeric Antigen Receptor T-cell Therapy for patients with Large B-Cell Lymphoma and Multiple Myeloma (Lazaryan) Delays in Initiating First Line Bladder Sparing Therapy Portend Worse Oncologic Outcomes for BCG Unresponsive Patients (R. Li) Frailty and Malnutrition in Surgical Outcomes of Elderly Breast Cancer Patients (C. Lee) Sarcopenia After Neoadjuvant Radiation Negatively Impacts Length of Stay Following Resection of Retroperitoneal Sarcoma (Mullinax) Understanding the influence of chimeric antigen receptor T-cell therapy on fracture risk of patients with multiple myeloma (Lazarides) The Edmonton Symptom Assessment System (ESAS) And Postoperative Outcomes in Pancreatic Cancer Patients After Whipple Procedure: A Retrospective Study (Huang) Attitudes, emotions, and behaviors in response to receipt of lowmoderate penetrance genetic test results for melanoma/skin cancer risk (Kanetsky) Multi-Institutional Series of Tucatinib with Stereotactic Radiosurgery for HER2 Positive Breast Cancer Brain Metastases (Ahmed) Clinical feasibility of 6-sec CBCT for lung IGRT with various breathing patterns (Andreozzi) Preoperative Indicators of Non-Operative Mortality After Surgery for Renal Cell Carcinoma with Inferior Vena Cava Tumor Thrombus (Spiess) Development of a Theranostic Methodology to Perform Voxel Based Dosimetry for a Targeted Alpha Particle Therapy (Tichacek) Patterns of failure in patients with secondary CNS lymphoma in Relapsed/Refractory Large B-cell Lymphoma post CAR-T therapy (Figura) Targeting CDK12/13 overcomes resistance to KRASG12C inhibitors in lung cancer cells (Haura) A Retrospective Analysis Abdominal and Pelvic Neuroendocrine Tumors Treated with MRI-guided Radiotherapy (Hoffe) Intraoperative Ketamine Administration for Postoperative Depressive Symptoms in Pancreatic Cancer Patients (Huang) A novel composite endpoint of toxicity- and progression-free survival after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma (Lazaryan) KRAS copy number variation and mutant allele fractions predict in vitro response of PDX-derived human pancreatic cancer cell lines to KRASG12D inhibitor MRTX1133 (L. Wang)

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Shahzad, Moazzam Shannon, Adrienne

Thatikonda, Sowjanya

Thomas, David

Wright, Joshua Wright, Benjamin Wu, Qiong Yang, Wendy Zervoudakis, Guston

Geographic and Racial Disparities in Bi-Specific Antibodies Trials Access for Diffuse Large B-cell Lymphoma (Jaglal) Pathologic Response to Neoadjuvant Immunotherapy in DNA Mismatch Repair Protein-Deficient Gastroesophageal Cancers (Sinnamon) PV-10 triggers immunogenic cell death and anti-tumor immunity in head and neck squamous cell carcinoma via endoplasmic reticulum stress and autophagy (Chung) Hematopoietic Stem Cell Transplant Recipients requiring Continuous Renal Replacement Therapy during Pre-Engraftment are at High Mortality Risk (Baluch) Breast Biopsy Bleeding Outcomes for Patients on Antithrombotics (Ataya) Cemented versus Uncemented Hip Arthroplasty for Oncologic Bone Disease: A Multicenter Evaluation (Lazarides) Exploiting Epigenetic Vulnerabilities In Glioblastoma Stem Cells Through Reprogramming (Etame) Trends in Postoperative Nausea and Vomiting at Moffitt McKinley Outpatient Center (Yeoh) Investigating the effects of preoperative radiotherapy for impending fractures and long bone lesions (Lazarides)

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POPULATION SCIENCE POSTERS Listed alphabetically by last name Presenter Abdulla, Rania

Amorrortu, Rossybelle

Antoine , Kiana Arevalo, Mariana

Bollineni, Amruta

Brito, Samuel Brown, Nashira Cottrell-Daniels, Cherell

Denis, Justin Garcia, Melany

Haddan, Sofia

Lake, Paige

Llanos, Julia Mohammed, Turab

Morais Lyra Junior, Paulo Cilas Murphy, Anastasia Nepomuceno, Thales

Title (mentor) Promoting Colorectal Cancer and Hepatitis C Virus Screening among Diverse Patients Born 1945-1965: Intervention Satisfaction and Post-intervention Screening Intentions (Christy) Formative research to support development of digital tools to increase referral and enrollment to therapeutic clinical trials among Black/African American and Hispanic patients at an NCI Designated Comprehensive Cancer Center (Rollison) A feeding study examining the effects of diet-specific interventions on inflammatory markers (Carson) Scaling up the Patient Researcher Forum: Lessons learned from the expansion of a model for translational research engagement (Vadaparampil) Examining Participation in Electronic Patient-Reported Outcome (ePRO) Reporting as a Part of Supportive Care (Turner) Functional characterization of RECQL4 missense variants: A protein level-based approach (Monteiro) Identifying Differences in Cancer-related Beliefs and Affect by Sunburn Status (Kanetsky) Demographic, smoking, and health correlates of cannabis and tobacco co-use among adults with low SES in a smoking cessation RCT (D. Vidrine) Saliva Sample Collection in a Prostate Cancer Genetic Risk Pilot (PCGR) Study (Gwede) Multi-level intervention to increase minority cancer patient enrollment to cancer clinical trials: a study design decisionmaking framework and baseline characteristics from the ACTWONDER2S study (Rollison) Novel case-control analyses identifies high-risk subgroups in lung cancer screening: Post hoc analysis of the National Lung Cancer Screening Trial (NLST) (Schabath) Factors associated with patient-centered communication perceptions among Adolescent and Young Adult (AYA) cancer patients (Vadaparampil) Associations of the gut microbiome with breast tumor immunity in the Ghana Breast Health Study (Byrd) Marijuana use may be associated with reduced prevalence of prostate cancer: A cross-sectional study using the national survey on drug use and health database (J. Zhang) Integration of functional data to classify BRCA1/2 missense variants: an ENIGMA project (Monteiro) Bridging health disparities in the data-driven world of artificial intelligence: a narrative review (Green) The BRCA1-associated role of CDK9 in response to DNA damage is independent of its canonical role in transcription (Monteiro)

Poster # 16

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Owens, Heather Pitcher, Scott Ponce, Delilah

Stanley, Nathanael

Tapia-Kwan, Elliott

Whitmer, Ashley

Yang, Min-Jeong

Zamani, Shahrzad

Zhao, Yayi

HPV MISTICS Intervention Reporting: Utilization of the Implementation Research Logic Model (Vadaparampil) Associations of body composition with early onset colorectal cancer (Byrd) Developing a Comprehensive Training Curriculum for Community Health Educator led outreach and navigation strategies to increase referral and enrollment of Black/African American and Hispanic patients to cancer therapeutic clinical trials (Vadaparampil) A comparative demographic analysis of populations surrounding outreach locations and priority populations for the cancer center (Simmons) Patient perspectives on digital tools and CHE-led intervention components to reduce barriers to cancer clinical trials: A qualitative analysis from the ACT WONDER2S study (Vadaparampil) “A great step in treating cervical cancer”: Patient and Provider Perceptions about Cervical Cancer Therapeutic Vaccines (Vadaparampil) Perceived utility and acceptability of an mHealth mindfulnessbased intervention for smoking cessation among patients diagnosed with cancer: A mixed-methods approach (Vinci) Differences in disclosure, demographics, cancer diagnoses, and survival among Sexual and Gender Minority populations at the Moffitt Cancer Center (Schabath) Prevalence of factors serving as common cancer clinical trial eligibility criteria by race and ethnicity (Rollison)

139 145 146

170

171

185

195

197

200

QUANTITATIVE SCIENCE POSTERS Listed alphabetically by last name Presenter Bekker, Rebecca Carvajal, Daniel

Dao, Ken Phong Davis, Joshua Forero Pinto, Ana Froid, Matthew Gallaher, Jill Gonzalez, Glebys Havor, Phebe

Joseph, Jennifer Manjith, Meghna Marzban, Sadegh Masud, M A Namgoong, Won

Narvaez-Bandera, Isis Nguyen, Trieu Obermayer, Alyssa

Ojwang, Maureiq Rachakonda, Kartik Scott, Emmanuel Upadhyaya, Diya

Title (mentor) Spatially Fractionated Radiotherapy Potentiates Immune-Mediated Tumor Control (Pilon-Thomas) CLEAR-MATCH: CLinical Enrollment Assistant in Research Studies for Trial MATCHing using Large Language Models (Eschrich) Identifying Hallmark Cellular Stress Pathways in TET2 Mutated Patients using BEAT AML data (Shaw) BatchFLEX: Feature-Level Equalization of X-batch in heterogenous immunological data (Shaw) In silico modeling of cell-stroma physical interactions in a growing cell colony and ductal carcinoma in situ (Rejniak) An Agent-Based Model Predicts Optimal Combination Therapy to Mitigate the Janus Phenomena in AML (Basanta) Mathematical model driven adaptive therapy in advanced basal cell carcinoma (Anderson) A Feasibility Study on Ionizing Radiation Acoustic Imaging for Dose Mapping in FLASH Proton Beams (El Naqa) Personalized Radiotherapy Adaptation in HPV+ Oropharyngeal Squamous Cell Carcinoma using Mathematical Modeling of Tumor Dynamics and Circulating Tumor DNA (Brady-Nicholls) Unraveling molecular impacts of HPV16 variants in oropharyngeal cancer: a pilot study by re-analyzing TCGA RNA-seq data (M. Teng) Investigating Role of Mucins, Biofilm-Related Biomarkers, to Predict Response to Therapy in Colorectal Cancer (Karolak) Collagen-immune interactions lead to poor immune infiltration in late-stage head and neck squamous cell carcinomas (West) An integrated approach to understanding how skin hoemeostatis impacts Basal Cell Carcinoma treatment response (Anderson) Investigating macrophage–breast tumor cell interactions under ER inhibitors using mathematical models of 2D and 3D co-cultures (Rejniak) Multi-omic landscape of squamous cell lung cancer (Stewart) Transformer Graph Variational Autoencoder for De Novo Drug Design (Karolak) Analysis of clonal heterogeneity within paired primary and metastatic tumor samples of patients with solid tumors and implications for neoantigen-based personalized cancer vaccines (Shaw) A histological data-driven analysis of the hypoxic microenvironment of preclinical murine bladder tumors (Rejniak) Multi-omic analysis of lung adenocarcinoma reveals novel inflammatory and metabolic subtypes (Stewart) Adaptive Radiation Fractionation in Head and Neck Cancer through Modeling Tumor Volume Dynamics (Ahmed) Patient Reported Outcomes as Indicators of Treatment Progression (Brady-Nicholls)

Poster # 31 43

50 52 68 70 71 74 80

89 109 112 113 125

127 131 133

134 149 158 177

Weh, Malgorzata Xella, Agata Zitu, Md Muntasir

Adaptation to cancer treatment depends on cell’s ability to mutate (Basanta) Exploiting cancer plasticity through sequential combination therapy (Anderson) Development of Natural Language Processing (NLP) Models Using Real-World Moffitt Patient Data: A Study Design Framework and Illustrative Example Using Cancer Registry and Pathology Reports (Rollison)

184 190 202

TRANSLATIONAL SCIENCE POSTERS Listed alphabetically by last name Presenter Bazargan, Sarah Carvalho, Larissa

Estrella, Veronica Gullapalli, Keerthi

Kato, Ryoji

Law, Vincent

Naderinezhad, Samira Neelature Sriramareddy, Sathya

Obertopp, Nina Oluwatola, Oluwaseyi Pelle, Eleonora Phadke, Manali Poovathukaran Babu, Abida

Rossetti, Renata Tauro, Marilena Uriepero-Palma, Angimar Zheng, Hong

Title (mentor) Targeting Acidity in Bladder Cancer to Enhance Efficacy of Adoptive Cell Therapy (ACT) with Tumor Reactive T cells (Pilon-Thomas) Defining the anti-tumor activity and immune effects of the RASMULTI(ON) inhibitor RMC-7977 in preclinical models of NRASmutant melanoma (K. Smalley) Evaluation of Nanobodies against CAIX and CAXII for the Detection of Breast Cancer Metastasis (Morse) Alterations in tumor immune microenvironment and progressive immune exhaustion with advancing penile squamous cell carcinoma using multiplex immunofluorescence and image analysis (Chaoud) High RAS–RAF interaction as assessed via proximity ligation assay correlates with response to KRASG12C inhibitors in KRASG12C–positive non–small cell lung cancer (Haura) Intrathecal delivery of peptide-pulsed Type 1 conventional dendritic cell vaccine is highly efficacious for the treatment of breast cancerassociated leptomeningeal disease in preclinical models (Forsyth) MTRNR2L8 boosts mitochondria fitness and anti-apoptotic signaling in CD19 CAR-T (Locke) The development of uveal melanoma liver metastases is dependent upon a GDF15-driven reprogramming of the microenvironment (K. Smalley) Utilizing radiation to improve adoptive cell therapy with tumor infiltrating lymphocytes (Pilon Thomas) Transdermal buffer therapy reduces tumor burden and elicits OVAspecific responses in mice tumors (Pilon-Thomas) A novel hormone based anti-SSTR bispecific T-cell engager for the treatment of neuroendocrine tumors (Strosberg) The role of anti-PD-1+anti-LAG-3+anti-CTLA-4 triple combination in treatment of melanoma brain metastases (K. Smalley) Phase I study of ceritinib plus docetaxel in anaplastic lymphoma kinase (ALK)-negative, EGFR WT advanced non-small cell lung cancer (NSCLC) (Saltos) Stimulation of tumor infiltrating B-cells improves ex-vivo TIL expansion immunotherapy (Abate-Daga) Impairment of autophagic metabolic adaptation to reshape the destiny of triple negative breast cancer cells (Lynch) Targeting S100-A9 to Reverse the Immunosuppressive Tumor Microenvironment in Chronic Lymphocytic Leukemia (Pinilla-Ibarz) HDAC inhibitors directly modulate T cell gene expression and signaling and promote development of effector-exhausted T cells in murine tumors (Beg)

Poster # 30

44 63

76

90

99 123

128 66 135 141 144

147 155 172 178

201

2024 MOFFITT SCIENTIFIC SYMPOSIUM COMMITTEE Dr. Jong Park (Co-Chair) Dr. Evan Wuthrick (Co-Chair) Dr Yoga Balagurunathan Dr. Leidy Isenalumhe Dr. Richard Jacobson Dr. Zena Jameel Dr. Matthew Mills Dr. John Mullinax Dr. Thales Nepomuceno Dr. Gage Redler Dr. Katarzyna Rejniak Dr. Michael Shafique Dr. Moazzam Shahzad Dr. Vani Simmons Dr. Lixin Wan Dr. Liang Wang

EVENT COORDINATORS Jill Fraley Angela Reagan Sarah Riordan