2023 Moffitt Scientific Symposium Guidebook

PROGRAM AGENDA Day 1 – Tuesday, May 16th, 2023 SRB Ted Couch Auditorium 4:00-5:00 PM

W. Jackson Pledger Researcher of the Year lecture: Anna Giuliano, Ph.D. “Eliminating HPV-related Cancers – Research to Impact Public Health”

5:00-6:00 PM

Reception in SRB Murphy

Day 2 – Wednesday, May 17th, 2023 USF Marshall Student Center 8:00-9:00 AM

Registration, Breakfast & Poster Viewing in the Ballroom

9:00-9:10 AM

Welcome, Ken Wright, PhD, ACD Research Education and Training (Oval Theater)

9:10-9:35 AM

Featured Poster Presentations - Session I (Oval Theater) Moderator: Dr. Katarzyna Rejniak Dr. Luis Aguirre “Validation of the Molecular International Prognostic Scoring System (IPSS-M) Risk Stratification Model for Myelodysplastic Syndromes” Dr. Cherell Cottrell-Daniels “Associations of Cancer Treatment Status on Smoking Cessation Among Survivors of CIN or Cervical Cancer” Dr. Ou Deng “PARP16 modulates MYC expression and susceptibility of Ewing’s Sarcoma cells to PARP1 inhibition” Dr. Ammoren Dohm “Upfront Osimertinib Alone Versus Osimertinib and Radiotherapy for the Treatment of EGFR-positive NSCLC Brain Metastases: A Multi-institutional Series” Dr. Thomas Dombrowski “Tumor-immune ecosystem dynamics exploration via a high-resolution agent-based model” Dr. Saurabh Garg “The correlation of oncodriver expression with tumor infiltrating lymphocytes in triple negative breast cancer (TNBC)” Dr. Rebecca Hesterberg “Aging dampens lymphoma-provoked phenotypic and epigenomic changes to the adaptive immune system” Dr. Filip Ionescu “Fludarabine Exposure Impact on Safety and Efficacy of Idecabtagene Vicleucel in Relapsed/Refractory Multiple Myeloma”

9:35-10:00 AM

Featured Poster Presentations - Session II (Oval Theater) Moderator: Dr. Gage Redler Dr. Daria Miroshnychenko “Stroma-induced cancer cell proliferation accelerates tumor recovery between chemotherapy cycles” Mostafa Nasr “PRDM16: A key switch enabling long term skeletal dormancy and survival in prostate cancer” Dr. Eleonora Pelle “A novel hormone-based anti-SSTR T-cell engager for the treatment of neuroendocrine tumors”

Dr. Jennifer Perone “Evaluation of an Intraoperative Critical Event (ICE) Team at a Major Cancer Center” Dr. Marilena Tauro “Novel autophagy inhibitory strategies to treat multiple myeloma” Malgorzata Tyczynska-Weh “Modeling selection for evolvability in the evolution of cancer therapy resistance” Dr. Tomas Zelenka “Bcl11b is a bimodal switch between stem-like and effector Trm cells in infection and tumor”

10:00-11:30 AM

Poster Session #1 (Ballroom) Odd numbered Posters

11:30- 12:30 PM

Lunch (Ballroom)

12:00-1:30 PM

Poster Session #2 (Ballroom) Even Numbered Posters

1:45-2:35 PM

Oral Presentations – Session I (Oval Theater) Moderator: Dr. Russell Palm Dr. Facundo Davaro “Impact of Surgical Margin & Extent of Lymphadenectomy on Oncologic Outcomes in Plasmacytoid Urothelial Carcinoma” Dr. Chandler Gatenbee “VALIS: Virtual Alignment of pathoLogy Image Series” Vincent Law “Development of Intrathecal Drug Delivery Platform to Cure Breast Cancer Leptomeningeal Disease by Dendritic Cell Immunotherapy in Preclinical Model” Dr. Shelly Li “Effects of Social Isolation on Symptoms of Depression and Anxiety among Young Adult Cancer Survivors: The Mediating Role of Social Support” Dr. Karnav Modi “Frailty and high-risk immuno-nutritional score are associated with inferior outcomes in patients with relapsed and refractory multiple myeloma treated with chimeric antigen receptor T-cells”

2:35-3:25 PM

Oral Presentations – Session II (Oval Theater) Moderator: Dr. Evan Wuthrick Dr. Thales Nepomuceno “A comprehensive analysis of BRCA1 frameshift variants leading to extended incorrect protein termini” Alyssa Obermayer “Transcriptome analysis and machine learning identify therapeutic strategies for high-risk pediatric AML patients of the KMT2A-fusion subgroup” Devesh Raizada “Age-induced chronic accumulation of cortisol drives therapy resistance in lung cancer” Dr. Fnu Sathyanarayana Neelature “To define how the uvel melanoma-liver environment crosstalk shapes metastasis growth and therapeutic response” Dr. Leticia Tordesillas “Biodistribution of zoledronate and effects on gamma delta PSCA-CAR T cells in a model of bone metastatic prostate cancer”

3:25-3:40 PM

Awards and Closing Remarks, Dr. Jong Park & Dr. Evan Wuthrick (Oval Theater)

TRANSPORTATION A Moffitt shuttle bus will be running a continuous route between Moffitt and the USF Marshall Center on Wednesday, May 17th from 7:30AM-4:00PM. You may also choose to walk or drive your personal vehicle if you have an appropriate USF parking permit.

Please see map below for exact shuttle stop locations Shuttle stop =

POSTER MAP USF Marshall Student Center Ballroom

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MOFFITT SCIENTIFIC SYMPOSIUM FREQUENTLY ASKED QUESTIONS (FAQ) 1. Where is the Symposium located?

Tuesday, May 16th, 2023 - the W. Jackson Pledger Researcher of the Year lecture will take place in the Stabile Research Building (SRB) Ted Couch Auditorium followed by a reception in the SRB Murphy conference room.

Wednesday, May 17th, 2023 - all activities will be at the USF Marshall Student Center.

2. Can I attend if I did not RSVP? Yes, we prefer that everyone RSVPs, but you can still attend if you forgot.

Link to RSVP: https://www.surveymonkey.com/r/B9R3ZDW 3. How can I get to the Marshall Center? Is there parking?

Reserved parking has been set aside for featured posters, oral presenters, committee members and speakers only. General attendees should walk to the Marshall Center or take the Moffitt shuttle which will be continuously running between Moffitt and the Marshall Center. Please review the transportation page in this guide for shuttle locations and times.

4. How do I know what poster session I can find certain presenters?

This guidebook shows the poster number for every presenter. The poster sessions are divided up by odd numbered posters (poster session #1) and even numbered posters (poster session #2).

5. Is there Wi-Fi available at the Symposium?

Wireless access is provided to guests of USF. Please follow these directions: 1.)

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Open your list of wireless connections on your device and select “USF-Guest” Once you are connected, open your web browser and attempt to navigate to a website. You will automatically be redirected to the Guest Registration page On this page, select your preferred method of contact. Either “call me on my phone” or “send me a text message” You will receive a temporary access code within 5 minutes. Select the option “I have my access code”. You will need to agree to the acceptable use policy to continue

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Enter your mobile phone number and the registration code you received and hit “submit” You are now connected to the USF-Guest network. The registration will last for 24 hours and is valid for 1 device.

6. What will the food options be?

May 16th Reception: selection of hors d’oeuvres including vegetarian, vegan, and gluten free options with beer/wine bar May 17th Breakfast: assorted muffins, scones, danish, fresh fruit, coffee, juice, and tea May 17th Lunch: assorted sandwiches and wraps including vegan, vegetarian, and gluten free options, garden salad, potato salad, assorted desserts, and lemonade Water and coffee will be available all day in the Ballroom on May 17th 7. How do I vote for the People’s Choice award?

Everyone who attended the Symposium on May 17th (and signed in at the registration desk) will receive an electronic ballot via email on May 18th. Deadline to vote is Friday, May 19th by 5PM. The winner will be announced in Signals the week of May 22nd. Featured Poster presenters and Oral presenters are not eligible for the People’s Choice award

FEATURED POSTERS Presenter Luis Aguirre

Cherell Cottrell-Daniels

Ou Deng Ammoren Dohm

Thomas Dombrowski Saurabh Garg

Rebecca Hesterberg

Filip Ionescu

Daria Miroshnychenko

Mostafa Nasr Eleonora Pelle Jennifer Perone Marilena Tauro Malgorzata Tyczynska-Weh Tomas Zelenka

Title (mentor) Validation of the Molecular International Prognostic Scoring System (IPSS-M) Risk Stratification Model for Myelodysplastic Syndromes (Komrokji) Associations of Cancer Treatment Status on Smoking Cessation Among Survivors of CIN or Cervical Cancer (Vidrine) PARP16 modulates MYC expression and susceptibility of Ewing’s Sarcoma cells to PARP1 inhibition (Rix) Upfront Osimertinib Alone Versus Osimertinib and Radiotherapy for the Treatment of EGFR-positive NSCLC Brain Metastases: A Multi-institutional Series (Ahmed) Tumor-immune ecosystem dynamics exploration via a high-resolution agent-based model (Enderling) The correlation of oncodriver expression with tumor infiltrating lymphocytes in triple negative breast cancer (TNBC) (Czerniecki) Aging dampens lymphoma-provoked phenotypic and epigenomic changes to the adaptive immune system (Cleveland) Fludarabine Exposure Impact on Safety and Efficacy of Idecabtagene Vicleucel in Relapsed/Refractory Multiple Myeloma (Hansen) Stroma-induced cancer cell proliferation accelerates tumor recovery between chemotherapy cycles (Marusyk) PRDM16: A key switch enabling long term skeletal dormancy and survival in prostate cancer (Lynch) A novel hormone-based anti-SSTR T-cell engager for the treatment of neuroendocrine tumors (Strosberg) Evaluation of an Intraoperative Critical Event (ICE) Team at a Major Cancer Center (Gonzalez) Novel autophagy inhibitory strategies to treat multiple myeloma. (Lynch) Modeling selection for evolvability in the evolution of cancer therapy resistance (Basanta) Bcl11b is a bimodal switch between stem-like and effector Trm cells in infection and tumor (Avram)

Poster # 001

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BASIC SCIENCE POSTERS Listed alphabetically by last name Presenter Suehelay Acevedo Acevedo Santanu Adhikary Hasan Alhaaddad

Anika Ali Parisa Amirifar

Rafael Bravo Chase Burton

Daiana Celias

Manon Chadourne Neelkamal Chaudhary

Janine DeBlasi Avani Deshpande Michael Emmons Jeremy Frieling

Wael Gamal Miguel Gomez Fontela

Maria Gonzalez- Rodriguez

Michael Grant Crystal Griffith

Title (mentor) Determining the role of ΔNp63 in lung adenocarcinoma progression (Flores) Delta Np63 drives metabolic reprogramming in breast cancer via long noncoding RNAs (Flores) Meningeal stroma–tumor cell crosstalk promotes tumor growth and drug resistance in melanoma leptomeningeal metastasis (Smalley) Deciphering the link between translational dynamics and HLA-I antigen presentation (Jaeger) Functional and biological heterogeneity of Oncogenic KRAS G12 Alleles in Non-Small Cell Lung Cancer (NSCLC) (Kissil) Using MRI scans to predict tumor margin propagation in GBM under immunotherapy (Anderson) L-fucose enhances anti-tumor immunity through modulation of monocyte-derived dendritic cell signaling (Lau) Investigating the mechanisms involved in HMGB1dependent DNA uptake and STING activation in dendritic cells (Ruffell) Evidence of glycosylated RNA in melanoma and melanocytes cell lines (Karreth) An Imaging flow cytometry-based analysis of small extracellular vesicles in platelet-poor plasma samples from healthy donors and cancer patients (Rodriguez) Distinct NRF2 signaling thresholds mediate lung tumor initiation and progression (DeNicola) TROLL-9 as a novel tumor suppressor in breast cancer (Flores) Epigenetic regulation of brain metastasis formation in stress-resistant melanomas (Smalley) Elucidating reciprocal interactions between bone marrow stromal cells and γδ CAR T cells in the context of bone metastatic prostate cancer (Lynch) Metabolic Dysregulation in CLL T cells (Pinilla-Ibarz) Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) immune checkpoint modulates CAR-T cell effector function (Abate-Daga) Combined inhibition of BET proteins and FAK1 as a novel therapeutic strategy for Neurofibromatosis Type 2-related Schwannomas (Kissil) The Role of ITCH in CD8+ T-Cell Activity and The Melanoma Tumor Microenvironment (Wan) CDH3 functions as a melanoma suppressor and its expression is affected by Long Non-coding RNA CDH3-AS1 (Karreth)

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Kay Hänggi

Qianqian Hu

Briley Humphrey

Mohammad Ibrahim

Neel Jasani Rachel Jimenez

Hossein Kashfi Anna Koktysh Felicia Lazure Daniel Lester

Jie Li Yi Liao

Jay Lockhart

Mariam Lotfy Khaled

Ashley Lui

J Mandula

Renata Marques Rossetti Michael Martinez Elena Martinez Planes

Angelie Matar

Necroptosis promotes tumor growth through IL1-alpha release and recruitment of immunosuppressive myeloid cells (Ruffell) Cancer-associated fibroblasts confer ALK TKI resistance via MET and integrin signaling in ALK-rearranged lung cancer (Rix) Synthesis of Inhibitors and PROTACs as Chemical Probes for the Biological Evaluation of JAK2 Inhibition and Degradation (Lawrence) Sotorasib indirectly promotes antitumor T cell immunity and enhances immunotherapy response through enrichment of TNFα and IFNγ signals in G12C-KRAS mutant cancer cells. (Beg) BRAF- mediated PHGDH induction establishes a metabolic vulnerability in melanoma (Karreth) The Unfolded Protein Response as a Novel Therapeutic Target in Leptomeningeal Disease and Brain Metastases (Rodriguez) Quinolinic acid phosphoribosyl transferase (QPRT) is an essential liability of non-small cell lung cancer (Gomes) IND enabling studies for rare skin cancer targeted alpha particle therapy (Morse) The effect of CD320-mediated vitamin B12 uptake in breast cancer transformation (Gomes) HLA-DRB1 fucosylation regulates CD4+ T cell mediated anti-melanoma immunity and enhances immunotherapy efficacy (Lau) Evaluate targeting ENPP1 in combination with PARPi to boost anti-tumor immunity in TNBC (Ruffell) Integrative and differential network analysis unravels lorlatinib polypharmacology in ROS1-positive NSCLC by cotargeting PYK2 (Rix) Guided integrated spatial multi-omics in archival tissue of lung adenocarcinoma models using machine learning (Flores) Branched-chain keto acids exert an immune-suppressive and neurodegenerative microenvironment in CNS leptomeningeal lymphoma (Smalley) RNA Based Therapeutics to target the p53 pathway in cancer: TAp63-Regulated Oncogenic LncRNAs (TROLLs) as novel therapeutic targets in cancer (Flores) Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages (Rodriguez) CD40L stimulates melanoma infiltrating B cells and enhances ex vivo TIL expansion (Abate-Daga) Elucidating the MAFG interactome in melanoma (Karreth) IL-2-inducible T-cell kinase (ITK) is required for CD28 Y218 phosphorylation, an essential residue for IL-2 secretion and antitumor effect of CAR-T cells. (Abate-Daga) Optimization of ACK1 Inhibitors Utilizing a Pyrrolopyrimidine Scaffold (Lawrence)

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Jenet Matlack Nicol Mecozzi Marco Napoli Niveditha Nerlakanti Alexis Onimus Omotayo Osunmakinde Thiyagu Pandurangan

Taylor Peak Manali Phadke

Marine Potez

Rafael Renatino Canevarolo Jyoti Srivastava Joanne Tejero

Laura Torrente Fernandez Benito Traversa

Preethi Varughese

Torus Washington Andrew Weeden Gabriela Wright Shengyan Xiang Xiaonan Xu Vipin Yadav

Molecular mechanisms governing substrate specificity in mammalian deglycation pathways (Binning) Investigating the metastatic potential of circPMS1 in melanoma (Karreth) Metabolic reprogramming drugs as a novel therapeutic strategy to target the p53 pathway in cancer (Flores) Oncogenic role of Neuropilin-1 in osteosarcoma growth and metastasis (Lynch) HMGB1 release predicts chemotherapy combinatorial efficacy with TIM-3 blockade (Ruffell) Investigating cholesterol transfer between macrophages and prostate cancer cells (Ruffell) Discovery and optimization of novel imidazo[1,2-b] pyridazine analogues as potent CDK12 inhibitors for the treatment of TNBC (Monastyrskyi) Alterations in RNASET2 Impact the Pathogenesis of Clear Cell Renal Cell Carcinoma (Manley) The anti-PD1+anti-LAG3 and anti-CTLA4+anti-PD1 combinations have non-overlapping mechanisms of action in melanoma cranial and extra cranial metastases.

(Smalley) Using hypoxia to improve Tumor Infiltrating Lymphocytes therapy in different subtypes of renal cell carcinoma (Pilon-Thomas) The multiomic landscape of the evolution of the Warburg effect identifies drivers of breast cancer (Silva) Role of Acetyl Zingerone and Its Derivatives in Inhibiting UV-Induced DNA Damage (Premi) Methylmalonic acid accumulation suppresses CD8+ T cell activation and contributes to age-induced immunosuppression (Gomes) Aberrant activation of NRF2 in NSCLC confers sensitivity to copper starvation (DeNicola) Chronic upregulation of glucocorticoid hormones triggers chromatin remodeling in NSCLC through dynamic regulation of Histone H3 chaperones (Gomes) Development of the Cu-64-MTI-201 Companion PET Imaging Tracer for Ac-225-MTI-201 Targeted AlphaParticle Therapy (Morse) Bowls aren’t just for cereal: Silica Nanobowl drug delivery for effective lung cancer treatment (Morse) Engineering new mouse models to study antigen presentation in vivo (Jaeger) Loss of CX3CL1 expression mediates immune evasion in STK11 mutated lung adenocarcinomas (Cress) Human CMG Helicase ATPase Domains Stabilize Replisome Structure to Prevent DNA Damage (Alexandrow) Understand the metastasis of uveal melanoma in vivo via novel mouse models (Karreth) NRAS-mutant melanoma sensitized to MEKi in response to nitrosylation inhibition (Premi)

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Maya Yasukawa Sang Jun Yoon

HIRA is an epigenetic regulator that underlies chemotherapy resistance in ovarian cancer (Gomes) Mechanism and role of non-canonical cystathionine synthesis in cancer (DeNicola)

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CLINICAL SCIENCE POSTERS Listed alphabetically by last name Presenter Othman Akhtar

Kate Beekman Nicholas Champion Ruben Cruz-Chamorro

Claire Dalby

Danielle Depalo

Justin Drake

Dereen Duhoki

Kelly Elleson Katherine Englander Julia Gallagher Vivian Irizarry Gatell

Richard Jacobson

Akriti Jain

Grace Johnson

Vaseem Khatri

Tiffani Mathew

Title (mentor) Safety and Efficacy of Anti-BCMA CAR-T Cell Therapy in Older Adults with Multiple Myeloma: a Systematic Review and Meta-analysis (Freeman) Radar-Guided Localization for Melanoma Metastasectomy (Zager) Surgeon and Radiologist Evaluation of Electromagnetic Chip Localization for Breast Conservation Surgery (Lee) Outcomes of Patients with Radioresistant Brain Metastases treated with Fractionated Stereotactic Radiotherapy alone or Surgery followed by Fractionated Stereotactic Radiotherapy (Yu) Effects of Preoperative Diabetes Mellitus on Postoperative Outcomes after Robotic-Assisted Video-Thoracoscopic Pulmonary Lobectomy (Toloza) Intralesional therapy, limb infusion/perfusion, and immune checkpoint inhibitors as first-line therapy in surgically unresectable melanoma in-transit metastases (Zager) Progressive Improvements in Postoperative Outcomes with Over 500 Robotic Transthoracic Esophagectomies at a Single Institution (Sinnamon) Usual and Underrecognized Histomorphology of Pancreatic Ductal Adenocarcinomas Associated with Preoperative Neoadjuvant Management (Jiang) Features of Breast Cancer Nodal Metastasis (Lee) Factors Influencing Lymph Node Positivity in HER2.neu+ Breast Cancer Patients (Lee) Factors Associated with Node-Positive Disease in Estrogen Receptor-Positive (ER+) Breast Cancer Patients (Lee) Clinical Outcomes of Adults Undergoing Allogeneic Stem Cell Transplant for Secondary Acute Lymphoblastic Leukemia (Faramand) Safety and efficacy of diagnostic laparoscopy in patients with colon peritoneal metastases: A contemporary analysis (Dineen) Post-allogeneic Stem Cell Transplant Outcomes in Patients treated with Hypomethylating Agent plus Venetoclax Compared to CPX-351 (Sweet) Remissions endure despite B-cell recovery following antiCD19 CAR T therapy for DLBCL in a single-center study (Jain) An Assessment of Toxicity with Pelvic Radiotherapy following Prostate Artery Embolization: a single-institution retrospective review (Parikh) Adenosquamous Carcinoma (ASC) of the Head and Neck (HN): A Comparative and Molecular Study of HPV-

Poster # 140

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Christine Mau

Virginia Mazack James McDonald

Ruoyu Miao

Turab Mohammed

Razan Mohty

Prithvi Murthy

Justyn Nakashima Nour Nasser

Nayeon Oh

Hilal Ozakinci

Robin Park

Maulik Patel

Matthew Perez

Yanet Prieto Carratala John Puskas

Associated and HPV-Independent Tumors (HernandezPrera) Efficacy of Kyphoplasty alone versus Kyphoplasty and Radiofrequency Ablation on Osteoblastic Lesions in Breast Cancer patients: A Single-center 10-year experience (Tran) Detecting Uncommonly Long FLT3 ITD Mutations in AML (Qin) Hospital surgical volume is poorly correlated with delivery of multimodal treatment for localized pancreatic cancer. A national retrospective cohort study. (Powers) Biomarker Analysis to Predict Response in Patients with Metastatic Mismatch Repair Proficient Colorectal Cancer Treated with Regorafenib and Nivolumab (Kim) Incidence and risk factors associated with bleeding following anti-B cell maturation antigen chimeric antigen receptor T-cell therapy in patients with relapsed/refractory multiple myeloma (Hansen) Hematopoietic Recovery after Anti-B Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor T Cell Therapy (CAR T), Idecabtagene Vicleucel (Ide-cel), for Relapsed/Refractory Multiple Myeloma (RRMM) (Hansen) Survival Benefits of Adjuvant Chemotherapy for Positive Soft Tissue Surgical Margins Following Radical Cystectomy in Bladder Cancer with Extravesical Extension (Li) Outcomes of Patients with Transformed Diffuse Large BCell Lymphoma (DLBCL) (Kim) Feasibility of Novel Low Dose Radiation Treatment of Polymetastatic disease in Stage IV NSCLC Patients Receiving Systemic Immunotherapy to Improve Response (Redler) An Analysis of Patients Treated with Stereotactic Body Radiotherapy for Metastatic Urinary Tract Tumors to Identify Predictors of Response (Grass) Molecular subtyping of donated small cell lung carcinoma samples with a clinical targeted expression panel (RNA step) (Boyle) Association of Neutrophil-Lymphocyte Ratio (NLR) with Clinical Outcomes in Patients (pts) with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) Treated with Combination of Cetuximab and Nivolumab (C+N) (Chung) MRI for prediction of pCR in patients with HER2+ Breast Cancer Treated with Neoadjuvant Immunotherapy Followed by Neoadjuvant Chemotherapy (Weinfurtner) Management of primary anorectal mucosal melanoma in the era of modern systemic immunotherapy and targeted therapy (Zager) Idylla MSI assay for fast patient screening to identify candidates for immunotherapy (Bossler) Clinical Validation of a Comprehensive RNA-based Solid Tumor Fusion Extended (SafireX) Panel (Boyle)

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Ryan Putney Elena Ryzhova Lamees Saeed Danial Shaikh

Marian Smallin Wenxin Song Sean Stokes Caleb Streitmatter

Ram Thapa Amber Valeri

Ricardo Villanueva

Yan Wang

Shawna Watson

Junmin Whiting

Keith Wirth Jodie Wong James Yu

Jennifer Zhou

Methylation-Driven Gene Expression Differences in African American and European American Men (Yamoah) Validation of Idylla™ EGFR Assay for rapid detection of EGFR mutations in patients’ FFPE tissues (Bossler) HER2 Interpretation Reproducibility in HER2-low Breast Cancer (Rosa) Differences in gender and overall survival for temperaturesensitive TP53 mutations in a gastroesophageal cancer (Mok) The Chromosome 19 MicroRNA Cluster Suppresses T Cell Immunity in Cancer Tissues (Brohl) Group Piano Training on Quality of Life and Cognition in Patients with Cancer (Mallory) Practice Patterns and Outcomes of Acute Care Surgery in Cancer Patients (Dineen) A pilot randomized controlled trial comparing preanesthesia evaluation via telemedicine versus in-person for surgical patients at H. Lee Moffitt Cancer Center (Aldawoodi) Statistical Analysis Tool for Oncore-Generated Adverse Event (AE) Data (Chen) Hydrocephalus in Leptomeningeal Disease: Ommaya Reservoir-Shunt for Intrathecal Chemotherapy Administration (Tran) High metabolic tumor volume and its association with higher toxicity and decreased efficacy of BCMA CAR-T cell therapy in multiple myeloma (Freeman) How many were missed: originally undiagnosed microsatellite unstable gastrointestinal carcinomas?

(Jiang) Increased mechanical implant failures with combined Type III pelvic resections for reconstruction of periacetabular pelvic tumor resections using patient-specific implants (Joyce) Discovery of Predictive Gene Signatures for Combining Chemotherapy with Avastin in Metastatic Colorectal Cancer (Chen) Tumor burden and liver specific survival after resection +/ablation of multifocal colorectal liver metastasis (Denbo) Targeted cell-free DNA methylation signature in metastatic castration-resistant prostate cancer (Wang) Biomarker analysis from a phase I/Ib study of regorafenib and nivolumab (rego/nivo) in microsatellite stable (MSS) colorectal cancer (CRC) (Kim) Treatment of Stage III Melanoma in the Post MSLT-II era: A literature review (Wuthrick)

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POPULATION SCIENCE POSTERS Listed alphabetically by last name Presenter Hannah Alex

Rossybelle Amorrotu Laura Casas

Paulo Cilas Morais Lyra Junior Diana Diaz

Cassandra Hathaway

Heather Huelster

Khushali Jhaveri Charles Lacson

Paige Lake

Ursula Martinez Pradeda

Samantha Montoya Gazelle Rouhani

Alon Rozental

Bethany Shorey Fennell Nathanael Stanley Yijun Tian

Title (mentor) Disparities in financial and psychological health outcomes amongst informal cancer caregivers during the COVID-19 pandemic (Byrne) Approaches to estimate real-world disease progression in lung cancer (Rollison) Hispanic/Latinx individuals’ attributions for abstinence and smoking: A content analysis of open-ended responses from a randomized cessation trial (Simmons) Integration of functional data to classify BRCA2 missense variants: an ENIGMA project (Monteiro) Bright IDEAS-Young Adults: Problem-Solving Skills Training to Reduce Distress among Young Adults with Cancer (Donovan) The Association of Kidney Function Biomarkers with Ovarian Cancer Risk and the Mediating Effects of Inflammation (Tworoger) Cost-effectiveness of Initial Management of High-grade T1 Bladder Cancer with Intravesical BCG vs Immediate Radical Cystectomy (Gilbert) 20-year Incidence Trends of Anal Squamous Cell Carcinoma (Kim) Predictors of correct recall of MC1R genetic risk among Hispanic individuals participating in a skin cancer precision prevention trial (Kanetsky) Family history and quality of life (QOL)-related factors associated with Adolescent and Young Adult (AYA) cancer patient requests for fertility consultations (Vadaparampil) Feasibility and Acceptability of a Targeted Self-Help Intervention to Increase Motivation to Quit Smoking among Oncologic Patients (Simmons) REAL World Implementation of Colorectal Cancer Screening (Gwede) Neighborhood Socioeconomic Disadvantage and Survival Outcomes Among Patients with Colorectal Cancer: Results from the ColoCare Study (Siegel) Feasibility of chimeric antigen receptor T-cell therapy in very old patients with relapsed/refractory diffuse large Bcell lymphoma: a single center analysis (Extermann) Perceptions of the proposed FDA graphic cigarette warnings among daily and nondaily smokers (Vidrine) Simultaneous Visualization of Spatial and Temporal Trends of Cancer Incidence (Vadaparampil) Combined CRISPRi and Proteomics Screening Reveal a Cohesin-CTCF-bound Allele Contributing to Increased Expression of RUVBL1 and Prostate Cancer Progression (Wang)

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Min-Jeong Yang

Shahrzad Zamani

Qualitative Evaluation of the Implementation and Future Sustainability of an E-referral System for Smoking Cessation at Moffitt Cancer Center: Lessons Learned (Simmons) Understanding the Disparities and Cancer Care Challenges Among Sexual and Gender Minority Patients (Schabath)

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QUANTITATIVE SCIENCE POSTERS Listed alphabetically by last name Presenter Shatha Abudalou Richard Beck Rebecca Bekker Thanh Duong Matthew Froid

Kit Gallagher Jill Gallaher

Daniel Glazar

Anjun (Angela) Hu Alex Johnson Tuan Dung Le Xiang Liu Gabrielle Nobles Maureiq Ojwang

Kayode Olumoyin

Stefano Pasetto

Sandhya Prabhakaran Mark Robertson-Tessi

Title (mentor) Deep Neural Network Architecture to detect Prostate Anatomy (Balagurunathan) Charting the fitness landscape of genomic copy number alterations (Andor) Black Holes in TIME: the Effect of GRID Radiation on the Tumor-Immune Micro-environment (Enderling) Cancer Comprehend Annotation – a pipeline for cancer phenotype and bioinformation extraction (Thieu) A Hybrid Machine Learning and Agent-Based Modeling Approach Illuminates Physical and Genetic Factors Contributing to Resistance in the AML Bone Marrow Niche (Basanta) Learning to Adapt - Deep Reinforcement Learning in Treatment-Resistant Prostate Cancer (Anderson) Predicting progression in metastatic castrate-sensitive prostate cancer by coupling PSA and testosterone dynamics to a mechanistic mathematical model (Anderson) A sample size analysis of a joint model of longitudinal tumor volume and progression-free survival in an in silico glioma clinical trial (Enderling) Modeling of macrophages – breast tumor interactions under ER inhibitors in 3D Microenvironments (Rejniak) Comparing Prostate Specific Antigen Dynamics Between Black Patients and White Patients (Brady Nicholls) Leveraging deep active-transfer learning to identify mobility functioning information in clinical text (Thieu) An epigenomic fingerprint of human cancers by systematically modeling super enhancer divergence (Teng) Developing a Single-Cell RNA-seq Reference Database for Primary and Metastatic Brain Cancer (Shaw) Using digitized histology images to assess the hindering effects of hypoxia on T cell infiltration in orthotopic bladder tumors in mice (Rejniak) A Machine Learning Predictor of the Expansion of Tumor Infiltrating Lymphocytes in Patients’ Bladder Tumors (Rejniak) Calibrating tumor growth and invasion parameters with spectral-spatial analysis of cancer biopsy tissues (Enderling) Agent-based model to study autocrine signaling effects in NSCLC following an active immune response (Anderson) The evolution of T-cell receptors in the context of viruses, cancer, and self-antigens (Anderson)

Poster # 071 186 128 189 168

059 025

158

056 068 018 125 085 126

047

111

110 135

Kirill Sabitov

Arpan Sahoo

Alex Soupir

Praneeth Sudalagunta Talha Syed

Zachary Thompson

Thomas Veith Zhouping Wei Joseph Weygand

Mohammad Zahid

Exploring the Spatial Architecture of the Tumor-Immune Microenvironment in Papillary Renal Cell Carcinoma (Fridley) Intrinsic disorder of blood-sourced TRB V-CDR3-J sequences correlates with a greater survival probability for uveal melanoma (Blanck) Spatial context of spatial molecular imaging aids in identification of differences between immunotherapy responders and non-responders in clear cell renal cell carcinoma (Fridley) A Novel Gene Regulatory Network Model Identifies Novel Therapeutic Targets in MM (Silva) Comparing the Capacity of 3 Mathematical Models to Forecast Tumor Volume Dynamics and Predict Individual Head and Neck Cancer Patient Responses to Radiotherapy.

(Enderling) Drepmel—A Multi-Omics Melanoma Drug Repurposing Resource for Prioritizing Drug Combinations and Understanding Tumor Microenvironment (Chen) Investigating the effects of frequency and densitydependent selection on cancer cells (Andor) Deep Neural Network Architecture to detect Prostate Anatomy (Balagurunathan) Accurate, repeatable, and geometrically precise diffusion imaging on a 0.35 T MRI- guided linear accelerator (Redler) Proliferation Saturation Index to Simulate Adaptive Radiation Fractionation in HPV-Associated Oropharyngeal Cancer (Enderling)

080

112

182

106 087

037

172 061 081

175

TRANSLATIONAL SCIENCE POSTERS Listed alphabetically by last name Presenter David Adams

Aileen Alontaga

Sarah Bazargan

Matthew Beatty

Liz Bridenstine

John Michael Bryant

Andrew Chang

Erika Eksioglu

Veronica Estrella

Curtis Gravenmier

Imene Hamaidi Denis Imbody

Ryoji Kato Shrikar Modukuri Nina Obertopp Ibrahim Oraiqat

Title (mentor) Patient Stratification for Wilms Tumor Using Physical and Chemical Properties of the Adaptive Immune Receptors IGL and TRG (Blanck) Comprehensive Tumor Profiling Reveals High Concordance of Gene Amplification with RNA Expression (Boyle) Modulating the Immune Microenvironment in Bladder Cancer to Enhance Efficacy of Adoptive Cell Therapy (ACT) (Pilon-Thomas) Expansion and identification of neoantigen reactive tumor infiltrating lymphocytes (TIL) from metastatic colorectal cancer (CRC) (Pilon-Thomas) Mutations in CTNNB1 can regulate resistance in EGFR Targeted Therapies for Non-Small Cell Lung Cancer (Haura) A novel multi-task (parallel) hybrid deep neural network predicts tumor progression during MRgRT compared to traditional delta radiomics (Rosenberg) Proteogenomic, epigenetic and clinical implications of recurrent aberrant splice variants in clear cell renal cell carcinoma (Manley) Improvement of hematopoiesis in low risk MDS with the Alk5 inhibitor TP-6379 improves hematopoiesis of primary low risk MDS and S100A9Tg mice (Wright) Characterization of humanized nanobodies that bind to CAIX and CAXII for use in the detection of breast cancer metastasis (Morse) B-Lymphoblastic Leukemia Subpopulation Dynamics Predict BCR::ABL1 and Philadelphia-Like Status, PostInduction Minimal Residual Disease, and 3-Year Relapse (Zhang) Sirt2 regulates the proximal T cell receptor signaling (Kim) Wildtype RAS Activity and PI3K Signaling as New Vulnerabilities in Cells with Acquired Resistance to Sotorasib (Haura) RAS:RAF proximity ligation assay may predict response to KRASG12C inhibitors in NSCLC (Haura) The CDK12/13 inhibitor SR-4835 prevents acquired resistance to the KRASG12C inhibitor adagrasib (Haura) Radiation enhances ex vivo expansion of tumorinfiltrating lymphocytes (TIL) (Pilon-Thomas) Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment (El Naqa)

Poster # 138

093

051

173

118

124

038

072

122

153

200 077

169 103 083 088

Garima Pandey

Kyle Rose

Hitendra Solanki

Joanna Song

Yaakov Stern Angimar Uriepero Palma Hong Zheng

Zhong Zheng

SHP2 Inhibition Suppresses RAS-ERK Signaling, the Development of JAK2 Inhibitor Persistence, and Disease Progression in Pre-Clinical Models of Myeloproliferative Neoplasms (Reuther) Cell-free urinary tumor DNA to detect minimal residual disease prior to repeat-transurethral resection of bladder tumor in non-muscle invasive bladder cancer: a prospective study (Li) SHP2i combination with Sotorasib effectively target KRASG12C tumors developing secondary resistance to Sotorasib via KRASG12C amplification (Haura) Hepatocellular carcinoma adaptive immune receptor profiling and association of electrostatic complementarity between CDR3 and hepatitis C viral epitopes with increased survival probabilities (Blanck) Targeting CDK12/13 suppresses diverse paths to KRASG12C inhibitor resistance in NSCLC (Haura) S100A9 as a novel immunotherapeutic target in Chronic Lymphocytic Leukemia (Pinilla-Ibarz) Development and early clinical testing of IFNβ and membrane-stable CD40L expressing oncolytic virus to maximize systemic T cell immunity through dendritic cell activation and lymph node trafficking (Beg) Validation of Low Limit of Detection for Myeloid Action 98 Gene Panel (MAP98) for Residual Disease Monitoring (Bossler)

193

141

167

099

178 176 116

142

MOFFITT SCIENTIFIC SYMPOSIUM COMMITTEE Dr. Jong Park (Co-Chair) Dr. Evan Wuthrick (Co-Chair) Dr Yoga Balagurunathan Dr. Leidy Isenalumhe Dr. Zena Jameel Dr. Estefania Julia Dr. John Mullinax Dr. Russell Palm Dr. Gage Redler Dr. Katarzyna Rejniak Dr. Maria Sandoval Dr. Michael Shafique Dr. Vani Simmons Dr. Lixin Wan Dr. Liang Wang

EVENT COORDINATORS Angela Reagan Kassie Morehouse